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Journal articles on the topic 'Targeted Assessment'

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Published: 4 June 2021
Last updated: 1 February 2022

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1

Barner, Robert. "The targeted assessment coaching interview." Career Development International 11, no. 2 (February 2006): 96–107. http://dx.doi.org/10.1108/13620430610651868.

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2

Hou, Cindy, Shannon Davila, Mary Miller, Ashlee Hiester, Katherine Hosmer, and LaKisha Kelley. "Targeted Assessment for Prevention: A Statewide Collaborative." Infection Control & Hospital Epidemiology 41, S1 (October 2020): s401. http://dx.doi.org/10.1017/ice.2020.1047.

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Background: Infection preventionists (IPs) are the backbone of the quality and safety matrix of their organizations. Tools to help locate potential gaps can provide unique viewpoints from frontline staff. The CDC provides a Targeted Assessment for Prevention (TAP) strategy that identifies vulnerabilities in the prevention of healthcare-associated infection (HAIs). Methods: A statewide quality improvement organization, partnering with the CDC TAP team, administered TAP facility assessments for catheter-associated urinary tract infection (CAUTI), central-line–associated bloodstream infection (CLABSI), and Clostridioides difficile infection (CDI) to a collaborative of 15 acute-care and 2 long-term acute hospitals. More than 800 respondents filled out surveys based on their individualized perceptions of infection prevention practices. Results: The survey results yielded the following lagging indicators: lack of awareness of nursing and physician champions, need for competency-based training of clinical equipment, and feedback on device utilization. At the hospital system level, one improvement team focused on CDI, uncovered leading and lagging areas in general infrastructure, antibiotic stewardship, early detection and appropriate testing, contact precautions, and environmental cleaning. To culminate the TAP collaborative, the cohort of organizations, supported by interdisciplinary teams, participated in a full-day TAP workshop in which they reviewed detailed analyses of their HAI data and assessment results, shared best practices for infection prevention and planned for specific improvement projects using the plan-do-study-act model. Conclusions: Results of a statewide analysis of HAI prevention data and opportunities at a local level were reviewed. The TAP strategy can be used to target opportunities for improvement, to assess gaps in practice, and to develop and implement interventions for improving outcomes. Healthcare facilities and quality improvement organizations can drive infection prevention actions.Funding: NoneDisclosures: None
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3

Schondorf, R. S. "The Targeted Killings Judgment: A Preliminary Assessment." Journal of International Criminal Justice 5, no. 2 (April 19, 2007): 301–9. http://dx.doi.org/10.1093/jicj/mqm009.

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4

O'Connor, Victoria, Yuko Kitagawa, Alexander Stojadinovic, and Anton J. Bilchik. "Targeted lymph node assessment in gastrointestinal neoplasms." Current Problems in Surgery 51, no. 1 (January 2014): 9–37. http://dx.doi.org/10.1067/j.cpsurg.2013.09.001.

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5

Christian, Cary. "Enhanced enforcement outcomes through a responsive regulation approach to sales tax enforcement." Journal of Public Budgeting, Accounting & Financial Management 29, no. 4 (March 1, 2017): 464–97. http://dx.doi.org/10.1108/jpbafm-29-04-2017-b002.

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AbstractIn this study, targeted interventions were applied in a natural quasi-experimental setting to taxpayers engaged in sales tax theft and evasion to gauge both the direct and indirect impacts of a responsive regulation approach to compliance enforcement. The approach adopted included substantial engagement with targeted businesses and deferral of more punishing forms of deterrence based on the target's level of cooperation and effort to return to and maintain compliance. Results were was found to be 2.17:1. Additionally, the impact of the targeted responsive regulation interventions greatly exceeded the results obtained in deterrence-only control groups in terms of tax assessments compared to multiple control groups to determine the indirect impact of the interventions and to compare the responsive regulation approach to traditional deterrence-only enforcement results. The indirect versus direct impact of the targeted responsive regulation enforcement regimen overall and assessment per dollar of cost ($322.19 vs. $5.21).
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Feijtel, Tom, Geert Boeije, Mike Comber, Watze de Wolf, Martin Holt, Volker Koch, Andre Lecloux, and Angela Siebel-Sauer. "THE ECETOC APPROACH TO TARGETED ENVIRONMENTAL RISK ASSESSMENT." Environmental Toxicology and Chemistry 24, no. 2 (2005): 251. http://dx.doi.org/10.1897/04-134.1.

