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Relevant bibliographies by topics / Tendon healing / Dissertations / Theses

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Dissertations / Theses on the topic 'Tendon healing'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Blomgran, Parmis. "Inflammation and tendon healing." Doctoral thesis, Linköpings universitet, Avdelningen för Kirurgi, Ortopedi och Onkologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-142349.

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Tendons heal through three different overlapping phases; the inflammatory, proliferative and remodeling phase. Many studies have investigated what factors influence healing of tendons. However, little was known about inflammation and the immune cells present during Achilles tendon healing by the time this thesis started. We developed a flow cytometry method for our rat model of tendon healing, which enabled us to study different leukocyte subpopulations during Achilles tendon healing. The general aim of this thesis was to understand more about inflammation and the immune cell populations prese

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2

Murrell, George Anthony Calvert St George Clinical School UNSW. "Nitric oxide and tendon healing." Awarded by:University of New South Wales. St George Clinical School, 2006. http://handle.unsw.edu.au/1959.4/31887.

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Nitric oxide is a small free radical generated by family of enzymes, the nitric oxide synthases. In a series of experiments performed over the last 15 years we showed that nitric oxide is induced by all three isoforms of nitric oxide synthase during tendon healing and that it plays a crucial beneficial role in restoring tendon function. In normal tendon we found very little nitric oxide synthase activity while in injured rat and human tendons nitric oxide synthase activity was expressed in healing fibroblasts in a temporal fashion. In healing rat Achilles tendon fibroblasts the first isoform

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3

Molloy, Timothy John St George Clinical School UNSW. "Gene expression in healing tendon." Awarded by:University of New South Wales. St George Clinical School, 2006. http://handle.unsw.edu.au/1959.4/23939.

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Tendon injury is painful and often debilitating, and is a one of the most prevalent soft tissue injuries encountered in the clinic. While common, the underlying molecular and genetic processes of tendon damage and repair remain poorly understood. The work described herein used genome-wide expression analyses to investigate tendon injury and healing from three perspectives. The first identified novel gene expression in tendon fibroblasts following their stimulation with nitric oxide (NO). Of particular relevance to tendon healing was the observation that stimulated fibroblasts express a number

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4

Berglund, Maria. "Biomolecular Aspects of Flexor Tendon Healing." Doctoral thesis, Uppsala universitet, Handkirurgi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120304.

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Flexor tendon injuries in zone II of the hand (i.e. between the distal volar crease and the distal interphalangeal joint) can be costly for both the afflicted individual and society because of the high cost of a long rehabilitation period, complicated by tendon ruptures or scarring with adhesion formation, causing impaired range of motion. The aim of the present thesis was to characterize more fully the deep flexor tendon, the tendon sheath and their response to injury in a rabbit model in order to find potential targets to improve the outcome of repair. The intrasynovial rabbit deep flexor te

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5

Schepull, Thorsten. "Stiffness of the healing human Achilles tendon." Doctoral thesis, Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-91727.

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Achilles tendon ruptures in humans are followed by a long period of immobilisation, rehabilitation and limitations of physical activity and sometimes work also. This prolonged period probably leaves a marginal for improvement in the management of this injury. Animal studies have shown that there are several possibilities to influence and improve tendon healing. The aim of this thesis was to find a way to examine the mechanical properties of the healing human Achilles tendon and, by using that method, to gain a better understanding of the tissue properties and healing process in these tendons.

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6

Brooks, Jonathan Peter. "The biology of the tendon in development and healing." Thesis, University of Manchester, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488287.

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The biology of tendons has been extensively investigated previously. Many studies have looked into the development and healing of tendons. An overall picture of the events in tendon development and healing, in terms of recently recognised functional molecules is missing, particularly in a single model. The recent understanding of the importance of metalloproteinases and other enzymes in ECM degradation suggests they may be of importance in tendon healing and development. Another unexplored area with relevance to wound healing and development is the functional integrin molecules. This thesis lo

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7

Stevenson, John Howard. "An investigation into the effect of ultrasound on repaired tendons." Thesis, Queen's University Belfast, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335315.

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8

Harrison, R. "The elucidation and strategic modification of flexor tendon healing mechanisms." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445576/.

