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Relevant bibliographies by topics / Thalamic neuron

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Academic literature on the topic 'Thalamic neuron'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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Journal articles on the topic "Thalamic neuron"

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Alloway, K. D., M. B. Wallace, and M. J. Johnson. "Cross-correlation analysis of cuneothalamic interactions in the rat somatosensory system: influence of receptive field topography and comparisons with thalamocortical interactions." Journal of Neurophysiology 72, no. 4 (1994): 1949–72. http://dx.doi.org/10.1152/jn.1994.72.4.1949.

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1. We simultaneously recorded neuronal responses to cutaneous stimulation from matched somatotopic representations in the nucleus cuneatus and ventrobasal complex of intact, halothane-anesthetized rats. A total of 95 cuneate and 86 thalamic neurons representing hairy skin on the forelimb were activated by hair movements produced by air jets at multiple skin sites. Mean responsiveness was higher among neurons in nucleus cuneatus (34.4 spikes per stimulus) than in thalamus (23.7 spikes per stimulus), a result that was consistent with the greater proportion of “sustained” responses recorded in nu

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Pesavento, Michael J., Cynthia D. Rittenhouse, and David J. Pinto. "Response Sensitivity of Barrel Neuron Subpopulations to Simulated Thalamic Input." Journal of Neurophysiology 103, no. 6 (2010): 3001–16. http://dx.doi.org/10.1152/jn.01053.2009.

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Our goal is to examine the relationship between neuron- and network-level processing in the context of a well-studied cortical function, the processing of thalamic input by whisker-barrel circuits in rodent neocortex. Here we focus on neuron-level processing and investigate the responses of excitatory and inhibitory barrel neurons to simulated thalamic inputs applied using the dynamic clamp method in brain slices. Simulated inputs are modeled after real thalamic inputs recorded in vivo in response to brief whisker deflections. Our results suggest that inhibitory neurons require more input to r

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Lytton, William W., Diego Contreras, Alain Destexhe, and Mircea Steriade. "Dynamic Interactions Determine Partial Thalamic Quiescence in a Computer Network Model of Spike-and-Wave Seizures." Journal of Neurophysiology 77, no. 4 (1997): 1679–96. http://dx.doi.org/10.1152/jn.1997.77.4.1679.

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Lytton, William W., Diego Contreras, Alain Destexhe, and Mircea Steriade. Dynamic interactions determine partial thalamic quiescence in a computer network model of spike-and-wave seizures. J. Neurophysiol. 77: 1679–1696, 1997. In vivo intracellular recording from cat thalamus and cortex was performed during spontaneous spike-wave seizures characterized by synchronously firing cortical neurons correlated with the electroencephalogram. During these seizures, thalamic reticular (RE) neurons discharged with long spike bursts riding on a depolarization, whereas thalamocortical (TC) neurons were eit

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Kasten, Michael R., and Matthew P. Anderson. "Self-regulation of adult thalamocortical neurons." Journal of Neurophysiology 114, no. 1 (2015): 323–31. http://dx.doi.org/10.1152/jn.00800.2014.

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The thalamus acts as a conduit for sensory and other information traveling to the cortex. In response to continuous sensory stimulation in vivo, the firing rate of thalamocortical neurons initially increases, but then within a minute firing rate decreases and T-type Ca2+ channel-dependent action potential burst firing emerges. While neuromodulatory systems could play a role in this inhibitory response, we instead report a novel and cell-autonomous inhibitory mechanism intrinsic to the thalamic relay neuron. Direct intracellular stimulation of thalamocortical neuron firing initially triggered a

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Khatri, Vivek, Randy M. Bruno, and Daniel J. Simons. "Stimulus-Specific and Stimulus-Nonspecific Firing Synchrony and Its Modulation by Sensory Adaptation in the Whisker-to-Barrel Pathway." Journal of Neurophysiology 101, no. 5 (2009): 2328–38. http://dx.doi.org/10.1152/jn.91151.2008.

