Academic literature on the topic 'Tat imprints'
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Journal articles on the topic "Tat imprints"
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Yusim, Karina, Can Kesmir, Brian Gaschen, Marylyn M. Addo, Marcus Altfeld, Søren Brunak, Alexandre Chigaev, Vincent Detours, and Bette T. Korber. "Clustering Patterns of Cytotoxic T-Lymphocyte Epitopes in Human Immunodeficiency Virus Type 1 (HIV-1) Proteins Reveal Imprints of Immune Evasion on HIV-1 Global Variation." Journal of Virology 76, no. 17 (September 1, 2002): 8757–68. http://dx.doi.org/10.1128/jvi.76.17.8757-8768.2002.
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ABSTRACT The human cytotoxic T-lymphocyte (CTL) response to human immunodeficiency virus type 1 (HIV-1) has been intensely studied, and hundreds of CTL epitopes have been experimentally defined, published, and compiled in the HIV Molecular Immunology Database. Maps of CTL epitopes on HIV-1 protein sequences reveal that defined epitopes tend to cluster. Here we integrate the global sequence and immunology databases to systematically explore the relationship between HIV-1 amino acid sequences and CTL epitope distributions. CTL responses to five HIV-1 proteins, Gag p17, Gag p24, reverse transcriptase (RT), Env, and Nef, have been particularly well characterized in the literature to date. Through comparing CTL epitope distributions in these five proteins to global protein sequence alignments, we identified distinct characteristics of HIV amino acid sequences that correlate with CTL epitope localization. First, experimentally defined HIV CTL epitopes are concentrated in relatively conserved regions. Second, the highly variable regions that lack epitopes bear cumulative evidence of past immune escape that may make them relatively refractive to CTLs: a paucity of predicted proteasome processing sites and an enrichment for amino acids that do not serve as C-terminal anchor residues. Finally, CTL epitopes are more highly concentrated in alpha-helical regions of proteins. Based on amino acid sequence characteristics, in a blinded fashion, we predicted regions in HIV regulatory and accessory proteins that would be likely to contain CTL epitopes; these predictions were then validated by comparison to new sets of experimentally defined epitopes in HIV-1 Rev, Tat, Vif, and Vpr.
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Gouws, T. "Die transkripsielees van T.T. Cloete." Literator 10, no. 3 (May 7, 1989): 31–47. http://dx.doi.org/10.4102/lit.v10i3.834.
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In a transcriptual approach to the literary discourse, the text as artefact is regarded as a creation of the scriptor. The artificiality of the poetics implies conscious or unconscious structuring - Cloete terms it dreamful thinking (“die dromende denke”) - by inevitably exploiting language conventions and the poetic devices, the sole purpose being that the organised composition can be the only (as well as measurable) indication of authorial intention. Likewise, in as far as language presents the relevant possibilities, authorial intention is imprinted upon the textual composition or is transposed lingually. Moreover, a transcriptual reading of Cloete texts has shown clearly that the text as language presentation exhibits a wilfulness, a creative language potency or energy which has to be activated by the reader. This dynamic, significatory potency is not constricted by the authorial intention; rather, it offers a framework within which language may claim to determinate actualisation. Realisation by the reader is therefore nothing more than a transcript of the possibilities and presentation of language. Added to this is the following qualification that this transcriptual process brings about an aesthetically realised object which is the imprint of the reader’s understanding. By reading Cloete’s poetry through transcriptually tinted glasses, the richness of this reading strategy becomes clear.
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Liu, Chen, Zixuan Dong, Li Huang, Wenlong Yan, Xin Wang, Dingyi Fang, and Xiaojiang Chen. "TagSleep3D." Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies 8, no. 1 (March 6, 2024): 1–28. http://dx.doi.org/10.1145/3643512.
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Sleep posture plays a crucial role in maintaining good morpheus quality and overall health. As a result, long-term monitoring of 3D sleep postures is significant for sleep analysis and chronic disease prevention. To recognize sleep postures, traditional methods either use cameras to record image data or require the user to wear wearable devices or sleep on pressure mattresses. However, these methods could raise privacy concerns and cause discomfort during sleep. Accordingly, the RF (Radio Frequency) based method has emerged as a promising alternative. Despite most of these methods achieving high precision in classifying sleep postures, they struggle to retrieve 3D sleep postures due to difficulties in capturing 3D positions of static body joints. In this work, we propose TagSleep3D to resolve all the above issues. Specifically, inspired by the concept of RFID tag sheets, we explore the possibility of recognizing 3D sleep posture by deploying an RFID tag array under the bedsheet. When a user sleeps in bed, the signals of some tags could be blocked or reflected by the sleep posture, which can produce a body imprint. We then propose a novel deep learning model composed of the attention mechanism, convolutional neural network, and together with two data augmentation methods to retrieve the 3D sleep postures by analyzing these body imprints. We evaluate TagSleep3D with 43 users and we totally collect 27,300 sleep posture samples. Our extensive experiments demonstrate that TagSleep3D can recognize each joint on the human skeleton with a median MPJPE (Mean Per Joint Position Error) of 4.76 cm for seen users and 7.58 cm for unseen users.
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Lafuente-González, Elsa, Miriam Guadaño-Sánchez, Idoia Urriza-Arsuaga, and Javier Lucas Urraca. "Core-Shell Magnetic Imprinted Polymers for the Recognition of FLAG-Tagpeptide." International Journal of Molecular Sciences 24, no. 4 (February 9, 2023): 3453. http://dx.doi.org/10.3390/ijms24043453.
