Academic literature on the topic 'Testosterone'
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Journal articles on the topic "Testosterone"
Andriyanto, Aryani Sismin Satyaningtijas, Raden Yufiandri, Regina Wulandari, Vinda Mulyetti Darwin, and Santa Nova A. Siburi. "Performa dan Kecernaan Pakan Ayam Broiler yang diberi Hormon Testosteron dengan Dosis Bertingkat." Acta VETERINARIA Indonesiana 3, no. 1 (February 16, 2016): 29–37. http://dx.doi.org/10.29244/avi.3.1.29-37.
Full textQadarsina, Qadarsina, Dasrul Dasrul, and Sri Wahyuni. "Konsentrasi Hormon Testosteron Kerbau Simeulue dan Korelasinya dengan Tingkat Umur dan Lingkar Skrotum." Jurnal Agripet 19, no. 1 (April 1, 2019): 13–21. http://dx.doi.org/10.17969/agripet.v19i1.8692.
Full textBhasin, Shalendar. "How Does Testosterone Augment the Anabolic Response to Exercise in Frail Older Adults?" Innovation in Aging 5, Supplement_1 (December 1, 2021): 295. http://dx.doi.org/10.1093/geroni/igab046.1146.
Full textNave, Gideon, Amos Nadler, David Zava, and Colin Camerer. "Single-Dose Testosterone Administration Impairs Cognitive Reflection in Men." Psychological Science 28, no. 10 (August 3, 2017): 1398–407. http://dx.doi.org/10.1177/0956797617709592.
Full textConstantino, John N. "Dominance and aggression over the life course: Timing and direction of causal influences." Behavioral and Brain Sciences 21, no. 3 (June 1998): 369. http://dx.doi.org/10.1017/s0140525x9831122x.
Full textGrotzinger, Andrew D., Frank D. Mann, Megan W. Patterson, Jennifer L. Tackett, Elliot M. Tucker-Drob, and K. Paige Harden. "Hair and Salivary Testosterone, Hair Cortisol, and Externalizing Behaviors in Adolescents." Psychological Science 29, no. 5 (February 14, 2018): 688–99. http://dx.doi.org/10.1177/0956797617742981.
Full textLinares, Mauricio, José Luis Pruneda-Paz, Luciana Reyna, and Susana Genti-Raimondi. "Regulation of testosterone degradation in Comamonas testosteroni." Journal of Steroid Biochemistry and Molecular Biology 112, no. 1-3 (November 2008): 145–50. http://dx.doi.org/10.1016/j.jsbmb.2008.09.011.
Full textFedy, Bradley C., and Bridget J. M. Stutchbury. "Testosterone Does not Increase in Response to Conspecific Challenges in the White-Bellied Antbird (Myrmeciza Longipes), A Resident Tropical Passerine." Auk 123, no. 1 (January 1, 2006): 61–66. http://dx.doi.org/10.1093/auk/123.1.61.
Full textBalvočius, Antanas. "Vyrų sutrikusios lytinės funkcijos androgeniniai aspektai." Lietuvos chirurgija 3, no. 4 (January 1, 2005): 0. http://dx.doi.org/10.15388/lietchirur.2005.4.2302.
Full textGeniole, Shawn N., Tanya L. Procyshyn, Nicole Marley, Triana L. Ortiz, Brian M. Bird, Ashley L. Marcellus, Keith M. Welker, et al. "Using a Psychopharmacogenetic Approach To Identify the Pathways Through Which—and the People for Whom—Testosterone Promotes Aggression." Psychological Science 30, no. 4 (February 21, 2019): 481–94. http://dx.doi.org/10.1177/0956797619826970.
Full textDissertations / Theses on the topic "Testosterone"
Hopp, Renato Nicolás 1984. "Correlação entre a proporção 2D:4De o desempenho acadêmico em alunos de odontologia." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/289240.
