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Andriyanto, Aryani Sismin Satyaningtijas, Raden Yufiandri, Regina Wulandari, Vinda Mulyetti Darwin, and Santa Nova A. Siburi. "Performa dan Kecernaan Pakan Ayam Broiler yang diberi Hormon Testosteron dengan Dosis Bertingkat." Acta VETERINARIA Indonesiana 3, no. 1 (February 16, 2016): 29–37. http://dx.doi.org/10.29244/avi.3.1.29-37.
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Testosteron merupakan salah satu hormon anabolik yang dapat memacu pertumbuhan massa otot dan tulang. Hormon testosteron mampu merangsang sekresi growth hormone yang berperan dalam pertumbuhan. Penelitian ini bertujuan untuk mempelajari pengaruh pemberian hormon testosteron dengan dosis bertingkat terhadap performa dan kecernaan pakan ayam broiler. Sebanyak 44 ekor ayam broiler berumur 15 hari dengan rata-rata bobot badan antara 650 ± 71 g dibagi menjadi 4 kelompok (K, T1, T2, dan T3). K adalah kelompok kontrol; T1, T2, dan T3 adalah kelompok yang diberi testosteron dosis 1, 2, dan 4 mg per ekor. Parameter yang diukur adalah bobot badan, konsumsi pakan, rasio konversi pakan, serta persentase kandungan nutrisi (di dalam pakan dan feses). Hasil penelitian menunjukkan pemberian testosteron dosis 1 dan 4 mg dapat meningkatkan pertambahan bobot badan harian secara signifikan (p<0,05) pada ayam broiler yang berumur antara 15 dan 18 hari. Testosteron dosis 2 mg meningkatkan bobot badan harian secara signifikan (p<0,05) pada ayam broiler yang berumur antara 21 dan 24 hari. Konsumsi pakan, rasio konversi pakan, dan kecernaan pakan ayam broiler yang diberi hormon testosteron tidak menunjukkan perbedaan dibanding dengan kontrol. Akan tetapi, pada kelompok yang diberi testosteron dosis 4 mg, nilai kecernaan lemak, protein, dan karbohidrat cenderung meningkat.Kata kunci: broiler, kecernaan, pertambahan bobot badan harian, proksimat, testosteron (Broiler Chickens Performance and Feed Digestibility Treated with Multi-Dose Testosterone Hormone)Testosterone is one of the anabolic hormone that can trigger the growth of muscle mass and bone. Testosterone hormone can stimulate secretion of growth hormone that has a role in growth. The aim of this research was to observe the administration of multi-dose testosterone hormone on broiler chickens performance and feed digestibility. Fourty four broiler chickens 15 days old with average weight 650 ± 71 g were divided into 4 groups (K, T1, T2, and T3). K was control group; T1, T2, and T3 were groups which given testosterone dose 1, 2, and 4 mg each chicken. Parameters measured were body weight, feed consumption, feed conversion ratio (FCR), and nutritions percentage (in feed and feces). The results showed that testosterone dose 1 and 4 mg could increase the daily body weight gain significantly (p<0.05) in broiler chickens aged between 15 and 18 days old. Testosterone dose 2 mg could increase the daily body weight gain significantly (p<0.05) in broiler chickens aged between 21 and 24 days old. Feed consumption, FCR, and feed digestibility of chickens given testosterone did not show any difference compare with control. However, in group which given testosterone dose 4 mg, the digestibility values of fat, protein, and carbohydrates tended to increase.Keywords: broiler, digestibility, daily body weight gain, proximate, testosterone
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Qadarsina, Qadarsina, Dasrul Dasrul, and Sri Wahyuni. "Konsentrasi Hormon Testosteron Kerbau Simeulue dan Korelasinya dengan Tingkat Umur dan Lingkar Skrotum." Jurnal Agripet 19, no. 1 (April 1, 2019): 13–21. http://dx.doi.org/10.17969/agripet.v19i1.8692.
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ABSTRAK. Penelitian ini bertujuan mengetahui konsentrasi hormon testosteron kerbau Simeulue dan korelasinya dengan tingkat umur dan lingkar skrotum. Sebanyak 15 ekor kerbau Simeulue jantan dibagi dalam tiga kelompok yaitu umur 2,1-3,0 tahun; 3,1-4,0 tahun, dan 4,1-5,0 tahun. Parameter yang diamati terdiri dari lingkar skrotum dan konsentrasi hormon testosteron. Data yang diperoleh dianalisis dengan analisis varian satu arah dan selanjutnya diuji dengan uji berganda Duncan. Untuk mengetahui hubungan antara umur, lingkar skrotum dengan konsentrasi hormon testosteron digunakan analisis regresi sederhana. Hasil analisis pada lingkar skrotum dan konsentrasi hormon testosteron memperlihatkan perbedaan yang nyata (P0,05). Lingkar skrotum dan kadar testosteron serum umur 2,1- 3,0 tahun berbeda secara nyata (P0,05) dengan umur 3,1- 4,0 tahun dan 4,1 - 5,0 tahun. Terdapat hubungan yang nyata (P0,05) antara konsentrasi hormon testosteron dengan umur dan lingkar skrotum, dengan persamaan regresi Y = -4,925-0,436 X1 + 0,697 X2. dengan nilai koefesien korelasi (r) sebesar 0,675 dan koefisien determinasi (r2) sebesar 0,455. Hasil ini menunjukkan bahwa lingkar skrotum (X2) berpengaruh sebesar 67,10 % terhadap konsentrasi hormon testosteron, lebih tinggi dibanding umur (X1) yang berpengaruh sebesar 46,60%. Kesimpulan, umur berpengaruh terhadap lingkar skrotum dan konsentrasi hormon testosteron kerbau Simeulue. Kerbau Simeulue berumur 4,1 - 5,0 tahun memiliki korelasi yang lebih kuat dari pada kerbau Simeulue umur 2,1 - 3,0 dan 3,1 - 4,0 tahun terhadap lingkar skrotum dan konsentrasi testosteron. (Testosterone hormone concentration of Simeulue buffalo and its correlation with age level and the scrotum circumference) ABSTRACT . The objective of this study was to determine the testosterone hormone concentration of Simeulue buffalo and its correlation with age level and the scrotum circumference. Fifteen male Simeulue buffalo were divided into three groups: 2.1 - 3.0 years; 3.1-4.0 and 4.1-5.0 years where each group consists of five buffaloes. The parameter observed consisted of age, scrotal circumference and testosterone hormone concentration. The data obtained were analyzed by one-way analysis of variance. The difference is tested with Duncan multiple tests. Meanwhile, simple regression analysis was used to testing the relationship between age and scrotal circumference with testosterone hormone concentration. The results showed that the scrotal circumferences and testosterone hormone concentration have significant differences (P 0.05). Scrotal circumference and testosterone level of 2.1-3.0 years were significantly different (P 0.05) with age 3.1- 4.0 years and 4.1 - 5.0 years. Additionally, there is a relationship (P0,05) between testosterone hormone concentration with age and scrotal circumference, with correlation coefficient value (r) = 0.675 and determination coefficient(r2) = 0,455, with regression equality Y =- 4,925 - 0,436 X1 + 0,697 X2. In conclusion, age affected the scrotal circumference and testosterone hormone concentration in the Simeulue buffalo. 4.1 - 5.0 years Simeulue buffalo has stronger correlation than 2.1 - 3.0 and 3.1 - 4.0 years of Simeulue Buffalo at scrotal circumference and testosterone concentration.
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Bhasin, Shalendar. "How Does Testosterone Augment the Anabolic Response to Exercise in Frail Older Adults?" Innovation in Aging 5, Supplement_1 (December 1, 2021): 295. http://dx.doi.org/10.1093/geroni/igab046.1146.
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Abstract Testosterone treatment increases muscle mass, strength, and leg power in menopausal women, hypogonadal men, older men with mobility limitation, COPD and ESRD. Testosterone's effects on muscle mass and strength are augmented by exercise training and growth hormone. Testosterone treatment improves some measures of physical performance, such as stair climbing power and aerobic capacity; the improvements in gait speed have been modest. Testosterone increases muscle mass by inducing the hypertrophy of type 1 and 2 muscle fibers, and by increasing satellite cell number. Testosterone promotes the differentiation of mesenchymal progenitor cells into myogenic lineage and inhibits their differentiation into adipogenic lineage by activating Wnt-target genes, including follistatin that plays an important role in mediating testosterone's effects on the muscle. Testosterone also increases polyamine synthesis in the muscle. Combined administration of testosterone plus multi-component exercise intervention that includes functional training may be needed to improve function and mobility in older adults.