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FLAG® tag (DYKDDDDK) is a small epitope peptide employed for the purification of recombinant proteins such as immunoglobulins, cytokines, and gene regulatory proteins. It provides superior purity and recoveries of fused target proteins when compared to the commonly used His-tag. Nevertheless, the immunoaffinity-based adsorbents required for their isolation are far more expensive than the ligand-based affinity resin used in combination with the His-tag. In order to overcome this limitation we report herein the development of molecularly imprinted polymers (MIPs) selective to the FLAG® tag. The polymers were prepared by the epitope imprinting approach using a four amino acids peptide, DYKD, including part of the FLAG® sequence as template molecule. Different kinds of magnetic polymers were synthesised in aqueous and organic media also using different sizes of magnetite core nanoparticles. The synthesised polymers were used as solid phase extraction materials with excellent recoveries and high specificity for both peptides. The magnetic properties of the polymers confer a new, effective, simple, and fast method in the purification using FLAG® tag.
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Hoh, JFY. "Myogenic Regulation of Mammalian Skeletal Muscle Fibres." Physiology 6, no. 1 (February 1, 1991): 1–6. http://dx.doi.org/10.1152/physiologyonline.1991.6.1.1.
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Motor nerves can only modify the phenotype of muscle fibres within a myogenically determined range. The particular range of a given fibre is an intrinsic property of that fibre, depending on the type of muscle (limb or jaw) and the specific tag imprinted upon it during development.
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Balčius, Jonas. "TAUTOS IR TAUTINĖS IŠTIKIMYBĖS PROBLEMA A. MACEINOS IR J. GIRNIAUS VEIKALUOSE." Problemos 73 (January 1, 2008): 179–96. http://dx.doi.org/10.15388/problemos.2008.0.2008.
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Straipsnyje aptariami ir įvertinami Antano Maceinos (1908–1987) ir Juozo Girniaus (1915–1994) veikalai, skirti lietuvių tautos kultūrinio ir politinio išliekamumo klausimams sovietų okupacijos ir tautinės emigracijos sąlygomis. Parodoma, jog šiame darbe cituojami minėtų lietuvių filosofų darbai tebėra vieni reikšmingiausių ir teoriškai brandžiausių veikalų, parašytų ne tik emigracijoje, bet ir per visą Lietuvos filosofijos istoriją. Tai reiškia, kad jie neprarado savo konceptualiojo – teorinio ir praktinio – aktualumo ir mūsų laikais, nes Lietuvos istorija, kaip žinoma, turi didesnių abejonių nekeliančių cikliškumo bruožų – ir tai nėra būdinga vien XX amžiui. Agresyvėjanti dabartinės Rusijos politika – jos strategija ir taktika Baltijos valstybių atžvilgiu rodo, jog minėtuosius pokario laikų lietuvių filosofų, gyvenusių ir dirbusių emigracijos sąlygomis, teorinius veikalus dar pernelyg anksti priskirti tik istorinei lietuvių tautos kovų už savąjį valstybingumą ir laisvę praeičiai. Tai reiškia, tad jie tebeturi ir didesnių abejonių nekeliančio amžinojo šiuolaikiškumo žymę. Pagrindiniai žodžiai: tauta, tautinė ištikimybė, kultūra, moralinė atsakomybė.Nation and National Loyalty in the Works of A. Maceina and J. GirniusJonas Balčius Summary The article focuses on discussing and evaluating works by Antanas Maceina (1908–1987) and Juozas Girnius (1915–1994) dwelling on questions of the cultural and political survival of the Lithuanian nation under harsh conditions of Soviet occupation and NATIONAL emigration. It is demonstrated that works by the Lithuanian philosophers cited here remain among the most significant and theoretically mature contributions not only in the context of emigration, but also in terms of the whole history of Lithuanian philosophy. These works have not lost their conceptual relevance (both in theory and practice) in the modern times as well, because Lithuanian history may be more or less reasonably characterized by certain cyclical traces, and this assertion holds true not only for the 20th century. The increasingly aggressive policy of modern Russia (ruled by the Putin regime), particularly its strategy and tactics in dealing with the Baltic states, clearly indicate it being far too early to attribute these theoretical works by the above mentioned postwar Lithuanian philosophers living and working in the exile to the historical past of the Lithuanian people’s struggle for its national independence and freedom only. On the contrary, this indicates them being undoubtedly marked with the imprint of eternal modernity. Keywords: nation, national loyalty, culture, resistance, moral responsibility.>
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Beezley, William H. "Juan O'Gorman, Daniel Cosío Villegas, and the Mexican Historical Profession: An Interview with Josefina Zoraida Vázquez." Americas 67, no. 2 (October 2010): 253–68. http://dx.doi.org/10.1353/tam.2010.0007.
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Professor Josefina Zoraida Vázquez has made an indelible imprint on the discipline of the history of Mexico. Her publications have provided an analysis of the Mexican experience through such diverse themes as the U.S. invasion (1846-1848), the evolution of national education programs, and the struggles to establish federalism and republicanism in the first decades of independence. She has written official textbooks used by all Mexican school children, appeared on numerous television programs, taught dozens of doctoral students, and assisted many scholars in both Mexico and the United States. She has been an active member of the historical profession; she organized the Congress of Mexican Historians from Mexico, the United States, and Canada in Patzcuaro in 1977 and served as the President of the same organization in Monterrey in 2003.
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Sutton, Margie N., Gilbert Y. Huang, Xiaowen Liang, Rajesh Sharma, Albert S. Reger, Weiqun Mao, Lan Pang, et al. "DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1." Cancers 11, no. 4 (April 18, 2019): 557. http://dx.doi.org/10.3390/cancers11040557.
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Autophagy can protect cancer cells from acute starvation and enhance resistance to chemotherapy. Previously, we reported that autophagy plays a critical role in the survival of dormant, drug resistant ovarian cancer cells using human xenograft models and correlated the up-regulation of autophagy and DIRAS3 expression in clinical samples obtained during “second look” operations. DIRAS3 is an imprinted tumor suppressor gene that encodes a 26 kD GTPase with homology to RAS that inhibits cancer cell proliferation and motility. Re-expression of DIRAS3 in ovarian cancer xenografts also induces dormancy and autophagy. DIRAS3 can bind to Beclin1 forming the Autophagy Initiation Complex that triggers autophagosome formation. Both the N-terminus of DIRAS3 (residues 15–33) and the switch II region of DIRAS3 (residues 93–107) interact directly with BECN1. We have identified an autophagy-inhibiting peptide based on the switch II region of DIRAS3 linked to Tat peptide that is taken up by ovarian cancer cells, binds Beclin1 and inhibits starvation-induced DIRAS3-mediated autophagy.
