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Academic literature on the topic 'TESTICULAR GERM CELL TUMOR'

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Published: 10 March 2023

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Journal articles on the topic "TESTICULAR GERM CELL TUMOR"

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Islam, Sardar. "Metastatic Mixed Germ Cell Tumor Presented With Hemoptysis- A Case Report." Journal of Surgical Case Reports and Images 3, no. 1 (January 4, 2020): 01–03. http://dx.doi.org/10.31579/2690-1897/017.

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A 35 year’s old male presented with right testicular swelling for last six month. He developed hemoptysis and mild dyspnea for 2 weeks. Ultrasonography revealed testicular malignancy with multiple heterogenecity. CT scan of the abdomen did not reveal any lymph node metastasis. His X-ray chest showed extensive pulmonary metastasis. All three tumor markers were raised. Histology was suggestive of mixed germ cell tumor with a rare combination of Seminoma and Choriocarcinoma. Because of this rare combination of 2 varieties of testicular germ cell tumor and advanced systemic metastasis we presented this case.
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Chieffi, Paolo, Marco De Martino, and Francesco Esposito. "New Anti-Cancer Strategies in Testicular Germ Cell Tumors." Recent Patents on Anti-Cancer Drug Discovery 14, no. 1 (March 13, 2019): 53–59. http://dx.doi.org/10.2174/1574892814666190111120023.

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Background: The most common solid malignancy of young men aged 20 to 34 years is testicular germ cell tumor. In addition, the incidence of these tumors has significantly increased throughout the last years. Testicular germ cell tumors are classified into seminoma and nonseminoma germ cell tumors, which take in yolk sac tumor, embryonal cell carcinoma, choriocarcinoma, and teratoma. There are noteworthy differences about therapy and prognosis of seminomas and nonseminoma germ cell tumors, even though both share characteristics of the primordial germ cells. </P><P> Objectives: The study is focused on different molecular mechanisms strongly involved in testicular germ cell line tumors underlying new strategies to treat this human neoplasia.Methods:Bibliographic data from peer-reviewed research, patent and clinical trial literature, and around eighty papers and patents have been included in this review.Results:Our study reveals that several biomarkers are usefully utilized to discriminate among different histotypes. Moreover, we found new patents regarding testicular germ cell tumor treatments such as the expression of claudin 6, monoclonal antibody (Brentuximab Vedotin), immune checkpoint blockade (ICB) with the FDA-approved drugs pembrolizumab and nivolumab or the oncolytic virus Pelareorep, the combination of selective inhibitors of Aurora kinase.Conclusion:Finally, the pathogenesis of testicular germ cell tumor needs to be deeply understood so that it will improve data on stem cells, tumorigenesis and disease tumor management by more selective treatment.
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Iqbal, Jawed, Shahnaz Imdad Kehar, Nazish Jaffer, and Farah Asad. "Frequency and morphological study of testicular germ cell tumor." Professional Medical Journal 26, no. 10 (October 10, 2019): 1794–98. http://dx.doi.org/10.29309/tpmj/2019.26.10.4144.

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Objectives: To assess the frequency of various histopathological types of testicular germ cell tumor in our study population. The prime identification of testicular germ cell tumor is important to prevent the advance stage of cancers. The present study was design to assess the frequency of different morphological types of testicular germ cell tumor which have a mirror effect on the treatment and prognosis of tumor. Study Design: Cross sectional study. Setting: Department of pathology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre Karachi. Period: 10 years period from 1st January 2006 to 31st December 2015. Material and Methods: A 34 cases of testicular germ cell tumor were studied for morphological features using all properly formalin fixed, paraffin embedded surgical pathological testicular specimens received during the above period. All relevant clinical information was recorded on designed proformas. Section were taken and stained with hematoxylin and eosin. Data entered and analysed through computer software SPSS version 21. Results: The result of study showed that the frequency of testicular germ cell tumor was 0.80% among all malignancy in male. Out of 36 cases of testicular tumor, 34 (94.5%) were germ cell tumors and remaining 02 (5.5%) cases were sex cord stromal tumor. Among 34 cases of germ cell tumor 12 (35.2%) cases of mixed germ cell tumor found which was the most common between them, followed by seminoma 10 (29.4%) cases. However 05(14.7%) of yolk sac tumor, 04 (11.6%) of teratoma and 03(8.8%) of embryonal tumor were found. Conclusion: Results revealed that frequency of different types of testicular germ cell tumor in this study were in accordance to national and international studies. However the incidence of tumor varies noticeably in different geographical areas. Different pattern of seminomas and non – seminomas also may be emerging.
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Woldu, Solomon L., James F. Amatruda, and Aditya Bagrodia. "Testicular germ cell tumor genomics." Current Opinion in Urology 27, no. 1 (January 2017): 41–47. http://dx.doi.org/10.1097/mou.0000000000000347.

