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Relevant bibliographies by topics / Temporal lobe epilepsy – Research

Academic literature on the topic 'Temporal lobe epilepsy – Research'

Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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Journal articles on the topic "Temporal lobe epilepsy – Research"

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Halász, Péter. "The medial temporal lobe epilepsy is a bilateral disease – novel aspects." Journal of Epileptology 24, no. 2 (December 1, 2016): 141–55. http://dx.doi.org/10.1515/joepi-2016-0010.

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SummaryIntroduction.Medial temporal lobe epilepsy (MTLE) is the most frequent form of epilepsy in adulthood. It is classified as local/regional epilepsy. However, there is increasing evidence of the involvement of both temporal lobes and this provides abundant arguments to question this view, and consider MTLE as one of the typical bilateral system epilepsies.Aim.To provide a contemporary review of medial temporal lobe epilepsy, discussing the bilateral aspects, with reference to epilepsy surgery.Methods.A literature review and a resume of the author’s own experiences with MTLE patients.Results.Recent electrophysiological and neuroimaging data provide convincing data supporting that MTLE is a bilateral disease. The uni-and bilateral features form a continuum and the participation rate of the two temporal lobes determine course and surgical perspective of the individual patient.Conclusions.The contradictory data of invasive presurgical evaluations of MTLE patients suggest that there need to identify further indicatory markers of bilaterality and thus change the presurgical evaluation from the non-invasive towards the invasive ways. The mechanisms of the interrelationship between the two temporal lobes in MTLE warrants further research.

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Karavayeva, Ye V., A. V. Ostrovskaya, and N. G. Katayeva. "Research of emotional personal sphere and coping strategies of persons with epilepsy." Bulletin of Siberian Medicine 10, no. 2 (April 28, 2011): 116–21. http://dx.doi.org/10.20538/1682-0363-2011-2-116-121.

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This work is devoted to identifying the relationship between disorders of emotional personal sphere of persons with temporal lobe epilepsy and their preferred coping strategies. The objects of the study were 40 people, including 20 patients with verified diagnosis of temporal lobe epilepsy who are treated at the neurological clinic of the Siberian State University. Clinical and psychological method of research included: the study of neurological status, multivariate Personality Inventory FPI, a scale assessing the level of situational anxiety, C. Spielberger and Y. Khanin, research methods coping strategies A. Lazarus. The results obtained in the present study results confirm the need for early detection of affective spectrum disorders in patients with temporal lobe epilepsy. Because of their availability and high levels of lead to a change in methods of coping with stress, this in turn leads to restrictions in the social sphere.

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Illman, Nathan A., Chris R. Butler, Celine Souchay, and Chris J. A. Moulin. "Déjà Experiences in Temporal Lobe Epilepsy." Epilepsy Research and Treatment 2012 (March 20, 2012): 1–15. http://dx.doi.org/10.1155/2012/539567.

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Historically, déjà vu has been linked to seizure activity in temporal lobe epilepsy, and clinical reports suggest that many patients experience the phenomenon as a manifestation of simple partial seizures. We review studies on déjà vu in epilepsy with reference to recent advances in the understanding of déjà vu from a cognitive and neuropsychological standpoint. We propose a decoupled familiarity hypothesis, whereby déjà vu is produced by an erroneous feeling of familiarity which is not in keeping with current cognitive processing. Our hypothesis converges on a parahippocampal dysfunction as the locus of déjà vu experiences. However, several other temporal lobe structures feature in reports of déjà vu in epilepsy. We suggest that some of the inconsistency in the literature derives from a poor classification of the various types of déjà experiences. We propose déjà vu/déjà vécu as one way of understanding déjà experiences more fully. This distinction is based on current models of memory function, where déjà vu is caused by erroneous familiarity and déjà vécu by erroneous recollection. Priorities for future research and clinical issues are discussed.

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Cascino, Gregory D. "Temporal Lobe Epilepsy: More than Hippocampal Pathology." Epilepsy Currents 5, no. 5 (September 2005): 187–89. http://dx.doi.org/10.1111/j.1535-7511.2005.00059.x.