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Introduction and aims: 16,000 flexor tendon repair operations are performed annually in the UK these are frequently complicated by adhesions, causing significant morbidity. The uncertainty over which cells are responsible for the tendon healing mechanisms persists. We aimed to develop a novel experimental model to elucidate the possible role and migratory response of synovial sheath fibroblasts during tendon healing and to determine the effects of differing environment and stimuli on the cellular processes in the healing tendon. 0.1.2 Materials and methods: Rat synovial sheath cells were label

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9

Virchenko, Olena. "Stimulation of tendon repair by platelet concentrate, CDMP-2 and mechanical loading in animal models." Doctoral thesis, Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med1005s.pdf.

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10

Kinneberg, Kirsten R. C. "Tissue Engineering Strategies to Improve Tendon Healing and Insertion Site Integration." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307106075.

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11

Dyment, Nathaniel A. "Using Development and Natural Healing as a Paradigm to Improve Tendon Repair." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1320083190.

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12

Subramanian, Gayathri Gowri. "Mechanically-Conditioned Biphasic Composite Scaffolds to Augment Healing of Tendon-Bone Interface." University of Toledo / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1500469300203445.

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13

Jones, Martin Edward. "The cellular mechanisms of hand flexor tendon healing and their strategic modification." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399269.

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14

Bajuri, Mohd Nazri Bin. "Mechanobiological analyses of healing tendons using computational approaches." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:c6daa0b7-4875-4056-b05e-c35097988b72.

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The healing process of ruptured tendons is problematic due to scar tissue formation and deteriorated material properties. In some cases, it may take nearly a year to complete. Mechanical loading has been shown to positively influence tendon healing; however, the mechanisms remain unclear. Computational mechanobiology methods employed extensively to model bone healing have achieved high fidelity, but not yet been explored to understand tendon regeneration. The general objective of this thesis is to develop computational approaches to enhance the knowledge of the role that mechanical factors pla

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15

Lalley, Andrea L. "Identifying and Evaluating Novel Biological Targets to Improve Musculoskeletal Tissue Engineering Strategies." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1416231302.

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16

Davidson, K. Elaine. "Flexor tendon healing : evaluation of peritendinous adhesion formation and tendon strength after tenotomy and primary repair in an ovine model." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29086.

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This experimental study was designed to assess the effects of different surgical repair techniques on the process of flexor tendon healing. In particular, it aimed to evaluate the effects of incorporating a novel biocompatible, biodegradable ‘wrap’ into the process of tendon repair. This inorganic polymer wrap, Controlled Release Glass (Giltech Limited, Ayr, Scotland, UK) was composed of a combination of sodium and calcium cations with phosphate and oxide anions and degraded into simple ionic substances normally found in tissue fluid. The hypothesis to be tested stated that ‘the addition of th

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17

Al, Youha Sarah. "Towards an understanding of the mechanisms of acellular zone formation in sutured tendons." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/towards-an-understanding-of-the-mechanisms-of-acellular-zone-formation-in-sutured-tendons(a942e6b2-44e4-44dc-a949-34ce3b39e6f4).html.

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Fibrotic diseases account for an estimated 45% of the total number of deaths in the developed world (Wynn 2007). Tendons are an excellent model for studying the dysregulated response which leads to fibrosis, as tendons have an organized, parallel matrix, in which tissue defects could easily be distinguished. Wong et al. (2006b) demonstrated the presence of a bell-shaped region around sutures in tendons that was devoid of cells in histological sections. The mechanisms of the formation of this acellular zone, that was also noted in cornea and cartilage (Matsuda et al. 1999; Hunziker and Stähli 2

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18

Medeiros, Jordan-Ryan J. I. K. "Effects of calcium carbonate particulate releasing surgical anchors on bone and tendon healing." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/57971.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2007.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 31-32).<br>The Calaxo ® screw, developed by Smith and Nephew, is a novel biomedical composite composed of poly-DL-lactide-co-glycolide (PLLA:PGA) 85:15 and calcium carbonate particulates. Comparisons to an identical surgical anchor composed of PLLA, largely considered an industry standard, shows increased mean failure strength in surgical reconstructions of the patellar-tibia complex in sheep. SEM imaging con

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19

Malis, Emma. "The Effect of Mechanical Stimuli on Healing Achilles Tendons in Rats." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19329.

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<p>Tendon healing is a slow process and the tendon may not regain its initial mechanical properties after rupture. Mechanical stimuli have shown to have positive effect on tendon healing. This study is the first to investigate the effect of vibration stimuli on healing tendons. Vibration was also compared to treadmill running, which has previously been used for mechanical stimuli.63 female Sprauge-Dawley rats were used. A 3 mm segment was removed from the Achilles tendon and the tendon was left to heal. The animals were subjected to 15 min of daily exercise, vibration or treadmill running or a

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20

Khatibzadeh, Sarah M. "Porcine urinary bladder matrix in an in vitro equine model of tenogenesis." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/93224.

