Relevant bibliographies by topics / TCA

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'TCA'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 March 2023

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Journal articles on the topic "TCA"

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Harfouche, Tieme Breternitz, Ana Paula Dalla Corte, Marieli Ruza, and Alexandre Behling. "USO DE APLICATIVOS EM SMARTPHONE PARA MEDIÇÕES DE ÁRVORES." BIOFIX Scientific Journal 4, no. 1 (January 6, 2019): 07. http://dx.doi.org/10.5380/biofix.v4i1.62532.

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Este trabalho visou verificar a precisão de aplicativos de smartphone para medir indiretamente a altura de árvores e a distância entre o operador e a árvore. Como testemunha para medir altura, adotou-se o Hipsômetro Vertex IV (T0a) e, para distância, a variável medida com trena (T0b). Foram selecionadas 30 árvores isoladas do Campus da Universidade Federal do Paraná em Curitiba - PR e 30 árvores pertencentes à um plantio de Eucalyptus sp. na Fazenda Experimental Canguiri em Pinhais – PR. Foram 7 tratamentos testados para altura: Smart Measure (T1a), sMeasure (T2a), Distance meter (T3a), Hypsometer (T4a), 3D-Prumo (T5a), Height and Distance (T6a) e Tree-H (T7a). Foram 8 tratamentos para medir distância: Smart Measure (T1b), sMeasure (T2b), Distance meter (T3b), Hypsometer (T4b), 3D-Prumo (T5b), Height and Distance (T6b), Easy Measure (T7b) e Smart Distance (T8b). Avaliou-se a precisão dos aplicativos com o teste t de Student pareado com 5% de significância em relação às testemunhas e cálculo dos erros. Para altura em árvores isoladas, o tratamento T2a apresentou diferença estatística a probabilidade de 5%. O tratamento T6a obteve menor erro (2,48 m). No plantio de Eucalyptus sp., os tratamentos T1a, T6a e T7a apresentaram diferenças significativas e T3a obteve menor erro (2,99 m). Para a medição de distância em árvores isoladas, os tratamentos T4b e T6b não apresentaram diferença e T4b apresentou menor erro (2,28 m). No plantio, todos apresentaram diferença estatística. A incorporação de aplicativos para smartphones é alternativa para uso em inventários florestais para alturas. Para distâncias, deve-se ter cautela.
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Arty, Indyah Sulistyo. "SYNTHESIZE AND CITOTOXICITY TEST OF SEVERAL COMPOUNDS OF MONO PARA-HIDROXY CHALCON." Indonesian Journal of Chemistry 10, no. 1 (June 21, 2010): 110–15. http://dx.doi.org/10.22146/ijc.21489.

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Five compounds of mono para-hidroxy chalcon were synthesized (TC1, TC2, TC3, TC4, and TC5) and tested their cytotoxicity against HeLa cell and Raji cell. The difference in substituent of TC1 (R4 =H), TC2 (R4 = OCH3), and TC3 (R4 = F), showed the difference of their citotoxicity against HeLa cell. The citotoxicity of TC1 (LC50 = 16.08 µg/mL) ≈ TC3 (LC50 = 13.37 µg/mL), but the substituent difference of TC2 (LC50 = 147.43 µg/mL), decreasing it citotoxicity 10 times. Like wise their citotoxicity against Raji cell of TC1 (LC50 = 36.44 µg/mL) ≈ TC3 (LC50 = 30.46 µg/mL), but the substituent difference of TC2 (LC50 = 468.94 µg/mL), decreasing it citotoxicity activity 15 times. Nevertheless the strength of citotoxicity TC4 (LC50 = 98.74 µg/mL) and TC5 (LC50 = 110.97 µg/mL) against Raji cell are stronger than the citotoxicity of two of them against HeLa cell (LC50 of TC4 = none, LC50 of TC5 = 576.53 µg/mL). Keywords: mono para-hidroxy chalcon, HeLa cell, Raji cell, citotoxicity activity
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Uruilal, Costanza, Abraham Talahaturuson, Wihelmina Rumahlewang, and Jogeneis Patty. "ISOLASI Trichoderma spp. DAN DAYA ANTAGONISMENYA TERHADAP SCLEROTIUM ROLFSII SACC. PENYEBAB PENYAKIT LAYU PADA TANAMAN CABAI (Capsicum anuum) SECARA IN-VITRO." JURNAL BUDIDAYA PERTANIAN 13, no. 2 (December 1, 2017): 64–67. http://dx.doi.org/10.30598/jbdp.2017.13.2.64.

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The objective of this study is to isolation and agonistic test ability of Trichoderma spp. againts Sclerotium rolfsii Sacc. cause of wilting on pepper plants and has been conducted in Pathogenicity Laboratory Faculty of Agriculture Unpatti. The study use 5 treatment of isolate Trichoderma spp. (Tc3, Tc4, Tc5, Tc6 and Tc7) with 3 replications so that there are 15 experimental units. The results showed that the five isolates Trichoderma spp. has an antagonistic power to S. rolfsii with an average percentage of inhibition of S. rolfsii of 26,01%. Percentage of inhibition bolth of isolate ware not significantly different at 95% level test results between treatment. Average percentage inhibition of S. rolfsii by Trichoderma spp. each treatment was Tc6 = 27,31%, Tc3 = 26,63%, Tc5 = 26,05%, Tc7 = 25,69% and Tc4 = 24,37%. Keywords: antagonism, Trichoderma spp., Sclerotium rolfsii Abstrak Penelitian ini bertujuan mengisolasi dan menguji kemampuan antagonis Trichoderma spp. terhadap Sclerotium rolfsii Sacc. penyebab layu pada tanaman cabai dan telah dilaksanakan di Laboratorium Patogenisitas Fakultas Pertanian Unpatti, dengan menggunakan 5 perlakuan isolat Trichoderma spp. (Tc3, Tc4, Tc5, Tc6 dan Tc7) dengan 3 ulangan sehingga terdapat 15 satuan percobaan. Hasil penelitian menunjukkan bahwa kelima isolat Trichoderma sp. mempunyai daya antagonis terhadap S. rolfsii dengan rata-rata persentase penghambatan S. rolfsii sebesar 26%. Hasil analisis varians pada taraf 95% menunjukkan tidak ada perbedaan nyata antara perlakuan. Rata-rata persentase penghambatan S. rolfsii oleh Trichoderma spp. masing-masing perlakuan berturut-turut adalah Tc6 = 27,31%, Tc3 = 26,63%, Tc5 = 26,05%, Tc7 = 25,69% dan Tc4 = 24,37%, dengan rata-rata 26,01%. Kata kunci: antagonisme, Trichoderma spp., Sclerotium rolfsii
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Gibala, Martin J., Dave A. MacLean, Terry E. Graham, and Bengt Saltin. "Tricarboxylic acid cycle intermediate pool size and estimated cycle flux in human muscle during exercise." American Journal of Physiology-Endocrinology and Metabolism 275, no. 2 (August 1, 1998): E235—E242. http://dx.doi.org/10.1152/ajpendo.1998.275.2.e235.

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We examined the relationship between tricarboxylic acid (TCA) cycle intermediate (TCAI) pool size, TCA cycle flux (calculated from leg O2uptake), and pyruvate dehydrogenase activity (PDHa) in human skeletal muscle. Six males performed moderate leg extensor exercise for 10 min, followed immediately by intense exercise until exhaustion (3.8 ± 0.5 min). The sum of seven measured TCAI (ΣTCAI) increased ( P ≤ 0.05) from 1.39 ± 0.11 at rest to 2.88 ± 0.31 after 10 min and to 5.38 ± 0.31 mmol/kg dry wt at exhaustion. TCA cycle flux increased ∼70-fold during submaximal exercise and was ∼100-fold higher than rest at exhaustion. PDHa corresponded to 77 and 90% of TCA cycle flux during submaximal and maximal exercise, respectively. The present data demonstrate that a tremendous increase in TCA cycle flux can occur in skeletal muscle despite a relatively small change in TCAI pool size. It is suggested that the increase in ΣTCAI during exercise may primarily reflect an imbalance between the rate of pyruvate production and its rate of oxidation in the TCA cycle.
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Hohmann, Uwe, Winfried Busch, Katia Badaeva, Bernd Friebe, and Bikram S. Gill. "Molecular cytogenetic analysis of Agropyron chromatin specifying resistance to barley yellow dwarf virus in wheat." Genome 39, no. 2 (April 1, 1996): 336–47. http://dx.doi.org/10.1139/g96-044.