Full textTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: Estudos sugerem que a exposição pré-natal à testosterona (PT) está relacionada à inteligência ou à capacidade de aprendizado. A proporção entre os dedos indicador e anelar (proporção digital ou 2D:4D) correlaciona-se negativamente à exposição pré-natal à testosterona. Este estudo avaliou as correlações entre o 2D:4D e o sucesso acadêmico em disciplinas teóricas e práticas no currículo do curso de Odontologia da Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas, Brasil. Ao todo, 80 indivíduos (40 homens e 40 mulheres) com idade entre 18 e 22 anos (média 19,5 ± 1,1 anos para os homens e 19,7 ± 1,2 para mulheres), alunos do 2º ao 4º ano de graduação tiveram sua mão direita fotografada por meio de câmera digital acoplada a dispositivo padronizador perpendicular à superfície. As imagens foram transferidas ao software Adobe Photoshop® e os dedos indicador e anelar foram medidos de forma linear, da depressão mais caudal ao ponto mais rostral da ponta do dedo. Os dados foram analisados usando os softwares Microsoft Excel, SPSS 16 e Statview. A proporção digital média foi de 0,980 ± 0,038 para homens e 0,991 ± 0,025 para mulheres. Correlacionou-se então esta proporção às notas teóricas e práticas obtidas pelos estudantes durante os primeiros quatro semestres letivos do curso. As notas teóricas e práticas foram negativamente correlacionadas à proporção digital em homens (especialmente após a remoção da influência das horas de estudo domésticas; p = 0,02 e 0,004, respectivamente), mas não em mulheres (p = 0,89 e 0,77, respectivamente). Este achado apóia a correlação entre a influência da testosterona pré-natal e o desenvolvimento da inteligência em homens. A falta de correlação entre a testosterona pré-natal e o sucesso acadêmico em mulheres sugere que a inteligência no sexo feminino deve ser influenciada por fatores alheios à testosterona pré-natal
Abstract: It has been suggested that prenatal testosterone (PT) is positively related to intelligence or learning-ability skills. Digit ratio (2D:4D) is a negative correlate of PT. This study considered the correlations between 2D:4D and academic success in practical and theoretical disciplines in the Dental School curriculum of the Piracicaba Dental School, State University of Campinas, Brazil. Overall, 80 subjects (40 males and 40 females) aged between 18 and 22 years (means 19.5 ± 1.1 and 19.7 ± 1.2, respectively) had their right hand palm photographed by a digital camera attached to a standardising device, perpendicular to the surface. The images were transferred to a computer and the index and ring fingers were measured from the ventralmost crease up to the tip of the finger using Adobe Photoshop. Data were analyzed using Microsoft Excel and SPSS 16. Mean digit ratio was 0.980 ± 0.038 for males and 0.991 ± 0.025 for females. Digit ratio was correlated to the grades obtained by the students through their first four semesters. Theoretical and practical grades were significantly negatively correlated to digit ratio in males (and this was particularly so after the influence of age and hours of study were removed, p = 0.02 and 0.004, respectively), but not in females (p = 0.89 and 0.77, respectively). This finding supports a link between high PT and intelligence in males. The lack of relationship between 2D:4D and examination marks in female students, suggests that intelligence in females may be influenced by factors other than prenatal testosterone
Doutorado
Patologia
Doutor em Estomatopatologia
Silva, Elcio Dias 1951. "Goserelina versus leuprolide na castração química de pacientes com câncer prostático = Goserelin versus leuprolide in the chemical castration of patients with prostate cancer." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312273.
Full textTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Objetivo: avaliar a eficácia relativa do leuprolide 3,75 mg, leuprolide 7,5 mg e goserelina 3,6 mg quanto à redução da testosterona sérica, em níveis de castração. Método: foram avaliados 60 pacientes com carcinoma avançado de próstata, com indicação de bloqueio hormonal. Os pacientes foram divididos em 3 grupos de 20: Grupo 1) pacientes que receberam leuprolide na dose 3,75 mg; Grupo 2) receberam leuprolide 7,5 mg, Grupo 3) receberam goserelina 3,6 mg. Todos os grupos foram tratados por aplicação mensal das respectivas medicações. Os pacientes foram avaliados com dosagens de testosterona sérica em 2 momentos: pré-tratamento e após 3 meses de tratamento. Resultados: a idade dos pacientes foi semelhante nos três grupos, com mediana de 72, 70 e 70 anos, respectivamente aos grupos 1, 2 e 3. Dos pacientes que receberam leuprolide 3,75 mg, leuprolide 7,5 mg e goserelina 3,6 mg, 26,3%, 25% e 35%, respectivamente, não obtiveram nível de castração, considerando nível de corte de testosterona ? 50 ng/dl; e 68,4%, 30% e 45%, respectivamente, não obtiveram nível de castração, considerando nível de corte de testosterona ? 20 ng/dl. Conclusão: não houve diferença significativa na obtenção de níveis de castração com leuprolide 3,75 mg, leuprolide 7,5 mg e goserelina 3,6 mg, quando comparadas as três substâncias em conjunto. Quando comparados os grupos dois a dois, houve diferença estatisticamente significativa na análise do leuprolide 3,75 mg com o leuprolide 7,5 mg, havendo maior obtenção de nível de castração com 7,5 mg, quando se considera este nível como igual ou menor que 20 ng/dl. A importância dessa eventual diferença, no entanto, deve ser vista com cautela, já que a comparação dos três grupos simultaneamente, muito embora próximo, não atingiu o nível de significância estabelecido
Abstract: Purpose: to evaluate the relative efficiency of leuprolide 3.75 mg, leuprolide 7.5 mg, and goserelin 3.6 mg in relation to the reduction of serum testosterone, regarding the levels of castration. Methods: we evaluated prospectively 60 randomized patients with advanced prostate carcinoma, with indication for hormone blockade. The patients were divided into 3 groups of 20: Group 1) received leuprolide 3.75 mg; Group 2) received leuprolide 7.5 mg; group 3) received goserelin 3.6 mg. All groups were treated with monthly application of the respective drugs. Results: the patients' ages were similar within the three groups, with a median of 72, 70, and 70 in groups 1, 2, and 3, respectively. Of the patients that received leuprolide 3.75 mg, leuprolide 7.5 mg, and goserelin 3.6 mg, 26.3%, 25%, and 35%, respectively, did not reach castration levels, considering a testosterone cut of ?50 ng/dl. 68.4%, 30%, and 45%, respectively, did not reach castration levels, considering a testosterone cut of ?20 ng/dl. Conclusions: There were no statiscally significant differences in the levels of castration when comparing with leuprolide 3.75 mg, leuprolide 7.5 mg, and goserelin 3.6 mg, when comparing the three substances altogether. When compared in groups of two, there was a statiscally significant difference between leuprolide 3.75 mg and leuprolide 7.5 mg, in which the latter presented better results in reaching castration levels, when considered equal or less than 20ng/dl. The importance of this difference, however, must be measured with caution, since the comparison of the three groups simultaneously did not reach the established significance level, even though it came close
Doutorado
Fisiopatologia
Doutor em Ciências
Arruda, Ademir Felipe Schultz de. "Territorialidade e nível do adversário: efeitos nas respostas hormonais e comportamentais em jogadores de basquetebol." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/39/39134/tde-25062014-074945/.