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Javed, Muhammad Sheraz, Muhammad Irfan Munir, and Muhammad Saad Siddique. "PURE YOLK CELL TESTICULAR TUMOR;." Professional Medical Journal 24, no. 04 (April 6, 2017): 637–38. http://dx.doi.org/10.29309/tpmj/2017.24.04.1534.

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Background: Testicular tumor primarily originate from germ cells and are foundin all age groups. Among germ cell tumors one is pure yolk cell tumor which is tumor of infantand pediatric age group and is extremely rare in adulthood. Case Presentation: Current titledcase report is about a 23 year old male who presented with painless enlargement of righttestis. Examination revealed as hard lump involving right testis and clinically epididymis spared.Hormonal assessment consistent with malignant lesion of testis. Right inguinal approachedorchidectomy done and histopathology revealed it as pure yolk sac tumor of testis. Conclusion:Pure yolk cell tumor in adulthood is a very rare tumor and once diagnosed, need follow up inpost-operative circumstances.
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Miacola, Carlos, Ottavio Colamonico, Carlo Bettocchi, Vito Ricapito, Silvano Palazzo, Marcello Campagna, Michele Battaglia, and Pasquale Martino. "Burned-out in a mixed germ cell tumor of the testis: The problem of pT0. Case report." Archivio Italiano di Urologia e Andrologia 86, no. 4 (December 30, 2014): 389. http://dx.doi.org/10.4081/aiua.2014.4.389.

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Germ cell tumors constitute the majority of all testicular tumors, which are relatively rare overall and are mainly encountered in young adults and teenagers. The term ‘burned-out’ germ cell tumor refers to the presence of a metastatic germ cell tumor with histological regression of the primary testicular lesion. Clinical examination of the testes and scrotal sonography is the initial diagnosis of such neoplasms. We report an unusual case of a burned-out testicular tumor with metastases to retroperitoneal lymphnodes in an asymptomatic patient with right testicular hypoechoic nodule associated with multiple calcifications of the testicular parenchyma.
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Damjanov, Ivan. "Testicular Germ Cell Tumors: Serological and Immunohistochemical Diagnosis." Acta Medica Academica 50, no. 1 (May 26, 2021): 58. http://dx.doi.org/10.5644/ama2006-124.326.

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<p>This review deals with serologic and immunohistochemical tumor markers used in clinical laboratories for the diagnosis of testicular germ cell tumors. Time tested serologic markers such as alpha-fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase are routinely used in the work-up of patients with testicular tumors. Professional organizations regulating the practice of medicine in most countries worldwide require that the laboratory values for these serologic reactants be included in the pathology reports on testicular tumors as part of the tumor staging process. Immunohistochemical markers of testicular germ have been identified and widely tested during the first two decades of the XXI century. We have selected the most useful immunohistochemical markers from a few of these markers and discussed them in this review.</p><p><strong>Conclusion</strong>. Published data show that testicular tumor markers are widely used in routine practice. The study of tumor markers has improved the pathologic and clinical diagnosis of testicular germ cell tumors and has thus contributed to their treatment.</p>
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Curreri, Stephanie A., Sarah C. Markt, Rowan Miller, Elizabeth O'Donnell, Brandon David Bernard, Sophia C. Kamran, Laurence Albiges, Alexi A. Wright, Christopher Sweeney, and Clair Beard. "Bilateral testicular germ cell tumors." Journal of Clinical Oncology 33, no. 7_suppl (March 1, 2015): 392. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.392.