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Nine families of bread wheat (TC5, TC6, TC7, TC8, TC9, TC10, TC14, 5395-(243AA), and 5395) with resistance to barley yellow dwarf virus and containing putative translocations between wheat and a group 7 chromosome of Agropyron intermedium (L1 disomic addition line, 7Ai#1 chromosome) induced by homoeologous pairing or tissue culture were analyzed. C-banding, genomic in situ hybridization (GISH), and restriction fragment length polymorphism (RFLP) in combination with repetitive Agropyron-specific sequences and deletion mapping in wheat were used to determine the relative locations of the translocation breakpoints and the size of the transferred alien chromatin segments in hexaploid wheat–Agropyron translocation lines. All homoeologous compensating lines had complete 7Ai#1 or translocated 7Ai#1–7D chromosomes that substitute for chromosome 7D. Two complete 7Ai#1 (7D) substitution lines (5395-(243AA) and 5395), one T1BS–7Ai#1S∙7Ai#1L addition line (TC7), and two different translocation types, T7DS–7Ai#1S∙7Ai#1L (TC5, TC6, TC8, TC9, and TC10) and T7DS∙7DL–7Ai#1L (TC14), substituting for chromosome 7D were identified. The substitution line 5395-(243AA) had a reciprocal T1BS∙1BL–4BS/T1BL–4BS∙4BL translocation. TC14 has a 6G (6B) substitution. The RFLP data from deletion mapping studies in wheat using 37 group 7 clones provided 10 molecular tagged chromosome regions for homoeologous and syntenic group 7 wheat or Agropyron chromosomes. Together with GISH we identified three different sizes of the transferred Agropyron chromosome segments with approximate breakpoints at fraction length (FL) 0.33 in the short arm of chromosome T7DS–7Ai#1S∙7Ai#1L (TC5, TC6, TC8, TC9, and TC10) and another at FL 0.37 of the nonhomoeologous translocated chromosome T1BS–7Ai#1S∙7Ai#1L (TC7). One breakpoint was identified in the long arm of chromosome T7DS∙7DL–7Ai#1L (TC14) at FL 0.56. We detected some nonreciprocal translocations for the most proximal region of the chromosome arm of 7DL, which resulted in small duplications. Key words : C-banding, genomic in situ hybridization (GISH), physical mapping, translocation mapping, RFLP analysis.
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Constantin-Teodosiu, Dumitru, Elizabeth J. Simpson, and Paul L. Greenhaff. "The importance of pyruvate availability to PDC activation and anaplerosis in human skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism 276, no. 3 (March 1, 1999): E472—E478. http://dx.doi.org/10.1152/ajpendo.1999.276.3.e472.

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No studies have singularly investigated the relationship between pyruvate availability, pyruvate dehydrogenase complex (PDC) activation, and anaplerosis in skeletal muscle. This is surprising given the functional importance attributed to these processes in normal and disease states. We investigated the effects of changing pyruvate availability with dichloroacetate (DCA), epinephrine, and pyruvate infusions on PDC activation and accumulation of acetyl groups and tricarboxylic acid (TCA) cycle intermediates (TCAI) in human muscle. DCA increased resting PDC activity sixfold ( P < 0.05) but decreased the muscle TCAI pool (mmol/kg dry muscle) from 1.174 ± 0.042 to 0.747 ± 0.055 ( P < 0.05). This was probably a result of pyruvate being diverted to acetyl-CoA and acetylcarnitine after near-maximal activation of PDC by DCA. Conversely, neither epinephrine nor pyruvate activated PDC. However, both increased the TCAI pool (1.128 ± 0.076 to 1.614 ± 0.188, P < 0.05 and 1.098 ± 0.059 to 1.385 ± 0.114, P < 0.05, respectively) by providing a readily available pool of pyruvate for anaplerosis. These data support the hypothesis that TCAI pool expansion is principally a reflection of increased muscle pyruvate availability and, together with our previous work (J. A. Timmons, S. M. Poucher, D. Constantin-Teodosiu, V. Worrall, I. A. Macdonald, and P. L. Greenhaff. J. Clin. Invest. 97: 879–883, 1996), indicate that TCA cycle expansion may be of little functional significance to TCA cycle flux. It would appear therefore that the primary effect of DCA on oxidative ATP provision is to provide a readily available pool of acetyl groups to the TCA cycle at the onset of exercise rather than increasing TCA cycle flux by expanding the TCAI pool.
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Diamond, John M. "TCA Toxicity." Journal of the American Academy of Child & Adolescent Psychiatry 32, no. 6 (November 1993): 1307–8. http://dx.doi.org/10.1097/00004583-199311000-00031.

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Dick, William F., and Jason B. Hack. "TCA overdose." Annals of Emergency Medicine 33, no. 6 (June 1999): 723–24. http://dx.doi.org/10.1016/s0196-0644(99)80017-1.

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Migdał-Mikuli, Anna, and Elżbieta Szostak. "Phase Polymorphism of [Mn(DMSO)6](ClO4)2 Studied by Differential Scanning Calorimetry." Zeitschrift für Naturforschung A 60, no. 4 (April 1, 2005): 289–95. http://dx.doi.org/10.1515/zna-2005-0413.

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Abstract Six solid phases of [Mn(DMSO)6](ClO4)2 have been detected by differential scanning calorimetry. The phase transitions were found between the following solid phases: stable KIc ↔ stable KIb at TC5 = 225 K, metastable KIII ↔ metastable KII at TC4 = 322 K, stable KIb ↔ stable KIa at TC3 = 365 K, metastable KII↔overcooled K0 at TC2 = 376 K and stable KIa→stable K0 at TC1 = 379 K. The title compound melts at Tm = 488 K.
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Li, Sheng-You, Ze-Kun Sun, Xue-Yi Zeng, Yue Zhang, Meng-Ling Wang, Sheng-Cao Hu, Jun-Rong Song, et al. "Potent Cytotoxicity of Novel L-Shaped Ortho-Quinone Analogs through Inducing Apoptosis." Molecules 24, no. 22 (November 15, 2019): 4138. http://dx.doi.org/10.3390/molecules24224138.

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Twenty-seven L-shaped ortho-quinone analogs were designed and synthesized using a one pot double-radical synthetic strategy followed by removing methyl at C-3 of the furan ring and introducing a diverse side chain at C-2 of the furan ring. The synthetic derivatives were investigated for their cytotoxicity activities against human leukemia cells K562, prostate cancer cells PC3, and melanoma cells WM9. Compounds TB1, TB3, TB4, TB6, TC1, TC3, TC5, TC9, TC11, TC12, TC14, TC15, TC16, and TC17 exhibited a better broad-spectrum cytotoxicity on three cancer cells. TB7 and TC7 selectively displayed potent inhibitory activities on leukemia cells K562 and prostate cancer cells PC3, respectively. Further studies indicated that TB3, TC1, TC3, TC7, and TC17 could significantly induce the apoptosis of PC3 cells. TC1 and TC17 significantly induced apoptosis of K562 cells. TC1, TC11, and TC14 induced significant apoptosis of WM9 cells. The structure-activity relationships evaluation showed that removing methyl at C-3 of the furan ring and introducing diverse side chains at C-2 of the furan ring is an effective strategy for improving the anticancer activity of L-shaped ortho-quinone analogs.
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Dissertations / Theses on the topic "TCA"

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Bengtsson, Viktor, and Robert Ljungberg. "Beslutsmodell för outsourcing." Thesis, Tekniska Högskolan, Högskolan i Jönköping, JTH, Industriell organisation och produktion, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-24736.