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Extracellular matrix (ECM) is responsible for tendon strength and elasticity. Healed tendon ECM lacks structural integrity, leading to reinjury. Porcine urinary bladder matrix (UBM) provides a scaffold and source of bioactive proteins to improve tissue healing, but has received limited attention for treating tendon injuries. The objective of this study was to evaluate the ability of UBM to induce matrix organization and tenogenesis using a novel in vitro model. We hypothesized that addition of UBM to tendon ECM hydrogels would improve matrix organization and cell differentiation. Hydrogel

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21

Thangarajah, T. "Augmentation of rotator cuff tendon-bone healing using demineralised bone matrix and mesenchymal stem cells." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10027670/.

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BACKGROUND: The results of surgery for tears of the rotator cuff are variable, with failure occurring in up to 94% of cases. Demineralised bone matrix (DBM) consists of a collagen scaffold containing multiple growth factors and has been used successfully to improve tendon-bone healing. By combining DBM with stem cells its effects may be enhanced given that many of the growth factors it contains are able to direct stem cell differentiation down tenogenic, chondrogenic, and osteogenic lineages. These cell lines produce elements essential to the formation of a naturally graded enthesis. AIM: To i

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22

Brown, Phillip G. M. "2D ultrasound elastography as a functional measure of healing of the Achilles tendon in vivo." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:e2d0a97e-d557-4b5a-869a-36cbd33b9994.

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The Achilles tendon is the largest tendon in the human body, which elastically stores and releases energy to facilitate walking and running. Tendons can suffer from a range of pathologies, most notably that of complete rupture, which affects athletes, physically active workers and the aged. There is a growing demand for in vivo methods of objectively measuring tendon health for aiding diagnosis, monitoring therapy and for assessment of new treatments. Knowledge of the changes in mechanical properties during the healing process is also limited and new methods to accurately and consistently esti

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23

Junior, Edson Alves de Barros. "Os efeitos do ultra-som na cicatrização de tendões flexores de coelhos após tenorrafia." Universidade de São Paulo, 2001. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-07112001-090924/.

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A utilização do ultra som com a finalidade de acelerar o reparo tecidual é muito freqüente na prática clínica, embora as bases científicas para sua utilização não estejam bem estabelecidas. Este estudo analisou os efeitos do ultra som na cicatrização de tendões flexores de coelhos após tenorrafia. Foram utilizados 30 coelhos da raça Nova Zelândia, com peso médio de 2,7 Kg, divididos em dois grupos de 15 animais submetidos a tenotomia e tenorrafia com sutura tipo Kessler do tendão flexor profundo do terceiro dedo da pata dianteira direita. Após 24 horas foi iniciado em um dos grupos tratamento

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24

Gilday, Steven. "The Therapeutic Potential of Indian Hedgehog (Ihh) for Tendon-to-Bone Repair." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460731518.

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25

Cao, Yi, and 曹怡. "Investigation of expression of extracellular matrix component genes during tendon healing process: an in vivochicken study." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42182414.

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26

Louie, Libby K. "Effect of a porous collagen-glycosaminoglycan copolymer on early tendon healing in a novel animal model." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/43367.

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27

Estrada, Roberto J. [Verfasser]. "Healing Characterization of Surgically Induced Core Lesions of the Equine Superficial Digital Flexor Tendon / Roberto J. Estrada." Berlin : Freie Universität Berlin, 2014. http://d-nb.info/106036784X/34.

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28

Cao, Yi. "Investigation of expression of extracellular matrix component genes during tendon healing process an in vivo chicken study /." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42182414.

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29

Pasternak, Björn. "Towards surgical use of matrix metalloproteinase biology /." Linköping : Department of Clinical and Experimental Medicine, Linköping University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11489.

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30

Romano, Cristiane Vitaliano Graminha. "Os efeitos do ultra-som terapêutico aplicado na fase precoce da cicatrização do tendão flexor. estudo biomecânico em tendões de coelho." Universidade de São Paulo, 2001. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-12092001-093542/.

