Relevant bibliographies by topics / Tetramic Acid

Academic literature on the topic 'Tetramic Acid'

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Published: 4 June 2021
Last updated: 20 February 2023

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Journal articles on the topic "Tetramic Acid"

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Jiang, Minghua, Senhua Chen, Jing Li, and Lan Liu. "The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms." Marine Drugs 18, no. 2 (February 15, 2020): 114. http://dx.doi.org/10.3390/md18020114.

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Tetramic acid (pyrrolidine-2,4-dione) compounds, isolated from a variety of marine and terrestrial organisms, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities. In the past decade, marine-derived microorganisms have become great repositories of novel tetramic acids. Here, we discuss the biological activities of 277 tetramic acids of eight classifications (simple 3-acyl tetramic acids, 3-oligoenoyltetramic acids, 3-decalinoyltetramic acid, 3-spirotetramic acids, macrocyclic tetramic acids, N-acylated tetramic acids, α-cyclopiazonic acid-type tetramic acids, and other tetramic acids) from marine-derived microbes, including fungi, actinobacteria, bacteria, and cyanobacteria, as reported in 195 research studies up to 2019.
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Ueda, Chihiro, Kazuhiro Tateda, Manabu Horikawa, Soichiro Kimura, Yoshikazu Ishii, Kaoru Nomura, Kanako Yamada, et al. "Anti-Clostridium difficile Potential of Tetramic Acid Derivatives from Pseudomonas aeruginosa Quorum-Sensing Autoinducers." Antimicrobial Agents and Chemotherapy 54, no. 2 (November 16, 2009): 683–88. http://dx.doi.org/10.1128/aac.00702-09.

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ABSTRACT We have examined the potential bactericidal activities of several tetramic acids derived from Pseudomonas autoinducers against Clostridium difficile, a cause of antibiotic-associated pseudomembranous colitis. Clinical isolates of C. difficile (n = 4) were incubated in broth with a chemically synthesized Pseudomonas autoinducer and its tetramic acid derivatives. The structure-activity relationship and the mechanisms of action were examined by a time-killing assay and by determination of the morphological/staining characteristics. The use of some tetramic acids derived from N-3-oxododecanoyl l-homoserine lactone resulted in more than 3-log reductions in the viability of C. difficile within 30 min at 30 μM. The outer membrane was suggested to be one of the targets for the bactericidal activity of tetramic acid, because disturbance of the bacterial outer surface was demonstrated by alteration of the Gram-staining characteristic and electron microscopy. The data for the tetramic acid derivatives demonstrate that the keto-enol structure and the length of the acyl side chain of tetramic acid may be essential for the antibacterial activity of this molecule. These results suggest the potential for tetramic acid derivatives to be novel agents with activity against C. difficile.
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Stachel, Hans-Dietrich, and Josef Schachtner. "Synthese von Heteroanaloga der Penicillsäure / Synthesis of Hetero Analogues of Penicillic Acid." Zeitschrift für Naturforschung B 51, no. 9 (September 1, 1996): 1334–38. http://dx.doi.org/10.1515/znb-1996-0919.

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Neumann, Kerstin, Stefan Kehraus, Michael Gütschow, and Gabriele M. König. "Cytotoxic and HLE-Inhibitory Tetramic Acid Derivatives from Marine-Derived Fungi." Natural Product Communications 4, no. 3 (March 2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400308.

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Tetramic acid derivatives are an important class of nitrogen heterocycles with a pyrrolidine-2,4-dione core as a key structural motif. From the sponge-derived fungus Beauveria bassiana, a new equisetin-like tetramic acid derivative, beauversetin (1), was isolated. The sea weed-derived fungus Microdiplodia sp. produced the tetramic acid derivative 2 (Sch210972) which was shown to inhibit human leucocyte elastase (HLE) with an IC50 of 1.04 μg mL−1.
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Li, Yong, Zheng Huang, Jia Xu, Yong Ding, Dian-Yong Tang, Jie Lei, Hong-yu Li, Zhong-Zhu Chen, and Zhi-Gang Xu. "Microwave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction." Beilstein Journal of Organic Chemistry 16 (April 9, 2020): 663–69. http://dx.doi.org/10.3762/bjoc.16.63.

