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Journal articles on the topic "Tensor-based morphometry"

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Ashburner, John, Catriona Good, and Karl J. Friston. "Tensor based morphometry." NeuroImage 11, no. 5 (May 2000): S465. http://dx.doi.org/10.1016/s1053-8119(00)91396-x.

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Wang, Y., X. Gu, T. F. Chan, A. W. Toga, and P. M. Thompson. "Multivariate Statistics of Tensor-Based Cortical Surface Morphometry." NeuroImage 47 (July 2009): S100. http://dx.doi.org/10.1016/s1053-8119(09)70850-x.

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Muñoz-Ruiz, Miguel Ángel, Päivi Hartikainen, Juha Koikkalainen, Robin Wolz, Valtteri Julkunen, Eini Niskanen, Sanna-Kaisa Herukka, et al. "Structural MRI in Frontotemporal Dementia: Comparisons between Hippocampal Volumetry, Tensor-Based Morphometry and Voxel-Based Morphometry." PLoS ONE 7, no. 12 (December 20, 2012): e52531. http://dx.doi.org/10.1371/journal.pone.0052531.

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Khan, Ali R., Lei Wang, and Mirza Faisal Beg. "Unified voxel- and tensor-based morphometry (UVTBM) using registration confidence." Neurobiology of Aging 36 (January 2015): S60—S68. http://dx.doi.org/10.1016/j.neurobiolaging.2014.04.036.

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Chung, M. K., K. M. Dalton, and R. J. Davidson. "Tensor-Based Cortical Surface Morphometry via Weighted Spherical Harmonic Representation." IEEE Transactions on Medical Imaging 27, no. 8 (August 2008): 1143–51. http://dx.doi.org/10.1109/tmi.2008.918338.

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Yanovsky, Igor, Alex D. Leow, Suh Lee, Stanley J. Osher, and Paul M. Thompson. "Comparing registration methods for mapping brain change using tensor-based morphometry." Medical Image Analysis 13, no. 5 (October 2009): 679–700. http://dx.doi.org/10.1016/j.media.2009.06.002.

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Koikkalainen, Juha, Jyrki Lötjönen, Lennart Thurfjell, Daniel Rueckert, Gunhild Waldemar, and Hilkka Soininen. "Multi-template tensor-based morphometry: Application to analysis of Alzheimer's disease." NeuroImage 56, no. 3 (June 2011): 1134–44. http://dx.doi.org/10.1016/j.neuroimage.2011.03.029.

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Landin-Romero, Ramón, Erick J. Canales-Rodríguez, Fiona Kumfor, Ana Moreno-Alcázar, Mercè Madre, Teresa Maristany, Edith Pomarol-Clotet, and Benedikt L. Amann. "Surface-based brain morphometry and diffusion tensor imaging in schizoaffective disorder." Australian & New Zealand Journal of Psychiatry 51, no. 1 (July 11, 2016): 42–54. http://dx.doi.org/10.1177/0004867416631827.

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Background: The profile of grey matter abnormalities and related white-matter pathology in schizoaffective disorder has only been studied to a limited extent. The aim of this study was to identify grey- and white-matter abnormalities in patients with schizoaffective disorder using complementary structural imaging techniques. Methods: Forty-five patients meeting Diagnostic and Statistical Manual of Mental Disorders–Fourth Edition criteria and Research Diagnostic Criteria for schizoaffective disorder and 45 matched healthy controls underwent structural-T1 and diffusion magnetic resonance imaging to enable surface-based brain morphometry and diffusion tensor imaging analyses. Analyses were conducted to determine group differences in cortical volume, cortical thickness and surface area, as well as in fractional anisotropy and mean diffusivity. Results: At a threshold of p = 0.05 corrected, all measures revealed significant differences between patients and controls at the group level. Spatial overlap of abnormalities was observed across the various structural neuroimaging measures. In grey matter, patients with schizoaffective disorder showed abnormalities in the frontal and temporal lobes, striatum, fusiform, cuneus, precuneus, lingual and limbic regions. White-matter abnormalities were identified in tracts connecting these areas, including the corpus callosum, superior and inferior longitudinal fasciculi, anterior thalamic radiation, uncinate fasciculus and cingulum bundle. Conclusion: The spatial overlap of abnormalities across the different imaging techniques suggests widespread and consistent brain pathology in schizoaffective disorder. The abnormalities were mainly detected in areas that have commonly been reported to be abnormal in schizophrenia, and to some extent in bipolar disorder, which may explain the clinical and aetiological overlap in these disorders.
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Tao, Guozhi, Sushmita Datta, Renjie He, Flavia Nelson, Jerry S. Wolinsky, and Ponnada A. Narayana. "Deep gray matter atrophy in multiple sclerosis: A tensor based morphometry." Journal of the Neurological Sciences 282, no. 1-2 (July 2009): 39–46. http://dx.doi.org/10.1016/j.jns.2008.12.035.