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392 Background: Germ cell tumors (GCTs), both seminomatous and non-seminomatous, account for greater than 90% of testicular cancers. While bilateral testicular GCTs are rare, the incidence of bilateral tumors has increased over time. Methods: 668 cases of bilateral and 38,593 cases of unilateral testicular GCTs were reported between 1973 and 2011 by the SEER database. Patient characteristics and tumor features were analyzed. Results: The incidence of bilateral GCTs among men with testicular GCTs was 1.7% (668 of 39,261 total cases). Among the 668 men with bilateral GCTs, 53% (n=353) of second GCTs occurred within three years after the first cancer. 29% (n=196) of bilateral tumors occurred synchronously. Among patients with bilateral GCTs, 378 first GCTs and 466 second GCTs were seminomatous. 43% of bilateral cases were concordant seminomatous GCTs, 16% were concordant non-seminomas, and 41% were discordant histologies. 68% of unilateral GCTs, 70% of first GCTs, and 82% of second GCTs were staged as Localized disease. Testicular cancer was the cause of death for 4% (n=1,630) of men with a unilateral GCT and 1% (n=8) of men with bilateral GCTs. A second malignant neoplasm (SMN) was the cause of death for 2% (n=736) of men with a unilateral GCT and 2% (n=16) of men with bilateral GCTs. Conclusions: Among men with bilateral testicular GCTs, 59% had concordant histological diagnoses between their first and second tumor. Most (53%) second cancers among men with bilateral tumors occurred within three years after diagnosis of first cancers. Men who experience bilateral testicular GCTs do not appear to have an increased risk of death due to testicular cancer or a subsequent non-germ cell malignant neoplasm compared to men with a unilateral testicular GCT. [Table: see text]
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Kojo, Kosuke, Koji Kawai, Takashi Kawahara, Tomokazu Kimura, Shuya Kandori, Yoshiyuki Nagumo, Satoshi Nitta, et al. "Recent malignant testicular tumor trend in Japan, a country with an aging population: a large-scale study of 2012–2015 hospital-based cancer registry data." Japanese Journal of Clinical Oncology 50, no. 10 (July 6, 2020): 1201–8. http://dx.doi.org/10.1093/jjco/hyaa110.

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Abstract Objective Japan’s national database of hospital-based cancer registries is estimated to cover ~67% of all new cancer cases. Using this database, we analyzed the characteristics of the recently diagnosed testicular malignancy. Methods We obtained data for 6510 adult testicular malignancy patients diagnosed in 2012–2015. The distributions of patient ages, histological diagnoses and testicular germ cell tumor hospital care volumes were determined. Results The most common histology was seminoma (60.3% of all testicular malignancies), followed by non-seminoma (24.1%) and diffuse large B-cell lymphoma (13.1%). The median and mean ages of the testicular germ cell tumor patients were high at 38 and 39.8 years, respectively. The age distribution peaked at 30–40 years, followed by 40–50 years. Approximately 18% of testicular germ cell tumor patients were ≥50 years. The ages of the diffuse large B-cell lymphoma patients peaked at 70–80 years (mean 67.7 years). When the analysis was limited to the testicular germ cell tumor patients who received first-course cancer treatment at the participating hospitals, the number of high-volume hospitals with ≥20 testicular germ cell tumor care volume was limited to 61 (10.0% of the 605 hospitals that treated ≥1 testicular germ cell tumor patient). However, when the patients who changed hospitals during treatment or relapsed after treatment completion were analyzed together, the number of high-volume hospitals increased to 104 (17.0% of 612 hospitals). Conclusion The testicular germ cell tumor patients’ mean age was nearly 40 years. The proportions of older testicular germ cell tumor patients and diffuse large B-cell lymphoma patients were higher than previously thought. The reasons for this trend are unknown, but it is important to address the trend identified herein in a country with a super-aging population.
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González Quintela, A. (a), E. (b) Lόpez Bonet, J. (a) Román, and P. (a) Aramburo. "Testicular Germ Cell Tumor Seven Years after a Retroperitoneal Germ Cell Tumor." European Urology 19, no. 4 (1991): 336–38. http://dx.doi.org/10.1159/000473655.

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Dissertations / Theses on the topic "TESTICULAR GERM CELL TUMOR"

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Anderson, Philip D. "Genetic control of testicular germ cell tumor susceptibility in mice." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1247182449.

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Gels, Maria Elisabeth. "Testicular germ cell tumors developments in surgery and follow-up /." [Groningen] : [Groningen] : Rijksuniversiteit Groningen ; [University Library Groningen] [Host], 1997. http://irs.ub.rug.nl/ppn/15817464X.

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Mitchell, Roderick T. "Germ cell development in the human and marmoset fetal testis and the origins of testicular germ cell tumours." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4818.

