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Journal articles on the topic 'TET protease'

Author: Grafiati

Published: 4 May 2024

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1

Ishikawa, Chika, Tatsuya Tsuda, Hiroe Konishi, Noboru Nakagawa, and Kiyofumi Yamanishi. "Tetracyclines Modulate Protease-Activated Receptor 2-Mediated Proinflammatory Reactions in Epidermal Keratinocytes." Antimicrobial Agents and Chemotherapy 53, no. 5 (2009): 1760–65. http://dx.doi.org/10.1128/aac.01540-08.

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ABSTRACT In addition to their antibiotic effects, tetracyclines have anti-inflammatory action that is often beneficial in the control of inflammatory skin disorders. In this study, we examined the effects of tetracycline (TET) and two of its derivatives, doxycycline (DOX) and minocycline (MIN), on the production of interleukin-8 (IL-8) elicited by the activation of protease-activated receptor 2 (PAR2) in normal human epidermal keratinocytes (NHEK). In NHEK, the production of IL-8 stimulated by an agonist peptide of PAR2, SLIGKIV-NH2, at 100 μM was significantly reduced by TET, DOX, or MIN at 5

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2

Wang, Chun-hui, Jia-min Yang, Yu-bo Guo, Jing Shen, and Xiao-hua Pei. "Anticancer Activity of Tetrandrine by Inducing Apoptosis in Human Breast Cancer Cell Line MDA-MB-231 In Vivo." Evidence-Based Complementary and Alternative Medicine 2020 (June 30, 2020): 1–11. http://dx.doi.org/10.1155/2020/6823520.

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Tetrandrine (TET) is an alkaloid extracted from a traditional Chinese medicinal plant. It exerts remarkable anticancer activity and induces apoptotic cell death in various human cancer cells. The present study aimed to investigate the effects of TET on the inhibition of tumor growth and the induction of apoptosis in MDA-MB-231 breast cancer in xenograft mice. Tumor weight and volume were measured. The histopathological changes in the tumor tissue were observed. Immunohistochemistry analysis of Bcl-2-associated X protein (Bax) and B-cell lymphoma/leukemia-2 (Bcl-2) was carried out. The expressi

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3

Borissenko, Ljudmila, and Michael Groll. "Crystal Structure of TET Protease Reveals Complementary Protein Degradation Pathways in Prokaryotes." Journal of Molecular Biology 346, no. 5 (2005): 1207–19. http://dx.doi.org/10.1016/j.jmb.2004.12.056.

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4

Chow, W. A., S. Guo, and F. Valdes-Albini. "HIV protease inhibitor (PI) therapy for liposarcoma." Journal of Clinical Oncology 24, no. 18_suppl (2006): 9564. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.9564.

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9564 Background: Liposarcomas are the second most common soft-tissue sarcoma. Highly-active anti-retroviral therapy (HAART) with HIV PIs results in “HIV-1 protease inhibitor associated lipodystrophy syndrome,” characterized by peripheral fat wasting, central fat accumulation, insulin resistance, and hyperlipidemia. Based upon this syndrome, we hypothesized that HIV PIs might represent a novel liposarcoma therapy. Methods: SW872, LiSa-2, and FU-DDLS-1 liposarcoma, and control 293 embryonic kidney and HT1080 fibrosarcoma cell lines were treated with HIV PIs and subjected to cellular and molecula

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Chen, S., D. O. Henry, and M. K. Wong. "The biologic therapy of prostate cancer using plasminogen activator inhibitor-1 (PAI-1)." Journal of Clinical Oncology 24, no. 18_suppl (2006): 14596. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.14596.

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14596 Background: Treating prostate cancer through the expression of intrinsic biologic modifiers is a relatively unexplored aspect of prostate cancer therapy. Plasminogen Activator Inhibitor-1 (PAI-1) is expressed at low levels in prostate cancer cells. PAI-1 is both an anti-angiogenesis agent, and also potently inhibits tumor proteases responsible for tumor invasion and metastases such as uPA and tPA. Thus we hypothesized that stimulation of tumor endogenous PAI-1 would result in a particularly powerful and profound prostate cancer regression. We present proof-of-concept from our experimenta

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Borissenko, Ljudmila, and Michael Groll. "Corrigendum to “Crystal Structure of TET Protease Reveals Complementary Protein Degradation Pathways in Prokaryotes” [J. Mol. Biol. (2005) 346, 1207–1219]." Journal of Molecular Biology 351, no. 1 (2005): 247. http://dx.doi.org/10.1016/j.jmb.2005.03.032.

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7

Byarugaba, Denis K., Godfrey Wokorach, Stephen Alafi, et al. "Whole Genome Sequencing Reveals High Genetic Diversity, Diverse Repertoire of Virulence-Associated Genes and Limited Antibiotic Resistance Genes among Commensal Escherichia coli from Food Animals in Uganda." Microorganisms 11, no. 8 (2023): 1868. http://dx.doi.org/10.3390/microorganisms11081868.

