Dissertations / Theses on the topic 'Temporal lobes'
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Hill, Vicky. "Memory function in the temporal lobes." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300138.
Full textBohbot, Veronique Deborah 1969. "The medial temporal lobes and human memory." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/288748.
Full textJean, Stéphane. "Présentation itérative de la figure complexe de Rey : étude des capacités d'apprentissage visuo-perceptives de deux adultes porteurs d'une lésion frontale hémisphérique droite /." Thèse, Chicoutimi : Université du Québec à Chicoutimi, 2002. http://www.uqtr.ca/biblio/notice/resume/17751318R.html.
Full textEn tête du titre : Université du Québec, mémoire présenté comme exigence partielle de la maîtrise en psychologie offerte à l'Université du Québec à Chicoutimi en vertu d'un protocole d'entente avec l'Université du Québec à Trois-Rivières. CaQTU Comprend des réf. bibliogr. : p. 106-116.
Tremblay, Karine. "Mesure de l'apprentissage en mémoire visuelle selon une méthode itérative de présentation de la figure complexe de Rey chez des adultes porteurs d'une lésion temporale droite /." Thèse, Chicoutimi : Université du Québec à Chicoutimi, 2002. http://theses.uqac.ca.
Full textHo, Nim-chee Annie. "Neuropsychological functioning after temporal lobectomy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B29725537.
Full textCrane, Joelle. "Right medial temporal-lobe contribution to object-location memory." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36571.
Full textNichols, Elizabeth Anne. "Involvement of the medial temporal lobes in working memory /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Full textVisser, Maya. "Semantic memory and the role of the anterior temporal lobes." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.525171.
Full textWalker, Sarah Joanne. "Exploring the role of the temporal lobes in relational memory." Thesis, University of Southampton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398719.
Full textThaiss, Laila Maria. "A comparison of the role of the frontal cortex and the anterior temporal lobe in source memory and in the accurate retrieval of episodic information /." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38424.
Full textIn the present experiments, patients with unilateral excisions restricted to frontal cortex or to the anterior temporal lobe were compared on various tasks examining source memory performance and the accurate retrieval of episodic information. The results of these studies failed to support the general contention that patients with frontal cortex excisions have source (or temporal context) memory impairments. Instead, differences between these patients and normal control subjects appeared to be contingent on whether strategic organizational or control processes were necessary for efficient processing of episodic information. The memory of patients with left temporal lobe excisions, on the other hand, was significantly impaired for both content and source information in most tasks. Furthermore, these subjects showed high rates of inaccuracies and distortions of memory. The false memories of this patient group were attributed to a combination of their poor memory for the specific items of the task and their over-reliance on semantic "gist" or on inferential knowledge about the events. Patients with right temporal lobe excisions were generally less severely impaired on the verbal memory tasks compared with those with left-sided lesions, but were impaired in their memory for the contextual aspects of an event.
Salmond, Claire Helen. "Investigations into the role of the medial temporal lobes in autism." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252264.
Full textCollins, Jessica Ann. "Beyond the FFA: Understanding Face Representation within the Anterior Temporal Lobes." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/255610.
Full textPh.D.
Extensive research has supported the existence of a specialized face-processing network that is distinct from the visual processing areas used for general object recognition. The majority of this work has been aimed at characterizing the response properties of the fusiform face area (FFA) and the occipital face area (OFA), which together are thought to constitute the core network of brain areas responsible for facial identification. Although accruing evidence has shown that face-selective patches in the ventral anterior temporal lobes (vATLs), within perirhinal cortex, play a necessary role in facial identification, the relative contribution of these brain areas to the core face-processing network has remained unarticulated. The current study assessed the relative sensitivity of the anterior face patch, the OFA, and the FFA, to different aspects of person information. Participants learned to associate a name and occupation label, or a name only, with different facial identities. The sensitivity of the face processing areas to facial identity, occupation, and the amount of information associated with a face was then assessed. The results of a multivoxel pattern analysis (MVPA) revealed that distributed activity patterns in the anterior face patch contained information about facial identity, occupation, and the amount of information associated with a face, with the sensitivity of the anterior face patch to occupation and amount of information being greater than the more posterior face processing regions. When a similar analysis was conducted that included all voxels in the perirhinal cortex, sensitivity to every aspect of person information increased. These results suggest that the human ventral anterior temporal lobes may be critically involved in representing social, categorical, information about individual identities.