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Zhu, Shu-Yan, Yuan-Long Li, Kwai-Man Luk, and Stella W. Pang. "Compact High-Gain Si-Imprinted THz Antenna for Ultrahigh Speed Wireless Communications." IEEE Transactions on Antennas and Propagation 68, no. 8 (August 2020): 5945–54. http://dx.doi.org/10.1109/tap.2020.2986863.
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Liu, Jinxin, Xiaoba Wu, Xuefeng Yao, Ronald Yu, Philip J. Larkin, and Chun-Ming Liu. "Mutations in the DNA demethylase OsROS1 result in a thickened aleurone and improved nutritional value in rice grains." Proceedings of the National Academy of Sciences 115, no. 44 (October 1, 2018): 11327–32. http://dx.doi.org/10.1073/pnas.1806304115.
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The rice endosperm, consisting of an outer single-cell layer aleurone and an inner starchy endosperm, is an important staple food for humans. While starchy endosperm stores mainly starch, the aleurone is rich in an array of proteins, vitamins, and minerals. To improve the nutritional value of rice, we screened for mutants with thickened aleurones using a half-seed assay and identified thick aleurone 2–1 (ta2-1), in which the aleurone has 4.8 ± 2.2 cell layers on average. Except for starch, the contents of all measured nutritional factors, including lipids, proteins, vitamins, minerals, and dietary fibers, were increased in ta2-1 grains. Map-based cloning showed that TA2 encodes the DNA demethylase OsROS1. A point mutation in the 14th intron of OsROS1 led to alternative splicing that generated an extra transcript, mOsROS1, with a 21-nt insertion from the intron. Genetic analyses showed that the ta2-1 phenotype is inherited with an unusual gametophytic maternal effect, which is caused not by imprinted gene expression but rather by the presence of the mOsROS1 transcript. Five additional ta2 alleles with the increased aleurone cell layer and different inheritance patterns were identified by TILLING. Genome-wide bisulfite sequencing revealed general increases in CG and CHG methylations in ta2-1 endosperms, along with hypermethylation and reduced expression in two putative aleurone differentiation-related transcription factors. This study thus suggests that OsROS1-mediated DNA demethylation restricts the number of aleurone cell layers in rice and provides a way to improve the nutrition of rice.
Dissertations / Theses on the topic "Tat imprints"
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Hughes, Siobhan Mary. "Genome-wide analysis of proteins that bind to DNA and regulate gene expression, with particular emphasis on imprinted genes." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/genomewide-analysis-of-proteins-that-bind-to-dna-and-regulate-gene-expression-with-particular-emphasis-on-imprinted-genes(4c4ae844-eb4f-40f7-aad3-8d6873f2a85c).html.
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Regulation of gene expression is a complicated process, subject to different mechanisms operating at different levels. At the genomewide level, work in this thesis describes the use of chromatin immunoprecipitation and next-generation sequencing to interrogate the coincident and allele-specific binding of the proteins CTCF, cohesin, ATRX and MeCP2. Identifying regions co-binding these proteins helps generate a model to understand how these proteins influence gene expression, particularly at imprinted loci. Using these tools we are able to understand more about the proteins that participate in the genomic landscape around imprinted loci and drive this unusual mode of gene regulation. These loci act as models for studying DNA binding proteins and their roles in transcription. At the level of the individual locus, mechanisms of gene regulation were investigated using imprinted retrogenes as a model. Retrogenes are transcriptionally active intronless genes located within an intron of a ‘host’ gene. The role of epigenetic factors influencing gene transcription were investigated at the H13/Mcts2 locus. Expression of an intronic retrogene can cause premature termination of a ‘host’ transcript. Our hypothesis is that this premature termination can be caused by transcription of the retrogene interfering with host gene transcription. We have designed a construct based on this locus, which allows us to regulate the expression through the retrogene to study this in more detail. These studies provide a mechanistic component to our whole genome analyses.
Books on the topic "Tat imprints"
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Bakhshiev, D. R. Bibliograficheskĭ spravochnik-ukazatelʹ izdaniĭ na dzhuʹgʹuri, evreĭsko-tatskom i︠a︡zyke gorskikh evreev, za vtorui︠u︡ chetvertʹ XX veka. Moskva: Izdatelʹstvo "TRIUMF", 2017.
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Rossiĭskai͡a nat͡sionalʹnai͡a biblioteka. Otdel literatury na nat͡sionalʹnykh i͡azykakh. Katalog literatury na tatskom yazyke. New York: N. Ross, 1997.
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Xiao, Kezhi. Nong ye gu ji ban ben cong tan. 8th ed. Beijing Shi: Zhongguo nong ye chu ban she, 2007.
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Lan tai wan juan: Du "Han shu yi wen zhi". Beijing Shi: Sheng huo, du shu, xin zhi san lian shu dian, 2011.
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Lu Xun gu ji cang shu man tan. Fuzhou: Fujian jiao yu chu ban she, 2006.
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Zhu, Hangman. Mu tao ji. 8th ed. Shanghai: Wen hui chu ban she, 2019.
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Frederiksen, Erik Ellegaard. Bogstavelig talt: EEF : festskrift til Erik Ellegaard Frederiksen i anledning af hans 70 årsdag 29. april 1994. København: Christian Ejlers f̕orlag, 1994.
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Pan, Jianguo. Gu dai xiao shuo ban ben tan kao. Beijing: Shang wu yin shu guan, 2020.
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Taiwan) Liang an gu ji zheng li xue shu yan tao hui (1996 Taipei. Liang an gu ji zheng li xue shu yan tao hui lun wen ji. 8th ed. [Nanjing shi]: Jiangsu gu chichʻu ban she, 1998.