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Commensal Escherichia coli with broad repertoire of virulence and antimicrobial resistance (AMR) genes pose serious public health risks as reservoirs of AMR and virulence. This study undertook whole genome characterization of commensal E. coli from food-producing animals in Uganda to investigate their genome variability (resistome and virulome). We established that the E. coli had high genomic diversity with 38 sequence types, 24 FimH types, and 33 O-antigen serotypes randomly distributed within three phylogroups (A, B1, and E). A greater proportion (≥93.65%) of the E. coli were resistant to a

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8

Maghsoudi, Nader, Narges Kh Tafreshi, Fariba Khodagholi, et al. "Targeting enteroviral 2A protease by a 16-mer synthetic peptide: Inhibition of 2Apro-induced apoptosis in a stable Tet-on HeLa cell line." Virology 399, no. 1 (2010): 39–45. http://dx.doi.org/10.1016/j.virol.2009.12.017.

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9

Aprikyan, Andrew A. G., Tomas Vaisar, Vahagn Makaryan, and Jay Heinecke. "Cellular Model of Severe Congenital Neutropenia Reveals the Molecular Mechanism of Mutant Elastase-Mediated Agranulocytosis." Blood 104, no. 11 (2004): 1453. http://dx.doi.org/10.1182/blood.v104.11.1453.1453.

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Abstract Severe congenital neutropenia (SCN) or Kostmann’s syndrome defines an inheritable hematopoietic disorder of an impaired neutrophil production in the bone marrow due to a “maturation arrest” at promyelocytic stage of differentiation in the marrow. SCN patients have recurring severe infections and may evolve to develop leukemia. We reported accelerated apoptosis and cell cycle arrest of bone marrow-derived myeloid progenitor cells in SCN patients with acquired, autosomal dominant, as well as autosomal recessive inheritance. We also reported that approximately 80% of these patients have

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10

Aprikyan, Andrew A., Tomas Vaisar, Vahagn Makaryan, and Jay Heinecke. "A Model of Severe Congenital Neutropenia Reveals Signaling Pathways Mediating Mutant Elastase-Triggered Agranulocytosis." Blood 106, no. 11 (2005): 3070. http://dx.doi.org/10.1182/blood.v106.11.3070.3070.

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Abstract Severe congenital neutropenia (SCN; Kostmann’s syndrome or infantile genetic agranulocytosis) defines an inheritable hematopoietic disorder of impaired neutrophil production due to a “maturation arrest” at the promyelocytic stage of differentiation in the bone marrow. SCN patients have recurring severe infections and often develop acute myelogenous leukemia. We and others reported accelerated apoptosis and cell cycle arrest of bone marrow-derived myeloid progenitor cells in SCN patients with autosomal dominant and autosomal recessive inheritance. Heterozygous mutations in the neutroph

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Aprikyan, Andrew A., Vahagn Makaryan, Maxim Totrov, Ruben Abagyan, and David C. Dale. "Small Molecule Inhibitor of Neutrophil Elastase Normalizes Myeloid Differentiation and Improves Impaired Cell Survival Triggered by Elastase Mutations In Patients with Severe Congenital Neutropenia and Acute Myeloid Leukemia." Blood 116, no. 21 (2010): 386. http://dx.doi.org/10.1182/blood.v116.21.386.386.

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Abstract Abstract 386 Heterozygous mutations in the neutrophil elastase gene ELANE have been identified as the primary cause of severe congenital neutropenia (SCN) associated with recurring severe infections and evolution to acute myeloid leukemia (AML). As of today, more than 50 substitution, truncation, insertion and deletion mutations have been identified. Animal studies based on knock-in or knockout of ELANE in mice failed to produce severe neutropenia phenotype. We and others previously reported that expression of various mutants but not wild type neutrophil elastase (NE) in human but not

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12

Wen, Wenjun, Shijie Li, and Junping Wang. "The Effects of Tea Polyphenol on Chicken Protein Digestion and the Mechanism under Thermal Processing." Foods 12, no. 15 (2023): 2905. http://dx.doi.org/10.3390/foods12152905.

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Meat product is the main food and major source of daily protein intake. Polyphenols are always introduced into many meat products during processing. Some complex interactions may occur between polyphenol and meat protein during the processing, especially thermal processing, which may affect the digestion of protein. In this experiment, chicken protein and tea polyphenol were interacted in simulated systems to explore the effects of the interaction between meat protein and polyphenols on the digestion of meat protein. The mechanism of tea polyphenol inhibiting chicken protein digestion was stud

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13

Arias, Éliana, Haiming Li, and Rolf Morosoli. "Effect of protease mutations on the production of xylanases in Streptomyces lividans." Canadian Journal of Microbiology 53, no. 6 (2007): 695–701. http://dx.doi.org/10.1139/w07-024.