Temple University--Theses
Samson, Séverine. "Contribution of the left and the right temporal lobes to melodic memory and perception." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74266.
Full textGoddard, Matthew John, and n/a. "Cognitive and emotional effects of vestibular damage in rats and their medial temporal lobe substrates." University of Otago. Department of Pharmacology & Toxicology, 2008. http://adt.otago.ac.nz./public/adt-NZDU20080923.091605.
Full textPigott, Susan. "Visual pattern memory after unilateral anterior temporal lobectomy." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74287.
Full textFrisk, Virginia. "Comprehension and recall of stories following left temporal lobectomy." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75938.
Full textBisbee, Molly. "The Role of the Medial Temporal Lobes in Older Adults' Associative Deficit: A Behavioral Study." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/228468.
Full textWallis, Guy. "Neural mechanisms underlying processing in the visual areas of the occipital and temporal lobes." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259854.
Full textWais, Peter Edward. "The roles of the hippocampus in recognition memory." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3315575.
Full textTitle from first page of PDF file (viewed September 3, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 128-137).
Smith, Mary Louise. "Memory for spacial location and frequency of occurrence after frontal or temporal lobectomy in man." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=72054.
Full textDavidson, Lara. "Neurobiology of the frontal and temporal lobes in schizophrenia, a meta-analytic review of neuroimaging and neuropathological findings." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ56170.pdf.
Full textRice, Grace. "Using neuroimaging and transcranial magnetic stimulation to probe conceptual knowledge in the left and right anterior temporal lobes." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/using-neuroimaging-and-transcranial-magnetic-stimulation-to-probe-conceptual-knowledge-in-the-left-and-right-anterior-temporal-lobes(b834299d-8650-4c7e-89f9-0c503ce64868).html.
Full textMayberry, Emily Jane. "Exploring conceptual knowledge and name relearning in semantic dementia." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/exploring-conceptual-knowledge-and-name-relearning-in-semantic-dementia(f82024ef-eb65-48b3-93b7-da4f13662315).html.
Full textKemper, Birgit. "Neuropsychologische Untersuchung bei Frontallappenepilepsien ein Vergleich kognitiver Leistungen zwischen Patienten mit Frontal- und Temporallappenepilepsie im Rahmen der prächirurgischen Diagnostik /." Münster : Universität Münster, 1995. http://catalog.hathitrust.org/api/volumes/oclc/64528329.html.
Full textFALLON, PHILIPPE. "Meningo-encephalocele du lobe temporal prolabee dans la fosse pterygo-maxillaire." Lille 2, 1992. http://www.theses.fr/1992LIL2M162.
Full textVoirin, Jimmy Auque Jean. "La chirurgie de la face antéro-interne du lobe temporal dans le traitement de l'épilepsie temporo-mésiale pharmaco-résistante étude rétrospective de 42 patients /." [S.l] : [s.n], 2005. http://www.scd.uhp-nancy.fr/docnum/SCDMED_T_2005_VOIRIN_JIMMY.pdf.
Full textBethmann, Anja. "Die supramodale Verarbeitung individueller Konzepte am Beispiel menschlicher Stimmen und visuell präsentierter Comicfiguren : eine fMRT-Studie der Temporallappen." Phd thesis, Universität Potsdam, 2012. http://opus.kobv.de/ubp/volltexte/2012/5985/.