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Cai tuan fa ren Taiwan Sheng wen hua ji jin hui., ed. Tan xun Fu'ermosha wen hua ban tu: Shen mi mian sha cai feng lu. Nantou Shi: Cai tuan fa ren Taiwan Sheng wen hua ji jin hui, 2003.
Find full textBook chapters on the topic "Tat imprints"
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Mayhew, David R. "After World War II." In The Imprint of Congress. Yale University Press, 2017. http://dx.doi.org/10.12987/yale/9780300215700.003.0006.
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This chapter considers three impulses of the post-World War II era. Two of them deal with the economy, bracketing its course from an inspiration flowing out of the war through an ideological and policy retake a generation later. The other impulse covers one of the major developments of American, not to mention transnational, history—the civil rights revolution of those times. In the three impulses detailed here, economic planning devices, energy supply, the cities, travel, infrastructure, the tax code, industrial structure, the workplace, immigration, demographic patterns, the electorate, rights standards, and relations among the races, gained lasting imprints from U.S. government participation, among others.
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Zelizer, Julian E. "“Where Is the Money Coming From?”1 the Reconstruction of Social Security Finance." In Governing America. Princeton University Press, 2012. http://dx.doi.org/10.23943/princeton/9780691150734.003.0009.
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This chapter examines how Social Security finance was reconstructed in response to actions by Congress, which abolished the mandate for a large reserve and authorized the use of general revenue to pay for benefits when payroll taxes became insufficient. After describing the earmarked tax system created by Congress in 1935, the chapter considers the debate between 1939 and 1948 about the survival of the Social Security tax system and whether Social Security would be financed through the same monies as all other programs. It also looks at a cadre of policymakers, including Wilbur Mills and Robert Myers, who redesigned the earmarked tax system into the structure that defined the program until 1972. It shows that the earmarked tax system left the imprint of fiscal conservatism on Social Security by imposing certain long-term restrictions on the program.
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Karakaya-Stump, Ayfer. "The Iraq Connection: Abu’l-Wafaʾ Taj al-ʿArifin and the Wafaʾi Tradition." In The Kizilbash-Alevis in Ottoman Anatolia, 44–88. Edinburgh University Press, 2019. http://dx.doi.org/10.3366/edinburgh/9781474432689.003.0002.
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In the oldest cluster of the recently surfaced Kizilbash/Alevi documents(mainly Sufi diplomas (ijāzas) and genealogies (shajaras), or fragments thereof(Abu’l-Wafaʾ Taj al-ʿArifin, the eponym of the Wafaʾi order, is frequently named as a familial and/or spiritual progenitor. The story of the Wafaʾiyya, which one rarely encounters in histories of Islamic mysticism, began in eleventh-century Iraq, but its Iraqi branch seems to have faded away over a few generations, leaving behind no permanent imprints. Chapters 1 and 2 address the implications of the historical affinity of some of the most prominent Alevi saintly lineages with the Wafaʾi Sufi tradition. Chapter 1 presents a selective overview of the life and spiritual legacy of Abu’l-Wafaʾ, based on the hagiography of the saint and other near-contemporary Sufi narratives. It underlines the difficulty of categorizing the saint and his spiritual legacy along the lines of conventional binaries of Sunni versus Shiʿi and “heterodox” versus “orthodox.” This chapter makes the point that the metadoxic outlook of the Babaʾi milieu in medieval Anatolia, as well as many components of Kizilbashism-Alevism, explained on the basis of pre-Islamic survivals in the conventional literature, in fact had their parallels and antecedents in the early Wafaʾi milieu.
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Emerson, Michael Oluf, and Kevin T. Smiley. "How Government and Leaders Make Cities Work." In Market Cities, People Cities. NYU Press, 2018. http://dx.doi.org/10.18574/nyu/9781479856794.003.0003.
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Chapter 3 discusses government in the two cities in four sections. First, we do not take for granted what government is supposed to do but instead analyze how leaders consider the role of government in the first place. Second, we discuss the priorities that rank highest on their priorities rubric for the government. Third, we discuss how they pay for city services by examining budgets and tax structures. Finally, we look outside government to see how much of what is public is accomplished by nongovernmental actors, especially in Market Cities. Through all of these, we show how Copenhagen has a much wider and collective imprint on what government should do than does the Market City of Houston.
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Haberly, Daniel, and Dariusz Wójcik. "Regional Blocks and Imperial Legacies." In Sticky Power, 210–35. Oxford University Press, 2022. http://dx.doi.org/10.1093/oso/9780198870982.003.0007.
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While foreign direct investment (FDI) is generally assumed to represent long-term investments within the real economy, approximately half of global FDI is accounted for by networks of offshore shell companies created by corporations and individuals for tax and other purposes. Important empirical as well as conceptual questions surround both the global structure, and the significance of these networks. This chapter seeks to answer these questions by employing principal component analysis to decompose the global bilateral FDI anomaly matrix into its primary constituent subnetworks. It finds that the global offshore FDI network is highly globalized, with a centralized core of jurisdictions in Northwest Europe and the Caribbean exercising a largely homogeneous worldwide influence. To the extent that the network is internally differentiated, this appears to primarily reflect a historic layering of social and political relationships. Four primary offshore FDI subnetworks are identified, bearing the imprint of four key processes and events: European, particularly UK colonialism, the post–WWII hegemonic alliance between the United States and Western Europe, the fall of Soviet communism, and the rise of Chinese capitalism. Evidence is also found of qualitative, more than quantitative variation in offshore FDI based on national rule of law and communist history.
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Wohl, Ellen. "October: Of Beavers and Humans." In Saving the Dammed. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190943523.003.0013.