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Three protease mutants — 7 (tap–), 12 (tap–, ssp–), and 17 (multiple mutations) — of Streptomyces lividans were tested for their influence on protein secretion. Streptomyces lividans grown in xylan secretes 3 xylanases (A, B, and C). Xylanases A (XlnA) and B (XlnB) are secreted by the Sec pathway, whereas xylanase C (XlnC) is secreted by the Tat pathway. The production of XlnA and XlnC was affected in the mutants, suggesting that the mutations interfered with both Sec- and Tat-secretion systems. However, the processing rate for the Sec and Tat precursor was similar to the wild-type strain, ind

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Camerer, Eric, Ivo Cornelissen, Hiroshi Kataoka, Daniel N. Duong, Yao-Wu Zheng, and Shaun R. Coughlin. "Roles of protease-activated receptors in a mouse model of endotoxemia." Blood 107, no. 10 (2006): 3912–21. http://dx.doi.org/10.1182/blood-2005-08-3130.

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Endotoxemia is often associated with extreme inflammatory responses and disseminated intravascular coagulation. Protease-activated receptors (PARs) mediate cellular responses to coagulation proteases, including platelet activation and endothelial cell reactions predicted to promote inflammation. These observations suggested that PAR activation by coagulation proteases generated in the setting of endotoxemia might promote platelet activation, leukocyte-mediated endothelial injury, tissue damage, and death. Toward testing these hypotheses, we examined the effect of PAR deficiencies that ablate p

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15

Polster, Brian M., Karla A. Mark, Rafael Arze, and Derek Hudson. "Calpain-Independent Intracellular Protease Activity Is Elevated in Excitotoxic Cortical Neurons Prior to Delayed Calcium Deregulation and Mitochondrial Dysfunction." Biomolecules 12, no. 7 (2022): 1004. http://dx.doi.org/10.3390/biom12071004.

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Glutamate excitotoxicity contributes to many neurodegenerative diseases. Excessive glutamate receptor-mediated calcium entry causes delayed calcium deregulation (DCD) that coincides with abrupt mitochondrial depolarization. We developed cA-TAT, a live-cell protease activity reporter based on a vimentin calpain cleavage site, to test whether glutamate increases protease activity in neuronal cell bodies prior to DCD. Treatment of rat cortical neurons with excitotoxic (100 µM) glutamate increased the low baseline rate of intracellular cA-TAT proteolysis by approximately three-fold prior to DCD an

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16

Aprikyan, Andrew A., Vahagn Makaryan, Maxim Totrov, Ruben Abagyan, and David C. Dale. "Small Molecule Inhibitor of Neutrophil Elastase and Severe Congenital Neutropenia." Blood 114, no. 22 (2009): 552. http://dx.doi.org/10.1182/blood.v114.22.552.552.

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Abstract Abstract 552 Severe congenital neutropenia (SCN) is a rare heritable hematopoietic disorder characterized by maturation arrest at the promyelocytes, recurring severe infections, and evolution to leukemia. Heterozygous mutations in the neutrophil elastase (NE or ELANE) gene (sporadic or autosomal-dominant SCN) or homozygous mutations in the HAX1 gene (autosomal-recessive SCN) are associated with similar clinical phenotype and a block of myeloid differentiation or “maturation arrest” in the marrow. We and others reported that human myeloid progenitor cells expressing mutant elastase exh

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17

Park, Junsoo, Rackhyun Park, Minsu Jang, and Yea-In Park. "Therapeutic Potential of EGCG, a Green Tea Polyphenol, for Treatment of Coronavirus Diseases." Life 11, no. 3 (2021): 197. http://dx.doi.org/10.3390/life11030197.

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Epigallocatechin gallate (EGCG) is a major catechin found in green tea, and there is mounting evidence that EGCG is potentially useful for the treatment of coronavirus diseases, including coronavirus disease 2019 (COVID-19). Coronaviruses encode polyproteins that are cleaved by 3CL protease (the main protease) for maturation. Therefore, 3CL protease is regarded as the main target of antivirals against coronaviruses. EGCG is a major constituent of brewed green tea, and several studies have reported that EGCG inhibits the enzymatic activity of the coronavirus 3CL protease. Moreover, EGCG has bee

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Aprikyan, Andrew A., Vahagn Makaryan, Qian Si, et al. "Small Molecule Inhibitor of Neutrophil Elastase Restores Impaired Production of Human Myeloid Cells Observed in Severe Congenital Neutropenia." Blood 110, no. 11 (2007): 664. http://dx.doi.org/10.1182/blood.v110.11.664.664.

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Abstract Severe congenital neutropenia (SCN) is a rare hematopoietic disease characterized by maturation arrest at the promyelocytes, recurring severe infections, and evolution to leukemia. Heterozygous mutations in either the neutrophil elastase (NE, ELA2) gene (sporadic or autosomal-dominant SCN) or homozygous mutations in the HAX1 gene (autosomal-recessive SCN) are associated with a similar clinical phenotype and similar block of myeloid differentiation in the marrow. Most studies now indicate that the maturation arrest in SCN is due to accelerated apoptosis of myeloid progenitors triggered

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19

Yano, Kazuo, Toshiharu Ito, Hiroki Shigematus, et al. "Purification of Proplatelet Formation (PPF) Stimulating Factor: Thrombin/Antithrombin III Complex Stimulates PPF of Megakaryocytes In Vitro and Platelet Production In Vivo." Thrombosis and Haemostasis 85, no. 02 (2001): 349–55. http://dx.doi.org/10.1055/s-0037-1615691.