Full textIt is assumed that neural pathways run from the primary sensory cortices through the temporal lobes towards their poles crossing areas necessary for object recognition. Especially the most anterior temporal parts were associated with processes contributing to the identification of objects. Yet, there is little agreement on the kinds of objects that are interpreted by the anterior temporal lobes. For example, there are assumptions regarding linguistic processing, voice recognition, the processing of general semantic information or the identification of unique entities. In order to differentiate between those theories, four event-related fMRI experiments were performed in healthy young adults. In three experiments, the subjects heard the voices of famous and unknown persons. In addition, characteristic sounds of animals and musical instruments were presented in one of these experiments. During the fourth experiment, drawings of famous cartoon characters were shown together with animals and fruit & vegetables. The neural activity in response to these stimuli compared to rest was analyzed using a regions-of-interest approach. 12 regions-of-interest that covered the majority of the temporal lobes were defined in each hemisphere. Both with auditory and visual stimuli, there were clear activation differences between the semantic categories in the anterior temporal lobes. Unique entities (human voices and cartoon characters) evoked a significantly stronger signal than categorical concepts (animals, musical instruments, fruit & vegetables). Furthermore, the signal in response to voices of familiar persons was significantly higher than to unfamiliar voices. Thus, the results are most compatible with the assumption that the anterior temporal lobes process supramodal features of familiar unique entities. As the before-mentioned signal differences between unique and categorical concepts and between familiar and unfamiliar voices increased from the transversal temporal gyri towards the temporal poles, the results support the notion of a ventral processing pathway running rostrally through the temporal lobes. In accordance with the convergence zone theory described by A.R. Damasio, the precise function of that pathway seems to consist in the incremental combination of sensorimotor concept features. Since familiar unique entities possess an especially high number of features, their processing was found to be directed into more anterior portions of the temporal lobe than the perception of unfamiliar or categorical concepts.
Ehrlé, Nathalie. "Traitement temporel de l'information auditive et temporal." Reims, 1998. http://www.theses.fr/1998REIML009.
Full textDinkelacker, Vera. "Network pathology in temporal lobe epilepsy." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066156/document.
Full textOur vision of temporal lobe epilepsy (TLE) with hippocampal sclerosis has much evolved in recent years. Initially regarded as a disease centered on a single lesion, it is now perceived as a genuine network disease, which we intended to explore with a multimodal approach. We examined structural connectivity, fMRI, EEG and cognitive dysfunction in a cohort of 44 patients with unilateral hippocampal sclerosis (HS, 22 with right, 22 with left HS) and 28 healthy age and gender matched control participants. Cortical regions of interest and hippocampal volumes were determined with Freesurfer, structural connectivity with MRtrix (pairwise disconnections and component effects with Network Based Statistics), or for hippocampal-thalamic connections with FSL. We found a pronounced pattern of disconnections most notably in the left hemisphere of patients with left TLE. Network Based Statistics showed large bi hemispheric clusters lateralized to the diseased side in both left and right temporal lobe epilepsy. We suggest that hippocampal sclerosis is associated with widespread disconnections if situated in the dominant hemisphere. We then determined streamline connections between hippocampus and thalamus and found an increase in connections in relation to the HS. This increase was seemingly dysfunctional as the number of hippocampal-thalamic connections was negatively correlated with performance in executive tasks. EEG analysis revealed predominantly ipsilateral epileptic discharge. The number of sharp waves was highly correlated with a number of executive functions depending on the frontal lobe, hence at distance of the HS. Our data thus confirms the concept of temporal lobe epilepsy as a network disease that finds its expression both in widespread, though lateralized alterations of structural connectivity and in neuropsychological dysfunction way beyond the hippocampus
Tramoni, Eve. "Approche neuropsychologique des bases anatomo-fonctionnelles de la mémoire relationnelle." Aix-Marseille 2, 2009. http://www.theses.fr/2009AIX20665.
Full textShrager, Yael. "Human declarative memory and the medial temporal lobe evidence from patients with medial temporal lobe lesions /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3306982.
Full textTitle from first page of PDF file (viewed July 1, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 63-68).
Lippincott, Cynthia E. Williams J. Michael. "An investigation of extra-temporal deficits in temporal lobe epilepsy /." Philadelphia, Pa. : Drexel University, 2010. http://hdl.handle.net/1860/3269.
Full textBenini, Ruba Sayed. "GABAergic signalling in temporal lobe epilepsy." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111818.
Full textMorgan, Lisa. "Social cognition in temporal lobe epilepsy." Thesis, University of East London, 2011. http://roar.uel.ac.uk/3675/.
Full textBuck, Sarah. "Memory in paediatric temporal lobe epilepsy." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10057610/.