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Nave, Gideon, Amos Nadler, David Zava, and Colin Camerer. "Single-Dose Testosterone Administration Impairs Cognitive Reflection in Men." Psychological Science 28, no. 10 (August 3, 2017): 1398–407. http://dx.doi.org/10.1177/0956797617709592.
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In nonhumans, the sex steroid testosterone regulates reproductive behaviors such as fighting between males and mating. In humans, correlational studies have linked testosterone with aggression and disorders associated with poor impulse control, but the neuropsychological processes at work are poorly understood. Building on a dual-process framework, we propose a mechanism underlying testosterone’s behavioral effects in humans: reduction in cognitive reflection. In the largest study of behavioral effects of testosterone administration to date, 243 men received either testosterone or placebo and took the Cognitive Reflection Test (CRT), which estimates the capacity to override incorrect intuitive judgments with deliberate correct responses. Testosterone administration reduced CRT scores. The effect remained after we controlled for age, mood, math skills, whether participants believed they had received the placebo or testosterone, and the effects of 14 additional hormones, and it held for each of the CRT questions in isolation. Our findings suggest a mechanism underlying testosterone’s diverse effects on humans’ judgments and decision making and provide novel, clear, and testable predictions.
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Constantino, John N. "Dominance and aggression over the life course: Timing and direction of causal influences." Behavioral and Brain Sciences 21, no. 3 (June 1998): 369. http://dx.doi.org/10.1017/s0140525x9831122x.
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Studies of testosterone's effect on dominance are confounded by the effects of dominance experiences on testosterone. Furthermore, antisocial behavior tends to originate prepubertally, when testosterone levels are the same for aggressive males, nonaggressive males, and females. It seems more parsimonious to view variation in testosterone as an effect of dominance-related mood states than to invoke a reciprocal model.
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Grotzinger, Andrew D., Frank D. Mann, Megan W. Patterson, Jennifer L. Tackett, Elliot M. Tucker-Drob, and K. Paige Harden. "Hair and Salivary Testosterone, Hair Cortisol, and Externalizing Behaviors in Adolescents." Psychological Science 29, no. 5 (February 14, 2018): 688–99. http://dx.doi.org/10.1177/0956797617742981.
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Although testosterone is associated with aggression in the popular imagination, previous research on the links between testosterone and human aggression has been inconsistent. This inconsistency might be because testosterone’s effects on aggression depend on other moderators. In a large adolescent sample ( N = 984, of whom 460 provided hair samples), we examined associations between aggression and salivary testosterone, hair testosterone, and hair cortisol. Callous-unemotional traits, parental monitoring, and peer environment were examined as potential moderators of hormone-behavior associations. Salivary testosterone was not associated with aggression. Hair testosterone significantly predicted increased aggression, particularly at low levels of hair cortisol (i.e., Testosterone × Cortisol interaction). This study is the first to examine the relationship between hair hormones and externalizing behaviors and adds to the growing literature that indicates that androgenic effects on human behavior are contingent on aspects of the broader endocrine environment—in particular, levels of cortisol.
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Linares, Mauricio, José Luis Pruneda-Paz, Luciana Reyna, and Susana Genti-Raimondi. "Regulation of testosterone degradation in Comamonas testosteroni." Journal of Steroid Biochemistry and Molecular Biology 112, no. 1-3 (November 2008): 145–50. http://dx.doi.org/10.1016/j.jsbmb.2008.09.011.
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Fedy, Bradley C., and Bridget J. M. Stutchbury. "Testosterone Does not Increase in Response to Conspecific Challenges in the White-Bellied Antbird (Myrmeciza Longipes), A Resident Tropical Passerine." Auk 123, no. 1 (January 1, 2006): 61–66. http://dx.doi.org/10.1093/auk/123.1.61.
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Abstract Resident tropical passerines that exhibit year-round territorial aggression do not fit well into the temperate-zone model, because testosterone does not increase substantially during the breeding season. We studied patterns of testosterone secretion in the White-bellied Antbird (Myrmeciza longipes), a resident tropical species in Panama that maintains territories year-round and is capable of aggression throughout the year, regardless of its stage of reproduction. Levels of plasma testosterone were low (mean = 0.30 ng mL−1) throughout the breeding and nonbreeding seasons and did not differ between them. Testosterone also did not increase in response to simulated conspecific intrusions. When we used temporary removal experiments to induce natural, extended conflict between males, testosterone levels did not increase in response to the extended social instability that resulted. White-bellied Antbirds demonstrate an apparent uncoupling of testosterone and territorial aggression throughout the year. La Testosterona no Aumenta como Respuesta a Desafíos de Individuos Coespecíficos en Myrmeciza longipes, un Paserino Residente de la Zona Tropical
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Balvočius, Antanas. "Vyrų sutrikusios lytinės funkcijos androgeniniai aspektai." Lietuvos chirurgija 3, no. 4 (January 1, 2005): 0. http://dx.doi.org/10.15388/lietchirur.2005.4.2302.
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Antanas BalvočiusTarptautinis medicinos centras Union Clinic Vilnius,Tilto g. 1/2, VilniusEl paštas: balvociusa@delfi.lt Įvadas / tikslas Lytinių steroidinių hormonų endokrininiai sutrikimai neigiamai paveikia vyrų lytinę funkciją. Straipsnio tikslas – pateikti pagyvenusių vyrų lytinės disfunkcijos tyrimų ir gydymo rezultatus, apžvelgti mokslinę literatūrą apie endokrininę vyrų lytinės disfunkcijos patofiziologiją, diagnostiką ir gydymą. Ligoniai ir metodai Nuo lytinės disfunkcijos gydyti 64 pagyvenę (50–75 metų, vidutinis amžius 59 metai) vyrai. Erekcijos sutrikimai pagal TEFR-5 skalę svyravo nuo 11 iki 21 balo (vidutiniškai 15,5). Testosterono (T) kraujo serume buvo nuo 15,8 iki 4,6 nmol/L. Mažiau kaip 11 nmol/L rasta 44 vyrams (69%). Pavartoję FDE-5 inhibitorių, erekcijos kokybe buvo nepatenkinti iš 64 net 46 ligoniai, iš jų 35 ligoniams buvo taikytas kombinuotasis gydymas: 250 mg testosterono injekcijos į raumenis kas trys savaitės ir 5-fosfodiesterazės inhibitorius 1 valandą prieš lytinius santykius. Po 3 mėn. lytinės funkcijos pagal TEFR-5 skalę didesnis kaip 21 balas buvo 30 ligonių (85,7%). Rezultatai Hipogonadizmas yra klinikinis ir biocheminis sindromas, pasižymintis nepakankama androgenų koncentracija serume, dėl to gali sumažėti lytinė trauka, pablogėti erekcijos ir gyvenimo kokybė. Jei yra klinikinių indikacijų skirti androgenų terapiją, ja testosterono koncentracija turi būti palaikoma neviršijant fiziologinių ribų. Egzistuoja terapinis sinergizmas, kai esant hipogonadizmui taikomas kombinuotasis gydymas testosteronu ir 5-fosfodiesterazės inhibitoriais. Prieš terapiją ir reguliariai po jos būtina atlikti prostatos digitalinę rektalinę apžiūrą ir nustatyti prostatos specifinius antigenus kraujo serume. Androgenų terapija gali būti trumpalaikė arba ilgalaikė. Pastarajai reikia reguliariai ir dažnai stebėti pacientą, palankų bei šalutinį terapijos atsaką. Išvados Gydant pagyvenusių vyrų lytinę disfunkciją būtina atsižvelgti ir į steroidinių hormonų kiekį kraujo serume bei androgenų terapijos galimybes. Kombinuotąjį gydymą testosteronu ir 5-fosfodiesterazės inhibitoriais reikėtų skirti tiems erekcijos sutrikimų turintiems pacientams, kuriems nepakankamai padeda gydymas vien 5-fosfodiesterazės inhibitoriais. Reikšminiai žodžiai: lytinė disfunkcija; androgenai; andropauzė; testosteronas; prolaktinas dihidrotestosteronas, 5-fosfodiesterazės inhibitoriai, hormonų terapija Androgen aspects of male sexual dysfunction Antanas BalvočiusInternational Medical Center Union Clinic Vilnius,Tilto str. 1/2, Vilnius, LithuaniaE-mail: balvociusa@delfi.lt Background / objective Steroid hormone endocrine disturbances have an adverse impact on sexual function in men. The aim of the article was to present findings of the study on sexual dysfunction in elderly men and results of their treatment together with a review of the literature on pathologic physiology, diagnostics and therapy of male endocrine sexual dysfunction. Patients and methods Sixty four elderly men (aged 50 to 75, mean age 59 years) were treated for sexual dysfunction. The score of erectile disturbances according to International Index of Erectile Function TEFR-5scale ranged from 11 to 21 (mean, 15.5). The blood testosterone (T) level was 15.8 to 4.6 nmol/l. The level lower than 11 nmol/l was found in 44 (69%) patients. Only 46 of 64 patients were not satisfied with the