Relevant bibliographies by topics / Temporal lobe epilepsy

Academic literature on the topic 'Temporal lobe epilepsy'

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Published: 4 June 2021
Last updated: 30 July 2024

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Journal articles on the topic "Temporal lobe epilepsy"

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Ribbeck Lourdes, Simbrón, Sandoval Paredes Josefina, Amador Sánchez Karen, and Taboada Barajas Jesús. "Uncinate Fasciculus in Temporal Lobe Epilepsy." Brain and Neurological Disorders 2, no. 2 (October 7, 2019): 01–04. http://dx.doi.org/10.31579/2642-973x/010.

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Background and purpose: Temporal lobe epilepsy is the most common focal intractable epilepsy. Uncinate fasciculus is a white fiber bundle that connects the orbitofrontal cortex with the anterior temporal lobe, and is implicated in most of the superior mental functions. There is evidence of uncinate fasciculus as a propagation pathway of seizures from temporal lobe. The aim of the study is to determine uncinate fasciculus alterations in patients with temporal lobe epilepsy, through fractional anisotropy. Methods: Thirty-three patients with temporal lobe epilepsy (10 right and 23 left) were studied. All of them were right-handed and had left hemisphere dominance for language. A 1.5 T MR imaging scanner was used to obtain diffusion tensor imaging (DTI). Fractional anisotropy of uncinate fasciculus was calculated through TBSS (Tract Based Spatial Statistics). Statistical analysis was done using IBM SPSS (v. 25). Results: Fractional anisotropy was higher in right uncinate fasciculus, regardless of epilepsy side. Right uncinate fasciculus, at the insula level, showed lower fractional anisotropy in patients with right temporal lobe epilepsy. Conclusions: Results support the evidence of uncinate fasciculus as a pathway of propagation in temporal lobe epilepsy, specially at insular level.
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Engel, Jerome. "When is temporal lobe epilepsy not temporal lobe epilepsy?" Brain 139, no. 2 (January 29, 2016): 309–12. http://dx.doi.org/10.1093/brain/awv374.

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Grassia, Fabio, Andrew V. Poliakov, Sandra L. Poliachik, Kaitlyn Casimo, Seth D. Friedman, Hillary Shurtleff, Carlo Giussani, Edward J. Novotny, Jeffrey G. Ojemann, and Jason S. Hauptman. "Changes in resting-state connectivity in pediatric temporal lobe epilepsy." Journal of Neurosurgery: Pediatrics 22, no. 3 (September 2018): 270–75. http://dx.doi.org/10.3171/2018.3.peds17701.

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OBJECTIVEFunctional connectivity magnetic resonance imaging (fcMRI) is a form of fMRI that allows for analysis of blood oxygen level–dependent signal changes within a task-free, resting paradigm. This technique has been shown to have efficacy in evaluating network connectivity changes with epilepsy. Presurgical data from patients with unilateral temporal lobe epilepsy were evaluated using the fcMRI technique to define connectivity changes within and between the diseased and healthy temporal lobes using a within-subjects design.METHODSUsing presurgical fcMRI data from pediatric patients with unilateral temporal lobe epilepsy, the authors performed seed-based analyses within the diseased and healthy temporal lobes. Connectivity within and between temporal lobe seeds was measured and compared.RESULTSIn the cohort studied, local ipsilateral temporal lobe connectivity was significantly increased on the diseased side compared to the healthy temporal lobe. Connectivity of the diseased side to the healthy side, on the other hand, was significantly reduced when compared to connectivity of the healthy side to the diseased temporal lobe. A statistically significant regression was observed when comparing the changes in local ipsilateral temporal lobe connectivity to the changes in inter–temporal lobe connectivity. A statistically significant difference was also noted in ipsilateral connectivity changes between patients with and those without mesial temporal sclerosis.CONCLUSIONSUsing fcMRI, significant changes in ipsilateral temporal lobe and inter–temporal lobe connectivity can be appreciated in unilateral temporal lobe epilepsy. Furthermore, fcMRI may have a role in the presurgical evaluation of patients with intractable temporal lobe epilepsy.
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Sundram, Frederick, Mary Cannon, Colin P. Doherty, Gareth J. Barker, Mary Fitzsimons, Norman Delanty, and David Cotter. "Neuroanatomical correlates of psychosis in temporal lobe epilepsy: voxel-based morphometry study." British Journal of Psychiatry 197, no. 6 (December 2010): 482–92. http://dx.doi.org/10.1192/bjp.bp.110.080218.

