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Ekaputri, Putu Ayuwidia. "FDG PET and MRI as biomarkers of Tau pathology in Alzheimer’s disease." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20060.
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Fluorodeoxyglucose Positron Emission Tomography (FDG PET) and Magnetic Resonance Imaging (MRI) are commonly used in a clinical setting as an examination in Alzheimer’s Disease (AD) patients. FDG PET is an imaging tool to evaluate hypometabolism; meanwhile, the MRI observes the brain volume. However, it is still unclear which examination better reflects the tau tangles, which have been known as the hallmark’s pathology of AD. Therefore, this study was conducted to compare FDG PET and MRI in assessing tau pathology in AD, by utilizing a database from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). The presence of tau tangles was confirmed by using the Tau-PET images. In total, 275 cognitively impaired subjects were included as well as a subgroup of 147 subjects with positive amyloid status. Based on the analysis, it was observed that higher Tau-PET is significantly associated with FDG PET hypometabolism and MRI atrophy. A similar result was also seen in the amyloid positive subgroups. By comparing the spearman’s correlation coefficients, it was found that that the correlation was stronger between Tau PET and FDG PET (r=-0.414, p<0.001, and r=-0.475, p<0.001 in the positive amyloid subgroup) compared to Tau-PET and MRI (r=-0.331, p<0.001 and r=-0.440, p<0.001 in the positive amyloid subgroup). Inconclusion, FDG PET better reflects the tau pathology compared to MRI in AD.
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Chen, Siu-ping Chlore, and 陳少萍. "Noah's Ark housing for pet-lovers and SPCA." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31983224.
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Kinstedt, Christine Morgan. "The Development of PET Imaging Agents for Neurodegenerative Disorders." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1590834972520388.
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Jensen, Jordan Royce. "Development of Tau-Selective Imaging Agents for Improved Diagnosis of Alzheimer’s Disease and Other Tauopathies." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306441097.
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Dhaynaut, Maëva. "PET imaging for the characterization of tauopathies : Alzheimer's disease and chronic traumatic encephalopathy." Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS197.
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Les tauopathies sont des maladies neurodégénératives caractérisées par une agrégation intracérébrale de protéines Tau anormales. Au cours de ce travail doctoral, nous avons étudié par tomographie par émission de positons (TEP) l'imagerie des agrégats Tau dans la maladie d'Alzheimer (MA) et l'encéphalopathie traumatique chronique (ETC). Notre premier objectif était de déterminer la capacité de l’imagerie Tau-TEP à améliorer le diagnostic de la MA et de déterminer la viabilité d’un nouveau traitement potentiel. Nous avons établi que l'imagerie Tau-TEP était capable de détecter l'effet bénéfique d'une stimulation cérébrale non invasive, appelée stimulation transcrânienne à courant alternatif (tACS) chez les personnes atteintes de MA. Notre deuxième objectif était de déterminer l'utilité de l'imagerie Tau in vivo dans une population de joueurs de football américains pour aider à la détection précoce de l’ETC. Nous avons démontré que l’imagerie Tau était en mesure de mettre en évidence les premières étapes de la maladie. En outre, nous avons étudié par autoradiographie post-mortem chez des patients diagnostiqués MA et ETC, le schéma de liaison de [18F]-AV-1451 avec [18F]-MK-6240 et [18F]-PI-2620 dans les mêmes échantillons. Ces trois traceurs ont montré un modèle similaire de forte liaison à la protéine Tau dans la MA et un manque de liaison dans le cas de l’ETC. Au total, ces expériences ont permis de confirmer l'utilité potentielle de l’imagerie Tau-TEP pour la détection, quantification des agrégats de Tau avec le suivi de la progression de la maladie dans la MA, tout en restant incertain pour l’ETCTauopathies are neurodegenerative diseases characterized by intracerebral aggregation of abnormal Tau proteins. During this university thesis, we studied by Positon Emission Tomography (PET) imaging the Tau burden in Alzheimer’s Disease (AD) and Chronic Traumatic Encephalopathy (CTE), two different taupotahies with similar Tau isoforms. In this context, our first objective was to determine the ability of Tau PET imaging to improve the diagnosis of AD and to determine the viability of a new potential treatment. We have established that Tau PET imaging was able to detect the beneficial effect of a non-invasive brain stimulation, called transcranial alternating current stimulation (tACS) in people with AD. Our second objective was to determine the usefulness of Tau PET imaging in vivo in a population of American football players to help the early detection of CTE. We have demonstrated that in our population, Tau PET imaging was able to highlight the Tau pathology in early stages of CTE. In parallel, we have studied by autoradiography post-mortem from patients with neuro-pathological diagnosis of AD and CTE the binding pattern of three radiotracers widely used in research for Tau imaging. We directly compared the binding properties of [18F]-AV-1451 with [18F]-MK-6240 and [18F]-PI-2620 in the same specimens. These three tracers showed similar strong binding pattern to Tau protein in AD and a lack of binding in CTE brain slices. In total, these experiments allow to confirm the potential utility of Tau PET tracers for the reliable detection, quantification of Tau aggregates and disease-progression tracking in AD, while it remains questionable for CTE
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Degerman, Gunnarsson Malin. "Biomarkers as Monitors of Drug Effect, Diagnostic Tools and Predictors of Deterioration Rate in Alzheimer’s Disease." Doctoral thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-196965.
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Decreased amyloid-ß42 (Aß42), increased total tau (t-tau) and phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) reflect histopathological core changes in the most common dementia disorder, Alzheimer’s disease (AD). They discriminate AD from healthy controls and predict conversion to AD with a relatively high accuracy. Memantine, an uncompetitive NMDA-receptor antagonist, is indicated for symptomatic treatment of AD. The first aim of this thesis was to investigate effects of memantine on CSF concentrations of Aβ42, tau and p-tau. Secondly, the aim was to explore the relation between these CSF biomarkers and retention of the amyloid biomarker Pittsburgh compound B using positron emission tomography (PIB PET), regional glucose metabolism measured with 18Fluoro-2-deoxy-d-glucose (FDG) PET and neuropsychological test performance. The third aim was to investigate their possible utility as predictors of future rate of AD dementia deterioration. All patients in the studies were recruited from the Memory Clinic, Uppsala University Hospital. In study I CSF p-tau concentrations in 11 AD patients were reduced after twelve months treatment with memantine, indicating that this compound may affect a key pathological process in AD. Results from study II showed that the concentrations of CSF Aß42 are lower in PIB+ patients than in PIB- patients, and that the PIB retention was stable during 12 months. In study III 10 patients with the diagnoses AD (6 PIB+/4 PIB-) and 8 subjects (1 PIB+/7 PIB-) with frontotemporal dementia were included. PIB+ patients had lower psychomotor speed measured by performance on the Trail Making Test A and impaired visual episodic memory compared to the PIB- patients. The initial clinical diagnoses were changed in 33% of the patients (6/18) during follow-up. Study IV is the first-ever report of an association between high CSF tau and dying in severe dementia. These 196 AD patients were followed up to nine years after baseline lumbar puncture. Moreover, CSF t-tau concentrations above median was associated with an increased risk of rapid cognitive decline (OR 3.31 (95% CI 1.53-7.16), independently of baseline functional stage. Thus, a clear association between high levels of CSF t-tau and p-tau and a more aggressive course of the disease was shown.
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Cope, Thomas Edmund. "The physiology of dementia : network reorganisation in progressive non-fluent aphasia as a model of neurodegeneration." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275884.
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The dementias are persistent or progressive disorders affecting more than one cognitive domain that interfere with an individual’s ability to function at work or home, and represent a decline from a previous level of function. In this thesis I consider the neurophysiology of dementia at a number of levels. I investigate the ways in which the connectivity and function of the brain predisposes to the specific focal patterns of neurodegeneration seen in the various dementias. I aim to identify the mesoscopic changes that occur in individuals with neurodegeneration and how these relate to their cognitive difficulties. I show how, by assessing patients in whom there is focal disruption of brain networks and observing the outcomes in comparison to controls, I can gain insight into the mechanisms by which the normal brain makes predictions and processes language. In Chapter 1, I set the scene for the focussed experimental investigations of model diseases by beginning with an introductory, clinically-focussed review that sets out the features, aetiology, management, epidemiology and prognosis of the dementias. This places these model diseases in the context of the broader clinical challenge posed by the dementias. In Chapter 2, I turn to ‘prototypical’ model diseases that represent neurodegenerative tauopathies with predominantly cortical (Alzheimer’s disease, AD) and subcortical (Progressive Supranuclear Palsy, PSP) disease burdens. I investigate the neurophysiological causes and consequences of Tau accumulation by combining graph theoretical analyses of resting state functional MR imaging and in vivo ‘Tau’ PET imaging using the ligand AV-1451. By relating Tau distribution to the functional connectome I provide in vivo evidence consistent with ‘prion-like’ trans-neuronal spread of Tau in AD but not PSP. This provides important validation of disease modification strategies that aim to halt or slow down the progression of AD by sequestration of pathological Tau in the synapse. In contrast, I demonstrate associations consistent with regional vulnerability to Tau accumulation due to metabolic demand and a lack of trophic support in PSP but not AD. With a cross-sectional approach, using Tau burden as a surrogate marker of disease severity, I then go on to show how the changes in functional connectivity that occur as disease progresses account for the contrasting cognitive phenotypes in AD and PSP. In advancing AD, functional connectivity across the whole brain becomes increasingly random and disorganised, accounting for symptomatology across multiple cognitive domains. In advancing PSP, by contrast, disrupted cortico-subcortical and cortico-brainstem interactions meant that information transfer passed through a larger number of cortical nodes, reducing closeness centrality and eigenvector centrality, while increasing weighted degree, clustering, betweenness centrality and local efficiency. Together, this resulted in increasingly modular processing with inter-network communication taking less direct paths, accounting for the bradyphrenia characteristic of the ‘subcortical dementias’. From chapter 3 onwards, I turn to the in-depth study of a model disease called non-fluent variant Primary Progressive Aphasia (nfvPPA). This disease has a clear clinical phenotype of speech apraxia and agrammatism, associated with a focal pattern of mild atrophy in frontal lobes. Importantly, general cognition is usually well preserved until late disease. In chapter 3 itself, I relate an experiment in which patients with nfvPPA and matched controls performed a receptive language task while having their brain activity recorded with magnetoencephalography. I manipulated expectations and sensory detail to explore the role of top-down frontal contributions to predictive processes in speech perception. I demonstrate that frontal neurodegeneration led to inflexible and excessively precise predictions, and that fronto-temporal interactions play a causal role in reconciling prior predictions with degraded sensory signals. The discussion here concentrates on the insights provided by neurodegenerative disease into the normal function of the brain in processing language. Overall, I demonstrate that higher level frontal mechanisms for cognitive and behavioural flexibility make a critical functional contribution to the hierarchical generative models underlying speech perception In chapter 4, I precisely define the sequence processing and statistical learning abilities of patients with nfvPPA in comparison to patients with non-fluent aphasia due to stroke and neurological controls. I do this by exposing participants to a novel, mixed-complexity artificial grammar designed to assess processing of increasingly complex sequencing relationships, and then assessing the degree of implicit rule learning. I demonstrate that agrammatic aphasics of two different aetiologies are not disproportionately impaired on complex sequencing relationships, and that the learning of phonological and non-linguistic sequences occurs independently in health and disease. In chapter 5, I summarise the synergies between the experimental chapters, and explain how I have applied a systems identification framework to a diverse set of experimental methods, with the common goal of defining the physiology of dementia. I then return to the results of chapter 3 with a clinical focus to explain how inflexible predictions can account for subjective speech comprehension difficulties, auditory processing abnormalities and (in synthesis with chapter 4) receptive agrammatism in nfvPPA. Overall, this body of work has contributed to knowledge in several ways. It has achieved its tripartite aims by: 1) Providing in vivo evidence consistent with theoretical models of trans-neuronal Tau spread (chapter 2), and a comprehensive clinical account of the previously poorly-understood receptive symptomatology of nfvPPA (chapter 5), thus demonstrating that systems neuroscience can provide a translational bridge between the molecular biology of dementia and clinical trials of therapies and medications. In this way, I begin to disentangle the network-level causes of neurodegeneration from its consequences. 2) Providing evidence for a causal role for fronto-temporal interactions in language processing (chapter 3), and demonstrating domain separation of statistical learning between linguistic and non-linguistic sequences (chapter 4), thus demonstrating that studies of patients with neurodegenerative disease can further our understanding of normative brain function. 3) Successfully integrating neuropsychology, behavioural psychophysics, functional MRI, structural MRI, magnetoencephalography and computational modelling to provide comprehensive research training, as the platform for a future research programme in the physiology of dementia.