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A facile microwave-assisted method for the synthesis of tetramic acid derivatives has been developed through an Ugi/Dieckmann cyclization strategy with DBU. This two-step one-pot procedure afforded the targeted tetramic acid analogues in good yields. With commercially available Ugi starting materials, microwave irradiation, a simple operation, excellent yields, and a broad scope, this reaction has the potential to produce a large number of tetramic acid analogues, which cannot be easily accessed by the classic synthetic methods.
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Myrtle, J. D., A. M. Beekman, and R. A. Barrow. "Ravynic acid, an antibiotic polyeneyne tetramic acid from Penicillium sp. elucidated through synthesis." Organic & Biomolecular Chemistry 14, no. 35 (2016): 8253–60. http://dx.doi.org/10.1039/c6ob00938g.

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Unten, Yufu, Masatoshi Murai, Katsuyuki Sakai, Yukihiro Asami, Takenori Yamamoto, Takahiro Masuya, and Hideto Miyoshi. "Natural tetramic acids elicit multiple inhibitory actions against mitochondrial machineries presiding over oxidative phosphorylation." Bioscience, Biotechnology, and Biochemistry 85, no. 12 (October 8, 2021): 2368–77. http://dx.doi.org/10.1093/bbb/zbab176.

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ABSTRACT The mitochondrial machineries presiding over ATP synthesis via oxidative phosphorylation are promising druggable targets. Fusaramin, a 3-acyl tetramic acid isolated from Fusarium concentricum FKI-7550, is an inhibitor of oxidative phosphorylation in Saccharomyces cerevisiae mitochondria, although its target has yet to be identified. Fusaramin significantly interfered with [3H]ADP uptake by yeast mitochondria at the concentration range inhibiting oxidative phosphorylation. A photoreactive fusaramin derivative (pFS-5) specifically labeled voltage-dependent anion channel 1 (VDAC1), which facilitates trafficking of ADP/ATP across the outer mitochondrial membrane. These results strongly suggest that the inhibition of oxidative phosphorylation by fusaramin is predominantly attributable to the impairment of VDAC1 functions. Fusaramin also inhibited FoF1-ATP synthase and ubiquinol-cytochrome c oxidoreductase (complex III) at concentrations higher than those required for the VDAC inhibition. Considering that other tetramic acid derivatives are reported to inhibit FoF1-ATP synthase and complex III, natural tetramic acids were found to elicit multiple inhibitory actions against mitochondrial machineries.
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Poncet, Jo�l, Patrick Jouin, Bertrand Castro, Louisette Nicolas, Mohamed Boutar, and Alain Gaudemer. "Tetramic acid chemistry. Part 1. Reinvestigation of racemisation during the synthesis of tetramic acids via Dieckmann cyclisation." Journal of the Chemical Society, Perkin Transactions 1, no. 3 (1990): 611. http://dx.doi.org/10.1039/p19900000611.

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Marfori, Eufrocinio C., Shin' ichiro Kajiyama, Ei-ichiro Fukusaki, and Akio Kobayashi. "Phytotoxicity of the tetramic acid metabolite trichosetin." Phytochemistry 62, no. 5 (March 2003): 715–21. http://dx.doi.org/10.1016/s0031-9422(02)00629-5.

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Spatz, Julia H., Sebastian J. Welsch, David-Emmanuel Duhaut, Nadine Jäger, Thomas Boursier, Martin Fredrich, Lars Allmendinger, et al. "Tetramic acid derivatives via Ugi–Dieckmann-reaction." Tetrahedron Letters 50, no. 15 (April 2009): 1705–7. http://dx.doi.org/10.1016/j.tetlet.2009.01.124.

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Dissertations / Theses on the topic "Tetramic Acid"

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Bates, Andrew D. "New reactions in tetramic acid synthesis." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252629.

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Pillainayagam, Terence Anthony. "New methods in tetramic acid synthesis." Thesis, Loughborough University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416685.

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Lewis, Ian. "Studies in the synthesis of polyene tetramic acid antibiotics." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/12412.

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Moore, M. Caragh. "Biosynthetic studies on tenellin and aminoisobutyrate metabolism in Streptomyces sp." Thesis, Durham University, 1998. http://etheses.dur.ac.uk/4837/.