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BackgroundTemporal lobe epilepsy is associated with a significant risk of psychosis but there are only limited studies investigating the underlying neurobiology.AimsTo characterise neuroanatomical changes in temporal lobe epilepsy and comorbid psychosis.MethodThe study population comprised all individuals with temporal lobe epilepsy on the epilepsy database at the National Centre for Epilepsy and Epilepsy Neurosurgery in Ireland (Beaumont Hospital) between 2002 and 2006. Ten people with temporal lobe epilepsy with psychosis were matched for age, gender, handedness, epilepsy duration, seizure laterality, severity of epilepsy and anti-epileptic medication with ten comparison participants with temporal lobe epilepsy only. Participants received a magnetic resonance imaging scan and voxel-based morphometry analyses were applied to grey and white matter anatomy.ResultsSignificant grey matter reduction was found bilaterally in those with temporal lobe epilepsy with psychosis in the temporal lobes in the inferior, middle and superior temporal gyri and fusiform gyri, and unilaterally in the left parahippocampal gyrus and hippocampus. Significant extra-temporal grey matter reduction was found bilaterally in the insula, cerebellum, caudate nuclei and in the right cingulum and left inferior parietal lobule. Significant white matter reduction in those with temporal lobe epilepsy with psychosis was found bilaterally in the hippocampus, parahippocampal/fusiform gyri, middle/inferior temporal gyri, cingulum, corpus callosum, posterior thalamic radiation, anterior limb of internal capsule and white matter fibres from the caudate nuclei, and unilaterally in the left lingual gyrus and right midbrain and superior temporal gyrus.ConclusionsSignificant grey and white matter deficits occur in temporal lobe epilepsy with psychosis. These encompass the medial temporal lobe structures but also extend to lateral temporal and extra-temporal regions. Some of these deficits overlap with those found in schizophrenia.
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Franzon, Renata C., and Marilisa M. Guerreiro. "Temporal lobe epilepsy in childhood: review article." Journal of Epilepsy and Clinical Neurophysiology 12, no. 1 suppl 1 (March 2006): 26–31. http://dx.doi.org/10.1590/s1676-26492006000200006.

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INTRODUCTION: The authors present a review article on temporal lobe epilepsy in childhood. METHODS: We performed a search in the literature. RESULTS: The main etiologies of temporal lobe epilepsy in childhood are developmental tumors and focal cortical displasia, besides temporal medial sclerosis. The clinical features may be variable particularly in children younger than six years of age. Epilepsy may present with generalized seizures. Electroencephalographic findings are also variable and show a functional dysfunction of several brain areas besides temporal lobes, especially frontal lobes. CONCLUSION: Recent advances demonstrate that temporal lobe epilepsy in childhood present with great etiologic, clinical and electroencephalographic diversity.
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Valente, Kette D. R., and Geraldo Busatto Filho. "Depression and temporal lobe epilepsy represent an epiphenomenon sharing similar neural networks: clinical and brain structural evidences." Arquivos de Neuro-Psiquiatria 71, no. 3 (March 2013): 183–90. http://dx.doi.org/10.1590/s0004-282x2013000300011.

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The relationship between depression and epilepsy has been known since ancient times, however, to date, it is not fully understood. The prevalence of psychiatric disorders in persons with epilepsy is high compared to general population. It is assumed that the rate of depression ranges from 20 to 55% in patients with refractory epilepsy, especially considering those with temporal lobe epilepsy caused by mesial temporal sclerosis. Temporal lobe epilepsy is a good biological model to understand the common structural basis between depression and epilepsy. Interestingly, mesial temporal lobe epilepsy and depression share a similar neurocircuitry involving: temporal lobes with hippocampus, amygdala and entorhinal and neocortical cortex; the frontal lobes with cingulate gyrus; subcortical structures, such as basal ganglia and thalamus; and the connecting pathways. We provide clinical and brain structural evidences that depression and epilepsy represent an epiphenomenon sharing similar neural networks.
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Carne, Ross P., Terence J. O'Brien, Christine J. Kilpatrick, Lachlan R. MacGregor, Rodney J. Hicks, Michael A. Murphy, Stephen C. Bowden, Andrew H. Kaye, and Mark J. Cook. "Temporal Lobe Epilepsy." Journal of Neurosurgery 103, no. 4 (October 2005): 768–69. http://dx.doi.org/10.3171/jns.2005.103.4.0768.

