Relevant bibliographies by topics / Tetrahydroisoquinolines

Academic literature on the topic 'Tetrahydroisoquinolines'

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Published: 4 June 2021
Last updated: 20 July 2024

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Journal articles on the topic "Tetrahydroisoquinolines"

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Ponzo, Viviana L., and Teodoro S. Kaufman. "Synthesis of 3-substituted tetrahydroisoquinolines by acid-catalyzed cyclization of p-toluenesulfonamides of N-benzyl aminoacetaldehyde derivatives." Canadian Journal of Chemistry 73, no. 8 (August 1, 1995): 1348–56. http://dx.doi.org/10.1139/v95-166.

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The acid-catalyzed cyclization of p-toluenesulfonamides of N-benzyl aminoacetaldehyde, or their acetalic counterparts, usually yields 1,2-dihydroisoquinolines. However, cyclization of intermediates bearing a substituent α to the carbonyl group affords 3-substituted 2-p-toluenesulfonyl tetrahydroisoquinolin-4-ol derivatives, capable of further transformation into the related 1,2,3,4-tetrahydroisoquinolines. Keywords: 3-substituted tetrahydroisoquinolines, MY336-a analog, acid-catalyzed cyclization, tetrahydroisoquinolin-4-ol derivatives.
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Kmieciak, Anna, Marta Ćwiklińska, Karolina Jeżak, Afef Shili, and Marek P. Krzemiński. "Searching for New Biologically Active Compounds Derived from Isoquinoline Alkaloids." Chemistry Proceedings 3, no. 1 (November 14, 2020): 97. http://dx.doi.org/10.3390/ecsoc-24-08417.

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Many isoquinoline alkaloids are biologically active compounds and successfully used as pharmaceuticals. Compounds belonging to the isoquinolines and tetrahydroisoquinolines (TIQs) can be used as anesthetics, antihypertensive drugs, antiviral agents, and vasodilators. In the presented studies, the search for new compounds and synthesis of tetrahydroisoquinoline alkaloid derivatives was undertaken. Several dihydroisoquinolines were synthesized by Bishler–Napieralski reaction from the corresponding amides. Dihydroisoquinolines were reduced with sodium borohydride to obtain racemic tetrahydroisoquinolines. Asymmetric reduction of selected 3,4-dihydroisoquinolines was attempted with borane in the presence of chiral terpene spiroboranes.
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Forni, José Augusto, Martin Brzozowski, John Tsanaktsidis, G. Paul Savage, and Anastasios Polyzos. "Rapid Microwave-Assisted Synthesis of N-Aryl 1,2,3,4-Tetrahydroisoquinolines." Australian Journal of Chemistry 68, no. 12 (2015): 1890. http://dx.doi.org/10.1071/ch15490.

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N-aryl 1,2,3,4-tetrahydroisoquinolines were prepared rapidly in good yields by the microwave-assisted Pd-catalysed coupling of (hetero)aryl iodides or bromides with 1,2,3,4-tetrahydroisoquinoline. Reactions were typically complete within 5 min for aryl iodides and within 30 min for pyridyl bromides.
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Ding, Ming-Wu, Long Zhao, Mao-Lin Yang, and Mei Sun. "One-Pot Synthesis of 3-(1,2,3,4-Tetrahydroisoquinolin-1-yl)-isoquinolin-1(2H)-ones by DEAD-Promoted Oxidative Ugi–Wittig ­Reaction Starting from Phosphonium Salt Precursors." Synlett 33, no. 01 (October 4, 2021): 66–69. http://dx.doi.org/10.1055/a-1661-3378.

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AbstractA new one-pot synthesis of 3-(1,2,3,4-tetrahydroisoquinolin-1-yl)-isoquinolin-1(2H)-ones by DEAD-promoted oxidative Ugi–­Wittig reaction was developed. The sequential reactions of (2-carboxybenzyl)triphenylphosphonium salts, isocyanides, and N-aryl-1,2,3,4-tetrahydroisoquinolines produced 3-(1,2,3,4-tetrahydroisoquinolin-1-yl)-isoquinolin-1(2H)-ones in moderate to good overall yields in the presence of DEAD and Et3N.
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Azamatov, Azizbek A., Sherzod N. Zhurakulov, Valentina I. Vinogradova, Firuza Tursunkhodzhaeva, Roaa M. Khinkar, Rania T. Malatani, Mohammed M. Aldurdunji, Antonio Tiezzi, and Nilufar Z. Mamadalieva. "Evaluation of the Local Anesthetic Activity, Acute Toxicity, and Structure–Toxicity Relationship in Series of Synthesized 1-Aryltetrahydroisoquinoline Alkaloid Derivatives In Vivo and In Silico." Molecules 28, no. 2 (January 4, 2023): 477. http://dx.doi.org/10.3390/molecules28020477.

