Journal articles on the topic 'TGFβ1 treatment'
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Budhu, Sadna, Aditi Gupta, Kelly Fitzgerald, Rachel Giese, Adam Michel, Aliya Holland, Luis Felipe Campesato, et al. "567 Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of stroma poor cancers." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (November 2021): A596. http://dx.doi.org/10.1136/jitc-2021-sitc2021.567.
Full textBudhu, Sadna, Aditi Gupta, Rachel Giese, Jacques van Snick, Catherine Uyttenhove, Gerd Ritter, Jedd D. Wolchok, and Taha Merghoub. "Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer." Journal of Immunology 202, no. 1_Supplement (May 1, 2019): 136.23. http://dx.doi.org/10.4049/jimmunol.202.supp.136.23.
Full textShynlova, Oksana, Prudence Tsui, Anna Dorogin, B. Lowell Langille, and Stephen J. Lye. "The expression of transforming growth factor β in pregnant rat myometrium is hormone and stretch dependent." Reproduction 134, no. 3 (September 2007): 503–11. http://dx.doi.org/10.1530/rep-07-0004.
Full textQuintela, M., R. M. SeñarÍs, and C. Diéguez. "Transforming Growth Factor-βs Inhibit Somatostatin Messenger Ribonucleic Acid Levels and Somatostatin Secretion in Hypothalamic Cells in Culture*." Endocrinology 138, no. 10 (October 1, 1997): 4401–9. http://dx.doi.org/10.1210/endo.138.10.5467.
Full textVarricchio, Lilian, John Mascarenhas, Anna Rita Migliaccio, Maureen O'Connor-McCourt, Gilles Tremblay, Jean-François Denis, Camelia Iancu-Rubin, and Ronald Hoffman. "AVID200, a Potent Trap for TGF-β Ligands Inhibits TGF-β1 Signaling in Human Myelofibrosis." Blood 132, Supplement 1 (November 29, 2018): 1791. http://dx.doi.org/10.1182/blood-2018-99-116474.
Full textElsafadi, Mona, Muthurangan Manikandan, Sami Almalki, Mohammad Mobarak, Muhammad Atteya, Zafar Iqbal, Jamil Amjad Hashmi, et al. "TGFβ1-Induced Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the Actin Cytoskeleton." Stem Cells International 2018 (2018): 1–14. http://dx.doi.org/10.1155/2018/6913594.
Full textFeger, Martina, Ioana Alesutan, Tatsiana Castor, Sobuj Mia, Katharina Musculus, Jakob Voelkl, and Florian Lang. "Inhibitory Effect of NH4Cl Treatment on Renal Tgfß1 Signaling Following Unilateral Ureteral Obstruction." Cellular Physiology and Biochemistry 37, no. 3 (2015): 955–64. http://dx.doi.org/10.1159/000430222.
Full textRecouvreux, M. Victoria, M. Andrea Camilletti, Daniel B. Rifkin, and Graciela Díaz-Torga. "The pituitary TGFβ1 system as a novel target for the treatment of resistant prolactinomas." Journal of Endocrinology 228, no. 3 (December 23, 2015): R73—R83. http://dx.doi.org/10.1530/joe-15-0451.
Full textMartin, Constance J., Abhishek Datta, Christopher Littlefield, Ashish Kalra, Christopher Chapron, Stefan Wawersik, Kevin B. Dagbay, et al. "Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape." Science Translational Medicine 12, no. 536 (March 25, 2020): eaay8456. http://dx.doi.org/10.1126/scitranslmed.aay8456.
Full textPeng, Fangfang, Baifang Zhang, Dongcheng Wu, Alistair J. Ingram, Bo Gao, and Joan C. Krepinsky. "TGFβ-induced RhoA activation and fibronectin production in mesangial cells require caveolae." American Journal of Physiology-Renal Physiology 295, no. 1 (July 2008): F153—F164. http://dx.doi.org/10.1152/ajprenal.00419.2007.