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Abstract Object. The syndrome of medial temporal lobe epilepsy (MTLE) may occur in patients in whom magnetic resonance (MR) images demonstrate normal findings. In these patients, there is no evidence of hippocampal sclerosis on neuroimaging, and histopathological examination of the resected hippocampus does not reveal significant neuron loss. In this paper the authors describe the distinct clinical features of this MTLE subtype, referred to as paradoxical temporal lobe epilepsy (PTLE). Methods. The authors selected 12 consecutive patients with preoperative findings consistent with MTLE in whom MR imaging did not demonstrate any hippocampal abnormality. Onset of hippocampal seizure was confirmed by long-term intracranial monitoring. There were six female and six male patients with a mean age of 32 ± 11 years (mean ± standard deviation [SD]) at presentation. These patients' seizure histories, available hippocampal volumetric measurements, and hippocampal cell densities in different subfields were reviewed. Sharp electrode recordings from dentate granule cells that had been maintained in hippocampal slices provided a measure of excitation and inhibition in the tissue. We compared these data with those of a cohort of 50 randomly selected patients who underwent anteromedial temporal resection for medial temporal sclerosis (MTS) during the same time period (1987–1999). The durations of follow up (means ± SDs) for the PTLE and MTS groups were 51 ± 59 months and 88 ± 44 months, respectively. A history of febrile seizure was present less frequently in the PTLE group (8%) than in the MTS group (34%). Other risk factors for epilepsy such as trauma, meningoencephalitis, or perinatal injuries were present more frequently in the PTLE group (50%) than in the MTS cohort (36%). In patients in the PTLE group the first seizure occurred later in life (mean age at seizure onset 14 years in the PTLE group compared with 9 years in the MTS group, p = 0.09). Ten patients (83%) in the PTLE cohort and 23 patients (46%) in the MTLE cohort had secondary generalization of their seizures. Among patients with PTLE, volumetric measurements (five patients) and randomized blinded visual inspection (seven patients) of the bilateral hippocampi revealed no atrophy and no increased T2 signal change on preoperative MR images. All patients with PTLE underwent anteromedial temporal resection (amygdalohippocampectomy, in five patients on the left side and in seven on the right side). Electrophysiological studies of hippocampal slices demonstrated that dentate granule cells from patients with PTLE were significantly less excitable than those from patients with MTS. The mean pyramidal cell loss in the CA1 subfield in patients in the PTLE group was 20% (range 0–59%) and that in patients in the MTS group was 75% (range 41–90%) (p < 0.001). Maximal neuron loss (mean loss 38%) occurred in the CA4 region in six patients with PTLE (end folium sclerosis). At the last follow-up examination, six patients (50%) in the PTLE group were seizure free compared with 38 patients (76%) in the MTS group. Conclusions. Clinical PTLE is a distinct syndrome with clinical features and surgical outcomes different from those of MTS.
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Beit-Jones, Meredith S., and Lissa Robins Kapust. "Temporal Lobe Epilepsy." Social Work in Health Care 11, no. 2 (March 10, 1986): 17–33. http://dx.doi.org/10.1300/j010v11n02_02.

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Bernhardt, Boris C., Fatemeh Fadaie, Min Liu, Benoit Caldairou, Shi Gu, Elizabeth Jefferies, Jonathan Smallwood, Danielle S. Bassett, Andrea Bernasconi, and Neda Bernasconi. "Temporal lobe epilepsy." Neurology 92, no. 19 (April 19, 2019): e2209-e2220. http://dx.doi.org/10.1212/wnl.0000000000007447.

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ObjectiveTo assess whether hippocampal sclerosis (HS) severity is mirrored at the level of large-scale networks.MethodsWe studied preoperative high-resolution anatomical and diffusion-weighted MRI of 44 temporal lobe epilepsy (TLE) patients with histopathologic diagnosis of HS (n = 25; TLE-HS) and isolated gliosis (n = 19; TLE-G) and 25 healthy controls. Hippocampal measurements included surface-based subfield mapping of atrophy and T2 hyperintensity indexing cell loss and gliosis, respectively. Whole-brain connectomes were generated via diffusion tractography and examined using graph theory along with a novel network control theory paradigm that simulates functional dynamics from structural network data.ResultsCompared to controls, we observed markedly increased path length and decreased clustering in TLE-HS compared to controls, indicating lower global and local network efficiency, while TLE-G showed only subtle alterations. Similarly, network controllability was lower in TLE-HS only, suggesting limited range of functional dynamics. Hippocampal imaging markers were positively associated with macroscale network alterations, particularly in ipsilateral CA1-3. Systematic assessment across several networks revealed maximal changes in the hippocampal circuity. Findings were consistent when correcting for cortical thickness, suggesting independence from gray matter atrophy.ConclusionsSevere HS is associated with marked remodeling of connectome topology and structurally governed functional dynamics in TLE, as opposed to isolated gliosis, which has negligible effects. Cell loss, particularly in CA1-3, may exert a cascading effect on brain-wide connectomes, underlining coupled disease processes across multiple scales.
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Garyfallos, George, Nikolas Manos, and Aravela Adamopoulou. "Temporal Lobe Epilepsy." British Journal of Psychiatry 153, no. 6 (December 1988): 852–53. http://dx.doi.org/10.1192/bjp.153.6.852.

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Dissertations / Theses on the topic "Temporal lobe epilepsy"

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Dinkelacker, Vera. "Network pathology in temporal lobe epilepsy." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066156/document.