Full textThe aim of this dissertation was to investigate the effect of territoriality and the level of opponent on hormonal and behavioral responses in basketball players. Two studies were conducted. In the first one, in order to investigate the effect of territoriality on hormonal and behavioral responses from official basketball matches, eighteen male players, from two under-19 teams (ranked matches in first and second place in the competition) were investigated. The teams played against each other, so each team performed a game \"at home\" and \"away from home\" game. Saliva samples were collected before and after the two matches for hormone analysis [testosterone (T) and cortisol (C)]. Before warm-up, a pre-competitive anxiety questionnaire was answered (Competitive State Anxiety Inventory-2, CSAI-2), and 30 minutes after the matches, the athletes classified the magnitude of effort by means of session-RPE. It was observed a higher value for T PRE game during \"at home\" condition when compared to \"away from home\"; there was a rise in T and C concentrations from moment PRE to POST in both conditions (\"at home\" and \"away\"); significant correlations were observed between hormonal and behavioral responses. These results show the occurrence of territoriality phenomenon, demonstrated by the higher T concentration during \"at home\" PRE game moment, and that official competitive condition is a stressor event capable of altering hormonal concentration. In the second study, the purpose was to verify the influence of the level of the opponent on hormonal and behavioral responses in basketball players. Twelve athletes from an under-19 team were evaluated in three different official matches and one training session (TS). Each official match was played against an opponent with different level of quality: weak match (WM), medium match (MM) and strong match (SM). The classification of the level of the opponent was made by a member of the coaching staff at the beginning of the competitive season and monitored in accordance with the position of the teams during the championship. Saliva samples were collected before and after the four conditions (three games and a training session) for T and C analyzing. Before warm-up, players answered the CSAI-2 questionnaire and approximately 30 minutes after the game, answered session-RPE. It was demonstrated an increase in T concentration from PRE to POST moments in response to TS and SM conditions and T concentration during PRE-SM was higher when compared to PRE-TS condition. The concentration of C increased from PRE to POST moments during TS, MM, and SM and C concentration during PRE and POST-SM were higher compared to the same moments for TS condition. Athletes reported higher values of somatic and cognitive anxieties in MM and SM when compared to WM condition. Self-confidence values were greater during TS compared to MM and SM. Session-RPE presented higher scores in MM and SM compared to TS. The results of the present investigation indicate that official games against opponents of different levels may promote hormonal and perceptual responses of distinct magnitudes
Shrestha, Swornim M. "Testosterone Reactivity to Skydiving." ScholarWorks@UNO, 2013. http://scholarworks.uno.edu/honors_theses/44.
Full textComas, Reixach Immaculada. "Estudi de la concentració de testosterona en pacients amb càncer de pròstata durant la supressió androgènica mitjançant diferents procediments de mesura." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/671073.