Full textUeland, Thor, Tove Lekva, Kari Otterdal, Tuva B. Dahl, Nicoleta Cristina Olarescu, Anders P. Jørgensen, Kristian J. Fougner, Kim Brixen, Pål Aukrust, and J. Bollerslev. "Increased serum and bone matrix levels of transforming growth factor β1 in patients with GH deficiency in response to GH treatment." European Journal of Endocrinology 165, no. 3 (September 2011): 393–400. http://dx.doi.org/10.1530/eje-11-0442.
Full textStasyk, Taras, Anna Dubrovska, Marta Lomnytska, Ihor Yakymovych, Christer Wernstedt, Carl-Henrik Heldin, Ulf Hellman, and Serhiy Souchelnytskyi. "Phosphoproteome Profiling of Transforming Growth Factor (TGF)-β Signaling: Abrogation of TGFβ1-dependent Phosphorylation of Transcription Factor-II-I (TFII-I) Enhances Cooperation of TFII-I and Smad3 in Transcription." Molecular Biology of the Cell 16, no. 10 (October 2005): 4765–80. http://dx.doi.org/10.1091/mbc.e05-03-0257.
Full textJacko, AM, L. Nan, J. Wei, J. Zhao, and Y. Zhao. "ID: 107: MITOXANTRONE INHIBITS TGFβ1-INDUCED SIGNALING THROUGH PROMOTING TGFβ RECEPTOR II DEGRADATION." Journal of Investigative Medicine 64, no. 4 (March 22, 2016): 962.1–962. http://dx.doi.org/10.1136/jim-2016-000120.104.
Full textGah, Asma, Mir S. Adil, Harika Sabbineni, Arti Verma, and Payaningal R. Somanath. "Differential regulation of TGFβ type-I receptor expressions in TGFβ1-induced myofibroblast differentiation." Canadian Journal of Physiology and Pharmacology 98, no. 12 (December 2020): 841–48. http://dx.doi.org/10.1139/cjpp-2020-0123.
Full textSuragani, Rajasekhar NVS, Pedro A. Martinez, Sharon M. Cawley, Robert Li, Robert Scott Pearsall, and Ravindra Kumar. "TGFb1 Antagonist Inhibits Fibrosis in a Murine Model of Myelofibrosis." Blood 126, no. 23 (December 3, 2015): 605. http://dx.doi.org/10.1182/blood.v126.23.605.605.
Full textZhang, Lei, Eiji Sato, Kenichi Amagasaki, Atsuhito Nakao, and Hirofumi Naganuma. "Participation of an abnormality in the transforming growth factor–β signaling pathway in resistance of malignant glioma cells to growth inhibition induced by that factor." Journal of Neurosurgery 105, no. 1 (July 2006): 119–28. http://dx.doi.org/10.3171/jns.2006.105.1.119.
Full textZhou, Xin, Junhong Li, Ludvig J. Backman, and Patrik Danielson. "Keratocyte Differentiation Is Regulated by NF-κB and TGFβ Signaling Crosstalk." International Journal of Molecular Sciences 23, no. 19 (September 21, 2022): 11073. http://dx.doi.org/10.3390/ijms231911073.
Full textGuo, Hao, Lien Lu, Rijian Wang, Hayat Abdulkerim, Keith Reimann, Angus Thomson, and Mohamed Ezzelarab. "Impact of human mutant TGF-β1/Fc protein on memory and regulatory CD4+T cells following lymphodepletion in rhesus monkeys (THER2P.953)." Journal of Immunology 194, no. 1_Supplement (May 1, 2015): 67.4. http://dx.doi.org/10.4049/jimmunol.194.supp.67.4.
Full textMaharjan, Babu Raja, Susan V. McLennan, Stephen M. Twigg, and Paul F. Williams. "The Effect of TGFβ1 in Adipocyte on Inflammatory and Fibrotic Markers at Different Stages of Adipocyte Differentiation." Pathophysiology 29, no. 4 (November 23, 2022): 640–49. http://dx.doi.org/10.3390/pathophysiology29040050.
Full textIqbal, Aqsa, Ulrike May, Stuart N. Prince, Tero A. H. Järvinen, and Ahlke Heydemann. "Systemically Administered Homing Peptide Targets Dystrophic Lesions and Delivers Transforming Growth Factor-β (TGFβ) Inhibitor to Attenuate Murine Muscular Dystrophy Pathology." Pharmaceutics 13, no. 9 (September 18, 2021): 1506. http://dx.doi.org/10.3390/pharmaceutics13091506.