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Whitwell, Jennifer L., Joseph R. Duffy, Mary M. Machulda, Heather M. Clark, Edythe A. Strand, Matthew L. Senjem, Jeffrey L. Gunter, et al. "Tracking the development of agrammatic aphasia: A tensor-based morphometry study." Cortex 90 (May 2017): 138–48. http://dx.doi.org/10.1016/j.cortex.2016.09.017.

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Dissertations / Theses on the topic "Tensor-based morphometry"

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Brun, Caroline Chantal Dominique. "A new Riemannian fluid registration algorithm with Lagrangian dissipation and its application to tensor-based morphometry." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1872911431&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Hua, Xue. "The application of tensor based morphometry in mapping human brain anatomical changes during normal and pathological conditions." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1779690341&sid=8&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Whitford, Thomas James. "A longitudinal study of brain structure in the early stages of schizophrenia." University of Sydney, 2007. http://hdl.handle.net/2123/1895.

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Doctor of Philosophy (PhD)
Schizophrenia is a severe mental illness that affects approximately 1% of the population worldwide, and which typically has a devastating effect on the lives of its sufferers. The characteristic symptoms of the disease include hallucinations, delusions, disorganized thought and reduced emotional expression. While many of the early theories of schizophrenia focused on its psychosocial foundations, more recent theories have focused on the neurobiological underpinnings of the disease. This thesis has four primary aims: 1) to use magnetic resonance imaging (MRI) to identify the structural brain abnormalities present in patients suffering from their first episode of schizophrenia (FES), 2) to elucidate whether these abnormalities were static or progressive over the first 2-3 years of patients’ illness, 3) to identify the relationship between these neuroanatomical abnormalities and patients’ clinical profile, and 4) to identify the normative relationship between longitudinal changes in neuroanatomy and electrophysiology in healthy participants, and to compare this to the relationship observed between these two indices in patients with FES. The aim of Chapter 2 was to use MRI to identify the neuroanatomical changes that occur over adolescence in healthy participants, and to identify the normative relationship between the neuroanatomical changes and electrophysiological changes associated with healthy periadolescent brain maturation. MRI and electroencephalographic (EEG) scans were acquired from 138 healthy participants between the ages of 10 and 30 years. The MRI scans were segmented into grey matter (GM) and white matter (WM) images, before being parcellated into the frontal, temporal, parietal and occipital lobes. Absolute EEG power was calculated for the slow-wave, alpha and beta frequency bands, for the corresponding cortical regions. The age-related changes in regional tissue volumes and regional EEG power were inferred with a regression model. The results indicated that the healthy participants experienced accelerated GM loss, EEG power loss and WM gain in the frontal and parietal lobes between the ages of 10 and 20 years, which decelerated between the ages of 20 and 30 years. A linear relationship was also observed between the maturational changes in regional GM volumes and EEG power in the frontal and parietal lobes. These results indicate that the periadolescent period is a time of great structural and electrophysiological change in the healthy human brain. The aim of Chapter 3 was to identify the GM abnormalities present in patients with FES, both at the time of their first presentation to mental health services (baseline), and over the first 2-3 years of their illness (follow-up). MRI scans were acquired from 41 patients with FES at baseline, and 47 matched healthy control subjects. Of these participants, 25 FES patients and 26 controls returned 2-3 years later for a follow-up scan. The analysis technique of voxel-based morphometry (VBM) was used in conjunction with the Statistical Parametric Mapping (SPM) software package in order to identify the regions of GM difference between the groups at baseline. The related analysis technique of tensor-based morphometry (TBM) was used to identify subjects’ longitudinal