Full textLas guías clínicas del cáncer de próstata (CaP) recomiendan la medida de la concentración de testosterona para evaluar la eficacia de la castración y para diagnosticar la resistencia a la castración cuando se observa una progresión bioquímica o clínica. La respuesta a los análogos de la hormona liberadora de la hormona luteinizante (LH-RH) se considera eficaz cuando la concentración de testosterona se mantiene <50 ng/dL. Sin embargo, esta concentración llamada de castración fue definida en los años ochenta en pacientes sometidos a castración quirúrgica, siendo el límite inferior de sensibilidad del radioinmunoanálisis utilizados entonces. En el seguimiento de estos pacientes la concentración de testosterona es especialmente baja y es necesario utilizar procedimientos de medida exactos y reproducibles, para verificar la eficacia del tratamiento y poder definir la resistencia a la castración. Los inmunoanálisis han sido una herramienta fundamental para la medida de los esteroides sexuales. Sin embargo, los últimos años se ha demostrado que estos no tienen suficiente exactitud, precisión y reproducibilidad para medir concentraciones inferiores al límite inferior del intervalo de referencia. El desarrollo de procedimientos para la medida de la concentración de testosterona mediante técnicas de espectrometría de masas acoplada a técnicas de separación de cromatografía permite medir bajas concentraciones de testosterona con elevada sensibilidad y especificidad. Nuestra hipótesis inicial es que, en pacientes con CaP sometidos a castración médica, la medida de la testosterona con cromatografía líquida y detección por espectrometría de masas es más precisa que cuando se mide con los métodos de quimioluminiscencia para evaluar la eficacia del tratamiento y definir el estado de resistencia a la castración. Como hipótesis adicional nos hemos planteado que la medida de la concentración de LH es un método más específico para evaluar la actividad de la castración médica. Con la selección de pacientes y recogida prospectiva de datos entre los 2016 y 2018 se reclutaron 1510 pacientes con CaP en tratamiento con análogos de la LHRH y se seleccionó un grupo de pacientes control elegidos al azar de los hombres que tenían programada biopsia de próstata debido a la sospecha de CaP. En las bases de datos se recogieron datos referentes al diagnóstico y tratamiento, datos demográficos y resultados de diferentes pruebas analíticas: LH, FSH, testosterona, testosterona libre, PSA, SHBG y prolactina. Se hicieron diferentes subgrupos para estudiar la concentración de testosterona con diferentes procedimientos de medida y valorar su evolución al tratamiento. Se hicieron dos subgrupos de 249 y 143 pacientes respectivamente con resultado de testosterona medida con el equipo Advia Centaur®XP <100 ng/dL, y un subgrupo de 1091 pacientes con concentración de testosterona medida con el equipo Advia Centaur®XP < 150 ng/dL. Se seleccionaron 138 pacientes que presentaban concentración de LH <1,1 U/L. De las revisiones, comparaciones y valoraciones realizadas, se concluye que los diferentes métodos para medir la concentración de testosterona, los más utilizados son los que utilizan la quimioluminiscencia como principio de medida. El método de referencia para su medida en pacientes con CaP sometidos a supresión androgénica debe ser la LC-MSMS debido que los métodos quimioluminiscentes presentan diferencias de reproducibilidad, especificidad, sensibilidad y elevada variabilidad en concentraciones <50 ng/dL mientras que LC-MSMS presenta buenas características metrológicas. La concentración de castración con este método es <50 ng/dL. Y encontramos que la concentración de LH es mejor marcador que la testosterona para evaluar el correcto funcionamiento del tratamiento. Por lo tanto, proponemos la concentración de 1,1 U/L como concentración de castración y una concentración de LH de 0,12U/L la que nos permite diferenciar la castración óptima de la subóptima.
Prostate cancer (CaP) clinical guidelines recommend measuring testosterone concentration to evaluate the effectiveness of castration and detected observed. The response to luteinizing hormone-releasing hormone (LH-RH) analogs is considered effective when testosterone concentration is <50 ng/dL. However, this castration concentration was defined in the 1980s in patients undergoing surgical castration, a level established by using the lower limit of sensitivity of radioimmunoassay method. In these patients the testosterone concentration is especially low and it is necessary to use accurate and reproducible measurement procedures, to verify the effectiveness of the treatment and define the resistance to castration. Immunoassays have been a key tool in measuring sex steroids. However, several recent studies agree that these have low accuracy, precision and reproducibility to measure concentrations below the lower limit of the reference range. The development of procedures for the measurement of testosterone concentration using mass spectrometry techniques coupled with chromatography separation techniques allows us to measure low testosterone concentrations with high sensitivity and specificity. Our initial hypothesis is that in patients with CaP undergoing medical castration, the measurement of testosterone by liquid chromatography and detection by mass spectrometry is more accurate than when measured with chemiluminescence methods to evaluate adequate castration levels and define the state of resistance to castration. As an additional hypothesis, we have considered that the measurement of LH concentration is a more specific method for evaluating the activity of medical castration. With the selection of patients and prospective data collection between 2016 and 2018, 1510 patients with CaP in treatment with LHRH analogues were recruited and a group of randomly selected control patients from men who had scheduled biopsy of prostate to suspicion of CaP was selected. Data relating to diagnosis and treatment, demographic data, and results of different analytical tests were collected from the databases: LH, FSH, testosterone, free testosterone, PSA, SHBG, and prolactin. Different subgroups were made to study testosterone concentration with different measurement procedures and to assess its evolution to treatment. Two subgroups of 249 and 143 patients with testosterone results measured with the Advia Centaur®XP <100 ng/dL, and a subgroup of 1091 patients with testosterone levels measured with the Advia Centaur®XP <150 ng/dL were selected. 138 patients with a concentration of LH <1.1U/L were selected. From the reviews, comparisons and assessments performed, it is concluded that of the different methods for measuring testosterone, the most used useful are those that use chemiluminescence as a principle of measurement. The reference method for its measurement in patients with CaP undergoing castration should be LC-MSMS because chemiluminescent methods show differences in reproducibility, specificity, sensitivity and high variability at concentrations <50ng/dL while LC- MSMS presents good metrological characteristics. The castration concentration with this method is <50 ng/dL. Moreover, we find that LH concentration is more accurate than testosterone for assessing the LH-RH agonist efficacy. Therefore, we propose the concentration of 1.1 U/L as a castration concentration and an LH concentration of 0.12 U/L which allows us to differentiate the optimal castration from the suboptimal one.