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7

Tam, Greta. "Needs Assessment for a Targeted Health Promotion Campaign." Disaster Medicine and Public Health Preparedness 13, no. 3 (October 2, 2018): 596–604. http://dx.doi.org/10.1017/dmp.2018.97.

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ABSTRACTSince the first human A/H7N9 infection in Hong Kong, there has been an ongoing threat of human-to-human transmission, potentially causing a pandemic. Because there is no vaccine for A/H7N9, the individual preventive measures become all the more important for reducing transmission. However, due to the ongoing threat of numerous avian influenza viruses, the public may suffer from pandemic-media-fatigue. This study was done to assess the need for a targeted A/H7N9 health promotion campaign. Steven and Gillam’s framework using epidemiological, comparative, and corporate approaches was used to assess the need for a targeted A/H7N9 health promotion campaign.Local surveillance data showed that Hong Kong faces a double burden of increasing seasonal influenza activity and threat of an avian influenza pandemic. Experts warned of potential severity and difficulties in A/H7N9 control. In contrast, surveys showed that the Hong Kong public were suffering from pandemic-media-fatigue, lacked anxiety, had misconceptions, and were not vigilant in preventive practices. This was more evident in certain demographics. Content analysis showed that health promotion materials were not targeted or tailored in countries with human A/H7N9 cases. Targeted health promotion campaigns and framing the issue to increase public and media awareness are crucial in preventing the current pandemic-media-fatigue. (Disaster Med Public Health Preparedness.2019;13:596-604)
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8

Finifter, David H., Christine J. Jensen, Carol E. Wilson, and Bryan L. Koenig. "A Comprehensive, Multitiered, Targeted Community Needs Assessment Model." Family & Community Health 28, no. 4 (October 2005): 293–306. http://dx.doi.org/10.1097/00003727-200510000-00003.

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9

Vossekuil, Bryan, Robert A. Fein, and John M. Berglund. "Threat assessment: Assessing the risk of targeted violence." Journal of Threat Assessment and Management 2, no. 3-4 (September 2015): 243–54. http://dx.doi.org/10.1037/tam0000055.

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10

Greene, Mairead, and Paula Shorter. "Conceptual Understanding Weighting System: a targeted assessment tool." Teaching Mathematics and its Applications: An International Journal of the IMA 36, no. 1 (April 28, 2016): 1–17. http://dx.doi.org/10.1093/teamat/hrw003.

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11

Brown, Elizabeth, and Daryl Greaves. "Honing assessment skills to provide well targeted intervention." Australian Journal of Learning Disabilities 6, no. 2 (June 2001): 17–25. http://dx.doi.org/10.1080/19404150109546664.

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12

Schuur, Gerlienke. "Improving chemical risk assessment through tiered and targeted application of exposure assessment." Toxicology Letters 258 (September 2016): S40. http://dx.doi.org/10.1016/j.toxlet.2016.06.1246.

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13

Yang, Xuexue. "Assessment accommodations for emergent bilinguals in mainstream classroom assessments: a targeted literature review." International Multilingual Research Journal 14, no. 3 (October 29, 2019): 217–32. http://dx.doi.org/10.1080/19313152.2019.1681615.

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14

Tunbridge, Michael, David Dickinson, and Pauline Swan. "Trainee psychiatrists' assessment outcomes." Psychiatric Bulletin 28, no. 4 (April 2004): 123–25. http://dx.doi.org/10.1192/pb.28.4.123.

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Aims and MethodThe Record of In-Training Assessment grades of all registrars in the psychiatric specialties in the UK were analysed for each of three successive years, specialty by specialty, and compared with the average outcome for registrars in all disciplines over the same period.ResultsOver 98% of psychiatry registrars were assessed as satisfactory, 1.2% needed targeted training and 0.7% were graded as unsatisfactory, requiring repeat training. Targeted training and repeat training led to a satisfactory outcome in the majority of cases.Clinical ImplicationsThe process of assessment needs to become more objective, and should do so as the Royal Colleges develop better measures of clinical competence.
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15

Davis, Susan, Amanda Tan, and Robin Bell. "Targeted assessment of fracture risk in women at midlife." Maturitas 81, no. 1 (May 2015): 130. http://dx.doi.org/10.1016/j.maturitas.2015.02.098.