GM change over the follow-up interval. Relative to the healthy controls, the FES patients were observed to exhibit widespread GM reductions in the frontal, parietal and temporal cortices and cerebellum at baseline, as well as more circumscribed regions of GM increase, particularly in the occipital lobe. Furthermore, the FES patients lost considerably more GM over the follow-up interval than the controls, particularly in the parietal and temporal cortices. These results indicate that patients with FES exhibit significant structural brain abnormalities very early in the course of their illness, and that these abnormalities progress over the first few years of their illness. Chapter 4 employed the same methodology to investigate the white matter abnormalities exhibited by the FES subjects relative to the controls, both at baseline and over the follow-up interval. Compared to controls, the FES patients exhibited volumetric WM deficits in the frontal and temporal lobes at baseline, as well as volumetric increases at the fronto-parietal junction bilaterally. Furthermore, the FES patients lost considerably more WM over the follow-up interval than did the controls in the middle and inferior temporal cortex bilaterally. While there is substantial evidence indicating that abnormalities in the maturational processes of myelination play a significant role in the development of WM abnormalities in FES, the observed longitudinal reductions in WM were consistent with the death of a select population of temporal lobe neurons over the follow-up interval. The aim of Chapter 5 was to investigate the clinical correlates of the GM abnormalities exhibited by the FES patients at baseline. The volumes of four distinct cerebral regions where 31 patients with FES exhibited reduced GM volumes relative to 30 matched controls were calculated and correlated with patients’ scores on three primary symptom dimensions: Disorganization, Reality Distortion and Psychomotor Poverty. The results indicated that the greater the degree of atrophy exhibited by the FES patients in three of these four ‘regions-of-reduction’, the less severe their degree of Reality Distortion. These results suggest that an excessive amount of GM atrophy may in fact preclude the formation of hallucinations or highly systematized delusions in patients with FES. The aim of Chapter 6 was to identify the relationship between the longitudinal changes in brain structure and brain electrophysiology exhibited by 19 FES patients over the first 2-3 years of their illness, and to compare it to the normative relationship between the two indices reported in Chapter 2. The methodology employed for the parcellation of the MRI and EEG data was identical to Chapter 2. The results indicated that, in contrast to the healthy controls, the longitudinal reduction in GM volume exhibited by the FES patients was not associated with a corresponding reduction in EEG power in any brain lobe. In contrast, EEG power was observed to be maintained or even to increase over the follow-up interval in these patients. These results were consistent with the FES patients experiencing an abnormal elevation of neural synchrony. Such an abnormality in neural synchrony could potentially form the basis of the dysfunctional neural connectivity that has been widely proposed to underlie the functional deficits present in patients with schizophrenia. The primary aim of Chapter 7 was to assimilate the findings from the preceding empirical chapters with the theoretical framework provided in the literature, into an integrated and testable model of schizophrenia. The model emphasized dysfunctions in brain maturation, specifically in the normative processes of synaptic ‘pruning’ and axonal myelination, as playing a key role in the development of disintegrated neural activity and the subsequent onset of schizophrenic symptoms. The model concluded with the novel proposal that disintegrated neural activity arises from abnormal elevations in the synchrony of synaptic activity in patients with first-episode schizophrenia.
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Beckwith, Travis J. "A Magnetic Resonance Imaging Study of the Developmental Consequences of Childhood Lead Exposure in Adulthood." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439309120.

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Delmaire, Christine. "Exploration in vivo grâce à l'IRM des atteintes fonctionnelles, morphologiques et microstructurelles dans la dystonie." Paris 6, 2007. http://www.theses.fr/2007PA066595.