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Isoquinoline alkaloids constitute one of the most common classes of alkaloids that have shown a pronounced role in curing various diseases. Finding ways to reduce the toxicity of these molecules and to increase their therapeutic margin is an urgent matter. Here, a one-step method for the synthesis of a series of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines was performed in 85–98% yield by the Pictet–Spengler reaction. This was accomplished using the reaction between 3,4-dimethoxyphenylethylamine and substituted benzaldehydes boiling in trifluoroacetic acid. Furthermore, 1-(3′-amino-, 4′-aminophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines were obtained in 94% and 97% yield by reduction in 1-(3′-nitro-, 4′-nitrophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines with SnCl2 × 2H2O. The structures of the substances obtained were confirmed by infrared (IR) and nuclear magnetic resonance (1H and 13C NMR) spectra. ADMET/TOPKAT in silico study concluded that the synthesized compounds exhibited acceptable pharmacodynamic and pharmacokinetic properties without carcinogenic or mutagenic potential but with variable hepatotoxicity. The acute toxicity and structure–toxicity relationship (STR) in the series of 20 derivatives of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines (3a-r, 4a, b) was studied via determination of acute toxicity and resorptive action in white mice employing intragastric step-by-step administration. The first compound, 1-phenyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (3a), showed the highest toxicity with LD50 of 280 mg/kg in contrast to 1-(3′-bromo -4′-hydroxyphenyl)-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (3e) which proved to be the safest of the compounds studied. Its toxicity was 13.75 times lower than that of the parent compound 3a. All compounds investigated showed high local anesthetic activity on rabbit eyes in the concentrations studied. Only 3r, 3n, and 4a caused eye irritation and redness. All investigated derivatives (except 4b) in 1% concentration were more active than lidocaine, providing longer duration of complete anesthesia. Therefore, based on the obtained results of in silico tests, local anesthesia, and acute toxicity, a conclusion can be drawn that the experimental compounds need further extensive future investigations and possible modifications so that they can act as promising drug candidates.
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Ji, Jian, Ling-Yan Chen, Zi-Bin Qiu, Xinfeng Ren, and Ya Li. "Metal-Free Oxidative Coupling of Tetrahydroisoquinolines and 3-Fluorooxindoles on Water." Synthesis 52, no. 03 (October 21, 2019): 471–78. http://dx.doi.org/10.1055/s-0039-1690213.

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An efficient, metal-free oxidative coupling of tetrahydroisoquinolines and 3-fluorooxindoles on water has been developed. Using aqueous tert-butyl hydroperoxide as the oxidant, Et3N as the base, and water as the sole solvent, a variety of 3-fluorooxindoles fully substituted at the 3-position and containing a tetrahydroisoquinoline fragment has been successfully prepared in yields of up to 93% with an anti/syn stereo­selectivity of up to 99:1 under very mild and safe reaction conditions.
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Lipeeva, Alla V., Arkady O. Brysgalov, Tatyana G. Tolstikova, and Elvira E. Shults. "Synthesis, Transformations and Characterization of 8 Aminomethyl Substituted Umbelliferones as Probable Anti-Arrhythmic Agents." Current Bioactive Compounds 15, no. 1 (February 6, 2019): 71–82. http://dx.doi.org/10.2174/1573407213666171030152601.