Full textDi Bartolo, Daniel, and Ethel Cesarman. "Inhibition of the TGFβ Pathway in Primary Effusion Lymphoma." Blood 108, no. 11 (November 16, 2006): 4352. http://dx.doi.org/10.1182/blood.v108.11.4352.4352.
Full textMengyao, Liu. "The Role of Matrix Metalloproteinase-13 (MMP13) in TGFβ/BMP Pathway Regulation of Fibro-Adipogenic Progenitor (FAP) Differentiation." Cellular Physiology and Biochemistry 56, no. 6 (December 20, 2022): 730–43. http://dx.doi.org/10.33594/000000596.
Full textYuan, Shuanghu, Jinming Yu, Xuwei Cai, and Feng-Ming (Spring) Kong. "The association of plasma TGFβ1 during radiotherapy and genotypes of TGFβ1 pathway in patients with non-small cell lung cancer." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): e21115-e21115. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e21115.
Full textLee, Mi-Sook, Tae Young Kim, Yong-Bae Kim, Sung-Yul Lee, Seong-Gyu Ko, Hyun-Soon Jong, Tae-You Kim, Yung-Jue Bang, and Jung Weon Lee. "The Signaling Network of Transforming Growth Factor β1, Protein Kinase Cδ, and Integrin Underlies the Spreading and Invasiveness of Gastric Carcinoma Cells." Molecular and Cellular Biology 25, no. 16 (August 15, 2005): 6921–36. http://dx.doi.org/10.1128/mcb.25.16.6921-6936.2005.
Full textPetiti, Juan Pablo, Liliana del Valle Sosa, María Eugenia Sabatino, Alicia Maldré Vaca, Silvina Gutiérrez, Ana Lucía De Paul, and Alicia Inés Torres. "Involvement of MEK/ERK1/2 and PI3K/Akt Pathways in the Refractory Behavior of GH3B6 Pituitary Tumor Cells to the Inhibitory Effect of TGFβ1." Endocrinology 156, no. 2 (November 13, 2014): 534–47. http://dx.doi.org/10.1210/en.2014-1070.
Full textHong, Liu, Yasuhiko Tabata, Susumu Miyamoto, Masaya Yamamoto, Keisuke Yamada, Nobuo Hashimoto, and Yoshito Ikada. "Bone regeneration at rabbit skull defects treated with transforming growth factor—β1 incorporated into hydrogels with different levels of biodegradability." Journal of Neurosurgery 92, no. 2 (February 2000): 315–25. http://dx.doi.org/10.3171/jns.2000.92.2.0315.
Full textWei, J., AM Jacko, L. Nan, J. Zhao, J. Tan, DJ Kass, and Y. Zhao. "ID: 108: DEUBIQUITINATING ENZYME 11 STABILIZES TGFβ RECEPTOR II AND REGULATES TGFβ1 SIGNALING IN PULMONARY FIBROBLAST." Journal of Investigative Medicine 64, no. 4 (March 22, 2016): 962.2–963. http://dx.doi.org/10.1136/jim-2016-000120.105.
Full textNam, Bora, Hyosun Park, Young Lim Lee, Younseo Oh, Jinsung Park, So Yeon Kim, Subin Weon, et al. "TGFβ1 Suppressed Matrix Mineralization of Osteoblasts Differentiation by Regulating SMURF1–C/EBPβ–DKK1 Axis." International Journal of Molecular Sciences 21, no. 24 (December 21, 2020): 9771. http://dx.doi.org/10.3390/ijms21249771.
Full textT.A., Dronova,, Babyshkina, N.N., Slonimskaya, E.M., and Cherdyntseva, N.V. "FEATURES OF EXPRESSION OF TRANSFORMING GROWTH FACTOR BETA IN ESTROGEN-POSITIVE BREAST CANCER." CARDIOMETRY, no. 24 (November 30, 2022): 62. http://dx.doi.org/10.18137/cardiometry.2022.24.conf.33.