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Voxel-based Morphometry of the Thalamus in Patients with Refractory Medial Temporal Lobe Epilepsy Bonilha L, Rorden C, Castellano G, Cendes F, Li LM Neuroimage 2005;25:1016–1021 Previous research has suggested that patients with refractory medial temporal lobe epilepsy (MTLE) show gray matter atrophy both within the temporal lobes and in the thalamus. However, these studies have not distinguished between different nuclei within the thalamus. We examined whether thalamic atrophy correlates with the nuclei's connections to other regions in the limbic system. T1-weighted MRI scans were obtained from 49 neurologically healthy control subjects and 43 patients diagnosed with chronic refractory MTLE that was unilateral in origin (as measured by ictal EEG and hippocampal atrophy observed on MRI). Measurements of gray matter concentration (GMC) were made by using automated segmentation algorithms. GMC was analyzed both voxel by voxel (preserving spatial precision) as well as using predefined regions of interest. Voxel-based morphometry revealed intense GMC reduction in the anterior portion relative to posterior thalami. Furthermore, thalamic atrophy was greater ipsilateral to the MTLE origin than on the contralateral side. Here we demonstrate that the thalamic atrophy is most intense in the thalamic nuclei that have strong connections with the limbic hippocampus. This finding suggests that thalamic atrophy reflects this region's anatomic and functional association with the limbic system rather than a general vulnerability to damage. Ipsilateral and Contralateral MRI Volumetric Abnormalities in Chronic Unilateral Temporal Lobe Epilepsy and Their Clinical Correlates Seidenberg M, Kelly KG, Parrish J, Geary E, Dow C, Rutecki P, Hermann B Epilepsia 2005;46:420–430 Purpose To assess the presence, extent, and clinical correlates of quantitative MR volumetric abnormalities in ipsilateral and contralateral hippocampus, and temporal and extratemporal lobe regions in unilateral temporal lobe epilepsy (TLE). Methods In total, 34 subjects with unilateral left ( n = 15) or right ( n = 19) TLE were compared with 65 healthy controls. Regions of interest included the ipsilateral and contralateral hippocampus as well as temporal, frontal, parietal, and occipital lobe gray and white matter. Clinical markers of neurodevelopmental insult (initial precipitating insult, early age of recurrent seizures) and chronicity of epilepsy (epilepsy duration, estimated number of lifetime generalized seizures) were related to MR volume abnormalities. Results Quantitative MR abnormalities extend beyond the ipsilateral hippocampus and temporal lobe with extratemporal (frontal and parietal lobe) reductions in cerebral white matter, especially ipsilateral but also contralateral to the side of seizure onset. Volumetric abnormalities in ipsilateral hippocampus and bilateral cerebral white matter are associated with factors related to both the onset and the chronicity of the patients’ epilepsy. Conclusions These cross-sectional findings support the view that volumetric abnormalities in chronic TLE are associated with a combination of neurodevelopmental and progressive effects, characterized by a prominent disruption in ipsilateral hippocampus and neural connectivity (i.e., white matter volume loss) that extends beyond the temporal lobe, affecting both ipsilateral and contralateral hemispheres. MR Volumetric Analysis of the Piriform Cortex and Cortical Amygdala in Drug-refractory Temporal Lobe Epilepsy Gonçalves Pereira PM, Insaustid R, Artacho-Pérulad E, Salmenperäe T, Kälviäinene R, Pitkänen A AJNR Am J Neuroradiol 2005;26:319–332 Purpose The assessment of patients with temporal lobe epilepsy (TLE) traditionally focuses on the hippocampal formation. These patients, however, may have structural abnormalities in other brain areas. Our purpose was to develop a method to measure the combined volume of the human piriform cortex and cortical amygdala (PCA) by using MRI and to investigate PCA atrophy. Methods The definition of anatomic landmarks on MRIs was based on histologic analysis of 23 autopsy control subjects. Thirty-nine adults with chronic TLE and 23 age-matched control subjects were studied. All underwent high-spatial-resolution MRI at 1.5 T, including a tilted T1-weighted 3D dataset. The PCA volumes were compared with the control values and further correlated with hippocampal, amygdale, and entorhinal cortex volumes. Results The normal volume was 530 ± 59 mm3 (422-644) (mean ± 1 SD [range]) on the right and 512 ± 60 mm3 (406-610) on the left PCA (no asymmetry, and no age or sex effect). The intraobserver and interobserver variability were 6% and 8%, respectively. In right TLE patients, the mean right PCA volume was 18% smaller than that in control subjects ( p < 0.001) and 15% smaller than in left TLE ( p < 0.001). In left TLE, the mean left PCA volume was 16% smaller than in control subjects ( p < 0.001) and 19% smaller than in right TLE ( p < 0.001). Overall, 18 (46%) of the 39 patients had a greater than 20% volume reduction in the ipsilateral PCA. Bilateral atrophy was found in 7 (18%) of 39. Patients with hippocampal volumes of at least 2 SDs below the control mean had an 18% reduction in the mean PCA volume compared with patients without hippocampal atrophy ( p < 0.001). Ipsilaterally, hippocampal ( r = 0.756, p < 0.01), amygdaloid ( r = 0.548, p < 0.01), and entorhinal ( r = 0.500, p < 0.01) volumes correlated with the PCA volumes. Conclusions The quantification of PCA volume with MRI showed that the PCA is extensively damaged in chronic TLE patients, particularly in those with hippocampal atrophy.