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Background: Coumarin and modified nitrogen heterocyclic nuclei show biological activity. Combining these into a hybrid molecule could lead to new pharmacological agents. A series of hybrid compounds combining coumarin and piperidine, piperazine, purine or tetrahydroisoquinoline moieties were synthesized and evaluated for anti-arrhythmic activity. Methods: The Mannich reaction of coumarins (peurutenicin, peucenol and 6-cyanoumbelliferrone) with formaldehyde and various amines, including several alkaloids – anabasine, theophylline or tetrahydroisoquinolines, proceeds by heating under reflux in dioxane in the presence of 4-dimethylaminopyridine. The Suzuki reaction of 6,8-disubstituted umbelliferone triflate was used for the introduction of an aryl substituent in position 7 of the the coumarin framework. Results: Twenty two novel coumarin-based Mannich bases were synthesized via introduction of functional aminomethyl group at position 8 of 6 substituted 7-hydroxy-2H-chromen-2-ones by Mannich reaction. The results illustrated that the C-6 and C-8 substituents’ effect was obvious in our designed system and there was a relationship between the structures and the anti-arrhythmic activity of the 6,7,8- trisubstituted coumarins. 8-(6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-tetrahydroisoquinolinylmethyl)- substituted peucenol derivatives shown in vivo a pronounced and selective anti-arrhythmic activity on epinephrine arrhythmias in comparison with natural coumarin peucenol. The moderate toxicity of the new compound encouraged further design of therapeutically relevant analogues based on this novel type of coumarin- tetrahydroisoquinoline hybrids. Conclusion: We have developed a mild reaction protocol to synthesize new mannich products on the basis of substituted coumarins. The anti-arrhythmic activity of coumarin-tetrahydroisoquinoline hybrids was revealed. We report for the first time that coumarin containing 8-(1-(3,4,5-trimethoxyphenyl) tetrahydroisoquinolinyl)methyl) substituent offer a suitable scaffold for the development of novel anti-arrhythmic agents.
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Clark, Robin D., Jahangir, and James A. Langston. "Heteroatom-directed lateral lithiation: synthesis of isoquinoline derivatives from N-(tert-butoxycarbonyl)-2-methylbenzylamines." Canadian Journal of Chemistry 72, no. 1 (January 1, 1994): 23–30. http://dx.doi.org/10.1139/v94-005.

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Methodology for the preparation of isoquinoline derivatives from N-(tert-butoxycarbonyl)-2-methylbenzylamines (1) was developed. Conversion of 1 to the dilithio species followed by condensation with DMF afforded Boc-3-hydroxy-1,2,3,4-tetrahydroisoquinolines 3, which could be dehydrated to 1,2-dihydroisoquinolines 4. Hydrogenation of dihydro compounds 4 afforded the corresponding tetrahydroisoquinolines 5. Treatment of the dilithio species from 1 with N-methoxy-N-methylamides afforded ketones 14, which were converted to 3-substituted dihydro-isoquinoline 15, tetrahydroisoquinolines (16, 17), or isoquinolines (20).
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Mosca, Luciana, Carla Blarzino, Raffaella Coccia, Cesira Foppoli, and Maria Anna Rosei. "Melanins From Tetrahydroisoquinolines." Free Radical Biology and Medicine 24, no. 1 (January 1998): 161–67. http://dx.doi.org/10.1016/s0891-5849(97)00211-6.

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Arustamyan, Zh S., R. E. Margaryan, A. A. Aghekyan, G. A. Panosyan, G. S. Mkrtchyan, and R. E. Muradyan. "Synthesis and antiarrhythmic activity of a new benzodioxolsubstituted 4-spirocycloalkan(tetrahydropyran)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines." Журнал органической химии 59, no. 11 (December 15, 2023): 1446–54. http://dx.doi.org/10.31857/s051474922311006x.

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By the reaction of 1-(3,4-dimethoxy)phenylcycloalkanmethan- and 4-(3,4-dimethoxyphenyl)tetrahydropyran-4-methanamines with benzo[ d ][1,3]dioxol-5-carbonyl chloride corresponding N -substituted benzo[ d ][1,3]dioxol-5-carboxamides were synthesized. Cyclization of the latter with phosphorus oxychloride gave dihydroisoquinolines reduced with sodium borohydride to the corresponding spiro-substituted tetrahydroisoquinolines, whose methylation according to Eschweiler-Clark reaction gave N -methyl derivatives. By condensation abovementioned amines with benzo[ d ][1,3]dioxol-5-carbaldehyde Schiff bases were synthesized. The reduction of the latter with sodium borohydride gave the corresponding secondary amines - non-cyclic analogues of tetrahydroisoquinolines, which undergo cyclization under the conditions of the Eschweiler-Clark reaction to form N -benzodioxolmethyl-substituted tetrahydroisoquinolines.
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Dissertations / Theses on the topic "Tetrahydroisoquinolines"

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Talk, Ruaa. "Deprotonation-substitution of N-Boc-tetrahydroisoquinolines." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19202/.