Full textDanforth, D. N. "All trans-retinoic acid acts synergistically with hydroxytamoxifen and transforming-growth factor β to stimulate apoptosis in MCF-7 breast cancer cells." Journal of Endocrinology 183, no. 2 (November 2004): 395–404. http://dx.doi.org/10.1677/joe.1.05497.
Full textMascarenhas, John, Heidi E. Kosiorek, Lilian Varricchio, Rupali Bhave, Andrew T. Kuykendall, Rami Komrokji, Aaron T. Gerds, et al. "Rationale for and Results of a Phase I Study of the TGF-β 1/3 Inhibitor AVID200 in Subjects with Myelofibrosis: MPN-RC 118 Trial." Blood 136, Supplement 1 (November 5, 2020): 6–8. http://dx.doi.org/10.1182/blood-2020-140830.
Full textPhanish, Mysore K., Nadia A. Wahab, Paul Colville-Nash, Bruce M. Hendry, and Mark E. C. Dockrell. "The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFβ1 responses in human proximal-tubule epithelial cells." Biochemical Journal 393, no. 2 (December 23, 2005): 601–7. http://dx.doi.org/10.1042/bj20051106.
Full textYap, Timothy A., Minal A. Barve, Justin F. Gainor, Colin D. Weekes, Bruno Bockorny, Yawen Ju, Ryan Faucette, et al. "First-in-human phase 1 trial (DRAGON) of SRK-181, a potential first-in-class selective latent TGFβ1 inhibitor, alone or in combination with anti-PD-(L)1 treatment in patients with advanced solid tumors." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): TPS3146. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.tps3146.
Full textDe, A., T. E. Morgan, R. C. Speth, N. Boyadjieva, and D. K. Sarkar. "Pituitary lactotrope expresses transforming growth factor β (TGFβ) type II receptor mRNA and protein and contains 125I-TGFβ1 binding sites." Journal of Endocrinology 149, no. 1 (April 1996): 19–27. http://dx.doi.org/10.1677/joe.0.1490019.
Full textBendinelli, Paola, Paola Maroni, Valentina Dall’Olio, Emanuela Matteucci, and Maria Alfonsina Desiderio. "Bone Metastasis Phenotype and Growth Undergo Regulation by Micro-Environment Stimuli: Efficacy of Early Therapy with HGF or TGFβ1-Type I Receptor Blockade." International Journal of Molecular Sciences 20, no. 10 (May 22, 2019): 2520. http://dx.doi.org/10.3390/ijms20102520.
Full textGronau, Tobias, Karsten Krüger, Carina Prein, Attila Aszodi, Isabel Gronau, Renato V. Iozzo, Frank C. Mooren, et al. "Forced exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin." Annals of the Rheumatic Diseases 76, no. 2 (July 4, 2016): 442–49. http://dx.doi.org/10.1136/annrheumdis-2016-209319.
Full textKramer, Elizabeth L., William D. Hardie, Satish K. Madala, Cynthia Davidson, and John P. Clancy. "Subacute TGFβ expression drives inflammation, goblet cell hyperplasia, and pulmonary function abnormalities in mice with effects dependent on CFTR function." American Journal of Physiology-Lung Cellular and Molecular Physiology 315, no. 3 (September 1, 2018): L456—L465. http://dx.doi.org/10.1152/ajplung.00530.2017.
Full textArrighi, Nicole, Claudine Moratal, Grégoire Savary, Julien Fassy, Nicolas Nottet, Nicolas Pons, Noémie Clément, et al. "The FibromiR miR-214-3p Is Upregulated in Duchenne Muscular Dystrophy and Promotes Differentiation of Human Fibro-Adipogenic Muscle Progenitors." Cells 10, no. 7 (July 20, 2021): 1832. http://dx.doi.org/10.3390/cells10071832.
Full textMohammed, Javed, Andrew Gunderson, Richard Koubek, and Adam Glick. "TGFβ1 promotes adaptive immune response by modulating skin dendritic cell function and migration (147.24)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 147.24. http://dx.doi.org/10.4049/jimmunol.186.supp.147.24.