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The stimulus-evoked response of a cortical neuron depends on both details of the afferent signal and the momentary state of the larger network in which it is embedded. Consequently, identical sensory stimuli evoke highly variable responses. Using simultaneous recordings of thalamic barreloid and/or cortical barrel neurons in the rat whisker-to-barrel pathway, we determined the extent to which the responses of pairs of cells covary on a trial-by-trial basis. In the thalamus and cortical layer IV, a substantial component of trial-to-trial variability is independent of the specific parameters of

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Kumbhare, Deepak, Md Ali Azam, Ravi Hadimani, et al. "Healthy and pathological pallidal regulation of thalamic burst versus tonic mode firing: a computational simulation." NeuroReport 34, no. 16 (2023): 773–80. http://dx.doi.org/10.1097/wnr.0000000000001955.

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The mechanisms by which the basal ganglia influence the pallidal-receiving thalamus remain to be adequately defined. Our prior in vivo recordings in fully alert normal and dystonic rats revealed that normally fast tonic discharging entopeduncular [EP, rodent equivalent of the globus pallidus internus (GPi)] neurons are pathologically slow, highly irregular, and bursty under dystonic conditions. This, in turn, induces pallidal-receiving thalamic movement-related neurons to change from a healthy burst predominant to a pathological tonic-predominant resting firing mode. This study aims to underst

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Azimirad, Vahid, and Mohammad Fattahi Sani. "Experimental Study of Reinforcement Learning in Mobile Robots Through Spiking Architecture of Thalamo-Cortico-Thalamic Circuitry of Mammalian Brain." Robotica 38, no. 9 (2019): 1558–75. http://dx.doi.org/10.1017/s0263574719001632.

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SUMMARYIn this paper, the behavioral learning of robots through spiking neural networks is studied in which the architecture of the network is based on the thalamo-cortico-thalamic circuitry of the mammalian brain. According to a variety of neurons, the Izhikevich model of single neuron is used for the representation of neuronal behaviors. One thousand and ninety spiking neurons are considered in the network. The spiking model of the proposed architecture is derived and prepared for the learning problem of robots. The reinforcement learning algorithm is based on spike-timing-dependent plastici

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Viaene, Angela N., Iraklis Petrof, and S. Murray Sherman. "Synaptic Properties of Thalamic Input to Layers 2/3 and 4 of Primary Somatosensory and Auditory Cortices." Journal of Neurophysiology 105, no. 1 (2011): 279–92. http://dx.doi.org/10.1152/jn.00747.2010.

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We studied the synaptic profile of thalamic inputs to cells in layers 2/3 and 4 of primary somatosensory (S1) and auditory (A1) cortices using thalamocortical slices from mice age postnatal days 10–18. Stimulation of the ventral posterior medial nucleus (VPM) or ventral division of the medial geniculate body (MGBv) resulted in two distinct classes of responses. The response of all layer 4 cells and a minority of layers 2/3 cells to thalamic stimulation was Class 1, including paired-pulse depression, all-or-none responses, and the absence of a metabotropic component. On the other hand, the majo

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Thomas, Elizabeth, and Thierry Grisar. "Increased Synchrony with Increase of a Low-Threshold Calcium Conductance in a Model Thalamic Network: A Phase-Shift Mechanism." Neural Computation 12, no. 7 (2000): 1553–71. http://dx.doi.org/10.1162/089976600300015268.

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A computer model of a thalamic network was used in order to examine the effects of an isolated augmentation in a low-threshold calcium current. Such an isolated augmentation has been observed in the reticular thalamic (RE) nucleus of the genetic absence epilepsy rat from the Strasbourg (GAERS) model of absence epilepsy. An augmentation of the low-threshold calcium conductance in the RE neurons (gTs) of the model thalamic network was found to lead to an increase in the synchronized firing of the network. This supports the hypothesis that the isolated increase in gTs may be responsible for epile

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Johnson, M. J., and K. D. Alloway. "Cross-correlation analysis reveals laminar differences in thalamocortical interactions in the somatosensory system." Journal of Neurophysiology 75, no. 4 (1996): 1444–57. http://dx.doi.org/10.1152/jn.1996.75.4.1444.