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Tetrahydroisoquinolines (THIQs) are found in a wide range of natural products and compounds with biological activity. This thesis describes the methodology of deprotonation‒substitution as an efficient route to 1-substituted THIQs and 3-substituted THIQs. This methodology was developed by using organolithium and organomagnesium chemistry. Firstly, methods were developed for the lithiation–substitution of tetrahydroisoquinolines by carrying out in situ ReactIR spectroscopic monitoring of deprotonation reactions. Moderate to high yields of products were obtained under the optimum reaction conditions. The lithiation‒substitutions of tetrahydroisoquinolines A were carried out. This chemistry was applied to a short synthesis of the alkaloids (±)-dysoxyline and (±)-crispine A. The lithiation–substitution of N-Boc-3-phenyltetrahydroisoquinoline B was also investigated. Lithiation was found to occur with approximately a 2:1 ratio at C-1 to C-3. NMR studies and DFT analysis were carried out in order to calculate the ratio of the two rotamers of B. Investigations have also focused on N-Boc-3-cyanotetrahydroisoquinoline and N-Boc-2-cyanopyrrolidine. High enantioselectivities of the forming products could be obtained from the sequence of deprotonation–substitution of these compounds at –104 ºC using magnesium bases. Altering the solvent was shown to have a large impact on the yield and enantioselectivity of the products.
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Li, Xiabing. "Synthesis of substituted tetrahydroisoquinolines using lithiation-substitution." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/6431/.

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Berg, Michael Arthur George. "Studies in the stereoselective synthesis of 1,1-disubstituted 1,2,3,4-tetrahydroisoquinolines." Diss., This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-10032007-171522/.

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Strange, Rosalind H. "Studies towards the synthesis of functionalised 1,2,3,4-tetrahydroisoquinolines." Thesis, University of Bath, 1994. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760650.

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Jones, Michael William Chemistry Faculty of Science UNSW. "Enhancing the cooperative binding properties of 1,1'-bis(1,2,3,4-tetrahydroisoquinolines)." Awarded by:University of New South Wales. School of Chemistry, 2005. http://handle.unsw.edu.au/1959.4/27400.

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The design of partially reduced 1,1'-bisisoquinoline derivatives was investigated with the aim of controlling the conformation about the C1-C1' axis. This would produce ligands with unusual but predictable ligand binding properties, particularly cooperativity. The introduction of ??-aminoalkyl, ??-azidoalkyl, ??-alkynyl and ??-alkenyl groups onto the nitrogens of the reduced bisisoquinoline core was conducted with the intention of broadening the scope of the ligand. Subsequent epoxidation, hydroboration and Huisgen 1,3-dipolar cycloaddition of terminal unsaturated groups and nucleophilic displacement of the chlorine of the corresponding known bischloroacetyl derivative afforded representative examples of new ligand types for future study. 1,1'-Bis(1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline) was found to readily condense with a wide range of aldehydes to give imidazolines and aspects of the rates of condensation were determined. Mono-alkyl bisisoquinolines were obtained efficiently by cleavage of the imidazolines through a newly defined treatment with sodium cyanoborohydride under acidic conditions. A procedure was developed whereby these two steps could be accomplished in a sequential one-pot process. The mono-alkyl compounds were further derivatized through acetylation, alkylation, sulfonylation and reductive alkylation. Synthetic strategies towards ??-excessive N-arenealkyl derivatives were established with the goal to create scaffolds for the coordination of ??-deficient systems, of which the X-ray crystal structures of three N-arenemethyl derivatives were elucidated. These are each closely related in conformation about the C1-C1' axis. Reaction of two examples of the N-arenealkyl compounds with copper(II) and palladium(II) chlorides, furnished the first known examples of this type of highly reduced 1,1'-bisisoquinoline-metal complex. Single crystal X-ray crystallography was used to analyse the structures of these complexes in the solid state. Preliminary physicochemical investigations were conducted with a view to determining the conformation of the molecules about the bisisoquinoline C1-C1' bond. The interaction of intermolecular N-aryl ??-excessive compounds with ??-deficient systems was found to result in minimal spectroscopic changes. Complementary intramolecular ??-excessive/??-deficient systems were found through fluorometric analysis to readily form charge transfer complexes. Finally, it was determined that the conformation of 1,1'-bis[2-(methoxy-18- crown-6)ethanoyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline] could be controlled by the simultaneous coordination of the termini of the diperchlorate salt of 1,3-diaminopropane to the crown ether moieties of the ligand. A range of new N-substituted bisisoquinolines have been synthesised and methods developed for determining interactions between parts of these molecules that through these physicochemical characteristics could allow monitoring of conformational behaviour in future studies. Keywords: 1,1'-bisisoquinoline, conformational analysis, supramolecular chemistry, functional ligands, metal complexes.
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MacLeod, Patricia. "Synthesis of chiral tetrahydroisoquinolines and their applications in asymmetric catalysis." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86796.