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La dystonie est une pathologie du mouvement dont la physiopathologie est mal connue. Jusqu'à présent, les données de l'imagerie IRM classique étaient décevantes, en particulier dans les dystonies primaires. Le développement de nouvelles techniques d'imagerie offre la possibilité d'explorer cette pathologie de façon plus précise avec les techniques d'analyse morphométrique voxel à voxel (VBM) et d'imagerie du tenseur de diffusion (DTI). Dans ce travail, nous avons utilisé une approche IRM multimodale pour étudier la physiopathologie de la dystonie. A l'aide de l'imagerie par résonance magnétique fonctionnelle, nous avons étudié la sélectivité des représentations neuronales dans le striatum des patients atteints de crampe des écrivains avant et après rééducation fonctionnelle. Nous avons recherché des anomalies structurelles à l'aide de la VBM et utilisé la tractographie pour rechercher une atteinte spécifique des fibres cortico - striatales sensorimotrices chez ces patients. Nous avons combiné une approche anatomique et par tractographie pour localiser le territoire fonctionnel des ganglions de la base lésé dans les dystonies secondaires à des lésions ischémiques. L'ensemble de nos travaux souligne le rôle du circuit sensorimoteur cortex - ganglions de la base - cervelet dans la physiopathologie de la dystonie
Dystonia is a movement disorder whose pathophysiology is not fully understood. To date, conventional MR imaging was unsuccessful in showing structural abnormality in primary dystonia. New recent imaging techniques, such as voxel based morphometry (VBM) and diffusion tensor imaging (DTI), can be utilized to explore more precisely the pathophysiology of dystonia. In this work, we used several MRI methods to investigate the pathophysiology of dystonia. We used fMRI to determine whether the selectivity of neuronal representation of basal ganglia neurons was altered in the putamen of patients with focal hand dystonia before and after rehabilitation. Using voxel-based morphometry and DTI, we tested the hypothesis that structural or microstructural changes occur in the sensorimotor basal ganglia - cortical circuit in primary focal hand dystonia. Lastly, we combined structural imaging and fiber tracking to determine the functionnal territory of the basal ganglia that is damaged in post stroke dystonia. Overall, our results show that cortico striatal thalamo cerebellar sensorimotor circuit is likely to play a fundamental role in the pathophysiology of the dystonia
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Yip, S. W. "The bipolar phenotype : behavioural and neurobiological characteristics." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:b7091bbc-27c7-4377-a475-601bb6010440.

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Background: Adolescence and young adulthood are particularly vulnerable periods for the development of mental health disorders, including bipolar disorder (BD). Mental health screening at universities could aid in the early identification of particularly at- risk individuals, with the long-term aim of providing early treatment interventions to improve clinical outcomes. However, further research into the identification of appropriate behavioral and biological markers for vulnerability to psychiatric disorders – as well as into the acceptability and efficacy of mental health screening - is warranted. Methods: Young adults were recruited via an already existing Internet-based mental health screening survey of undergraduate students at the University of Oxford. In Study 1, qualitative interviews of young adults with and without previous mental health problems were conducted to assess the acceptability and efficacy of mental health screening within a university setting. In Studies 2-5 we explored the hypotheses of altered emotional decision-making, reward processing and neurostructural integrity as behavioral and neurobiological markers for vulnerability to bipolar disorder via the study of young adults with a common bipolar phenotype (BPP) - some of whom meet diagnostic criteria for bipolar II or not-otherwise-specified disorder (BD II/NOS). To that end, we employed a diverse range of methodologies: alcohol challenge (Study 2); neuropsychological task performance (Study 3); functional magnetic resonance imaging (fMRI; Study 4); diffusion tensor imaging (DTI) and voxel-based morphometry (VBM; Study 5). Results: Findings from Study 1 suggest that young adults are willing to participate in mental health screening within a university setting, and that such screening may be used to offer subsequent treatment interventions. Taken together, findings from Studies 2 and 4 suggest a general blunted reward response among unmedicated young adults at increased risk for BD during euthymia, and additionally suggest pathophysiological similarities between BD and alcohol use disorders (AUDs) that may provide a causal link between the elevated co-occurrence rates of the two disorders. Finally, findings from Study 5 suggest widespread white matter microstructural alterations – which are likely to be neurodevelopmental in origin – among antipsychotic- and mood-stabilizer naïve young adults with BD II/NOS. Conclusions: These data support the hypothesis of neurodevelopmental alterations identifiable prior to significant clinical impairment among young adults at increased risk of – or already meeting DSM-IV criteria for – bipolar disorder. They also suggest that young adults in higher education are willing to participate in mental health screening. Future studies should aim to identify more specific markers for individual disorders such as BD.
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Borlase, Nadia Miree. "The thalamus in Parkinson's disease: a multimodal investigation of thalamic involvement in cognitive impairment." Thesis, University of Canterbury. Psychology, 2013. http://hdl.handle.net/10092/8689.

