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Relevant bibliographies by topics / TAU58

Academic literature on the topic 'TAU58'

Author: Grafiati

Published: 10 December 2022

Last updated: 29 January 2023

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Journal articles on the topic "TAU58"

1

Przybyla, Magdalena, Janet van Eersel, Annika van Hummel, Julia van der Hoven, Miheer Sabale, Anne Harasta, Julius Müller, et al. "Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature." Brain 143, no. 6 (May 6, 2020): 1889–904. http://dx.doi.org/10.1093/brain/awaa133.

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Abstract Hyperphosphorylation and deposition of tau in the brain characterizes frontotemporal dementia and Alzheimer’s disease. Disease-associated mutations in the tau-encoding MAPT gene have enabled the generation of transgenic mouse models that recapitulate aspects of human neurodegenerative diseases, including tau hyperphosphorylation and neurofibrillary tangle formation. Here, we characterized the effects of transgenic P301S mutant human tau expression on neuronal network function in the murine hippocampus. Onset of progressive spatial learning deficits in P301S tau transgenic TAU58/2 mice were paralleled by long-term potentiation deficits and neuronal network aberrations during electrophysiological and EEG recordings. Gene-expression profiling just prior to onset of apparent deficits in TAU58/2 mice revealed a signature of immediate early genes that is consistent with neuronal network hypersynchronicity. We found that the increased immediate early gene activity was confined to neurons harbouring tau pathology, providing a cellular link between aberrant tau and network dysfunction. Taken together, our data suggest that tau pathology drives neuronal network dysfunction through hyperexcitation of individual, pathology-harbouring neurons, thereby contributing to memory deficits.

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2

Kreilaus, Fabian, Rebecca Masanetz, Georgia Watt, Magdalena Przybyla, Arne Ittner, Lars Ittner, and Tim Karl. "The behavioural phenotype of 14-month-old female TAU58/2 transgenic mice." Behavioural Brain Research 397 (January 2021): 112943. http://dx.doi.org/10.1016/j.bbr.2020.112943.

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3

Van Erum, Jan, Femke Valkenburg, Debby Van Dam, and Peter Paul De Deyn. "Pentylenetetrazole-induced Seizure Susceptibility in the Tau58/4 Transgenic Mouse Model of Tauopathy." Neuroscience 425 (January 2020): 112–22. http://dx.doi.org/10.1016/j.neuroscience.2019.11.007.

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4

Kreilaus, Fabian, Magdalena Przybyla, Lars Ittner, and Tim Karl. "Cannabidiol (CBD) treatment improves spatial memory in 14-month-old female TAU58/2 transgenic mice." Behavioural Brain Research 425 (May 2022): 113812. http://dx.doi.org/10.1016/j.bbr.2022.113812.

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5

Valkenburg, Femke, Debby Van Dam, Yannick Vermeiren, Tony Aerts, and Peter Paul De Deyn. "MONOAMINERGIC CORRELATES OF DISINHIBITED BEHAVIOURS IN THE NOVEL TAU58/4 TRANSGENIC MOUSE MODEL FOR TAUOPATHY." Alzheimer's & Dementia 13, no. 7 (July 2017): P1486. http://dx.doi.org/10.1016/j.jalz.2017.07.565.

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6

Watt, Georgia, Rose Chesworth, Magdalena Przybyla, Arne Ittner, Brett Garner, Lars M. Ittner, and Tim Karl. "Chronic cannabidiol (CBD) treatment did not exhibit beneficial effects in 4-month-old male TAU58/2 transgenic mice." Pharmacology Biochemistry and Behavior 196 (September 2020): 172970. http://dx.doi.org/10.1016/j.pbb.2020.172970.

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7

Heltsley, Brian K. "Experimental summary on hadronic decays: A TAU98 review." Nuclear Physics B - Proceedings Supplements 76, no. 1-3 (April 1999): 391–400. http://dx.doi.org/10.1016/s0920-5632(99)00497-1.

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8

Al-Nakkash, Layla, Daniel Mason, Niamatullah Ismail, Taylor Bowman, John Ahlert, Maxwell Rubin, Emma Smith, Abigail Rosander, and Tom L. Broderick. "Exercise Training Prevents the Loss of Wall Thickness and Lowers Expression of Alzheimer’s Related Proteins in 3xTg Mouse Jejunum." International Journal of Environmental Research and Public Health 19, no. 21 (October 29, 2022): 14164. http://dx.doi.org/10.3390/ijerph192114164.

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Growing evidence has demonstrated the benefits of regular exercise on cardiovascular, neural, and cognitive function in humans with Alzheimer’s disease (AD). However, the consequences of AD on gastrointestinal morphology and the effects of regular exercise, which plays an important role against the development of certain gastrointestinal-related diseases, are still poorly understood. Therefore, to assess the changes in intestinal structure in a mouse model of AD and the impact of exercise, 2-month-old 3xTg-AD male mice were subjected to treadmill running 5 days per week for a period of 5 months. Jejunum from 3xTg-AD mice analyzed by histochemical methods revealed significant alterations in morphology. Compared to age-matched wild-type (WT) mice, villi length and crypt depth were increased, and collagen content of jejunum was elevated in 3xTg-AD mice. Jejunum wall dimensions, expressed as total wall thickness, outer longitudinal thickness, and inner circular thickness were decreased in 3xTg-AD compared to WT. Smooth muscle actin expression in jejunal wall was decreased in 3xTg-AD. Most of these aberrations were improved with exercise. Western blot expression of cyclin dependent kinase 5 (CDK5, involved in neural cell death and hyperphosphorylation of tau), was elevated in 3xTg-AD jejunum. This was associated with a 4-fold increase in tau5 expression. Exercise prevented the increase in expression of CDK5 and tau5. Expression of caspase 3 (an apoptotic marker) was elevated in 3xTg-AD jejunum and exercise prevented this. The results of our study indicate that the abnormalities in jejunum of the 3xTg mouse model of AD were prevented with exercise training.

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9

González, Andrea, Leonardo Guzmán-Martínez, and Ricardo B. Maccioni. "Plasma Tau Variants Detected by a Novel Anti-Tau Monoclonal Antibody: A Potential Biomarker for Alzheimer’s Disease." Journal of Alzheimer's Disease 77, no. 2 (September 15, 2020): 877–83. http://dx.doi.org/10.3233/jad-200386.

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Background: A major drawback in Alzheimer’s disease (AD) is the lack of validated biomarkers for routine clinical diagnostic. We have reported earlier a novel blood biomarker, named Alz-tau®, based on variants of platelet tau. This marker evaluates the ratio of high molecular weight tau (HMWtau) and the low molecular weight (LMWtau) tau. Objective: To analyze a potential novel source of antigen for Alz-tau®, plasma tau, detected by immunoreactivity with the novel monoclonal antibody, tau51. Methods: We evaluated tau variants in plasma precipitated with ammonium sulfate from 36 AD patients and 15 control subjects by western blot with this novel monoclonal antibody. Results: The HMW/LMWtau ratio was statistically different between AD patients and controls. Conclusions: Plasma tau variants are suitable to be considered as a novel antigen source for the Alz-tau® biomarker for AD.

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10

Bohrer, Laura R., Ping Liu, Jian Zhong, Yunqian Pan, James Angstman, Lucas J. Brand, Scott M. Dehm, and Haojie Huang. "FOXO1 binds to the TAU5 motif and inhibits constitutively active androgen receptor splice variants." Prostate 73, no. 10 (February 6, 2013): 1017–27. http://dx.doi.org/10.1002/pros.22649.

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