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Cisek, Katryna. "Rational Optimization of Small Molecules for Alzheimer’s Disease Premortem Diagnosis." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338325484.
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Ramon, Melanie Elaine. "The effects of demographics and pet ownership on attachment towards and opinion about owned and unowned free-roaming cats." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1021.
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Lundén, Amanda. "Can Sterol Carrie Protein-2 function as a solubility tag in E.coli?" Thesis, Linköpings universitet, Biologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-129803.
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Expressing foreign proteins in E.coli is a major challenge because they often tend to develop into unsolvable and inactive proteins. They aggregate into so called inclusion bodies which prevent expression of the protein. This problem might be avoided by fusing the gene of the foreign protein with a soluble protein called solubility tags, which function is to enhance the solubility of the foreign protein. This report investigates whether Sterol Carrier Protein-2 (SCP-2) could function as a solubility tag. The experiment was carried out by fusing SCP-2 to two recombinant proteins, Green fluorescent protein (GFP) and a form of chloroamphenicol acetyl transferase (CATΔ9). The gene fusion was then inserted into a pET-15 vector and transformed into the E.coli strain BL21(DE3) to be expressed. The results obtained from Western blot and PageBlue staining indicates that SCP-2 does not enhance the solubility of GFP or CATΔ9 since neither of them was expressed. Furthermore, previous studies have shown that GFP can in fact be expressed usingmaltose binding protein (MBP) as a solubility tag. Unfortunately, no success has been made regarding CATΔ9. In conclusion, regarding the results from this report, SCP-2 does not function as a solubility tag. However, further studies should be carried out on SCP-2 with more experiments before rejecting the possibility to use SCP-2 as a solubility tag.
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Griffiths, Neil. "Coronal and transition region structure in the RS CVn binaries V711 Tau, AR Lac and II Peg." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320278.
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Magnusson, Evelina, Mattias Klang, and Moa Westlund. "PET-bottles: From waste to resource." Thesis, KTH, Skolan för industriell teknik och management (ITM), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-264432.
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One of the biggest problems in Guatemala is the handling of plastic waste. Many of the watercourses and rivers in Guatemala are filled with plastic bottles which has a negative impact on both nature and the country’s inhabitants. At the same time, Guatemala is dealing with the problem of segregation between rich and poor. More than half of the population live under the poverty line and in bad conditions. Houses created by thin walls and aluminium roofs are common. In an earlier project an attempt to tackle part of these two issues has been developed by creating roofs our of plastic bottles. The project has been successful but also has some room for improvements. In this report these areas of improvements are investigated and analyzed by building a roof for a structure of 9 square meters. This project has a focus on improving the production process and product in order to make them comparable with the aluminium roofing sheets most commonly used today. With tests of possible external impacts that the roof likely will have to withstand, the solidity of the roof has been determined at the same time that evaluation of the process for one person has been compared with building a roof out of aluminium. Since aluminium is expensive and difficult to repair, the roof made out of plastic waste could be good alternative. However it may need an industrial process in order to make it cost and time effective. The production of a roof covering a building of nine square meters need 600 bottles and 41 hours of work.Ett av Guatemalas största problem är avfallshantering. Många av Guatemalas vattendrag är fyllda av plastflaskor och annat avfall vilket har en negativ påverkan på både naturen och landets befolkning. Samtidigt har Guatemala stora problem med segregation mellan fattiga och rika. Mer än hälften av befolkningen lever under fattigdomsgränsen och i dåliga förhållanden. I städer hör det inte till ovantligheten att se hus som enbart består av lätta väggar med en aluminiumplåt som tak. I ett tidigare projekt har dessa två problem försökts sammanfogas och lösas genom en process där PET-flaskor omformas till takbrickor. Projektet har varit framgångsrikt men har ett flertal förbättringsområden. I denna rapport har dessa förbattringsområden undersökts och analyserats genom att bygga ett tak för en struktur vars bas är 9 kvadratmeter. Detta projekt har fokus på att utveckla en process och en produkt som är jämförbara med de aluminiumtak som används idag. I form av tester på de möjliga påfrestningar tak utsätts för i Guatemala har kvaliten hos taken bedömts samtidigt som processen har beprövats och jämförts med processen för en privatperson att konstruera ett aluminiumtak. Då alumniumtak är dyrt och svårt att reparera kan plasttaken vara ett alternativ. Dock kan det krävas en industrialisering av processen för att det ska vara kostnads och tidseffektivt. Produktionen av ett plasttak på en byggnad som är nio kvadratmeter kräver 600 plastflaskor och 41 timmars arbete.
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Ghetti, Gabriele. "Localizzazione di tag passivi non lineari." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14276/.
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In questo lavoro di tesi è stato realizzato un software di elaborazione dei segnali ricevuti da una etichetta (tag) RFID chipless con l’obiettivo di stimare la distanza del tag rispetto alla posizione dei ricevitori. Questo progetto trova importanti applicazioni legate alla localizzazione sia in ambito hi-tech che di largo consumo, come ad esempio la logistica, l’automotive e i sistemi di automazione.
In questo progetto è stato curato specificamente il processo di acquisizione ed elaborazione dati, processando al calcolatore con l’ausilio del software MATLAB® i risultati provenienti da un simulatore circuitale del tag.
In particolare, i dati da elaborare sono stati forniti da un progetto di ricerca correlato a questo dove è stato studiato e realizzato un tag RFID chipless passivo di tipo armonico non lineare.
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Fantuzzi, Marco. "Progetto elettromagnetico di antenne per tag eco-compatibili a banda ultra-larga." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amslaurea.unibo.it/5969/.
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Questo lavoro si è occupato della ricerca e progettazione di un'antenna UWB per la realizzazione di un tag RFID e si colloca all'interno del progetto GRETA (GREen TAgs), finanziato dal MIUR.
Le principali caratteristiche richieste al green tag sono: dimensioni complessive di massimo 4-5 cm, assenza di batterie e compatibilità con l'ambiente. L'eco-compatibilità viene garantita tramite la realizzazione dell'antenna al di sopra di un substrato di carta; i limiti derivanti dall'assenza di batterie vengono invece sopperiti tramite realizzazione di energy harvesting, al fine di raggiungere una completa autonomia energetica. Viene sfruttata la tecnica UWB per la comunicazione nella banda (3.1-4.8 GHz); l'energy harvesting si effettua invece a 868 MHz. Sono infine stati ricavati alcuni primi risultati relativi alla potenza rettificabile con la soluzione proposta, tramite realizzazione di un opportuno circuito rettificatore.
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Gentile, Alessandro. "Progetto di un sistema di collaudo per un tag RFID uwb integrato." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9624/.
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La tesi è incentrata sul progetto di un PCB in grado di testare il corretto funzionamento del chip GRETA, un integrato dedicato, che implementa un nodo intelligente basato su harvesting RF. L'integrato implementa un sistema innovativo di comunicazione per RFID, che sfrutta la metodologia Green Tagging, per la trasmissione di sequenze RF. Vengono elaborate le diverse fasi di progettazione e di design pcb attraverso un programma di cad. Lo scopo è quello di realizzare un unico sistema perfettamente controllabile dall'utente, che attraverso i componenti messi a disposizione dalla scheda di testing, permetta di ricevere, inviare o escludere i segnali che afferiscono ai pin di Input/output del chip integrato. E' stata introdotta la possibilità di pilotare/testare separatamente le sottoparti interne al chip, con lo scopo di isolare eventuali malfunzionamenti.
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Berti, Federico. "RFID tag localization with virtual multi-antenna systems." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/9753/.
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In questa tesi si sono valutate le prestazioni di un sistema di localizzazione multi-antenna di tag radio frequency identification (RFID) passivi in ambiente indoor. Il sistema, composto da un reader in movimento che percorre una traiettoria nota, ha come obiettivo localizzare il tag attraverso misure di fase; più precisamente la differenza di fase tra il segnale di interrogazione, emesso dal reader, e il segnale ricevuto riflesso dal tag che è correlato alla distanza tra di essi.