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Notre vision de l'épilepsie du lobe temporal avec sclérose hippocampique a beaucoup évolué grâce aux techniques de neuroimagerie multimodale. Initialement perçue comme maladie restreinte à la lésion, à savoir la sclérose hippocampique (SH), elle est aujourd'hui considérée comme un modèle de pathologie en réseau. Cette thèse a pour but d'approfondir les caractéristiques du réseau sous tendant cette épilepsie.Nous avons pour cela recueilli des données de connectivité structurelle, d'EEG et de données cognitives chez une cohorte de 44 patient avec SH unilatérale (22 droite, 22 gauche) et chez 28 sujets contrôle. Nous avons déterminé les régions d'intérêt corticales et le volume hippocampique avec Freesurfer et la connectivité structurelle (locale ou en réseau) avec MRtrix ou FSL.Trois principaux résultats émergent de ces études :1. La connectivité globale montre un pattern de déconnexion très marqué de l'hémisphère gauche en cas de SH gauche. La SH semble donc s'accompagner d'une atteinte de réseau plus importante lorsqu'elle se situe dans l'hémisphère dominant pour le langage.2. La connectivité hippocampo-thalamique est augmentée du côté de la SH. Cette augmentation semble dysfonctionnelle, car corrélée avec une baisse de fonctions cognitives exécutives. 3.L'EEG de ces patients révèle des anomalies interictales ipsi-latérales qui sont corrélées avec une diminution de fonctions cognitives exécutives. Nos données confirment ainsi le concept de l'épilepsie du lobe temporal en tant que pathologie de réseau. L'atteinte structurelle, mais également cognitive s'étend sur des régions à distance de l'hippocampe et affecte notamment les réseaux de langage de l'hémisphère dominant
Our vision of temporal lobe epilepsy (TLE) with hippocampal sclerosis has much evolved in recent years. Initially regarded as a disease centered on a single lesion, it is now perceived as a genuine network disease, which we intended to explore with a multimodal approach. We examined structural connectivity, fMRI, EEG and cognitive dysfunction in a cohort of 44 patients with unilateral hippocampal sclerosis (HS, 22 with right, 22 with left HS) and 28 healthy age and gender matched control participants. Cortical regions of interest and hippocampal volumes were determined with Freesurfer, structural connectivity with MRtrix (pairwise disconnections and component effects with Network Based Statistics), or for hippocampal-thalamic connections with FSL. We found a pronounced pattern of disconnections most notably in the left hemisphere of patients with left TLE. Network Based Statistics showed large bi hemispheric clusters lateralized to the diseased side in both left and right temporal lobe epilepsy. We suggest that hippocampal sclerosis is associated with widespread disconnections if situated in the dominant hemisphere. We then determined streamline connections between hippocampus and thalamus and found an increase in connections in relation to the HS. This increase was seemingly dysfunctional as the number of hippocampal-thalamic connections was negatively correlated with performance in executive tasks. EEG analysis revealed predominantly ipsilateral epileptic discharge. The number of sharp waves was highly correlated with a number of executive functions depending on the frontal lobe, hence at distance of the HS. Our data thus confirms the concept of temporal lobe epilepsy as a network disease that finds its expression both in widespread, though lateralized alterations of structural connectivity and in neuropsychological dysfunction way beyond the hippocampus
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Amorim, Barbara Juarez. "Analise estatistica baseada em voxel do SPECT cerebral em pacientes com epilepsia de lobo temporal." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313716.