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Normal germ cell development in the human testis is crucial for subsequent fertility and reproductive health. Disruption of testis development in fetal life can result in deleterious health consequences such as testicular dysgenesis syndrome (TDS), which includes disorders, such as cryptorchidism, hypospadias, infertility and testicular germ cell tumours (TGCT). A rat model of TDS in which rats are exposed to phthalates in utero has been validated, but does result in the development of TGCT. In humans, TGCTs result from transformation of pre-neoplastic carcinoma in-situ (CIS) cells and these CIS cells are believed to arise from human fetal germ cells during their transition from gonocyte to spermatogonia, based on their morphology and protein expression profile. It has been proposed asynchronous differentiation of germ cells in the human fetal testis may predispose fetal germ cells to become CIS cells. Studying the development of these tumours in humans is difficult because of their fetal origins and prolonged duration from initiation of impaired development to invasive disease. For this reason the use of relevant animal models that can mimic normal and abnormal germ cell development may provide new insight into how TGCT develop. The Common Marmoset monkey, a New World primate exhibits many similarities to the human in terms of reproductive biology and could represent such a model. This thesis aimed to further characterise the origins of CIS cells in the human testis by investigating the protein expression profile of CIS cells in patients with TGCT and comparing them to established markers of human fetal germ cell types using immunohistochemistry and immunofluorescence. Quantification of the various subpopulations of CIS and proliferation within these populations was performed. The thesis also investigated the Common Marmoset monkey as a potential model of normal testis and germ cell development by comparing the differentiation and proliferation profile of germ cells with those of the human during fetal and early postnatal life. During the present studies methods were successfully developed that enabled us to use testicular xenografts to recapitulate normal development of immature testes from marmoset and human. This involved grafting pieces of testis tissue subcutaneously under the dorsal skin of immunodeficient mice and retrieving them several weeks later to investigate their development during the grafting period. Xenografts using tissue from fetal, neonatal and juvenile marmosets were performed in addition to testes from first and second trimester human fetuses. Finally the present studies aimed to use the marmoset and the xenografting approach as systems in which to examine the effects of gonadotrophin suppression and phthalate treatment on germ cell differentiation and proliferation, with particular attention to the potential for development of CIS and TGCT. Heterogeneous phenotypes of CIS cells were identified, mostly consistent with those seen in the normal human fetal testis, however some of these CIS cells did not exhibit the same phenotype as germ cells identified in normal fetal testes. In addition it was shown that some of the proteins considered to be ‘classical’ markers of CIS cells, such as the pluripotent transcription factor OCT4, were not expressed in a proportion of the CIS cells. The proliferation index of CIS cells is also significantly higher in those subpopulations with the most ‘undifferentiated’ phenotype (i.e. OCT4+/VASA-). The present studies have generated novel data showing that the marmoset is a good model of fetal and neonatal germ cell development, with similarities to the human in terms of an asynchronous and prolonged period of differentiation and proliferation of germ cells from gonocyte to spermatogonia. This feature is also common to the human, but not a characteristic of the rodent. Fetal, neonatal and pre-pubertal germ cell development can be re-capitulated by xenografting tissue from marmoset and human testes into nude mouse hosts. Human fetal testis grafts produced testosterone and were responsive to hCG stimulation. First trimester human testis xenografts that have not developed fully formed seminiferous cords prior to grafting can complete the process of cord formation whilst grafted in host mice. In addition, germ cells in fetal human and marmoset xenografts can differentiate and proliferate in a similar manner to that seen in the intact non-grafted testis. In the intact neonatal marmoset, suppression of gonadotrophins resulted in a 30% decrease in proliferation, however differentiation of gonocytes is not affected. In-utero treatment of neonatal marmosets with mono-n-butyl phthalate was associated with unusual ‘gonocyte’ clusters, however, di-n-butyl phthalate treatment of mice carrying fetal marmoset xenografts resulted in no visible effects on germ cell differentiation or proliferation and did not result in the development of CIS or TGCT. In conclusion, this thesis has shown that there are many subpopulations of CIS cells of which many have not been previously described. These subpopulations have different characteristics, such as variable proliferation rates and this may indicate the potential for progression or invasiveness. These subpopulations have similar protein expression phenotypes to normal human fetal germ cells although the present studies have identified some CIS cells with phenotypes that are not found in the normal human testis. This thesis has demonstrated that the marmoset is a comparable model to the human in terms of asynchronous fetal germ cell development, which may predispose this species to the development of CIS/TGCT. In addition to the use of intact marmosets, these studies have also demonstrated for the first time that testis xenografting provides a comparable system for testis cord formation, germ cell differentiation and proliferation in fetal/postnatal marmosets and fetal human testis. In addition the marmoset and xenografting models have indicated that phthalates may have minor effects on testis development in the human and marmoset but do not result in CIS or TGCT. These model systems are suitable for further investigation of normal and disrupted testis development.
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Nastaly, Paulina [Verfasser], and Klaus [Akademischer Betreuer] Pantel. "Detection and characterization of circulating tumor cells in patients with testicular germ cell tumors and prostate cancer / Paulina Nastaly. Betreuer: Klaus Pantel." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2014. http://d-nb.info/1059237822/34.