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16

Venes, Joan, and Robert Dauser. "Targeted Studies as a Learning Tool in Outcomes Assessment." Surgical Neurology 49, no. 6 (June 1998): 655–59. http://dx.doi.org/10.1016/s0090-3019(97)00460-6.

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17

Sood, Anil K., and Robert L. Coleman. "Targeted therapy in gynecologic oncology: Biology, strategy, and assessment." Gynecologic Oncology 116, no. 2 (February 2010): 155–56. http://dx.doi.org/10.1016/j.ygyno.2009.12.009.

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18

Weberding, Nathaniel T., and Jennifer R. Marin. "Point-of-Care Ultrasound for Targeted Assessment of Shock." Pediatric Emergency Care 35, no. 8 (August 2019): 575–78. http://dx.doi.org/10.1097/pec.0000000000001891.

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19

Ruef, Christian. "Community-acquired pneumonia – risk assessment, empirical and targeted treatment." Therapeutische Umschau 58, no. 10 (October 1, 2001): 582–87. http://dx.doi.org/10.1024/0040-5930.58.10.582.

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Bei der Behandlung von Patienten mit ambulant erworbener Pneumonie steht der praktizierende Arzt vor zwei wichtigen Entscheidungen. Als Erstes muss er beurteilen, ob der an Pneumonie Erkrankte ambulant behandelt werden kann oder einem Spital zur stationären Therapie zugewiesen werden muss. Die zweite Entscheidung betrifft, falls eine ambulante Therapie gewählt wurde, die Verordnung des geeigneten Antibiotikums. Im Laufe der 90er Jahre wurde in den USA ein Prognose-Score entwickelt und validiert, der mit ausreichender Sicherheit diejenigen Patienten erkennt, die ein niedriges Komplikationsrisiko aufweisen und die somit in der Regel problemlos ambulant behandelt werden können. Andererseits sollten Patienten mit hohem Score (Risikoklassen III–V) primär stationär behandelt werden. Obwohl die Berechnung des Scores das Erheben einer stattlichen Zahl von Informationen erfordert, ist der Zusatzaufwand für den praktizierenden Arzt relativ gering, da die meisten Parameter bereits im Rahmen einer guten klinischen und paraklinischen Evaluation des Patienten erfasst werden. Die Details des Risikoscores nach Fine et al. werden in diesem Artikel erörtert. Zur empirischen antibiotischen Therapie von Patienten mit ambulant erworbener Pneumonie existieren verschiedene Richtlinien. Einige Kernaussagen der amerikanischen Richtlinien sind durch die lokale Resistenzsituation in den USA geprägt. Da sich die Situation bezüglich Antibiotikaresistenz in der Schweiz etwas anders präsentiert, wurden die amerikanischen Empfehlungen in diesem Artikel angepasst und auf das Wesentliche fokussiert. Die klinische Praxis zeigt, dass bei der überwiegenden Mehrzahl der Patienten mit ambulant erworbener Pneumonie die Therapie empirisch begonnen und auch empirisch fortgesetzt wird. Eine gezielte Therapie ist nur in den Ausnahmefällen möglich, in denen es gelingt, aus qualitativ gutem Sputum eine mikrobiologische Erregerdiagnose zu stellen.
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20

Yaziji, Hadi, and Clive R. Taylor. "PD-L1 Assessment for Targeted Therapy Testing in Cancer." Applied Immunohistochemistry & Molecular Morphology 25, no. 1 (January 2017): 1–3. http://dx.doi.org/10.1097/pai.0000000000000472.

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21

DONATELLO, JAMES M., and JOHN E. SAWYER. "ROAM — THE RESEARCH OPPORTUNITY ASSESSMENT MODEL FOR TARGETED INNOVATION." International Journal of Innovation and Technology Management 01, no. 01 (March 2004): 93–113. http://dx.doi.org/10.1142/s0219877004000064.