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Orientadores: Fernando Cendes, Elba Cristina Sa de Camargo Etchebehere
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-08T16:14:13Z (GMT). No. of bitstreams: 1 Amorim_BarbaraJuarez_D.pdf: 19998647 bytes, checksum: 077344d8015d725dd9cde43d2987f38d (MD5) Previous issue date: 2007
Resumo: O statistical parametric mapping (SPM) é uma ferramenta de quantificação que tem sido usada no SPECT de perfusão cerebral (SPECT), mas apenas poucos trabalhos na literatura comparam a sua sensibilidade com a da análise visual em pacientes com epilepsia de lobo temporal (ELT) OBJETIVO: Avaliar a capacidade da análise com SPM no SPECT em detectar o foco epileptogênico e alterações perfusionais em regiões extra-temporais em pacientes com epilepsia de lobo temporal mesial (ELTM), comparando os seus achados com os da análise visual MÉTODOS: Foram realizados SPECTs ictal e interictal em 22 pacientes com ELTM refratários ao tratamento clínico. O lado do foco epileptogênico foi definido com base na história clínica, ressonância magnética, eletroencefaiogramas seriados e telemetria. Os SPECTs foram submetidos à análise visual sendo que os SPECTs interictal e ictal foram analisados em conjunto pelos observadores (SPECT-visual-inter e SPECT-visual-ictal). Foi aplicado o SPM2 que comparou os pacientes com um grupo controle de 50 indivíduos normais. No SPM foram realizadas as seguintes comparações: grupo de SPECT interictal com o grupo controle (SPM-grupo-inter); SPECT interictal de cada paciente com o grupo controle (SPM-indiv-inter); grupo de SPECT ictal com o grupo controle (SPM-grupo-ictal); SPECT ictal de cada paciente com o grupo controle (SPM-indiv-ictal). Foram também comparadas as intensidades das alterações perfusionais nos lobos temporais procurando-se por um aumento da perfusão no SPECT ictal em relação ao interictal (SPM-indiv-ictal/inter). RESULTADOS: Não foi observada nenhuma alteração perfusional significativa no SPM-grupo-inter Já no SPM-grupo-ictal o foco epileptogênico foi a região de hiperperfusão mais significativa No SPM-indiv-inter a sensibilidade na localização do foco foi de 45% e no SPM-indiv-ictal a sensibilidade foi de 64%. O SPM-indiv-ictal/inter apresentou a maior sensibilidade para detectar o foco dentre as análises realizadas no SPM (77%) A sensibilidade do SPECT-visual-inter foi de 68% e para o SPECT-visuai-ictal foi de 100%. Por outro lado, diversas áreas de hiperperfusão e hipoperfusão à distância no SPECT ictal foram detectadas principalmente com o SPM CONCLUSÃO: O SPM é uma ferramenta que não depende do operador e é capaz de demonstrar mais áreas de alteração perfusional à distância do foco epileptogênico do que a análise visual. Ele pode ajudar a entender melhor a patofisiologia das crises epilépticas em pacientes com ELTM estudando a relação das diferentes regiões corticais e subcorticais na gênese e na propagação das crises parciais. Entretanto, essa ferramenta não acrescentou um aumento na sensibilidade na localização do foco epileptogênico em relação á análise visual, tanto do SPECT interictal quanto do SPECT ictal
Abstract: Statistical parametric mapping (SPM) is a quantitative tool which has been used in the brain perfusion SPECT (SPECT) However, few works in literature compare its sensitivity with the visual analysis in patients with temporal lobe epilepsy (TLE). PURPOSE: To investigate the capability of SPM analysis in SPECT to detect the epileptogenic focus and distant perfusion abnormalities in patients with mesial temporal lobe epilepsy (MTLE) and to compare these findings to the visual analysis. METHODS: Interictal and ictal SPECTs of 22 patients with refractory MTLE were performed. Epileptic foci were determined based on clinical history, magnetic resonance, electroencephalograms (EEG) and ictal video-EEG. SPECTs were submitted to visual analysis. Ictal and interictal SPECTs were analyzed together by the nuclear physicians (SPECT-visual-inter and SPECT-visual-ictal). It was also performed the SPM2 analysis which used a control group composed of 50 volunteers. The following comparisons were performed in SPM: interictal SPECT group with control group (SPM-group-inter); interictal SPECT from each patient with control group (SPM-indiv-inter); ictal SPECT group with control group (SPM-group-ictal), ictal SPECT from each patient with control group (SPM-indiv-ictal). It was also compared the perfusion intensity in temporal lobes looking for an increase in perfusion on ictal SPECT in relation to interictal SPECT (SPM-indiv-ictal/inter). RESULTS: No significant perfusion alterations were observed on SPM-group-inter. On the other hand, the epileptogenic temporal lobe was the region with most significant hypoperfusion on SPM-group-ictal. The sensitivity to localize the focus on SPM-indiv-inter was 45% and on SPM-indiv-ictal was 64%. The SPM-indiv ictal/inter revealed the highest sensitivity among the SPM analysis to detect the focus (77%). The sensitivity of SPECT-visual-inter was 68% and to SPECT-visual-ictal was 100%. On the other hand, several areas of distant hypoperfusion and hypoperfusion were detected mainly with SPM. CONCLUSION: SPM is a tool which does not depend on the operator and can detect more distant perfusion abnormalities than the visual analysis. It can improve the understanding of pathophysiology in seizures of patients with MTLE by studying the relation among different cortical and subcortical areas in the genesis and propagation of partial seizures. However, this tool did not increase the visual analysis sensitivity to localize the epileptogenic focus in interictal SPECT as well as in ictal SPECT
Doutorado
Neurologia
Doutor em Ciências Médicas
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Benini, Ruba Sayed. "GABAergic signalling in temporal lobe epilepsy." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111818.

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Earlier studies on temporal lobe epilepsy (TLE), by focusing on the anatomical and electrophysiological abnormalities of the hippocampus, have attributed a major role to this limbic structure in the process of epileptogenesis and seizure generation. Recently however, there has been increasing evidence from both animal and human studies that other limbic structures, including the subiculum, the entorhinal cortex (EC, perirhinal cortex (PC) as well as the amygdala, are possibly involved in the process of epileptogenesis. With the help of both acute and chronic models of limbic seizures, I have used an electrophysiological approach to gain more insight into the mechanisms through which these structures could participate in the establishment of hyperexcitable neuronal networks. Particularly, my investigations have focused on assessing the role played by the subiculum, the amygdala and the PC in epileptiform synchronization in vitro. My findings demonstrate that seizure-induced cell damage in chronically epileptic mice results in a change in limbic network interactions whereby EC ictogenesis is sustained via a reverberant EC-subiculum pathway ( Chapter 1). Furthermore, I have discovered that the subiculum, which holds an anatomically strategic position within the hippocampus, is capable of gating hippocampul output activity via a GABAA-receptor mediated mechanism (Chapter 2). My investigations in the amygdala have confirmed that this limbic structure contributes to epileptiform synchronization (Chapter 3). Moreover, using a chronic rat model of TLE, I have found novel evidence suggesting that alterations in inhibitory mechanisms play a role in the increased excitability of the lateral amygdalar nucleus (Chapter 4). Finally, my studies in chronically epileptic rats have also led to preliminary data signifying hyperexcitability of the PC as well alterations in the interactions between the amygdala and this cortical structure (Chapter 5).
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Buck, Sarah. "Memory in paediatric temporal lobe epilepsy." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10057610/.