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1. Spontaneous and stimulus-induced activity were recorded from corresponding somatotopic representations in the ventroposterolateral nucleus (VPL) of the thalamus and primary somatosensory (SI) cortex of intact, halothane-anesthetized cats. Thalamic and cortical neurons with overlapping receptive fields on the hairy skin of the forelimb were excited by a series of interleaved air jets aimed at multiple skin sites. 2. The laminar locations of 68% (240 of 355) of the neurons recorded in SI cortex were histologically reconstructed and responses of these 240 SI neurons were analyzed with respect

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Dissertations / Theses on the topic "Thalamic neuron"

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Kuramoto, Eriko. "Two types of thalamocortical projections from the motor thalamic nuclei of the rat: a single neuron tracing study using viral vectors." Kyoto University, 2009. http://hdl.handle.net/2433/124305.

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Nakamura, Hisashi. "Different cortical projections from three subdivisions of the rat lateral posterior thalamic nucleus: a single neuron tracing study with viral vectors." Kyoto University, 2016. http://hdl.handle.net/2433/216156.

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Final publication is available at http://dx.doi.org/10.1111/ejn.12882<br>Kyoto University (京都大学)<br>0048<br>新制・論文博士<br>博士(医学)<br>乙第13040号<br>論医博第2115号<br>新制||医||1017(附属図書館)<br>33032<br>京都大学大学院医学研究科医学専攻<br>(主査)教授渡邉大, 教授影山龍一郎, 教授髙橋良輔<br>学位規則第4条第2項該当

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SERRA, LINDA. "Role of the Sox2 and COUP-TF1 transcription factors in the development of the visual system by conditional knock-out in mouse." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2020. http://hdl.handle.net/10281/261939.

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Il fattore di trascrizione Sox2 è espresso nel sistema nervoso dall’inizio del suo sviluppo dove è richiesto per il mantenimento delle cellule staminali. Nell'uomo, le mutazioni eterozigoti di Sox2 sono collegate a vari difetti del sistema nervoso centrale, inclusi i difetti visivi. Il sistema visivo è composto dall'occhio, dal nucleo talamico genicolato dorsolaterale (dLGN) e dalla corteccia visiva, che sono altamente interconnessi. L'occhio, infatti, invia le afferenze retiniche ad uno specifico nucleo talamico dorsale, il dLGN, i cui neuroni a loro volta proiettano verso l'area corticale vi

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Wu, Huiying. "Modeling thalamic activity and neural bursting." Thesis, The University of Sydney, 2009. https://hdl.handle.net/2123/28236.

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The human brain is the most complicated organ in the central nervous system. Although an enormous number of studies have been conducted to attempt to understand the brain and its activity, most of the functions of the brain and the mechanisms of its large scale activities are still not clear. In this thesis, a mean— field approach is used to study the thalamus, which is the sensory gateway of the brain and a key component of the thalamocortical system, and also neural bursting, which is an important type of neural activity. Chapter 1 provides an overview of the thesis, as well as brie

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Dacre, Joshua Rupert Heaton. "Thalamic control of motor behaviour." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29530.

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The primary motor cortex (M1) is a key brain area for the generation and control of motor behaviour. Output from M1 can be driven in part by long-range inputs from a collection of thalamic nuclei termed the motor thalamus (MTh), but how MTh input shapes activity in M1 and forelimb motor behaviour remains largely unresolved. To address this issue, we first defined the 3D anatomical coordinates of mouse forelimb motor thalamus (MThFL) by employing conventional retrograde and virus-based tracing methods targeted to the forelimb region of M1 (M1FL). These complimentary approaches defined MThFL as

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Lee, Stephanie G. "Medial lemniscal evoked responses in thalamic ethmoid neurons." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/31658.

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This thesis describes electrophysiological and pharmacological properties of neurons in the ethmoid nucleus of the rat thalamus. According to the atlas by Paxinos and Watson, the ethmoid nucleus is located dorsal to the medial lemniscus, the major somatosensory input to the thalamus. The ethmoid also lies ventral to the parafascicular nucleus, caudal to the ventrobasal thalamus and rostral to the scaphoid nucleus. The ethmoid is considered a higher order nucleus, which implies that it serves as a link in corticothalamo- cortical pathways that process sensory information. The literature o

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Pudenz, Christiane [Verfasser]. "Thalamo-cortical circuits for the processing of tactile information : thalamic inputs onto excitatory neurons in layer IV of the mouse barrel cortex." Freiburg : Universität, 2010. http://d-nb.info/1115490478/34.