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Knowledge-driven companies are facing financial and competitive pressures that make them increasingly difficult to allocate the kinds of financial resources to research as they have in the past. For this reason, corporate scientists, research managers and business managers must understand both the financial and knowledge returns associated with the research they conduct so that they can best direct and allocate resources to research that provides both financial returns and establishes the knowledge basis for future discovery and innovation. We present a model for assessing research opportunities both from the standpoint of responding to market needs and pushing forward new knowledge development. We illustrate the use of this analytic model in both market pull and research push examples. We argue that both business and research managers in corporations can use this analytical discipline to better join the needs of business and the research divisions that support them.
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22

Davis, S. R., A. Tan, and R. J. Bell. "Targeted assessment of fracture risk in women at midlife." Osteoporosis International 26, no. 6 (January 29, 2015): 1705–12. http://dx.doi.org/10.1007/s00198-015-3046-9.

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23

Johar, Dina, and Larry Bernstein. "A targeted approach toward more accurate assessment of hypertension." Egyptian Journal of Chest Diseases and Tuberculosis 66, no. 3 (July 2017): 517–36. http://dx.doi.org/10.1016/j.ejcdt.2017.01.002.

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24

Money, Chris. "Improving the relevance and efficiency of human exposure assessments within the process of regulatory risk assessment." Environmental Science: Processes & Impacts 20, no. 1 (2018): 12–19. http://dx.doi.org/10.1039/c7em00434f.

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25

Ahmed, Yunus, Nitesh Nama, Ignas B. Houben, Joost A. van Herwaarden, Frans L. Moll, David M. Williams, C. Alberto Figueroa, Himanshu J. Patel, and Nicholas S. Burris. "Imaging surveillance after open aortic repair: a feasibility study of three-dimensional growth mapping." European Journal of Cardio-Thoracic Surgery 60, no. 3 (March 29, 2021): 651–59. http://dx.doi.org/10.1093/ejcts/ezab142.

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Abstract OBJECTIVES Confident growth assessment during imaging follow-up is often limited by substantial variability of diameter measurements and the fact that growth does not always occur at standard measurement locations. There is a need for imaging-based techniques to more accurately assess growth. In this study, we investigated the feasibility of a three-dimensional aortic growth assessment technique to quantify aortic growth in patients following open aortic repair. METHODS Three-dimensional aortic growth was measured using vascular deformation mapping (VDM), a technique which quantifies the localized rate of volumetric growth at the aortic wall, expressed in units of Jacobian (J) per year. We included 16 patients and analysed 6 aortic segments per patient (96 total segments). Growth was assessed by 3 metrics: clinically reported diameters, Jacobian determinant and targeted diameter re-measurements. RESULTS VDM was able to clearly depict the presence or absence of localized aortic growth and allows for an assessment of the distribution of growth and its relation to anatomic landmarks (e.g. anastomoses, branch arteries). Targeted diameter change showed a stronger and significant correlation with J (r = 0.20, P = 0.047) compared to clinical diameter change (r = 0.15, P = 0.141). Among 20/96 (21%) segments with growth identified by VDM, growth was confirmed by clinical measurements in 7 and targeted re-measurements in 11. Agreement of growth assessments between VDM and diameter measurements was slightly higher for targeted re-measurements (kappa = 0.38) compared to clinical measurements (kappa = 0.25). CONCLUSIONS Aortic growth is often uncertain and underappreciated when assessed via standard diameter measurements. Three-dimensional growth assessment with VDM offers a more comprehensive assessment of growth, allows for targeted diameter measurements and could be an additional tool to determine which post-surgical patients at high and low risk for future complications.
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Hou, Xiaohui, and Shiyan Chao. "Targeted or untargeted? The initial assessment of a targeted health insurance program for the poor in Georgia." Health Policy 102, no. 2-3 (October 2011): 278–85. http://dx.doi.org/10.1016/j.healthpol.2011.06.006.

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27

Gordiyenko, V., and O. Grygorash. "THE ASSESSMENT OF TARGETED PROGRAMS EFFECTIVENESS USING ECONOMIC – MATHEMATICAL METHODS." Bulletin of Taras Shevchenko National University of Kyiv Economics, no. 157 (2014): 27–31. http://dx.doi.org/10.17721/1728-2667.2014/157-4/5.