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This thesis is divided into two parts. Part 1 covers the biosynthesis of the fungal metabolite tenellin, and Part 2 the metabolism of β-aminoisobutyrate m Streptomyces sp. Tenellin is a yellow pigment of the fungus Beamaria bassiana. It is of mixed biosynthetic origin, being derived from a polyketide moiety and the amino acid L-phenylalanine. The timing of the C-methylations of the polyketide chain is discussed in Chapter 2, which describes attempts to incorporate deuterium labelled partially assembled putative intermediates into the polyketide. The biosynthesis of the pyridone ring of tenellin requkes the condensation of the polyketide moiety with a rearranged phenylpropanoid unit derived from phenylalanine. The nature of this intriguing intramolecular rearrangement is discussed in Chapters 3 and 4. A phenylalanine derived tetramic acid, proposed as an intermediate in the biosynthesis, has been synthesised, and used in biosynthetic investigations. The results of these investigations and the subsequent identification of tyrosine as a closer precursor to tenellin argue against its intermediacy. The failure of [2-(^13)C(^2)H(^15)N]-phenylalanine to become incorporated intact suggests a transamination process for phenylalanine / tyrosine prior to incorporation. Preliminary investigations suggest para-hydroxy phenyllactate may be die substrate for the rearranging enzyme and a more direct precursor to tenellin. β-Aminoisobutyrate, the end product of reductive thymine catabolism, contributes to both the propionate and butyrate pools in Streptomyces sp. The pathway of incorporation into the isobutyrate / butyrate pool has been investigated, and confirmed to be the reverse of that known to occur in L-valine metabolism. A mutant strain of Streptomyces avemitilis, unable to produce isobutyrate, was used due to low level incorporations into the branched-chain fatty acids. This work was carried out in collaboration with Dr. Hamish McArthur, Pfizer Central Research Division, Groton, USA, and Dr. Kevin Reynolds, Department of Pharmaceutical Science, University of Maryland.
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Fischer, Joshua. "HIV-1 Integrase Inhibitors: A Formal Total Synthesis of Lithospermic Acid And Synthetic Studies Towards Integramycin." Thesis, The University of Sydney, 2007. http://hdl.handle.net/2123/2397.

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This thesis describes synthetic studies towards the HIV-1 integrase inhibitory natural products lithospermic acid and integramycin, resulting in a formal total synthesis of the former. A modular, flexible and convergent synthetic strategy to lithospermic acid was devised. In this approach, a Sonogashira coupling was used to unite the C1–C7 and C20–C27 fragments that were subsequently manipulated to then participate in the key step of the synthesis, a palladium-mediated carbonylative annulation. Reduction of the benzofuran nucleus with magnesium in methanol then provided the desired dihydrobenzofuran core of lithospermic acid. Various protecting group strategies were investigated to complete this sequence in an efficient manner. Further synthetic manipulations afforded the complete C1–C9/C19–C27 fragment, which was united with the C10–C18 fragment to deliver the entire carbon skeleton of lithospermic acid. A two step deprotection sequence was undertaken, however, complications with the final deprotective step prevented definitive proof that the total synthesis of lithospermic acid had been achieved. An alternate protecting group strategy was sought, and a formal total synthesis of lithospermic acid was achieved by intercepting an advanced intermediate from a previous total synthesis. Several strategies for the enantioselective synthesis of the dihydrobenzofuran core of lithospermic acid were evaluated, however, none proved successful. A synthetic route towards the tetramic acid subunit of integramycin was also investigated. 3- Methoxymaleimide was constructed using known chemistry, and the regioselective reduction of this ring system was developed. Attempts to further functionalise this ring system were thwarted by difficulties associated with handling. The scope of the regioselective reduction was investigated on an array of N- substituted methoxymaleimides with the procedure found to be generally high yielding and highly regioselective.
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Fischer, Joshua. "HIV-1 Integrase Inhibitors: A Formal Total Synthesis of Lithospermic Acid And Synthetic Studies Towards Integramycin." University of Sydney, 2007. http://hdl.handle.net/2123/2397.

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Doctor of Philosophy (PhD)
This thesis describes synthetic studies towards the HIV-1 integrase inhibitory natural products lithospermic acid and integramycin, resulting in a formal total synthesis of the former. A modular, flexible and convergent synthetic strategy to lithospermic acid was devised. In this approach, a Sonogashira coupling was used to unite the C1–C7 and C20–C27 fragments that were subsequently manipulated to then participate in the key step of the synthesis, a palladium-mediated carbonylative annulation. Reduction of the benzofuran nucleus with magnesium in methanol then provided the desired dihydrobenzofuran core of lithospermic acid. Various protecting group strategies were investigated to complete this sequence in an efficient manner. Further synthetic manipulations afforded the complete C1–C9/C19–C27 fragment, which was united with the C10–C18 fragment to deliver the entire carbon skeleton of lithospermic acid. A two step deprotection sequence was undertaken, however, complications with the final deprotective step prevented definitive proof that the total synthesis of lithospermic acid had been achieved. An alternate protecting group strategy was sought, and a formal total synthesis of lithospermic acid was achieved by intercepting an advanced intermediate from a previous total synthesis. Several strategies for the enantioselective synthesis of the dihydrobenzofuran core of lithospermic acid were evaluated, however, none proved successful. A synthetic route towards the tetramic acid subunit of integramycin was also investigated. 3- Methoxymaleimide was constructed using known chemistry, and the regioselective reduction of this ring system was developed. Attempts to further functionalise this ring system were thwarted by difficulties associated with handling. The scope of the regioselective reduction was investigated on an array of N- substituted methoxymaleimides with the procedure found to be generally high yielding and highly regioselective.
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Sagiraju, Sarada. "Synthesis and Spectroscopic Study of Anticancer agent A-007 Prodrugs and Progress Towards the Synthesis of Tetramic acid Antibiotics." ScholarWorks@UNO, 2008. http://scholarworks.uno.edu/td/900.