Full textArcot, Desai Sharanya. "Multielectrode microstimulation for temporal lobe epilepsy." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/50384.
Full textSidhu, M. K. "Episodic memory in temporal lobe epilepsy." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1471130/.
Full textRondouin, Gérard. "L'épilepsie du lobe temporal : approche expérimentale." Montpellier 1, 1991. http://www.theses.fr/1991MON11251.
Full textTesta, S. Marc. "DEPRESSIVE SYMPTOMS IN TEMPORAL LOBE EPILEPSY." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin997801556.
Full textPeret, Angelique. "Rôle des récepteurs Kaïnate dans la physiopathologie de l'épilepsie du lobe temporal." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4068.
Full textKainate is a potent neurotoxin known to induce acute seizures. However, whether kainate receptors play any role in the pathophysiology of temporal lobe epilepsy (TLE) is not yet known. In animal models of chronic epilepsy, as in human TLE, the hippocampus displays major network reorganization. In particular, sprouting of hippocampal mossy fibers leads to the formation of powerful recurrent excitatory circuits among dentate granule cells, which partly accounts for the enhanced ability of the hippocampus to generate epileptiform activity in human patients and animal models of TLE. At the aberrant recurrent excitatory synapses, mossy fiber inputs impinging on dentate granule cells operate mostly via ectopic kainate receptors and drive synaptic events with abnormal long lasting kinetics not present in naïve conditions. The goal of this work was to explore the pathophysiological implications of kainate receptors in generation of recurrent seizure in TLE through the use of kainate receptors subunit deficient mice and selected pharmacological agents. In an animal model of TLE, we observed a strong reduction of both interictal and ictal activities in the dentate gyrus in vitro and in vivo, in mice lacking the GluK2 subunit, and through the application of a pharmacological agent inhibiting GluK2/GluK5 receptors. Therefore, we demonstrate that aberrant GluK2-containing kainate receptors contribute to chronic seizures in TLE, urging for the development of antiepileptic strategies targeting these receptors
Alonso, Fernández Irene. "The role of the medial temporal lobe in binding lyrics and melodies : a neuropsychological and neuroimaging approach." Thesis, Lille 3, 2015. http://www.theses.fr/2015LIL30009/document.
Full textSongs naturally couple music with language, constituting one of the most broadly used forms of music expression. Interestingly, songs require the simultaneous and integrated process of verbal (lyrics) and musical (melody) information to form a single memory trace. The medial temporal lobe has been identified as the key region for the integration of features of an event in episodic memory, also called the binding function. Nevertheless, the mechanisms by which the brain binds lyrics and melodies in song memory remain poorly understood. The purpose of this thesis is to elucidate the role of the MTL on the binding of lyrics and melodies for the creation of a unified song memory trace. First, the effects of unilateral hippocampus sclerosis on song processing were investigated in an fMR-adaptation study (Study 1). Patients with left hippocampal sclerosis showed adaptation deficits in response to lyrics as well as to the integrated representation of songs. To further explore the relation of these results with the emergence of memory for songs, the functional architecture of song memory was examined in a subsequent memory fMRI study (Study 2). The results support the implication of the hippocampus in song binding. Furthermore, the role of other structures, including the Inferior Frontal Gyrus (IFG), the Basal Ganglia (BG) and cerebellum was highlighted and discussed. Finally, Study 2 was adapted to test binding in patients following a unilateral temporal lobe excision for the relief of intractable temporal lobe epilepsy behaviorally in Study 3. Memory for lyrics as well for their melodic context was tested in an explicit recognition task. A strong deficit in lyrics recognition was found in patients with a left temporal lesion, and to a smaller degree in patients with a right temporal lesion. This deficit was correlated with deficits in verbal memory. Evidence from Study 3 further suggests that MTL structures may be crucial for encoding the detailed binding of lyrics with their melodic context, whereas implicit effects of an integrated representation of the song may be spared after MTL lesions. Altogether the studies presented in this thesis provide novel evidence for the role of the medial temporal lobe structures in binding lyrics and melodies for song memory. The present thesis proposes a comprehensive network of cortical and subcortical regions cooperating to successfully encode new songs. Finally, theoretical and clinical implications of these findings are considered
Gibb, Catherine Elizabeth. "Temporal lobe epilepsy : the effects on language." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362519.