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This thesis describes an investigation on the synthesis of chiral 1,2,3,4-tetrahydroisoquinoline-based amino alcohols (THIQNOLs) and their use as chiral ligands.
The synthesis of these structures using an aza-Friedel-Crafts reaction between 3,4-dihydroisoquinoline and naphthols is described in the first part of the thesis. By design, this process occurs without added catalyst and serves as a proof of concept for greener (or self-catalytic) catalysis. The reactions can be carried out either in absence of solvent or by using water as solvent.
The second part of this thesis describes the synthesis of optically enriched THIQNOLs for their use as chiral ligands. The first generation of ligands is a set of tertiary amino alcohols, which were applied to the asymmetric addition of diethylzinc to aldehydes. The second generation of ligands is a set of secondary amino alcohols and these were also applied to the asymmetric addition of diethylzinc to aldehydes, improving on the results achieved with the first generation.
La présente thèse a pour but, l'étude de la synthèse des composés de type 1,2,3,4-tetrahydroisoquinoline portant une fonctionnalité amino-alcool (THIQNOLs). Grâce à cette fonctionnalité, il est possible d'utiliser ces composés comme ligands chiraux en synthèse asymétrique.
La première partie de la thèse décrit la synthèse racémique de ces composés en utilisant la réaction aza-Friedel-Crafts entre les 3,4-dihydroisoquinolines et les naphthols. Ce procédé ne nécessite ni catalyseur, ni réactif stochiométrique. Cette réaction sert de preuve de concept qu'une catatyse plus ''verte'' (ou auto-catalysée) est possible. En général, ces réactions ne nécessitent pas de solvant, bien que l'eau peut être utilisée.
La seconde partie de la thèse décrit la synthèse asymétrique des composés THIQNOLS ainsi que leur utilisation en tant que ligand chiraux pour l'addition asymétrique du diethylzinc aux aldehydes. La première génération des ligands est basée sur les amino-alcool tertiaires, alors que la deuxième génération repose sur les amino-alcool secondaires. Les résultats obtenus pour les ligands de la deuxième génération sont, en général, supérieur à ceux de la première génération.
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Brar, Satjit Singh. "Effects of Smoking and Gender on Tetrahydroisoquinolines and Beta-Carbolines in a Healthy Population and During Alcohol Detoxification." VCU Scholars Compass, 2008. http://hdl.handle.net/10156/1561.

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Frost, Aileen Bernadette. "Aziridines and aziridinium intermediates in the asymmetric synthesis of beta-substituted-alpha-amino acids and 1,2,3,4-tetrahydroisoquinolines." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:ab3aa702-caab-4d20-9057-028258be5fdb.