Dopo avere eseguito una ricerca sullo stato dell’arte di queste tecniche e aver derivato il criterio maximum likelihood (ML) del sistema si è proceduto a valutarne le prestazioni e come eventuali fattori agissero sul risultato di localizzazione attraverso simulazioni Matlab.
Come ultimo passo si è proceduto a effettuare una campagna di misure, testando il sistema in un ambiente reale. Si sono confrontati i risultati di localizzazione di tutti gli algoritmi proposti quando il reader si muove su una traiettoria rettilinea e su una traiettoria angolare, cercando di capire come migliorare i risultati.
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Galagedara, Nelomie Nayanathara. "Identification of Quantitative Trait Loci for Resistance to Tan Spot in Durum Wheat." Thesis, North Dakota State University, 2018. https://hdl.handle.net/10365/28765.
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Tan spot, caused by Pyrenophora tritici-repentis (Ptr), is a major foliar disease on wheat. The pathosystem involves three pairs of necrotrophic effector (NE) and host sensitivity (S) gene interactions, namely Ptr ToxA-Tsn1, Ptr ToxB-Tsc2 and Ptr ToxC-Tsc1. Additionally, genetic factors conferring race-nonspecific resistance have been identified. The objectives of this study were to map tan spot resistance QTL and investigate the role of NE-S interactions in disease in durum using association and bi-parental mapping. Evaluation of a worldwide collection of durum accessions allowed identifying highly resistant nineteen lines to multiple Ptr races. Association mapping revealed genomic regions on chromosomes 1A, 2B and 3B significantly associated with resistance to tan spot, which likely correspond to Tsc1, Tsc2 and racenonspecific resistance. Using a bi-parental population derived from Ben and PI 41025, we found that ToxA-Tsn1 interaction plays no significant role in disease, instead a major race-nonspecific QTL on chromosome 5A was identified.
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Mitri, Giulia. "Progettazione Data Layer per un sistema di Tag Management finalizzato all’analisi dei dati." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2018.
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Questa tesi è il risultato del lavoro e dello studio effettuato all’interno dell’azienda che mi ha ospitata per il tirocinio.
Il Team nel quale sono stata inserita si occupa di progettare e implementare il Data Layer e i tag per la gestione del tracciamento dati, tramite i quali poi verranno svolte analisi per personalizzare sempre di più l’esperienza dell’utente all’interno del sito o dell’applicazione e per migliorarne le funzionalità.
Da tempo le aziende sono alla ricerca di un modello più semplice, flessibile, scalabile e standardizzato per rendere disponibili i dati alle soluzioni di Digital Analytics. Per sopperire a questa esigenza è stato creato il Data Layer. Il Data Layer consiste in un elemento logico che ha lo scopo di esporre i dati in appositi oggetti, che di per sé non hanno logica applicativa, ma che fungono da semplici contenitori di variabili e dati, affinchè questi possano essere poi letti ed utilizzati dalle altre piattaforme, tipicamente mediante soluzioni di tagging dinamico. Le soluzioni di tagging dinamico, collocate come livello logico intermedio tra il Data Layer e le piattaforme di Digital Analytics, forniscono la capacità di leggere dati dal Data Layer, di aggregarli con le sintassi e le logiche peculiari di ogni singola soluzione e di inviarli formattati nel modo corretto alle soluzioni di Digital Analytics.
Questa tesi è volta a descrivere il progetto nel quale sono stata inserita all'interno dell’azienda. L’oggetto principale di questo progetto consiste nella progettazione del Data Layer per l’implementazione di un sistema di Tag Management con lo scopo di effettuare il tracciamento dati relativo all’applicazione.
Il progetto in questione tratta di un’applicazione mobile di tipo finanziario disponibile solo sulla piattaforma iOS. Nello specifico è stata presa in analisi la parte di onboarding dell’applicazione. Per onboarding si intende la parte relativa alla registrazione e all’apertura di un conto corrente online.
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Kurdadze, Tamara, and Jurgita Simaityte. "The Effect of Per-Unit Ethanol Tax on Wine Prices : A Comparative Perspective: Sweden and Germany." Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, IHH, Nationalekonomi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-28388.
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After Swedish alcohol retail monopoly, Systembolaget, changed the taxation for alcohol sold in retail stores according to its absolute alcohol content in 1992, Ponicki et al. (1997) used this opportunity to examine the effect of per-unit alcohol tax on the prices of spirits, comparing before and after, and found that beverages from higher price range experienced a relatively smaller rise in price in percentage terms than the beverages from lower price range, which can be described as compression of prices. This paper builds on the statement and findings by Ponicki et al. in 1997 and looks at whether or not unit taxes on ethanol content, as opposed to ad valorem taxes, compress the price range and make low quality wines relatively more expensive after-tax in Sweden as compared to no alcohol-content taxation. For the purposes of comparison German wine market is selected due to its market specifics (no per-unit taxes on wine), geographical proximity and availability of wide range data. The perception that the Swedish Pigouvi-an alcohol content tax should make wines in low price ranges relatively more expensive than its pre-tax price and in high ranges relatively cheaper (Kronstam, B.-G., 2010) did not receive thorough support in this paper.
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Serafini, Marco. "Progetto di un tag RFID attivo in materiale tessile per sistemi di localizzazione indoor." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/18717/.
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In questo lavoro, si è voluto andare ad esplorare un’area nella quale sono presenti ancora ampi margini di miglioramento: la localizzazione indoor con l’utilizzo di tag RFID attivi e indossabili su tessuto e con la presenza di un singolo reader.
Decisa la tipologia di antenna e substrato si è andati a progettarle, grazie anche all’uso del software di simulazione elettromagnetica CST Microwave Studio.
Le antenne proposte sono tre patch con substrato in Denim di diverso spessore: queste sono state progettate e realizzate.
Finita la fase di realizzazione, le antenne sono state caratterizzate: inizialmente, di ognuna di esse, ne abbiamo calcolato guadagno, return loss (S11) e il diagramma di radiazione.
Il lavoro svolto da questo punto in avanti si è basato esclusivamente sulla localizzazione e sul capire come sfruttare al meglio quanto fatto fino a questo momento, studiando un metodo che fosse possibile replicare.
Inizialmente ci siamo dovuti concentrare sulla calibrazione e su alcuni aggiustamenti sul codice in MATLAB.
Trovato un punto di partenza che fosse abbastanza soddisfacente, ci si è concentrati sul miglioramento ed affinamento della tecnica di calibrazione e sui primi approcci alle misure svolte.
Quelle che ci interessavano maggiormente riguardavano il posizionamento del tag all’interno della stanza, sia per quanto riguarda il piano x-y, sia per quello che concerne l’altezza dal suolo, lo scopo principale, essendo il progetto concepito per andare ad investigare eventuali cadute, da parte dell’indossatore del tag.
Sono state svolte :
1- Misure di localizzazione;
2- Cammino con due tag contemporaneamente;
3- Prove di caduta e conseguente allarme.
Nell’elaborato verrà inizialmente presentato lo stato dell’arte, sia per quanto riguarda le antenne indossabili sia per le varie tecniche di localizzazione, le simulazioni svolte con la relativa realizzazione delle antenne patch ed infine tutti i risultati ottenuti dalle misurazioni di localizzazione effettuate.
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Burioli, Letizia. "Analisi di un setup di localizzazione di tag ibridi RFID-UWB." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/23968/.
Full textAbstract:
Questa tesi tratta l'identificazione e la localizzazione di tag ibridi RFID-UWB (Radio Frequency Identification - Ultra-Wide Band). Si compone di due attività principali, una riguardante l'elaborazione e l'analisi di dati provenienti da una campagna di misure e una relativa allo studio di un nuovo setup di misura tramite una periferica USRP, una Software Defined Radio (SDR). Inoltre, sono stati sviluppati nuovi codici contenenti algoritmi di tipo LS (Least Square) per la localizzazione di tag.
La tesi è strutturata come segue:
• Il Capitolo 1 motiva l'interesse nei confronti della tecnologia RFID e offre una panoramica sulle attività svolte;
• Il Capitolo 2 descrive i sistemi RFID, concentrandosi sul principio operativo della tecnologia e sui componenti, in particolare le diverse tipologie di tag;
• Il Capitolo 3 illustra il funzionamento del protocollo EPC Gen2-UHF, analizzando lo strato fisico e l'interfaccia logica;
• Nel Capitolo 4 viene proposto un nuovo possibile setup di misura che implementa un reader RFID mediante una periferica USRP. Vengono ripercorsi i passaggi seguiti durante l'attività ed illustrate le problematiche riscontrate;
• Il Capitolo 5 descrive il setup utilizzato durante una campagna di misure
precedente. Particolare attenzione è posta sul processo di localizzazione dei tag mediante un algoritmo di intersezione di ellissi. Vengono mostrate graficamente le posizioni dei tag così stimate in due scenari, che differiscono per l'orientazione delle antenne rispetto ai tag. Viene inoltre mostrato il procedimento seguito per compensare l'errore sistematico delle misure;
• Il Capitolo 6 descrive due algoritmi per la localizzazione di tag, un algoritmo di tipo TDOA (Time Difference Of Arrival) e uno di tipo TOA (Time Of Arrival), entrambi basati su un metodo Least Square;
• Nel Capitolo 7 viene mostrato il PEB (Position Error Bound) dell'algoritmo
TDOA e TOA precedentemente descritti, per diverse configurazioni dei ricevitori e del
trasmettitore.
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Söderberg, Madeleine. "Köper vi verket eller författaren? : En retorisk analys av detektivromanens omslag från 1940-tal till 2000-tal." Thesis, Uppsala universitet, Avdelningen för retorik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-167147.
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Detektivromanen är en genre som på senare år blivit omåttligt populär. Idag kan man köpa en deckare i nästan varje kiosk och matbutik. På detta följer att omslagen i de flesta fall måste sticka ut ur mängden för att boken ska bli såld, vilket sålunda gör det intressant att undersöka vilka metoder man använder – och har använt – för att locka läsare.
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Wickman, Lina. "Tal med ideologi : En analys av socialdemokratiska företrädares utsagor mellan 1928 och 1939." Thesis, Linköpings universitet, Institutionen för samhälls- och välfärdsstudier, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-79163.
