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Relevant bibliographies by topics / TEAD COMPLEX

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Academic literature on the topic 'TEAD COMPLEX'

Author: Grafiati

Published: 11 September 2023

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Journal articles on the topic "TEAD COMPLEX"

1

Moure, Casey J., Christopher Sondey, Mangeng Cheng, et al. "Abstract 3938: Discovery of a novel small molecule inhibitor of the YAP1/TAZ-TEAD transcriptional complex." Cancer Research 82, no. 12_Supplement (2022): 3938. http://dx.doi.org/10.1158/1538-7445.am2022-3938.

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Abstract Hippo pathway alterations in human cancers often result in dephosphorylation of yes-associated protein (YAP1) and its paralog TAZ (WWTR1), allowing the formation of an active complex with transcriptional enhanced associate domain transcription factors (TEADs). This complex formation results in the activation of pro-survival and pro-proliferative transcriptional programs in cancer cells. Many tumor types harbor alterations in the Hippo pathway, including mesothelioma, where a high percentage of tumors are driven by YAP1/TEAD activity. Although traditionally difficult to drug with small

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Pobbati, Ajaybabu V., and Brian P. Rubin. "Protein-Protein Interaction Disruptors of the YAP/TAZ-TEAD Transcriptional Complex." Molecules 25, no. 24 (2020): 6001. http://dx.doi.org/10.3390/molecules25246001.

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The identification of protein-protein interaction disruptors (PPIDs) that disrupt the YAP/TAZ-TEAD interaction has gained considerable momentum. Several studies have shown that YAP/TAZ are no longer oncogenic when their interaction with the TEAD family of transcription factors is disrupted. The transcriptional co-regulator YAP (its homolog TAZ) interact with the surface pockets of TEADs. Peptidomimetic modalities like cystine-dense peptides and YAP cyclic and linear peptides exploit surface pockets (interface 2 and interface 3) on TEADs and function as PPIDs. The TEAD surface might pose a chal

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Che, Kepeng, Ajaybabu V. Pobbati, Caleb N. Seavey, et al. "Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex." PLOS ONE 17, no. 4 (2022): e0266143. http://dx.doi.org/10.1371/journal.pone.0266143.

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Disrupting the formation of the oncogenic YAP/TAZ-TEAD transcriptional complex holds substantial therapeutic potential. However, the three protein interaction interfaces of this complex cannot be easily disrupted using small molecules. Here, we report that the pharmacologically active small molecule aurintricarboxylic acid (ATA) acts as a disruptor of the TAZ-TEAD complex. ATA was identified in a high-throughput screen using a TAZ-TEAD AlphaLISA assay that was tailored to identify disruptors of this transcriptional complex. We further used fluorescence polarization assays both to confirm disru

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Gallego-Gutiérrez, Helios, Laura González-González, Leticia Ramírez-Martínez, Esther López-Bayghen, and Lorenza González-Mariscal. "Tight junction protein ZO-2 modulates the nuclear accumulation of transcription factor TEAD." Molecular Biology of the Cell 32, no. 15 (2021): 1347–58. http://dx.doi.org/10.1091/mbc.e20-07-0470.

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ZO-2 interaction with TEAD regulates TEAD movement in and out of the nucleus. nPKCδ blocks formation of ZO-2/TEAD complex. PKA blocks ZO-2 nuclear import. nPKCε activates a NES of ZO-2 and TEAD exportation in a complex with ZO-2 or alone.

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Li, Z., B. Zhao, P. Wang, et al. "Structural insights into the YAP and TEAD complex." Genes & Development 24, no. 3 (2010): 235–40. http://dx.doi.org/10.1101/gad.1865810.

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Kim, Jisook, Seung Hyun Jung, Seon Yeong Han, et al. "Abstract 1614: Antitumor activity of novel and potent YAP/TAZ-TEAD inhibitorstargeting the Hippo pathway in solid tumors." Cancer Research 83, no. 7_Supplement (2023): 1614. http://dx.doi.org/10.1158/1538-7445.am2023-1614.

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Abstract The Hippo pathway is evolutionarily conserved and known to regulate diverse cellular processes, including cell survival, proliferation, differentiation, migration, and organ size. The key regulator of Hippo pathway is transcriptional enhanced associate domain (TEAD) transcription factors, which directly bind with YAP/TAZ and then drive the multiple signaling by activating target gene expression on nuclear. Loss-of-function mutations in the upstream activators, NF2-LATS1/2-MST1/2, trigger YAP/TAZ nuclear translocation and target gene transcription (Hippo-off state). This YAP/TAZ-TEAD c

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Lauriola, Angela, Elisa Uliassi, Matteo Santucci, et al. "Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library." Pharmaceutics 14, no. 2 (2022): 391. http://dx.doi.org/10.3390/pharmaceutics14020391.

