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Journal articles on the topic 'TCM'

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Author: Grafiati

Published: 4 June 2021

Last updated: 31 January 2023

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1

Arty, Indyah Sulistyo. "SYNTHESIZE AND CITOTOXICITY TEST OF SEVERAL COMPOUNDS OF MONO PARA-HIDROXY CHALCON." Indonesian Journal of Chemistry 10, no. 1 (June 21, 2010): 110–15. http://dx.doi.org/10.22146/ijc.21489.

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Five compounds of mono para-hidroxy chalcon were synthesized (TC1, TC2, TC3, TC4, and TC5) and tested their cytotoxicity against HeLa cell and Raji cell. The difference in substituent of TC1 (R4 =H), TC2 (R4 = OCH3), and TC3 (R4 = F), showed the difference of their citotoxicity against HeLa cell. The citotoxicity of TC1 (LC50 = 16.08 µg/mL) ≈ TC3 (LC50 = 13.37 µg/mL), but the substituent difference of TC2 (LC50 = 147.43 µg/mL), decreasing it citotoxicity 10 times. Like wise their citotoxicity against Raji cell of TC1 (LC50 = 36.44 µg/mL) ≈ TC3 (LC50 = 30.46 µg/mL), but the substituent difference of TC2 (LC50 = 468.94 µg/mL), decreasing it citotoxicity activity 15 times. Nevertheless the strength of citotoxicity TC4 (LC50 = 98.74 µg/mL) and TC5 (LC50 = 110.97 µg/mL) against Raji cell are stronger than the citotoxicity of two of them against HeLa cell (LC50 of TC4 = none, LC50 of TC5 = 576.53 µg/mL). Keywords: mono para-hidroxy chalcon, HeLa cell, Raji cell, citotoxicity activity

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2

Uruilal, Costanza, Abraham Talahaturuson, Wihelmina Rumahlewang, and Jogeneis Patty. "ISOLASI Trichoderma spp. DAN DAYA ANTAGONISMENYA TERHADAP SCLEROTIUM ROLFSII SACC. PENYEBAB PENYAKIT LAYU PADA TANAMAN CABAI (Capsicum anuum) SECARA IN-VITRO." JURNAL BUDIDAYA PERTANIAN 13, no. 2 (December 1, 2017): 64–67. http://dx.doi.org/10.30598/jbdp.2017.13.2.64.

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The objective of this study is to isolation and agonistic test ability of Trichoderma spp. againts Sclerotium rolfsii Sacc. cause of wilting on pepper plants and has been conducted in Pathogenicity Laboratory Faculty of Agriculture Unpatti. The study use 5 treatment of isolate Trichoderma spp. (Tc3, Tc4, Tc5, Tc6 and Tc7) with 3 replications so that there are 15 experimental units. The results showed that the five isolates Trichoderma spp. has an antagonistic power to S. rolfsii with an average percentage of inhibition of S. rolfsii of 26,01%. Percentage of inhibition bolth of isolate ware not significantly different at 95% level test results between treatment. Average percentage inhibition of S. rolfsii by Trichoderma spp. each treatment was Tc6 = 27,31%, Tc3 = 26,63%, Tc5 = 26,05%, Tc7 = 25,69% and Tc4 = 24,37%. Keywords: antagonism, Trichoderma spp., Sclerotium rolfsii Abstrak Penelitian ini bertujuan mengisolasi dan menguji kemampuan antagonis Trichoderma spp. terhadap Sclerotium rolfsii Sacc. penyebab layu pada tanaman cabai dan telah dilaksanakan di Laboratorium Patogenisitas Fakultas Pertanian Unpatti, dengan menggunakan 5 perlakuan isolat Trichoderma spp. (Tc3, Tc4, Tc5, Tc6 dan Tc7) dengan 3 ulangan sehingga terdapat 15 satuan percobaan. Hasil penelitian menunjukkan bahwa kelima isolat Trichoderma sp. mempunyai daya antagonis terhadap S. rolfsii dengan rata-rata persentase penghambatan S. rolfsii sebesar 26%. Hasil analisis varians pada taraf 95% menunjukkan tidak ada perbedaan nyata antara perlakuan. Rata-rata persentase penghambatan S. rolfsii oleh Trichoderma spp. masing-masing perlakuan berturut-turut adalah Tc6 = 27,31%, Tc3 = 26,63%, Tc5 = 26,05%, Tc7 = 25,69% dan Tc4 = 24,37%, dengan rata-rata 26,01%. Kata kunci: antagonisme, Trichoderma spp., Sclerotium rolfsii

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3

Dell, Esther Y. "TCM." Health Care on the Internet 4, no. 1 (January 2000): 63–67. http://dx.doi.org/10.1300/j138v04n01_08.

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4

Shi, Xuefeng, Dawei Zhu, Stephen Nicholas, Baolin Hong, Xiaowei Man, and Ping He. "Is Traditional Chinese Medicine “Mainstream” in China? Trends in Traditional Chinese Medicine Health Resources and Their Utilization in Traditional Chinese Medicine Hospitals from 2004 to 2016." Evidence-Based Complementary and Alternative Medicine 2020 (May 31, 2020): 1–8. http://dx.doi.org/10.1155/2020/9313491.