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By mid-October, the first snow has fallen on the beaver meadow. There is no sign of snow when I visit a few days later, but the air feels chill in the shadows and a cool breeze leavens the sunshine’s warmth. Mostly, the beaver meadow seems a golden place. Many of the willow, aspen, and birch leaves have already fallen, but enough remain to create a glowing ménage of yellow, gold, palest orange, and tan. Each leaf refracts and filters the light so that it comes from every direction rather than only from above. Aspens on the north-facing valley slope stand bare and pale gray. Those on the south facing slope form bursts of gold among the dark green conifers. The beaver meadow remains lively with activity. Dance flies move upward and downward in a column of air backlit by sunshine, their delicate bodies shimmering in the low-angle light. A little black stonefly lands on the back of my hand. I resist the urge, bred by summer mosquitoes, to reflexively slap it away. As I cross smaller side channels, brook trout dart away from the warm shallows where they have been resting. The narrow band of white on each dorsal fin flashes as the fish moves swiftly toward deeper water. When one small trout gets momentarily stuck between two exposed cobbles, I cup its slender, wriggling body between my hands and help it along. Windrows of fallen leaves form swirling patterns on the water surface and streambed. Filamentous algae grow in thick green strands along the side channels, where lower water exposes wide bands of mud along the channel edges. The mud bands record the comings and goings along the channel: precise imprints of raccoon feet and deer hooves and blurrier outlines left by moose. Moose beds mat down the tall grasses scattered among the willow thickets. As usual, the beavers themselves elude me, but I see fresh mud and neatly peeled white branches with gnawed ends on some of the dams. Lower water in the beaver pond exposes an entrance hole in the side of the lodge.
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Wohl, Ellen. "August: Legacy Effects." In Saving the Dammed. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190943523.003.0011.
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Emily Dickinson wrote a lovely poem using a brook as a metaphor for one’s interior life. The poem includes the lines: . . . And later, in August it may be, When the meadows parching lie, Beware lest this little brook of life Some burning noon go dry! . . . No chance of the little brook going dry if it runs through a beaver meadow. The movement of water across and through the North St. Vrain beaver meadow has slowed perceptibly by August. Some of the secondary channels barely flow and the main channel is easily crossed on foot. The water remains high in the main beaver pond, but few of the small dams winding across the meadow have water spilling over them. My feet are less likely to sink into wet black muck as I wander through the meadow, and even the moose tracks leave less of an imprint in the drying soil. Plenty of water remains, however, and the meadow is a much brighter shade of green than the adjacent, drier hill slopes. Many flowers remain in bloom across the meadow. Stalks bristling with the elaborate, richly pink blossoms of elephant’s head rise above standing water. Dusky purple monkshood flowers in slightly drier soil, as do the showy blue and white columbines. The blue bell-shaped flowers of harebell mark the driest sites. The late-summer flowers are joined now by the spreading tan or scarlet caps of fungi, as well as green berries on the ground juniper and kinnikinnick growing on the drier terrace beside the beaver meadow. Songbirds born this summer are fully feathered and capable fliers, and some of the birds have already left the meadow for the year. Early morning temperatures carry a hint of the coming autumn. The beaver kits grow steadily more capable, too, and by now they are used to foraging on their own. Presumably, this frees the breeding adult female for more time spent in dam and lodge repair or starting the food cache for the coming winter.
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Hauser, Kitty. "Revenants in the Landscape: The Discoveries of Aerial Photography." In Shadow Sites. Oxford University Press, 2007. http://dx.doi.org/10.1093/oso/9780199206322.003.0009.
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In 1937 John Piper’s article ‘Prehistory from the Air’ was published in the final volume of the modernist art journal Axis. In it, Piper compares the landscapes of southern England, seen from above, with the modernist works of Miró and Picasso (Fig. 4.1). His interest in the aerial view is not, however, confined to its Formalist-aesthetic aspect; Piper also points out how flying and aerial photography have accelerated archaeological theory and practice. Aerial photographs, he writes, ‘have elucidated known sites of earthworks and have shown the sites of many that were previously unknown’. They are also, he continues, ‘among the most beautiful photographs ever taken’. The aerial view, it seems, could be both investigative and aesthetic. The use of aerial photography by archaeologists, known as ‘aerial archaeology’, began in earnest in Britain in the decade in which Piper was writing, although its possibilities were beginning to be suspected in the 1920s, after the use of aerial photography for reconnaissance purposes in the First World War. In the interwar period it was British archaeologists who pioneered the new methods of aerial archaeology. In his book on aerial archaeology, Leo Deuel notes that until the 1950s ‘no other European country had made any comparable effort to tap the almost limitless store of information consecutive cultures had imprinted on its soil’. As many commentators pointed out, the British landscape offered plenty of such ‘information’: the series of invasions, settlements, clearances, and developments that constitute British history have made the landscape a veritable palimpsest, the layers of which can potentially be revealed in an aerial view. Archaeologists became expert in deciphering aerial views of this palimpsest, as we shall see. But such views of Britain exercised an appeal beyond archaeological circles. Aerial photography showed Britain as it had never before been seen; it revealed aspects of the landscape hitherto unknown, or at least never before visualized in such concrete form. The aerial view ‘made strange’ long-familiar features: hills seemed to disappear, towns and cities might appear tiny, rivers and roads ran through the two-dimensional scene like veins.
Conference papers on the topic "Tat imprints"
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Li, Guoqiang, and Ephraim J. Gutmark. "Experimental and Numerical Studies of the Velocity Field of a Triple Annular Swirler." In ASME Turbo Expo 2002: Power for Land, Sea, and Air. ASMEDC, 2002. http://dx.doi.org/10.1115/gt2002-30069.