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The transcriptional regulators YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) are the major downstream effectors in the Hippo pathway and are involved in cancer progression through modulation of the activity of TEAD (transcriptional enhanced associate domain) transcription factors. To exploit the advantages of drug repurposing in the search of new drugs, we developed a similar approach for the identification of new hits interfering with TEAD target gene expression. In our study, a 27-member in-house library was assembled, characterized, and screened

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Sheldon, Caroline, Aaron Farley, Qing Ma, William T. Pu, and Zhiqiang Lin. "Depletion of VGLL4 Causes Perinatal Lethality without Affecting Myocardial Development." Cells 11, no. 18 (2022): 2832. http://dx.doi.org/10.3390/cells11182832.

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Congenital heart disease is one of the leading causes of pediatric morbidity and mortality, thus highlighting the importance of deciphering the molecular mechanisms that control heart development. As the terminal transcriptional effectors of the Hippo–YAP pathway, YAP and TEAD1 form a transcriptional complex that regulates the target gene expression and depletes either of these two genes in cardiomyocytes, thus resulting in cardiac hypoplasia. Vestigial-like 4 (VGLL4) is a transcriptional co-factor that interacts with TEAD and suppresses the YAP/TEAD complex by competing against YAP for TEAD b

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Zhang, Wenxiang, Jinjin Xu, Jinhui Li, et al. "The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex." Journal of Biological Chemistry 293, no. 44 (2018): 17119–34. http://dx.doi.org/10.1074/jbc.ra118.003608.

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The Hippo signaling pathway is known to play an important role in multiple physiological processes, including adipogenesis. However, whether the downstream components of the Hippo pathway are involved in adipogenesis remains unknown. Here we demonstrate that the TEA domain family (TEAD) transcription factors are essential for adipogenesis in murine 3T3-L1 preadipocytes. Knockdown of TEAD1–4 stimulated adipogenesis and increased the expression of adipocyte markers in these cells. Interestingly, we found that the TEAD4 knockdown–mediated adipogenesis proceeded in a Yes-associated protein (YAP)/T

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Gnedeva, Ksenia, Xizi Wang, Melissa M. McGovern, et al. "Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal." Proceedings of the National Academy of Sciences 117, no. 24 (2020): 13552–61. http://dx.doi.org/10.1073/pnas.2000175117.

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Precise control of organ growth and patterning is executed through a balanced regulation of progenitor self-renewal and differentiation. In the auditory sensory epithelium—the organ of Corti—progenitor cells exit the cell cycle in a coordinated wave between E12.5 and E14.5 before the initiation of sensory receptor cell differentiation, making it a unique system for studying the molecular mechanisms controlling the switch between proliferation and differentiation. Here we identify the Yap/Tead complex as a key regulator of the self-renewal gene network in organ of Corti progenitor cells. We sho

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Dissertations / Theses on the topic "TEAD COMPLEX"

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Stapleton, James L. "Joint effects of team composition and team decision mode on complex decision quality /." Available to subscribers only, 2006. http://proquest.umi.com/pqdweb?did=1147183151&sid=11&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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Rovira, Asenjo Núria. "Complex network approaches to small team analysis. Conflict and gender." Doctoral thesis, Universitat Rovira i Virgili, 2014. http://hdl.handle.net/10803/130926.

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En un contexto donde los equipos juegan un papel cada vez más importante, es de gran importancia entender el conflicto y desarrollar herramientas de diagnóstico para evitarlo. Aquí, investigamos empíricamente si es posible predecir cuantitativamente futuros conflictos en equipos pequeños utilizando modelos de estructura de red social. Analizamos los datos de 16 equipos pequeños. Encontramos que los modelos basados en redes complejas anticipan el conflicto exitosamente mientras que los modelos utilizados tradicionalmente no lo hacen. También presentamos un estudio sobre las diferencias de géner

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Stevenson, David M. "Decision making skill and complex problem solving in team sports." Thesis, University of Stirling, 2013. http://hdl.handle.net/1893/20389.