Crespilho, Daniel Maciel [UNESP]. "Efeito do treinamento físico sobre aspectos metabólicos e endócrinos de ratos wistar administrados com testosterona." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/87464.
Full textSecretaria de Estado de Educação
Os objetivos do presente estudo foram investigar as adaptações endócrinometabólicas em ratos submetidos ao exercício físico de natação associado com a administração de testosterona durante 8 semanas. Ratos jovens Wistar foram divididos em 4 grupos: controle sedentário (CS), controle treinado (CT), testosterona sedentário (TS), testosterona treinado (TT). O protocolo de natação consistiu de 1 hora/dia, 5 dias/semanas, durante 8 semanas, suportando durante a natação uma sobrecarga de 5% do seu peso corporal. A testosterona foi administrada 3 dias/semana, na concentração de 5 mg/kg de peso corporal do animal, por via subcutânea, também por 8 semanas. Ao final da sétima semana de experimento, os ratos foram submetidos aos testes de tolerância à glicose (GTT) e teste de tolerância à insulina (ITT). Após 10 semanas os animais foram sacrificados na condição de repouso. Amostras de sangue foram coletadas para a determinação do hematócrito, glicose, insulina, proteínas totais, colesterol total e triglicérides. Os testículos, a próstata e vesícula seminal, os tecidos adiposos foram analisados em balança analítica. O tecido muscular e hepático foram usados para determinação do glicogênio e da razão proteína/DNA. As adrenais foram pesadas e usadas para determinar o conteúdo de colesterol e ácido ascórbico. A análise estatística foi feita por ANOVA e aplicação do teste de post-hoc de Newman-Keuls, onde adequado, com nível de significância pré-fixado em 5%. Os resultados indicam que os ratos treinados tiveram maior tolerância à glicose comparados com os animais sedentários durante o GTT. Nossos dados mostram que a administração crônica da testosterona mais o treinamento físico foi associada ao aumento da sensibilidade à insulina.O grupo treinado administrado com testosterona mostrou uma maior taxa de desaparecimento...
The aims of this study were to investigate the endocrine-metabolic adaptations in rats submitted to chronic swimming exercise associate to administration of testosterone during 8 weeks. Young Wistar rats were divided into four groups: sedentary control (CS), trained control (CT), sedentary testosterone (TS), trained testosterone (TT). Training protocol consisted of swimming 1h/day, 5 days/week, during 8 weeks, supporting a load of 5% body weight. Testosterone was administered 3 times a week, in concentration of 5 mg/kg body weight, during 8 weeks. After 7 weeks rats were submitted to glucose (GTT) and insulin (ITT) tolerance tests. After 8 weeks rats were sacrificed in rest. Blood samples were collected to determine hematocrit, glucose, insulin, total protein, total cholesterol and triglyceride. Hepatic and muscular tissues were used to determine glycogen and protein/DNA ratio. Adrenals were weighed and used to determine cholesterol and ascorbic acid contents. The results were analyzed by ANOVA and Newman- Keuls post-hoc test where appropriate and the significance level was 5%. The results indicate that trained rats showed higher glucose tolerance compared to sedentary animals during GTT. Our data showed that chronic exposure to testosterone plus physical training was associated with increase insulin sensitivity. The animals trained and administered with testosterone, showed higher glucose disappearance rates when compared to other groups. Testosterone administration promoted decrease in testicular mass and increase in prostate and seminal vesicle. Training promoted increase in muscle when compared to the sedentary groups, taking us to presuppose that training stimulated glycogen syntheses. The training protocol, testosterone administration or combination of two treatments, resulted in decrease of epididimal and perirrenal adipose tissues weight... (Complete abstract click electronic access below)
English, Katherine M. "The cardiovascular effects of testosterone." Thesis, University of Sheffield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340222.
Full textKnickmeyer, Rebecca. "Foetal testosterone and developmental disorders." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440618.
Full textCardinale, Marco, and Michael H. Stone. "Is Testosterone Influencing Explosive Performance?" Digital Commons @ East Tennessee State University, 2006. https://dc.etsu.edu/etsu-works/4614.