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Parkinson’s disease patients present with the highest risk of dementia development. The thalamus, integral to several functions and behaviours is involved in the pathophysiology of Parkinson’s disease. The aim of this thesis was to determine if anatomical abnormalities in the thalamus are associated with the development of dementia in Parkinson’s disease. We examined the thalamus using macro and microstructural techniques and the white matter pathways that connect the thalamus with areas of the surrounding cortex using diffusion tensor imaging (DTI) based tractography. T1-weighted magnetic resonance and DT images were collected in 56 Parkinson’s disease patients with no cognitive impairment, 19 patients with mild cognitive impairment, 17 patients with dementia and 25 healthy individuals who acted as control subjects. An established automated segmentation procedure (FIRST FSL) was used to delineate the thalamus and a modified k-means clustering algorithm applied to segment the thalamus into clusters assumed to represent thalamic nuclei. Fibre tracts were determined using DTI probabilistic tracking methods available in FIRST. Microstructural integrity was quantified by fractional anisotropy and mean diffusivity (MD) DTI measures. Results show that microstructural measures of thalamic integrity are more sensitive to cognitive dysfunction in PD than macrostructural measures. For the first time we showed a progressive worsening of cellular integrity (MD) in the groups who had greater levels of cognitive dysfunction. Thalamic degeneration was regionally specific and most advanced in the limbic thalamic nuclei which influenced executive function and attention, areas of cognition that are known to be affected in the earliest stages of PD. The integrity of the fibre tracts corresponding to these thalamic regions was also compromised. Degeneration of fibre tracts was most evident in the dementia group, indicating that they may be more protected against Lewy pathology than the nuclei of the thalamus. Our findings confirm previous histological, animal and lesion studies and provide a reliable estimate of cortical degeneration in PD that can be applied non-invasively and in vivo. A longitudinal study is needed to monitor the progression of cognitive decline in PD but we have provided the basis for further investigation into the predictive validity of thalamic degeneration for cognitive dysfunction. In the future, the microstructural changes of the thalamus could be used as biomarkers for the identification of individuals with a higher risk for dementia development and for the longitudinal monitoring of any interventions into cognitive decline.
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Carmo, Samuel Sullivan. "Características do envolvimento do Sistema Nervoso Central na Polirradiculoneuropatia Inflamatória Desmielinizante Crônica: um estudo mediante técnicas quantitativas de Imagem por Ressonância Magnética." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17140/tde-16092014-170302/.

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A polineuropatia inflamatória desmielinizante crônica (PIDC) é uma síndrome caracterizada fundamentalmente pela disfunção do Sistema Nervoso Periférico e que afeta muito a qualidade de vida dos pacientes. O envolvimento da PIDC com o Sistema Nervoso Central tem sido descrito, maiormente como sendo subclínico, porém não há estudos sobre a caracterização deste envolvimento de uma forma ampla e quantitativa. Avaliamos 11 pacientes com PIDC, todos tratados e sem sinais clínicos de alterações centrais, e 11 controles, pareados em gênero e faixa etária de 19 a 69 anos. Foram adquiridas neuroimagens em uma máquina de Ressonância Magnética de alto campo (3T) usando diferentes técnicas de imagens; volumétricas ponderadas em T1, volumétricas de inversão e recuperação com atenuação de fluidos e ponderadas em T2, relaxométricas de cinco ecos para mapas de T2, de transferência de magnetização e por tensor de difusão. As imagens foram processadas em diferentes ferramentas computacionais e foram obtidos resultados para estudos da difusibilidade, volumetria, morfometria, tratometria e conectividade cerebral, além de achados radiológicos para os pacientes. As análises de grupos foram executadas por; 1) testes paramétricos monocaudais de duas amostras pareadas para os resultados da volumetria, da tratometria e conectividade cerebral; 2) mapeamento estatístico paramétrico para os resultados da morfometria baseada em voxel e; 3) estatística espacial baseada em tratos para os resultados da difusibilidade. Foram detectas alterações em todas as comparações. Os principais achados indicam um envolvimento possivelmente caracterizado por uma perda volumétrica encefálica generalizada, sobretudo nas regiões periventriculares associadas a ventrículos proeminentes acrescido de, um aumento da difusibilidade transversa e oblíqua nos maiores tratos de substância branca e, também há uma perda de densidade na substância branca periventricular e um aumento na substância cinzenta em uma região que sinaliza para o espessamento trigeminal bilateral e, uma redução geral da conectividade cerebral estrutural.
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is a severe disease fundamentally characterized by dysfunction of the Peripheral Nervous System and affects greatly the quality of life of patients. The Central Nervous System (CNS) involvement in CIDP has not been described using recent quantitative neuroimaging techniques. We evaluated 11 patients with CIDP, all treated and without clinical signs of central alterations and 11 controls matched for gender and age group of 19 to 69 years. Magnetic Resonance Imaging were performed on a 3T scanner using different imaging techniques; structural 3D T1-weighted, fluid-attenuated inversion recovery, relaxometry with 5 echoes pulse sequence for T2 maps, magnetization transfer weighted and diffusion tensor imaging. The images were processed on different tools and were obtained results for the studies of diffusivity, volumetry, morphometry, tractometry, brain connectivity, and radiological findings of patients. Different statistical group analyses were performed in the quantitative results: 1) Parametric test for volumetry, tractometry and brain connectivity; 2) Parametric mapping for voxel morphometry; 3) Tract-based spatial statistics (TBSS) for diffusion coefficients. Changes were detected in all comparisons. In the patients, our main findings are: generalized loss brain volume more pronounced in periventricular regions associated with prominent ventricles, increased simultaneously perpendiculars and parallel diffusivity in the major tracts of the TBSS analyze, white matter density loss in the periventricular area, some bilateral trigeminal thickening, and general reduction of the brain connectivity. The CIDP affects the global brain and represents a demyelination in the CNS.
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"Combining Thickness Information with Surface Tensor-based Morphometry for the 3D Statistical Analysis of the Corpus Callosum." Master's thesis, 2013. http://hdl.handle.net/2286/R.I.20930.