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This thesis aimed to enhance understanding of the nature of knowledge bases possessed by elite sports performers which underpin perceptual-cognitive and decision making skills. Two main theories were considered; Active Control of Thought (ACT*) and Representational Redescription (RR). The purpose of Study 1 was to examine the anticipatory ability of elite and non-elite players in football and hockey. The results indicated that elite players in both sports were quicker and more accurate in their expectation of pass destination. Study 2 aimed to understand the extent to which knowledge is transf

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Gibault, Floriane. "Conception, synthèse et évaluation d’inhibiteurs du complexe protéique YAP-TEAD à visée anticancéreuse." Thesis, Lille 1, 2017. http://www.theses.fr/2017LIL10097.

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La voie Hippo, découverte chez la Drosophile et conservée chez les mammifères, a été identifiée comme un élément essentiel dans le contrôle de la taille des organes. Cette cascade de kinases régule la phosphorylation de l’effecteur terminal YAP (ou de son paralogue TAZ), un coactivateur transcriptionnel reconnu comme oncogène. Sa fonction est médiée par sa translocation nucléaire et son interaction avec les facteurs de transcription TEAD, pour former le complexe YAP-TEAD qui active l’expression des gènes cibles responsable de la prolifération cellulaire et de la croissance des organes. La sure

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Sperling, Brian Keith. "Information Sharing Strategies To Improve Team Mental Models In Complex Systems." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/6975.

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This thesis hypothesizes that providing task specific information to individual team members will improve coordination and decision-making, and therefore team performance, at time critical tasks. Major themes addressed in this research include teams and team processes, mental models, team mental models, work domain analysis, and hierarchical task analysis. Furthermore, the theory behind the development of complementary models is introduced. A unique method to identify the information sources and requirements in a complex team environment is first discussed in general and then specifically a

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Obanda, Aston Martin. "The oxidation of simple and complex polyphenols by laccase." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46476.

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Krishnaswami, Ram 1966. "System team composition for a complex system to enable integration and attribute management." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/34799.

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Thesis (S.M.)--Massachusetts Institute of Technology, System Design & Management Program, June 2004.<br>"May 2004."<br>Includes bibliographical references (p. 89).<br>The automatic transmission is a very complex system in a modern automobile with several hundred components performing mechanical, hydraulic and electronic functions. System integration and attribute management are key challenges in the design and development of an automatic transmission. The system and sub system team structure can play a key part in the success of this development. A properly structured team can enhance the comm

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Williams, Alicia, Millie Wykoff, Ryan Tewell, Jodi Polaha, and Jim Holt. "Harmonizing Clinical, Research, and Teaching Aims: Team Care for Patients with Complex Needs." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/6447.

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At the conclusion of this session, the participants will be able to: 1. Describe a team-based approach to addressing complex patients’ needs. 2. Develop engaged and experiential methods for teaching interprofessional learners about team-care for complex patients. 3. Demonstrate familiarity with an evaluation strategy and preliminary outcomes data for a team approach for complex patients.

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Kim, Youngmok. "Factors influencing antioxidant phytochemical stability of teas." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3172.

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Buselmeier, Billy, and Jodi Polaha. "A Team Approach to Patients With Complex Health and Social Needs in Primary Care." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/6554.

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Books on the topic "TEAD COMPLEX"

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1983-, Medina Paco, Checchetto Marco, Vlasco Juan, Curiel David colorist, Rosenberg Rachelle, and Caramagna Joe, eds. Superior Spider-Man team-up: Superiority complex. Marvel Worldwide, 2013.

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Jiang, Silis Y. A Team-Based Approach to Studying Complex Healthcare Processes. [publisher not identified], 2017.

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Eduardo, Salas, Goodwin Gerald F, and Burke C. Shawn, eds. Team effectiveness in complex organizations: Cross-disciplinary perspectives and approaches. Psychology Press, 2008.

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L' affaire Lindros: Dossier complexe et peu reluisant. Guy Saint-Jean, 1992.

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The team selling solution: Creating and managing teams that win the complex sale. McGraw-Hill, 2004.

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Washington State Library. Gateways Team. [Academic library statistics] / compiled by Washington State Library Gateways Team. Washington State Library, 1996.

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Ted, Weiss, and United States. General Accounting Office. Human Resources Division, eds. Homelessness: A complex problem and the federal response : report to the Honorable Ted Weiss, House of Representatives. The Office, 1985.

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1970-, Murphy Naomi, and McVey Des 1962-, eds. Treating personality disorder: Creating robust services for people with complex mental health needs. Routledge, 2010.

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Limbrick, Peter. Early support for children with complex needs: Team around the child and the multi-agency keyworker : a manual for service development. Interconnections, 2004.

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Limbrick, Peter. The team around the child: Multi-agency service coordination for children with complex needs and their families : a manual for service development. Interconnections, 2001.