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SummaryIn this study, the protein which stimulates proplatelet formation (PPF) of megakaryocytes was purified from normal human plasma using 7 steps procedures. Two different protease inhibitors were identified based on their amino acid sequences, i.e. antithrombin III (AT III) and C1 inhibitor. They were included in high density lipoprotein (HDL). HDL was necessary for AT III to be active in PPF in vitro. The biological effects of the AT III /HDL or thrombin-AT III (TAT)/HDL were studied in vitro. PPF of murine megakaryocytes was stimulated by negative control (BSA) (1.8 ± 0.3%), AT III (2.0

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Nag, Jeetendra, and Rachel Bar-Shavit. "Transcriptional Landscape of PARs in Epithelial Malignancies." International Journal of Molecular Sciences 19, no. 11 (2018): 3451. http://dx.doi.org/10.3390/ijms19113451.

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G protein-coupled receptors (GPCRs), the largest family of cell receptors, act as important regulators of diverse signaling pathways. Our understanding of the impact of GPCRs in tumors is emerging, yet there is no therapeutic platform based on GPCR driver genes. As cancer progresses, it disrupts normal epithelial organization and maintains the cells outside their normal niche. The dynamic and flexible microenvironment of a tumor contains both soluble and matrix-immobilized proteases that contribute to the process of cancer advancement. An example is the activation of cell surface protease-acti

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Storozhuk, Maksim, Siyun Lee, Jin I. Lee, and Junsoo Park. "Green Tea Consumption and the COVID-19 Omicron Pandemic Era: Pharmacology and Epidemiology." Life 13, no. 3 (2023): 852. http://dx.doi.org/10.3390/life13030852.

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In spite of the development of numerous vaccines for the prevention of COVID-19 and the approval of several drugs for its treatment, there is still a great need for effective and inexpensive therapies against this disease. Previously, we showed that green tea and tea catechins interfere with coronavirus replication as well as coronavirus 3CL protease activity, and also showed lower COVID-19 morbidity and mortality in countries with higher green tea consumption. However, it is not clear whether green tea is still effective against the newer SARS-CoV-2 variants including omicron. It is also not

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Eljaaly, Khalid, Hani Asfour, Tarek Ibrahim, et al. "503. In vitro Evaluation of Sitagliptin-HIV-1 Trans-activator Transcription Peptide Nano-formula for Antiviral Activity Against SARS-CoV-2: Drug Repurposing Approach." Open Forum Infectious Diseases 8, Supplement_1 (2021): S354. http://dx.doi.org/10.1093/ofid/ofab466.702.

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Abstract Background The outbreak of COVID-19 pandemic in China regarded as a major health/economic hazard. The importance of coming up with mechanisms for preventing or treating COVID-19 has been felt across the world. This work aimed at examining the efficiency of Sitagliptin (SIT) and human immunodeficiency virus type 1 (HIV-1) trans-activator transcription peptide (TAT) against SARS-CoV-2. Methods SIT-TAT nano-conjugates were prepared according to a full three-factor bi-level (23) factorial design. SIT concentration (mM, X1), TAT concentration (mM, X2), and pH (X3) were selected as the fact

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Mayor-Nunez, Diana, Zhanxin Ji, Xiujun Sun, Lucy Teves, J. David Garman, and Michael Tymianski. "Plasmin-resistant PSD-95 inhibitors resolve effect-modifying drug-drug interactions between alteplase and nerinetide in acute stroke." Science Translational Medicine 13, no. 588 (2021): eabb1498. http://dx.doi.org/10.1126/scitranslmed.abb1498.

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Neuroprotection for acute ischemic stroke is achievable with the eicosapeptide nerinetide, an inhibitor of the protein-protein interactions of the synaptic scaffolding protein PSD-95. However, nerinetide is subject to proteolytic cleavage if administered after alteplase, a standard-of-care thrombolytic agent that nullifies nerinetide’s beneficial effects. Here, we showed, on the basis of pharmacokinetic data consistent between rats, primates, and humans, that in a rat model of embolic middle cerebral artery occlusion (eMCAO), nerinetide maintained its effectiveness when administered before alt

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Kamimura, Y., and K. Hayano. "Properties of protease extracted from tea-field soil." Biology and Fertility of Soils 30, no. 4 (2000): 351–55. http://dx.doi.org/10.1007/s003740050015.

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25

Chen, Chia-Nan, Coney P. C. Lin, Kuo-Kuei Huang, et al. "Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3'-digallate (TF3)." Evidence-Based Complementary and Alternative Medicine 2, no. 2 (2005): 209–15. http://dx.doi.org/10.1093/ecam/neh081.