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Bintoro, Aris Catur, Muhamad Thohar Arifin, Harsono, Amin Husni, Surya Pratama Brilliantika, Yuriz Bakhtiar, Novita Ikbar Khairunnisa, et al. "Transcortical selective amygdalohippocampectomy for intractable mesial temporal lobe epilepsy: a review of outcomes in a single center." Bali Medical Journal 11, no. 3 (November 1, 2022): 1468–75. http://dx.doi.org/10.15562/bmj.v11i3.3475.

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Introduction: Various surgical procedures have been found to effectively treat intractable temporal lobe epilepsy (TLE), including transcortical selective amygdalohippocampectomy (SAH), which is intended to protect the temporal lobe and to prevent interference with vascular structure. This research analyzed the outcome of post-operative seizure-free with transcortical selective amygdalohippocampectomy for intractable mesial temporal lobe epilepsy patients in a minimum two-year follow-up after surgery. Methods: Data of one hundred ninety-two patients who had undergone transcortical selective amygdalohippocampectomy for non-lesional, medically intractable, temporal lobe epilepsy were analyzed. Result: The statistical analysis indicated that Focal to Bilateral Tonic-Clonic Seizure had a more significant outcome (p=0.019) than other seizures. In all research subjects, after three, six, and twelve years of follow-up, the chance for a seizure-free after surgery was respectively 93.2 percent, 67.9 percent, and 36.7 percent with a median average survival period for all subjects of 11.00 years (95 % CI: 8.55 – 13.44) Conclusions: Transcortical selective amygdalohippocampectomy is an effective therapy for intractable mesial temporal lobe epilepsy and provides a satisfactory outcome. The transcortical approach allows an appropriate operative field by careful dissection with limited retraction to eliminate the epileptogenic target while preventing damage to the underlying vascular and cortical structures.

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Scharfman, Helen E. "The Dentate Gyrus and Temporal Lobe Epilepsy: An “Exciting” Era." Epilepsy Currents 19, no. 4 (June 24, 2019): 249–55. http://dx.doi.org/10.1177/1535759719855952.

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This review describes developments in epilepsy research during the last 3 to 4 decades that focused on the dentate gyrus (DG) and its role in temporal lobe epilepsy (TLE). The emphasis is on basic research in laboratory animals and is chronological, starting with hypotheses that attracted a lot of attention in the 1980s. Then experiments are described that addressed the questions, as well as new methods that often made the experiments possible. In addition, where new questions arose and the implications for clinical epilepsy are discussed.

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Chow, Nelson, and Mark Krongold. "Machine Learning: Current Uses in Temporal Lobe Epilepsy." University of Western Ontario Medical Journal 87, no. 2 (March 12, 2019): 15–17. http://dx.doi.org/10.5206/uwomj.v87i2.1164.

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In the era of Big Data, finding patterns amidst large and/or complex datasets is a significant problem, particularly in medicine, such as in neuroscience and neuroimaging. Machine learning techniques are powerful tools with the ability to develop pattern recognition that, once trained, can be utilized to analyze large datasets in research as well as in clinical settings. Temporal lobe epilepsy is a very prominent neuroimaging research subject in which machine learning has been utilized, demonstrating some of its applications in automated labeling of diagnostic imaging, feature classification and feature extraction.

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Shuman, Tristan, Benjamin Amendolara, and Peyman Golshani. "Theta Rhythmopathy as a Cause of Cognitive Disability in TLE." Epilepsy Currents 17, no. 2 (March 2017): 107–11. http://dx.doi.org/10.5698/1535-7511.17.2.107.

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Memory difficulties are commonly associated with temporal lobe epilepsy (TLE) and cause significant disability. This article reviews the role of altered hippocampal theta oscillations and theta-gamma coupling as potential causes of memory disturbance in temporal lobe epilepsy, dissecting the potential mechanisms underlying these changes in large-scale neuronal synchronization. We discuss development of treatments for cognitive dysfunction directed at restoring theta rhythmicity and future directions for research.

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Carne, R. P., M. J. Cook, L. R. MacGregor, C. J. Kilpatrick, R. J. Hicks, and T. J. O’Brien. "“Magnetic Resonance Imaging Negative Positron Emission Tomography Positive” Temporal Lobe Epilepsy: FDG-PET Pattern Differs from Mesial Temporal Lobe Epilepsy." Molecular Imaging and Biology 9, no. 1 (December 19, 2006): 32–42. http://dx.doi.org/10.1007/s11307-006-0073-0.