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I min uppsats så har jag valt att studera den ideologi som ledde fram till skapandet av det svenska samhällets särart. Detta ämne har nu för tiden utvecklats till att i huvudsak vara historia, eftersom dess ursprung nu ligger så långt tillbaka i tiden. Mitt val av detta ämne beror huvudsakligen på att jag önskar öka förståelsen för hur välfärden och folkhemsidealet kom att utmärka Sverige. För att uppnå detta har jag främst studerat socialdemokratin, då den som det framgår i bakgrund och appendix var den drivande faktorn i denna utveckling. Jag har dock i den mån det påverkat det socialdemokratiska beslutsfattandet redovisat även andra faktorer. Därtill har jag valt att bege mig tillbaka till den tid då de första idéerna som skulle resultera i det socialdemokratiskt dominerade Sverige växte fram. Jag önskar nämligen också uppvisa hur socialdemokratins ideologi påverkades och förändrades under händelsernas inflytande för att därmed ge en mer heltäckande bild. Jag finner det även nödvändigt att beskriva den utveckling som ledde socialdemokratin fram till folkhemstanken för att ge en uppfattning om dess natur då dessa ideal började växa inom den. Naturligtvis så har jag bara kunnat täcka de mest basala delarna av ideologi och händelser, men jag har strävat efter att i den mån det är möjligt få med de viktigare tankegångarna. Mitt val av slutpunkt har bestämts delvis av det begränsade utrymmet i en studentuppsats, men också av övertygelsen att den värld som socialdemokratin samverkade med efter andra världskrigets slut hade förändrats fundamentalt. Mitt syfte med uppsatsen är att visa och analysera vad socialdemokrati betydde under tiden mellan 1928 och 1939 genom att analysera några av den tidens betydelsefulla socialdemokratiska tänkares uttalanden och skrifter. Min ambition är att i denna ideologianalys därmed kunna finna både deras gemensamma tankegångar och skillnaderna. Därtill har jag också för avsikt att undersöka de argument som socialdemokraterna använde sig av och därigenom få en uppfattning om vad de motsatte sig och varför. Min huvudfrågeställning är: Hur såg den socialdemokratiska ideologin ut under tiden mellan 1928 och 1939 tolkad genom olika socialdemokratiska röster? För att besvara den har jag valt att använda mig av följande frågor: Vad förespråkade socialdemokraterna? På vilka grunder kritiserade socialdemokraterna sina motståndare? Hur motiverade de det? I vilka sammanhang uttalade de sig? Kan skillnaden hänföras till personliga skillnader? Skälet till valet av dessa frågor är att jag finner att de i stort sett täcker den socialdemokratiska ideologin samtidigt som de bidrar till att placera den i sitt tidssammanhang.
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Lin, Zhiyuan. "On preparing co-workers for a preaching ministry : a study of II Timothy 2:1-26 = Cong Timotai hou shu er zhang 1-26 jie tan tao jiang dao shi feng tong gong de zai pei /." Theological Research Exchange Network (TREN), 2008. http://www.tren.com/search.cfm?p078-0054.
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Borghetti, Beatrice. "Sistemi RFID per applicazioni ciclistiche." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/12996/.
Full textAbstract:
In questo lavoro di tesi è stato realizzato e caratterizzato un sistema RFID che permette di rilevare e stimare la velocità di passaggio di biciclette lungo un percorso in cui si intende creare una "Green Wave", ovvero una corsia dedicata ai ciclisti che permette a chi la percorre di trovare sempre semafori verdi. Questa tesi affronta tematiche ispirate al progetto europeo XCYCLE volto a potenziare la sicurezza dei ciclisti.
Un sistema RFID è formato da un ricetrasmettitore (Reader) in grado di interrogare e rilevare trasponder a radiofrequenza di piccole dimensioni (Tag), e da un sistema informativo collegato al Reader che permette di gestire i dati contenuti nei Tag (Client).
Nel caso di questa specifica applicazione si è scelto di utilizzare due antenne collegate al Reader, poste ad una data distanza lungo la pista ciclabile, e si sono posizionati i Tag sulle biciclette che la percorrono con lo scopo di rilevare le loro direzioni e velocità.
Il Client comunica con il Reader tramite il protocollo standard LLRP; è stato quindi creato un software apposito che si occupa, tramite scambio di pacchetti LLRP, di stabilire una connessione con il Reader e interrogarlo per conoscere informazioni sui Tag rilevati, come ad esempio l'identificativo, l'istante di lettura e la potenza con cui si è ricevuto il segnale.
Si sono svolte attività sperimentali per stabilire le performance del sistema in termini di accuratezza nella stima della velocità: sono stati collocati su una bicicletta più Tag di vario tipo e in posizioni diverse, sono state disposte le antenne lungo la pista riservata al transito delle biciclette e, usando il software creato, si sono registrati i dati mentre la bicicletta veniva guidata nel tratto di strada.
Infine sono stati testati e valutati diversi algoritmi che, in base a questi dati raccolti, stimano la velocità di percorrenza di ogni Tag e quindi della bicicletta su cui sono stati applicati.
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Mikkola, Isak. "Does SCP-2 promote the expression of foreign proteins in Escherichia coli?" Thesis, Linköpings universitet, Biologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-129802.
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Expression of foreign proteins in host organisms usually results in the development of insoluble, inactive proteins. Further, these proteins have a tendency to form aggregates termed inclusion bodies. However, the formation of inclusion bodies can be avoided by fusing the gene encoding the foreign protein to a highly soluble protein. In this report Sterol Carrier Protein-2 (SCP-2) is reviewed as a possible solubility tag. The experiment was carried out by fusing SCP-2 to one of two i nsoluble proteins, Green fluorescent protein (GFP) or a form of chloramphenicol acetyl transferase (CAT∆9). The protein fusion was then inserted into the vector pET-15b, transformed in Escherichia coli and the yield of actively expressed protein was measured. The results obtained from this study, as evaluated by PageBlue staining and Western blot, are indicating that SCP-2 does not improve the solubility of GFP or CAT∆9. Nonetheless, the solubility of GFP has earlier been increased by fusing it to the solubility tag maltose-binding protein (MBP). Producing more soluble forms of CAT∆9 have also been tested but without success. Therefore the conclusion drawn from this experiment is that SCP-2 does not work as a solubility tag, however more research must be performed to conclude this with certainty.
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Marquié, Sayagués Marta. "Validación en tejido cerebral humano de [F-18]-AV-1451 (T807), un nuevo marcador de la proteína TAU-PHF para tomografía por emisión de positrones." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/400071.
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[F-18]-AV-1451 es un nuevo trazador para la detección de patología tau en vida del sujeto mediante tomografía por emisión de positrones (PET). [F-18]-AV-1451 fue originalmente creado para detectar tau en forma de filamentos de hélices pareadas (PHF) que conforman los ovillos neurofibrilares (ONF), una de las lesiones características de la Enfermedad de Alzheimer (EA). Pacientes con EA tienen una mayor captación in vivo de [F-18]-AV-1451 en la neocorteza comparados con ancianos cognitivamente sanos. En este trabajo se investigaron los sustratos neuropatológicos y los patrones regionales de la señal de [F-18]-AV-1451 en tejido cerebral de casos con y sin presencia de tau usando autoradiografía con pantalla de fósforo, autoradiografía con emulsión nuclear, ensayos de unión in vitro y cuantificación bioquímica de tau con SDD-AGE. También se estudiaron tres individuos que fueron evaluados con PET-[F-18]-AV-1451 en vida y al fallecer se sometieron a autopsia. Los resultados sugieren que [F-18]-AV-1451 se une intensamente a agregados formados por tau-PHF, incluyendo ONFs y neuritas distróficas, en los cerebros con EA. [F-18]-AV-1451 no tiene una afinidad significativa por filamentos rectos (FR) de tau en taupatías distintas a la EA ni por β-amiloide, TDP-43 o α-sinucleína. Se identificó una señal fuera de diana en la neuromelanina que podría explicar la captación in vivo hallada en la sustancia negra. Los tres sujetos que fueron evaluados con PET-[F-18]-AV-1451 en vida y al fallecer se les realizó autopsia tenían un diagnóstico clínico de Parálisis Supranuclear Progresiva (n=2) y Demencia frontotemporal portador de la mutación del gen MAPT P301L (n=1). La neuroimagen con PET mostró intensa captación en los ganglios basales y el mesencéfalo, y menor señal en otras regiones frontales y temporales. El examen neuropatológico confirmó el diagnóstico de PSP en dos casos mientras que en el portador de la mutación P301L se evidenciaron pequeños granos tau+ de predominio en los ganglios basales. La autoradiografía no detectó señal significativa de [F-18]-AV-1451 ni unión a las lesiones de tau-FR, con la excepción de señal en la corteza entorrinal (ONFs relacionados con el envejecimiento) y en la sustancia negra. Los análisis de correlación entre la captación regional del trazador in vivo con los ensayos de unión in vitro y el SDD-AGE no mostraron ninguna asociación significativa. En resumen, estos datos de sugieren que [F-18]-AV-1451 se une principalmente a los agregados de tau-PHF en la EA y tiene una afinidad relativamente baja para las lesiones de tau formadas por FR en taupatías distintas a la EA. También se evidenció la señal de [F-18]-AV-1451 en las neuronas con neuromelanina en la sustancia negra, que podría explicar la señal in vivo en el mesencéfalo.[F-18]-AV-1451 is a novel tracer for the in vivo detection of tau pathology using emission positron tomography (PET). [F-18]-AV-1451 was originally raised against paired helical filament (PHF)-tau, which if found in neurofibrillary tangles (NFTs), one of the characteristic lesions in Alzheimer´s disease (AD). AD patients show higher in vivo [F-18]-AV-1451 retention compared to elderly cognitively normal individuals in neocortical regions. In this project we investigated the neuropathological substrate and regional patterns of [F-18]-AV-1451 signal in brain tissue from cases with and without tau, using phosphor screen autoradiography, nuclear emulsion autoradiography, in vitro binding assays and biochemical quantifications of tau with SDD-AGE. We also analyzed three individuals who were evaluated with PET-[F-18]-AV-1451 when alive and came to autopsy. The results suggest that [F-18]-AV-1451 strongly binds to PHF-tau including both NFTs and dystrophic neurites in AD brains. [F-18]-AV-1451 does not have a significant affinity for straight filaments (ST) of tau in non-AD tauopathies, neither for β-amyloid, TDP-43 and α-synuclein. We identified an off-target signal to neuromelanin that could explain the in vivo uptake detected in the substantia nigra. The three subjects who were evaluated with PET-[F-18]-AV-1451 when alive and came to autopsy had a clinical diagnosis of Progressive Supranuclear Palsy (PSP, n=2) and frontotemporal dementia carrier of the MAPT P301L mutation (n=1). PET showed the highest in vivo uptake in the basal ganglia and the midbrain, and milder signal in other frontal and temporal regions. The neuropathological exam confirmed the PSP diagnosis in two cases, and the exam of the carrier of the P301L mutation showed small tau+ grains predominantly in the basal ganglia. Autoradiography failed to detect a significant [F-18]-AV-1451 signal, neither binding to SF-tau lesions. The only exceptions were the entorhinal cortex (age-related NFTs) and the substantia nigra. The correlation analysis between the in vivo tracer uptake with in vitro binding assays and SDD-AGE did not show any significant association. To conclude, these data suggest that [F-18]-AV-1451 mainly binds to tau-PHF aggregates in AD and has a relatively low affinity to SF-tau lesions in non-AD tauopathies. We also detected [F-18]-AV-1451 off-target signal in the neuromelanin-containing neurons of the substantia nigra, which could explain the universal in vivo midbrain uptake.