Full textChen, Yun-Ju, Pei-Wen Hsiao, Ming-Ting Lee, J. Ian Mason, Ferng-Chun Ke, and Jiuan-Jiuan Hwang. "Interplay of PI3K and cAMP/PKA signaling, and rapamycin-hypersensitivity in TGFβ1 enhancement of FSH-stimulated steroidogenesis in rat ovarian granulosa cells." Journal of Endocrinology 192, no. 2 (February 2007): 405–19. http://dx.doi.org/10.1677/joe-06-0076.
Full textAlmilaji, Ahmad, Jing Yan, Zohreh Hosseinzadeh, Evi Schmid, Meinrad Gawaz, and Florian Lang. "Up-Regulation of Na+/Ca2+ Exchange in Megakaryocytes Following TGFβ1 Treatment." Cellular Physiology and Biochemistry 39, no. 2 (2016): 693–99. http://dx.doi.org/10.1159/000445660.
Full textSamon, Jeremy B., Ameya Champhekar, Lisa M. Minter, Janice C. Telfer, Lucio Miele, Abdul Fauq, Pritam Das, Todd E. Golde, and Barbara A. Osborne. "Notch1 and TGFβ1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells." Blood 112, no. 5 (September 1, 2008): 1813–21. http://dx.doi.org/10.1182/blood-2008-03-144980.
Full textFarina, G., R. Lemaire, P. Pancari, J. Bayle, R. L. Widom, and R. Lafyatis. "Cartilage oligomeric matrix protein expression in systemic sclerosis reveals heterogeneity of dermal fibroblast responses to transforming growth factor β." Annals of the Rheumatic Diseases 68, no. 3 (April 13, 2008): 435–41. http://dx.doi.org/10.1136/ard.2007.086850.
Full textÜnlü, A., and R. E. Leake. "Transforming Growth Factor β1 Stimulates Urokinase Plasminogen Activator System on Prostate Cancer Cells." International Journal of Biological Markers 18, no. 2 (April 2003): 147–51. http://dx.doi.org/10.1177/172460080301800208.
Full textJoshi, Pratibha, Aida Venado, Tiana Curry-McCoy, and David Guidot. "Activation of membrane TGFβ1 on alveolar macrophages by co-cultured alcohol primed alveolar epithelial cells (111.1)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 111.1. http://dx.doi.org/10.4049/jimmunol.186.supp.111.1.
Full textFernando, Josephine, and John Ryan. "TGF-β1 suppresses mast cell functions in vivo. (151.15)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 151.15. http://dx.doi.org/10.4049/jimmunol.186.supp.151.15.
Full textSharkey, D. J., R. B. Gilchrist, and S. A. Robertson. "176. GDF-9, BMP-15 AND ACTIVIN A CONTRIBUTE TO SEMINAL FLUID SIGNALLING IN HUMAN CERVICAL EPITHELIAL CELLS." Reproduction, Fertility and Development 21, no. 9 (2009): 94. http://dx.doi.org/10.1071/srb09abs176.
Full textSharma, Shweta, Rishov Goswami, Michael Merth, Jonathan Cohen, Kai Y. Lei, David X. Zhang, and Shaik O. Rahaman. "TRPV4 ion channel is a novel regulator of dermal myofibroblast differentiation." American Journal of Physiology-Cell Physiology 312, no. 5 (May 1, 2017): C562—C572. http://dx.doi.org/10.1152/ajpcell.00187.2016.
Full textWelsh, Brian T., Ryan Faucette, Sanela Bilic, Constance J. Martin, Thomas Schürpf, David Chen, Samantha Nicholls, Janice Lansita, and Ashish Kalra. "Nonclinical Development of SRK-181: An Anti-Latent TGFβ1 Monoclonal Antibody for the Treatment of Locally Advanced or Metastatic Solid Tumors." International Journal of Toxicology 40, no. 3 (March 19, 2021): 226–41. http://dx.doi.org/10.1177/1091581821998945.
Full textCollins, A. T., E. J. Robinson, and D. E. Neal. "Benign prostatic stromal cells are regulated by basic fibroblast growth factor and transforming growth factor-β1." Journal of Endocrinology 151, no. 2 (November 1996): 315–22. http://dx.doi.org/10.1677/joe.0.1510315.
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