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SARS-CoV is the causative agent of severe acute respiratory syndrome (SARS). The virally encoded 3C-like protease (3CLPro) has been presumed critical for the viral replication of SARS-CoV in infected host cells. In this study, we screened a natural product library consisting of 720 compounds for inhibitory activity against 3CLPro. Two compounds in the library were found to be inhibitive: tannic acid (IC50 = 3 µM) and 3-isotheaflavin-3-gallate (TF2B) (IC50 = 7 µM). These two compounds belong to a group of natural polyphenols found in tea. We further investigated the 3CLPro-inhibitory activity o

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Oanh, Doan Thi Yen, Ly Thi Minh Hien, Nguyen Kha Duyen, Nguyen Huu Hieu, and Dong Thi Anh Dao. "Effect of enzyme – assisted extraction on total polyphenol content and antioxidant capacity from fresh tea leaves (Camellia sinensis)." Vietnam Journal of Chemistry 61, no. 5 (2023): 551–62. http://dx.doi.org/10.1002/vjch.202300109.

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AbstractTea leaves contain high concentration of polyphenols, known as bioactive compounds. In order to increase the extraction yield of polyphenol and the antioxidant capacity of the extract from tea leaves, the combination of cellulase, pectinase and protease in enzyme‐assisted extraction was investigated. By using fractional factorial experimental design to study the two‐enzyme assisted extraction of cellulase and pectinase, three factors including solvent/material ratio, pH and hydrolysis time showed significant effects on the extract properties. The highest total polyphenol content obtain

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27

Lafrenie, R. M., L. M. Wahl, J. S. Epstein, I. K. Hewlett, K. M. Yamada, and S. Dhawan. "HIV-1-Tat modulates the function of monocytes and alters their interactions with microvessel endothelial cells. A mechanism of HIV pathogenesis." Journal of Immunology 156, no. 4 (1996): 1638–45. http://dx.doi.org/10.4049/jimmunol.156.4.1638.

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Abstract Monocytes are major targets of HIV infection in patients with AIDS. In vitro infection of monocytes with HIV is associated with increased expression of beta 2 integrins, which increases both monocyte aggregation and monocyte/endothelial adhesion as well as monocyte metalloproteinase (MMP-9) expression. Treatment of primary monocytes with soluble HIV-Tat protein mimicked many of the properties of HIV infection of monocytes. Tat treatment up-regulated the expression of the beta 2 integrins, which was associated with the formation of large aggregates of monocytes and increased adhesion t

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T, Indhumathi. "Isolation of Alkaline Protease from Fruit Waste and its Application as Detergent." Bioscience Biotechnology Research Communications 16, no. 3 (2023): 190–96. http://dx.doi.org/10.21786/bbrc/16.3.9.

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The modernization of the society has made our environment face a series of changes. One among them is the enzymatic method produced by microorganisms from any waste. Considering the fruit waste globally several industrial uses have been fulfilled by the fruit waste. The most abundant enzyme now a days is protease from papaya waste isolated from Bacillus spp. Alkaline protease has been choosen for the detergent industries widely since it has pH range over 7.5. It performs more effectively in decomposing proteins. Since, it is stable over wide temperature and pH range. The aim of the study was t

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Apolloni, Ann, C. William Hooker, Johnson Mak, and David Harrich. "Human Immunodeficiency Virus Type 1 Protease Regulation of Tat Activity Is Essential for Efficient Reverse Transcription and Replication." Journal of Virology 77, no. 18 (2003): 9912–21. http://dx.doi.org/10.1128/jvi.77.18.9912-9921.2003.

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ABSTRACT The human immunodeficiency virus type 1 (HIV-1) Tat protein enhances reverse transcription, but it is not known whether Tat acts directly on the reverse transcription complex or through indirect mechanisms. Since processing of Tat by HIV protease (PR) might mask its presence and, at least in part, explain this lack of data, we asked whether Tat can be cleaved by PR. We used a rabbit reticulocyte lysate (RRL) system to make Tat and PR. HIV-1 PR is expressed as a Gag-Pol fusion protein, and a PR-inactivated Gag-Pol is also expressed as a control. We showed that Tat is specifically cleav

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Gallo, Navarro, Franco, and Andreu. "A2A Receptor Homodimer-Disrupting Sequence Efficiently Delivered by a Protease-Resistant, Cyclic CPP Vector." International Journal of Molecular Sciences 20, no. 19 (2019): 4937. http://dx.doi.org/10.3390/ijms20194937.

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G-protein-coupled receptors associate into dimers/oligomers whose function is not well understood. One approach to investigate this issue is to challenge oligomerization by peptides replicating transmembrane domains and to study their effect on receptor functionality. The disruptor peptides are typically delivered by means of cell-penetrating vectors such as the human immunodeficiency virus (HIV) transcription trans-activation protein Tat. In this paper we report a cyclic, Tat-like peptide that significantly improves its linear analogue in targeting interreceptor sequences in the transmembrane

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Trubiani, O., S. Guarnieri, R. Paganelli, and R. di Primio. "Involvement of Caspase-3 in the Cleavage of Terminal Transferase." International Journal of Immunopathology and Pharmacology 15, no. 3 (2002): 201–8. http://dx.doi.org/10.1177/039463200201500306.