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Foi realizado um estudo experimental dos efeitos do ultra-som terapêutico sobre a resistência à tração de tendões flexores em cicatrização, usando o tendão flexor dos dedos de coelho como modelo. Foram utilizados 25 coelhos fêmea, da raça Nova Zelândia, adultos jovens de 3 Kg de peso corporal médio. Todos os animais foram operados sob anestesia geral para terem o tendão flexor profundo do terceiro dedo da pata dianteira direita seccionado e imediatamente reparado com a técnica de Kessler. As patas operadas eram imobilizadas com uma órtese de material termoplástico durante todo o período do exp

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31

Empson, Yvonne Marie. "Developing a Living Composite Ligament by Combining Prolotherapy and Nanoparticles as Treatment for Damaged Connective Tissue." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/78114.

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Significant cost and debilitation results from connective tissue injury and disease every year. Prolotherapy is an effective medical treatment used to increase joint stability. However, most associated studies are retrospective or case studies, rather than comprehensive laboratory investigation originating with the cellular response to exposure to the proliferant solutions. As a parallel consideration, nanoparticles are being investigated for use in drug delivery and heat shock treatment of cancerous tissue due to their unique structural and thermal properties. The phenomenal strength and stif

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32

Bastos, Jessica Lucia Neves. "Estudo comparativo de sistemas a base de lasers, leds e ultra-som (US) de baixa intensidade no reparo tecidual em tendão calcâneo." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-16102008-121005/.

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Um dos recursos mais utilizados no processo de reparo de lesões tendíneas é o laser que demonstrou ter resultados satisfatórios quando se buscam efeitos antiinflamatório e cicatrizante. No entanto, por requerer uma tecnologia de alto custo, um outro tipo de fototerapia vem sendo buscado, como o diodo emissor de luz, LED. Porém, o número de pesquisas realizadas para a determinação segura de seus efeitos terapêuticos ainda é muito pequeno, inviabilizando uma proposta de protocolo para adoção do LED. Um outro recurso também utilizado durante a reabilitação de lesões tendíneas, é o ultra-som pulsa

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33

Gaut, Ludovic. "Mechanical and molecular signals underlying tendon cell differentiation." Electronic Thesis or Diss., Sorbonne université, 2018. http://www.theses.fr/2018SORUS301.

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Les tendons sont une forme unique de tissu conjonctif au sein du système musculosquelettique. Le développement, l’homéostasie et la réparation du tendon reposent sur des combinaisons de paramètres moléculaires et aussi mécaniques, régulant la production et l’assemblage des fibres de collagène. Notre objectif est de comprendre quelles sont les voies de mécanotransduction impliquées dans la différentiation tendineuse, via deux (co-)facteurs de transcription : EGR1 et YAP. Nous avons montré que l’expression du gène de tendon SCX, de EGR1 et l'activité de YAP sont réduites dans les tendons de memb

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34

Chokalingam, Kumar. "Transgenic Mouse Model: Examination of Healing, Development and Mechanical Response of Cells." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1259076989.

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35

Lin, Dasheng [Verfasser], and Denitsa [Akademischer Betreuer] Docheva. "Unravelling the roles of tenomodulin at the nexus of early tendon healing and intervertebral disc homeostasis / Dasheng Lin ; Betreuer: Denitsa Docheva." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1222909154/34.

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36

Hsieh, Chi-Fen [Verfasser], and Denitsa [Akademischer Betreuer] Docheva. "Advancing tendon healing by scaffolds-free delivery of different subtypes of mesenchymal stem or progenitor cells / Chi-Fen Hsieh ; Betreuer: Denitsa Docheva." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1158496095/34.

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37

Seto, Song P. "The development of heparin-based materials for tissue engineering applications to treat rotator cuff tendon injuries." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/51898.

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Surgical repair of torn rotator cuff tendons have a high rate of failure and does not address the underlying pathophysiology. Tissue engineering strategies, employing the use of multipotent progenitor cells or growth factors, represent potential therapies to improve the outcome of rotator cuff surgery. The use of glycosaminoglycan-based biomaterials in these therapies may enhance the effectiveness of cell and growth factor delivery techniques. Furthermore, understanding the cellular and molecular mediators in tendon overuse can help elucidate the causes of tendon degeneration. Thus the overall

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Aro, Andrea Aparecida de 1980. "Efeito dos extratos de Aloe vera e Arrabidaea chica sobre a cicatrização do tendão calcanear de ratos após transecção parcial." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317389.