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Book chapters on the topic "TEAD COMPLEX"

1

Coumbe-Lilley, John E. "Team toughness." In Complex Cases in Sport Psychology. Routledge, 2018. http://dx.doi.org/10.4324/9781315178882-17.

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Coumbe-Lilley, John E. "Team building." In Complex Cases in Sport Psychology. Routledge, 2018. http://dx.doi.org/10.4324/9781315178882-18.

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Coumbe-Lilley, John E. "Team development." In Complex Cases in Sport Psychology. Routledge, 2018. http://dx.doi.org/10.4324/9781315178882-19.

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Kaven, Emily, Ilana Kaven, Diego Gómez-Zará, Leslie DeChurch, and Noshir Contractor. "Assessing How Team Task Influences Team Assembly Through Network Analysis." In Complex Networks & Their Applications IX. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-65351-4_26.

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Chong, Aun-Yeong, Terry Meadows, and David Glineur. "Complex Coronary Revascularization Heart Team." In Heart Teams for Treatment of Cardiovascular Disease. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-19124-5_2.

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Coumbe-Lilley, John E. "Staying with or leaving a team." In Complex Cases in Sport Psychology. Routledge, 2018. http://dx.doi.org/10.4324/9781315178882-8.

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Bowers, Clint, and Janis Cannon-Bowers. "Cognitive Readiness for Complex Team Performance." In Teaching and Measuring Cognitive Readiness. Springer US, 2013. http://dx.doi.org/10.1007/978-1-4614-7579-8_16.

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Aungurenci, Sorin, and Aurel Chiriac. "Integrated Product Team in Large Scale and Complex Systems." In Complex Systems Design & Management. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-02812-5_24.

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Keir, Denise. "Rehabilitation — complex values of a limitless team." In Rehabilitation of Older People. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-2987-7_4.

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Smith-Jentsch, Kimberly A., Joan H. Johnston, and Stephanie C. Payne. "Measuring team-related expertise in complex environments." In Making decisions under stress: Implications for individual and team training. American Psychological Association, 1998. http://dx.doi.org/10.1037/10278-003.

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Conference papers on the topic "TEAD COMPLEX"

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Hossain, Mohammad Abul. "Sorption Dynamics of Cr(VI) on Used Black Tea Leaves." In SLOW DYNAMICS IN COMPLEX SYSTEMS: 3rd International Symposium on Slow Dynamics in Complex Systems. AIP, 2004. http://dx.doi.org/10.1063/1.1764183.

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Hunt, Paul, and Sophie Skellett. "12 Improving teamwork in a paediatric clinical emergency team." In GOSH Conference 2019, Care of the Complex Child. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-gosh.12.

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Carff, John, Matthew Johnson, Eman M. El-Sheikh, and Jerry E. Pratt. "Human-robot team navigation in visually complex environments." In 2009 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2009). IEEE, 2009. http://dx.doi.org/10.1109/iros.2009.5354321.

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Kieras, David E., and Thomas P. Santoro. "Computational GOMS modeling of a complex team task." In the 2004 conference. ACM Press, 2004. http://dx.doi.org/10.1145/985692.985705.

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Sancho-Parramon, Jordi, Vesna Janicki, Matej Bubaš, et al. "Tuning the optical response of complex metal islands films for near infrared coatings." In Optical Interference Coatings. Optica Publishing Group, 2022. http://dx.doi.org/10.1364/oic.2022.tea.3.

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Different approaches for tailoring the effective optical constants of complex island films in the near-infrared range are presented. Nearly-percolated films with finely tuned optical properties may be used as highly-lossy materials in novel optical coatings.

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Torres, M. R. Martinez, S. L. Toral, M. Perales, and F. Barrero. "Analysis of the Core Team Role in Open Source Communities." In 2011 International Conference on Complex, Intelligent and Software Intensive Systems (CISIS). IEEE, 2011. http://dx.doi.org/10.1109/cisis.2011.25.

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Moore, Tamara, Heidi Diefes-Dux, and P. K. Imbrie. "Assessment of Team Effectiveness During Complex Mathematical Modeling Tasks." In Proceedings. Frontiers in Education. 36th Annual Conference. IEEE, 2006. http://dx.doi.org/10.1109/fie.2006.322481.

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Wang, Juan-Ru, and Jin Yang. "Study on Knowledge Integration of Complex Product Development Team." In 2010 International Conference on Management and Service Science (MASS 2010). IEEE, 2010. http://dx.doi.org/10.1109/icmss.2010.5577176.