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Modern industrial gas-turbine spray combustors feature multiple swirlers and distributed fuel injection for rapid mixing and stabilization. The present paper is the first of a sequence of papers that aim to study the flow field of such combustors, the related combustion characteristics and their control. The present paper focuses on an experimental investigation of the velocity flow field downstream of a Triple Annular Swirler (TAS) and CFD description of the flow field inside the TAS. Multiple combinations of swirlers of various swirl level and rotational direction were tested in cold flow under atmospheric conditions without a confining combustion chamber. The experiments showed that a Central Toroidal Recirculation Zone (CTRZ) and an annular jet with internal and external shear layers characterize the flow field downstream of TAS. The CTRZ is axisymmetric but the jet contains imprints of the internal flow and has some nonaxisymmetric features. Numerical RANS results confirmed these observations and showed that the asymmetry relates to the effect of the internal swirling vanes on the jet flow.
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Camatti, Anne Caroline, Yasmim Colares Patriota de Souza, Priscilla Cardoso Alves, Lucas Marlon Freiria, and Marcy Lancia Pereira. "Tumor venéreo transmissível resistente a vincristina e doxorrubicina." In Semana Online Científica de Veterinária. CONGRESSE.ME, 2021. http://dx.doi.org/10.54265/eucq8237.
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Introdução: O tumor venéreo transmissível (TVT) é uma das neoplasias mais comuns em cães e acomete principalmente a mucosa genital externa. É caracterizado como uma neoplasia de células redondas, altamente contagioso e sua transmissão ocorre pela implantação de tecido tumoral durante coito, brigas ou durante a interações entre animais portadores. O diagnóstico se baseia no histórico, exame físico geral e é confirmado por meio de exames de citologia por aspiração ou imprint tecidual ou pelo exame histopatológico. Quanto ao tratamento, pode-se optar por cirurgia, criocirurgia, eletroquimioterapia, radioterapia ou quimioterapia citotóxica, sendo a monoterapia com sulfato de vincristina o protocolo terapêutico mais utilizado. Objetivo: Este trabalho tem como objetivo relatar o caso de um cão com TVT peniano resistente ao sulfato de vincristina e cloridato de doxorrubicina. Métodos: Para tal, foram colhidas informações do prontuário e os protocolos quimioterápicos empregados. Resultados: Um cão macho não castrado, adulto jovem, sem raça definida e que convive com outros três cães, deu entrada na Clínica veterinária Escola da Universidade Federal de Santa Catarina, campus Curitibanos, com a queixa de sangramento peniano há aproximadamente dois meses. O paciente apresentava nódulos com aspecto rugoso no bulbo da glande, que mediam cerca de 3 e 2 mm de diâmetro. O diagnóstico foi estabelecido por meio da citologia por imprint, que confirmou o TVT. Foi iniciado tratamento com vincristina endovenosa por quatro sessões semanais com dose de 0,50 mg/m². O sangramento peniano cessou após a 2ª sessão. A dose foi aumentada para 0,75 mg/m² a partir da 5ª sessão, pois os tumores pararam de regredir. Finalizada a 6ª sessão, foi instituído protocolo com doxorrubicina endovenosa a 30 mg/m² em duas sessões de intervalo trissemanal, mas novamente os nódulos regrediram sem remissão total. Conclusão: A terapia quimioterápica isolada ou associada costuma desencadear boa resposta no tratamento do TVT, em que normalmente se observa remissão total com sulfato de vincristina, tida como terapêutica de escolha. Entretanto, ocorre ineficácia em casos de resistência, casos incomuns como o do canino em questão. A quimiorresistência pode estar associada ao tipo citológico do tumor ou à superexpressão da glicoproteína-P pelas células tumorais, uma molécula capaz de atuar no efluxo da droga. Nos casos de resistência a quimioterápicos, podem ser empregados outros agentes medicamentosos como cliclosfosfamida, sulfato de vimblastina e metrotexato, já que o cloridrato de doxorrubicina apenas reduziu o tamanho dos nódulos. A radiação é uma terapia efetiva com prognóstico favorável e bons resultados nos tumores extensos, localizados e/ou resistentes à vincristina. O uso de eletroquimioterapia se destaca pela eficácia em relação à quimioterapia tradicional no tratamento de tumores quimio resistentes. A excisão cirúrgica não seria recomendada devido à alta taxa de recidiva, pois durante o procedimento cirúrgico pode ocorrer transplantação de células neoplásicas no local da cirurgia ou em outros sítios. PALAVRAS-CHAVE: Canino, Neoplasia, Oncologia, Quimioterapia
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Gomes, Artur Bruno Silva, Felipe Jatobá Nonato de Sá, Juliana Matos Ferreira Bernardo, and Carlos Daniel Passos Lobo. "ABORDAGEM DIAGNÓSTICA LABORATORIAL NA LEISHMANIOSE." In I Congresso Brasileiro de Parasitologia Humana On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/751.
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Introdução: Antropozoonose causada pelo protozoário intracelular do gênero Leishmania é transmitida pela picada de flebotomíneos. O espectro das manifestações clínicas varia de úlcera cutânea autolimitada, à doença mucocutânea e às apresentações sistêmicas. Assim, a abordagem diagnóstica é precedida pela clínica e história epidemiológica, e a evidência do parasita obtida por esfregaço da lesão, biópsia e testes imunológicos. Objetivo: Elucidar os métodos diagnósticos para leishmaniose. Material e Métodos: Revisão bibliográfica integrativa, realizada no portal eletrônico PUBMED. Utilizou-se como estratégia de busca os descritores: “leishmaniasis” “laboratory diagnosis” “PCR”, combinado pelo operador booleano AND. Como critério de inclusão, elegeram-se filtros de versão 5 anos, trabalhos em modelos humanos e sem restrição linguística, enquanto critério de exclusão, descartaram-se artigos que não abrangeram o recorte de análise. As pesquisas retornaram 145 resultados, após interpretação dos títulos e resumos, selecionaram-se 16 trabalhos. Resultados: Exames laboratoriais classificam-se em parasitológico, biópsia e imunológico. O primeiro, é evidenciado mediante a coleta de material de úlcera ou aspiração de nódulo flutuante mais coloração específica, em que se pesquisa a forma amastigota em esfregaço. A biópsia por imprint de fragmentos de tecido, conduzidos para análise histopatológica, evidenciam os parasitas em macrófagos e infiltrado celular, por vezes, associada à imunohistoquímica. Em seguida, os imunológicos divididos em intradermorreação de montenegro, um teste intradérmico, o qual é positivo em doença ativa e após a cura; sorologia por imunofluorescência, realizada no soro do paciente e o ensaio imunoenzimático. A nova perspectiva ao diagnóstico da leishmaniose, a Reação em Cadeia da Polimerase (PCR) amplifica seletivamente o DNA, permitindo detectar, quantificar e identificar as espécies do parasita, melhorando o diagnóstico molecular. Apresenta versatilidade, tendo em vista a realização em amplas amostras clínicas, assim como não possibilita reações cruzadas ou fornece resultado negativo nas primeiras semanas de infecção como nos métodos imunológicos, além de não ser invasiva tal qual a biópsia. Conclusão: PCR coloca-se como nova abordagem, pois mesmo que apresente alto custo, demonstra maior especificidade e sensibilidade entre os estudos. Além disso, proporciona monitoramento terapêutico e estudos epidemiológicos, no intuito de esclarecer a função de genes, favorecendo aprimoramento e eficiência do método, tal como o diagnóstico precoce.