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Orientador: Edson Rosa Pimentel<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-21T05:39:03Z (GMT). No. of bitstreams: 1 Aro_AndreaAparecidade_D.pdf: 5514361 bytes, checksum: 938312e7fcf5c6bdd9bba11064c61b15 (MD5) Previous issue date: 2012<br>Resumo: A utilização de extratos vegetais com atividades farmacológicas pode ser promissora no tratamento de lesões tendíneas, considerando a presença de princípios ativos que estimulam a síntese de componentes da matriz extracelular (MEC). Portanto, o presente estudo teve como objeti

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Riley, Christopher Bruce. "Intrinsic healing in the equine superficial digital flexor tendon in vitro, effects of hyaluronate and polysulfated glycosaminoglycans on matrix synthesis and cell proliferation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ27427.pdf.

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Farcic, Thiago Saikali. "Efeitos de diferentes tempos de aplicação do ultrassom terapêutico no tratamento de tendão de ratos no processo de reparação tecidual." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5163/tde-03012012-080324/.

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O objetivo deste estudo foi avaliar o efeito de diferentes tempos de tratamento do ultrassom terapêutico na cicatrização de lesão tendínea. Quarenta ratos machos Wistar (300 ± 45g), dos quais 32 sofreram tenotomia do tendão do calcâneo, foram divididos em 5 grupos: grupo C, sem tenotomia e tratamento, grupo T, com tenotomia e sem tratamento, US1,US2 e US3 submetidos à tenotomia e tratados com UST nos tempos de 1, 2 e 3 minutos por área de transdutor. Os animais foram mortos no 12º dia pósoperatório e os tendões retirados cirurgicamente para análise da organização das fibras colágenas utilizou-

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Chapman-Jones, David. "The Achilles tendon : an evaluation of the healing processes occuring with chronic pathology : using a prospective comparison study of conservative treatment regimes and micro-current application." Thesis, City University London, 1998. http://openaccess.city.ac.uk/7568/.

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Muscles enable the skeleton to move. Muscles are attached to bones via tendons. Inappropriate stress placed upon the muscular-skeletal system, for example sporting activities for which the subject Is untrained, can result in Injuries which may occur either in the muscle, muscle-tendinous junction or the tendon tissue itself. The resultant pathology can often result in loss of strength or pain in the area. The healing processes of tendon tissue are not well understood and the difficulty In the clinical management of pathology reflects this. Current treatment of this type of Injury Is dependent

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Almeida, Marcos dos Santos de 1980. "O efeito da eletroacupuntura nos pontos Zusanli (E-36) e Chengshan (B-57) sobre o processo de cicatrização do tendão calcâneo de ratos após tenotomia parcial = uma análise bioquímica e morfológica." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317411.

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Orientador: Edson Rosa Pimentel<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-17T20:40:15Z (GMT). No. of bitstreams: 1 Almeida_MarcosdosSantosde_M.pdf: 1553509 bytes, checksum: 83b5ab6bad050eff3b5f36b0524643b3 (MD5) Previous issue date: 2011<br>Resumo: A eletroacupuntura (EA) tem sido utilizada amplamente para o tratamento de uma variedade de doenças inflamatórias e para o alivio da dor. No entanto, não há relatos na literatura sobre o efeito da EA na composição e organização da matriz extracelular (MEC) de tendões

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Guerra, Flavia Da Ré 1984. "Efeito de diferentes protocolos de laser de baixa potência sobre a cicatrização do tendão calcanear de ratos após transecção parcial = Effect of different protocols of low-power laser on the healing of rats Achilles tendon after partial transection." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317367.

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Orientador: Edson Rosa Pimentel<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-23T11:50:11Z (GMT). No. of bitstreams: 1 Guerra_FlaviaDaRe_D.pdf: 2578763 bytes, checksum: 4d00d5fa99bb0b97be32b1a4af7e825a (MD5) Previous issue date: 2013<br>Resumo: O tendão calcanear é o tendão mais acometido por ruptura, particularmente em atividades esportivas. O processo de cicatrização resulta em uma matriz extracelular (MEC) menos organizada o que reduz sua resistência à tensão e torna-o mais susceptível à recorrência de lesões. A terap

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44

Pasternak, Björn. "Towards surgical use of matrix metalloproteinase biology." Doctoral thesis, Linköpings universitet, Ortopedi och idrottsmedicin, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11489.