quality of erection after administration of PDE-5 inhibitors. A combined therapy was applied for 35 of 46 patients with a low T level: intramuscular T 250 mg injections three times a week and a FED-5 inhibitor one hour before sexual intercourse. Sexual function of >21 as assessed by TEFR-5 scale was determined for 30 (85.7%) patients after three months. Results Hypogonadism is a clinical and biochemical syndrome characterised by an insufficient serum androgen level, which may result in a decreased libido, lower quality of erection and decreased quality of life. If clinical indications for androgen therapy are present, it shall maintain the level of testosterone within the physiological limits. Therapeutic synergism is observed when a combined treatment including testosterone and phosphodiesterase-5 inhibitors is applied in hypogonadic men. Digital rectal examination of prostate and determination of values of blood serum prostate specific antigens are indispensable before the initiation of therapy and must be performed regularly afterwards. Androgen therapy may be short-term or long-term, and requires regular and frequent monitoring and observation for favourable and side response to the treatment. Conclusions The level of blood serum steroid hormones should be taken into account and the possibilities for androgen therapy considered in the therapy of sexual dysfunctions in elderly men. A combined treatment of erectile disorders with testosterone and phosphodiesterease-5 inhibitors should be administered to the patients in whom the treatment with phosphodiesterease-5 inhibitors alone is not helpful. Keywords: sexual dysfunction, androgens, andropause, testosterone, prolactin, dihydrotestosterone, phosphodiesterease-5 inhibitors, hormone therapy
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Geniole, Shawn N., Tanya L. Procyshyn, Nicole Marley, Triana L. Ortiz, Brian M. Bird, Ashley L. Marcellus, Keith M. Welker, et al. "Using a Psychopharmacogenetic Approach To Identify the Pathways Through Which—and the People for Whom—Testosterone Promotes Aggression." Psychological Science 30, no. 4 (February 21, 2019): 481–94. http://dx.doi.org/10.1177/0956797619826970.
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Little is known about the neurobiological pathways through which testosterone promotes aggression or about the people in whom this effect is observed. Using a psychopharmacogenetic approach, we found that testosterone increases aggression in men ( N = 308) with select personality profiles and that these effects are further enhanced among those with fewer cytosine-adenine-guanine (CAG) repeats in exon 1 of the androgen receptor (AR) gene, a polymorphism associated with increased AR efficiency. Testosterone’s effects were rapid (~30 min after administration) and mediated, in part, by subjective reward associated with aggression. Testosterone thus appears to promote human aggression through an AR-related mechanism and to have stronger effects in men with the select personality profiles because it more strongly upregulates the subjective pleasure they derive from aggression. Given other evidence that testosterone regulates reward through dopaminergic pathways, and that the sensitivity of such pathways is enhanced among individuals with the personality profiles we identified, our findings may also implicate dopaminergic processes in testosterone’s heterogeneous effects on aggression.
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Banov, Daniel, Bruce Biundo, Kendice Ip, Ashley Shan, Fabiana Banov, Guiyun Song, and Maria Carvalho. "Testosterone Therapy for Late-Onset Hypogonadism: A Clinical, Biological, and Analytical Approach Using Compounded Testosterone 0.5–20% Topical Gels." Pharmaceutics 16, no. 5 (May 6, 2024): 621. http://dx.doi.org/10.3390/pharmaceutics16050621.
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Testosterone is integral to men’s sexual and overall health, but there is a gradual decline in the ageing male. The topical administration of testosterone is a valuable option as a supplement (replacement) therapy to alleviate hypogonadal symptoms. The clinical efficacy of a compounded testosterone 5% topical gel was assessed retrospectively in a male patient in his seventies by evaluating the laboratory testing of the serum total testosterone and the results of a validated androgen deficiency questionnaire. After treatment, the patient’s hypogonadal symptoms improved and the serum total testosterone level achieved was considered clinically optimal. The skin permeation of the testosterone topical gel (biological testing) was evaluated in vitro using the Franz finite dose model and human cadaver skin, and it is shown that testosterone can penetrate into and through ex vivo human skin. Testosterone therapy is often prescribed for extended periods, and consequently, it is crucial to determine the beyond-use date of the compounded formulations. The analytical testing involved a valid, stability-indicating assay method for compounded testosterone 0.5% and 20% topical gels. This multidisciplinary study shows evidence supporting topically applied testosterone’s clinical efficacy and the compounded formulations’ extended stability. Personalized, topical testosterone therapy is a promising alternative in current therapeutics for hypogonadal patients.
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Littleton-Kearney, Marguerite, and Patricia D. Hurn. "Testosterone as a Modulator of Vascular Behavior." Biological Research For Nursing 5, no. 4 (April 2004): 276–85. http://dx.doi.org/10.1177/1099800403262927.
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Male sex is an acknowledged risk factor for many forms of cardiovascular disease, and vascular disease prevalence patterns appear to be different in men versus women. The vascular properties of the principal mammalian androgen, testosterone, are complex and linked to dose, duration of exposure, presence of underlying vascular disease, and, possibly, biological sex. Data from isolated vessels and animal models suggest that pharmacological doses of testosterone, or its potent intracellular metabolite dihydrotestosterone, produce vasodilation. Testosterone’s major effect on vascular beds at physiologic concentrations remains unclear, with documentation of both vasodilatory and vasoconstrictive actions. Results of various studies suggest that testosterone can alter vascular tone through both endothelium-dependent and endothelium-independent mechanisms in a variety of vascular beds and vessel types. Testosterone’s endothelium-dependent effects are likely mediated at least in part through nitric oxide (NO) elaboration, whereas mechanisms of endothelium-independent effects involve 1 or more types of smooth muscle ion conductance channels. Data from clinical studies indicate that, in men, androgen replacement may provide beneficial effects when coronary artery disease is present. Conversely, in women, testosterone may augment existing hypertension, increase risk for cardio-vascular events, or promote atherogenesis. However, it should be emphasized that most of these observations are anecdotal or come from small-scale clinical studies, and limited information is available in women. New research is required to understand the potential efficacy of androgen therapy, or lack thereof. This review focuses on current understanding of testosterone’s physiological effects on vascular behavior and of testosterone’s putative role in vascular health and disease.
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Enter, Dorien, Philip Spinhoven, and Karin Roelofs. "Dare to Approach." Clinical Psychological Science 4, no. 6 (July 7, 2016): 1073–79. http://dx.doi.org/10.1177/2167702616631499.
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Persistent fear and avoidance in patients with social anxiety disorder (SAD) has been associated with reduced testosterone levels. Because threat avoidance is a major maintaining factor in SAD, and because testosterone administration promotes social approach, we tested whether testosterone administration can directly facilitate threat approach behavior in SAD. In a double-blind, placebo-controlled study, 17 female participants with SAD received a single dose of testosterone before performing a well-established social Approach-Avoidance Task. This objective implicit measure of social motivational action tendencies requires participants to approach or avoid visually presented emotional faces. After testosterone administration, the patients showed increased approach tendencies to angry facial expressions. These results suggest that testosterone can counteract persistent automatic social avoidance tendencies in SAD. This finding advances our understanding of steroid involvement in the regulation of social motivational action in general and in SAD in particular, and may have important clinical implications, promoting testosterone’s candidacy for pharmacological treatment-enhancement studies.
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Gouveia, Maria, Raquel Sanches, Sara Andrade, Sara Carmona, and Carolina Ferreira. "O Papel da Testosterona na Melhoria do Desejo Sexual da Mulher Pós-Menopáusica: Uma Revisão Baseada na Evidência." Acta Médica Portuguesa 31, no. 11 (November 30, 2018): 680. http://dx.doi.org/10.20344/amp.9277.