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4, 4'-Dihydroxybenzophenone-2, 4-dinitrophenylhydrazone (A-007) has recently completed a phase-I clinical trial, and objective responses were seen in advanced breast cancer, lung cancer, ovarian cancer, melanoma, skin cancer and non-Hodgkin's lymphoma. Despite the promising results in the clinical trials, the major disadvantage to using A-007 as a broad-scale therapeutic is its poor water solubility. To make use of this promising anticancer drug either orally or intravenously, the short-term obstacle must be to overcome the limited solubility of A-007 in water. There are several approaches to overcome this obstacle. The first approach is to make hydrolysable prodrugs of A-007. The second approach is to make an A-007 complex with a water soluble host, such as cyclodextrin. We used a combination of these two previously described methods, i.e. transforming A-007 into a more water soluble prodrugs and then further increasing the prodrug water solubility by making their cyclodextrin inclusion complexes. Our syntheses and spectroscopic explorations of A-007 prodrugs are presented in this dissertation. Tetramic acid (2, 4 pyrrolidine-2, 4-dione ring system) containing compounds have been found to display a remarkable diversity of biological activities and have attracted the interest of medicinal and synthetic chemists. Magnesidin (1-acetyl-3-octanoyl-5-ethylidene tetramic acid) has strong antimicrobial activity against bacteria that cause gingivitis and dental plaque. Current efforts toward the synthesis of Magnesidin are discussed along with the plans for the completion of synthesis.
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Healy, Alan R. "Development of novel modulators of protein-protein interactions associated with cancer." Thesis, University of St Andrews, 2014. http://hdl.handle.net/10023/6316.

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An understanding of the underlying mechanisms by which proteins engage and communicate within the complex cellular environment is critical to the elucidation of the molecular basis of disease states and the development of safer, more efficacious drug therapies. Diverse cellular functions, including replication, transcription, cell growth and intracellular signal transduction, are governed by extensive networks of protein-protein interactions (PPIs). Disruption of the finely-tuned cellular networks due to the formation of aberrant or unregulated PPIs is implicated in the development and progression of cancer. As a result, over the last decade, PPI modulation has developed as an attractive molecular target for novel cancer therapies and as a powerful research tool in chemical biology to provide insight into the cellular transformations involved in carcinogenesis. Chapter 1 provides a review of the physiological importance of PPIs and the role they play in the development and progression of cancer. A summary of the challenges associated with targeting PPIs is given, highlighting the changing perception regarding the drugabbility of PPIs and the technological and conceptual advances driving this transformation. A brief overview of the approaches used to identify PPI modulators links the reader to the appropriate chapter for further discussion and utilisation of a selection of these methods. Chapter 2 describes the application of a virtual screening approach to discover PPI modulators. In particular, the development of an in silico – in vitro screening method to identify modulators of the protein interactome of the AAA+ protein reptin. The synthesis and optimisation of two hit compounds is outlined, with a discussion of their predicted binding modes, mode of action, potential as chemical tools and lead molecules for an anti-cancer drug discovery programme. Chapter 3 highlights the potential to discover PPI modulators from Nature's rich source of structurally complex, bioactive molecules. A synthetic approach to a sub-family of tetramic acid natural products is outlined, involving the development of a short, asymmetric synthesis of unnatural 4,4-disubstituted glutamic acid derivatives. The first total syntheses of the potent siderophore harzianic acid and the PAC3 PPI inhibitor JBIR-22 are reported. In addition, the potential role of a Diels-Alderase enzyme in the biosynthesis of JBIR-22 and the development of a chiral catalysed intramolecular Diels-Alder of an advanced JBIR-22 intermediate is investigated. Chapter 4 discusses the use of structure based design techniques in the development of PPI modulators. The process involved in the design of two series of inhibitors of PICK PDZ domain mediated interactions is outlined. This leads to the development and optimisation of synthetic routes to both series of inhibitors, including the utilisation of a strategic sp3-sp2 cross coupling reaction. Finally, preliminary biological assessment of the inhibitors is reported. Chapter 5 gives a brief overview of high-throughput screening (HTS) methods used to identify PPI modulators. The utilisation of a forward chemical genetics screen to identify the p53 activator MJ05 is described. A racemic and asymmetric route to MJ05 is developed and biochemical analysis of the two enantiomers of MJ05 is reported including the investigation of MJ05 as an adjuvant therapy for the treatment of cancer. Chapter 6 provides a general overview of the outcome of the different approaches used in this research to discover PPI modulators. Particular emphasis is placed on the development of chemical tools for the elucidation and dissection of the physiological role of protein-protein interactions and the identification of novel drug targets, in addition to the identification of lead molecules for PPI drug development programmes.
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Patience, J. M. "Routes to substituted tetramic acids." Thesis, University of Nottingham, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235998.