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Matrix metalloproteinases (MMPs), such as collagenases, are a family of enzymes capable of degrading most constituents of the extracellular matrix. MMPs are thought to be involved in the aetiopathogenesis of tendon rupture. Additionally, failure of healing has in some instances been associated with elevated levels of MMPs. We have studied (a) the effects of the MMP-inhibitor doxycycline on healing of tendons and intestines in experimental models and (b) systemic levels of MMPs and their endogenous inhibitors (TIMPs) in patients with tendon rupture. In the first study, systemic doxycycline trea

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Kuang, Guanming, and 邝冠明. "Preparation of a strontium enriched calcium phosphate cement and its use in accelerating the healing of a soft tissue tendon graft within the bone tunnel in a rabbit anterior cruciate ligament reconstruction model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/193043.

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Anterior cruciate ligament (ACL) rupture is a major clinical problem in sports medicine. The current mainstay of treatment is arthroscopic-assisted ACL reconstruction with a soft tissue tendon graft. However, the affected patients are required to abstain from any pivoting activity for at least six to nine months after the operation to protect the graft-host bone interface in order to allow the graft to heal. In this study, a method to accelerate the graft healing within the bone tunnel is proposed by using a local application of an osteoconductive bone cement (Strontium enriched calcium pho

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Barbato, Kelly Biancardini Gomes. "Efeitos do uso de antiinflamatório e do exercício aeróbico sobre a regeneração tecidual e perfil biomecânico do tendão calcâneo de ratos após ruptura completa." Universidade do Estado do Rio de Janeiro, 2011. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=3845.

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Ruptura do tendão calcâneo é uma das lesões tendíneas mais frequentes. Embora a maioria dos trabalhos sugira que o exercício seja benéfico na cicatrização tendínea, não há consenso sobre o efeito do antiinflamatório neste contexto. Trabalhos experimentais tentam reproduzir lesão aguda deste tendão, em diferentes espécies animais. Neste estudo, descrevemos uma técnica de tenotomia completa do tendão calcâneo direito em ratos e, em seguida, avaliamos os efeitos do uso do antiinflamatório e do exercício aeróbico, isoladamente e em combinação, sobre a proliferação celular e o perfil biomecânico do

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Eliasson, Pernilla. "Response to mechanical loading in healing tendons." Doctoral thesis, Linköpings universitet, Ortopedi och idrottsmedicin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-70774.

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Ruptured tendons heal faster if they are exposed to mechanical loading. Loading creates deformation of the extracellular matrix and cells, which give rise to intracellular signalling, increased gene expression and protein synthesis. The effects of loading have been extensively studied in vitro, and in intact tendons in vivo. However, the response to loading in healing tendons is less known. The general aim of this thesis was to understand more about the response to mechanical loading during tendon healing. The specific aims were to find out how short daily loading episodes could influence tend

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Cumming, Benjamin Donald. "A mathematical model of wound healing and subsequent scarring." Queensland University of Technology, 2006. http://eprints.qut.edu.au/16300/.

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Wound healing is governed by a complex cascade of related processes, involving cells, extracellular matrix and cytokines. In adults this always results in a scar whilst embryonic wound healing is scarless and extensive research worldwide is aimed at reducing scarring in adults. A mathematical framework for problems in dermal wound healing is developed that incorporates models of the individual processes involved. Cells are modelled as discrete individuals. Cytokines and other biologically active factors are modelled as continua. A novel tensorial approach is taken to modelling the extracellul

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Dahlmann, Annegret Hella. "The effects of growth factors and mechanical tension on ocular fibroblasts in wound healing and scarring." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444597/.

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Processes of wound healing or scarring cause many blinding eye conditions and can limit the success of surgical eye treatments. The mechanisms underlying matrix remodelling and contraction by connective tissue cells (fibroblasts) are not fully understood. Two main theories dominate the field: firstly, that fibroblasts in a wound begin to express alpha smooth muscle actin and transdifferentiate into myofibroblasts with enhanced contractile properties, and secondly that fibroblast migration might underly matrix condensation. The purpose of this work was to develop novel imaging techniques to inv

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Petersson, Ludvig. "The Roles of Growth Factor Interactions and Mechanical Tension in Angiogenesis." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-113238.

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Angiogenesis, the formation of new blood vessels from preexisting ones through creation of new vessel branch points by sprouting or vessel splitting, is an important part of tissue growth in both physiological processes like wound healing and pathological conditions such as cancer. Growth factors like VEGF-A, FGF-2 and PDGF-BB are involved in both types of angiogenesis. Screening for genes regulated by VEGF-A stimulation in endothelial cells revealed up regulation of the endothelial cell specific glycoprotein endocan. Endocan itself did not stimulate angiogenesis. VEGF was a specific inducer s

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