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Introduction: Female sexual dysfunction is a common problem, affecting more than 1/3 of women during their lives. The aim of this review is to review the evidence for the effectiveness of testosterone in sexual dysfunction in postmenopausal women, particularly in the improvement of sexual desire.Material and Methods: The authors searched in international databases National Guidelines Clearinghouse, Guidelines Finder, Cochrane Library and MEDLINE/PubMed, for guidelines, systematic reviews, meta-analysis and randomized controlled trials, published between January 2005 and February 2017, using the MeSH terms ‘testosterone’, ‘androgens’, ‘libido’, ‘sexual dysfunctions’ and ‘menopause’.Results: From a pool of 506 articles, 11 were selected: three guidelines, one systematic review with meta-analysis and seven randomized controlled trials. The selected articles showed testosterone‘s efficacy on global sexual function and improvement of sexual desire in postmenopausal women, when both are used in monotherapy or in association with other hormones. No study showed changes in hepatic enzymes or serious adverse effects.Discussion: The small sample size and short follow-up used in the included studies limits the ability to assess testosterone’s long-term benefits and effects.Conclusion: At short-term, testosterone seems to improve sexual function in postmenopausal women, particularly sexual desire. Nevertheless, more studies with larger sample size and longer follow-up are needed to understand its long-term safety and effectiveness.
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Cashdan, Elizabeth. "Why is testosterone associated with divorce in men?" Behavioral and Brain Sciences 21, no. 3 (June 1998): 366. http://dx.doi.org/10.1017/s0140525x9826122x.
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There is evidence that in women high levels of testosterone are associated with more sexual partners and more permissive sexual attitudes. If a similar relationship holds true for men, the higher basal testosterone levels of divorced and unmarried men may be caused by this relationship rather than by testosterone's effect on dominance striving.
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BOBOC, Daniela, Manole COJOCARU, and Natalia ROȘOIU. "THE INFLUENCE OF TESTOSTERONE ON THE BEHAVIOR OF THE AUTISTIC CHILD." Annals of the Academy of Romanian Scientists Series on Biological Sciences 13, no. 1 (June 20, 2024): 120–31. http://dx.doi.org/10.56082/annalsarscibio.2024.1.120.
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Background The impact of testosterone on autism symptoms is still being studied, and the precise mechanisms are not yet fully understood. Objectives Numerous studies have been conducted to investigate the relationship between autism and testosterone levels. The biochemical analysis of testosterone is important to perform for boys, especially for those diagnosed with autism spectrum disorders who also present a high level of aggression. Materials and methods While the exact causes of autism are still unknown, researchers have been studying the relationship between autism and testosterone levels in the body. It is suggested that testosterone may play a role in the higher prevalence of autism spectrum disorder to males compared to females. This has led researchers to investigate whether there is a link between autism and testosteronem. Results Some studies have reported higher levels of testosterone in individuals with autism compared to those without autism. After analyzing the results obtained in our study, higher values of testosterone are observed in children diagnosed with ASD compared to those without ASD who form the control group, but from a statistical point of view there are no significant differences. Some researchers propose that testosterone may have an effect on certain behaviors and characteristics commonly observed in individuals with autism. Studies have shown that children with autism tend to have higher levels of testosterone in their bodies than children without autism. It is important to note that not all children with autism have high levels of testosterone, and not all children with high levels of testosterone have autism. Conclusions These varying results may be attributed to the heterogeneity of autism itself, as it encompasses a wide range of symptoms and characteristics. Early intervention is the key and children with autism can benefit from therapies such as speech therapy, occupational therapy and behavioral therapy. More researches are needed to fully understand the relationship between autism and testosterone.
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Sembiring, Dewi Prisca, and Dr Soetjipto. "Korelasi Antara Kadar Testosteron Total dengan Kepribadian Antisosial dan Jenis Kriminalitas pada Penghuni Lapas Jember." Jurnal Psikiatri Surabaya 6, no. 2 (December 8, 2017): 79. http://dx.doi.org/10.20473/jps.v6i2.19431.
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Latarbelakang. Hormon testosterone telah lama diasosiasikan dengan berbagai macam sifat pria pada umumnya dan berhubungan dengan perilaku agresif, dominasi dan kepribadian antisocial dalam berbagai kondisi masyarakat, bahkan dalam beberapa kasus disebutkan tin dakan criminal menjadi salah satu efek dari tingginya kadar hormonini.Tujuan. Korelasi antara kadar hormone testosteron total pada penghuni Lapas Jember, dengan kepribadian antisosial yang dimiliki dan jenis kriminal yang dilakukan.Metode. Studi kuantitatif cross sectional. Menggunakan form MCMI-IV dan uji kadar terstosteron total pada pukul 8 – 10 Pagi. Uji statistic dengan metode chi square.Hasil. Mayoritasresponden (82 %) memiliki kadar testosteron total normal (antara 3,0-10,6 ng/ml), 13% kadar testosteron yang rendah, dan 5 % kadar testosterone tinggi. 29 % kepribadian anti sosial, dan 71 % kepribadian bukan anti sosial. 82 % melakukan tindak kriminalitas non seksual dan 18 % terpidana tindak kriminalitas seksual.Simpulan. Tidak diperoleh hubungan antara kadar testosteron total dengan kepribadian dan jenis kriminalitas.
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Dayan, Dan, Avital Kozlovsky, Haim Tal, Noam Kariv, Mordechai Shemesh, and Abraham Nyska. "Castration prevents calcium channel blocker-induced gingival hyperplasia in beagle dogs." Human & Experimental Toxicology 17, no. 7 (July 1998): 396–402. http://dx.doi.org/10.1177/096032719801700706.
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1 The purpose of this study was to investigate testosterone's role on the calcium channel antagonist oxodi-pine-inducing gingival hyperplasia in a dog model. 2 Two experiments were conducted using castrated and intact male dogs. Oxodipine was administered orally for 90 days, at a dose of 24 mg/kg/day. In the first experiment, the occurrence of gingival hyperplasia was evaluated. In the second, the gingival index (GI) and gingival hyperplasia index (GHI) were recorded and correlated with serum levels of testosterone. 3 A significant positive correlation between GI, GHI and plasma testosterone was noted. Castrated dogs were injected with testosterone, 4 months after the start of oxodipine treatment, while in the non-castrated dogs, administration of oxodipine was stopped. Castration correlated with lack of GH, while testosterone injection to the same dogs was associated with an increase of GI and GHI. 4 Since it is known that testosterone receptors are present in the gingiva, it is proposed that oxodipine-induced gingival hyperplasia could be mediated by the calcium channel blocker on plasma testosterone levels.
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Osadshiy, Y., and V. Soldatkin. "Depression in men with testosterone deficiency (Preliminary results of the study)." European Psychiatry 65, S1 (June 2022): S319—S320. http://dx.doi.org/10.1192/j.eurpsy.2022.813.
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Introduction Clinical practice in psychiatry is shifting toward personalized approach. In other words, clinicians aim to help patients based on their individual characteristics. It’s known that testosterone play a crucial role in the regulation of the emotions specially in men. The problems of hypogonadism and its possible role as an etiological factor in the development of depression in men are available in detail. But there is no solid date about the features of depression in men with testosteron defficency and theraputic approach including testosterone replacement therapy and antidepressants. Objectives Аssessment of efficiency of different pharmacological approaches in the treatment of depression in men with testosterone deficiency Methods The main group included 37 men with a depressive episode that arose against the background of a decrease in testosterone levels (≤12.1 nmol / L). A depressive episode was diagnosed based on the ICD-10 criteria for a depressive episode (F32). Patients were randomized into 3 treatment groups, depending on the received treatment: 1) sertraline; 2) testosterone gel; 3) sertraline + testosterone gel. The control group consisted of men (n = 40) aged 18 to 65 years, suffering from depression in accordance with the ICD-10 criteria with normal testosterone levels Results An insufficient effectiveness of antidepressant monotherapy in relation to sexual dysfunction was found in main group, while testosterone monotherapy did not give statistically significant improvements in depression indicators. Conclusions Combination therapy was most effective for the main symptoms and can be regarded as the most appropriate algorithm for the treatment of depression in men with low testosterone levels Disclosure No significant relationships.