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abstract: In blindness research, the corpus callosum (CC) is the most frequently studied sub-cortical structure, due to its important involvement in visual processing. While most callosal analyses from brain structural magnetic resonance images (MRI) are limited to the 2D mid-sagittal slice, we propose a novel framework to capture a complete set of 3D morphological differences in the corpus callosum between two groups of subjects. The CCs are segmented from whole brain T1-weighted MRI and modeled as 3D tetrahedral meshes. The callosal surface is divided into superior and inferior patches on which we compute a volumetric harmonic field by solving the Laplace's equation with Dirichlet boundary conditions. We adopt a refined tetrahedral mesh to compute the Laplacian operator, so our computation can achieve sub-voxel accuracy. Thickness is estimated by tracing the streamlines in the harmonic field. We combine areal changes found using surface tensor-based morphometry and thickness information into a vector at each vertex to be used as a metric for the statistical analysis. Group differences are assessed on this combined measure through Hotelling's T2 test. The method is applied to statistically compare three groups consisting of: congenitally blind (CB), late blind (LB; onset > 8 years old) and sighted (SC) subjects. Our results reveal significant differences in several regions of the CC between both blind groups and the sighted groups; and to a lesser extent between the LB and CB groups. These results demonstrate the crucial role of visual deprivation during the developmental period in reshaping the structural architecture of the CC.
Dissertation/Thesis
M.S. Computer Science 2013
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Moayedi, Massieh. "Structural Brain Abnormalities in Temporomandibular Disorders." Thesis, 2012. http://hdl.handle.net/1807/34816.

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Temporomandibular disorders (TMD) are a family of prevalent chronic pain disorders affecting masticatory muscles and/or the temporomandibular joint. There is no unequivocally recognized peripheral aetiology for idiopathic TMD. The central nervous system (CNS) may initiate and/or maintain the pain in idiopathic TMD due to sustained or long-term nociceptive input that induces maladaptive brain plasticity, and/or to inherent personality-related factors that may reduce the brain's capacity to modulate nociceptive activity. The main aim of this thesis is to determine whether there are structural neural abnormalities in patients with TMD, and whether these abnormalities are related to TMD pain characteristics, or to neuroticism. The specific aims are to delineate in TMD: (1) gray matter (GM) brain abnormalities and the contribution of pain and neuroticism to abnormalities; (2) the contribution of abnormal brain GM aging in focal cortical regions associated with nociceptive processes; and (3) abnormalities in brain white matter and trigeminal nerve and the contribution of pain. In groups of 17 female patients with TMD and 17 age- and sex- matched controls, magnetic resonance imaging revealed that patients with TMD had: (1) thicker cortex in the somatosensory, ventrolateral prefrontal and frontal polar cortices than controls, (2) cortical thickness in motor and cognitive areas that was negatively related to pain intensity, orbitofrontal cortical thickness that was negatively correlated to pain unpleasantness, and thalamic GM volume correlated to TMD duration, (3) an abnormal relationship between neuroticism and orbitofrontal cortical thickness, (4) abnormal GM aging in nociceptive, modulatory and motor areas, (5) widespread abnormalities in white matter tracts in the brain related to sensory, motor and cognitive functions, (6) reduced trigeminal nerve integrity related to pain duration, and (7) abnormal connectivity in cognitive and modulatory brain regions. In sum, this thesis demonstrates for the first time abnormalities in both peripheral nerve and CNS in patients with TMD.
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Books on the topic "Tensor-based morphometry"

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Boedhoe, Premika S. W., and Odile A. van den Heuvel. The Structure of the OCD Brain. Edited by Christopher Pittenger. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190228163.003.0023.