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Alsemari, Abdulaziz, Faisal Al-Otaibi, Salah Baz, Ibrahim Althubaiti, Hisham Aldhalaan, David MacDonald, Tareq Abalkhail, et al. "Epilepsy Surgery Series: A Study of 502 Consecutive Patients from a Developing Country." Epilepsy Research and Treatment 2014 (January 30, 2014): 1–8. http://dx.doi.org/10.1155/2014/286801.

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Purpose. To review the postoperative seizure outcomes of patients that underwent surgery for epilepsy at King Faisal Specialist Hospital & Research Centre (KFSHRC). Methods. A descriptive retrospective study for 502 patients operated on for medically intractable epilepsy between 1998 and 2012. The surgical outcome was measured using the ILAE criteria. Results. The epilepsy surgery outcome for temporal lobe epilepsy surgery (ILAE classes 1, 2, and 3) at 12, 36, and 60 months is 79.6%, 74.2%, and 67%, respectively. The favorable 12- and 36-month outcomes for frontal lobe epilepsy surgery are 62% and 52%, respectively. For both parietal and occipital epilepsy lobe surgeries the 12- and 36-month outcomes are 67%. For multilobar epilepsy surgery, the 12- and 36-month outcomes are 65% and 50%, respectively. The 12- and 36-month outcomes for functional hemispherectomy epilepsy surgery are 64.2% and 63%, respectively. According to histopathology diagnosis, mesiotemporal sclerosis (MTS) and benign CNS tumors had the best favorable outcome after surgery at 1 year (77.27% and 84.3%, resp.,) and 3 years (76% and 75%, resp.,). The least favorable seizure-free outcome after 3 years occurred in cases with dual pathology (66.6%). Thirty-four epilepsy patients with normal magnetic resonance imaging (MRI) brain scans were surgically treated. The first- and third-year epilepsy surgery outcome of 17 temporal lobe surgeries were (53%) and (47%) seizure-free, respectively. The first- and third-year epilepsy surgery outcomes of 15 extratemporal epilepsy surgeries were (47%) and (33%) seizure-free. Conclusion. The best outcomes are achieved with temporal epilepsy surgery, mesial temporal sclerosis, and benign CNS tumor. The worst outcomes are from multilobar surgery, dual pathology, and normal MRI.

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Dissertations / Theses on the topic "Temporal lobe epilepsy – Research"

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Tian, Nan. "SLEEP-RELATED GENERALIZED TONIC SEIZURE AND HIGH FREQUENCY OSCILLATION (HFOs) IN A MESIAL TEMPORAL LOBE EPILEPSY MOUSE MODEL." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1277440218.

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Walpole, Pete. "An investigation into the implications of emotional intelligence and social cognition research for psychosocial problems associated with temporal lobe epilepsy." Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422171.

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Toprani, Sheela C. "MECHANISMS OF SEIZURE REDUCTION BY LOW FREQUENCY ELECTRICAL STIMULATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1399474125.

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Benini, Ruba Sayed. "GABAergic signalling in temporal lobe epilepsy." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111818.

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Earlier studies on temporal lobe epilepsy (TLE), by focusing on the anatomical and electrophysiological abnormalities of the hippocampus, have attributed a major role to this limbic structure in the process of epileptogenesis and seizure generation. Recently however, there has been increasing evidence from both animal and human studies that other limbic structures, including the subiculum, the entorhinal cortex (EC, perirhinal cortex (PC) as well as the amygdala, are possibly involved in the process of epileptogenesis. With the help of both acute and chronic models of limbic seizures, I have used an electrophysiological approach to gain more insight into the mechanisms through which these structures could participate in the establishment of hyperexcitable neuronal networks. Particularly, my investigations have focused on assessing the role played by the subiculum, the amygdala and the PC in epileptiform synchronization in vitro. My findings demonstrate that seizure-induced cell damage in chronically epileptic mice results in a change in limbic network interactions whereby EC ictogenesis is sustained via a reverberant EC-subiculum pathway ( Chapter 1). Furthermore, I have discovered that the subiculum, which holds an anatomically strategic position within the hippocampus, is capable of gating hippocampul output activity via a GABAA-receptor mediated mechanism (Chapter 2). My investigations in the amygdala have confirmed that this limbic structure contributes to epileptiform synchronization (Chapter 3). Moreover, using a chronic rat model of TLE, I have found novel evidence suggesting that alterations in inhibitory mechanisms play a role in the increased excitability of the lateral amygdalar nucleus (Chapter 4). Finally, my studies in chronically epileptic rats have also led to preliminary data signifying hyperexcitability of the PC as well alterations in the interactions between the amygdala and this cortical structure (Chapter 5).