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Lancaster, Sarah Renee. "Soil microbial response to glyphosate-base cotton pest management systems." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2636.
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Chikh, Amina. "Développement d'une thérapie pour l'Ataxie de Friedreich basée sur l'administration des protéines Tat-Frataxine et Pep-1-Frataxine." Master's thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/26278.
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L’Ataxie de Friedreich est une maladie génétique rare et grave, associant une neurodégénérescence, une cardiomyopathie et un diabète. Elle est causée par une réduction drastique d’une protéine mitochondriale appelée frataxine. L’approche de notre laboratoire sera donc de développer sur des cellules en culture et dans un modèle animal une thérapie moléculaire qui aura pour but de fournir aux cellules une protéine frataxine recombinante et réduire si possible les symptômes de la maladie. Afin de permettre la transduction de la frataxine, nous l'avons fusionné à un domaine de transduction protéique (Cell Penetrating Peptides, CPP) comme Tat ou Pep-1. Ces peptides sont bien connus pour leur capacité d’acheminer, dans les cellules, les protéines auxquelles ils sont fusionnés par des vésicules d’endocytose, mais également d’être libérées de ces derniers pour participer au métabolisme de la cellule. Des observations préliminaires obtenues, nous concluons que les protéines Tat-Frataxine et Pep-1-Frataxine assurent in vitro et in vivo la viabilité des cellules déficientes en frataxine endogène.Friedreich Ataxia is a rare and serious genetic disease involving neurodegeneration, cardiomyopathy and diabetes. It is caused by a drastic reduction of a mitochondrial protein called frataxin. The approach of the laboratory will be to develop on in vitro cells and in vivo mice models, a molecular therapy that will aim to provide the cells with a recombinant protein frataxin and if possible reduce the symptoms of the disease. To enable transduction of frataxin, we fused it to a protein transduction domain (Cell Penetrating Peptides, CPP), Tat or Pep-1. These peptides are well known for their ability to allow the penetration into the cells of the proteins to which they are fused through endocytosis vesicles, but also to be released from these vesicles to take part in the cell metabolism. Preliminary observations led us to conclude that the Tat-Frataxin and Pep-1-Frataxin protein enhance in vitro and in vivo the viability of cells deficient in endogenous frataxin.
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SANTOS, Erlon Oliveira dos. "Caracterização molecular do Vírus Linfotrópico de células T de humano (HTLV) em pacientes com paraparesia espástica tropical/mielopatia (PET/MAH), portadores e gestantes em Alagoas." Universidade Federal de Pernambuco, 2013. https://repositorio.ufpe.br/handle/123456789/11703.
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Submitted by Ramon Santana (ramon.souza@ufpe.br) on 2015-03-10T17:37:43Z
No. of bitstreams: 2
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license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5)Made available in DSpace on 2015-03-10T17:37:43Z (GMT). No. of bitstreams: 2 TESE Erlon dos Santos.pdf: 1734297 bytes, checksum: 205753dd558082606a830dc4239e9826 (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Previous issue date: 2013-06-13
Os vírus linfotrópicos de células T humana tipos 1 e 2 (HTLV-1/2) são retrovírus associados a algumas doenças. O HTLV-1 está associado à paraparesia espástica tropical/mielopatia (PET/MAH), enquanto o HTLV-2 tem sido ocasionalmente associado às síndromes neurológicas semelhantes a PET/MAH sem associação de malignidade. Os mecanismos envolvidos no surgimento das doenças ainda não estão bem definidos. Entretanto, a carga proviral do HTLV, as mutações e a proteína tax podem está envovolvidas no desenvolvimento da doença. Os objetivos do presente estudo foram caracterizar o HTLV em pacientes com PET/MAH e portadores e determinar a soroprevlência desses vírus em gestantes durante o pré-natal. O DNA proviral foi extraído a partir de células periféricas mononuclares, utilizando o kit comercial (QIAamp® DNA Blood Mini Kit) e a identificação do tipo viral foi realizada através da Nested-PCR. Já a carga proviral do HTLV-1 pela PCR quantitativa - expressas em 106/PBMC. Para classificar a sequência tax, foi utilizada a enzima de restrição Bsh1236I (BstUI). Na pesquisa do anti-HTLV1/2 nas gestantes foi utilizado o KIT ELISA Ab capture ELISA Teste System (Ortho clinical Diagnostic In, Raritan, USA). Foi utilizado o Teste de Fisher, Mann-Whitney para avaliar a média da carga proviral. A Razão de prevalência, qui-quadrado (x2) e exato de Fischer foram utilizados para determinar as associações entre as gestantes. O poder do teste foi de 95%, com p<0,05 como limite para a significância. Fizeram parte do estudo 101 pacientes infectados pelo HTLV 1/2 - sintomáticos e assintomáticos e 209 gestantes. O HTLV-1 foi identificado em 68,3% (69/101) e o HTLV-2 em 31,7% (32/101). A média da carga proviral do HTLV-1 nos pacientes portadores foi de 3,62 log10; DP ± 0,960; IC95% 3,31-3,93 e naqueles com PET/MAH foi de 3,18 log10; DP 1,261; IC95% 2,68-3,68 (p = 0.0218). Em relação à sequência tax do HTLV, o subgrupo A foi identificado em 95,7% (66/69) e o B em 4,3% (3/69). A soroprevalência do HTLV1/2 nas gestantes foi de 8,1% (17/209). O DNA proviral do HTLV-1 foi identificado em 64,2% (9/14), com média da carga proviral de 3,17 ± 1,87 log10. As demais amostras foram negativas para o HTLV-1. Todas as gestantes encontravam-se assintomáticas e nenhuma variável pesquisada apresentou associação estatisticamente significativa. Em conclusão, não houve diferença entre a média da carga proviral do HTLV-1 entre os pacientes com PET/MAH e portadores. Houve uma maior frequência do subgrupo A da sequência tax nos pacientes com PET/MAH, sem associação com o desenvolvimento da doença. Foi elevada a prevalência da infecção pelo HTLV-2 nos portadores. A alta soroprevalência do HTLV-1/2 nas gestantes sugere a implantação da triagem deste vírus no pré-natal.
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Park, Yong Hun. "Investigation of the performance and water transport of a polymer electrolyte membrane (pem) fuel cell." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2549.
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Rivas, Cardona Juan Alberto. "Development of a microfluidic device for patterning multiple species by scanning probe lithography." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1823.
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Cavotta, Chiara. "Sviluppo di applicazioni Android per la gestione di tecnologie NFC." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2018.
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Il seguente elaborato descrive le primitive del sistema operativo Android per la gestione di tecnologie NFC. Si concentra prettamente su analisi e sviluppo software di lettura e scrittura su tag NFC e lo sviluppo di un sistema di autenticazione basato su tecnologia NFC. Le applicazioni sono state sviluppate tramite la piattaforma di programmazione Android Studio.
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Ferilli, Lorenzo. "Modelli ad elementi finiti personalizzati da dati TAC per la valutazione del rischio di frattura del collo del femore." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19039/.
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La frattura del collo femorale è una condizione clinica frequente in soggetti osteoporotici, per i quali rappresenta la principale causa di invalidità, perdita di autosufficienza e mortalità. Sin dallo scorso millennio è stata adottata una politica di valutazione del rischio di frattura femorale attraverso operazioni di screening della popolazione effettuate seguendo varie modalità, fra le quali il metodo degli elementi finiti. Il lavoro si concentra sull'applicazione dei processi di segmentazione di un'immagine DICOM, l'ottenimento di una mesh tridimensionale, l'impostazione e l'avvio di una simulazione strutturale statica eseguita attraverso il metodo degli elementi finiti, allo scopo di valutare l'applicabilità di questa metodologia in operazioni di screening della popolazione e di valutazione del rischio di frattura del femore.
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Finster, Sabrina. "Charakterisierung der Funktion und Lokalisation der plastidären Genexpressionsmaschinerie in Nicotiana tabacum." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17238.