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Temporal lobe epilepsy (TLE) is a common form of epilepsy and is frequently associated with memory and learning impairments. Medically intractable and lesion-based TLE occurs in 20-30% of the patients, in which case a surgical intervention is proposed. However, there is a clear gap in knowledge about pre-operative memory status in children undergoing surgery and post-operative memory outcome. It is unclear whether paediatric patients show material-specific memory impairments associated with side of pathology and whether specific memory processes are affected more than others, i.e. learning, recall and recognition. Lastly, as opposed to language lateralisation, the neural representation of memory is unknown and memory fMRI has never been explored in paediatric TLE. The aim of this project is therefore to investigate the hippocampal-neocortical network that is at risk of compromise given learning and recall deficits in paediatric TLE at the pre-operative level in order to contribute to the prediction of outcome after surgery. I developed a neuropsychological protocol and a neuroimaging protocol for the investigation of pre-operative memory functions. The neuropsychological protocol is a tablet-based version of a paired-associate learning paradigm that allows comparisons between verbal and non-verbal memory. I validated this protocol in normally-developing children (N=130, 8-18 years). The neuroimaging protocol is a combined language and memory fMRI task that allows the investigation of the interaction between the two networks within one scanning session. This protocol was also validated in normally-developing children (N=28, 8-18 years). The feasibility of these protocols for clinical assessments was explored in a representative sample of children with TLE who were being considered for surgery (N=6, 12-18 years). These protocols add value to the diagnosis of memory impairments associated with paediatric TLE and provide a better understanding of pre-operative memory profile at the individual level. The findings also contribute towards the use of memory fMRI in the surgical decision-making process. Combining information from these protocols could provide prognostic indicators of outcome after surgery.
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Morgan, Lisa. "Social cognition in temporal lobe epilepsy." Thesis, University of East London, 2011. http://roar.uel.ac.uk/3675/.

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This study addressed social cognition in patients with temporal lobe epilepsy (TLE). Social cognition encompasses a range of functions, for example, those requiring the attribution of emotional states, and those requiring mental state inferences to be made ('theory of mind'). The area of social cognition has evolved from developmental explanations of theory of mind, which have been extrapolated for their empirical application to adult populations, often using neuroimaging and neuropsychological paradigms. The present study may help to raise awareness of social cognitive difficulties in TLE and may inform clinical neuropsychological assessment protocols. A feature of the existing literature is the lack of consistency in methodologies. This study drew upon methodology described in previous relevant studies in order that findings were more comparable. A range of standardised measures of general intellectual functioning, verbal and visual memory, and verbal and nonverbal executive function tasks were administered alongside social cognition tasks, assessing recognition of emotional expressions, attributing mental states to eyes, attributing mental state inferences in stories and cartoons, and detecting and describing violations of social etiquette. A group of 25 patients with TLE were compared with 42 typically developed and intact (TDI) participants matched for age, education and general abilities. The TLE group scored lower on all social cognition measures, but in the context of similar difficulties in visual and verbal memory, and verbal aspects of executive functioning. There were no significant effects of laterality (hemispheric focus of the TLE). Variables influencing performance on social cognition tasks were examined. The results are discussed in terms of the relevant literature and possible underlying mechanisms of difficulties, and recommendations for future research made on this basis.
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Sidhu, M. K. "Episodic memory in temporal lobe epilepsy." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1471130/.

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Individuals with temporal lobe epilepsy (TLE) have significant material specific episodic memory impairments with greater verbal and visual memory deficits accompanying left and right TLE respectively. More recently, however, widespread cognitive deficits have been described in patients with TLE in keeping with morphological and functional abnormalities that extend beyond the temporal lobes. Functional magnetic resonance imaging (fMRI) has demonstrated reorganisation of memory encoding networks within the temporal lobe in TLE, but little is known of the extra-temporal networks in these patients. Memory fMRI as a tool for predicting memory decline after anterior temporal lobe resection has been explored but a clinically applicable algorithm has yet to be defined. Fewer studies have described the changes in the memory encoding networks after temporal lobe surgery. This thesis presents methodological developments and novel applications to describe the pre-operative and post-operative verbal and visual memory networks in those with unilateral TLE. Pre-operatively, I investigated extra-temporal areas of memory reorganisation in left and right TLE patients, quantitatively compared to healthy controls. Novel findings include the ‘efficiency’ of extra-temporal reorganisation to successful memory formation. Next, using clinical parameters such as age at onset of epilepsy, epilepsy duration and seizure frequency as continuous regressors, I described the factors affecting verbal and visual memory reorganisation in TLE. In a separate pre-operative study, I used an alternative fMRI analysis method, multi-voxel pattern analysis (MVPA) that focuses on the patterns of activity across voxels 4 in specific brain regions that are associated with individual memory traces. I used MVPA-fMRI to assess the functional integrity of the hippocampi and other medial temporal lobe structures in patients with unilateral TLE. Next, I explored the predictive ability of temporal and extra-temporal activations in predicting post-operative verbal memory decline in left and right TLE patients and described a method of using memory fMRI as a clinically applicable tool in patients who had anterior temporal lobe resection. Finally, I explored memory encoding network plasticity four and 12 months after anterior temporal lobe resection. In this study, controls were also scanned at similar time intervals to patients. I report for the first time, dynamic changes in the memory encoding network four and 12 months after surgery, relative to changes in controls. Novel findings also include the efficiency of these post-operative networks. In this thesis, I also discuss methodological constraints, clinical applications and future directions.
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Testa, S. Marc. "DEPRESSIVE SYMPTOMS IN TEMPORAL LOBE EPILEPSY." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin997801556.