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Vlasceanu, Emilian, Dan Popescu, and Loretta Ichim. "Aerial Robotic Team for Complex Monitoring in Precision Agriculture." In 2019 15th International Conference on Distributed Computing in Sensor Systems (DCOSS). IEEE, 2019. http://dx.doi.org/10.1109/dcoss.2019.00044.

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Reardon, Christopher, and Jonathan Fink. "Air-ground robot team surveillance of complex 3D environments." In 2016 IEEE International Symposium on Safety, Security, and Rescue Robotics (SSRR). IEEE, 2016. http://dx.doi.org/10.1109/ssrr.2016.7784322.

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Reports on the topic "TEAD COMPLEX"

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Terranova, M. Team-computer interfaces in complex task environments. Office of Scientific and Technical Information (OSTI), 1990. http://dx.doi.org/10.2172/6427485.

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Sperling, Brian K., Amy Pritchett, Arthur Estrada, and Gina E. Adam. Information Distribution in Complex Systems to Improve Team Performance. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada442749.

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Ntuen, Celestine A. An Experiment in Collaborative Team Decision Making in Complex Information Processing Environments. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada445386.

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Beshouri, Greg. PR-309-14212-R01 Field Demonstration of Fully Integrated NSCR System. Pipeline Research Council International, Inc. (PRCI), 2019. http://dx.doi.org/10.55274/r0011545.

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Local, state and federal regulations in the United Sates tend to favor NSCR as the emissions control technology of choice for lower output internal combustion (IC) engines. The technology can achieve extremely low emissions levels for NOx, CO and total hydrocarbons (THC). Theoretically an end user can add it on to any rich burn engine at relatively low cost and the technology scales down to the smallest IC engines. While superficially a "simple and proven" technology, NSCR control is in fact extremely complex, far more complex than the control of lean burn engines. The underlying problems with

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Day, Eric A., Jr Arthur, Bell Winfred, et al. Assessing the Impact of Ability-Based Pairing Strategies in Team Training of a Complex Skill. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada472611.

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Shanteau, James, Clive J. Fullagar, and Scott Hemenover. Selecting and Classifying the Good Sailor Exploring the Non-Cognitive Predictors of Expert Team Performance in Complex Technological Contexts. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada409067.

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Worley, D. R. Challenges to Train, Organize, and Equip the Complete Combined Arms Team: The Joint Task Force. Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/ada372524.

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Knox, Sally, Kïrsten Way, and Alex Haslam. Are identity leadership and shared social identity associated with the highly reliable behaviour of military personnel? Protocol for a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.5.0063.

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Review question / Objective: Are identity leadership and shared social identity associated with the highly reliable behaviour of military personnel? Information sources: Searches will be conducted in the following databases: PsychInfo, Web of Sciences, Proquest Social Science Database, PTSDpubs, PubMed, Business Source Complete, and SCOPUS. To ensure literature saturation, the eligible papers and reviews identified through the search will be used for reference mining. A bibliography of the eligible papers will be circulated to the systematic review team and social identity experts identified b

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Lees-Deutsch, Liz, Mark Ellis, and Andy Aldridge. Reducing in Hospital Length of Stay (RiHLOS) of Alliance 16 Report. Coventry University, 2021. http://dx.doi.org/10.18552/rihw/2021/0001.

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Introduction This paper evaluates the Alliance 16 (A16) collaborative led by Emergency Care Implementation Support Team (ECIST) during 2021, which had the aim of reducing in hospital length of stay (RiHLOS). A16 was a centrally funded programme managed collaborative, with sixteen sites selected for inclusion through regional nomination from each of the seven regions. The work focused on measures to improve patient discharge from hospital and length of stay. Evaluation of any measures on this scale is relatively complex due to the heterogeneity differences of the hospital sites, clinical areas

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Morais, Carla, António Coelho, Alexandre Jacinto, and Marta Varzim, eds. The I SEA Project: Digital Publications. Faculdade de Ciências da Universidade do Porto, 2020. http://dx.doi.org/10.24840/2020/978-989-746-279-5.

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The I SEA project aimed at the development of a non-obtrusive, valid and replicable method to evaluate audience attitudes about science communication projects through an immersive virtual reality environment that can improve exhibitions while educating and empowering citizens. To achieve the objectives of this highly complex, highly interdisciplinary, and innovative project, a permanent articulation of the scientific approach with the technical and design development took place, aiming the construction of the non- invasive evaluation method. Because it is an intricate project, it required cons

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