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Die Transkription der Chloroplasten ist erstaunlich komplex. Ihr relativ kleines Genom kodiert für Komponenten der Photosynthese und der eigenen Genexpressionsmaschine. Es wird mindestens durch zwei RNA Polymerasen transkribiert. Neben der plastidär kodierten RNA Polymerase (PEP), existiert mindestens eine weitere kernkodierte RNA Polymerase (NEP). Die PEP spielt eine wichtige Rolle bei der Expression der Photosynthesegene und ist essentiell für die Biogenese der Chloroplasten und schließlich für das Überleben der Pflanzen. In der vorliegenden Arbeit wird erstmals die spezifische Interaktion der PEP mit ihren Transkriptionseinheiten unter verschiedenen Lichtbedingungen in vivo auf plastomweiter Ebene gezeigt. Darunter befinden sich hauptsächlich DNA Fragmente, die Photosynthesegene repräsentieren. Außerdem zeigt die PEP eine eindeutige Präferenz zu den rRNA Genen und einigen tRNA Genen. Eine Reduktion dieser Assoziation der PEP in Dunkelperioden lässt einen lichtabhängigen Prozess bei der PEP-DNA Assoziation vermuten. Außerdem wurde die PEP Aktivität an den bestimmten DNA Regionen in vivo ermittelt durch die Analyse naszierender Transkripte. Ein Großteil der plastidären RNA Spezies kopräzipitiert mit der PEP, aber sie scheint präferentiell mit tRNAs zu interagieren. Die Analyse der Verteilung der PEP bewies erstmals, dass sie hauptsächlich mit den Membranen assoziiert. Dort befindet sich auch das transkriptionsaktive Chromosom (TAC). Im TAC wurden vor kurzem neben der PEP auch Mitglieder von RNA Prozessierungsfaktoren identifiziert, was auf eine mögliche Kopplung von Transkription und posttranskriptionellen Prozessen hindeutet. Für einen Einblick in dieses Interaktionsnetzwerk wurden Transkriptanalysen des TACs ausgeführt. Mit wenigen Ausnahmen assoziieren alle plastidären RNA Spezies mit dem TAC. Einige RNAs liegen bereits prozessiert vor, was eine Verbindung zwischen Transkription und posttranskriptionellen Prozessen noch im TAC vermuten lässt.Chloroplast transcription is astonishingly complex. The relative small genome of plastids, which codes for components of the photosynthetic machinery as well as for components of their own gene expression machinery, is transcribed by at least two different RNA polymerases. Beside the plastid-encoded plastid RNA polymerase (PEP) a nuclear-encoded plastid RNA polymerase (NEP) exists as well. PEP plays a major role in the expression of photosynthesis genes and is essential for chloroplast biogenesis and thus for plant survival. This work shows the specific in vivo interaction between PEP and its transcription units under different light conditions on a plastome-wide scale. Among them are DNA fragments that represent photosynthetic genes. In addition, PEP shows clear preferences to rRNA and tRNA genes. Furthermore, the association of PEP with photosynthesis-related genes was reduced during the dark period, indicating that PEP-DNA association is a light-dependent process. To survey PEP activity in vivo on plastid DNA regions, the association to nascent transcripts was analyzed. The majority of plastid RNA species could be found in PEP precipitates, but PEP seems to interact more strongly with tRNAs. Analysis of the suborganellar distribution of PEP shows that PEP is preferably associated with chloroplastmembranes. The transcriptionally active chromosome (TAC) was also found to be membrane-attached. Beside PEP different RNA processing factors were identified within the TAC and related purifications, indicating a possible coupling of transcription and posttranscriptional processes. To gain more insights into this interaction network, transcripts of TAC were analyzed. It is shown that nearly all plastid RNA species with only a few exceptions are associated to the TAC and that at least selected transcripts are already processed. This indicates that there is a link between transcription and posttranscriptional processes already within the TAC.
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Roche, Mélanie. "Stratégies innovantes pour le radiomarquage de macro-biomolécules au fluor-18 pour des applications en imagerie moléculaire in vivo." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS031/document.
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Le radiomarquage des macro-biomolécules au fluor-18 représente un défi majeur en radiochimie vu leur importance en imagerie moléculaire. Les macro-biomolécules et en particulier les peptides offrent une diversité moléculaire et un ciblage in vivo souvent plus spécifiques et sélectifs que les molécules de plus faibles poids moléculaires. Cependant, les conditions standards de radiomarquage au fluor-18 seraient destructrices pour de tels composés et ne peuvent être utilisées directement. Peu de méthodes directes de radiomarquage existent et présentent certains inconvénients (température encore élevée, activité molaire faible, méthodes peu versatiles…). C’est pourquoi, le radiomarquage par approche prosthétique en deux étapes reste une méthode de choix. Cette stratégie séquentielle implique tout d’abord la préparation d’une molécule radiofluorée, appelée groupe prosthétique, puis sa conjugaison à la macro-biomolécule dans des conditions chimiques biocompatibles. L’objectif de ce travail de thèse a consisté à développer de nouvelles méthodes générales de radiomarquage de macro-biomolécules visant in fine des applications de radiomarquage direct in vivo. Les enjeux principaux ont été la diminution du temps de marquage pour améliorer les procédés de radiosynthèse compte tenu de la demi-vie du fluor-18 (109,8 min), le besoin d’automatisation ainsi que la vitesse et la bioorthogonalité des réactions de conjugaison pour des applications en milieu complexe et dilué. Tout d’abord, l’étude de trois réactions de chimie click, CuAAC, SPAAC et SPSAC, de vitesse et de biocompatibilité croissantes a été considérée. Le développement de groupes prosthétiques spécifiques de chacune d’entre elles ainsi que leur conjugaison sur des composés modèles ont ensuite été étudiés. Par la suite, une étude méthodologique sur la radiofluoration de pyridines substituées a été initiée afin d’obtenir des entités radiomarquables dans des conditions suffisamment douces permettant la « pré-conjuguaison » à la macro-biomolécule avant l’étape de radiofluoration. Enfin, l’utilisation d’un étiquetage enzymatique, le SNAP-tag, a également été explorée et un substrat radiofluoré spécifique synthétisé. Ces différentes approches ont permis d’élargir le panel des méthodes permettant un radiomarquage efficace et biocompatible de macro-biomoléculesFluorine-18 radiolabeling of biologics is a challenge in radiochemistry due to their increasing interest in molecular imaging. Biologics, and particularly peptides, offer molecular diversity and often higher specific and selective in vivo targeting compared to low molecular weight molecules. However, fluorine-18-radiolabeling standard conditions could not be used directly because biologics would suffer from these drastic conditions. Only a few direct radiolabeling methods are available and present some drawbacks (high temperature, low molar activity, lack of versatility…). Therefore, a two-steps prosthetic radiolabeling approach remains the method of choice. This sequential strategy involves the preparation of a fluorine-18-labeled molecule, called prosthetic group, which is then conjugated with the macromolecule in biocompatible chemical conditions. The aim of this PhD work was to develop new general methods for the radiolabeling of biologics directed toward in vivo radiolabeling applications. Major issues were time and radiosynthesis processes with regard to the fluorine-18 half life, automatization as well as constant rate and bioorthogonality of conjugation reactions for applications in complex and diluted environment.The first part is devoted to the study of three click chemistry reactions, CuAAC, SPAAC and SPSAC leading to enhanced reaction rates and biocompatibility. Specific prosthetic groups were developed for each reaction and their conjugation was studied with model compounds. Furthermore, a methodological study involving the radiofluorination of substituted pyridines was initiated for the production of entities for mild radiolabeling conditions compatible with a “pre-conjugation” to the biologics before radiofluorination. Finally, an enzymatic labeling approach using the SNAP-tag self-labeling enzyme was explored and a specific radiofluorinated substrate was synthesized. These different approaches allowed an extent of the panel of methods for effective and biocompatible radiolabeling of biologics
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Mugianesi, Francesca. "Modelli statistici per l'organizzazione della struttura tridimensionale del DNA umano." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/12342/.
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Il grande sviluppo della tecnica di genome-wide conformation capture (Hi-C) permette di indagare la complessa ed interessante relazione che intercorre tra la struttura 3D dinamica organizzata gerarchicamente della cromatina e la funzionalità del genoma.
In altre parole, questa tecnica consente di avere informazioni tridimensionali sulla struttura dei nuclei delle cellule. Il lavoro di tesi
si è incentrato sullo studio multirisoluzione dei domini topologici (TAD) della cromatina di sette tipi cellulari umani. L'algoritmo impiegato è basato sulla segmentazione spettrale iterativa del laplaciano normalizzato associato alla mappa intra-cromosomiale Hi-C. L'analisi dei dati ha rivelato che i TAD boundary tendono ad una distribuzione spaziale regolare, conservata tra tipi cellulari.
É possibile che il maggior grado di similarità riscontrato tra alcune linee cellulari abbia basi biologicamente rilevanti. Le dimensioni dei TAD individuati vanno da ∼ 450 kb, con i dati alla risoluzione di 50 kb, fino a ∼ 4.7 Mb, alla risoluzione di 1 Mb, e risultano indipendenti dalla lunghezza specifica del cromosoma.
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Fiorentino, Marco. "Sviluppo di un configuratore di giochi per un parco divertimenti." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2018.
Find full textAbstract:
Sviluppo di un sistema di giochi alternativo per i parchi divertimenti che possa andare ad integrare le attrazioni già esistenti, fornendo ai visitatori delle possibilità di divertimento in iù
Il sistema si sviluppa tramite un'applicazioni mobile di gestione, tre installate in alcuni totem dislocati nel parto ed un braccialetto dotato di tag RFID fornito al cliente che cosi può interagire con la struttura.
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Mauri, Paytubí Eduard E. "Maneig radiològic dels petits nòduls pulmonars: valoració crítica de la punció guiada per TAC i de la col·locació prequirúrgica d’arpons." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/117788.
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Introducció: El motiu del treball no és només exposar com apliquem les tècniques intervencionistes als petits nòduls pulmonars definits com aquells que fan aproximadament un centímetre o menys, fent una revisió critica de la nostra experiència en puncions i col·locació d’ arpons, sinó sobretot demostrar la necessitat de realitzar un canvi en el protocol de maneig d'aquests pacients, en el sentit que s'ha de ser més pràctics i més resolutius , ja que pensem que no podem estar esperant fent proves i controls evolutius, quan un pacient pot o no tenir una metàstasi o un primari, sabent que la cirurgia ofereix molt bons resultats en els tumors de menys de 2 cm.
Material i mètodes: Es fa una revisió de la situació actual del maneig dels nòduls petits tant dels que es troben a l’estadiatge o seguiment de les neoplàsies , com els que es troben en els estudis pulmonars de screening o son troballes casuals de un estudi radiològic (RX simple o TC) en un altre context clínic . Es fa un estudi retrospectiu de les 122 puncions efectuades i un estudi dels primers nou casos ( treball de recerca de doctorat) en que es va aplicar la tècnica de col·locació d’ arpons abans de una videotoracoscòpia per a marcatge dels esmentats nòduls. S ‘exposa el disseny de l’estudi prospectiu amb’ un nou protocol basat en uns criteris de sospita clinico-radiològica ( 194 pacients amb estudi completat). Es tracta de agrupar els diferents paràmetres clínics i radiològics del pacients en quatre graus bàsics de sospita i aplicar en cada cas els criteris proposats.