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Background. Traditional, complementary, and alternative medicine (TCAM) has attracted increasing attention in developed countries, but its mainstream status in China, the home of TCAM, is unclear. Over the period of 2004–2016, we analyze the health resources and health resource utilization of traditional medicine in traditional Chinese medicine (TCM) hospitals in China. Methods. Over 2004–2016, we obtained data from all TCM hospitals in all Chinese provinces to create a hospital-based, longitudinal dataset. TCM health resources and their utilization were measured by two outcome variables: (1) primary outcome variables comprising the proportion of TCM physicians, TCM pharmacists, revenue from TCM drugs, and TCM prescriptions and (2) the secondary outcome variables, as proxies of westernization for TCM hospitals, comprising the number of medical equipment above RMB 10,000 and the proportion of surgery in inpatient visits. We used linear regression models with hospital-fixed effects to analyze time trends for the outcome variables. Results. The number of public TCM hospitals remained stable from 2004 to 2016, while the number of private TCM hospitals increased from 294 in 2004 to 1560 in 2016. There was a small percentage increase in the proportion of TCM physicians (0.280%), TCM pharmacists (0.298%), and revenue from Chinese medicines (0.331%) and TCM prescriptions (1.613%) per hospital per year. Chinese drugs accounted for less than a half of the total drug prescriptions, and accordingly, just one-third of the drug revenue was from Chinese medicines at TCM hospitals. The proportions of physicians, pharmacists, revenue from Chinese drug sales, and traditional medicine prescriptions never reach the 60% benchmark target for mainstream in TCM hospitals. As proxies for Western medicine practices in TCM hospitals, the number of medical equipment above RMB 10,000 rapidly rose by over 13 percent per hospital per year, but the proportion of inpatient surgeries declined by 0.830 percentage points per hospital per year, reflecting a mixed trend in the use of Western medicine practices. Conclusion. For the 2004–2016 period, traditional medicine, although making progress towards the mainstream benchmark of 60% TCM services, was still not mainstream at TCM hospitals.

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5

Mo, Wenjian, Jieling Jiang, Yiqun Jiao, Divino DeOliveira, Nelson J. Chao, and Benny J. Chen. "Central Memory T Cells That Express High Level Of CD44 Mediate Strong Anti-Tumor Response Without Gvhd." Blood 122, no. 21 (November 15, 2013): 293. http://dx.doi.org/10.1182/blood.v122.21.293.293.

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Abstract Several groups have demonstrated directly and indirectly that central memory T cells (TCM) have decreased ability to induce graft-versus-host disease (GVHD) compared with naïve T cells (TN). We have previously demonstrated that TCM expressing high level of CD44 (CD44high TCM) do not cause GVHD. In this study, we further defined the role of CD4+ and CD8+ subsets of this population in GVHD using the same GVHD model as we used previously (C57BL/6→BALB/c). While all CD4+ TN recipients developed lethal GVHD and died within 28 days after transplantation, none of the recipients of CD4+CD44high TCM developed GVHD and all survived more than 100 days after transplantation (P<0.01). Similarly, 36% of CD8+ TN recipients developed lethal GVHD but none of CD8+CD44high TCM recipients developed GVHD (P<0.05). One of the unique features of effector memory T cells (TEM) is that these cells are able to facilitate stem cell engraftment and mediate some degree of anti-tumor response without causing GVHD. To test the ability of TCM to deplete host radioresistant T cells, BALB/c recipients were lethally irradiated (8.5 Gy) and transplanted with 1x107 T-cell-depleted (TCD) bone marrow cells together with graded numbers of T cell subsets from C57BL/6. Host T cells persist in all mice receiving only TCD bone marrow cells. Addition of 1x105 of either TN or CD44high TCM to the graft led to 100% depletion of all host radioresistant T cells. In contrast, none of 1x105 TEM recipients and only 50% of 5x105 TEM recipients depleted all host radioresistant T cells. These data indicate that TN and CD44high TCM have equivalent abilities to deplete host radioresistant T cells and both of them are at least 5 times more potent than TEM. To test the ability of CD44high TCM to mediate anti-tumor effects, host-type leukemia/lymphoma cells (BCL1) cells were added to the stem cell graft. All recipients transplanted with TCD bone marrow together with BCL1 cells developed tumor and died within 28 days after transplantation. Addition of 1x104 TN and CD44high TCM protected 42% and 36% of the recipients from developing tumor respectively. In contrast, only 7% of TEM recipients were protected (P<0.05) at the same dose level. Similarly, addition of 1x105 TN and CD44high TCM protected 79% and 80% of the recipients from developing tumor respectively. However, only 25% of 1x105 TEM recipients were protected (P<0.01). These data indicate that TN and CD44high TCM have equal anti-tumor activity and both of them are at least 10 times more potent than TEM. Similar results were obtained in CD8 subset of CD44high TCM. A critical question is why CD44high TCM are able to kill host radioresistant T cells and tumor cells so efficiently without inducing GVHD. Even though CD44high TCM were able to respond to alloantigens, bioluminescence imaging analyses suggest that CD44high TCM also mediate an abortive alloresponses upon transfer into allogeneic recipients. Using an in vivo functional assay, we further demonstrated that alloreactive CD44high TCM lost the reactivity over time, suggesting a mechanism by which CD44high TCM were able to eliminate host resistance without causing GVHD. In conclusion, these data demonstrate that selective transplantation of CD44high TCM is able to efficiently separate anti-tumor effects from GVHD. Disclosures: No relevant conflicts of interest to declare.

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Hohmann, Uwe, Winfried Busch, Katia Badaeva, Bernd Friebe, and Bikram S. Gill. "Molecular cytogenetic analysis of Agropyron chromatin specifying resistance to barley yellow dwarf virus in wheat." Genome 39, no. 2 (April 1, 1996): 336–47. http://dx.doi.org/10.1139/g96-044.