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Arcot, Desai Sharanya. "Multielectrode microstimulation for temporal lobe epilepsy." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/50384.

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Multielectrode arrays may have several advantages compared to the traditional single macroelectrode brain electrical stimulation technique including less tissue damage due to implantation and the ability to deliver several spatio-temporal patterns of stimulation. Prior work on cell cultures has shown that multielectrode arrays are capable of completely stopping seizure-like spontaneous bursting events through a distributed asynchronous multi-site approach. In my studies, I used a similar approach for controlling seizures in a rat model of temporal lobe epilepsy. First, I developed a new method of electroplating in vivo microelectrode arrays for durably improving their impedance. I showed that microelectrode arrays electroplated through the new technique called sonicoplating, required the least amount of voltage in current controlled stimulation studies and also produced the least amplitude and duration of stimulation artifact compared to unplated, DC electroplated or pulse-plated microelectrodes. Second, using c-fos immunohistochemistry, I showed that 16-electrode sonicoplated microelectrode arrays can activate 5.9 times more neurons in the dorsal hippocampus compared to a single macroelectrodes while causing < 77% the tissue damage. Next, through open-loop multisite asynchronous microstimulation, I reduced seizure frequency by ~50% in the rodent model of temporal lobe epilepsy. Preliminary studies aimed at using the same stimulation protocol in closed-loop responsive and predictive seizure control did not stop seizures. Finally, through an internship at Medtronic Neuromodulation, I worked on developing and implementing a rapid algorithm prototyping research tool for closed-loop human deep brain stimulation applications.
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Petty, Karen Hammack. "Pediatric temporal lobe epilepsy versus frontal lobe epilepsy : how does cognitive performance differ ? /." Full text available from ProQuest UM Digital Dissertations, 2007. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1414130851&SrchMode=1&sid=2&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1221160824&clientId=22256.

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Kemper, Birgit. "Neuropsychologische Untersuchung bei Frontallappenepilepsien ein Vergleich kognitiver Leistungen zwischen Patienten mit Frontal- und Temporallappenepilepsie im Rahmen der prächirurgischen Diagnostik /." Münster : Universität Münster, 1995. http://catalog.hathitrust.org/api/volumes/oclc/64528329.html.

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Books on the topic "Temporal lobe epilepsy"

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M, Ferguson Shirley, Rayport Mark, and Schell Carolyn A, eds. Temporal lobe epilepsy and the mind-brain relationship: A new perspective. San Diego: Elsevier/Academic Press, 2006.

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Janet, Lindsay, and Richards Peronelle, eds. Temporal lobe epilepsy, 1948-1986: A biographical study. London: Mac Keith, 1987.

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LaPlante, Eve. Seized. New York: HarperCollins, 1993.

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A, Arzimanoglou, ed. Cognitive dysfunction in children with temporaral lobe epilepsy. Montrouge, France: John Libbey Eurotext, 2005.

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Philips, Matthew Frank. Synaptic and pathway remodeling of the human Hippocampus in temporal lobe epilepsy. [New Haven, Conn: s.n.], 1993.

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Kumlien, Eva. In vitro and in vivo studies on epileptogenic tissue in temporal lobe epilepsy. Uppsala: Acta Universitatis Upsaliensis, 1994.

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Dare, Amos O. Ouabain potentiates kainate neurotoxicity: A new rat model of human temporal lobe epilepsy. [New Haven, Conn: s.n.], 1996.

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Schofield-king, Jacqueline L. An investigation into the emotional and behavioural difficulties of children with Temporal Lobe Epilepsy. Birmingham: University of Birmingham, 1998.

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Billinton, Andrew. Brain GABA[Beta] receptors and GBR1 mRNA in rat seizure models and human temporal lobe epilepsy. Birmingham: University of Birmingham, 1999.

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Whitebirch, Alexander Craig. Inhibitory-excitatory imbalance in hippocampal subfield cornu ammonis 2 circuitry in a mouse model of temporal lobe epilepsy. [New York, N.Y.?]: [publisher not identified], 2021.

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Book chapters on the topic "Temporal lobe epilepsy"

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Huk, W. J. "Temporal Lobe Epilepsy." In Magnetic Resonance Imaging of Central Nervous System Diseases, 225–28. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-72568-5_9.

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Barr, William B., and Stella Karantzoulis. "Temporal Lobe Epilepsy." In Encyclopedia of Clinical Neuropsychology, 2482–83. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-0-387-79948-3_1058.

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Barr, William B., and Stella Karantzoulis. "Temporal Lobe Epilepsy." In Encyclopedia of Clinical Neuropsychology, 1–2. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56782-2_1058-2.

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Barr, William B., and Stella Karantzoulis. "Temporal Lobe Epilepsy." In Encyclopedia of Clinical Neuropsychology, 3419–21. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-57111-9_1058.

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Damasceno, Benito. "Temporal Lobe Epilepsy." In Research on Cognition Disorders, 207–14. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-57267-9_19.