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Law, Ching-Man (Carole). "Novel tetramic acids via 1,3-dipolar cycloaddition." Thesis, Loughborough University, 2008. https://dspace.lboro.ac.uk/2134/34454.

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This Ph.D. thesis has been concerned with the reinvestigation and improvement of the intermolecular 1,3-dipolar cycloaddition strategy using isoxazoles, towards the 3-acyltetramic acids (3-acylpyrrrolidine-2,4-diones) and also the investigation and development of the corresponding intramolecular strategy. A second generation of the intermolecular route was developed previously within our group and we have synthesised a variety of pyrroloisoxazoles, the 'masked' tetramic acids. We have modified and improved both the isoxazole formations and the peptide coupling reactions; we have further developed the chain extension at the isoxazole C-5 (tetramic acid C-3) substituent, testing the aldol-type reaction with some aromatic aldehydes and extending it to aliphatic aldehydes. We have demonstrated the condensation method using a strong base and hydroxyl adducts were obtained. Dehydration has been undertaken to yield the alkenyl C-5 side-chain. Development of the desmethyllaccarin, a derivative of the natural product laccarin, has also been attempted via the intermolecular route. A potential intramolecular route has the reversed sequence from the intermolecular route, by using the N-acylation product produced from an amino acid for the formation of a nitrile oxide and hence our building block pyrroloisoxazole by intramolecular dipolar cycloaddition. We have generated a nitro ketoester compound from the amino acid and investigation on the synthesis of the pyrroloisoxazole has been undertaken.
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Books on the topic "Tetramic Acid"

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Nauen, Ralf. Aphid toxicology and plant systemic properties of an isecticidal tetramic acid derivative. Portsmouth: University of Portsmouth, School of Biological Sciences, 2002.

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Esch, G. J. van. Flame retardants: Tris(2-butoxyethyl) phosphate, tris(2-ethylhexyl) phosphate and tetrakis(hydroxymethyl) phosphonium salts. Geneva: World Health Organization, 2000.

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Saha, Jayanta Kumar. Total synthesis of (±)-bostrycin, synthesis of a chiral catechol-based C b2 s-symmetric ligand and studies directed towards the synthesis of dienoyl tetramic acid section of tirandamycin. 1986.

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van, Esch G. J., WHO Task Group on Environmental Health Criteria for Flame retardants: tris(2-butoxyethyl) phosphate, tris(2-ethylhexyl) phosphate and tetrakis(hydroxymethyl) phosphonium salt., United Nations Environment Programme, International Labour Organisation, World Health Organization, Inter-Organization Programme for the Sound Management of Chemicals., and International Program on Chemical Safety., eds. Flame retardants: Tris(2-butoxyethyl) phosphate, tris(2-ethylhexyl) phosphate and tetrakis(hydroxymethyl) phosphonium salts. Geneva: World Health Organization, 2000.

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Book chapters on the topic "Tetramic Acid"

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Gossauer, Albert. "Monopyrrolic Natural Compounds Including Tetramic Acid Derivatives." In Progress in the Chemistry of Organic Natural Products, 1–188. Vienna: Springer Vienna, 2003. http://dx.doi.org/10.1007/978-3-7091-6029-9_1.

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Lowery, Colin A., Gunnar F. Kaufmann, and Kim D. Janda. "Determination of Acyl Homoserine Lactone and Tetramic Acid Concentrations in Biological Samples." In Methods in Molecular Biology, 101–11. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-971-0_8.