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This thesis is concerned with the development of methodology for the regioselective ring-opening of aziridines and aziridinium intermediates and its subsequent application to the asymmetric synthesis of β-substituted-α-amino acids and 1,2,3,4-tetrahydroisoquinolines. Chapter 1 introduces methods for the formation of aziridines and aziridinium ions and focusses on their utility as intermediates in synthesis. Chapter 2 describes studies into the synthesis of aziridines from enantiopure α-hydroxy-β-amino esters and their subsequent conversion to the corresponding β-hydroxy-α-amino acids via either a regioselective ring-opening with Cl3CCO2H, or a rearrangement promoted by Cl3CCO2H. Application of this procedure to both syn- and anti-configured substrates enabled the syntheses of (S,S)-allo-threonine, (2R,3S)-threonine, (R,R)-3-hydroxyphenylalanine and (2S,3R)-3-hydroxyphenylalanine. Chapter 3 details attempts to truncate the synthesis described in Chapter 2 by investigating the synthesis of enantiopure anti-β-hydroxy-α-amino acids via the intermediacy of aziridinium ions. These studies culminated in the development of a regioselective and stereospecific one-pot aziridinium formation and ring-opening protocol, leading to the synthesis of a range of C(3)-aryl and C(3)-alkyl substituted anti-β-hydroxy-α-amino acids. Chapter 4 discusses the conversion of enantiopure anti-α-hydroxy-β-amino esters to anti-β-fluoro-α-amino esters via the regioselective and stereospecific ring-opening of an aziridinium intermediates in situ. The subsequent development of a one-pot deprotection strategy leads to a concise and expedient synthesis of anti-β-fluorophenylalanines. The extension of this methodology to access a representative anti-α,β-diamino acid is also demonstrated. Chapter 5 describes the development of a one-pot diastereoselective rearrangement of enantiopure α-hydroxy-β-amino esters to 1,2,3,4-tetrahydroisoquinolines. The substrate scope of this reaction manifold is examined and application to the asymmetric synthesis of enantiopure 1,2,3,4-tetrahydroisoquinolines also discussed. Chapter 6 contains full experimental procedures and characterisation data for all compounds synthesised in Chapters 2, 3, 4 and 5.
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Erdmann, Vanessa [Verfasser], Dörte Akademischer Betreuer] Rother, and Lars Mathias [Akademischer Betreuer] [Blank. "Synthetic enzyme cascades for the synthesis of amino alcohols and tetrahydroisoquinolines / Vanessa Erdmann ; Dörte Rother, Lars Mathias Blank." Aachen : Universitätsbibliothek der RWTH Aachen, 2018. http://d-nb.info/121159081X/34.

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Erdmann, Vanessa Verfasser], Dörte [Akademischer Betreuer] Rother, and Lars Mathias [Akademischer Betreuer] [Blank. "Synthetic enzyme cascades for the synthesis of amino alcohols and tetrahydroisoquinolines / Vanessa Erdmann ; Dörte Rother, Lars Mathias Blank." Aachen : Universitätsbibliothek der RWTH Aachen, 2018. http://d-nb.info/121159081X/34.

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Books on the topic "Tetrahydroisoquinolines"

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Hedley, Kenneth Andrew. Aspects of the chemistry of 1, 2, 3, 4- tetrahydroisoquinoline. 1997.

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Book chapters on the topic "Tetrahydroisoquinolines"

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Rommelspacher, H., and R. Susilo. "Tetrahydroisoquinolines and β-carbolines: putative natural substances in plants and mammals." In Progress in Drug Research, 415–59. Basel: Birkhäuser Basel, 1985. http://dx.doi.org/10.1007/978-3-0348-9315-2_10.

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Ortiz Villamizar, Marlyn C., Carlos E. Puerto Galvis, and Vladimir V. Kouznetsov. "The C-1 Functionalization of Tetrahydroisoquinolines via Cross-Dehydrogenative Coupling Reactions." In Heterocycles via Cross Dehydrogenative Coupling, 77–105. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-9144-6_3.

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Suzuki, K., Y. Mizuno, M. Naoi, T. Nagatsu, and M. Yoshida. "Inhibitory Effects of Endogenous Tetrahydroisoquinolines on Mitochondrial Respiration in Mouse Brain." In Alzheimer’s and Parkinson’s Diseases, 569–74. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4757-9145-7_82.

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Nappi, A. J., E. Vass, and M. A. Collins. "The Effects of Catecholic and O-Methylated Tetrahydroisoquinolines on the Production of Hydroxyl Radical." In Neurotoxic Factors in Parkinson’s Disease and Related Disorders, 323. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-1269-1_43.

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Vetulani, J., I. Nalepa, L. Antkiewicz-Michaluk, and M. Sansone. "Opposite Effects of Simple Tetrahydroisoquinolines on Amphetamine and Morphine-Stimulated Locomotor Activity in Mice." In Neurotoxic Factors in Parkinson’s Disease and Related Disorders, 326. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-1269-1_46.