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Shiraishi, Atsushi. "Generation of thalamic neurons from mouse embryonic stem cells." Kyoto University, 2018. http://hdl.handle.net/2433/230993.

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Meuth, Patrick [Verfasser], and Martin [Akademischer Betreuer] Burger. "Thalamic neurons in silico / Patrick Meuth. Betreuer: Martin Burger." Münster : Universitäts- und Landesbibliothek der Westfälischen Wilhelms-Universität, 2011. http://d-nb.info/1027017827/34.

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Ruffo, Mark. "The role of the corticothalamic projection in the primate motor thalamus /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/10626.

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Books on the topic "Thalamic neuron"

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Steriade, Mircea. Thalamic oscillations and signaling. Wiley, 1990.

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Diego, Minciacchi, ed. Thalamic networks for relay and modulation. Pergamon Press, 1993.

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MacMillan, Meeka. Responses of human thalamic and subthalamic nucleus neurons during sequential movements. National Library of Canada, 2002.

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Patra, Sanjay. Response properties of human thalamic neurons to high frequency micro-stimulation. National Library of Canada, 2001.

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Zoltán, Molnár. Development of thalamocortical connections. Springer, 1998.

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Takao, Kumazawa, Kruger Lawrence, and Mizumura Kazue, eds. The polymodal receptor: A gateway to pathological pain. Elsevier, 1996.

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Saalmann, Yuri B., and Sabine Kastner. Neural Mechanisms of Spatial Attention in the Visual Thalamus. Edited by Anna C. (Kia) Nobre and Sabine Kastner. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199675111.013.013.

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Neural mechanisms of selective attention route behaviourally relevant information through brain networks for detailed processing. These attention mechanisms are classically viewed as being solely implemented in the cortex, relegating the thalamus to a passive relay of sensory information. However, this passive view of the thalamus is being revised in light of recent studies supporting an important role for the thalamus in selective attention. Evidence suggests that the first-order thalamic nucleus, the lateral geniculate nucleus, regulates the visual information transmitted from the retina to

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Montgomery, Erwin B. Discrete Neural Oscillators. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190259600.003.0017.

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The therapeutic mechanisms of action of DBS likely involve neural and neuronal oscillators. “Neuronal oscillators” describes periodic fluctuations of electrical potentials across the neuronal membrane, particularly in the soma, which is reflected in an action-potential-initiating segment. “Neural oscillators” describes closed loop (feedback) multi-neuronal polysynaptic circuits, on account of the propagations of action potentials through the circuit. Neural oscillators are the focus of this chapter. The features, properties and dyanmics introduced in Chapter 16 – Basic Oscillators are extended

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Bleck, Thomas P. Pathophysiology and causes of seizures. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0231.

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Seizures result from imbalances between excitation and inhibition, and between neuronal synchrony and dyssynchrony. Current models implicate the cerebral cortex in the genesis of seizures, although thalamic mechanisms (particularly the thalamic reticular formation) are involved in the synchronization of cortical neurons. Often, the precipitants of a seizure in the critical care setting are pharmacological. Several mechanisms linked to critical illness can lead to seizures. Failure to remove glutamate and potassium from the extracellular space, functions performed predominantly by astrocytes, o

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Halassa, Michael M., ed. The Thalamus. Cambridge University Press, 2022. http://dx.doi.org/10.1017/9781108674287.

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The thalamus is a key structure in the mammalian brain, providing a hub for communication within and across distributed forebrain networks. Research in this area has undergone a revolution in the last decade, with findings that suggest an expanded role for the thalamus in sensory processing, motor control, arousal regulation, and cognition. Moving beyond previous studies of anatomy and cell neurochemistry, scientists have expanded into investigations of cognitive function, and harness new methods and theories of neural computation. This book provides a survey of topics at the cutting edge of t

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Book chapters on the topic "Thalamic neuron"

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Davis, Karen D., and Jonathan O. Dostrovsky. "Human Thalamic Nociceptive Neurons." In Encyclopedia of Pain. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-28753-4_1791.