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Buck, Sarah. "Memory in paediatric temporal lobe epilepsy." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10057610/.

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Temporal lobe epilepsy (TLE) is a common form of epilepsy and is frequently associated with memory and learning impairments. Medically intractable and lesion-based TLE occurs in 20-30% of the patients, in which case a surgical intervention is proposed. However, there is a clear gap in knowledge about pre-operative memory status in children undergoing surgery and post-operative memory outcome. It is unclear whether paediatric patients show material-specific memory impairments associated with side of pathology and whether specific memory processes are affected more than others, i.e. learning, recall and recognition. Lastly, as opposed to language lateralisation, the neural representation of memory is unknown and memory fMRI has never been explored in paediatric TLE. The aim of this project is therefore to investigate the hippocampal-neocortical network that is at risk of compromise given learning and recall deficits in paediatric TLE at the pre-operative level in order to contribute to the prediction of outcome after surgery. I developed a neuropsychological protocol and a neuroimaging protocol for the investigation of pre-operative memory functions. The neuropsychological protocol is a tablet-based version of a paired-associate learning paradigm that allows comparisons between verbal and non-verbal memory. I validated this protocol in normally-developing children (N=130, 8-18 years). The neuroimaging protocol is a combined language and memory fMRI task that allows the investigation of the interaction between the two networks within one scanning session. This protocol was also validated in normally-developing children (N=28, 8-18 years). The feasibility of these protocols for clinical assessments was explored in a representative sample of children with TLE who were being considered for surgery (N=6, 12-18 years). These protocols add value to the diagnosis of memory impairments associated with paediatric TLE and provide a better understanding of pre-operative memory profile at the individual level. The findings also contribute towards the use of memory fMRI in the surgical decision-making process. Combining information from these protocols could provide prognostic indicators of outcome after surgery.

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Morgan, Lisa. "Social cognition in temporal lobe epilepsy." Thesis, University of East London, 2011. http://roar.uel.ac.uk/3675/.

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This study addressed social cognition in patients with temporal lobe epilepsy (TLE). Social cognition encompasses a range of functions, for example, those requiring the attribution of emotional states, and those requiring mental state inferences to be made ('theory of mind'). The area of social cognition has evolved from developmental explanations of theory of mind, which have been extrapolated for their empirical application to adult populations, often using neuroimaging and neuropsychological paradigms. The present study may help to raise awareness of social cognitive difficulties in TLE and may inform clinical neuropsychological assessment protocols. A feature of the existing literature is the lack of consistency in methodologies. This study drew upon methodology described in previous relevant studies in order that findings were more comparable. A range of standardised measures of general intellectual functioning, verbal and visual memory, and verbal and nonverbal executive function tasks were administered alongside social cognition tasks, assessing recognition of emotional expressions, attributing mental states to eyes, attributing mental state inferences in stories and cartoons, and detecting and describing violations of social etiquette. A group of 25 patients with TLE were compared with 42 typically developed and intact (TDI) participants matched for age, education and general abilities. The TLE group scored lower on all social cognition measures, but in the context of similar difficulties in visual and verbal memory, and verbal aspects of executive functioning. There were no significant effects of laterality (hemispheric focus of the TLE). Variables influencing performance on social cognition tasks were examined. The results are discussed in terms of the relevant literature and possible underlying mechanisms of difficulties, and recommendations for future research made on this basis.

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Sidhu, M. K. "Episodic memory in temporal lobe epilepsy." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1471130/.