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Syfte – Examensarbetets syfte är att skapa förståelse kring ett outsourcingbeslut genom att utveckla en beslutsmodell för outsourcing. För att uppnå syftet ska följande frågeställningar besvaras: Vilka faktorer bör påverka ett outsourcingbeslut? Vilka kostnader bör analyseras för att ett outsourcingbeslut ska bli väl avvägt? Vilka komponenter bör ingå i en beslutsmodell för outsourcing? Metod – Examensarbetet bygger på en analytisk konceptuell studie med ett deduktiv och induktiv förhållningssätt, där påverkansfaktorer togs fram genom litteraturstudier. Jämförelser och analyser av redan befintliga teorier gjordes för att identifiera påverkansfaktorer, utifrån dessa faktorer skapades en beslutsmodell för outsourcing. Resultat – Resultatet från studien visar att det finns ett flertal olika faktorer som påverkar ett outsourcingbeslut och kan sammanfattningsvis placeras som påverkansfaktorer, strategiska- och konkurrensfaktorer samt kostnadsfaktorer. Den utvecklade beslutsmodellen för outsourcing består av sju steg där varje steg innefattar olika analyser och beslut, de sju stegen baseras på de faktorer som bör påverkas vid outsourcing. Förslag till fortsatta studier – För att utveckla beslutsmodellen skulle fler teorier och faktorer som möjligen kan beröras i samband med outsourcing adderas. En ytterligare studie skulle kunna vara att utveckla ett verktyg där organisationen kan gradera hur organisationen förhåller sig till de faktorer som påverkas vid ett outsourcingbeslut och därmed utöka beslutsunderlaget. Praktiska konsekvenser – För att underlätta för beslutsfattaren och få en helhetsbild över faktorer och kostnader som påverkas vid outsourcing kan beslutsmodellen användas. Originalitet – Det finns enligt författarnas vetskap ingen fullständig beslutsmodell som belyser alla faktorer som kan påverkas vid ett outsourcingbeslut.
Purpose – The purpose of the thesis is to create understanding of the outsourcing decision making by developing a decision model for outsourcing. To achieve this, the following questions are answered: What factors should influence the outsourcing decision? What costs should be analyzed so that an outsourcing decision should be balanced? What components should be included in a decision model for outsourcing? Method – The thesis is based on an analytical conceptual study with a deductive and inductive approach, where the influencing factors was generated through literature reviews. Comparison and analysis of existing theories were made to identify the influencing factors, based on the generated influencing factors a decision model for outsourcing was created. Findings – Results from the study shows that there are several factors that influence the outsourcing decision and can in summary be positioned as strategic and competitive factors and cost factors. The developed decision model for outsourcing consists of seven steps, where each step includes various analyzes and decisions, the seven steps are based on the factors that should be affected by outsourcing. Research limitations/implications – The results in this thesis are based only on theory. The model can still be generalized by being adaptable for different Organization. Practical implications – Decision model can be used to aid and support in an outsourcing decision. To facilitate the decision-maker and get an overview of the factors and costs that are affected by the outsourcing decision model can be used. With the decision model, the organization can analyze factors and costs to obtain a comprehensive decision-making. Originality – Since many organizations are making outsourcing decision wrongly without taking into account all the factors affected by the outsourcing decision. There is, in the authors' knowledge no complete decision model that highlights all the factors that may be affected by an outsourcing decision.
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Sa, Wanderley Pires de. "Reconstrução do equilíbrio no tokamak TCA/BR." Universidade de São Paulo, 1996. http://www.teses.usp.br/teses/disponiveis/43/43131/tde-12122013-162240/.

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A determinação precisa e rápida das configurações de equilíbrio Magnetohidrodinâmico (MHD) em tokamaks é de fundamental importância para o confinamento magnético do plasma. Através do conhecimento dos parâmetros que caracterizam este equilíbrio MHD é possível controlar o plasma durante a sua formação por processos de realimentação. Uma análise mais detalhada destes parâmetros é necessária, também, entre um disparo e outro, para a estruturação do experimento. Neste trabalho é investigada a reconstrução das configurações de equilíbrio MHD no tokamak TCA/BR a partir de medidas magnéticas externas, utilizando um método que permite uma rápida determinação dos parâmetros principais da descarga. A tese divide-se em duas partes. Na primeira, é apresentada a construção de um código de equilíbrio que resolve a equação de Grad-Shafranov para a configuração geométrica que caracteriza o tokamak TCA/BR. Na segunda, é descrito o processo de reconstrução do equilíbrio MHD através de medidas de campos e fluxos magnéticos externos ao plasma no TCA/BR, e utilizando o método de Função de Parametrização FP. Este método baseia-se no tratamento estatístico de um banco de dados simulados de configurações de equilíbrio, com o objetivo de obter uma expressão simples relacionando os parâmetros que caracterizam o equilíbrio e as medidas realizadas. Os resultados obtidos através da FP são comparados com os obtidos através de outros métodos convencionais.
The accurate and rapid determination of the Magnetohydrodynamic (MHD) equilibrium configuration in tokamaks is a fundamental subject for the magnetic confinement of the plasma. With the knowledge of characteristic plasma MHD equilibrium parameters it is possible to control the plasma position during its formation using feed-back techniques. It is also necessary an on-line analysis between successive discharges to program external parameters for the subsequent discharges. In this work it is investigated the MHD equilibrium configuration reconstruction of the TCA/BR tokamak from external magnetic measurements, using a method that is able to determine fastly the main parameters of discharge. The thesis has two parts. Firstly it is presented the development of an equilibrium co de that solves de Grad-Shafranov equation for the TCA/BR tokamak geometry. Secondly it is presented the MHD equilibrium reconstruction process from external magnetic field and flux measurements using the Function Parametrization FP method. This method is based on the statistical analysis of a database of simulated equilibrium configurations, with the goal of obtaining a simple relationship between the parameters that characterize the equilibrium and the measurements. The results from FP are compared with conventional methods.
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Williams, Thomas C. R. "Metabolic Flux Analysis of the TCA Cycle in Arabidopsis." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515020.

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Duperrex, Pierre-André. "Measurement of magnetic fluctuations in the JET and TCA tokamak /." Lausanne : CRPP [Centre de recherches en physique des plasmas], Ecole polytechnique fédérale de Lausanne, 1988. http://library.epfl.ch/theses/?nr=715.

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Smith, Anna Marie Odette. "Investigating the TCA cycle in isolated plant mitochondria using NMR." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409761.

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Martin, Yves. "Injection de glaçons dans le tokamak TCA : étude du processus d'ablation /." Lausanne : CRPP, 1993. http://library.epfl.ch/theses/?nr=1045.

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Dhami, Neha. "Interference of central metabolism (TCA cycle) to influence CHO cell productivity." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/interference-of-central-metabolism-tca-cycle-to-influence-cho-cell-productivity(a0854462-66d2-498e-bf5e-2f651907572d).html.