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To investigate the in vivo role of caspase-3 in Terminal Transferase metabolism DMSO-treated RPMI-8402, a human pre-T cell line was used. In DMSO treated samples 3H-dGTP incorporation and TdT phosphorylation occurs after 4 hours of treatment. After 8 hours cells undergo TdT proteolysis in addition to its inactivation. The cleavage of TdT into 32- and 58-KDa proteolytic fragments occurred simultaneously with the activation of Caspase-3, but preceded changes associated with the apoptotic process described after 48 hours of treatment. The Caspase-3 peptide inhibitor V, used as a specific inhibito

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Jang, Minsu, Yea-In Park, Yeo-Eun Cha, et al. "Tea Polyphenols EGCG and Theaflavin Inhibit the Activity of SARS-CoV-2 3CL-Protease In Vitro." Evidence-Based Complementary and Alternative Medicine 2020 (September 17, 2020): 1–7. http://dx.doi.org/10.1155/2020/5630838.

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COVID-19, a global pandemic, has caused over 750,000 deaths worldwide as of August 2020. A vaccine or remedy for SARS-CoV-2, the virus responsible for COVID-19, is necessary to slow down the spread and lethality of COVID-19. However, there is currently no effective treatment available against SARS-CoV-2. In this report, we demonstrated that EGCG and theaflavin, the main active ingredients of green tea and black tea, respectively, are potentially effective to inhibit SARS-CoV-2 activity. Coronaviruses require the 3CL-protease for the cleavage of its polyprotein to make individual proteins funct

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Osmulski, Paweł A., Przemysław Karpowicz, Elżbieta Jankowska, Jonathan Bohmann, Andrew M. Pickering, and Maria Gaczyńska. "New Peptide-Based Pharmacophore Activates 20S Proteasome." Molecules 25, no. 6 (2020): 1439. http://dx.doi.org/10.3390/molecules25061439.

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The proteasome is a pivotal element of controlled proteolysis, responsible for the catabolic arm of proteostasis. By inducing apoptosis, small molecule inhibitors of proteasome peptidolytic activities are successfully utilized in treatment of blood cancers. However, the clinical potential of proteasome activation remains relatively unexplored. In this work, we introduce short TAT peptides derived from HIV-1 Tat protein and modified with synthetic turn-stabilizing residues as proteasome agonists. Molecular docking and biochemical studies point to the α1/α2 pocket of the core proteasome α ring a

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Mani, Santhosh K., Sundaravadivel Balasubramanian, Juozas A. Zavadzkas, et al. "Calpain inhibition preserves myocardial structure and function following myocardial infarction." American Journal of Physiology-Heart and Circulatory Physiology 297, no. 5 (2009): H1744—H1751. http://dx.doi.org/10.1152/ajpheart.00338.2009.

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Cardiac pathology, such as myocardial infarction (MI), activates intracellular proteases that often trigger programmed cell death and contribute to maladaptive changes in myocardial structure and function. To test whether inhibition of calpain, a Ca2+-dependent cysteine protease, would prevent these changes, we used a mouse MI model. Calpeptin, an aldehydic inhibitor of calpain, was intravenously administered at 0.5 mg/kg body wt before MI induction and then at the same dose subcutaneously once per day. Both calpeptin-treated ( n = 6) and untreated ( n = 6) MI mice were used to study changes i

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Posma, Jens, Rene van Oerle, Diane Fens, et al. "Interrogation of the Coagulation Cascade Acute Coronary Syndrome Using Novel Elisa-Based Assays for Single Protease Quantification." Blood 132, Supplement 1 (2018): 5013. http://dx.doi.org/10.1182/blood-2018-99-118353.

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Abstract Background: Acute coronary syndrome (ACS), the main contributor to myocardial infarction, is a thrombotic complication of atherosclerosis. Growing evidence supports a role for the intrinsic coagulation cascade in various thrombotic diseases. To gain more inside in the contribution of the intrinsic coagulation cascade in an ACS, we developed novel, ELISA-based assays for the quantification of Kallikrein, activated factor XII (FXIIa), FXIa, FXa, FIXa, and thrombin in complex with a physiological inhibitor. Methods: During this prospective cohort study, blood from patients with a first A

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Dubiel, Wolfgang, Katherine Ferrell, and Martin Rechsteiner. "Tat-Bindung Protein 7 is a Subunit of the 26S Protease." Biological Chemistry Hoppe-Seyler 375, no. 4 (1994): 237–40. http://dx.doi.org/10.1515/bchm3.1994.375.4.237.

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Coronado, Mônika A., Ian Gering, Marc Sevenich, et al. "The Importance of Epigallocatechin as a Scaffold for Drug Development against Flaviviruses." Pharmaceutics 15, no. 3 (2023): 803. http://dx.doi.org/10.3390/pharmaceutics15030803.