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This chapter summarizes the most consistent findings of structural neuroimaging studies of obsessive-compulsive disorder (OCD), and discusses their relationship within the implicated brain networks. The techniques used in these studies are diverse, and include manual tracing of specific regions of interest, whole-brain voxel-based morphometry (VBM) for both gray matter and white matter volume comparisons, FreeSurfer to investigate differences in cortical thickness and subcortical volumes, and other methods such as covariance analyses. Findings on white matter integrity with tract-based spatial statistics (TBSS) and in diffusion tensor imaging (DTI) studies are discussed as well.The literature shows that the pathophysiology of OCD cannot be explained by alterations in function and structure of the classical cortico-striato-thalamo-cortical (CSTC) regions exclusively, but that fronto-limbic and fronto-parietal connections are important as well, and the role of the cerebellum needs more attention in future research.
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Book chapters on the topic "Tensor-based morphometry"

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Ingalhalikar, Madhura, Parmeshwar Khurd, and Ragini Verma. "Kernel-Based Morphometry of Diffusion Tensor Images." In Mathematics and Visualization, 229–47. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54301-2_10.

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Leporé, Natasha, Caroline Brun, Xavier Pennec, Yi-Yu Chou, Oscar L. Lopez, Howard J. Aizenstein, James T. Becker, Arthur W. Toga, and Paul M. Thompson. "Mean Template for Tensor-Based Morphometry Using Deformation Tensors." In Medical Image Computing and Computer-Assisted Intervention – MICCAI 2007, 826–33. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-75759-7_100.

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Shi, Jie, Paul M. Thompson, and Yalin Wang. "Human Brain Mapping with Conformal Geometry and Multivariate Tensor-Based Morphometry." In Multimodal Brain Image Analysis, 126–34. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-24446-9_16.

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Wang, Yalin, Tony F. Chan, Arthur W. Toga, and Paul M. Thompson. "Multivariate Tensor-Based Brain Anatomical Surface Morphometry via Holomorphic One-Forms." In Medical Image Computing and Computer-Assisted Intervention – MICCAI 2009, 337–44. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-04268-3_42.

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Zhang, Hui, Paul A. Yushkevich, Daniel Rueckert, and James C. Gee. "Tensor-Based Morphometry of Fibrous Structures with Application to Human Brain White Matter." In Medical Image Computing and Computer-Assisted Intervention – MICCAI 2009, 466–73. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-04271-3_57.

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Bossa, Matías Nicolás, Ernesto Zacur, and Salvador Olmos. "Tensor-Based Morphometry with Mappings Parameterized by Stationary Velocity Fields in Alzheimer’s Disease Neuroimaging Initiative." In Medical Image Computing and Computer-Assisted Intervention – MICCAI 2009, 240–47. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-04271-3_30.

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Lepore, Natasha, Caroline A. Brun, Ming-Chang Chiang, Yi-Yu Chou, Rebecca A. Dutton, Kiralee M. Hayashi, Oscar L. Lopez, et al. "Multivariate Statistics of the Jacobian Matrices in Tensor Based Morphometry and Their Application to HIV/AIDS." In Medical Image Computing and Computer-Assisted Intervention – MICCAI 2006, 191–98. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/11866565_24.

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Brun, Caroline, Natasha Leporé, Xavier Pennec, Yi-Yu Chou, Agatha D. Lee, Marina Barysheva, Grieg de Zubicaray, et al. "A Tensor-Based Morphometry Study of Genetic Influences on Brain Structure Using a New Fluid Registration Method." In Medical Image Computing and Computer-Assisted Intervention – MICCAI 2008, 914–21. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-85990-1_110.

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Ashburner, J., and G. R. Ridgway. "Tensor-Based Morphometry." In Brain Mapping, 383–94. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-397025-1.00309-2.