Reports on the topic "Tat imprints"
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Mitchell, Diane K., Brooke Abounader, Shanell Henry, and Asisat Animashaun. A Procedure for Collecting Mental Workload Data During an Experiment That Is Comparable to IMPRINT Workload Data. Fort Belvoir, VA: Defense Technical Information Center, October 2009. http://dx.doi.org/10.21236/ada626356.
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Fader, G. B. J., R. O. Miller, and B. J. Todd. Unusual features in Halifax Harbour, Nova Scotia, Canada, Part 1. Natural Resources Canada/CMSS/Information Management, 2023. http://dx.doi.org/10.4095/331503.
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The seabed of Halifax Harbour contains a variety of features that can be classified into natural and anthropogenic features. Natural features are formed by nature and consist of bedforms such as sand waves, sedimentary furrows, boulder berms, moraines, pockmarks, etc. Anthropogenic features are those formed by human activity and include anchor marks, cables, shipwrecks, dredge spoils, bridge and dock remains, etc. The anthropogenic imprint on the Harbour bottom is very dense, particularly in the inner Harbour, and makes the collection of natural unaffected seabed samples difficult. This poster illustrates and describes boulder berms, dredged areas and spoils, spud can marks, mining pits, and enigmatic gravel circles.
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Fader, G. B. J., R. O. Miller, and B. J. Todd. Unusual features in Halifax Harbour, Nova Scotia, Canada, part 2. Natural Resources Canada/CMSS/Information Management, 2023. http://dx.doi.org/10.4095/331505.
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The seabed of Halifax Harbour contains a number of features that can be classified into natural and anthropogenic features. Natural features are formed by nature and consist of bedforms such as sand waves, sedimentary furrows, boulder berms, moraines, pockmarks, etc. Anthropogenic features are those formed by human activity and include anchor marks, cables, shipwrecks, dredge spoils, bridge and dock remains. The anthropogenic imprint on the Harbour bottom is very dense, particularly in the inner Harbour, and makes the collection of natural unaffected samples difficult. This poster illustrates and describes anchor marks, gassy sediments, sedimentary furrows, pockmarks, the remnants of submarine net emplacements, vehicles dumped on the seabed, and an area of seafloor rich in glass bottles.
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Lippman, Betsy, Rebecca Sutton, Allyson Doby, Zeynep Ilkkursun, Gulsah Kurt, Shaffa Hameed, Ceren Acarturk, and Brigitte Rohwerder. Covid-19: Understanding the Impact of the Pandemic on Forcibly Displaced Persons. Institute of Development Studies (IDS), January 2022. http://dx.doi.org/10.19088/cc.2021.010.
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The Covid-19 pandemic has left no corner of the world untouched. To cite just one figure, 100 million people have been pushed into poverty, according to a recent World Bank study. The two-speed recovery from the pandemic, depending on vaccine availability, is expected to leave lasting imprints on the economic performances of countries, which data suggest will have a disproportionate effect on forcibly displaced persons and their host communities. This summary highlights key messages from research focusing on how people displaced by war and conflict have been affected by Covid 19 and its secondary impacts. Diverse lived experiences are explored, ranging from the erosion of forcibly displaced persons’ rights during the pandemic, to Syrian refugees with disabilities in Turkey, to displaced Rohingya in Bangladesh. This Research for Policy and Practice Paper sets out examples of the multidimensional social and economic challenges displaced people are facing during the pandemic and presents a series of evidence-based recommendations for positive change that could be achieved even in the most challenging contexts.
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Ohad, Nir, and Robert Fischer. Regulation of plant development by polycomb group proteins. United States Department of Agriculture, January 2008. http://dx.doi.org/10.32747/2008.7695858.bard.
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Our genetic and molecular studies have indicated that FIE a WD-repeat Polycomb group (PcG) protein takes part in multi-component protein complexes. We have shown that FIE PcG protein represses inappropriate programs of development during the reproductive and vegetative phases of the Arabidopsis life cycle. Moreover, we have shown that FIE represses the expression of key regulatory genes that promote flowering (AG and LFY), embryogenesis (LEC1), and shoot formation (KNAT1). These results suggest that the FIE PcG protein participates in the formation of distinct PcG complexes that repress inappropriate gene expression at different stages of plant development. PcG complexes modulate chromatin compactness by modifying histones and thereby regulate gene expression and imprinting. The main goals of our original project were to elucidate the biological functions of PcG proteins, and to understand the molecular mechanisms used by FIE PcG complexes to repress the expression of its gene targets. Our results show that the PcG complex acts within the central cell of the female gametophyte to maintain silencing of MEA paternal allele. Further more we uncovered a novel example of self-imprinting mechanism by the PgG complex. Based on results obtained in the cures of our research program we extended our proposed goals and elucidated the role of DME in regulating plant gene imprinting. We discovered that in addition to MEA,DME also imprints two other genes, FWA and FIS2. Activation of FWA and FIS2 coincides with a reduction in 5-methylcytosine in their respective promoters. Since endosperm is a terminally differentiated tissue, the methylation status in the FWA and FIS2 promoters does not need to be reestablished in the following generation. We proposed a “One-Way Control” model to highlight differences between plant and animal genomic imprinting. Thus we conclude that DEMETER is a master regulator of plant gene imprinting. Future studies of DME function will elucidate its role in processes and disease where DNA methylation has a key regulatory role both in plants and animals. Such information will provide valuable insight into developing novel strategies to control and improve agricultural traits and overcome particular human diseases.