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Individuals with temporal lobe epilepsy (TLE) have significant material specific episodic memory impairments with greater verbal and visual memory deficits accompanying left and right TLE respectively. More recently, however, widespread cognitive deficits have been described in patients with TLE in keeping with morphological and functional abnormalities that extend beyond the temporal lobes. Functional magnetic resonance imaging (fMRI) has demonstrated reorganisation of memory encoding networks within the temporal lobe in TLE, but little is known of the extra-temporal networks in these patients. Memory fMRI as a tool for predicting memory decline after anterior temporal lobe resection has been explored but a clinically applicable algorithm has yet to be defined. Fewer studies have described the changes in the memory encoding networks after temporal lobe surgery. This thesis presents methodological developments and novel applications to describe the pre-operative and post-operative verbal and visual memory networks in those with unilateral TLE. Pre-operatively, I investigated extra-temporal areas of memory reorganisation in left and right TLE patients, quantitatively compared to healthy controls. Novel findings include the ‘efficiency’ of extra-temporal reorganisation to successful memory formation. Next, using clinical parameters such as age at onset of epilepsy, epilepsy duration and seizure frequency as continuous regressors, I described the factors affecting verbal and visual memory reorganisation in TLE. In a separate pre-operative study, I used an alternative fMRI analysis method, multi-voxel pattern analysis (MVPA) that focuses on the patterns of activity across voxels 4 in specific brain regions that are associated with individual memory traces. I used MVPA-fMRI to assess the functional integrity of the hippocampi and other medial temporal lobe structures in patients with unilateral TLE. Next, I explored the predictive ability of temporal and extra-temporal activations in predicting post-operative verbal memory decline in left and right TLE patients and described a method of using memory fMRI as a clinically applicable tool in patients who had anterior temporal lobe resection. Finally, I explored memory encoding network plasticity four and 12 months after anterior temporal lobe resection. In this study, controls were also scanned at similar time intervals to patients. I report for the first time, dynamic changes in the memory encoding network four and 12 months after surgery, relative to changes in controls. Novel findings also include the efficiency of these post-operative networks. In this thesis, I also discuss methodological constraints, clinical applications and future directions.

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Testa, S. Marc. "DEPRESSIVE SYMPTOMS IN TEMPORAL LOBE EPILEPSY." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin997801556.

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Dinkelacker, Vera. "Network pathology in temporal lobe epilepsy." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066156/document.

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Notre vision de l'épilepsie du lobe temporal avec sclérose hippocampique a beaucoup évolué grâce aux techniques de neuroimagerie multimodale. Initialement perçue comme maladie restreinte à la lésion, à savoir la sclérose hippocampique (SH), elle est aujourd'hui considérée comme un modèle de pathologie en réseau. Cette thèse a pour but d'approfondir les caractéristiques du réseau sous tendant cette épilepsie.Nous avons pour cela recueilli des données de connectivité structurelle, d'EEG et de données cognitives chez une cohorte de 44 patient avec SH unilatérale (22 droite, 22 gauche) et chez 28 sujets contrôle. Nous avons déterminé les régions d'intérêt corticales et le volume hippocampique avec Freesurfer et la connectivité structurelle (locale ou en réseau) avec MRtrix ou FSL.Trois principaux résultats émergent de ces études :1. La connectivité globale montre un pattern de déconnexion très marqué de l'hémisphère gauche en cas de SH gauche. La SH semble donc s'accompagner d'une atteinte de réseau plus importante lorsqu'elle se situe dans l'hémisphère dominant pour le langage.2. La connectivité hippocampo-thalamique est augmentée du côté de la SH. Cette augmentation semble dysfonctionnelle, car corrélée avec une baisse de fonctions cognitives exécutives. 3.L'EEG de ces patients révèle des anomalies interictales ipsi-latérales qui sont corrélées avec une diminution de fonctions cognitives exécutives. Nos données confirment ainsi le concept de l'épilepsie du lobe temporal en tant que pathologie de réseau. L'atteinte structurelle, mais également cognitive s'étend sur des régions à distance de l'hippocampe et affecte notamment les réseaux de langage de l'hémisphère dominant
Our vision of temporal lobe epilepsy (TLE) with hippocampal sclerosis has much evolved in recent years. Initially regarded as a disease centered on a single lesion, it is now perceived as a genuine network disease, which we intended to explore with a multimodal approach. We examined structural connectivity, fMRI, EEG and cognitive dysfunction in a cohort of 44 patients with unilateral hippocampal sclerosis (HS, 22 with right, 22 with left HS) and 28 healthy age and gender matched control participants. Cortical regions of interest and hippocampal volumes were determined with Freesurfer, structural connectivity with MRtrix (pairwise disconnections and component effects with Network Based Statistics), or for hippocampal-thalamic connections with FSL. We found a pronounced pattern of disconnections most notably in the left hemisphere of patients with left TLE. Network Based Statistics showed large bi hemispheric clusters lateralized to the diseased side in both left and right temporal lobe epilepsy. We suggest that hippocampal sclerosis is associated with widespread disconnections if situated in the dominant hemisphere. We then determined streamline connections between hippocampus and thalamus and found an increase in connections in relation to the HS. This increase was seemingly dysfunctional as the number of hippocampal-thalamic connections was negatively correlated with performance in executive tasks. EEG analysis revealed predominantly ipsilateral epileptic discharge. The number of sharp waves was highly correlated with a number of executive functions depending on the frontal lobe, hence at distance of the HS. Our data thus confirms the concept of temporal lobe epilepsy as a network disease that finds its expression both in widespread, though lateralized alterations of structural connectivity and in neuropsychological dysfunction way beyond the hippocampus

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10

Arcot, Desai Sharanya. "Multielectrode microstimulation for temporal lobe epilepsy." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/50384.