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Nine families of bread wheat (TC5, TC6, TC7, TC8, TC9, TC10, TC14, 5395-(243AA), and 5395) with resistance to barley yellow dwarf virus and containing putative translocations between wheat and a group 7 chromosome of Agropyron intermedium (L1 disomic addition line, 7Ai#1 chromosome) induced by homoeologous pairing or tissue culture were analyzed. C-banding, genomic in situ hybridization (GISH), and restriction fragment length polymorphism (RFLP) in combination with repetitive Agropyron-specific sequences and deletion mapping in wheat were used to determine the relative locations of the translocation breakpoints and the size of the transferred alien chromatin segments in hexaploid wheat–Agropyron translocation lines. All homoeologous compensating lines had complete 7Ai#1 or translocated 7Ai#1–7D chromosomes that substitute for chromosome 7D. Two complete 7Ai#1 (7D) substitution lines (5395-(243AA) and 5395), one T1BS–7Ai#1S∙7Ai#1L addition line (TC7), and two different translocation types, T7DS–7Ai#1S∙7Ai#1L (TC5, TC6, TC8, TC9, and TC10) and T7DS∙7DL–7Ai#1L (TC14), substituting for chromosome 7D were identified. The substitution line 5395-(243AA) had a reciprocal T1BS∙1BL–4BS/T1BL–4BS∙4BL translocation. TC14 has a 6G (6B) substitution. The RFLP data from deletion mapping studies in wheat using 37 group 7 clones provided 10 molecular tagged chromosome regions for homoeologous and syntenic group 7 wheat or Agropyron chromosomes. Together with GISH we identified three different sizes of the transferred Agropyron chromosome segments with approximate breakpoints at fraction length (FL) 0.33 in the short arm of chromosome T7DS–7Ai#1S∙7Ai#1L (TC5, TC6, TC8, TC9, and TC10) and another at FL 0.37 of the nonhomoeologous translocated chromosome T1BS–7Ai#1S∙7Ai#1L (TC7). One breakpoint was identified in the long arm of chromosome T7DS∙7DL–7Ai#1L (TC14) at FL 0.56. We detected some nonreciprocal translocations for the most proximal region of the chromosome arm of 7DL, which resulted in small duplications. Key words : C-banding, genomic in situ hybridization (GISH), physical mapping, translocation mapping, RFLP analysis.

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7

Li, P. "The assessment of randomized double blind clinical trial of Shugan-liangxue prescription used for the treatment of hot flashes in breast cancer patients." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 8584. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.8584.

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8584 Background: Hot flashes are a common side effect for breast cancer (BC) pts with TAM treatment. Traditional Chinese medicine (TCM) is typically given to BC pts in China. This trial is to assess the effects of TCM for relieving hot flashes. TCM oral solution is prescribed for clearing heat and cooling blood. The compound was tested and contained no phytoestrogen. A randomized, double blind clinical trial was designed to examine the effects of TCM over a 3-week period. Methods: From October 2004 to October 2005, 49 BC pts undergoing treatment with TAM who having hot flashes at least 3 times a day involved the study. Daily average of hot flashes was recorded by the pts for a week as a baseline. TCM or placebo liquid (100 ml) was administered orally three times a day for 3 weeks by a randomized double-blind method. The number of hot flashes and quantity of sleep disturbance in the two groups were evaluated. Results: 45 pts were evaluated in TCM group (n = 22) and the placebo group (n = 23). The severity of the hot flash symptoms was evaluated according to the Kupperman menopausal index (KI). Pts were distributed approximately equally between the two groups. There were 31% (7/22) and 26% (6/23)pts with mild hot flashes in TCM and placebo groups, and 68% (15/22) and 73% (17/23) with severe hot flashes in TCM and placebo groups. Hot flash relief was described as either symptom disappearing, a decrease from severe to mild symptoms, or no change. In TCM group, 50% showed no change, 27% decrease and 23% symptoms disappearing. In the placebo group, 70% no change, 30% decrease and no pts reporting symptoms disappearing. A statistically significant difference exists between the two groups (P < 0.05). In TCM group, 73% of pts sleep improvement compared to 35% in the placebo group (P < 0.05). No adverse events or any side effects were reported. Conclusion: The oral solution of TCM is effective in alleviating tamoxifen-induced hot flashes and sleep disturbance. The study of the drug’s mechanism and an expanded clinical trial are underway. No significant financial relationships to disclose.

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8

Bhattacharya, Manisha, Regina Graziano, Evanne Wahal, Julie Alexander, Lynne O'Connor, Rene Cumberledge, Avigayil East, Dan Paul Zandberg, and Roby Antony Thomas. "Supporting high-risk oncology patients with an outpatient transitional care management program." Journal of Clinical Oncology 40, no. 28_suppl (October 1, 2022): 313. http://dx.doi.org/10.1200/jco.2022.40.28_suppl.313.

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313 Background: Transitional Care Management initiatives (TCM) financially support comprehensive outpatient followup in the first 30 days after acute care discharge. TCM programs require patient contact within 2 days of discharge, an outpatient appointment within 7-14 days, patient education, and moderate-high complexity medical decision-making that supports successful outpatient transition. To date, TCM is often utilized to provide additional reimbursement for qualifying primary care post-discharge followup, but could be applied to align incentives in busy oncology practices. We present a novel application of TCM to enhance post-discharge cancer care with the goal of reducing readmissions for high-risk oncology patients. Methods: We identified patients discharged from our health system’s cancer hospital with a “Highest” risk of readmission as determined by an internally developed machine learning clinical algorithm built into the EMR. Patients were targeted with a post-discharge phone call within 48 hours offering an in-person or telemedicine appointment within 72 hours. The Transitional Care Clinic (TCC) visit guidelines promote connection to ancillary services such as physical and occupational therapy, medication management, and dietetics. The TCC can offer interventions to address emergent medical needs such as fluids, transfusions, and symptom management. Results: In the first three months of the TCC program, the 30-day readmission risk algorithm identified 136 cancer patients discharged from the designated cancer hospital in the “Highest” readmission risk category. 121 of those patients were previously admitted within one year. 72 of the 136 “Highest” risk patients were referred to the cancer center TCC workflow and 60 patients were eligible for a TCC appointment. 18 patients had appointments scheduled (30%) with 83% completed (15/18). 22% of scheduled appointments were via telemedicine (4/18) and 100% of these appointments were completed. Conclusions: TCM programs can be adapted to reward timely hospital followup for oncology patients after discharge. TCM requirements overlap with several common elements of readmission reduction initiatives, but EMR tools for identifying patients at highest readmission risk may need additional adaptation into clinic workflows to promote a high capture rate that justifies program support. Future longitudinal cohort analysis will establish if the TCC is able to reduce cancer-related readmissions in high-risk populations.