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This PhD project explored the role of tricarboxylic acid (TCA) cycle enzymes in regulating Chinese hamster ovary (CHO) cell metabolism with respect to growth and recombinant protein expression. It was hypothesised that regulation of central metabolism can influence CHO cell productivity in terms of biomass and protein production. Thus the aim of these studies was to identify the key metabolic reactions of the TCA cycle associated with growth and protein expression in CHO cells. The gene expression of all TCA cycle genes was independently knocked-down using RNAi technology. The small interfering RNA (siRNA) mediated silencing of 11 TCA cycle genes significantly reduced cellular growth along with a decline in adenylate energy charges and an increase in catabolic reduction charges. The gene profiling of glucose and amino acid metabolism (not targeted by siRNA) suggested siRNA mediated knock-down of targeted TCA cycle genes led to cellular stress along with an enhanced rate of glycolysis leading to channelling of glucose for the generation of pyruvate. For the purpose of estimating intracellular metabolites, quenching and extraction method using ammonium bicarbonate and methanol was optimised to use with UCB CHO-K1 cell line and static transient siRNA transfections. A gas chromatography-mass spectrometry (GC-MS) analysis post-silencing of the aconitase gene, which catalyses the conversion of citrate to isocitrate in the TCA cycle, yielded higher MS peak intensities of at least four metabolites (gluconic acid, lysine, threonine and leucine) 72 h post-transfection in comparison to the controls. Transient knock-down of gene expression of seven TCA cycle genes in a recombinant stable cell line (expressing a rabbit monoclonal antibody) reduced cellular growth and altered the energy charges leading to a decline in antibody expression. Although silencing of the pyruvate dehydrogenase E1 gene, which is the component of the pyruvate dehydrogenase complex connecting glycolysis to the TCA cycle, did not affect cell viability, a reduction in antibody expression was recorded. Seven TCA cycle genes which demonstrated the most significant effect on cellular growth and energy charges were transiently over-expressed along with a monoclonal antibody in CHO-K1 cells with addition of their corresponding preceding intermediates. No differences in protein expression and cell specific productivity were observed compared to the control transfections. These results could be due to limitations of the effects of transient transfections for enhancing the metabolic activity of CHO cells. The aconitase gene demonstrated the most significant effect on CHO cell growth and proliferation in this study, therefore this gene was proposed as a novel selection marker for a metabolic selection system for the generation of recombinant therapeutics. This PhD project also established metabolite analysis tools and siRNA protocols for future metabolomic studies for investigating the intracellular CHO metabolism. The findings validated the hypothesis that TCA cycle plays an important role in CHO cell growth and recombinant protein production. The key metabolic genes affecting cellular growth and altering energy metabolism can be further explored for generation of an energy efficient CHO host-cell line (by over-expression of key TCA cycle genes) for enhanced recombinant protein production.
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Lima, Rosemilda Mendes. "POLÍTICAS CULTURAIS, DEMOCRATIZAÇÃO E ACESSO A CULTURA: O “DOMINGO NO TCA”." Instituto de Humanidades, Artes e Ciências Prof. Milton Santos, 2016. http://repositorio.ufba.br/ri/handle/ri/27351.

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A dissertação Políticas culturais, democratização e acesso a cultura: O Domingo no TCA tem como objeto de estudo o projeto Domingo no TCA, que visa uma maior democratização do acesso ao Teatro Castro Alves (TCA) e a sua programação. Criado em um contexto de mudanças nas políticas públicas federais e estaduais, o projeto é realizado há quase dez anos pelo TCA, maior teatro do estado, vinculado à Secretaria de Cultura (Secult) e à Fundação Cultural do Estado da Bahia (Funceb). O Domingo no TCA acontece na Sala Principal do TCA, que tem capacidade para 1.554 espectadores, com ingressos a preço simbólico de R$ 1,00 (inteira) e vem atraindo mensalmente, nas manhãs de domingo, um público numeroso e eclético, formado por adultos, crianças e idosos, oriundos dos mais diversos bairros de Salvador. De 2007 a 2015, foram realizadas 112 apresentações de 104 espetáculos de várias linguagens artísticas. A pesquisa para esta dissertação foi realizada utilizando-se dos registros do Sistema TCA, relatórios institucionais, pesquisas acadêmicas e entrevistas com os atores envolvidos, desde os principais gestores da Secult, aos artistas, produtores e público em geral. O objetivo foi analisar o projeto enquanto instrumento de políticas públicas de cultura e verificar a sua importância para cena e as políticas culturais baianas. A dissertação foi estruturada em três capítulos, de forma que, no primeiro momento, sejam abordados temas conceituais da área da cultura, passando depois ao estudo do Teatro Castro Alves em si e do projeto Domingo no TCA.
The dissertation Cultural policies, democratization and access to culture: Domingo no TCA has as object of study the Domingo no TCA (Sunday at TCA) project, which seeks to provide a greater democratization of access to the Castro Alves Theater (TCA) and its events. Created in a context of changes in federal and state public policies, the project is being carried out for almost ten years by the TCA, Bahia's largest theater, linked to the Secretariat of Culture (Secult) and the Bahia State Cultural Foundation (Funceb). The Domingo no TCA presentations take place at the theater's Main Hall, which can accommodate up to 1,554 spectators, with tickets costing a symbolic price of R$ 1.00 (full price). Monthly, on Sunday mornings, they have been attracting a large and eclectic audience consisting of adults, children and the elderly, from all kinds of neighborhoods of Salvador. From 2007 to 2015, there were 112 presentations of 104 different shows from several art forms. The research for this dissertation was carried out using the records of the TCA System, institutional reports, academic research and interviews with the people involved, from the main managers of Secult, to the artists, producers and the public in general. The objective was to analyze the project as an instrument of public policies of culture and to verify its importance for the cultural scene and policies of Bahia. The dissertation was structured in three chapters, such that in the first moment conceptual themes related to culture were approached, then going to the study of the Castro Alves Theater itself and the Domingo no TCA project.
La disertación Políticas culturales, democratización y acceso a la cultura: El Domingo en TCA tiene como objeto de estudio el proyecto Domingo no TCA (Domingo en TCA), que busca una mayor democratización del acceso al Teatro Castro Alves (TCA) y su programación. Creado en un contexto de cambios en las políticas públicas federales y estatales, el proyecto es realizado desde hace casi diez años por el TCA, el teatro más grande de Bahía, vinculado a la Secretaría de Cultura (Secult) y la Fundación Cultural del Estado de Bahía (Funceb). Las presentaciones del Domingo no TCA tienen lugar en la sala principal del teatro, que tiene capacidad para 1554 espectadores, con entradas a un precio simbólico de R$ 1,00 (precio entero), y vienen atrayendo mensualmente, en las mañanas de domingo, un público numeroso y ecléctico, formado por adultos, niños y ancianos, oriundos de los más diversos barrios de Salvador. De 2007 a 2015, se llevaron a cabo 112 presentaciones de 104 espectáculos de diversos lenguajes artísticos. La investigación para esta disertación se llevó a cabo utilizando los registros del Sistema TCA, informes institucionales, investigaciones académicas y entrevistas con las personas implicadas, desde los principales gestores de Secult, hasta los artistas, productores y el público en general. El objetivo fue analizar el proyecto como un instrumento de políticas públicas de cultura y verificar su importancia para la escena y las políticas culturales de Bahía. La disertación se estructuró en tres capítulos, de modo que en un primer momento sean abordados temas conceptuales de la cultura, pasando en seguida al estudio del propio Teatro Castro Alves y del proyecto Domingo no TCA.
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Meek, David J. J. "Molecular and genetic characterization of putative TCA cycle operons on Sinorhizobium meliloti." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33808.

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Genetic mapping of pDS15 revealed that this cosmid clone carries the Sinorhizobium meliloti TCA cycle genes mdh, sucCDAB, sdhAB and part of lpdA. Three genes (mdh, sucC , and sucA) were completely sequenced and submitted to GenBank. The nucleotide and amino acid sequences of the TCA cycle genes encoded on pDS15 were aligned and found to be highly homologous with other closely related rhizobial species. S. meliloti cells grown in LBmc express the mdh-sucCDAB operon as one transcript, based on RT-PCR results. Alternative sigma factor sigma54 was not found to have a role in mdh-sucCDAB expression. Despite considerable effort, we have not been able to isolate sucA mutants via random transposon Tn5tac1 mutagenesis to date. Homologous recombination between a plasmid-borne sucA::Tn5 and wild-type S. meliloti sucA failed to generate a bona fide mutant, as revealed by Southern blot analysis. Plasmid pDS15 was mutagenized with transposons Tn5, Tn5tac1, and Tn5-B20. Three Tn5-B20 insertions were mapped to mdh, sucD, and sucA respectively, and preliminary gene expression studies were done.
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Meek, David John. "The biochemical and genetic characterization of the TCA cycle in «Sinorhizobium meliloti»." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121142.