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Multielectrode arrays may have several advantages compared to the traditional single macroelectrode brain electrical stimulation technique including less tissue damage due to implantation and the ability to deliver several spatio-temporal patterns of stimulation. Prior work on cell cultures has shown that multielectrode arrays are capable of completely stopping seizure-like spontaneous bursting events through a distributed asynchronous multi-site approach. In my studies, I used a similar approach for controlling seizures in a rat model of temporal lobe epilepsy. First, I developed a new method of electroplating in vivo microelectrode arrays for durably improving their impedance. I showed that microelectrode arrays electroplated through the new technique called sonicoplating, required the least amount of voltage in current controlled stimulation studies and also produced the least amplitude and duration of stimulation artifact compared to unplated, DC electroplated or pulse-plated microelectrodes. Second, using c-fos immunohistochemistry, I showed that 16-electrode sonicoplated microelectrode arrays can activate 5.9 times more neurons in the dorsal hippocampus compared to a single macroelectrodes while causing < 77% the tissue damage. Next, through open-loop multisite asynchronous microstimulation, I reduced seizure frequency by ~50% in the rodent model of temporal lobe epilepsy. Preliminary studies aimed at using the same stimulation protocol in closed-loop responsive and predictive seizure control did not stop seizures. Finally, through an internship at Medtronic Neuromodulation, I worked on developing and implementing a rapid algorithm prototyping research tool for closed-loop human deep brain stimulation applications.

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Books on the topic "Temporal lobe epilepsy – Research"

1

The neuropathology of temporal lobe epilepsy. Oxford: Oxford University Press, 1988.

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2

Janet, Lindsay, and Richards Peronelle, eds. Temporal lobe epilepsy, 1948-1986: A biographical study. London: Mac Keith, 1987.

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3

LaPlante, Eve. Seized. New York: HarperCollins, 1993.

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4

A, Arzimanoglou, ed. Cognitive dysfunction in children with temporaral lobe epilepsy. Montrouge, France: John Libbey Eurotext, 2005.

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5

Chopin in the attic. Sharon, MA: Silverberry Press, 2011.

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6

Philips, Matthew Frank. Synaptic and pathway remodeling of the human Hippocampus in temporal lobe epilepsy. [New Haven, Conn: s.n.], 1993.

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7

Dare, Amos O. Ouabain potentiates kainate neurotoxicity: A new rat model of human temporal lobe epilepsy. [New Haven, Conn: s.n.], 1996.

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8

Schofield-king, Jacqueline L. An investigation into the emotional and behavioural difficulties of children with Temporal Lobe Epilepsy. Birmingham: University of Birmingham, 1998.

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9

Billinton, Andrew. Brain GABA[Beta] receptors and GBR1 mRNA in rat seizure models and human temporal lobe epilepsy. Birmingham: University of Birmingham, 1999.

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10

Baird, Virginia Helen. NMDA receptors in hippocampal sclerosis associated with intractable human temporal lobe epilepsy: An investigation of receptor, mRNA and neurone densities. Birmingham: University of Birmingham, 1998.

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Book chapters on the topic "Temporal lobe epilepsy – Research"

1

Damasceno, Benito. "Temporal Lobe Epilepsy." In Research on Cognition Disorders, 207–14. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-57267-9_19.

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Qiu, Zhi-Jun, Hong-Yan Zhang, and Xin Tian. "Research of EEG from Patients with Temporal Lobe Epilepsy on Causal Analysis of Directional Transfer Functions." In Neural Information Processing, 337–44. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-24955-6_41.

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Huk, W. J. "Temporal Lobe Epilepsy." In Magnetic Resonance Imaging of Central Nervous System Diseases, 225–28. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-72568-5_9.

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Barr, William B., and Stella Karantzoulis. "Temporal Lobe Epilepsy." In Encyclopedia of Clinical Neuropsychology, 2482–83. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-0-387-79948-3_1058.

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Barr, William B., and Stella Karantzoulis. "Temporal Lobe Epilepsy." In Encyclopedia of Clinical Neuropsychology, 1–2. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56782-2_1058-2.

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Barr, William B., and Stella Karantzoulis. "Temporal Lobe Epilepsy." In Encyclopedia of Clinical Neuropsychology, 3419–21. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-57111-9_1058.