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Jouin, P., B. Castro, J. Poncet, and D. Nisato. "SYNTHESIS OF CHIRAL TETRAMIC ACID. THE INTERMEDIATE IN THE STEREOCONTROLLED PREPARATION OF STATINE ANALOGUES. KEY COMPONENTS IN ASPARTIC PROTEINASES INHIBITORS." In Porto Carras, Chalkidiki, Greece, Aug. 31–Sept. 5, 1986, edited by Dimitrios Theodoropoulos, 659–62. Berlin, Boston: De Gruyter, 1987. http://dx.doi.org/10.1515/9783110864243-153.

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Plaza, A. I., S. O. Grim, R. J. Motekaitis, and A. E. Martell. "Ethylenebis(Nitrilodimethylene)Tetrakis-(Phenylphosphinic Acid)." In Inorganic Syntheses, 199–202. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470132470.ch54.

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Davis, Paul J., Faith B. Davis, Mary K. Luidens, Hung-Yun Lin, and Shaker A. Mousa. "Tetraiodothyroacetic Acid (Tetrac), Nanotetrac and Anti-angiogenesis." In Angiogenesis Modulations in Health and Disease, 107–17. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6467-5_10.

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Cox, Russell J. "The Biosynthesis of Polyketides, Tetramic Acids, and Pyridones in Fungi." In ACS Symposium Series, 33–47. Washington, DC: American Chemical Society, 2007. http://dx.doi.org/10.1021/bk-2007-0955.ch003.

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Winkelmann, Jochen. "Diffusion coefficient of tetraoctyl-stannane in silicic acid tetrakis[1-(methyl-d3)ethyl-1,2,2,2-d4] ester." In Diffusion in Gases, Liquids and Electrolytes, 1682–83. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-54089-3_1179.

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Winkelmann, Jochen. "Diffusion coefficient of tetramethoxy-silane in silicic acid tetrakis[1-(methyl-d3)ethyl-1,2,2,2-d4] ester." In Diffusion in Gases, Liquids and Electrolytes, 622. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-54089-3_365.

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Winkelmann, Jochen. "Diffusion coefficient of tetramethyl-stannane in silicic acid tetrakis[1-(methyl-d3)ethyl-1,2,2,2-d4] ester." In Diffusion in Gases, Liquids and Electrolytes, 631–32. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-54089-3_372.

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Winkelmann, Jochen. "Diffusion coefficient of tetra-(tert-butoxy)-titanium in silicic acid tetrakis[1-(methyl-d3)ethyl-1,2,2,2-d4] ester." In Diffusion in Gases, Liquids and Electrolytes, 1590–91. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-54089-3_1096.

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Conference papers on the topic "Tetramic Acid"

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Kohyama, Izumi, Chikara Dohno, Changfeng Hong, and Kazuhiko Nakatani. "Development of tetrameric naphthyridine derivatives for DNA and RNA containing a G-G mismatch." In XVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112367.

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Fuhlendorff, J., I. Clemmensen, and S. Magnusson. "PRIMARY STRUCTURE OF TETRANECTIN. SEQUENCE HOMOLOGY WITH ASIALOGLYCOPROTEIN RECEPTORS AND WITH PROTEOGLYCAN CORE PROTEIN FROM CARTILAGE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644380.

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Tetranectin (Mr = 68,000) is a tetrameric blood plasma protein, which binds to plasminogen and also to the lysine-binding site of the isolated kringle 4 from plasminogen. Its four polypeptide chains, which are non-covalently bound, each consists of 181 amino acid residues. We have determined the complete amino acid sequence and the disulfide bonds. Each position corresponds to a single amino acid residue except 34 which contains Ala and Ser and 37 which contains Val and Met in equimolar amounts. The three disulfide bonds connect Cys-50 to Cys-60, Cys-77 to Cys-176 and Cys-152 to Cys-168. The sequence of tetranectin was found to be homologous, to an extent indicating common ancestry, with the extracellular part of the asialoglyco-protein receptors and with the C-terminal globular domain of the cartilage proteoglycan core protein. Conserved residues include the six half-cystines of tetranectin. Therefore, we can now propose disulfide bond patterns for the proteins homologous with tetranectin. Supported by NIH-grant HL-16238 (S.M.), the Danish Science and Medical Research Councils, the Danish Cancer Society and NOVO Foundation.
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Ichinose, A., R. E. Bottenus, K. R. Loeb, and E. W. Davie. "ISOLATION AND CHARACTERIZATION OF THE GENES FOR THE a AND b SUBUNITS OF HUMAN COAGULATION FACTOR XIII." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644652.