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Weibo, LU. "“TCM Modernization ”, “lay same emphasize on tcm and wm ” and “integration of tcm and wm”." Chinese Journal of Integrated Traditional and Western Medicine 6, no. 3 (September 2000): 226. http://dx.doi.org/10.1007/bf02950936.

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Geginat, Jens, Antonio Lanzavecchia, and Federica Sallusto. "Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines." Blood 101, no. 11 (June 1, 2003): 4260–66. http://dx.doi.org/10.1182/blood-2002-11-3577.

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Abstract Four human CD8+ T-cell subsets, naive (CCR7+CD45RA+), central memory (TCM, CCR7+CD45RA–), effector memory (TEM, CCR7–CD45RA–), and CD45RA+ effector memory cells (TEMRA, CCR7–CD45RA+) were compared for their capacity to proliferate and differentiate in response to antigen or homeostatic cytokines. Cytokine responsiveness and interleukin-15 receptor expression were low in naive T cells and progressively increased from TCM to TEM and TEMRA. In contrast, the capacity to accumulate in response to T-cell receptor (TCR) or cytokine stimulation showed a reciprocal pattern and was associated with resistance to cell death and Bcl-2 expression. Whereas all TCR-stimulated cells acquired a CD45RA–CCR7– phenotype, cytokine-stimulated cells maintained their phenotype with the exception of TCM cells, which expressed CCR7, CD45RA, and perforin in various combinations. Single CD8+ TCM cells, but not TEM cells, could be expanded with cytokines, and the obtained clones displayed several distinct phenotypes, suggesting that TCM cells are heterogeneous. Consistently, CCR4 expression in the CD8+ TCM pool discriminated CCR4+ type 2 polarized cells (Tc2) and CCR4–CTL precursors. Finally, ex vivo bromodeoxyuridine (BrdU) incorporation experiments revealed that memory subsets have different in vivo proliferation rates, with CCR4–TCM having the highest turnover and TEMRA the lowest. These results show that human CD8+ memory T-cell subsets have different proliferation and differentiation potentials in vitro and in vivo. Furthermore, they suggest that TEMRA cells are generated from a TCM subset upon homeostatic proliferation in the absence of antigen.

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11

Batten, Stuart R., Bernard F. Hoskins, and Richard Robson. "Structures of [Ag(tcm)], [Ag(tcm)(phz)1/2] and [Ag(tcm)(pyz)] (tcm=tricyanomethanide, C(CN)3-, phz=phenazine, pyz=pyrazine)." New Journal of Chemistry 22, no. 2 (1998): 173–75. http://dx.doi.org/10.1039/a707639h.

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12

Migdał-Mikuli, Anna, and Elżbieta Szostak. "Phase Polymorphism of [Mn(DMSO)6](ClO4)2 Studied by Differential Scanning Calorimetry." Zeitschrift für Naturforschung A 60, no. 4 (April 1, 2005): 289–95. http://dx.doi.org/10.1515/zna-2005-0413.

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Abstract Six solid phases of [Mn(DMSO)6](ClO4)2 have been detected by differential scanning calorimetry. The phase transitions were found between the following solid phases: stable KIc ↔ stable KIb at TC5 = 225 K, metastable KIII ↔ metastable KII at TC4 = 322 K, stable KIb ↔ stable KIa at TC3 = 365 K, metastable KII↔overcooled K0 at TC2 = 376 K and stable KIa→stable K0 at TC1 = 379 K. The title compound melts at Tm = 488 K.

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13

Bögel-Witt, Martina. "Die TCM-Pulsdiagnostik." Deutsche Heilpraktiker-Zeitschrift 17, no. 03 (March 2022): 56–62. http://dx.doi.org/10.1055/a-1804-5469.

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SummaryDie Pulsdiagnostik gehört neben Befragen, Betrachten/Inspektion, Zungendiagnostik und Palpieren der Leitbahnen beziehungsweise Körperregionen zu den klassischen Diagnosemethoden der Traditionellen Chinesischen Medizin (TCM). Die Methode ist komplex, benötigt viel Erfahrung und ist in der Beurteilung recht subjektiv, ermöglicht im Gegenzug jedoch sehr differenzierte diagnostische Ergebnisse. Unterschieden werden unter anderem den TCM-Organen entsprechende Pulspositionen und Pulsqualitäten wie „schlüpfrig“, „leer“, „voll“.

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LI, Jing, and Zhen SANG. "TCM Standardization Today." World Journal of Acupuncture - Moxibustion 27, no. 3 (September 2017): 21–56. http://dx.doi.org/10.1016/s1003-5257(17)30136-8.

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Peters, Gustav. "TCM für Einsteiger." Deutsche Zeitschrift für Akupunktur 54, no. 2 (2011): 53. http://dx.doi.org/10.1016/j.dza.2011.04.016.

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Keller, Nicola, and Axel Wiebrecht. "TCM-Grundlagen, Drehscheibe." Deutsche Zeitschrift für Akupunktur 56, no. 2 (2013): 56. http://dx.doi.org/10.1016/j.dza.2013.06.028.

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Thomas, Ots. "Akupunktur versus TCM?" Deutsche Zeitschrift für Akupunktur 47, no. 2 (2004): 3. http://dx.doi.org/10.1078/0415-6412-00047.

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red. "TCM bei Herzinsuffizienz." CardioVasc 17, no. 4 (September 2017): 26. http://dx.doi.org/10.1007/s15027-017-1179-9.