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Fung, Ka-lai, and 馮家禮. "Significance of MAD2 in mitotic checkpoint control and cisplatin sensitivity of testicular germ cell tumour cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39357727.

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Fung, Ka-lai. "Significance of MAD2 in mitotic checkpoint control and cisplatin sensitivity of testicular germ cell tumour cells." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38588912.

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Quevedo, Francisco Carlos [UNESP]. "Tumores testiculares germinativos não-seminomas: imunoexpressão protéica de EGFR, Her2 E c-Kit." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/151631.

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As neoplasias testiculares constituem aproximadamente 1% dos cânceres masculinos. Dentre eles, os tumores que têm origem nas células germinativas (TTCG) são os mais frequentes. Por sua natureza, esses tumores têm padrão morfológico variado, sendo distribuídos em dois subgrupos: os seminomas e os não-seminomas. Esses últimos, por sua vez, são classificados em carcinomas embrionários, tumores do seio endodérmico, coriocarcinomas, teratomas e tumores mistos de células germinativas. Há consenso na literatura de que a invasão vascular verificada histologicamente no tumor primário é o melhor indicador preditivo de progressão da doença e recidiva. Estudos recentes demonstram o papel dos fatores de crescimento e seus receptores para avaliação prognóstica dos TTCG, no que o uso da imuno-histoquímica é fundamental. O presente estudo procurou avaliar pela técnica imuno-histoquímica à ocorrência da expressão do receptor do fator de crescimento epidérmico (EGFR), do Her2 e do c-Kit em uma série de TTCG não-seminomas primários de testículo. Além disso, explorou a possível relação entre a expressão desses marcadores com a evolução dos pacientes após terapêutica convencional. A série foi constituída de amostras parafinadas existentes no Laboratório de Anatomia Patológica e Citologia do Hospital Amaral Carvalho de Jaú, totalizando 103 pacientes que receberam o diagnóstico de tumor testicular de células germinativas não-seminomas (TTCGNS) no período 1996-2010. Dentre os 103 casos, predominaram os TTCGMNS (57,3%). Nestes, observou-se o predomínio de marcação para EGFR e c-Kit. O EGFR foi expresso quando o componente coriocarcinoma era predominante e o c-Kit no componente epitelial do teratoma. A hipótese do estudo, que os casos positivos para os marcadores analisados estariam correlacionados com sobrevida menor, não foi confirmada pela analise estatística de Kaplan-Meier; seria necessário um maior número de casos para se chegar a uma conclusão quanto à sobrevida. Superexpressão, amplificação gênica e mutações ativadoras são frequentes em tumores testiculares germinativos; deste modo, o uso da técnica de Hibridização Fluorescente in situ (FISH) foi utilizada para avaliação dos eventos gênicos relativos a imunoexpressão proteica, observada pelos resultados encontrados no estudo imuno-histoquímico. Somente um caso, classificado como TTCGM, apresentava amplificação para gene EGFR. Este caso apresentou bom prognóstico. Considerou-se que, a ausência de amplificação observada na maioria dos casos, deve-se a qualidade inadequada do material parafinado e estocado. Conclui-se que, na série estudada, os TTCGNS expressam os marcadores EGFR, Her2 e c-Kit, a depender do subtipo histológico; entretanto, estas proteínas não tiveram impacto prognostico. A amplificação gênica para o EGFR pode ocorrer de forma isolada, porem devido a condições técnicas restritivas, não foi possível observa-la nos demais casos positivos para EGFR pela técnica de imuno-histoquímico.
Testicular neoplasms constitute approximately 1% of male cancers. Among these, germ cell tumors (TGCT) are the most prevalent. These tumors show varied morphological patterns and are distributed into two subgroups: seminomas and non-seminomas. The latter, in turn, are classified as embryonal carcinomas, endodermal sinus tumors, choriocarcinomas, teratomas and mixed germ cell tumors. The consensus in the literature is that histological verification of vascular invasion (VI) in the primary tumor is the best predictor of disease progression and recurrence. However, recent studies have highlighted the role of growth factors and their receptors for prognostic evaluation of TGCT, in which the use of immunohistochemistry is fundamental. This study sought to evaluate the occurrence of epidermal growth factor receptor (EGFR), Her2 and c-Kit in a series of primary non-seminoma TGCTs. In addition, possible relationships between the expression of these markers and patient evolution following conventional therapy was investigated. The series consisted of paraffin-embedded samples from the Laboratory of Anatomical Pathology and Cytology of Amaral Carvalho Hospital in Jaú, SP, Brazil, of 103 patients diagnosed with testicular non-seminoma germ cell tumor (NSGCT) over a 15-year period (1996-2010). Among the 103 cases, testicular NSGCT predominated (57.3%), and among these, staining for EGFR and c-Kit predominated. EGFR was expressed when the choriocarcinoma component was predominant, and c-Kit when the epithelial component of the teratoma was predominant. The initial hypothesis that positive cases for any marker would be correlated to lower survival was not confirmed by Kaplan-Meier survival probability studies. A larger number of cases is required to reach any conclusions concerning survival. Gene overexpression and amplification and activating mutations are common in testicular germinal tumors, thus fluorescent in situ hybridization (FISH) was used to validate the genic events results obtained in the immunohistochemical study. Only one case, classified as mixed TGCT, showed EGFR gene amplification, and this case presented good prognosis. The lack of amplification observed in most cases was due to the inadequate quality of the stored, paraffinembedded materials. In conclusion, in the series studied, testicular NSGCT expressed EGFR, Her2 and c-Kit markers depending on the histological subtype; however, these proteins had no prognostic impact. Gene amplification for EGFR may occur in isolation, but due to the limited technical conditions, it was not observed in the other cases positive for EGFR using immunohistochemistry.
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Quevedo, Francisco Carlos. "Tumores testiculares germinativos não-seminomas imunoexpressão protéica de EGFR, Her2 E c-Kit /." Botucatu, 2017. http://hdl.handle.net/11449/151631.