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Factor XIII (plasma transglutaminase, fibrin stabilizing factor) is a plasma protein that plays an important role in the final stages of blood coagulation and fibrinolysis. The molecule occurs in blood as a tetramer (a2b2) consisting of two a. subunits and two b subunits. Recently, we have determined the amino acid sequences for both the a. and b subunits of human factor XIII by a combination of cDNA cloning and amino acid sequence analysis. cDNAs coding for the a (3.8 Kb) and b (2.2 Kb) subunits were used for the screening of human genomic DNA libraries. Among 12 × 106 recombinant phage, ∼30 have been shown to contain the sequences for the a subunit and ∼10 have been shown to contain the gene for the b subunit of factor XIII. The clones coding for the a. subunit span ∼90 Kb and have been characterized by restriction mapping. Southern blotting, and DNA sequencing. Both 5’ and 3’ ends of the genomic clones correspond to the 5’ and 3’portions of the cDNA for the a.subunit of factor XIII. The DNA sequence revealed that the activation peptide released ^thrombin (amino acid residues 137), the first putative Ca2+ binding region (around residue 251), the active Site Cys (amino acid residue 314), and the second putative Ca2+ binding region (around residue 473) are encoded by separate exons. Accordingly, the intervening sequences may separate the a subunit into functional and structural domains. The gene organization for the b subunit will also be presented. (Supported by NIH Grant HL 16919.)
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Erokhina, T. N., S. K. Zavriev, D. Y. Ryazantsev, and S. Y. Morozov. "PEPTIDES ENCODED BY PRECURSOR TRANSCRIPTS OF MICRO-RNAs IN PLANTS." In NOVEL TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. Institute of information technology, 2022. http://dx.doi.org/10.47501/978-5-6044060-2-1.78-86.

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The article discusses new data obtained in the study of the functions of a conservative peptide of cabbage plants, which is encoded by the microRNA156a. Comparative analysis of the nucleotide sequences of the promoter regions of these genes allowed us to identify a highly conserved 42-residue block located before the starting point of pri-miR156a transcription at a distance of 210-260 base pairs. It was found that promoter fragments containing a highly con-served block have a significantly higher ability to bind miPEP156a in vitro. We carried out mutagenesis of a highly conserved promoter block in its central part, which includes a tetramer of TG dinucleotides. It has been shown that the introduction of mutations into the promoter tetramer of TG dinucleotides significantly reduces the affinity of the promoter DNA to miPEP156a. The miPEPs revealed in plants have been found only in dicotyledons. The question of how miPEPs are distributed in other plant taxa is very important for understanding the evo-lutionary origin of such micropeptides. As an initial approach, we searched for taxonomically conservative miPEPs in mosses, since microRNAs have been studied in a great detail in the case of Physcomitrium patens moss. For two genes in the region preceding the Ppt-pre-miR160a sequence, rather short open reading frames were found that encoded peptides having a clear similarity of amino acid sequences in the central region. Importantly, such highly con-served peptide block homologous to that encoded by Ppt-miPEP160a gene was detected in short proteins encoded in pri-miR160a in almost 20 Bryopsida mosses.
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Davis, Paul J., Sudha Thangirala, Stewart Sell, Aleck Hercbergs, and Shaker A. Mousa. "Abstract LB-129: NDAT and P-bi-TAT formulations of tetraiodothyroacetic acid (tetrac) induce devascularization, necrosis and apoptosis in glioblastoma xenografts." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-lb-129.

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Hercbergs, Aleck A., Faith B. Davis, Paul J. Davis, and John T. Leith. "Abstract 3447: Tetrac (tetraiidothyroacetic acid) decreases in vitro x-ray survival of a human medullary thyroid cancer cell line under oxic and hypoxic conditions." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3447.

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Keasler, Vic, Brian Bennett, and Heather McGinley. "Analysis of Bacterial Kill Versus Corrosion From Use of Common Oilfield Biocides." In 2010 8th International Pipeline Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/ipc2010-31593.