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Arini, Luh Ari. "Studi Literatur Perbedaan Ekspresi Messenger Ribonucleid Acid (mRNA) Reseptor Androgen Setelah Pemberian Testosteron antara Penis dan Kelenjar Prostat Tikus Wistar Jantan (Rattus Norvegicus) Pascakastrasi." Jurnal Kesehatan Reproduksi 6, no. 1 (May 31, 2019): 29. http://dx.doi.org/10.22146/jkr.37823.
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Background: Aging process (andropause) in men will cause a decrease in testosterone hormones, in other that decrese of androgen receptor (testosteron and dhyhidrtestosterone) in target organ, can be seen from AR mRNA expression. Andropause finaly impact of male reproductive organ, so given testosterone hormone therapy is important to restore the condition. Giving testosterone hormone causes increase the expression of AR mRNA in the prostate gland and penis, but in these two organs there is a different increase.Objective: to know the difference of expression AR mRNA after administration of testosterone between prostate gland and penis.Method: This article used literature review from database of intisari sains medis.Results and Discussion: AR mRNA expression in the prostate gland is smaller than the penile tissue, due to the prostate gland in addition to the 5α reductase enzyme there are also many aromatase enzymes. In the normal prostate gland the amount of 5α reductase is small, so the addition of testosterone is converted to DHT but also in aromatization to estrogen. Therefore, fewer androgen receptors are found compared to the tissue of the penis, in addition expression of AR mRNA in the preputial penis is higher than the prostate gland.Conclusion: Penile tissue is more responsive to testosterone and improves the function and maintenance of tissue especially in old. Keywords: androgen receptor mRNA; testosterone; penis and prostate
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Cheng, Jian, Weidong Hu, Thomas J. Toung, Zhizheng Zhang, Susan M. Parker, Charles E. Roselli, and Patricia D. Hurn. "Age-Dependent Effects of Testosterone in Experimental Stroke." Journal of Cerebral Blood Flow & Metabolism 29, no. 3 (November 12, 2008): 486–94. http://dx.doi.org/10.1038/jcbfm.2008.138.
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Although male sex is a well-recognized risk factor for stroke, the role of androgens in cerebral ischemia remains unclear. Therefore, we evaluated effects of testosterone on infarct size in both young adult and middle-aged rats (Wistar, 3-month versus 14-month old) and mice (C57/BL6, 3-month versus 12-month old) subjected to middle cerebral artery occlusion. In young adult groups, castrates displayed less ischemic damage as compared with intact males and castrates with testosterone replacement (Cortex: 24% in castrates versus 42% in intact versus 40% with testosterone; Striatum: 45% versus 73% versus 70%) at 22 h reperfusion. Surprisingly, supplementing testosterone in middle-aged rats to the physiologic levels ordinarily seen in young males reduced infarction (Cortex: 2% with testosterone versus 31%; Striatum: 38% with testosterone versus 68%). Testosterone effects on infarct size were blocked by the androgen receptor (AR) antagonist flutamide and further confirmed in young versus middle-aged mice. Baseline cerebral aromatase mRNA levels and activity were not different between young and middle-aged rats. Aromatase activity increased in ischemic tissue, but only in young males. Lastly, stroke damage was not different in aging aromatase knockout mice versus wild-type controls. Our findings indicate that testosterone's effects in experimental stroke are age dependent, mediated via AR, but not cerebral aromatase.
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Traustadóttir, Tinna, S. Mitchell Harman, Panayiotis Tsitouras, Karol M. Pencina, Zhuoying Li, Thomas G. Travison, Richard Eder, et al. "Long-Term Testosterone Supplementation in Older Men Attenuates Age-Related Decline in Aerobic Capacity." Journal of Clinical Endocrinology & Metabolism 103, no. 8 (May 25, 2018): 2861–69. http://dx.doi.org/10.1210/jc.2017-01902.
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Abstract Context Testosterone increases skeletal muscle mass and strength, but long-term effects of testosterone supplementation on aerobic capacity, or peak oxygen uptake (V̇O2peak), in healthy older men with low testosterone have not been evaluated. Objective To determine the effects of testosterone supplementation on V̇O2peak during incremental cycle ergometry. Design A double-blind, randomized, placebo-controlled, parallel-group trial (Testosterone’s Effects on Atherosclerosis Progression in Aging Men). Setting Exercise physiology laboratory. Participants Healthy men aged ≥ 60 years with total testosterone levels of 100 to 400 ng/dL (3.5 to 13.9 nmol/L) or free testosterone levels < 50 pg/mL (174 pmol/L). Interventions Randomization to 1% transdermal testosterone gel adjusted to achieve serum levels of 500 to 950 ng/dL or placebo applied daily for 3 years. Main Outcome Measures Change in V̇O2peak. Results Mean (±SD) baseline V̇O2peak was 24.2 ± 5.2 and 23.6 ± 5.6 mL/kg/min for testosterone and placebo, respectively. V̇O2peak did not change in men treated with testosterone but fell significantly in men receiving placebo (average 3-year decrease, 0.88 mL/kg/min; 95% CI, −1.39 to 0.38 mL/kg/min; P = 0.035); the difference in change in V̇O2peak between groups was significant (average 3-year difference, 0.91 mL/kg/min; 95% CI, 0.010 to 0.122 mL/kg/min; P = 0.008). The 1-g/dL mean increase in hemoglobin (P < 0.001) was significantly associated with changes in V̇O2peak in testosterone-treated men. Conclusion The mean 3-year change in V̇O2peak was significantly smaller in men treated with testosterone than in men receiving placebo and was associated with increases in hemoglobin. The difference in V̇O2peak change between groups may indicate attenuation of its expected age-related decline; the clinical meaningfulness of the modest treatment effect remains to be determined.
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Dreher, Jean-Claude, Simon Dunne, Agnieszka Pazderska, Thomas Frodl, John J. Nolan, and John P. O’Doherty. "Testosterone causes both prosocial and antisocial status-enhancing behaviors in human males." Proceedings of the National Academy of Sciences 113, no. 41 (September 26, 2016): 11633–38. http://dx.doi.org/10.1073/pnas.1608085113.
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Although popular discussion of testosterone’s influence on males often centers on aggression and antisocial behavior, contemporary theorists have proposed that it instead enhances behaviors involved in obtaining and maintaining a high social status. Two central distinguishing but untested predictions of this theory are that testosterone selectively increases status-relevant aggressive behaviors, such as responses to provocation, but that it also promotes nonaggressive behaviors, such as generosity toward others, when they are appropriate for increasing status. Here, we tested these hypotheses in healthy young males by injecting testosterone enanthate or a placebo in a double-blind, between-subjects, randomized design (n = 40). Participants played a version of the Ultimatum Game that was modified so that, having accepted or rejected an offer from the proposer, participants then had the opportunity to punish or reward the proposer at a proportionate cost to themselves. We found that participants treated with testosterone were more likely to punish the proposer and that higher testosterone levels were specifically associated with increased punishment of proposers who made unfair offers, indicating that testosterone indeed potentiates aggressive responses to provocation. Furthermore, when participants administered testosterone received large offers, they were more likely to reward the proposer and also chose rewards of greater magnitude. This increased generosity in the absence of provocation indicates that testosterone can also cause prosocial behaviors that are appropriate for increasing status. These findings are inconsistent with a simple relationship between testosterone and aggression and provide causal evidence for a more complex role for testosterone in driving status-enhancing behaviors in males.
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Coviello, Andrea D., Kishore Lakshman, Norman A. Mazer, and Shalender Bhasin. "Differences in the Apparent Metabolic Clearance Rate of Testosterone in Young and Older Men with Gonadotropin Suppression Receiving Graded Doses of Testosterone." Journal of Clinical Endocrinology & Metabolism 91, no. 11 (November 1, 2006): 4669–75. http://dx.doi.org/10.1210/jc.2006-0822.