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Stuhr-Wulff, Neele Nishkala. "TCM-Summerschool 2016." Chinesische Medizin / Chinese Medicine 31, no. 4 (December 2016): 233–34. http://dx.doi.org/10.1007/s00052-016-0125-8.

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Batten, Stuart R., Bernard F. Hoskins, and Richard Robson. "Synthesis and Rutilelike Structure of [Cd(tcm)(hmt)(H2O)](tcm) (tcm-= Tricyanomethanide, C(CN)3-; hmt = Hexamethylenetetramine)." Inorganic Chemistry 37, no. 13 (June 1998): 3432–34. http://dx.doi.org/10.1021/ic980059v.

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Li, Sheng-You, Ze-Kun Sun, Xue-Yi Zeng, Yue Zhang, Meng-Ling Wang, Sheng-Cao Hu, Jun-Rong Song, et al. "Potent Cytotoxicity of Novel L-Shaped Ortho-Quinone Analogs through Inducing Apoptosis." Molecules 24, no. 22 (November 15, 2019): 4138. http://dx.doi.org/10.3390/molecules24224138.

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Twenty-seven L-shaped ortho-quinone analogs were designed and synthesized using a one pot double-radical synthetic strategy followed by removing methyl at C-3 of the furan ring and introducing a diverse side chain at C-2 of the furan ring. The synthetic derivatives were investigated for their cytotoxicity activities against human leukemia cells K562, prostate cancer cells PC3, and melanoma cells WM9. Compounds TB1, TB3, TB4, TB6, TC1, TC3, TC5, TC9, TC11, TC12, TC14, TC15, TC16, and TC17 exhibited a better broad-spectrum cytotoxicity on three cancer cells. TB7 and TC7 selectively displayed potent inhibitory activities on leukemia cells K562 and prostate cancer cells PC3, respectively. Further studies indicated that TB3, TC1, TC3, TC7, and TC17 could significantly induce the apoptosis of PC3 cells. TC1 and TC17 significantly induced apoptosis of K562 cells. TC1, TC11, and TC14 induced significant apoptosis of WM9 cells. The structure-activity relationships evaluation showed that removing methyl at C-3 of the furan ring and introducing diverse side chains at C-2 of the furan ring is an effective strategy for improving the anticancer activity of L-shaped ortho-quinone analogs.

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Ajani, Emmanuel Kolawole, Olugbenga Orisasona, Oladeji Kazeem Kareem, Friday Elijah Osho, Aminat Omosalewa Adeyemo, Bamidele Oluwarotimi Omitoyin, and Abimbola Olumide Adekanmbi. "Growth Performance, Gut Ecology, Immunocompetence and Resistance of Oreochromis niloticus Juveniles Fed Dietary Curcumin longa." Croatian Journal of Fisheries 78, no. 3 (September 1, 2020): 145–56. http://dx.doi.org/10.2478/cjf-2020-0014.

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AbstractThe growth, gut ecology and immunocompetence of Oreochromis niloticus and the resistance to Aeromonas hydrophila were investigated after been fed with diets containing dietary Curcumin longa for 12 weeks. Diets were formulated to contain 30% crude protein with diet TC1, TC2, TC3, TC4 and TC5 having 0% (control), 0.25%, 0.5%, 0.75% and 1.0% turmeric powder, respectively. Diets were allotted to groups of O. niloticus (mean weight of 1.29± 0.15 g) and replicated thrice for 84 days. Results showed that the highest mean final weight (4.79±0.04 g) was obtained in TC3 and corresponded to the treatment with the highest feed intake. A significantly high (p<0.05) specific growth rate (SGR) was observed in TC3 (0.73±0.03 %day−1) while TC4 (0.57±0.02 %day−1) gave the lowest value. The highest microbial load in the gut was observed in TC1 groups and the least in TC4 groups. Red blood cell count, hemoglobin, packed cell volume did not show significant variation (p>0.05) across treatments. However, white blood cell (WBC) count was significantly higher in TC1 (control). There was an improved immunocompetence, as aspartate aminotransferase (AST) progressively reduces in fish fed supplements. Similarly, there was a better oxidative response in the treated groups with reduced hydrogen peroxidase, increased total protein and glutathione peroxidase. Mortality ranged from 25% in TC4 to 95% in TC1 after the challenge test with A. hydrophila. This study showed that C. longa inclusion at 0.5% is more beneficial when growth and health status of O. niloticus juveniles are considered.

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Greaves, Ian K., Steven R. Eichten, Michael Groszmann, Aihua Wang, Hua Ying, W. James Peacock, and Elizabeth S. Dennis. "Twenty-four–nucleotide siRNAs produce heritable trans-chromosomal methylation in F1 Arabidopsis hybrids." Proceedings of the National Academy of Sciences 113, no. 44 (October 17, 2016): E6895—E6902. http://dx.doi.org/10.1073/pnas.1613623113.

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Hybrid Arabidopsis plants undergo epigenetic reprogramming producing decreased levels of 24-nt siRNAs and altered patterns of DNA methylation that can affect gene expression. Driving the changes in methylation are the processes trans-chromosomal methylation (TCM) and trans-chromosomal demethylation (TCdM). In TCM/TCdM the methylation state of one allele is altered to resemble the other allele. We show that Pol IV-dependent sRNAs are required to establish TCM events. The changes in DNA methylation and the associated changes in sRNA levels in the F1 hybrid can be maintained in subsequent generations and affect hundreds of regions in the F2 epigenome. The inheritance of these altered epigenetic states varies in F2 individuals, resulting in individuals with genetically identical loci displaying different epigenetic states and gene expression profiles. The change in methylation at these regions is associated with the presence of sRNAs. Loci without any sRNA activity can have altered methylation states, suggesting that a sRNA-independent mechanism may also contribute to the altered methylation state of the F1 and F2 generations.