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Li, Jie Jack. "Pictet-Spengler tetrahydroisoquinoline synthesis." In Name Reactions, 314. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05336-2_234.

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Li, Jie Jack. "Pictet–Spengler tetrahydroisoquinoline synthesis." In Name Reactions, 480–81. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03979-4_215.

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Li, Jie Jack. "Pictet–Spengler tetrahydroisoquinoline synthesis." In Name Reactions, 1–2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-01053-8_201.

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Li, Jie Jack. "Pictet–Spengler Tetrahydroisoquinoline Synthesis." In Name Reactions, 443–45. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-50865-4_121.

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Pagel, Peter, Rainer Schubert, Christoph Wilhelm, and Hans-Uwe Wolf. "Development of an HPLC-Method and Synthesis of 1,2,3,4-Tetrahydroisoquinolines as Reference Compounds for the Identification of Possible Neurotoxins in the Blood of Parkinson’s Disease Patients." In Neurotoxic Factors in Parkinson’s Disease and Related Disorders, 111–14. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-1269-1_12.

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Conference papers on the topic "Tetrahydroisoquinolines"

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Redda, Kinfe Ken, Madhavi NA Gangapuram, and Tiffany W. Ardley. "Abstract 735: Synthesis of substituted 1,2,3,4-tetrahydroisoquinolines as anticancer agents." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-735.

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DENIAU, Eric, and Stéphane LEBRUN. "Asymmetric photoinduced electrocyclic ring closure of chiral aromatic enehydrazides. Application to the asymmetric synthesis of 3-aryl dihydroisoquinolones and tetrahydroisoquinolines." In The 19th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2015. http://dx.doi.org/10.3390/ecsoc-19-a031.

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Redda, Kinfe Ken, Madhavi Gangapuram, and Suresh Eyunni. "Abstract 173: Synthesis of substituted tetrahydroisoquinoline derivatives as anticancer agents." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-173.

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Miller, Eric J., Petra Gregorova, Carrie Q. Sun, Leon Jacobs, Zafer Sahin, Yesim Altas Tahirovic, Samantha L. Burton, et al. "Tetrahydroisoquinoline-Based Small Molecule Inhibitors of the Chemokine Receptor CXCR4." In ASPET 2024 Annual Meeting Abstract. American Society for Pharmacology and Experimental Therapeutics, 2024. http://dx.doi.org/10.1124/jpet.291.127096.

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Leese, Mathew P., Fabrice L. Jourdan, Eric Ferrandis, Sandra Regis-Lydi, Philip G. Kasprzyk, Ann Fiore, Simon P. Newman, et al. "Abstract 756: Optimization of tetrahydroisoquinoline-based microtubule disruptors as anticancer agents." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-756.

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Redda, Kinfe Ken, Madhavi Gangapuram, Wang Zhang, and Suresh Eyunni. "Abstract 514: Design and synthesis of substituted tetrahydroisoquinoline derivatives as an antibreast cancer agents." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-514.

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Wang, Ran, Wei Yang, Yujing Luan, Jian Mao, Hong Qing, and Yulin Deng. "Salsolinol, a Dopamine-derived Tetrahydroisoquinoline, Occur in Dopaminergic SH-SY5Y Cells Induced by Dopamine." In 2007 IEEE/ICME International Conference on Complex Medical Engineering. IEEE, 2007. http://dx.doi.org/10.1109/iccme.2007.4381975.

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Redda, Kinfe Ken, Madhavi Gangapuram, and Suresh Eyuinni. "Abstract 22: Design and synthesis of substituted tetrahydroisoquinoline derivatives as anti-angiogenic and anti-breast cancer agents." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-22.

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Redda, Kinfe Ken, Madhavi Gangapuram, and Suresh Eyuinni. "Abstract 22: Design and synthesis of substituted tetrahydroisoquinoline derivatives as anti-angiogenic and anti-breast cancer agents." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-22.

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Gámez-Montaño, Rocío, Manuel A. Rentería-Gómez, and Alejandro Islas-Jácome. "Synthesis of 1-tetrazolyl-1,2,3,4-tetrahydroisoquinoline bound-type bis-heterocycles via oxidative Ugi-azide reaction." In The 20th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2016. http://dx.doi.org/10.3390/ecsoc-20-a030.

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