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Ohad, Nir, and Robert Fischer. Control of Fertilization-Independent Development by the FIE1 Gene. United States Department of Agriculture, August 2000. http://dx.doi.org/10.32747/2000.7575290.bard.
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A fundamental problem in biology is to understand how fertilization initiates reproductive development. During plant reproduction, one sperm cell fuses with the egg to form an embryo, whereas a second sperm cell fuses with the adjacent central cell nucleus to form the endosperm tissue that supports embryo and/or seedling development. To understand the mechanisms that initiate reproduction, we have isolated mutants of Arabidopsis that allow for replication of the central cell and subsequent endosperm development without fertilization. In this project we have cloned the MEA gene and showed that it encode a SET- domain polycomb protein. Such proteins are known to form chromatin-protein complexes that repress homeotic gene transcription and influence cell proliferation from Drosophylla to mammals. We propose a model whereby MEA and an additional polycomb protein we have cloned, FIE , function to suppress a critical aspect of early plant reproduction and endosperm development, until fertilization occurs. Using a molecular approach we were able to determine that FIE and MEA interact physically, suggesting that these proteins have been conserved also during the evolution of flowering plants. The analysis of MEA expression pattern revealed that it is an imprinted gene that displays parent-of- origin-dependent monoallelic expression specifically in the endosperm tissue. Silencing of the paternal MEA allele in the endosperm and the phenotype of mutant mea seeds support the parental conflict theory for the evolution of imprinting in plants and mammals. These results contribute new information on the initiation of endosperm development and provide a unique entry point to study asexual reproduction and apomixis which is expected to improve crop production.
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Bendikov, Michael, and Thomas C. Harmon. Development of Agricultural Sensors Based on Conductive Polymers. United States Department of Agriculture, August 2006. http://dx.doi.org/10.32747/2006.7591738.bard.
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In this 1-year feasibility study, we tried polymerization of several different monomers, commercial as well as novel, specially designed and synthesized for this project in the presence of the nitrate ion to produce imprinted conductive polymers. Polymers 1 and 2 (shown below) produced a response to nitrate, but one inferior to that produced by a polypyrrole (Ppy)-based sensor (which we demonstrated prior to this study). Thus, we elected to proceed with improving the stability of the Ppy-based sensor. In order to improve stability of the Ppy-based sensor, we created a two-layer design which includes nitrate-doped Ppy as an inner layer, and nitrate-doped PEDOT as the outer layer. PEDOT is known for its high environmental stability and conductivity. This design has demonstrated promise, but is still undergoing optimization and stability testing. Previously we had failed to create nitrate-doped PEDOT in the absence of a Ppy layer. Nitrate-doped PEDOT should be very promising for sensor applications due to its high stability and exceptional sensing properties as we showed previously for sensing of perchlorate ions (by perchlorate-doped PEDOT). During this year, we have succeeded in preparing nitrate-doped PEDOT (4 below) by designing a new starting monomer (compound 3 below) for polymerization. We are currently testing this design for nitrate sensing. In parallel with the fabrication design studies, we fabricated and tested nitrate-doped Ppy sensors in a series of flow studies under laboratory and field conditions. Nitrate-doped Ppy sensors are less stable than is desirable but provide excellent nitrate sensing characteristics for the short-term experiments focusing on packaging and deployment strategies. The fabricated sensors were successfully interfaced with a commercial battery-powered self-logging (Onset Computer Hobo Datalogger) and a wireless data acquisition and transmission system (Crossbow Technologies MDA300 sensor interface and Mica2 wireless mote). In a series of flow-through experiments with water, the nitrate-doped Ppy sensors were exposed to pulses of dissolved nitrate and compared favorably with an expensive commercial sensor. In 24-hour field tests in both Merced and in Palmdale, CA agricultural soils, the sensors responded to introduced nitrate pulses, but with different dynamics relative to the larger commercial sensors. These experiments are on-going but suggest a form factor (size, shape) effect of the sensor when deployed in a porous medium such as soil. To fill the need for a miniature reference electrode, we identified and tested one commercial version (Cypress Systems, ESA Mini-reference electrode) which works well but is expensive ($190). To create an inexpensive miniature reference electrode, we are exploring the use of AgCl-coated silver wire. This electrode is not a “true” reference electrode; however, it can calibrated once versus a commercial reference electrode at the time of deployment in soil. Thus, only one commercial reference electrode would suffice to support a multiple sensor deployment.
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Indigenous presence in Bolvian Folk Art: Folk Art in Bolivia: Celebration of Everyday Life. Inter-American Development Bank, November 2004. http://dx.doi.org/10.18235/0006412.
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Bolivian folk art is created in both urban and rural areas, and like the people of Bolivia themselves, it bears a strong indigenous imprint. Many contemporary works owe their current form to lengthy cultural processes over centuries, during which time local materials were worked, forms took shape, color codes were chosen, and iconographies defined. This cultural treasure is transmitted from generation to generation, and comprises a whole that brings us close to the aesthetic and symbolic world of cultures of the past and the present. Understanding the folk art produced in Bolivia today requires situating it in its cultural context and tracing its evolution through history. In other words, the whole in this case is greater than the sum of its parts: folk art objects are very much manifestations of the broader cultural developments from which they arise.