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In the symbiotic association between S. meliloti and its plant host, the nutrient exchange from plant to bacteroid is in the form of C4-dicarboxylic acids such as malate. These compounds directly enter the TCA cycle and the derived energy is used for the nitrogen-fixation process. Malate dehydrogenase (mdh), the two subunits of succinyl-CoA synthetase (sucCD), and two of the three subunits of 2-oxoglutarate dehydrogenase (sucAB) are encoded as an operon with the order mdh-sucCDAB. The expression of this operon is controlled by a single promoter found directly upstream of mdh. The transcrptional start site was mapped (a guanine residue at postion -63) and RT-PCR demonstrated that expression is as one polycistronic message in cells grown in LBmc. Transcriptional lacZ-gene fusions to mdh, sucD and sucA demonstrated that the mdh promoter is under catabolite control as evidenced by the change in ß-galactosidase expression depending on the carbon-source. Expression was highest with acetate followed closely by arabinose and glutamate but lowest with pyruvate as sole carbon-source. MDH was purified, N-terminal sequenced and kinetic assays were performed to determine Km, Vmax. A pH 10 was found to be the optimal for MDH. 2-oxoglutarate exhibited competitive inhibition on MDH. The annotated genome of S. meliloti contains two alleles (sucB), one chromosomal and one on megaplasmid pSymB, which putatively encode the E2 subunit of 2-oxoglutarate dehydrogenase. Only the chromosomally-borne allele was found to be a functional sucB. Lastly, results of a study of the E3 subunits of pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and branched-chained keto-acid dehydrogenase were presented.
Dans la relation symbiotique entre S. meliloti et la plante M. sativa, l'apport en nutriments de la plante vers les bacteroids se fait sous la forme d'acides C4-dicarboxiliques tel que le malate. Ces composés entrent directement dans le cycle de Krebs et l'énergie produite est utilisée pour la fixation d'azote. Malate déhydrogénase (mdh), les deux composantes de succinyl-CoA synthèse (sucCD), et deux des trois composantes de 2-oxoglutarate déhydrogénase (sucAB), sont inscrites en un opéron dans l'ordre qui suit ; mdh-sucCDAB. L'expression de cet opéron est contrôlée par un seul promoteur situé directement en amont de mdh. Le site de début de transcription a été identifié et RT-PCR a démontré la nature polycistronique de l'expression dans les cellules provenant de bactéries cultivées avec LBmc. Fusions transcriptionelles aux gene-lacZ de mdh, sucD et sucA ont été utilisées pour déterminer les niveaux relatifs d'expression dans des cultures provenant de médiums minimaux contenant des sources de carbone spécifiques. MDH a été purifié, le N-terminal séquencé, et des dosages cinétiques ont été performés pour déterminer Km, Vmax, le pH optimal, et l'effet des inhibiteurs allostériques. Le génome annoté de S. meliloti contient deux allèles qui encodent supposément les composantes E2 (sucB) de 2-oxoglutarate déhydrogénase. Un seul des allèles a démontré être une version fonctionnelle de sucB. Finalement, les résultats d'une étude sur les composantes E3 de pyruvate déhydrogénase, sur 2-oxoglutarate déhydrogénase et sur déhydrogénase de kéto-acide de chaines ramifiées seront présentés.
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Books on the topic "TCA"

1

Workers, Canadian Auto. CAW TCA Canada. Toronto: CAW TCA Canada, 2000.

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Star, Philip. Bod yno: Adnoddau ar gyfer hanes TCA. Caerdydd: Gwasg APCC, 2001.

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Accreditation, TESOL Commission on, ed. The TCA standards for intensive English programs. Alexandria, PA: TESOL Commission on Accreditation, 1998.

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Njokou, Dieudonné. TCA camerounaise: Mieux connaître pour mieux la gérer. Yaoundé: Editeur Ets TWT, 1994.

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J, Mendlewicz, and Lecrubier Yves, eds. Antidepressant selection: Proceedings from a TCA/SSRI consensus conference. Copenhagen, Denmark: Munksgaard, 2000.

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J, Mendlewicz, and Lecrubier Yves, eds. Antidepressant selection: Proceedings from a TCA/SSRI consensus conference. Copenhagen, Denmark: Munksgaard, 2000.

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Bull, Richard J. Mechanisms of carcinogenesis by dichloroacetate (DCA) and trichloroacetate (TCA). Denver, Colo: American Water Works, 1999.

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Laszuk, Andrzej. Wymiana ciepła w aparacie z trójfazowym złożem fluidalnym typu TCA. Kraków: Politechnika Krakowska im. Tadeusza Kościuszki, 1989.

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Mackenzie, Carrie. TCA cycle enzymes and aluminum - citrate metabolism in Pseudomonas fluorescens. Sudbury, Ont: Laurentian University, 2001.

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Litvin, F. L. Topology of modified helical gears and tooth contact analysis (TCA) program. Cleveland, Ohio: Lewis Research Center, 1989.

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Book chapters on the topic "TCA"

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Cramer, Christopher J. "Fifty years of TCA." In Perspectives on Theoretical Chemistry, 1–6. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28445-8_1.

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Bandel, Tobias, Jan Köpper, Laura Mervelskemper, Christopher Bonnet, and Arno Scheepens. "The Business of TCA." In True Cost Accounting for Food, 209–20. New York : Routledge, 2021. | Series: Routledge studies in food, society and the environment: Routledge, 2021. http://dx.doi.org/10.4324/9781003050803-14.

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Grimes, Pearl E. "Combination Salicylic Acid/TCA Chemical Peeling." In Color Atlas of Chemical Peels, 103–10. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/3-540-30223-9_10.

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Faoro, Valentina, and Giorgio Stanta. "Trichloroacetic Acid (TCA) Precipitation of Proteins." In Guidelines for Molecular Analysis in Archive Tissues, 257–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-17890-0_40.

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Grimes, Pearl E. "Combination Salicylic Acid/TCA Chemical Peeling." In Color Atlas of Chemical Peels, 63–69. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-20270-4_8.

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Ranimol, G., C. B. Devipriya, and Swetha Sunkar. "Docking and Molecular Dynamics Simulation Studies for the Evaluation of Laccase Mediated Biodegradation of Triclosan." In Proceedings of the Conference BioSangam 2022: Emerging Trends in Biotechnology (BIOSANGAM 2022), 205–13. Dordrecht: Atlantis Press International BV, 2022. http://dx.doi.org/10.2991/978-94-6463-020-6_20.

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AbstractTriclosan (TCA) is an antibacterial and antimicrobial compound that is incorporated into toothpaste, soap, and liquid dishwasher. Continuous TCA exposure may contribute to the emergence of antibiotic-resistant bacteria in the microbiome. Triclosan also reacts to form dioxins, which bioaccumulate and are toxic to aquatic organisms, impedes the thyroid hormone metabolism of the human body. Laccases are multi copper-containing enzymes that can degrade the aromatic compounds and thus reduce their toxicity. To effectively degrade the compound, it is essential to understand the molecular function of the enzyme. Hence, a molecular docking study of laccase enzymes with Triclosan was done. The Tramates versicolor laccase structure was retrieved from PDB and ligand structure was taken from Pubchem. The binding mode and interaction of TCA and laccase were studied using Auto dock Vina software and the stability of the docked complex had been explored via Molecular Dynamics (MD) simulation study using Schrodinger Desmonde. The binding affinity score was found to be −6.5kcal/mol. The majority of the residues in RMSF were within the 2.5Å limit. The radius of gyration remained within the range from 21.7 to 22.1Å for Laccase – TCA complex throughout the 50 ns simulation. MD simulation results show that the enzyme complex remains stable all through the catalytic action.
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Obagi, Zein E. "Overview of TCA and Other Chemical Peels." In Obagi Skin Health Restoration and Rejuvenation, 111–26. New York, NY: Springer New York, 2000. http://dx.doi.org/10.1007/978-0-387-21801-4_7.