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"Tensor-Based Morphometry." In Computational Neuroanatomy, 49–68. WORLD SCIENTIFIC, 2012. http://dx.doi.org/10.1142/9789814335447_0003.

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Conference papers on the topic "Tensor-based morphometry"

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Kim, Seung-Goo, Moo K. Chung, Jamie L. Hanson, Brian B. Avants, James C. Gee, Richard J. Davidson, and Seth D. Pollak. "Structural connectivity via the tensor-based morphometry." In 2011 8th IEEE International Symposium on Biomedical Imaging (ISBI 2011). IEEE, 2011. http://dx.doi.org/10.1109/isbi.2011.5872528.

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Paniagua, Beatriz, Abeer Alhadidi, Lucia Cevidanes, Martin Styner, and Ipek Oguz. "Mandibular asymmetry characterization using generalized tensor-based morphometry." In 2011 8th IEEE International Symposium on Biomedical Imaging (ISBI 2011). IEEE, 2011. http://dx.doi.org/10.1109/isbi.2011.5872611.

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Villalon, Julio, Anand A. Joshi, Natasha Lepore, Caroline Brun, Arthur W. Toga, and Paul M. Thompson. "Comparison of volumetric registration algorithms for tensor-based morphometry." In 2011 8th IEEE International Symposium on Biomedical Imaging (ISBI 2011). IEEE, 2011. http://dx.doi.org/10.1109/isbi.2011.5872694.

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Rajagopalan, Vidya, Armin Schwartzman, Xue Hua, Alex Leow, Paul Thompson, and Natasha Lepore. "Multivariate analysis of eigenvalues and eigenvectors in tensor based morphometry." In Tenth International Symposium on Medical Information Processing and Analysis, edited by Eduardo Romero and Natasha Lepore. SPIE, 2015. http://dx.doi.org/10.1117/12.2073737.

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Yalin Wang, Tony F. Chan, Arthur W. Toga, and Paul M. Thompson. "Shape analysis with multivariate tensor-based morphometry and holomorphic differentials." In 2009 IEEE 12th International Conference on Computer Vision (ICCV). IEEE, 2009. http://dx.doi.org/10.1109/iccv.2009.5459422.

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Michalkiewicz, Mateusz, Akshay Pai, Kelvin K. Leung, Stefan Sommer, Sune Darkner, Lauge Sørensen, Jon Sporring, and Mads Nielsen. "Combining the boundary shift integral and tensor-based morphometry for brain atrophy estimation." In SPIE Medical Imaging, edited by Martin A. Styner and Elsa D. Angelini. SPIE, 2016. http://dx.doi.org/10.1117/12.2217089.

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Zhang, Jie, Cynthia Stonnington, Qingyang Li, Jie Shi, Robert J. Bauer, Boris A. Gutman, Kewei Chen, et al. "Applying sparse coding to surface multivariate tensor-based morphometry to predict future cognitive decline." In 2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI 2016). IEEE, 2016. http://dx.doi.org/10.1109/isbi.2016.7493350.

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Wang, Yalin, Jie Zhang, Tony F. Chan, Arthur W. Toga, and Paul M. Thompson. "Multivariate tensor-based morphometry on surfaces: Application to mapping ventricular changes in HIV/AIDS." In 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI). IEEE, 2009. http://dx.doi.org/10.1109/isbi.2009.5193000.

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Kim, Seung-Goo, Brian B. Avants, Hyekyoung Lee, James C. Gee, Moo K. Chung, Richard J. Davidson, Jamie L. Hanson, and Seth D. Pollak. "Agreement between the white matter connectivity based on the tensor-based morphometry and the volumetric white matter parcellations based on diffusion tensor imaging." In 2012 IEEE 9th International Symposium on Biomedical Imaging (ISBI 2012). IEEE, 2012. http://dx.doi.org/10.1109/isbi.2012.6235479.

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Li, Wenjing, Huiguang He, Jingjing Lu, Bin Lv, Meng Li, and Zhengyu Jin. "Detection of whole-brain abnormalities in temporal lobe epilepsy using tensor-based morphometry with DARTEL." In Sixth International Symposium on Multispectral Image Processing and Pattern Recognition, edited by Jianguo Liu, Kunio Doi, Aaron Fenster, and S. C. Chan. SPIE, 2009. http://dx.doi.org/10.1117/12.833128.

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