Full textCampos, Mônica Sousa. "Análise morfológica, imuno-histoquímica e ultraestrutural dos efeitos da exposição ao flavonóide crisina sobre a próstata de gerbilos adultos." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/154131.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
A crisina é um composto natural biologicamente ativo encontrado predominantemente em flores de maracujá azul, em mel, camomila, própolis e casca de frutas. Possui propriedades potentes como efeito anti-inflamatório, antioxidante e tem sido empregada para o tratamento de desordens reprodutivas. Essa flavona tem o potencial de aumentar os níveis de testosterona endógena, tanto por inibir a enzima aromatase, quanto por estimular a esteroidogênese testicular. Alterações no metabolismo hormonal mediadas por interferências exógenas podem interferir na fisiologia prostática resultando em modificações na atividade secretora da glândula e na regulação dos receptores hormonais. Assim, o objetivo deste estudo foi avaliar os efeitos da exposição à crisina sobre a próstata e gônadas de gerbilos adultos. Para avaliar o potencial androgênico da crisina, nós analisamos, comparativamente, os efeitos da testosterona sobre estes mesmos órgãos. Machos e fêmeas de gerbilos com 90 dias de idade foram tratados com crisina (50 mg/kg/dia) ou com cipionato de testosterona (1 mg/kg/semana) e divididos tem 3 subgrupos que foram eutanasiados após 3, 7 e 21 dias de tratamento. As próstatas foram coletadas para análises morfológicas, morfométrico-estereológicas, imuno-histoquímicas e ultraestruturais. Testículos e ovários foram submetidos a análises morfológicas e morfométrico-estereológicas. Os níveis séricos de testosterona e 17β-estradiol foram mensurados por ELISA. Machos e fêmeas tratados com crisina não apresentaram aumento dos níveis séricos de testosterona. No entanto, apenas as fêmeas tratadas com crisina durante 21 dias demonstraram aumento nos níveis séricos de estradiol. Foram observados tanto na próstata ventral masculina, quanto na próstata feminina em todos os tempos de tratamento com crisina, aumento da frequência de receptores androgênicos (AR), maior taxa de proliferação e hiperplasia glandular. Além disso, foi observada nas fêmeas em todos os tempos de exposição com crisina maior frequência imunomarcação para receptor estrogênico alfa (ERα). Ultraestruturalmente, machos e fêmeas tratados com crisina apresentaram intenso desenvolvimento das organelas da rota biossintética-secretora, acompanhada de intensa remodelação estromal, enquanto toxicidade celular foi observada apenas nas fêmeas. Nas gônadas masculinas o tratamento com crisina preservou a morfologia testicular. Em fêmeas, observou-se um maior número de folículos ovarianos em maturação. Comparativamente o tratamento com cipionato de testosterona foi capaz de causar lesões na próstata e gônadas, visto que focos de neoplasia intraepitelial prostática e degeneração gonadal foram observados em ambos os sexos. Esses resultados demonstram que a exposição à crisina, preservou a morfologia testicular normal, aumentou o número de folículos ovarianos em crescimento, aumentou a atividade secretória e alterou a regulação de receptores hormonais na próstata, potencializando a resposta desta glândula aos efeitos biológicos dos esteróides endógenos. Assim nas condições experimentais desse estudo embora a crisina e a testosterona evocassem alterações morfológicas semelhantes na próstata gerbilos masculina e feminina, a suplementação com crisina foi mais favorável à saúde da próstata. Contudo, a administração de crisina como agente fitoterápico deve ser considerada com precaução, visto que esse flavonóide parece exercer efeitos diferenciais em machos e fêmeas.