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Brunette-Clement, Tristan, Aria Fallah, and Alexander G. Weil. "Temporal Lobe Epilepsy." In Pediatric Neurosurgery for Clinicians, 553–92. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-80522-7_38.

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Weibin, Melvyn Zhang, Cyrus Ho Su Hui, Roger Ho, and Basant K. Puri. "Temporal lobe epilepsy." In Get Through MRCPsych CASC, 206–7. 2nd ed. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003313113-72.

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Yoshii-Contreras, June. "Temporal Lobe Epilepsy." In Handbook of Pediatric Epilepsy Case Studies, Second Edition, 369–73. 2nd ed. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003296478-55.

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Stern, John M., and Noriko Salamon. "Temporal Lobe Trauma." In Imaging of Epilepsy, 121–23. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-86672-3_29.

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Tatum, William O. "Medial Temporal Lobe Epilepsy." In Adult Epilepsy, 221–45. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9780470975039.ch14.

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Conference papers on the topic "Temporal lobe epilepsy"

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Ghazi, Nayereh, and Hamid Soltanian-Zadeh. "Structural connectivity of temporal lobe structures detects temporal lobe epilepsy." In 2016 23rd Iranian Conference on Biomedical Engineering and 2016 1st International Iranian Conference on Biomedical Engineering (ICBME). IEEE, 2016. http://dx.doi.org/10.1109/icbme.2016.7890924.

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P., Nishanth, and Rupam Borgohain. "Social Cognition Abilities in Patients with Chronic Temporal Lobe Epilepsy." In 20th Joint Annual Conference of Indian Epilepsy Society and Indian Epilepsy Association. Thieme Medical and Scientific Publishers Private Ltd., 2018. http://dx.doi.org/10.1055/s-0039-1694887.

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Diniz, P. B., C. E. Salmon, T. R. Velasco, A. C. Sakamoto, J. P. Leite, and A. C. Santos. "White matter alterations in temporal lobe epilepsy." In SPIE Medical Imaging, edited by John B. Weaver and Robert C. Molthen. SPIE, 2011. http://dx.doi.org/10.1117/12.877190.

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Lv, Bin, Huiguang He, Jingjing Lu, Wenjing Li, Dai Dai, Meng Li, and Zhengyu Jin. "Altered cortical anatomical networks in temporal lobe epilepsy." In SPIE Medical Imaging, edited by John B. Weaver and Robert C. Molthen. SPIE, 2011. http://dx.doi.org/10.1117/12.877808.

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Siadat, Mohammad-Reza, Hamid Soltanian-Zadeh, Farshad A. Fotouhi, and Kost Elisevich. "Multimodality medical image database for temporal lobe epilepsy." In Medical Imaging 2003, edited by H. K. Huang and Osman M. Ratib. SPIE, 2003. http://dx.doi.org/10.1117/12.481936.

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M., Desai, Rajeshree S., Sapre A., Kalika M., Shah U., and Ravat S. "Subjective Memory Complaints in Temporal Lobe Epilepsy What Contributes to an Experience of Memory Dysfunction?" In 20th Joint Annual Conference of Indian Epilepsy Society and Indian Epilepsy Association. Thieme Medical and Scientific Publishers Private Ltd., 2018. http://dx.doi.org/10.1055/s-0039-1694881.

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Zaveri, H. P., L. D. Iasemidis, W. J. Williams, and J. C. Sackellares. "Multielectrode analysis of the electrocorticogram in temporal lobe epilepsy." In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1988. http://dx.doi.org/10.1109/iembs.1988.94873.

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Iasemidis, L. D., H. P. Zaveri, J. C. Sackellares, and W. J. Williams. "Phase space analysis of EEG in temporal lobe epilepsy." In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1988. http://dx.doi.org/10.1109/iembs.1988.94874.

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Samotaeva, Irina, Nikolay Ierusalimsky, Sabir Burkitbayev, and Flora Rider. "PATTERNS OF BRAIN FUCTIONAL CONNECTIVITY IN TEMPORAL LOBE EPILEPSY." In XVII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2021. http://dx.doi.org/10.29003/m2310.sudak.ns2021-17/333-334.

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Jafari-Khouzani, Kourosh, Hamid Soltanian-Zadeh, and Kost Elisevich. "Hippocampus Volume and Texture Analysis for Temporal Lobe Epilepsy." In 2006 IEEE International Conference on Electro/Information Technology. IEEE, 2006. http://dx.doi.org/10.1109/eit.2006.252120.

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Reports on the topic "Temporal lobe epilepsy"

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Ye, Qing, Quan Wen, Yi-ming Sun, Xin-ru Liu, Yu-xuan Peng, Xueping Yang, and Yu Dai. Resting-state fMRI in temporal lobe epilepsy patients with cognitive impairment: protocol for a meta-analysis and systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2021. http://dx.doi.org/10.37766/inplasy2021.3.0092.

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Liu, Jie, Lun Cai, and Jianhua Tan. Is there a link between cognitive impairment and hippocampal sclerosis in patients with temporal lobe epilepsy: A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2023. http://dx.doi.org/10.37766/inplasy2023.11.0099.

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