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Abstract Background: Recently we found that testosterone levels are higher in older men than young men receiving exogenous testosterone. We hypothesized that older men have lower apparent testosterone metabolic clearance rates (aMCR-T) that contribute to higher testosterone levels. Objective: The objective of the study was to compare aMCR-T in older and young men and identify predictors of aMCR-T. Methods: Sixty-one younger (19–35 yr) and 60 older (59–75 yr) men were given a monthly GnRH agonist and weekly testosterone enanthate (TE) (25, 50, 125, 300, or 600 mg) for 5 months. Estimated aMCR-T was calculated from the amount of TE delivered weekly and trough serum testosterone concentrations, corrected for real-time absorption kinetics from the im testosterone depot. Results: Older men had lower total (316 ± 13 vs. 585 ± 26 ng/dl, P < 0.00001) and free testosterone (4 ± 0.1 vs. 6 ± 0.3 ng/dl, P < 0.00001) and higher SHBG (52 ± 3 vs. 33 ± 2 nmol/liter, P < 0.00001) than younger men at baseline. Total and free testosterones increased with TE dose and were higher in older men than young men in the 125-, 300-, and 600-mg dose groups. aMCR-T was lower in older men than young men (1390 ± 69 vs. 1821 ± 102 liter/d, P = 0.006). aMCR-T correlated negatively with age (P = 0.0007), SHBG (P = 0.046), and total testosterone during treatment (P = 0.02) and percent body fat at baseline (P = 0.01) and during treatment (P = 0.004). aMCR-T correlated positively with lean body mass at baseline (P = 0.03) and during treatment (P = 0.01). In multiple regression models, significant predictors of aMCR-T included lean body mass (P = 0.008), percent fat mass (P = 0.009), and SHBG (P = 0.001). Conclusions: Higher testosterone levels in older men receiving TE were associated with an age-related decrease in apparent testosterone metabolic clearance rates. Body composition and SHBG were significant predictors of aMCR-T.
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Clay, Patrick G., and Amy I. Lam. "Testosterone Replacement Therapy for Bone Loss Prevention in HIV-Infected Males." Annals of Pharmacotherapy 37, no. 4 (April 2003): 582–85. http://dx.doi.org/10.1345/aph.1c345.
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OBJECTIVE: To review the use of testosterone for the prevention of bone loss in men with HIV infection. DATA SOURCES: A MEDLINE search (1966–May 2002) on the use of testosterone in osteoporosis/HIV infection was performed. A reference bibliography search was also completed. DATA SYNTHESIS: Osteopenia/osteoporosis is reported in HIV-infected men due to a myriad of factors. Sex hormone deficiency is a frequent endocrine abnormality in this population. CONCLUSIONS: In HIV-negative men, testosterone may be beneficial for preventing bone loss and hastening the resolution of fractures. Testosterone's role in preventing bone loss in HIV-infected men remains to be defined.
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Culbert, K. M., S. A. Burt, C. L. Sisk, J. T. Nigg, and K. L. Klump. "The effects of circulating testosterone and pubertal maturation on risk for disordered eating symptoms in adolescent males." Psychological Medicine 44, no. 11 (January 9, 2014): 2271–86. http://dx.doi.org/10.1017/s0033291713003073.
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BackgroundTestosterone may be a biological factor that protects males against eating disorders. Elevated prenatal testosterone exposure is linked to lower levels of disordered eating symptoms, but effects emerge only after mid-puberty. Whether circulating levels of testosterone account for decreased risk for disordered eating in boys after mid-puberty is currently unknown; however, animal data support this possibility. In rodents, prenatal testosterone's masculinizing effects on sex-differentiated behaviors emerge during puberty when circulating levels of testosterone increase and ‘activate’ the expression of masculinized phenotypes. This study investigated whether higher levels of circulating testosterone predict lower levels of disordered eating symptoms in adolescent boys, and in particular whether effects are associated with advancing pubertal maturation.MethodParticipants were 213 male twins from the Michigan State University Twin Registry. The Minnesota Eating Behavior Survey and Eating Disorder Examination Questionnaire assessed several disordered eating symptoms. The Pubertal Development Scale assessed pubertal status. Afternoon saliva samples were assayed for testosterone using enzyme immunoassays.ResultsConsistent with animal data, higher levels of circulating testosterone predicted lower levels of disordered eating symptoms in adolescent boys and effects emerged with advancing puberty. Results were not accounted for by several important covariates, including age, adiposity, or mood/anxiety symptoms.ConclusionsFindings suggest that elevated circulating testosterone may be protective and underlie decreased risk for eating pathology in males during/after puberty, whereas lower levels of testosterone may increase risk and explain why some, albeit relatively few, males develop eating disorders.
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Harris, Autumn N., Hyun-Wook Lee, Jill W. Verlander, and I. David Weiner. "Testosterone modulates renal ammonia metabolism." American Journal of Physiology-Renal Physiology 318, no. 4 (April 1, 2020): F922—F935. http://dx.doi.org/10.1152/ajprenal.00560.2019.
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There are substantial sex differences in renal structure and ammonia metabolism that correlate with differences in expression of proteins involved in ammonia generation and transport. This study determined the role of testis-derived testosterone in these differences. We studied 4-mo-old male C57BL/6 mice 4 and 8 wk after either bilateral orchiectomy (ORCH) or sham-operated control surgery and determined the effect of testosterone replacement to reverse the effects of ORCH. Finally, we determined the cellular expression of androgen receptor (AR), testosterone’s canonical target receptor. ORCH decreased kidney and proximal tubule size, and testosterone replacement reversed this effect. ORCH increased ammonia excretion in a testosterone-dependent fashion; this occurred despite similar food intake, which is the primary component of endogenous acid production. ORCH increased expression of both phospho enolpyruvate, a major ammonia-generating protein, and Na+-K+-2Cl− cotransporter, which mediates thick ascending limb ammonia reabsorption; these changes were reversed with testosterone replacement. Orchiectomy also decreased expression of Na+/H+ exchanger isoform 3, which mediates proximal tubule ammonia secretion, in a testosterone-dependent pattern. Finally, ARs are expressed throughout the proximal tubule in both the male and female kidney. Testosterone, possibly acting through ARs, has dramatic effects on kidney and proximal tubule size and decreases ammonia excretion through its effects on several key proteins involved in ammonia metabolism.
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Maharjan, Dhruba Tara, Ali Alamdar Shah Syed, Guan Ning Lin, and Weihai Ying. "Testosterone in Female Depression: A Meta-Analysis and Mendelian Randomization Study." Biomolecules 11, no. 3 (March 10, 2021): 409. http://dx.doi.org/10.3390/biom11030409.
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Testosterone’s role in female depression is not well understood, with studies reporting conflicting results. Here, we use meta-analytical and Mendelian randomization techniques to determine whether serum testosterone levels differ between depressed and healthy women and whether such a relationship is casual. Our meta-analysis shows a significant association between absolute serum testosterone levels and female depression, which remains true for the premenopausal group while achieving borderline significance in the postmenopausal group. The results from our Mendelian randomization analysis failed to show any causal relationship between testosterone and depression. Our results show that women with depression do indeed display significantly different serum levels of testosterone. However, the directions of the effect of this relationship are conflicting and may be due to menopausal status. Since our Mendelian randomization analysis was insignificant, the difference in testosterone levels between healthy and depressed women is most likely a manifestation of the disease itself. Further studies could be carried out to leverage this newfound insight into better diagnostic capabilities culminating in early intervention in female depression.
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Pruneda-Paz, José Luis, Mauricio Linares, Julio E. Cabrera, and Susana Genti-Raimondi. "TeiR, a LuxR-Type Transcription Factor Required for Testosterone Degradation in Comamonas testosteroni." Journal of Bacteriology 186, no. 5 (March 1, 2004): 1430–37. http://dx.doi.org/10.1128/jb.186.5.1430-1437.2004.
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ABSTRACT We have identified a new steroid-inducible gene (designated teiR [testosterone-inducible regulator]) in Comamonas testosteroni that is required for testosterone degradation. Nucleotide sequence analysis of teiR predicts a 391-amino-acid protein which shows homology between residues 327 and 380 (C-terminal domain) to the LuxR helix-turn-helix DNA binding domain and between residues 192 and 227 to the PAS sensor domain. This domain distribution resembles that described for TraR, a specific transcriptional regulator involved in quorum sensing in Agrobacterium tumefaciens. Analysis of the gene expression indicated that teiR is tightly controlled at the transcriptional level by the presence of testosterone in the culture medium. A teiR-disrupted mutant strain was completely unable to use testosterone as the sole carbon and energy source. In addition, the expression of several steroid-inducible genes was abolished in this mutant. Northern blot assays revealed that teiR is required for full expression of sip48-β-HSD gene mRNA (encoding a steroid-inducible protein of 48 kDa and 3β-17β-hydroxysteroid dehydrogenase) and also of other steroid degradation genes, including those encoding 3α-hydroxysteroid dehydrogenase, Δ5-3-ketoisomerase, 3-oxo-steroid Δ1-dehydrogenase, and 3-oxo-steroid Δ4-(5α)-dehydrogenase enzymes. Moreover, when teiR was provided to the teiR-disrupted strain in trans, the transcription level of these genes was restored. These results indicate that TeiR positively regulates the transcription of genes involved in the initial enzymatic steps of steroid degradation in C. testosteroni.