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Angel, Anthony. "Thalamus." In Neural Mechanisms of Anesthesia. Humana Press, 2003. https://doi.org/10.1007/978-1-59259-322-4_8.

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Harrison, David W. "Thalamic and Hypothalamic Syndromes." In Brain Asymmetry and Neural Systems. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-13069-9_10.

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Destexhe, A., and A. Babloyantz. "Cortical Coherent Activity Induced by Thalamic Oscillations." In Neural Network Dynamics. Springer London, 1992. http://dx.doi.org/10.1007/978-1-4471-2001-8_17.

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Cisternas, Jaime E., Thomas M. Wasylenko, and Ioannis G. Kevrekidis. "Lurching waves in thalamic neuronal networks." In Localized States in Physics: Solitons and Patterns. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-16549-8_13.

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Guo, Daqing, Mingming Chen, Yang Xia, and Dezhong Yao. "Self-connection of Thalamic Reticular Nucleus Modulating Absence Seizures." In Neural Information Processing. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-70093-9_65.

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Kataoka, Kazuo, Kazuo Yamada, Tatsuya Tokuno, et al. "Neurofunctional Changes in Thalamic Neurons After Cortical Ablation in Adult Rats: Effect of Basic Fibroblast Growth Factor upon Thalamic Neurons." In Recent Advances in Neurotraumatology. Springer Japan, 1993. http://dx.doi.org/10.1007/978-4-431-68231-8_51.

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Wang, Xiao-Jing, John Rinzel, and Michael A. Rogawski. "Low Threshold Spikes and Rhythmic Oscillations in Thalamic Neurons." In Analysis and Modeling of Neural Systems. Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-4010-6_8.

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Miller, Michael W., and Richard T. Robertson. "Development of Cingulate Cortex: Proteins, Neurons, and afferents." In Neurobiology of Cingulate Cortex and Limbic Thalamus. Birkhäuser Boston, 1993. http://dx.doi.org/10.1007/978-1-4899-6704-6_5.

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Ohye, Chihiro, Sumito Sato, and Tohru Shibazaki. "Activity of Thalamic Ventralis Oralis Neurons in Rigid-Type Parkinson’s Disease." In Advances in Behavioral Biology. Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-0340-2_43.

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Conference papers on the topic "Thalamic neuron"

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Chauhan, Vibha, Quy Nguyen, Jeremy Francis, and Paola Leone. "Differential Degeneration of Neurons in a Mouse Model of Canavan Disease." In 27th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2023. https://doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.68_2023.

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Canavan disease (CD) is an inherited leukodystrophy caused by inactivating mutations to the glial enzyme aspartoacylase (ASPA). ASPA catabolizes neuronal N-acetylaspartate (NAA) into free acetate and aspartate and loss of this function results in the chronic elevation of non-catabolized NAA and the failure of developmental myelination. Elevated NAA is thought to cause damage to myelin and myelin-producing cells (oligodendrocytes, but the viability of neurons in CD is relatively unexplored. We compare here the progressive degeneration of neurons in two regions of the CD mouse brain, the thalamu

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Su, Fei, Min Chen, Hong Wang, and Linlu Zu. "FPGA Implementation of the Single Thalamic Neuron Model." In 2019 12th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics (CISP-BMEI). IEEE, 2019. http://dx.doi.org/10.1109/cisp-bmei48845.2019.8965996.

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Yin, Huibing, Charles L. Cox, Prashant G. Mehta, and Uday V. Shanbhag. "Bifurcation analysis of a thalamic relay neuron model." In 2009 American Control Conference. IEEE, 2009. http://dx.doi.org/10.1109/acc.2009.5160443.

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Kazemi, Amirhosein, Arash Ahmadi, and Shaghayegh Gomar. "A digital synthesis of hindmarsh-rose neuron: A thalamic neuron model of the brain." In 2014 22nd Iranian Conference on Electrical Engineering (ICEE). IEEE, 2014. http://dx.doi.org/10.1109/iraniancee.2014.6999539.