Chrysin is a naturally occurring biologically active compound found predominantly in blue passion flower, honey, chamomile, propolis and fruit peel. It has potent anti-inflammatory and antioxidant properties and has been used for the treatment of reproductive disorders. This flavone has the potential to increase endogenous testosterone levels both by inhibiting the aromatase enzyme and stimulating testicular steroidogenesis. Changes in hormone metabolism mediated by exogenous interferences may interfere with the prostatic physiology resulting in changes in the secretory activity of the gland and in the regulation of hormonal receptors. Thus, the objective of this study was to evaluate the effects of the exposure to chrysin on the prostate and gonads of adult gerbils. To evaluate the androgenic potential of chrysin, we comparatively analysed the effects of testosterone on these organs. Male and female gerbils aged 90 days were treated with either chrysin (50 mg/kg/day) or testosterone cypionate (1 mg/kg/week), subdivided into 3 subgroups and euthanized after 3, 7 and 21 days of treatment. The prostates and gonads were collected for morphological, morphometric-stereological, ultrastructural and immunehistochemical analyses. The testes and ovaries were subjected to morphological and morphometric-stereological analyses. Serum levels of testosterone and 17β-estradiol were determined using ELISA methods. Males and females treated with chrysin did not show increase in serum testosterone levels. However, only the females treated with chrysin for 21 days showed increase in the serum levels of estradiol. It was observed in both ventral prostate of males and in prostate of females in all the times of treatment with chrysin an increase in the frequency of androgen receptors (AR), a higher rate of proliferation and glandular hyperplasia. In addition, it was observed in all exposure times of females treated with chrysin a higher immunoreactivity frequency for alpha estrogen receptor (ERα). As to ultrastructure, males and females treated with chrysin showed intense development of the organelles of the biosynthetic-secretory route, accompanied by intense stromal remodeling. Cell toxicity was observed only in females. In the gonads of males the treatment with chrysin preserved testicular morphology. In females, we observed a larger number of ovarian follicles in maturation. Comparatively, the treatment with testosterone cypionate was able to cause lesions in the prostate and gonads, since the foci of prostatic intraepithelial neoplasia and gonadal degeneration were observed in both sexes. These results demonstrate that exposure to chrysin preserved normal testicular morphology, increased the number of ovarian follicles in growth, higher activity of secretory and changed the regulation of hormone receptors in the prostate potentiating the response of this gland to the biological effects of endogenous steroids. Therefore, under the experimental conditions of this study, although the chrysin and testosterone evoked similar morphological changes to those in the prostate of both sexes, supplementation with chrysin appeared to be more favorable to the prostate health. However, the chrysin intake as a phytotherapic agent should be considered with caution given that this flavonoid seems to exert distinct effects in males and females.
Books on the topic "Testosterone"
Nieschlag, Eberhard, Hermann M. Behre, and Susan Nieschlag, eds. Testosterone. Cambridge: Cambridge University Press, 2012. http://dx.doi.org/10.1017/cbo9781139003353.
Full textNieschlag, Eberhard, and Hermann M. Behre, eds. Testosterone. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-00814-0.
Full textHohl, Alexandre, ed. Testosterone. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-46086-4.
Full textNieschlag, Eberhard, and Hermann M. Behre, eds. Testosterone. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-72185-4.
Full textBaker, James Robert. Testosterone. Los Angeles: Alyson Books, 2000.
Find full textHohl, Alexandre, ed. Testosterone. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-31501-5.
Full textByron, Christopher M. Testosterone Inc. New York: John Wiley & Sons, Ltd., 2004.
Find full textMorgentaler, Abraham. Testosterone for Life. New York: McGraw-Hill, 2008.
Find full text1954-, Jones T. Hugh, ed. Testosterone deficiency in men. Oxford: Oxford University Press, 2008.
Find full textMulhall, John P., Mario Maggi, and Landon Trost, eds. Controversies in Testosterone Deficiency. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-77111-9.
Full textBook chapters on the topic "Testosterone"
Rommerts, Focko F. G. "Testosterone: an overview of biosynthesis, transport, metabolism and action." In Testosterone, 1–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-00814-0_1.
Full textGooren, Louis J. G., and Kaas H. Polderman. "Safety aspects of androgen therapy." In Testosterone, 182–203. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-00814-0_10.
Full textFinkelstein, Joel S., and Anne Klibanski. "Effects of androgens on bone metabolism." In Testosterone, 204–18. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-00814-0_11.
Full textKrieg, Michael, and Sabine Tunn. "Androgens and human benign prostatic hyperplasia (BPH)." In Testosterone, 219–44. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-00814-0_12.
Full textSchröder, Fritz H. "Androgens and carcinoma of the prostate." In Testosterone, 245–60. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-00814-0_13.
Full textVermeulen, Alex. "Androgens and male senescence." In Testosterone, 261–76. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-00814-0_14.
Full textWeinbauer, Gerhard F., and Eberhard Nieschlag. "The role of testosterone in spermatogenesis." In Testosterone, 23–50. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-00814-0_2.
Full textHubert, Walter. "Psychotropic effects of testosterone." In Testosterone, 51–71. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-00814-0_3.
Full textSchweikert, Hans-Udo, and Gabriela Romalo. "Syndromes caused by androgen resistance." In Testosterone, 72–91. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-00814-0_4.
Full textNieschlag, Eberhard, and Hermann M. Behre. "Pharmacology and clinical uses of testosterone." In Testosterone, 92–114. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-00814-0_5.
Full textConference papers on the topic "Testosterone"
Murphy, Adam B., Yaw Nyame, Brian Kelley, Chiledum A. Ahaghotu, and Rick A. Kittles. "Abstract A93: Correlates of total testosterone and testosterone deficiency in African American men." In Abstracts: AACR International Conference on the Science of Cancer Health Disparities‐‐ Sep 18-Sep 21, 2011; Washington, DC. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1055-9965.disp-11-a93.
Full textMakiko, Aoki, Satoshi Suzuki, and Ryouma Anzai. "Relationship between activation of prefrontal cortex and testosterone in N-back task." In 13th International Conference on Applied Human Factors and Ergonomics (AHFE 2022). AHFE International, 2022. http://dx.doi.org/10.54941/ahfe1001830.