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Arboviruses such as Dengue, yellow fever, West Nile, and Zika are flaviviruses vector-borne RNA viruses transmitted biologically among vertebrate hosts by blood-taking vectors. Many flaviviruses are associated with neurological, viscerotropic, and hemorrhagic diseases, posing significant health and socioeconomic concerns as they adapt to new environments. Licensed drugs against them are currently unavailable, so searching for effective antiviral molecules is still necessary. Epigallocatechin molecules, a green tea polyphenol, have shown great virucidal potential against flaviviruses, including

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Suzuka, Iwao, Yasunori Koga-Ban, Takuji Sasaki, Yuzo Minobe, and Junji Hashimoto. "Identification of cDNA clones for rice homologs of the human immunodeficiency virus-1 Tat binding protein and subunit 4 of human 26S protease (proteasome)." Plant Science 103, no. 1 (1994): 33–40. http://dx.doi.org/10.1016/0168-9452(94)03986-0.

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Assiry, Ali A., Shaeesta Khaleelahmed Bhavikatti, Fahad A. Althobaiti, Roshan Noor Mohamed, and Mohmed Isaqali Karobari. "Evaluation of In Vitro Antiprotease Activity of Selected Traditional Medicinal Herbs in Dentistry and Its In Silico PASS Prediction." BioMed Research International 2022 (June 6, 2022): 1–8. http://dx.doi.org/10.1155/2022/5870443.

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Background. Dental/oral diseases are one of the significant public health problems globally. Herbal medicines for managing oral diseases are considered an effective alternative to synthetic compounds due to their lower side effect. Azadirachta indica, Terminalia chebula, Camellia sinensis, and Piper nigrum are used to control and prevent oral inflammations in dentistry. In this study, we have evaluated the protease inhibition activity of these plant extracts, and further, the binding mode of the active ingredient of these plants with trypsin was studied using molecular docking. Methods. In thi

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Ye, Jianghua, Qi Zhang, Miao Jia, et al. "The Effects of Rock Zones and Tea Tree Varieties on the Growth and Quality of Wuyi Rock Tea Based on the OPLS-DA Model and Machine Learning." Agriculture 14, no. 4 (2024): 573. http://dx.doi.org/10.3390/agriculture14040573.

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Rock zones have an important influence on the yield and quality of Wuyi rock tea. In this study, OPLS-DA combined with machine learning was used to analyze the effects of different rock zones and tea tree varieties on the physicochemical properties of rhizosphere soil, the growth of the tea tree and the quality of the tea leaves using tea trees in different rock zones. The results showed that rock zones had significant effects on rhizosphere soil physicochemical indexes, soil enzyme activities, tea tree growth and tea quality indexes, while there was little difference between different tea tre

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Patel, Ashish, Alkesh Patel, Rahul Hemani, et al. "Exploring the in-silico approach for assessing the potential of natural compounds as a SARS-CoV-2 main protease inhibitors." Organic Communications 14, no. 1 (2021): 58–72. http://dx.doi.org/10.25135/acg.oc.97.2012.1895.

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The SARS-CoV-2 virus emerged as a major cause of the COVID-19 pandemic in December 2019. Many attempts have been made to block the viral infection by targeting various processes like its entry, uncoating, replication, activating T cells response, and rising antibody titer. Also, many drugs are repurposed like remdesivir, dexamethasone, tocilizumab, hydroxychloroquine based on their established therapeutic efficacy against other viruses in the past. Natural products (NP) consist of a promising candidate and are needed to evaluate those molecules with molecular docking for preliminary screening

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Hamzah, Haidar Ali, Junoretta Haviva Ernanto, Putri Mahirah Afladhanti, and Theodorus Theodorus. "POTENSI DAUN TEH HIJAU (Camellia sinensis) SEBAGAI INHIBITOR MAIN PROTEASE (Mpro) COVID-19: SEBUAH STUDI MOLECULAR DOCKING." Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 7, no. 2 (2022): 212–22. http://dx.doi.org/10.36387/jiis.v7i2.789.

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Green tea is an herbal plant that has active compounds including anti-inflammatory, antioxidant, anti-allergic, and antiviral compounds. A previous study, flavonoid compound in tea leaves has been proven as antiviral. The development of effective antiviral drugs against COVID-19 remains a challenge for researchers across the world. A previous study investigated the role of the main protease enzyme (Mpro) which is useful in the viral life cycle as a promising drug target. This study aims to know the potential compounds of green tea leaves as a COVID-19 Mpro inhibitor using molecular docking. 12

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Khusniati, Tatik. "PRESERVATION OF MILKS WITH ADDITION OF ANTIBACTERIAL AND AROMATIC SUPPLEMENTS PRODUCED IN JAPAN." ASEAN Journal on Science and Technology for Development 25, no. 1 (2017): 1–13. http://dx.doi.org/10.29037/ajstd.225.