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Orientador: Maria Aparecida Custodio Domingues
Resumo: As neoplasias testiculares constituem aproximadamente 1% dos cânceres masculinos. Dentre eles, os tumores que têm origem nas células germinativas (TTCG) são os mais frequentes. Por sua natureza, esses tumores têm padrão morfológico variado, sendo distribuídos em dois subgrupos: os seminomas e os não-seminomas. Esses últimos, por sua vez, são classificados em carcinomas embrionários, tumores do seio endodérmico, coriocarcinomas, teratomas e tumores mistos de células germinativas. Há consenso na literatura de que a invasão vascular verificada histologicamente no tumor primário é o melhor indicador preditivo de progressão da doença e recidiva. Estudos recentes demonstram o papel dos fatores de crescimento e seus receptores para avaliação prognóstica dos TTCG, no que o uso da imuno-histoquímica é fundamental. O presente estudo procurou avaliar pela técnica imuno-histoquímica à ocorrência da expressão do receptor do fator de crescimento epidérmico (EGFR), do Her2 e do c-Kit em uma série de TTCG não-seminomas primários de testículo. Além disso, explorou a possível relação entre a expressão desses marcadores com a evolução dos pacientes após terapêutica convencional. A série foi constituída de amostras parafinadas existentes no Laboratório de Anatomia Patológica e Citologia do Hospital Amaral Carvalho de Jaú, totalizando 103 pacientes que receberam o diagnóstico de tumor testicular de células germinativas não-seminomas (TTCGNS) no período 1996-2010. Dentre os 103 casos, predominaram... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Testicular neoplasms constitute approximately 1% of male cancers. Among these, germ cell tumors (TGCT) are the most prevalent. These tumors show varied morphological patterns and are distributed into two subgroups: seminomas and non-seminomas. The latter, in turn, are classified as embryonal carcinomas, endodermal sinus tumors, choriocarcinomas, teratomas and mixed germ cell tumors. The consensus in the literature is that histological verification of vascular invasion (VI) in the primary tumor is the best predictor of disease progression and recurrence. However, recent studies have highlighted the role of growth factors and their receptors for prognostic evaluation of TGCT, in which the use of immunohistochemistry is fundamental. This study sought to evaluate the occurrence of epidermal growth factor receptor (EGFR), Her2 and c-Kit in a series of primary non-seminoma TGCTs. In addition, possible relationships between the expression of these markers and patient evolution following conventional therapy was investigated. The series consisted of paraffin-embedded samples from the Laboratory of Anatomical Pathology and Cytology of Amaral Carvalho Hospital in Jaú, SP, Brazil, of 103 patients diagnosed with testicular non-seminoma germ cell tumor (NSGCT) over a 15-year period (1996-2010). Among the 103 cases, testicular NSGCT predominated (57.3%), and among these, staining for EGFR and c-Kit predominated. EGFR was expressed when the choriocarcinoma component was predominant, and c-K... (Complete abstract click electronic access below)
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Goddard, Neil C. "Identification and role of activated receptor tyrosine kinases in testicular germ cell tumour subtypes of adolescents and adults." Thesis, Institute of Cancer Research (University Of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511166.