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Panetsos, Fivos, Elena Diaz-de Cerio, Abel Sanchez-Jimenez, and Celia Herrera-Rincon. "Thalamic visual neuroprostheses: Comparison of visual percepts generated by natural stimulation of the eye and electrical stimulation of the thalamus." In 2009 4th International IEEE/EMBS Conference on Neural Engineering (NER). IEEE, 2009. http://dx.doi.org/10.1109/ner.2009.5109233.

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Jandel, Magnus. "Thalamic bursts mediate pattern recognition." In 2009 4th International IEEE/EMBS Conference on Neural Engineering (NER). IEEE, 2009. http://dx.doi.org/10.1109/ner.2009.5109358.

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Krebs, Hermano I., Neville Hogan, Bruce Volpe, Mindy Aisen, Lisa Edelstein, and Christa Diels. "Robot-Aided Neuro-Rehabilitation in Stroke: Neuro-Recovery for Thalamic Lesion." In ASME 1999 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/imece1999-0081.

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Abstract We are applying robotics and information technology to assist, enhance, and quantify neuro-rehabilitation. Our goal is a new class of interactive, user-affectionate clinical devices designed not only for evaluating patients, but also for delivering meaningful therapy via engaging “video games.” Notably, the novel robot MIT-MANUS has been designed and programmed for clinical neurological applications, and has undergone extensive clinical trials for more than four years at Burke Rehabilitation Hospital – White Plains, NY. This paper will review the main result of the pilot clinical tria

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Faria, Danilo Donizete de, Joselisa Péres Queiroz de Paiva, Artur Jose Marques Paulo, et al. "Structural MRI analysis of basal ganglia volume and white matter tracts in upper limb dystonia." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.547.

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Background: Dystonia is known as a network disorder. There is evidence of volumetric changes in structures associated with the traditional physiopathology, such as basal nuclei. One approach to studying the neural pathways is through tractography, which can provide insights into the structural connectivity of neural networks that may be disrupted in dystonia. Objectives: To evaluate brain structural changes of motor networks and basal ganglia volume in dystonia. Methods: Twenty-six patients with right upper limb dystonia and 29 healthy controls underwent 3T magnetic resonance imaging and evalu

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Rufino, Adonai Alencar, Beatriz Girão Portela, Alan Alves de Lima Cidrão, Deborah Moreira Rangel, and Vitor Araújo Marinho. "Unraveling the mysteries of the midbrain – A case report." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.623.

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Context: The rostral midbrain and thalamomesencephalic junction are the supranuclear premotor control of vertical eye movements, and is supplied by the posterior thalamo-subthalamic paramedian artery originated from P1 segment of posterior cerebral artery. Case report: A 51-year-old man presented with sudden speech difficulties, dizziness and dyplopia, associated with moderate intensity headache. Neuroophthalmological examination revealed incomplete ptosis of the right eye, with mydriatic pupil, poorly reactive to light. No eye movements were present on attempted upward gaze. On attempted down

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Millard, Daniel C., Qi Wang, and Garrett B. Stanley. "Nonlinear system identification of the thalamocortical circuit in response to thalamic microstimulation." In 5th International IEEE/EMBS Conference on Neural Engineering (NER 2011). IEEE, 2011. http://dx.doi.org/10.1109/ner.2011.5910475.

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Reports on the topic "Thalamic neuron"

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Morrow, Thomas J. Modulation of Thalamic Somatosensory Neurons by Arousal and Attention. Defense Technical Information Center, 1988. http://dx.doi.org/10.21236/ada200073.

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Zhang, Yu, Chaoliang Sun, Hengxi Xu, et al. Connectivity-Based Subtyping of De Novo Parkinson Disease: Biomarkers, Medication Effects and Longitudinal Progression. Progress in Neurobiology, 2024. http://dx.doi.org/10.60124/j.pneuro.2024.10.04.

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Abstract:

Parkinson's disease (PD) is characterized by divergent clinical symptoms and prognosis, suggesting the presence of distinct subtypes. Identifying these subtypes is crucial for understanding the underlying pathophysiology, predicting disease progression, and developing personalized treatments. In this study, we propose a connectivity-based subtyping approach, which measures each patient's deviation from the reference structural covariance networks established in healthy controls. Using data from the Parkinson's Progression Markers Initiative, we identified two distinct subtypes of de novo PD pa

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