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Merrigan, Kathleen A. "Embedding TCA Within US Regulatory Decision-Making." In True Cost Accounting for Food, 179–88. New York : Routledge, 2021. | Series: Routledge studies in food, society and the environment: Routledge, 2021. http://dx.doi.org/10.4324/9781003050803-12.

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van Leeuwen, A., F. P. M. J. van Bree, A. Termijtelen, J. J. van Rood, R. Willemze, W. Fibbe, and A. A. Biegel. "TCA and MLCs in Bone Marrow Transplant Patients." In Immunobiology of HLA, 510–11. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-662-39946-0_219.

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Piva, Terrence J., and Edward McEvoy-Bowe. "The Truncated TCA Cycle in HeLa Cell Mitochondria." In Advances in Experimental Medicine and Biology, 385–91. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3404-4_43.

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Conference papers on the topic "TCA"

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"PV-055 - TRASTORNO BIPOLAR Y TRASTORNO POR CONSUMO DE SUSTANCIAS COMÓRBIDO: UN ANÁLISIS DE MACHINE-LEARNING." In 24 CONGRESO DE LA SOCIEDAD ESPAÑOLA DE PATOLOGÍA DUAL. SEPD, 2022. http://dx.doi.org/10.17579/abstractbooksepd2022.pv055.

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Descripción precisa de los objetivos: El trastorno por consumo de sustancias (TCS) es una comorbilidad común en individuos con trastorno bipolar (TB) y se asocia a una peor evolución clínica del TB. El presente estudio tiene como objetivo adoptar un algoritmo de machine-learning para identificar qué características sociodemográficas o clínicas están más asociadas a la presencia de diferentes tipos de TCS en el TB. Material y métodos: Pacientes adultos con TB fueron reclutados en la Unidad de Trastornos Bipolares y Depresivos del Hospital Clínic de Barcelona. Se recogieron las características sociodemográficas y clínicas y se entrenaron cuatro Random Forests (RFs) para predecir la presencia de TCS en general, de trastorno por consumo de alcohol (TCA), o de TCA y al menos otro tipo de TCS (TCA+TCS) en la muestra total o en diferentes submuestras. Las variables más importantes seleccionadas por los RFs se consideraron como variables independientes en regresiones logísticas múltiples para predecir la presencia de TCSs. Resultados y conclusiones: Se incluieron a un total de 508 pacientes (276 mujeres) con TB-I (345) o TB-II (205); entre ellos 262 presentaron comorbilidad con TCS (108 con solo TCA, 106 con TCA+TCS). El TCS se predijo con una precisión del 65,3%, y se asoció con un comórbido trastorno de la personalidad de cluster B (OR=2,31; p=0,006) y tener una relación (OR=0,6; p=0,015). El TCA+TCS (precisión=75%) se asoció con un primer episodio hipomaniaco (OR=4,34; p=0,01), y hetero-agresividad (OR=3,15; p=0,003). El TCA+TCS en una submuestra que incluía solo a personas con TCA (precisión=62.5%) se asoció con un primer episodio afectivo depresivo (OR=0,41; p=0,011). Ninguna variable se asoció con el TCA (precisión=53.8%). Incluir sólo los factores sociodemográficos y clínicos en modelos de machine-learning limita su eficacia, y los futuros modelos deberían considerar también predictores biológicos, clínicos y de neuroimagen para explorar más esta asociación.
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Duan, Shitong, Lingyun Zhong, and Feng Lin. "Simplified-TCA: A Simplified TCA Algorithm for Charging Scenarios." In 2021 4th International Conference on Advanced Electronic Materials, Computers and Software Engineering (AEMCSE). IEEE, 2021. http://dx.doi.org/10.1109/aemcse51986.2021.00093.

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"TCA Y ALCOHOL, DIFERENTES MECANISMOS PARA SILENCIAR EL DOLOR. A PROPÓSITO DE UN CASO." In 23° Congreso de la Sociedad Española de Patología Dual (SEPD) 2021. SEPD, 2021. http://dx.doi.org/10.17579/sepd2021p045v.

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OBJETIVOS: Demostrar la relación que existe entre el alcohol y el TCA. MATERIAL Y METODOS: Revisión sistemática y exposición de un caso clínico. RESULTADOS : Desde hace décadas se han realizado investigaciones en la línea de buscar una comorbilidad entre los TCA y el consumo de sustancias. Según la evidencia científica se ha demostrado que existe una elevada prevalencia de abuso de sustancias entre pacientes con TCA, mucho más acentuada con el alcoholismo. La bulimia nerviosa es la enfermedad en la que se han descrito mayor número de trastornos por abuso de sustancias, siendo la prevalencia en torno al 2,6 mayor que en anoréxicas purgativas y a su vez que en las restrictivas. Por otro lado, se ha encontrado que el 35-40% de alcohólicos tienen historia de TCA. Se ha establecido como factor común en ambas patologías el déficit en la regulación del control de impulsos y el afecto. Así como una elevada prevalencia de antecedentes familiares de alcoholismo (73,3%) y antecedentes de malos tratos (43,3%), que podría indicar que estas pacientes presentan una marcada vulnerabilidad para el desarrollo de alcoholismo y cierto grado de indefensión. CONCLUSIONES:Se ha observado que el TCA aparece previo a la dependencia alcohólica en un 86,6% de los casos, mayoritariamente en la adolescencia, con mayor frecuencia de conductas de atracones y purgativas. Describiéndose además la utilización del alcohol con fin anorexígeno, lo que nos sugiere que el alcohol cumpliría una función dentro del TCA y que a su vez una abstinencia mantenida durante 6 m se asociaría a una buena evolución de aproximadamente el 50% de los TCA. El abordaje precoz del riesgo de dependencia alcohólica en pacientes diagnosticadas de TCA disminuiría la comorbilidad de ambos trastornos y mejoraría el TCA. Esto supondría beneficio clínico para el paciente y la disminución de costes sociosanitarios.
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"O-048 - TCA Y TUS, PROPUESTA DE UN MODELO DE TRATAMIENTO INTEGRADOR." In 24 CONGRESO DE LA SOCIEDAD ESPAÑOLA DE PATOLOGÍA DUAL. SEPD, 2022. http://dx.doi.org/10.17579/abstractbooksepd2022.o048.

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INTRODUCCION Y OBJETIVOS A pesar de la alta tasa de trastornos alimentarios (TCA) y trastornos por uso de sustancias (TUS) concurrentes en las mujeres, existe una falta de tratamiento integrado. Los trastornos por uso de sustancias (TUS) y los trastornos de conducta alimentaria (TCA) ocurren con frecuencia en mujeres. Las opciones de tratamiento para esta población siguen siendo limitadas. A menudo ambos trastornos son abordados secuencialmente, abordando primero el trastorno más grave, o de manera simultánea, pero en programas separados. Los TCA y TUS concurrentes se asocian con recaídas frecuentes y malos resultados del tratamiento. Las investigaciones llevadas a cabo sobre programas de tratamiento integrados son escasas. El objetivo de este trabajo es revisar la situación actual respecto de los programas de tratamiento ya existentes, para personas con TCA y TUS concurrentes. así como una propuesta de tratamiento por parte de la UTCA Santa Cristina. MATERIAL Y METODOS Para la elaboración de este trabajo se ha realizado una exhaustiva revisión bibliográfica de más de 30 artículos de carácter científico, tanto de revisión como experimentales pertenecientes al subtipo de ensayos clínicos acerca de los programas integrados de tratamiento para TCA y TUS existentes hasta la actualidad a través de los buscadores Pub Med y Google académico. Desde la UTCA del HU Santa Cristina llevamos a cabo un programa de tratamiento en aquellas pacientes con TCA y TUS lo más integrador posible en dos vertientes. Se expondrán los tipos de intervenciones y la adaptación del tratamiento, integrador, a este perfil de pacientes. CONCLUSIONES Las mujeres con TCA y TUS concurrentes que ingresan al tratamiento de la UTCA son una población especial donde el TUS a menudo recibe un tratamiento insuficiente. Abordar el uso de sustancias dentro del contexto del tratamiento del TCA puede derribar barreras actuales, demostrando su eficacia para esta población.
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"PS-042 - MARCO TEÓRICO DE APROXIMACIÓN DE TRASTORNOS ADICTIVOS Y TRASTORNOS DE LA CONDUCTA ALIMENTARIA." In 24 CONGRESO DE LA SOCIEDAD ESPAÑOLA DE PATOLOGÍA DUAL. SEPD, 2022. http://dx.doi.org/10.17579/abstractbooksepd2022.ps042.