Full text"Effects of Testosterone on Pain Threshold." In International Conference on Chemical, Agricultural and Medical Sciences. International Institute of Chemical, Biological & Environmental Engineering, 2014. http://dx.doi.org/10.15242/iicbe.c514067.
Full text"The Effects of Testosterone on Lipid Profile." In Eminent Association of Pioneers. Eminent Association of Pioneers (EAP), 2016. http://dx.doi.org/10.17758/eap.eap816241.
Full textDias, Jerry, and Hongwu Gao. "Synthetic Studies Toward 1a-Hydroxytestosterone from Testosterone." In The 4th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01880.
Full textSampaio Mangolim, Amanda, Leonardo de Andrade Rodrigues Brito, and Vania dos Santos Nunes Nogueira. "EFFECTIVENESS OF TESTOSTERONE REPLACEMENT IN OBESE MEN WITH LOW TESTOSTERONE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED TRIALS." In ANAIS ONLINE DO "HEALTH TECHNOLOGY RESEARCH IN BRAZIL: CHALLENGES FOR THE NEW DECADE". Galoa, 2021. http://dx.doi.org/10.17648/htbr-2021-125103.
Full textMa, Rui, and Tian C. Zhang. "Sorption and Desorption of Testosterone in Agricultural Soils." In World Environmental and Water Resources Congress 2009. Reston, VA: American Society of Civil Engineers, 2009. http://dx.doi.org/10.1061/41036(342)268.
Full textSommer, Bettina, Edgar Flores-Soto, Jorge Reyes-García, Verónica Díaz-Hernández, Abril Carbajal-García, and Luis M. Montaño-Ramírez. "Testosterone concentration-dependent effects on airway smooth muscle." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa4069.
Full textDomoshnitsky, Alexander, Irina Volinsky, and Olga Pinhasov. "Some developments in the model of testosterone regulation." In RENEWABLE ENERGY SOURCES AND TECHNOLOGIES. AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5127475.
Full textSivacoumar, R., M. Vinoth, and Zachariah C. Alex. "P1.1.3 Tapered Optical Fiber BioSensor for Testosterone Detection." In 14th International Meeting on Chemical Sensors - IMCS 2012. AMA Service GmbH, Von-Münchhausen-Str. 49, 31515 Wunstorf, Germany, 2012. http://dx.doi.org/10.5162/imcs2012/p1.1.3.
Full textReports on the topic "Testosterone"
Kirby, Michael, and Jonny Coxon. The metabolic syndrome, erectile dysfunction and testosterone deficiency. BJUI Knowledge, September 2019. http://dx.doi.org/10.18591/bjuik.0484.
Full textEibich, Peter, Ricky Kanabar, Alexander Plum, and Julian Schmied. In and out of unemployment - labour market dynamics and the role of testosterone. Rostock: Max Planck Institute for Demographic Research, September 2020. http://dx.doi.org/10.4054/mpidr-wp-2020-033.
Full textLu, Jiyuan, Lingdan Xu, Yanduo Yang, Yucheng Meng, Yi Li, Huihui Wang, and Bin Liu. Obstructive sleep apnea and serum total testosterone: a system review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0110.
Full textRedmond, Lucas. The Biology of Eastern Kingbirds at Malheur National Wildlife Refuge: Survival, Reproduction, and Testosterone Secretion. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.2618.
Full textGuo, Bin, Jiao-jiao Liu, and Jian-guo Liu. Efficacy of tamoxifen in combination with low dose testosterone undecanoate in the treatment of idiopathic male infertility: a meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2021. http://dx.doi.org/10.37766/inplasy2021.4.0068.
Full textEl Halawani, Mohamed, and Israel Rozenboim. Environmental factors affecting the decline in reproductive efficiency of turkey hens: Mediation by vasoactive intestinal peptide. United States Department of Agriculture, January 2007. http://dx.doi.org/10.32747/2007.7696508.bard.
Full textYaron, Zvi, Martin P. Schreibman, Abigail Elizur, and Yonathan Zohar. Advancing Puberty in the Black Carp (Mylopharyngodon Piceus) and the Striped Bass (Morone Saxatilis). United States Department of Agriculture, August 1993. http://dx.doi.org/10.32747/1993.7568102.bard.
Full textYaron, Zvi, Abigail Elizur, Martin Schreibman, and Yonathan Zohar. Advancing Puberty in the Black Carp (Mylopharyngodon piceus) and the Striped Bass (Morone saxatilis). United States Department of Agriculture, January 2000. http://dx.doi.org/10.32747/2000.7695841.bard.
Full textIndications and contraindications for testosterone replacement therapy. BJUI Knowledge, February 2018. http://dx.doi.org/10.18591/bjuik.0496.
Full textHow Testosterone Leads to Overpricing on Wall Street. IEDP Ideas for Leaders, May 2016. http://dx.doi.org/10.13007/608.
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