Resultats: Per a la discussió dels resultats es compara amb els resultats anatomopatològics obtinguts com a gold standard i la literatura existent sobre el tema . De l’ estudi retrospectiu hem vist la seva alta eficàcia (“accuracy”) condicionada en primer lloc a la experiència en puncions pulmonars de l’ operador. Hi ha un segon factor d’ experiència dels anatomopatòlegs en el maneig i interpretació de les mostres. Tot això fa difícil generalitzar la tècnica fins que no s’ adquireix per les dues parts una llarga experiència. La tècnica de col•locació de l’ arpó prèvia a videotoracoscòpia ha estat molt útil doncs ens permet sempre obtenir un diagnòstic i sovint el tractament , dels nòduls petits, alhora que resol l’ angoixa del malalt i del metge que el porta al resoldre definitivament els dubtes que hi pot haver sobre la seva naturalesa. L’ evolució tècnica de la videotoracoscòpia li dona moltes possibilitats de intervenir amb baix risc tant en el diagnòstic com la resecció dels nòduls.
Conclusions: l’ aplicació de les dues tècniques esmentades , de una manera sistematitzada dins un protocol aplicat amb uns criteris de sospita ben definits, ens permet un maneig àgil i ràpid dels nòduls petits. Amb el protocol aplicat aconseguim ser més resolutius del que veníem essent fins ara. Reduïm l’ angoixa del malalt i del clínic al donar més seguretat a la conducta adoptada i escurçar l’ obtenció de diagnòstic. Veiem que les perspectives que teníem al dissenyar el protocol es corresponen bastant al que esperàvem obtenir. Perquè? Doncs senzillament perquè l’ experiència ja ens dona una certa “evidencia” del que cal fer. El treball prospectiu ens confirma això i ens permet sobretot poder plantejar la necessitat de aplicar un protocol guiat pel grau de sospita amb les eines intervencionistes que tenim.
Per tot això recomanem aquest protocol pel maneig dels nòduls petits pulmonars que es puguin trobar en l’ estudi dels malalts ja sigui amb neoplàsia coneguda o no.Introduction: The aim of this study is double. First, to show how we have applied interventional techniques to small pulmonary nodules (10 mm or less), adding a critical review of our experience with punctures and placement of harpoons. Second to demonstrate there is a need to change the management algorithm of these patients, in the sense that we have to be more practical and more resolute. We think that we can’t be expecting evolutionary testing and monitoring when a patient may have a primary or metastatic tumor, knowing that surgery provides excellent results in tumors less than 2 cm. Methods: We have performed a review of the current status of the management of small nodules. We have focused on both staging and monitoring of tumors, such as those found in lung screening studies (RX or TC) or in another clinical setting. We present a research-based doctoral study with the first nine cases in which the technique was applied. The placement of the harpoons was done before a videothoracoscopy (VATS). We present the design of a prospective study with a new protocol based on criteria of suspicion (194 patients completed study). These pooled clinical and radiological parameters of the patients in four basic levels of suspicion and applied in each case the proposed approaches. Results: Our results are compared with those existing in the literature, taking histological final results as the gold standard. In the retrospective study we have noticed the high accuracy of this technique depending first on the experience in lung punctures of the radiologist, and a second on the pathologists experience in handling and interpreting samples. These conditions make it difficult to generalize the technique as it is not easy to acquire a long experience by both parties. The technique of placing the harpoon before VATS is very useful as it always permits to get a diagnosis and often in addition to treat the small nodules, this makes possible to resolve the anxiety of the patient and doctor having no doubts about the small nodules nature. The technical evolution of VATS gives more possibilities to surgery, with lower risks in diagnosis and resection of the nodules. Conclusions: The application of the two techniques mentioned, a systematic protocol applied in a suspected well-defined criteria, allows a fast and agile handling of small nodules. In a future the protocol applied in this study has to become more decisive than it is now. It will make possible to reduce the anxiety of the patient and the clinician and will provide security in the conduct adopted. It will also shorten the time to obtain a histological diagnosis. We have checked that final results obtained with our protocol accomplish our initial perspectives. Why? Well, simply because experience gives us some "evidence" of what to do. Our prospective study confirms this and allows us to consider the need to implement a protocol guided by clinical suspicion interventionist with the tools we have. So we recommend this protocol to manage small pulmonary nodules that may be found in the study of cancer patients (known or not).
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Gargate, Rohit Vasant. "Synthesis and characterization of carbon nanotubes using scanning probe based nano-lithographic techniques." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3191.
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Foster, Martie. "Withholding tax on services : a square peg in a round hole? : an analysis of intra-group cross border services in the context of source, related transfer pricing principles and witholding taxes." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/13146.
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Includes bibliographical references.Various countries have extended the levying of withholding taxes beyond the traditional withholding taxes on royalties, dividends and interest. Withholding taxes are now often levied on services such as management services, professional services, technical services, financial services, insurance services, fees, commission, advisory services and digital services, amongst others. The purpose of this paper is to consider the impact of these withholding taxes on certain services, in particularly intra-group cross border services in the context of source and related transfer pricing principles.
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Huitink, David Ryan. "Nanolithographic control of carbon nanotube synthesis." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2539.
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Hörnell, Christina. "Thermochemical and Catalytic Upgrading in a Fuel Context : Peat, Biomass and Alkenes." Doctoral thesis, KTH, Chemical Engineering and Technology, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3164.
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Ricci, Beatrice. "Sviluppo di un'applicazione Android per il supporto all'acquisto di prodotti in negozio." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/12177/.
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Questo elaborato, dopo una breve parte dedicata alle tecnologie utilizzate per lo sviluppo ed all'effettiva usabilità del software, va a descrivere le fasi di progettazione ed implementazione che hanno portato alla realizzazione della app MyShopAssistant. All'interno della tesi vengono ampiamente descritte le casistiche in cui l'uso della suddetta applicazione può facilitare il momento della scelta e dell'acquisto di un prodotto in un negozio di abbigliamento. Viene descritto poi come l'applicazione in questione sia per ora un prodotto unico nel suo genere sul mercato, differenziandosi dai comuni servizi di e-commerce.
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Gunnarsson, Marcus, and Olof Palmquist. "Mätning och utvärdering av intellektuellt kapital inom aktiemarknaden." Thesis, Växjö University, School of Management and Economics, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-755.
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Organisation/Organisation Författare/Authors
Växjö Universitet Marcus Gunnarsson
Ekonomihögskolan Olof Palmquist
Växjö University
School of Management and Economics
Dokumenttyp/Type of document Handledare/Tutor
Examensarbete/ Diplomawork Stig Malm Examinator/Examiner
Rolf G Larsson
Titel och undertitel/Title and subtitle
Mätning och utvärdering av intellektuellt kapital inom aktiemarknaden/ Measurement and evaluation of intellectual capital within the stock market
Sammanfattning
Bakgrund: I dagens hårda konkurrens i samhället går trenden mot en informations- och kunskapsbaserad ekonomi där kunskapsföretagen blir fler och fler. Den största tillgången i företagen är de anställda och deras kompetens. Denna kompetens kan omvandlas till en värdefull tillgång och benämns som intellektuellt kapital. Trots att det finns ökad förståelse för att det intellektuella kapitalet skapar mervärde för företaget finns det hinder med att redovisa detta då det inte får tas upp i balansräkningen.
Syfte: Uppsatsens syfte är att analysera huruvida intellektuellt kapital är något som fondförvaltare utvärderar när de gör en investeringsbedömning.
Avgränsningar: Begränsningarna är att vi undersöker hur intellektuellt kapital kan vara till fördel för endast fondförvaltare; vi analyserar olika fondförvaltare i deras arbete endast med en investeringsbedömning. En sista avgränsning är att vi valt att inte tillfråga de fondförvaltare som inte utvärderar intellektuellt kapital aktivt i sina investeringsbedömningar.
Metod: Vi har utgått från en kvantitativ metod och har genomfört en enkätundersökning för insamling av material. Resultatet har vi analyserat utifrån den teori som vi tagit upp i det teoretiska kapitlet. Ansatsen är av abduktiv karaktär åt det deduktiva hållet då vi har studerat existerande teorier och fallstudier inom ämnet.
Resultat, slutsatser: Svenska fondanalytiker lägger inte särskilt stor vikt på intellektuellt kapital när de utvärderar och analyserar ett företag. Grunden till detta är för det första att det är svårt att mäta trovärdigheten av intellektuellt kapital när företagen själva sammanställer och redovisar detta utan att kontrolleras av någon utomstående part. För det andra är korrelationen mellan större delen av ett företags strukturkapital och aktiens utveckling på börsen inte påvisbar.
Förslag till fortsatt forskning: Ett redovisningssystem för intellektuellt kapital som är lika för alla inom samma bransch möjliggör fortsatt forskning inom ämnet med syftet att finna en analysmetod som påvisar eller dementerar förändringen av ett företags intellektuella kapital med företagets aktierörelse på börsen.
Nyckelord
Intellektuellt kapital, Humankapital, Strukturkapital, Kundkapital, Immateriella tillgångar, Soliditet, Likviditet, Lönsamhet, P/E-tal, PEG-tal, P/S-tal
Key Words
Intellectual capital, Human capital, Capital structure, Customer capital, Immaterial assets, Solidity, Liquidity, Profitability, P/E, PEG, P/S
Utgivningsår/Year of issue Språk/Language Antal sidor/Number of pages
2006 Svenska/Swedish 37
Internet: http://www.vxu.se/ehv
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Reggi, Emanuele. "Metodi euristici per il problema dei trasporti con costi fissi." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amslaurea.unibo.it/6016/.
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In questa tesi viene considerato il problema dei trasporti con costi fissi (FCTP) che, assieme al Traveling Salesman Problem (TSP), è uno dei problemi nobili dell’ottimizzazione combinatoria. Esso generalizza il ben noto problema dei trasporti (TP) imponendo che il costo per spedire prodotti da un’origine ad una destinazione sia composto da un costo fisso ed un costo proporzionale alla quantità spedita.