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Objetivos La relación clínica entre trastornos adictivos (TA) y trastornos de la conducta alimentaria (TCA) tuvo un fundamental apoyo con los criterios diagnósticos de Goodman, que permitieron clasificar conductas de estirpe impulsiva como son el juego, la compra compulsiva y, posteriormente (finales de los noventa) bulimia nerviosa y anorexia nerviosa. Si bien las semejanzas sintomatológicas son destacadas por los clínicos que trabajan en ambos grupos, es preciso realizar una comparativa entre características fisiopatológicas, anatomoestructurales, bioquímicas y genéticas para alcanzar el objetivo del presente trabajo, desarrollar un marco teórico de similitud entre TA y TCA, que pudiese acercar maniobras terapéuticas en ambos grupos de patologías. Métodos Se realiza una revisión narrativa con los últimos hallazgos característicos de patologías TA y TCA, a nivel fisiopatológico, estructural (neuroimagen) y molecular (bioquímico y genético), expuestos a modo de espejo, para una mayor clarificación. Resultados y conclusiones En los estudios de neuroimagen en las adicciones, así como en las investigaciones neuropsicológicas, además del sistema dopaminérgico, se presta especial atención a algunas regiones del cerebro que han surgido repetidamente en dichos estudios. Las regiones más consistentemente implicadas son partes de la corteza frontal (corteza orbitofrontal y corteza prefrontal dorsolateral), el cíngulo rostral, la amígdala y la ínsula. Los estudios de análisis GWAS ha conseguido relacionar TCA y TA de manera específica, no en su conjunto, lo que ha permitido inferir la diferencia incluso entre los propios TCA, desde un punto de vista genético. Desde un punto de vista bioquímico, los niveles anómalos de receptores dopaminérgicos D2 en circuitos de recompensa entre trastornos por atracón y adicción por sustancias, acerca los grupos de TCA y TA, pero diferencia también de manera intragrupal las enfermedades. La dificultad para tratar de manera farmacológica los TCA, podría verse mitigada si se consiguiese establecer una correlación entre ambos grupos de enfermedades.
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"PV-122 - TRASTORNO DE LA CONDUCTA ALIMENTARIA Y TRASTONO POR CONSUMO DE ANFETAMINAS. A PRÓPOSITO DE UN CASO." In 24 CONGRESO DE LA SOCIEDAD ESPAÑOLA DE PATOLOGÍA DUAL. SEPD, 2022. http://dx.doi.org/10.17579/abstractbooksepd2022.pv122.

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INTRODUCCION: La asociación entre los trastornos de conducta alimentaria (TCA) y los trastornos por uso de sustancias (TUS) pueden complicar el tratamiento y pronóstico de ambas patologías, siendo esta una comorbilidad frecuente. El efecto anorexígeno de la anfetamina puede relacionarse con el desarrollo de un TCA. CASO CLINICO: Presentamos el caso clínico de una mujer de 20 años, con diagnóstico en la adolescencia de TDAH y tratamiento con derivados anfetamínicos en aquel momento, que ha desarrollado un TCA tipo bulimia nerviosa, por el cual se encuentra en la unidad de tratamiento intensivo de TCA (UTCA). En la actualidad mantiene consumo de diversas sustancias que puedan alterar el apetito, siendo los derivados anfetamínicos los más utilizados por ella para este fin. Presenta rasgos de personalidad obsesivos y dependientes, e ideas devaluadoras permanentes sobre sí misma. DISCUSION: El carácter anorexigénico de los derivados anfetamínicos parece jugar un papel relevante a la hora de elegir su consumo, que puede llegar a ser buscado en mercados ilegales, en pacientes con vulnerabilidad para desarrollar un TCA. Ambos trastornos tendrían una influencia bidireccional, dificultando una buena evolución de la paciente, si no se tratan a la par. CONCLUSION: Siempre será necesario explorar un posible trastorno por uso de sustancias en pacientes con sintomatología alimentaria o diagnóstico de TCA. Además se recomienda, siempre que sea posible, evitar el uso de fármacos con características anorexigénicas en pacientes con perfil diana para el desarrollo de un trastorno de la conducta alimentaria, clásicamente, mujeres jóvenes de áreas urbanas.
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González Soriano, Patricia, Mª Luisa Fernández Rocha, Antonio Villas Palau, Juana María Pérez Gómez, and Manuel Benítez Zamorano. "Prevalencia de Trastornos por Uso de Sustancias en pacientes con Trastorno de la Conducta Alimentaria: Una revisión sistemática." In 22° Congreso de la Sociedad Española de Patología Dual (SEPD) 2020. SEPD, 2020. http://dx.doi.org/10.17579/sepd2020p087.

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INTRODUCCIÓN Y OBJETIVOS Los Trastornos de la Conducta Alimentaria (TCA) son trastornos mentales que se caracterizan por un comportamiento patológico frente a la ingesta alimentaria y el control del peso. Se ha observado que los TCA y los Trastornos por Uso de Sustancias (TUS) aparecen relacionados en muchas ocasiones e influyen en la mortalidad y morbilidad de estos. El objetivo principal de este trabajo es conocer la evidencia existente sobre la relación entre los TUS y los subtipos de TCA. METODOLOGÍA Se ha efectuado una búsqueda bibliográfica en la base de datos Pubmed, utilizando como palabras clave "eating disorder", "drug abuse", "substance use disorder", restringiendo la búsqueda a artículos en inglés, en los últimos 15 años y que contengan estas palabras clave en el título o abstract. RESULTADOS Y CONCLUSIONES Hay estudios que evidencian la concordancia entre los TUS y los diferentes tipos de TCA, observándose una mayor comorbilidad en los pacientes con bulimia o trastornos por atracón, que en los diagnosticados de anorexia nerviosa de tipo restrictivo. Estos trastornos tienen una relación directa con comportamientos impulsivos y buscan el alivio a los problemas de ansiedad, depresión y otros subyacentes. Por otra parte, se ha catalogado un nuevo trastorno alimentario, la "drunkorexia", que es común en la adolescencia y que se caracteriza por una restricción de comida en los días que se planea un consumo excesivo de alcohol, para no renunciar al consumo del mismo y, de esta forma, evitar un aumento de peso. Como conclusión, los TCA se asocian de forma significativa con los TUS. Es importante reconocer el abuso de alcohol y otras drogas en pacientes con TCA para facilitar su seguimiento y recuperación, monitorizándolos y desarrollando un tratamiento multidisciplinar, individualizado y adaptado a las diferentes patologías coexistentes.
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"PS-007 - PATOLOGÍA DUAL Y TCA. PROYECTO PLANTEADO A PROPÓSITO DE DOS CASOS." In 24 CONGRESO DE LA SOCIEDAD ESPAÑOLA DE PATOLOGÍA DUAL. SEPD, 2022. http://dx.doi.org/10.17579/abstractbooksepd2022.ps007.