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Brunette-Clement, Tristan, Aria Fallah, and Alexander G. Weil. "Temporal Lobe Epilepsy." In Pediatric Neurosurgery for Clinicians, 553–92. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-80522-7_38.

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Stern, John M., and Noriko Salamon. "Temporal Lobe Trauma." In Imaging of Epilepsy, 121–23. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-86672-3_29.

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Tatum, William O. "Medial Temporal Lobe Epilepsy." In Adult Epilepsy, 221–45. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9780470975039.ch14.

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Girvin, John P. "Temporal Lobe Surgery." In Operative Techniques in Epilepsy, 125–63. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-10921-3_6.

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Conference papers on the topic "Temporal lobe epilepsy – Research"

1

Hao, Jiaxin, Yuhai Xie, Qiangqiang Liu, Jiwen Xu, and Puming Zhang. "Localization of Epileptogenic Zone Based on Radiomics Features of 18F-FDG PET in Patients with Temporal Lobe Epilepsy**Research supported by the National Natural Science Foundation of China (No. 82071550)." In 2021 10th International IEEE/EMBS Conference on Neural Engineering (NER). IEEE, 2021. http://dx.doi.org/10.1109/ner49283.2021.9441427.

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2

Ghazi, Nayereh, and Hamid Soltanian-Zadeh. "Structural connectivity of temporal lobe structures detects temporal lobe epilepsy." In 2016 23rd Iranian Conference on Biomedical Engineering and 2016 1st International Iranian Conference on Biomedical Engineering (ICBME). IEEE, 2016. http://dx.doi.org/10.1109/icbme.2016.7890924.

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3

Diniz, P. B., C. E. Salmon, T. R. Velasco, A. C. Sakamoto, J. P. Leite, and A. C. Santos. "White matter alterations in temporal lobe epilepsy." In SPIE Medical Imaging, edited by John B. Weaver and Robert C. Molthen. SPIE, 2011. http://dx.doi.org/10.1117/12.877190.

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4

Lv, Bin, Huiguang He, Jingjing Lu, Wenjing Li, Dai Dai, Meng Li, and Zhengyu Jin. "Altered cortical anatomical networks in temporal lobe epilepsy." In SPIE Medical Imaging, edited by John B. Weaver and Robert C. Molthen. SPIE, 2011. http://dx.doi.org/10.1117/12.877808.

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Siadat, Mohammad-Reza, Hamid Soltanian-Zadeh, Farshad A. Fotouhi, and Kost Elisevich. "Multimodality medical image database for temporal lobe epilepsy." In Medical Imaging 2003, edited by H. K. Huang and Osman M. Ratib. SPIE, 2003. http://dx.doi.org/10.1117/12.481936.

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P., Nishanth, and Rupam Borgohain. "Social Cognition Abilities in Patients with Chronic Temporal Lobe Epilepsy." In 20th Joint Annual Conference of Indian Epilepsy Society and Indian Epilepsy Association. Thieme Medical and Scientific Publishers Private Ltd., 2018. http://dx.doi.org/10.1055/s-0039-1694887.

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Zaveri, H. P., L. D. Iasemidis, W. J. Williams, and J. C. Sackellares. "Multielectrode analysis of the electrocorticogram in temporal lobe epilepsy." In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1988. http://dx.doi.org/10.1109/iembs.1988.94873.

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Iasemidis, L. D., H. P. Zaveri, J. C. Sackellares, and W. J. Williams. "Phase space analysis of EEG in temporal lobe epilepsy." In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1988. http://dx.doi.org/10.1109/iembs.1988.94874.

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Samotaeva, Irina, Nikolay Ierusalimsky, Sabir Burkitbayev, and Flora Rider. "PATTERNS OF BRAIN FUCTIONAL CONNECTIVITY IN TEMPORAL LOBE EPILEPSY." In XVII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2021. http://dx.doi.org/10.29003/m2310.sudak.ns2021-17/333-334.

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Jafari-Khouzani, Kourosh, Hamid Soltanian-Zadeh, and Kost Elisevich. "Hippocampus Volume and Texture Analysis for Temporal Lobe Epilepsy." In 2006 IEEE International Conference on Electro/Information Technology. IEEE, 2006. http://dx.doi.org/10.1109/eit.2006.252120.

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Reports on the topic "Temporal lobe epilepsy – Research"

1

Ye, Qing, Quan Wen, Yi-ming Sun, Xin-ru Liu, Yu-xuan Peng, Xueping Yang, and Yu Dai. Resting-state fMRI in temporal lobe epilepsy patients with cognitive impairment: protocol for a meta-analysis and systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2021. http://dx.doi.org/10.37766/inplasy2021.3.0092.

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