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Jostes, Sina Verena [Verfasser]. "The bromodomain inhibitor JQ1 as novel therapeutic option for type II testicular germ cell tumours / The role of SOX2 and SOX17 in regulating germ cell tumour pluripotency / Sina Verena Jostes." Bonn : Universitäts- und Landesbibliothek Bonn, 2019. http://d-nb.info/1194464874/34.

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Books on the topic "TESTICULAR GERM CELL TUMOR"

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Bagrodia, Aditya, and James F. Amatruda, eds. Testicular Germ Cell Tumors. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-0860-9.

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Derek, Raghavan, ed. Germ cell tumors. Hamilton, [Ont.]: BC Decker, 2003.

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Raghavan, Derek. Germ cell tumors. Hamilton [Ont.]: BC Decker, 2003.

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G, Jones W., Ward A. Milford, and Anderson C. K, eds. Germ cell tumours II: Proceedings of the 2nd Germ Cell Tumour Conference, Leeds, 15-19 April 1985. Oxford [Oxfordshire]: Pergamon Press, 1986.

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Germ, Cell Tumour Conference (3rd 1993 Leeds England). Germ cell tumours III: Proceedings of the 3rd Germ Cell Tumour Conference, held in Leeds, UK, on 8th-10th September 1993. Oxford, OX, England: Pergamon Press, 1994.

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Imperial Cancer Research Fund (Great Britain). Germ cell tumours of the testis. Edited by Andrews P. W and Oliver, R. T. D. (Roderick Timothy Desmond). Oxford, U.K: Published for the Imperial Cancer Research Fund by Oxford University Press, 1990.

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Amatruda, James F., and Aditya Bagrodia. Testicular Germ Cell Tumors: Methods and Protocols. Springer, 2021.

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Bagrodia, Aditya, and James Amatruda. Testicular Germ Cell Tumors: Methods and Protocols. Springer, 2020.

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Harnden, Patricia. Germ Cell Tumours V. Edited by Patricia Harnden. Springer-Verlag New York, Inc., 2002.

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Jones, W. G., and P. Harnden. Germ Cell Tumours III. Elsevier Science Pub Co, 1994.

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Book chapters on the topic "TESTICULAR GERM CELL TUMOR"

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Gospodarowicz, M. K., and J. F. G. Sturgeon. "Testicular Germ Cell Tumors." In Prognostic Factors in Cancer, 224–33. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79395-0_25.

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Jimenez, Rafael E., Sounak Gupta, Loren P. Herrera-Hernandez, and Thomas J. Sebo. "Testicular Germ Cell Tumors." In Pathology and Biology of Human Germ Cell Tumors, 267–325. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53775-6_7.

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Zargar-Shoshtari, Kamran, Craig Kovitz, Phillippe E. Spiess, and Nizar M. Tannir. "Testicular Germ Cell Tumors." In Encyclopedia of Cancer, 1–6. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-642-27841-9_2400-2.

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Albers, P., and H. Bender. "Testicular Germ Cell Tumors." In Atlas of Clinical PET in Oncology, 109–18. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-59706-0_10.

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Zargar-Shoshtari, Kamran, Craig Kovitz, Phillippe E. Spiess, and Nizar M. Tannir. "Testicular Germ Cell Tumors." In Encyclopedia of Cancer, 4499–504. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-46875-3_2400.

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Kovitz, Craig, Nizar M. Tannir, and Phillippe E. Spiess. "Testicular Germ Cell Tumors." In Encyclopedia of Cancer, 3656–60. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_2400.

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Beard, Clair. "Late Effects in Testicular Cancer Survivors." In Pediatric Germ Cell Tumors, 115–31. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-38971-9_8.

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Rapley, Elizabeth A. "Susceptibility Alleles for Testicular Germ Cell Tumor." In Male Reproductive Cancers, 317–35. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-0449-2_11.

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Nathanson, Katherine L. "Molecular Genetics of Testicular Germ Cell Tumor." In Male Reproductive Cancers, 181–99. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-0449-2_6.