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Ots, Thomas. "Wellness goes TCM – TCM goes Wellness oder die Globalisierung der Unmoral." Deutsche Zeitschrift für Akupunktur 48, no. 3 (2005): 49. http://dx.doi.org/10.1078/0415-6412-00132.

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Sayaduzzaman, Mohammad, Mao Katsuhara, Hirotada Hoshino, Tadashi Kawamoto, and Takehiko Mori. "Alloyed transition-metal complexes of tricyanomethide(tcm),[Mn1−xCox(tcm)2]." Applied Organometallic Chemistry 18, no. 4 (March 24, 2004): 176–80. http://dx.doi.org/10.1002/aoc.604.

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Huang, Faming, Jianbo Yang, Biao Zhang, Yijing Li, Jinsong Huang, and Na Chen. "Regional Terrain Complexity Assessment Based on Principal Component Analysis and Geographic Information System: A Case of Jiangxi Province, China." ISPRS International Journal of Geo-Information 9, no. 9 (September 8, 2020): 539. http://dx.doi.org/10.3390/ijgi9090539.

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Regional terrain complexity assessment (TCA) is an important theoretical foundation for geological feature identification, hydrological information extraction and land resources utilization. However, the previous TCA models have many disadvantages; for example, comprehensive consideration and redundancy information analysis of terrain factors is lacking, and the terrain complexity index is difficult to quantify. To overcome these drawbacks, a TCA model based on principal component analysis (PCA) and a geographic information system (GIS) is proposed. Taking Jiangxi province of China as an example, firstly, ten terrain factors are extracted using a digital elevation model (DEM) in GIS software. Secondly, PCA is used to analyze the information redundancy of these terrain factors and deal with data compression. Then, the comprehensive evaluation of the compressed terrain factors is conducted to obtain quantitative terrain complexity indexes and a terrain complexity map (TCM). Finally, the TCM produced by the PCA method is compared with those produced by the slope-only, the variation coefficient and K-means clustering models based on the topographic map drawn by the Bureau of Land and Resources of Jiangxi province. Meanwhile, the TCM is also verified by the actual three-dimensional aerial images. Results show that the correlation coefficients between the TCMs produced by the PCA, slope-only, variable coefficient and K-means clustering models and the local topographic map are 0.894, 0.763, 0.816 and 0.788, respectively. It is concluded that the TCM of the PCA method matches well with the actual field terrain features, and the PCA method can reflect the regional terrain complexity characteristics more comprehensively and accurately when compared to the other three methods.

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Chan, Kara, Lennon Tsang, and Yanni Ma. "Consumers’ attitudes toward advertising by traditional Chinese medicine practitioners." Media and communication as antecedents to the transformation agenda in Malaysia 25, no. 2 (December 7, 2015): 305–22. http://dx.doi.org/10.1075/japc.25.2.11cha.

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This study investigated consumers’ attitudes toward advertising by traditional Chinese medicine (TCM) practitioners, and how attitudes varied among different demographic groups and user experiences in TCM. A survey using quota sampling was conducted. Altogether 1,039 adults aged 20 or above in Hong Kong filled in an online questionnaire in March 2014. Factor analysis found that attitudes toward TCM advertising consisted of four underlying dimensions: information value of TCM advertising; benefits of TCM advertising; confidence in financial aspects of TCM; and doubts about TCM advertising. Consumers’ attitudes toward TCM practitioners were in general favorable. Respondents appreciated information value of TCM advertising, but held some skepticism and worries about it. Respondents perceived strongly that advertising by medical professionals would lead to increase in the cost of services. Respondents with TCM consultation experience demonstrated a more positive attitude toward TCM advertising than respondents without TCM experience. Practical implications and limitations were discussed. (149 words)

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Li, Xiao, Dan Wu, Jingjie Niu, Yanping Sun, Qiuhong Wang, Bingyou Yang, and Haixue Kuang. "Intestinal Flora: A Pivotal Role in Investigation of Traditional Chinese Medicine." American Journal of Chinese Medicine 49, no. 02 (January 2021): 237–68. http://dx.doi.org/10.1142/s0192415x21500130.

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Intestinal flora is essential for maintaining host health and plays a unique role in transforming Traditional Chinese Medicine (TCM). TCM, as a bodyguard, has saved countless lives and maintained human health in the long history, especially in this COVID-19 pandemic. Pains of diseases have been removed from the effective TCM therapy, such as TCM preparation, moxibustion, and acupuncture. With the development of life science and technology, the wisdom and foresight of TCM has been more displayed. Furthermore, TCM has been also inherited and developed in innovation to better realize the modernization and globalization. Nowadays, intestinal flora transforming TCM and TCM targeted intestinal flora treating diseases have been important findings in life science. More and more TCM researches showed the significance of intestinal flora. Intestinal flora is also a way to study TCM to elucidate the profound theory of TCM. Processing, compatibility, and properties of TCM are well demonstrated by intestinal flora. Thus, it is no doubt that intestinal flora is a core in TCM study. The interaction between intestinal flora and TCM is so crucial for host health. Therefore, it is necessary to sum up the latest results in time. This paper systematically depicted the profile of TCM and the importance of intestinal flora in host. What is more, we comprehensively summarized and discussed the latest progress of the interplay between TCM and intestinal flora to better reveal the core connotation of TCM.

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Mao, Huisheng, Baozheng Zhang, Hua Xu, and Kai Gao. "An End-to-End Traditional Chinese Medicine Constitution Assessment System Based on Multimodal Clinical Feature Representation and Fusion." Proceedings of the AAAI Conference on Artificial Intelligence 36, no. 11 (June 28, 2022): 13200–13202. http://dx.doi.org/10.1609/aaai.v36i11.21727.