Full textFischer, Mark. "Working Memory Intervention in Temporal Lobe Epilepsy." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1447689793.
Full textSheilabi, Marim Abdelghani. "Studies of biomarkers in temporal lobe epilepsy." Thesis, Sheffield Hallam University, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.713507.
Full textBrowne, Georgina Emily. "Nonverbal memory assessment in temporal lobe epilepsy." Thesis, University of East Anglia, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429590.
Full textBonelli-Nauer, S. B. "Cognitive functional MRI in temporal lobe epilepsy." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1455537/.
Full textKourdougli, Nazim. "Hippocampal structural reactive plasticity in a rat model of temporal lobe epilepsy : chloride homeostasis as a keystone." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4091.
Full textThe present dissertation undertakes to investigate the early triggering events of the mossy fiber sprouting (MFS) in the dentate gyrus, a hallmark of hippocampal reactive plasticity in Temporal Lobe Epilepsy (TLE). We used the rat pilocarpine model of TLE to show that altered GABAA receptor-mediated transmission play a key role in the formation of early ectopic MFS during epileptogenesis. This is likely due to a compromised chloride homeostasis, as a result of increased expression of chloride loader NKCC1 and downregulation of the neuronal chloride extruder KCC2. We next addressed the mechanistic action of depolarizing GABAAR responses with regard to neurotrophin signaling. Our findings uncovered that the pan neurotrophin receptor p75 (p75NTR) mediated the sculpting action of depolarizing GABAAR responses on the ectopic MFS. Blockade of depolarizing GABAAR responses using the loop diuretic bumetanide reduced abnormal p75NTR subsequently decreased the ectopic MFS. Finally, transitory application of bumetanide during epileptogenesis resulted in reduction of spontaneous and recurrent seizures during the chronic phase of TLE. The rationale of this work is that unveiling the molecular mechanisms underlying the hippocampal post-seizure glutamatergic network rewiring will help to drive future novel therapeutic avenues involving chloride homeostasis and neurotrophin interplay. Overall, this dissertation shed a new light on how GABAergic transmission and neurotrophin signaling crosstalk can orchestrate reactive hippocampal plasticity in TLE
Amorim, Barbara Juarez. "Analise estatistica baseada em voxel do SPECT cerebral em pacientes com epilepsia de lobo temporal." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313716.
Full textTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: O statistical parametric mapping (SPM) é uma ferramenta de quantificação que tem sido usada no SPECT de perfusão cerebral (SPECT), mas apenas poucos trabalhos na literatura comparam a sua sensibilidade com a da análise visual em pacientes com epilepsia de lobo temporal (ELT) OBJETIVO: Avaliar a capacidade da análise com SPM no SPECT em detectar o foco epileptogênico e alterações perfusionais em regiões extra-temporais em pacientes com epilepsia de lobo temporal mesial (ELTM), comparando os seus achados com os da análise visual MÉTODOS: Foram realizados SPECTs ictal e interictal em 22 pacientes com ELTM refratários ao tratamento clínico. O lado do foco epileptogênico foi definido com base na história clínica, ressonância magnética, eletroencefaiogramas seriados e telemetria. Os SPECTs foram submetidos à análise visual sendo que os SPECTs interictal e ictal foram analisados em conjunto pelos observadores (SPECT-visual-inter e SPECT-visual-ictal). Foi aplicado o SPM2 que comparou os pacientes com um grupo controle de 50 indivíduos normais. No SPM foram realizadas as seguintes comparações: grupo de SPECT interictal com o grupo controle (SPM-grupo-inter); SPECT interictal de cada paciente com o grupo controle (SPM-indiv-inter); grupo de SPECT ictal com o grupo controle (SPM-grupo-ictal); SPECT ictal de cada paciente com o grupo controle (SPM-indiv-ictal). Foram também comparadas as intensidades das alterações perfusionais nos lobos temporais procurando-se por um aumento da perfusão no SPECT ictal em relação ao interictal (SPM-indiv-ictal/inter). RESULTADOS: Não foi observada nenhuma alteração