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Schultz, Kris Ann P., Lindsay Frazier, and Dominik T. Schneider. "Ovarian and Testicular Sex Cord-Stromal Tumors." In Pediatric Germ Cell Tumors, 101–13. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-38971-9_7.

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Conference papers on the topic "TESTICULAR GERM CELL TUMOR"

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Hollern, Daniel P., Katie Hoadley, Benjamin Vincent, Charles M. Perou, and TCGA Testicular Germ Cell Tumor Ana Group. "Abstract 3703: A genomic characterization of testicular germ cell tumor immune microenvironment." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3703.

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Koster, Roelof, Peter A. Kanetsky, Nandita Mitra, Saran Vardhanabhuti, Stephanie L. Ciosek, Richard Letrero, Kurt D'Andrea, et al. "Abstract 2622: SNP markers in theFGF9andMAP3K1region associate with testicular germ cell tumor susceptibility." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2622.

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Degoricija, Lovorka, Kathy Y. Lee, Sunali Patel, Shirley Chu, Ad J. M. Gillis, Martin Rijlaarsdam, Lambert C. J. Dorssers, and Leendert Looijenga. "Abstract 3561: Whole transcriptome analysis of testicular germ cell tumors." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-3561.

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Trabert, Britton, Alice J. Sigurdson, Anne M. Sweeney, Sara S. Strom, and Katherine A. McGlynn. "Abstract LB-394: Marijuana use and testicular germ cell tumors." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-lb-394.

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Pyle, Louise C., John Pluta, Kevin T. Nead, Nandita Mitra, Javier Benitez, D. Timothy Bishop, Victoria Cortessis, et al. "Abstract 2684: Identification of 14 novel genetic loci for testicular germ cell tumor susceptibility." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2684.

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Pyle, Louise C., John Pluta, Kevin T. Nead, Nandita Mitra, Javier Benitez, D. Timothy Bishop, Victoria Cortessis, et al. "Abstract 2684: Identification of 14 novel genetic loci for testicular germ cell tumor susceptibility." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2684.

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Machiela, Mitchell J., Casey L. Dagnall, Anand Pathak, Jennifer T. Loud, Stephen J. Chanock, Mark H. Greene, Katherine A. McGlynn, and Douglas R. Stewart. "Abstract 811: Mosaic chromosome Y loss is not associated with testicular germ cell tumor risk." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-811.

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Svetlovska, Daniela, Michal Mego, Dana Cholujova, Paulina Gronesova, Patrik Palacka, Usakova Vanda, Vera Miskovska, Bibiana Vetrakova-Krakovska, Jan Luha, and Jozef Mardiak. "Abstract 4704: Correlation between serum cytokine/angiogenic factors (CAFs) and tumor markers in testicular germ cell tumor patients." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-4704.

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Chia, Victoria, Sabah Quraishi, Barry Graubard, Frank Stanczyk, Mark Rubertone, Ralph Erickson, and Katherine McGlynn. "Abstract A106: Serum testosterone concentrations and risk of testicular germ cell tumors." In Abstracts: Frontiers in Cancer Prevention Research 2008. American Association for Cancer Research, 2008. http://dx.doi.org/10.1158/1940-6207.prev-08-a106.

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Dorssers, Lambert C., Ad J. Gillis, Hans Stoop, Ronald Van Marion, Marleen M. Nieboer, Job Van Riet, Harmen J. Van de Werken, J. Wolter Oosterhuis, Jeroen de Ridder, and Leendert H. Looijenga. "Abstract 204: Reconstructing testicular germ cell cancer progression: Primary tumor heterogeneity and early metastatic clone selection." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-204.

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Reports on the topic "TESTICULAR GERM CELL TUMOR"

1

Lew, Chong Zhi, and Ting Chi Yeh. Pediatric Extracranial Germ Cell Tumor: Clinical Perspective of Autologous Hematopoietic Cell Transplantation. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2023. http://dx.doi.org/10.37766/inplasy2023.1.0081.

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Abstract:
Review question / Objective: A large number of systematic reviews and meta-analyses (SRs/MAs) involving sodium-glucose cotransporter-2 inhibitors (SGLT-2is) in the treatment of heart failure with preserved ejection fraction (HFpEF) have different outcomes. Condition being studied: The efficacy of SGLT-2is on HFpEF is currently a hot topic. However, the results of SRs/MAs conducted on relevant randomized controlled trials (RCTs) are inconsistent. We aim to conduct an umbrella review of existing SRs/MAs, to comprehensively evaluate study quality, and to incorporate calculated data from RCTs to update the results of primary outcomes.
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