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Traditional Chinese Medicine (TCM) constitution is a fundamental concept in TCM theory. It is determined by multimodal TCM clinical features which, in turn, are obtained from TCM clinical information of image (face, tongue, etc.), audio (pulse and voice), and text (inquiry) modality. The auto assessment of TCM constitution is faced with two major challenges: (1) learning discriminative TCM clinical feature representations; (2) jointly processing the features using multimodal fusion techniques. The TCM Constitution Assessment System (TCM-CAS) is proposed to provide an end-to-end solution to this task, along with auxiliary functions to aid TCM researchers. To improve the results of TCM constitution prediction, the system combines multiple machine learning algorithms such as facial landmark detection, image segmentation, graph neural networks and multimodal fusion. Extensive experiments are conducted on a four-category multimodal TCM constitution dataset, and the proposed method achieves state-of-the-art accuracy. Provided with datasets containing annotations of diseases, the system can also perform automatic disease diagnosis from a TCM perspective.

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Xue, Feifei, Xiaoyong He, Wenzhi Hao, Jiajia Qin, and Jiaxu Chen. "Challenges for the Promotion and Development of Traditional Chinese Medicine in Central and Eastern Europe Under the Belt and Road Initiative." Asian Social Science 16, no. 1 (December 31, 2019): 35. http://dx.doi.org/10.5539/ass.v16n1p35.

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Along with the implementation of the Belt and Road Initiative, traditional Chinese medicine (TCM) is increasingly used and attracts more interest in Central and Eastern Europe (CEE). As an important bridge between different cultures, translation plays a major role in promoting TCM in CEE. However, there are some problems in the translation process hindering further promotion of TCM theories and culture in CEE. First of all, the English translations of TCM classics and textbooks lack universally accepted standards, and the quality of TCM text translation is low. Secondly, TCM translators lack sufficient training in TCM knowledge. Also, the translation of TCM materials lacks cultural connotation. Through analyzing the current problems of TCM translation in CEE, this study proposed three suggestions: strengthening the exchange between the government and experts, regulating the translation of TCM textbooks, and strengthening the training of TCM translators.

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Ahmed, Zubair A., Lauren Koffman, Rebecca Michael, Leasa Baus, Larry Raber, and Irene Katzan. "Abstract W P176: Relationship Between Right-to-Left Shunting and Microembolic Signals on Transcranial Doppler Monitoring." Stroke 45, suppl_1 (February 2014). http://dx.doi.org/10.1161/str.45.suppl_1.wp176.

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Background: Transcranial doppler-monitoring (TCM) has been used to identify patients at risk for embolic stroke and aids in identification of stroke mechanism. Limited data exists on the occurrence of microembolic signals (MES) on TCM and the presence of right-to-left shunting (RLS), most commonly through a patent foramen ovale. Our objective was to determine if a relationship exists between the presence of a RLS on transcranial doppler-bubble (TCB) and MES on TCM, and if the degree of shunting correlated with increased number of MES. Methods: A retrospective chart review was conducted of 113 inpatients that underwent both TCB for the detection of a RLS and TCM during their admission for ischemic stroke at the Cleveland Clinic between 2011 and 2012. TCM was performed for 20 minutes in all patients. Both TCM and TCB used standardized protocols and machines. Data collected included demographics, presence of a shunt, and stroke mechanism. Results: Mean age of the study cohort was 57.9 years and 46.9% were female. RLS on TCB was found in 30.1% of patients and MES were seen on TCM in 33.6% of patients. The occurrence of MES was similar in patients with and without RLS (38.2% vs. 31.6% respectively) (p=0.50). In patients with undetermined stroke mechanism and RLS, there was a trend towards higher occurrence of MES (42.9% vs 30.8%, p=0.35). No significant difference was seen between the occurrence of MES and degree of shunting according to Spencer Grades I-IV (p=0.48). Patients with MES and RLS had an insignificantly greater number of MES than patients without RLS (59.8 vs 10.8. p=0.33). This difference in the number of MES was more pronounced in patients with undetermined stroke etiology (73.1 vs 14.4, p=0.42). Conclusions: There was no overall relationship between RLS and MES on TCM. However, the number of MES in patients with positive TCM was greater in those with a RLS compared to those without RLS, particularly in patients with undetermined stroke mechanism. Although, more data is needed, in patients with strokes of undetermined etiology, the presence of MES on TCD may suggest the presence of a RLS, especially if the number of MES is high.

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"TCM." Deutsche Zeitschrift für Onkologie 40, no. 02 (June 2008): 84–85. http://dx.doi.org/10.1055/s-2008-1044093.

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Liu, Jinlong, Yuchen Wang, Zhidong Qiu, Guangfu Lv, Xiaowei Huang, He Lin, Zhe Lin, and Peng Qu. "Impact of TCM on Tumor-Infiltrating Myeloid Precursors in the Tumor Microenvironment." Frontiers in Cell and Developmental Biology 9 (March 4, 2021). http://dx.doi.org/10.3389/fcell.2021.635122.

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The tumor microenvironment (TME) is composed of tumor cells, blood/lymphatic vessels, the tumor stroma, and tumor-infiltrating myeloid precursors (TIMPs) as a sophisticated pathological system to provide the survival environment for tumor cells and facilitate tumor metastasis. In TME, TIMPs, mainly including tumor-associated macrophage (TAM), tumor-associated dendritic cells (DCs), and myeloid-derived suppressor cells (MDSCs), play important roles in repressing the antitumor activity of T cell or other immune cells. Therefore, targeting those cells would be one novel efficient method to retard cancer progression. Numerous studies have shown that traditional Chinese medicine (TCM) has made extensive research in tumor immunotherapy. In the review, we demonstrate that Chinese herbal medicine (CHM) and its components induce tumor cell apoptosis, directly inhibiting tumor growth and invasion. Further, we discuss that TCM regulates TME to promote effective antitumor immune response, downregulates the numbers and function of TAMs/MDSCs, and enhances the antigen presentation ability of mature DCs. We also review the therapeutic effects of TCM herbs and their ingredients on TIMPs in TME and systemically analyze the regulatory mechanisms of TCM on those cells to have a deeper understanding of TCM in tumor immunotherapy. Those investigations on TCM may provide novel ideas for cancer treatment.