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Dănciulescu Miulescu, Rucsandra, Suzana Dănoiu, Denisa Margină, Sorin Păun, and Cătălina Poiană. "Dynamics of Prostate-Specific Antigen Levels During Treatment with Testosterone Undecanoate in Patients with Type 2 Diabetes Mellitus." Romanian Journal of Diabetes Nutrition and Metabolic Diseases 19, no. 4 (December 1, 2012): 397–403. http://dx.doi.org/10.2478/v10255-012-0046-9.
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AbstractObjectives. Prostate-specific antigen (PSA) is the most used and validated marker ofprostate cancer risk. The aim of this study was to assess PSA levels during treatmentwith testosteronum undecanoat in patients with type 2 diabetes (T2DM). Material and Methods. We evaluated 38 T2DM patients aged between 48 and 61 years withconfirmed hypogonadism. 1000 mg testosterone undecanoate was injectedintramuscular every 10 to 14 weeks. Total testosterone and PSA levels were assessedat baseline and after 6, 12, 24 months of treatment. Results. The average age was55.03 ± 2.40 years and 3 patients (7.89%) had a family history of prostate cancer.Treatment with testosterone undecanoate generated significant changes in serumtotal testosterone (482.29±50.78 ng/dl vs. 246.66±51.50 ng/dl, p < 0.001) but not inserum PSA levels (2.11±.0.49 ng/ml vs. 2.09±0.47 ng/ml, p - NS). Conclusion.Testosterone replacement therapy may normalize serum androgen levels but appearsto have little effect on PSA levels.
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Putri, Hylda Khairah, Muhammad Zairin Jr., Odang Carman, and Iis Diatin. "The use of different 17β-estradiol hormone doses and water temperatures to control cannibalism in catfish Clarias gariepinus seed." Jurnal Akuakultur Indonesia 19, no. 2 (November 20, 2020): 171–80. http://dx.doi.org/10.19027/jai.19.2.171-180.
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Cannibalism is a major problem in the intensive catfish hatchery that caused high mortality. This phenomenon is allegedly due to the high level of testosterone hormones in the early larvae and seed stages. Testosterone is a maternal steroid hormone that is transferred directly by the parent to the egg. Catfish broodstock has high testosterone levels during the gonad maturation phase and it enters the eggs during the process of vitellogenesis. A high level of testosterone is considered to cause catfish seeds to behave aggressively and subsequently encourage cannibalism. This testosterone level may be reduced by estrogen through a negative feedback mechanism. This experiment aimed to evaluate the use of several 17β-estradiol doses at different water temperatures to control cannibalism in catfish seeds. This experiment used two factors, i.e. 17β-estradiol doses (0, 20, and 50 mg/kg) coated in the diet and water temperatures (28 and 31°C). The results showed that 17β-estradiol levels in catfish seeds increased with increasing experimental length. The use of 17β-estradiol at low water temperature (28°C) was better in decreasing mortality, while the dose of 50 mg/kg17β-estradiol which applied at 28°C was the best combination in controlling cannibalism on catfish seeds.
Keywords: 17β-estradiol, cannibalism, Clarias gariepinus, seed.
ABSTRAK
Kanibalisme merupakan salah satu masalah utama dalam pembenihan ikan lele intensif karena menyebabkan kematian yang tinggi. Fenomena ini diduga karena kadar hormon testosteron yang tinggi pada tahap larva dan benih. Testosteron merupakan hormon steroid maternal yang ditransfer secara langsung oleh induk ke telur. Induk ikan lele memiliki kadar testosteron yang tinggi pada fase pematangan gonad dan masuk ke dalam telur selama proses vitelogenesis. Tingginya kadar testosteron diduga menyebabkan benih berperilaku agresif dan akan mendorong kanibalisme. Kadar testosteron dapat ditekan dengan meningkatkan kadar hormon estrogen melalui mekanisme feedback negatif. Penelitian ini bertujuan mengevaluasi penggunaan dosis estradiol-17β dan suhu pemeliharaan yang berbeda untuk mengendalikan kanibalisme pada benih ikan lele. Penelitian ini menggunakan dua faktor yaitu dosis estradiol-17β yang berbeda (0, 20, dan 50 mg/kg) yang diberikan melalui pakan, dan suhu pemeliharaan yang berbeda (28 dan 31°C). Hasil penelitian menunjukkan bahwa konsentrasi estradiol-17β pada benih ikan lele meningkat seiring dengan lamanya pemeliharaan. Penggunaan estradiol-17β pada suhu 28°C lebih baik dalam mengurangi mortalitas, sementara dosis estradiol-17β 50 mg/kg pada suhu pemeliharaan 28°C adalah kombinasi terbaik dalam mengendalikan kanibalisme pada benih ikan lele.
Kata kunci: benih, Clarias gariepinus, estradiol-17β, kanibalisme.
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Ibero, Juan, Beatriz Galán, Eduardo Díaz, and José L. García. "Testosterone Degradative Pathway of Novosphingobium tardaugens." Genes 10, no. 11 (October 31, 2019): 871. http://dx.doi.org/10.3390/genes10110871.
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In this work, we have shown that Novosphingobium tardaugens NBRC 16725 (strain ARI-1), a bacterial strain that was isolated due to its capacity to mineralize the estrogenic endocrine compound 17β-estradiol, is also able to mineralize testosterone, the androgenic endocrine compound. Using in silico analysis, we predicted a new putative steroid degradation (SD) gene cluster in strain ARI-1, which resembles genes involved in testosterone degradation in Comamonas testosteroni and other testosterone degrading bacteria like Actinobacteria (like Rhodococcus and Mycobacteria genera) although with significant differences in gene organization. A whole transcriptomic analysis of N. tardaugens revealed that testosterone produces a limited induction of the genes of the SD cluster that show a high basal expression in its absence. The 3β/17β-hydroxysteroid dehydrogenase involved in the first metabolic step of testosterone degradation was identified by using genetic and biochemical approaches. The construction of knockout mutant strains in the genes of the SD cluster together with in silico analyses suggests the existence of gene redundancy in the genome of N. tardaugens. This work will expand the knowledge about the metabolic pathways and biotransformation capabilities of a Gram-negative bacterium that could become a new model system in the bacterial steroid degradation field.
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Lazarov, Georgi, and Vladislav Mladenov. "PERMANENT LOW NORMAL TESTOSTERONE LEVELS AND SEMINOLOGICAL DAMAGES IN MEN FROM 37 TO 45 YEARS OLD." Journal of IMAB - Annual Proceeding (Scientific Papers) 29, no. 2 (June 27, 2023): 5009–13. http://dx.doi.org/10.5272/jimab.2023292.5009.
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In our practice, we are increasingly seeing men aged from 37 to 45 years' old who have permanent low normal testosterone levels. Aim: We set out to investigate whether there is an association between permanent low normal testosterone levels and negative change in seminal fluid parameters in young men. Patients and Methods: For the period from January 2013 to December 2015 at the Andrology office at Hospital "St. Sofia" we examined 73 men aged 37 to 45 years with normal or elevated body mass index, permanent low normal testosterone level, and negative change in seminal fluid parameters. In order to compare the results we obtained, at the very beginning of the study we selected a control group of 20 healthy men of the same age. Results: We obtained, although within reference ranges, significantly lower values for total testosterone in the 73 men with negative change in seminal fluid parameters, compared with those in the control group without seminal damages (p<0.001) We found a high correlation relationship between the level of testosterone and the results of the first (r = 0.614, p<0.001) and second spermograms (r = 0.662, p<0.001). Conclusions: 1. Our study shows that in a number of men at a young age, some decrease in normal testosteronе secretion occurs, with a concomitant negative change in seminal fluid parameters, which is remarkably different from the same parameters in their peers with a high normal testosterone level. 2. We identify permanent low normal testosterone, overweight and obesity as predictors, signaling a possible negative change in seminal fluid parameters. 3. We can say that if obesity plays some role in seminal damages, the mechanism in most cases is most likely related to the sustained permanent low normal testosterone level, as a result of increased adipose tissue.