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The good antibacterial and aromatic supplements produced in Japan for preservation of milks at storage was investigated. Nineteen sweet and herb materials were made juices as supplements to preserve the milks. Bacterial counts, pH, protease activities and lipase activities of supplemented milks, and antibacterial activities of supplements were detected by total plate counts, glass electrode pH meter, azocasein, modified Dole extraction and turbidity methods. Eleven of nineteen milks added 10% of honey, garlic, ginger, horseradish, “sansho”, “yuzu”, green perilla, “nira”, green tea, bamboo leaf

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Steemson, John D., Nicole J. Moreland, Deborah Williamson, Julie Morgan, Philip E. Carter, and Thomas Proft. "Survey of the bp/tee genes from clinical group A streptococcus isolates in New Zealand – implications for vaccine development." Journal of Medical Microbiology 63, no. 12 (2014): 1670–78. http://dx.doi.org/10.1099/jmm.0.080804-0.

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Group A streptococcus (GAS) is responsible for a wide range of diseases ranging from superficial infections, such as pharyngitis and impetigo, to life-threatening diseases, such as toxic shock syndrome and acute rheumatic fever (ARF). GAS pili are hair-like extensions protruding from the cell surface and consist of highly immunogenic structural proteins: the backbone pilin (BP) and one or two accessory pilins (AP1 and AP2). The protease-resistant BP builds the pilus shaft and has been recognized as the T-antigen, which forms the basis of a major serological typing scheme that is often used as

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Yao, Junting, Weining Yin, Yuqing Chen, et al. "Conjugation of a Cationic Cell-Penetrating Peptide with a Novel Kunitzin-like Trypsin Inhibitor: New Insights for Enhancement of Peptide Bioactivities." Pharmaceutics 14, no. 9 (2022): 1805. http://dx.doi.org/10.3390/pharmaceutics14091805.

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Cationic cell-penetrating peptides (CPPs), such as transactivator of transcription (TAT) peptide, have been proposed as effective drug carriers to improve intracellular delivery of biological macromolecules. Amphibian skin-derived Kunitz-type trypsin inhibitors (KTIs), short counterparts of KTIs from plant sources, were found to possess potent serine protease inhibitory activity. However, poor transmembrane permeability of these molecules has largely hindered the study of the full spectrum of their biological actions. As a result, this study aimed to extend the biological activities of amphibi

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Friesen, P. D., and M. S. Nissen. "Gene organization and transcription of TED, a lepidopteran retrotransposon integrated within the baculovirus genome." Molecular and Cellular Biology 10, no. 6 (1990): 3067–77. http://dx.doi.org/10.1128/mcb.10.6.3067-3077.1990.

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A single copy of the retrotransposon TED, from the moth Trichoplusia ni (a lepidopteran noctuid), was identified within the DNA genome of the baculovirus Autographa californica nuclear polyhedrosis virus. Determination of the complete nucleotide sequence (7,510 base pairs) of the integrated copy indicated that TED belongs to the family of retrotransposons that includes Drosophila melanogaster elements 17.6 and gypsy and thus represents the first nondipteran member of this invertebrate group to be identified. The internal portion of TED, flanked by long terminal repeats (LTRs), is composed of t

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Friesen, P. D., and M. S. Nissen. "Gene organization and transcription of TED, a lepidopteran retrotransposon integrated within the baculovirus genome." Molecular and Cellular Biology 10, no. 6 (1990): 3067–77. http://dx.doi.org/10.1128/mcb.10.6.3067.

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A single copy of the retrotransposon TED, from the moth Trichoplusia ni (a lepidopteran noctuid), was identified within the DNA genome of the baculovirus Autographa californica nuclear polyhedrosis virus. Determination of the complete nucleotide sequence (7,510 base pairs) of the integrated copy indicated that TED belongs to the family of retrotransposons that includes Drosophila melanogaster elements 17.6 and gypsy and thus represents the first nondipteran member of this invertebrate group to be identified. The internal portion of TED, flanked by long terminal repeats (LTRs), is composed of t

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Farooq, Taimoor Hassan, Uttam Kumar, Jing Mo, et al. "Intercropping of Peanut–Tea Enhances Soil Enzymatic Activity and Soil Nutrient Status at Different Soil Profiles in Subtropical Southern China." Plants 10, no. 5 (2021): 881. http://dx.doi.org/10.3390/plants10050881.

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Intercropping is one of the most widely used agroforestry techniques, reducing the harmful impacts of external inputs such as fertilizers. It also controls soil erosion, increases soil nutrients availability, and reduces weed growth. In this study, the intercropping of peanut (Arachishypogaea L.) was done with tea plants (Camellia oleifera), and it was compared with the mono-cropping of tea and peanut. Soil health and fertility were examined by analyzing the variability in soil enzymatic activity and soil nutrients availability at different soil depths (0–10 cm, 10–20 cm, 20–30 cm, and 30–40 c

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Chen, Yiyong, Xiumin Fu, Xin Mei, et al. "Characterization of functional proteases from flowers of tea ( Camellia sinensis ) plants." Journal of Functional Foods 25 (August 2016): 149–59. http://dx.doi.org/10.1016/j.jff.2016.05.017.

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Yang, H., K. Landis-Piwowar, T. H. Chan, and Q. P. Dou. "Green Tea Polyphenols as Proteasome Inhibitors: Implication in Chemoprevention." Current Cancer Drug Targets 11, no. 3 (2011): 296–306. http://dx.doi.org/10.2174/156800911794519743.

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