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-Objetivos: en los últimos años, las prevalencias del trastorno por uso de sustancias (TUS) y trastorno de la conducta alimentaria (TCA) han aumentado notablemente. Previamente ya se había descrito la co-existencia de TUS en pacientes con TCA, incluso el hecho de que el TCA preceda al TUS en un número importante de casos. Existen dudas interesantes en cuanto al perfil de paciente que puede presentar mayor riesgo de desarrollar dicha combinación TUS+TCA. Se plantea la posibilidad de que la adicción a la restricción alimentaria , presente tanto en casos de anorexia (AN) como bulimia (BN), como otros, pudiera jugar un papel en determinar el riesgo de que un individuo con TCA pueda desarrollar un TUS. A raíz de dos casos clínicos (AN y BN) en los que se detectó consumo de tóxicos relevante y gran componente restrictivo, se plantea el objetivo de estudiar dicha relación mediante el método de estudio que se expone. - Material y métodos: se realizó búsqueda bibliográfica extensa en diversas bases de datos para determinar bibliografía existente y realizar un diseño preliminar del estudio. - Resultados: se plantea el diseño de un estudio transversal pensado para aplicar en población en seguimiento en Salud Mental con diagnóstico de TCA. Consiste en la recopilación de datos sociobiográficos generales y la aplicación de cuestionarios validados sobre consumo de tóxicos junto con el cuestionario Valencia de restricción alimentaria para valorar el papel que pueda jugar dicha restricción (entendida como adicción comportamental) en el desarrollo de un TUS. En los dos casos que motivaron el estudio, se obtuvieron puntajes altos de dependencia a alcohol y benzodiacepinas, así como una puntuación muy elevada en el Cuestionario Valencia, mostrando cualitativamente asociación entre restricción y TUS a pesar de los diferentes diagnósitcos. Este hallazgo puede indicar una asociación que debe ser investigada más exhaustivamente.
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"PS-002 - TRASTORNO DE LA CONDUCTA ALIMENTARIA Y TRASTORNO POR USO DE ALCOHOL." In 24 CONGRESO DE LA SOCIEDAD ESPAÑOLA DE PATOLOGÍA DUAL. SEPD, 2022. http://dx.doi.org/10.17579/abstractbooksepd2022.ps002.

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1. Objetivos: Existe evidencia científica de que las mujeres con TCA presentan significativamente mayor prevalencia de Trastorno por Uso de Alcohol en comparación con la población general. En la práctica clínica habitual se realiza abordaje terapéutico de un caso de TCA con debut durante la pandemia que, transcurridos unos meses, inicia consumo abusivo de alcohol que posteriormente alcanza patrón de dependencia. Los objetivos del presente trabajo son los de conocer las singularidades de ambos trastornos cuando coexisten. 2. Material y métodos: Informe del caso y realización de una revisión no sistemática en las principales bases de datos. 3. Resultados: La asociación entre ambos trastornos se manifiesta más en las pacientes que presentan conductas de tipo purgativo y atracones que en las que presentan conductas meramente restrictivas. Se ha reportado una mayor incidencia de inicio de TCA antes del inicio de Trastorno por Uso de Alcohol. Las pacientes con TCA que posteriormente debutan con Trastorno por Uso de Alcohol presentan puntuaciones más elevadas de búsqueda de nuevas sensaciones y impulsividad, en comparación con las que no desarrollan un Trastorno por Uso de Alcohol. Se ha demostrado que los factores genéticos pueden influenciar en la comorbilidad. A niveles más elevados de purgas y atracones, frecuencias más altas de consumo de otras sustancias. Los niveles más altos de atracones de comida no se asocian con la frecuencia de consumo de alcohol pero sí con el patrón binge de consumo. Las otras sustancias más consumidas por las pacientes son las sedativas como benzodiacepinas o marihuana. Conclusiones: Debemos considerar el aumento del riesgo de Trastorno por Uso de Alcohol en pacientes TCA, así como la posible aparición de clínica TCA en pacientes con Trastorno por Uso de Alcohol. La coexistencia de ambos trastornos dificulta la evaluación, el tratamiento y los resultados de la intervención.
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Yuasa, Takayuki, Tadayuki Takahashi, Masaharu Nomachi, and Makoto Ioki. "Scalable SpaceWire backplane system using µTCA." In 2012 IEEE-NPSS Real Time Conference (RT 2012). IEEE, 2012. http://dx.doi.org/10.1109/rtc.2012.6418177.

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Reports on the topic "TCA"

1

Muss, Jeffrey. 5Klbf Unielement TCA for Film Cooling Model Validation. Fort Belvoir, VA: Defense Technical Information Center, April 2003. http://dx.doi.org/10.21236/ada414443.

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Hall, George F., Benjamin R. Partin, and John H. Storm. Large Frame Aircraft (LFA) Fire Fighting Validation. TCA/PCA Methodology Evaluation. Fort Belvoir, VA: Defense Technical Information Center, January 1995. http://dx.doi.org/10.21236/ada300680.

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Streso, Katy, and Francesco Lagona. Hidden Markov random field and FRAME modelling for TCA-image analysis. Rostock: Max Planck Institute for Demographic Research, October 2005. http://dx.doi.org/10.4054/mpidr-wp-2005-032.

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Qian, David. The Role of Mitochondrial TCA Cycle Enzymes in Determining Prostate Cancer Chemosensitivity. Fort Belvoir, VA: Defense Technical Information Center, March 2014. http://dx.doi.org/10.21236/ada605984.

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Qian, David. The Role of Mitochondrial TCA Cycle Enzymes in Determining Prostate Cancer Chemosensitivity. Fort Belvoir, VA: Defense Technical Information Center, March 2012. http://dx.doi.org/10.21236/ada564586.

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Qian, David. The Role of Mitochondrial TCA Cycle Enzymes in Determining Prostate Cancer Chemosensitivity. Fort Belvoir, VA: Defense Technical Information Center, March 2013. http://dx.doi.org/10.21236/ada581651.

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Qian, David. The Role of Mitochondrial TCA Cycle Enzymes in Determining Prostate Cancer Chemosensitivity. Fort Belvoir, VA: Defense Technical Information Center, March 2011. http://dx.doi.org/10.21236/ada543825.

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Pixley, Charles E. The Strategic Use of the US Army Veterinary Service in HCA/TCA Operations. Fort Belvoir, VA: Defense Technical Information Center, April 1997. http://dx.doi.org/10.21236/ada326668.

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Hua, D. D., R. J. Donahue, C. M. Celata, and E. Greenspan. Monte Carlo simulations of neutron well-logging in granite and sand to detect water and trichloroethane (TCA). Office of Scientific and Technical Information (OSTI), January 1998. http://dx.doi.org/10.2172/650225.

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Figueredo, Luisa, Liliana Martinez, and Joao Paulo Almeida. Current role of Endoscopic Endonasal Approach for Craniopharyngiomas. A 10-year Systematic review and Meta-Analysis Comparison with the Open Transcranial Approach. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2023. http://dx.doi.org/10.37766/inplasy2023.1.0045.

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Review question / Objective: To identify and review studies published in the last ten years, presenting the efficacy and outcomes of EEA and TCA for patients with cranio-pharyngiomas. Eligibility criteria: Studies meeting the following criteria were included: (a) retrospective and prospective studies and (b) observational studies (i.e., cross-sectional, case-control, case-series). The outcomes included visual outcomes (improvement, no changes, worsening), endocrinological outcomes (permanent diabetes insipidus and hypopituitarism), operatory site infection, meningitis, cerebrospinal fluid leak, stroke, hemorrhage, and mortality. Studies were excluded if they were determined to be: (a) case-report studies, (b) studies testing genetic disorders, (c) poster presentation abstracts without full-text availability, (d) systematic reviews, and (e) metanalyses.
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