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Rice, Timothy R., and Leo Sher. "Low testosterone levels in aging men may mediate the observed increase in suicide in this age group." International Journal on Disability and Human Development 16, no. 1 (February 1, 2017): 123. http://dx.doi.org/10.1515/ijdhd-2016-0007.
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Abstract This short communication suggests that there may be biological in addition to psychosocial reasons underlying the rise in suicide among older men. Testosterone, the major male sex hormone, has attracted interest as a putative biological mediator of suicide risk, but observational data have been mixed. Age stratification may reveal that high levels of testosterone in adolescents and young adults but low levels in the elderly may mediate suicide risk. A putative age-testosterone-suicide differential may be mediated by divergent central nervous system architecture between adolescents and the elderly. Whereas the prefrontal and prefontal-limbic connectivity underdevelopment observed in adolescents may render vulnerability to testosterone-mediated increases in impulsivity as a risk factor for suicide, declining function of dopaminergic striato-thalamic reward pathways in the aging cohort may render older men vulnerable to the loss of testosterone’s protective effects against anhedonia, thereby increasing suicide risk through a different biological pathway. Further research is needed regarding the role of hypotestosteronemia in elderly suicide.
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Lazarov, Georgi, Philip Kumanov, and Vladislav Mladenov. "PERMANENT LOW NORMAL TESTOSTERONE AND LOWER URINARY TRACT SYMPTOMS IN MEN 35 - 45 YEARS OF AGE." Journal of IMAB - Annual Proceeding (Scientific Papers) 29, no. 1 (February 22, 2023): 4814–19. http://dx.doi.org/10.5272/jimab.2023291.4814.
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In our outpatient practice, we are increasingly seeing men aged 35 to 45 years who have permanent low normal testosterone levels. Aim We set out to investigate whether there is an association between permanent low normal testosterone levels and lower urinary tract symptoms in young men. Patients and Methods For the period from January 2013 to December 2015 at the Andrology office at Hospital "St. Sofia", we examined 73 men aged 35 to 45 years with normal or elevated body mass index, permanent low normal testosterone level and micturition disorders. In order to compare the results we obtained, at the very beginning of the study, we selected a control group of 20 healthy men of the same age. Results We obtained, although within reference ranges, significantly lower values for total testosterone in the 73 men with micturition disorders we studied, compared with those in the control group without micturition disorders. Conclusions 1. Our study shows that in some men at a young age, some deviation in normal testosteronе secretion occurs, with a concomitant decrease in maximum urine flow, which is remarkably different from the same indicator in their peers with a high normal testosterone level. 2. We identify permanent low normal testosterone, overweight, and obesity as predictors of initial lower urinary tract symptoms in young men. 3. According to our study, the altered E2/T ratio is also relevant to the initial onset of lower urinary tract symptoms in young men.
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Cross, Ericha, and Charles E. Roselli. "17β-Estradiol rapidly facilitates chemoinvestigation and mounting in castrated male rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 276, no. 5 (May 1, 1999): R1346—R1350. http://dx.doi.org/10.1152/ajpregu.1999.276.5.r1346.
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Testosterone and estradiol act synergistically to stimulate male sexual behavior. Previous studies demonstrated that testosterone’s actions are mediated genomically. Attempts to show that estradiol acts in a similar fashion have been inconclusive. However, estrogens have been shown to exert short-latency effects by acting directly on neuronal membranes. The present experiment examined whether testosterone or estradiol rapidly facilitates copulatory behaviors in castrated sexually experienced rats. Within 35 min of administration, estradiol stimulated chemoinvestigation and frequency of mounting and reduced mount latency in a dose-dependent manner. In contrast, acute administration of testosterone did not alter sexual activity. These data demonstrate for the first time that estradiol exerts short-latency effects on copulatory behavior, providing indirect evidence that this action is mediated through a nontranscriptional mechanism.
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Huang, Grace, Guilherme V. Rocha, Karol M. Pencina, Karen Cox, Venkatesh Krishnan, Kim Henriksen, Peter Mitchell, et al. "Circulating Biomarkers of Testosterone’s Anabolic Effects on Fat-Free Mass." Journal of Clinical Endocrinology & Metabolism 104, no. 9 (May 23, 2019): 3768–78. http://dx.doi.org/10.1210/jc.2019-00505.
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Abstract Background Biomarkers that predict response to anabolic therapies could expedite the development of function-promoting anabolic drugs. This study aimed to identify serum biomarkers that are responsive to testosterone administration and associated with increases in fat-free mass (FFM). Methods Serum samples were obtained from the 5α-Reductase Trial, a randomized trial that compared the effects of graded doses of testosterone enanthate for 20 weeks in healthy men randomized with placebo or dutasteride (dual SRD5A inhibitor). Testosterone’s effects on FFM or strength measures did not differ between placebo vs dutasteride groups. Accordingly, 54 subjects treated with testosterone plus placebo were included in the discovery cohort, and 48 subjects randomized to dutasteride were included in the validation cohort. A total of 1162 biomarkers were evaluated using prespecified criteria. Results In the discovery cohort, testosterone administration increased propeptide of type III collagen (PRO-C3) and propeptide of type VI collagen (PRO-C6) levels in a dose- and concentration-dependent manner; increases in these biomarkers from baseline to week 12 were associated with changes in FFM from baseline to week 20 (PRO-C3: r2 = 0.437, P < 0.001; PRO-C6: r2 = 0.434, P < 0.001). Changes in PRO-C3 and PRO-C6 levels were significantly associated with changes in chest press strength (PRO-C3: r2 = 0.394, P < 0.001; PRO-C6: r2 = 0.530, P < 0.001). In the SOMAscan, changes in IGF binding protein-6 (IGFBP6) and glypican 3 (GPC3) were associated with changes in total and free testosterone levels and FFM. These findings were replicated in the Validation cohort. Conclusion PRO-C3, PRO-C6, IGFBP6, and GPC3 fulfilled the prespecified criteria for biomarkers of testosterone-induced muscle anabolism. Changes in these biomarkers were associated with changes in total and free testosterone concentrations and with testosterone-induced gains in FFM.
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&NA;. "Testosterone." Reactions Weekly &NA;, no. 1376 (November 2011): 28–29. http://dx.doi.org/10.2165/00128415-201113760-00093.
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&NA;. "Testosterone." Reactions Weekly &NA;, no. 1381 (December 2011): 28. http://dx.doi.org/10.2165/00128415-201113810-00101.
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&NA;. "Testosterone." Reactions Weekly &NA;, no. 1385 (January 2012): 42. http://dx.doi.org/10.2165/00128415-201213850-00154.
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&NA;. "Testosterone." Reactions Weekly &NA;, no. 1388 (February 2012): 29. http://dx.doi.org/10.2165/00128415-201213880-00114.
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&NA;. "Testosterone." Reactions Weekly &NA;, no. 718 (September 1998): 12. http://dx.doi.org/10.2165/00128415-199807180-00029.
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&NA;. "Testosterone." Reactions Weekly &NA;, no. 759 (July 1999): 12. http://dx.doi.org/10.2165/00128415-199907590-00035.
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&NA;. "Testosterone." Reactions Weekly &NA;, no. 1163 (August 2007): 24. http://dx.doi.org/10.2165/00128415-200711630-00074.
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&NA;. "Testosterone." Reactions Weekly &NA;, no. 1134 (January 2007): 24. http://dx.doi.org/10.2165/00128415-200711340-00080.
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&NA;. "Testosterone." Reactions Weekly &NA;, no. 1140 (February 2007): 22. http://dx.doi.org/10.2165/00128415-200711400-00081.
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&NA;. "Testosterone." Reactions Weekly &NA;, no. 1159 (July 2007): 29. http://dx.doi.org/10.2165/00128415-200711590-00088.
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&NA;. "Testosterone." Reactions Weekly &NA;, no. 569 (September 1995): 12. http://dx.doi.org/10.2165/00128415-199505690-00040.
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&NA;. "Testosterone." Reactions Weekly &NA;, no. 467 (September 1993): 12. http://dx.doi.org/10.2165/00128415-199304670-00055.
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Neno, Rebecca. "Testosterone." Nursing Older People 20, no. 4 (May 2008): 8–9. http://dx.doi.org/10.7748/nop.20.4.8.s9.
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