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Bacterial proliferation is a severe problem in many oilfield systems, especially in aging systems with high water cuts. Depending on the types of microorganisms present, they can cause microbiologically influenced corrosion (MIC) or biofouling of filters, membranes, and metal surfaces. Common oilfield bacteria include sulfate-reducing bacteria (SRB) that can generate hydrogen sulfide (H2S) and iron sulfide (FeS) as a by-product (iron sulfide can occur in different structural forms), acid producing bacteria that can secrete organic acids that lower the pH within the microenvironment of a biofilm, as well as general heterotrophic bacteria that are often important in biofilm formation and maintenance, amongst others. To prevent corrosion or biofouling caused by these organisms, biocides are commonly added to the production fluids. Some concern has arisen that common oilfield biocides may be inherently corrosive at high end use concentrations and could cause general corrosion in the assets they are protecting from MIC. Accordingly, it is important to understand the risk of MIC, souring, and biofouling versus general corrosion from the biocides themselves. To examine the killing efficiency of oilfield biocides versus their corrosive potential, laboratory work was undertaken with five biocide products including: Tetrakis (hydroxymethyl) phosphonium sulfate (THPS), glutaraldehyde, glutaraldehyde / alkyldimethylbenzyl ammonium chloride (ADBAC) mixture, 5-chloro-2-methyl-4-isothiazolin-3-one/2-methyl-4-isothiazolin-3-one (CMIT/MIT), and a cocodiamine (quaternary amine). Each biocide was evaluated at four different concentrations ranging from 10–100,000 ppm of product. Killing efficiency was determined via bacterial kill studies, while wheelbox and bubble cell testing examined corrosion rates. Corrosion rates varied quite substantially from one biocide to the next, especially at high concentrations. Some biocides were found to be only mildly corrosive even at high dosages, while other biocides were much more corrosive at high concentrations. In general, it was observed that biocide corrosivity is directly related to the dosage of the biocide, with higher dosages correlating with higher corrosion rates. On the other hand, biocides were shown to be effective at killing common oilfield bacteria at relatively low dosages. This data suggests that biocides can be effective at killing bacteria at concentrations that do not cause significant amounts of general corrosion. Additionally, the common practice of batch treating biocides minimizes contact time between the biocide and the metal surface, which is in turn expected to minimize any corrosion that would otherwise be attributed to the biocides themselves. Taken together, this data would suggest that the benefit of biocide treatment to prevent MIC and biofouling substantially outweighs any potentially negative impact on corrosion.
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Fowles, Robert G., Simon J. M. Levey, and Clayton S. Smith. "An Advanced Method for Preparing Ferrous Sulfide and Testing Potential Inhibitors." In SPE International Oilfield Scale Conference and Exhibition. SPE, 2014. http://dx.doi.org/10.2118/spe-169808-ms.

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Abstract Ferrous-sulfide (iron II sulfide) scale typically forms in the wellbore under anaerobic conditions and may cause a reduction in well productivity. It has been proposed that ferrous ions react with bisulfide formed from dissolved hydrogen sulfide to form a complex iron bisulfide intermediate, which further reacts to produce black solid ferrous sulfide. Treatment of this type of scale typically involves mineral acids or chelants, which themselves provide additional challenges for pipeline integrity. The Weatherford flow assurance laboratory carries out tests that determine the best inhibitors for scale problems. Compared to calcite, barium, and gypsum scales, little work has been done to study prevention of ferrous sulfide scale. For calcite, barium, and gypsum scales, the dynamic-flow loop is commonly used. However, for ferrous-sulfide scale, there is a challenge for a quick and reliable test method. The preparation of ferrous sulfide under sour conditions is not straight forward due to both the difficulty in achieving sufficiently anaerobic conditions and the associated hazards of managing H2S. The presence of oxygen will result in ferric sulfide instead of ferrous sulfide. This paper describes in detail laboratory experiments to safely prepare ferrous sulfide scale using H2S and also test potential inhibitors. Comparisons were made between using metal sulfide instead of H2S. Using the H2S method to prepare ferrous sulfide provided a quick and robust way to select potential inhibitors under various conditions, which can be used to improve flow assurance assessments. This paper will demonstrate selected chemicals compared to tetrakis (hydroxymethyl) phosphonium sulfate (THPS) in preventing the formation of ferrous sulfide under sour conditions and ambient or elevated pressures and temperatures when applied at low concentrations. Some inhibitors that are successful under sour ferrous sulfide preparations are not effective when metal sulfide ions are used instead of H2S, which means potential inhibitors are being missed due to inappropriate test methods. Overall, a technological advancement was made with an anaerobic and sour method to test effectively ferrous sulfide inhibitors that would perform at low concentrations.
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Hercbergs, Aleck A., Hung-Yun Lin, Faith B. Davis, Paul J. Davis, and John T. Leith. "Abstract 2673: Tetraiodothyroacetic acid (tetrac) produces an increase in the unirradiated steady-state levels of DNA double strand breaks (DSBs) and inhibition of repair of DSBs after x-irradiation in human U87MG brain tumor cells." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-2673.

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