Il FCTP è stato formulato per la prima volta in un articolo di Hirsch e Dantzig (1968) ed è stato da allora oggetto di studio per la ricerca di nuovi e sempre migliori algoritmi di risoluzione. Nessuno dei metodi esatti fin ora pubblicati è in grado di risolvere istanze con più di 15 origini e 15 destinazioni. Solo recentemente, Roberti et al. (2013), in un paper in corso di pubblicazione, hanno presentato un metodo esatto basato su una nuova formulazione matematica del problema, il quale è in grado di risolvere istanze di FCTP con 70 origini e 70 destinazioni.
La crescita esponenziale dello sforzo computazionale richiesto dai metodi esatti ne ha confinato l’applicazione a problemi di dimensioni ridotte.
Tali limitazioni hanno portato allo studio e alla ricerca di approcci approssimativi, euristici e metaeuristici i quali sfruttano varie strategie di local search. Fra i molteplici metodi euristici presentati in letteratura, meritano particolare attenzione quelli di Sun et al. (1998) e Glover et al. (2005). Recentemente, Buson et al. (2013) hanno presentato un nuovo euristico che domina tutti i precedenti sui problemi test proposti in letteratura.
In questa tesi viene presentato un approccio Tabu Search che migliora il metodo originalmente proposto da Sun et al. (1998). I risultati computazionali ottenuti con un codice prototipale indicano che l’algoritmo sviluppato è migliore del metodo originario di Sun et al. (1998) e competitivo con il più recente metodo proposto da Buson et al. (2013).
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Bouti, Salima. "Etude du vieillissement thermique à long terme du PET : application à l'isolation électrique dans des disjoncteurs haute tension." Thesis, Vandoeuvre-les-Nancy, INPL, 2011. http://www.theses.fr/2011INPL017N.
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Les isolateurs diélectriques utilisés dans les disjoncteurs haute tension développés par Areva, sont fabriqués à partir du PET (polyéthylène téréphtalate). Ce polymère semi-cristallin a remplacé, depuis quelques années, les résines époxy. Il a été choisi pour ses propriétés mécaniques et diélectriques, mais surtout pour sa recyclabilité. Le souci dans cette application, concerne l’évolution dans le temps de ses caractéristiques sachant les contraintes d’application. En effet, dans les conditions de travail, les isolateurs maintiennent des conducteurs électriques. Les pertes thermiques affectent certaines zones pouvant atteindre, voire dépasser, la température de transition vitreuse du matériau [70-80°C]. Par conséquence, les pièces isolatrices subissent un phénomène de vieillissement qui nécessite un suivi dans le temps afin d’étudier l’évolution de leur caractéristiques Dans ce contexte, nous avons étudié le vieillissement thermique du PET. Ainsi des échantillons ont été mis dans des étuves sous vide, chacune réglée à une température : 60, 80, 115 et 125°C pendant différentes durées (jusqu’à 12 mois de vieillissement), puis retirés et testés au fur et à mesure du vieillissement. Différentes techniques ont été employées pour analyser les propriétés du semi-cristallin en question, i.e. l’étude calorimétrique différentielle (DSC), les diffractions aux rayons X aux grands et petits angles (WAXS/SAXS). L’analyse thermomécanique (DMA) et finalement les essais de traction.Les résultats de DSC révèlent une augmentation du taux de cristallinité. Les analyses thermomécaniques ont montré une faible augmentation du module de Young qui pourrait être le résultat d’une évolution de la cristallisation. Les températures de fusion sont restées quasiment stables, par contre une augmentation des températures de transition vitreuse a été remarquée. Les analyses des spectres de diffraction aux rayons X aux grands angles, ont confirmé la croissance du taux de cristallinité. En outre les longues périodes calculées, diminuent. Nous avons ainsi vérifié l’apparition de cristallites dans phase amorphe. Par ailleurs un comportement de fragilité continue en fonction du temps et de la température du vieillissement, a été constaté. Les observations au MEB ont révélé la présence d’une importante quantité de particules supposées être des agents nucléants (talc, SiO2, MgO…)For insulating application, AREVA has chosen PET (polyethylene terephthalate) to substitute the epoxy resin as material for insulators in High Voltage Gas Insulated Substation. The main problem of this application is the fact that in operating conditions, the temperature of the PET plates would reach even exceed its glass transition [70°C-80°C]. The material undergoes aging phenomena which affect the temperature-dependent properties. The current investigation aims at observing and analyzing the gradual evolution of the mechanical, morphological and dielectric properties during thermal aging. To reach this goal, semi crystalline PET samples have been aged under vacuum at different temperatures i.e. 60°C, 80°C, 115°C and 125°C for various periods of time (until 12 months). The characterizations have been performed using several techniques: Differential scanning calorimetric (DSC), wide and small angle X-ray scattering (WAXS/SAXS), thermo-mechanical analysis (DMA), tensile test and morphological observation.The DSC measurements show that the crystallinity ratio increases with temperature and time of aging. The glass transition has increased. However no significant changes have been seen on the melting temperature. The DMA results agree with the DSC measurement in so far as it has revealed an expected increase of the Young modulus for all the samples studied. Significant differences have been observed using X-ray scattering: while the crystallinity ratio did increase, the long period has decreased specially for the case of aging at 115 and 125°C. The DMA measurements showed an almost stable glass transition around 80°C but an increase for samples aged at 125°C. When the samples have been subjected to the tensile test, a significant brittleness rise has been noticed. In addition, the SEM has revealed the presence of important amount of nucleant agent (talc, SiO2, MgO …)
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Modaresi, Mahyar. "System and Method for Passive Radiative RFID Tag Positioning in Realtime for both Elevation and Azimuth Directions." Thesis, KTH, Communication Systems, CoS, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-24562.
Full textAbstract:
In this thesis, design and realization of a system which enables precise positioning of RFID tags in both azimuth and elevation angles is explained. The positioning is based on measuring the phase difference between four Yagi antennas placed in two arrays. One array is placed in the azimuth plane and the other array is perpendicular to the first array in the elevation plane. The phase difference of the signals received from the antennas in the azimuth array is used to find the position of RFID tag in the horizontal direction. For the position in the vertical direction, the phase difference of the signals received from the antennas in the elevation plane is used. After that the position of tag in horizontal and vertical directions is used to control the mouse cursor in the horizontal and vertical directions on the computer screen. In this way by attaching one RFID tag to a plastic rod, a wireless pen is implemented which enables drawing in the air by using a program like Paint in Windows. Simulated results show that the resolution of the tag positioning in the system is in the order of 3mm in a distance equal to 0.5 meter in front of the array with few number of averaging over the received phase data. Using the system in practice reveals that it is easily possible to write and draw with this RFID pen. In addition it is argued how the system is totally immune to any counterfeit attempt for faked drawings by randomly changing the transmitting antenna in the array. This will make the system a novel option for human identity verification.
QC 20100920
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Massari, Devis. "Progetto analitico e numerico di antenne miniaturizzate per RF-ID adatta a superfici metalliche." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14196/.
Full textAbstract:
Le attuali tecnologie per la realizzazione di tag RFID UHF prevedono l'uso di un dipolo in microstriscia. Tale soluzione non risulta pienamente efficace in substrati diversi dall'aria e totalmente inutile se il dipolo è applicato su piani di natura metallica.
In questo studio mediante l'ausilio di un software di simulazione elettromagnetica come CST Microwaves Studio, è stato sviluppato il progetto di un'antenna in microstriscia, la quale per natura fisica della stessa, risulta essere molto efficace anche su superfici metalliche.
In seguito sono state scalate le dimensioni adottando un'architettura di tipo P.I.F.A. e incrementato il valore di guadagno e efficienza tramite la realizzazione una ulteriore antenna detta parassita, posta sopra l'antenna originaria, con lunghezza ridotta del 13%.
Infine, ottenuti buoni valori di guadagno, è stata adattata l'impedenza di ingresso dell'antenna, al valore di impedenza del raddrizzatore di tensione tramite circuito adattatore composto da una micrsotriscia meandrizzata ed uno stub cortocircuitato.
L'antenna ottenuta presenta un guadagno pari a 0,805 con una efficienza del 45%. Presenta inoltre dimensioni ridotte rispetto al dipolo originario pari al 30%, e pari al 95% rispetto alla patch di partenza.
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Fiorini, Luca. "Applicazione della Tomografia con raggi X per la lettura virtuale di antichi manoscritti veneziani." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/11428/.
Full textAbstract:
Questo lavoro di tesi si inserisce in un progetto di ricerca internazionale denominato “Venice Time Machine” dove collaborano fianco a fianco l’Ecole Polytechnique Fédérale de Lausanne e l’Università Cà Foscari di Venezia. Grazie al coinvolgimento dell’Archivio di Stato di Venezia, decine di chilometri di documenti verranno digitalizzati e indicizzati, al fine di creare un database open access da utilizzare per la ricerca e l’istruzione. Molti di questi documenti tuttavia sono particolarmente fragili oppure, come nel caso di diversi testamenti, non sono mai stati aperti, per cui le tecniche tradizionali di digitalizzazione non sono applicabili. Di qui deriva l’interesse per sperimentare nuove tecniche non invasive al fine di digitalizzare e quindi rendere fruibili al pubblico anche questi documenti altrimenti inaccessibili.
Lo scopo dell’analisi tomografica è quello di creare un modello 3D del documento, su cui effettuare successive elaborazioni al fine di ottenere una separazione virtuale delle pagine e quindi permetterne la lettura anche se il manoscritto è chiuso e non può essere aperto.
In particolare in questo lavoro di tesi sono stati analizzati due testamenti: un testamento del 1679, usato come campione di prova per verificare la migliore sorgente di raggi X ai fini della ricostruzione tomografica e anche per valutare l’efficacia della tecnica, e il testamento Alchier-Spiera (dai nomi dei testatori), datato 1634, di maggiore interesse poiché ancora chiuso.
I risultati ottenuti sono molto soddisfacenti, poiché elaborando le ricostruzioni tomografiche è possibile la lettura virtuale sia di parole che di intere frasi. Questo risultato porta nuova linfa al progetto che, di base, si pone l’obiettivo di convertire in formato digitale decine di km di testi conservati in Archivio, ma che ha trovato, in questo tipo di testamenti chiusi, un ostacolo molto difficile da superare.