perfusional significativa no SPM-grupo-inter Já no SPM-grupo-ictal o foco epileptogênico foi a região de hiperperfusão mais significativa No SPM-indiv-inter a sensibilidade na localização do foco foi de 45% e no SPM-indiv-ictal a sensibilidade foi de 64%. O SPM-indiv-ictal/inter apresentou a maior sensibilidade para detectar o foco dentre as análises realizadas no SPM (77%) A sensibilidade do SPECT-visual-inter foi de 68% e para o SPECT-visuai-ictal foi de 100%. Por outro lado, diversas áreas de hiperperfusão e hipoperfusão à distância no SPECT ictal foram detectadas principalmente com o SPM CONCLUSÃO: O SPM é uma ferramenta que não depende do operador e é capaz de demonstrar mais áreas de alteração perfusional à distância do foco epileptogênico do que a análise visual. Ele pode ajudar a entender melhor a patofisiologia das crises epilépticas em pacientes com ELTM estudando a relação das diferentes regiões corticais e subcorticais na gênese e na propagação das crises parciais. Entretanto, essa ferramenta não acrescentou um aumento na sensibilidade na localização do foco epileptogênico em relação á análise visual, tanto do SPECT interictal quanto do SPECT ictal
Abstract: Statistical parametric mapping (SPM) is a quantitative tool which has been used in the brain perfusion SPECT (SPECT) However, few works in literature compare its sensitivity with the visual analysis in patients with temporal lobe epilepsy (TLE). PURPOSE: To investigate the capability of SPM analysis in SPECT to detect the epileptogenic focus and distant perfusion abnormalities in patients with mesial temporal lobe epilepsy (MTLE) and to compare these findings to the visual analysis. METHODS: Interictal and ictal SPECTs of 22 patients with refractory MTLE were performed. Epileptic foci were determined based on clinical history, magnetic resonance, electroencephalograms (EEG) and ictal video-EEG. SPECTs were submitted to visual analysis. Ictal and interictal SPECTs were analyzed together by the nuclear physicians (SPECT-visual-inter and SPECT-visual-ictal). It was also performed the SPM2 analysis which used a control group composed of 50 volunteers. The following comparisons were performed in SPM: interictal SPECT group with control group (SPM-group-inter); interictal SPECT from each patient with control group (SPM-indiv-inter); ictal SPECT group with control group (SPM-group-ictal), ictal SPECT from each patient with control group (SPM-indiv-ictal). It was also compared the perfusion intensity in temporal lobes looking for an increase in perfusion on ictal SPECT in relation to interictal SPECT (SPM-indiv-ictal/inter). RESULTS: No significant perfusion alterations were observed on SPM-group-inter. On the other hand, the epileptogenic temporal lobe was the region with most significant hypoperfusion on SPM-group-ictal. The sensitivity to localize the focus on SPM-indiv-inter was 45% and on SPM-indiv-ictal was 64%. The SPM-indiv ictal/inter revealed the highest sensitivity among the SPM analysis to detect the focus (77%). The sensitivity of SPECT-visual-inter was 68% and to SPECT-visual-ictal was 100%. On the other hand, several areas of distant hypoperfusion and hypoperfusion were detected mainly with SPM. CONCLUSION: SPM is a tool which does not depend on the operator and can detect more distant perfusion abnormalities than the visual analysis. It can improve the understanding of pathophysiology in seizures of patients with MTLE by studying the relation among different cortical and subcortical areas in the genesis and propagation of partial seizures. However, this tool did not increase the visual analysis sensitivity to localize the epileptogenic focus in interictal SPECT as well as in ictal SPECT
Doutorado
Neurologia
Doutor em Ciências Médicas
Petty, Karen Hammack. "Pediatric temporal lobe epilepsy versus frontal lobe epilepsy : how does cognitive performance differ ? /." Full text available from ProQuest UM Digital Dissertations, 2007. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1414130851&SrchMode=1&sid=2&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1221160824&clientId=22256.
Full textBooth, Michael C. A. "Temporal lobe mechanisms for view-invariant object recognition." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299094.
Full text