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Coy, P., J. Gadea, R. Romar, C. Matas, and E. Garcia. "Effect of in vitrofertilization medium on the acrosome reaction, cortical reaction, zona pellucida hardening and in vitro development in pigs." Reproduction, August 1, 2002, 279–88. http://dx.doi.org/10.1530/rep.0.1240279.

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Physiological events at the time of fertilization of pig oocytes may differ in vitro depending on the in vitro fertilization (IVF) medium. This hypothesis was tested by in vitro maturation of pig oocytes for 44 h in NCSU-37 medium and thereafter fertilization with frozen-thawed ejaculated spermatozoa. Three different IVF media (TCM-199, Tyrode's albumin lactate pyruvate (TALP) and Tris-buffered medium (TBM)) were used. For the acrosome reaction test, spermatozoa were incubated for 0-150 min in the three IVF media, and the proportion of live acrosome-reacted and acrosome-intact cells was determined by fluorescein isothiocyanate-labelled peanut agglutinin (FITC-PNA) and propidium iodide (PI) staining. The cortical granule density of oocytes was evaluated by confocal microscopy, 2.5 and 5.0 h after culture in each medium in the presence or absence of spermatozoa. Zona pellucida resistance to pronase digestion was also determined in the same groups. The percentages of penetration, monospermy, male pronucleus formation, cleavage and blastocyst formation, and the number of cells per blastocyst after culture were determined. The results indicate that the acrosome reaction occurred much faster in TBM than in TCM-199 or TALP medium. Continuous cortical granule synthesis was observed in the three media when oocytes were incubated in the absence of spermatozoa. The presence of spermatozoa triggered the cortical reaction in a large proportion of oocytes fertilized in TCM-199 and TALP media. On the basis of the duration of pronase digestion, the zona pellucida of oocytes incubated in TCM-199 was harder (407.7 +/- 35.5 s) than that of oocytes cultured in TALP (235.4 +/- 18.2 s) or TBM (189.1 +/- 16.8 s). No zona pellucida hardening was noted in oocytes after insemination in any of the media. The percentages of penetration and cleavage were higher in oocytes cultured in TCM-199 and TALP than in TBM. The percentage of monospermy was higher in TCM-199 and TBM than in TALP. No effect of the medium was shown on the percentage of blastocyst formation or on the number of cells per blastocyst. In conclusion, the results highlight how differently the fertilization events take place in each IVF medium and how far these IVF media still are from achieving biological properties of gametes close to those observed in the physiological setting.

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35

"TCM Receivers Awards." Teaching Children Mathematics 3, no. 1 (September 1996): 38. http://dx.doi.org/10.5951/tcm.3.1.0038.

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36

"TCM Wins Award." Teaching Children Mathematics 5, no. 1 (March 1998): 64. http://dx.doi.org/10.5951/tcm.5.1.0064.

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37

Cooper, Raymond. "TCM Needs TQM!" Journal of Complementary Medicine & Alternative Healthcare 2, no. 3 (May 5, 2017). http://dx.doi.org/10.19080/jcmah.2017.02.555586.

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38

"TCM Editorial Policy." Trends in Cardiovascular Medicine 16, no. 4 (May 2006): A2. http://dx.doi.org/10.1016/s1050-1738(06)00058-2.

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"TCM Editorial Policy." Trends in Cardiovascular Medicine 16, no. 6 (August 2006): A2. http://dx.doi.org/10.1016/s1050-1738(06)00095-8.

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40

"TCM Editorial Policy." Trends in Cardiovascular Medicine 17, no. 1 (January 2007): A2. http://dx.doi.org/10.1016/s1050-1738(06)00182-4.

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41

"TCM Editorial Policy." Trends in Cardiovascular Medicine 17, no. 2 (February 2007): A2. http://dx.doi.org/10.1016/s1050-1738(07)00009-6.

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42

"TCM Editorial Policy." Trends in Cardiovascular Medicine 17, no. 4 (May 2007): A2. http://dx.doi.org/10.1016/s1050-1738(07)00085-0.

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43

"TCM Editorial Policy." Trends in Cardiovascular Medicine 17, no. 5 (July 2007): A2. http://dx.doi.org/10.1016/s1050-1738(07)00122-3.

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44

"TCM Editorial Policy." Trends in Cardiovascular Medicine 17, no. 6 (August 2007): A2. http://dx.doi.org/10.1016/s1050-1738(07)00141-7.

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"TCM Editorial Policy." Trends in Cardiovascular Medicine 17, no. 7 (October 2007): A2. http://dx.doi.org/10.1016/s1050-1738(07)00186-7.

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46

"TCM Editorial Policy." Trends in Cardiovascular Medicine 18, no. 1 (January 2008): A2. http://dx.doi.org/10.1016/s1050-1738(07)00249-6.

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47

"TCM Editorial Policy." Trends in Cardiovascular Medicine 18, no. 2 (February 2008): A2. http://dx.doi.org/10.1016/s1050-1738(08)00009-1.

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48

"TCM Editorial Policy." Trends in Cardiovascular Medicine 18, no. 3 (April 2008): A2. http://dx.doi.org/10.1016/s1050-1738(08)00033-9.

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"TCM Editorial Policy." Trends in Cardiovascular Medicine 18, no. 5 (July 2008): A2. http://dx.doi.org/10.1016/s1050-1738(08)00107-2.

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"TCM Editorial Policy." Trends in Cardiovascular Medicine 18, no. 6 (August 2008): A2. http://dx.doi.org/10.1016/s1050-1738(08)00137-0.

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