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28

Davies, D. Mark. "Self-assessment questions: Tuberous sclerosis: from gene to targeted therapy." Clinical Medicine 12, Suppl 6 (December 2012): s11. http://dx.doi.org/10.7861/clinmedicine.12-6-s11.

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Fiori, Jessica, Silvia Turroni, Marco Candela, and Roberto Gotti. "Assessment of gut microbiota fecal metabolites by chromatographic targeted approaches." Journal of Pharmaceutical and Biomedical Analysis 177 (January 2020): 112867. http://dx.doi.org/10.1016/j.jpba.2019.112867.

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30

Sallé, Guillaume, Jacques Cortet, Christine Koch, Fabrice Reigner, and Jacques Cabaret. "Economic assessment of FEC-based targeted selective drenching in horses." Veterinary Parasitology 214, no. 1-2 (November 2015): 159–66. http://dx.doi.org/10.1016/j.vetpar.2015.09.006.

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31

Kamimura, Kenya, Tsutomu Kanefuji, Takeshi Yokoo, Hiroyuki Abe, Takeshi Suda, Yuji Kobayashi, Guisheng Zhang, Yutaka Aoyagi, and Dexi Liu. "Safety Assessment of Liver-Targeted Hydrodynamic Gene Delivery in Dogs." PLoS ONE 9, no. 9 (September 24, 2014): e107203. http://dx.doi.org/10.1371/journal.pone.0107203.

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32

Boers-Doets, Christine Bettine, Hans Gelderblom, Joel Brian Epstein, Mario E. Lacouture, and Ad A. Kaptein. "Simultaneous assessment of targeted anticancer therapy-associated mucocutaneous adverse events." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): e20669-e20669. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e20669.

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e20669 Background: Mucocutaneous adverse events (mcAEs), including papulopustular rash, xerosis, pruritus, paronychia, hand-foot skin reaction, edema, taste alterations, oral pain and ulceration, hair-, periungual-, and ocular changes occur in the majority of patients during targeted anticancer therapies. Different mcAEs can be present with a variable symptom burden and affect upon patients’ quality of life. Use of standardized targeted therapy specific tools allows comparison of outcomes from different studies and in meta-analyses, advancing patient care and improving outcomes. A mcAE specific assessment tool about symptom burden is currently not available. A questionnaire which assesses both targeted therapy specific patient reported outcomes (PRO) measures and healthcare provider reported outcomes (HPRO) measures is warranted, therefore. Methods: A three-phase process was utilized for item generation, item reduction and scale construction. A comprehensive literature review was performed in PubMed, CINAHL and Embase, and study protocols were screened. Keywords were assessment, questionnaire, tool, EGFRI, and rash. All items with potential relevance for the tool were selected for further evaluation. Twentyone EGFRI treated patients filled out the draft-questionnaire. Results: The search resulted in a simultaneous tool in the form of 61 PRO, and 50 HPRO items. Both tools assess experienced mcAEs inclusive number of papules and pustules, area involved, severity and duration of the symptoms, used products, effectiveness of various (medical) interventions, treatment adherence and distress from the symptoms. Patient input resulted in the addition of 1 item, modification of 7 items, and deletion of 2 items. Conclusions: A novel tool has been generated to assess the experienced mcAEs and effectiveness of supportive care interventions. Since the patient and the provider report mcAEs simultaneously, the provided data are directly comparable, facilitating assessment of quality of life and, therefore, improving quality of medical care.
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Bjurlin, Marc A., and Samir S. Taneja. "Prediagnostic Risk Assessment with Prostate MRI and MRI-Targeted Biopsy." Urologic Clinics of North America 44, no. 4 (November 2017): 535–46. http://dx.doi.org/10.1016/j.ucl.2017.07.012.

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34

Mansilla, Veronica Boix, Elizabeth Dawes Duraisingh, Christopher R. Wolfe, and Carolyn Haynes. "Targeted Assessment Rubric: An Empirically Grounded Rubric for Interdisciplinary Writing." Journal of Higher Education 80, no. 3 (May 2009): 334–53. http://dx.doi.org/10.1080/00221546.2009.11779016.

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35

Desai, Hetal, Mohamed Y. Mahmoud, Jinlian Tan, Farnaz Minooei, Donald R. Demuth, and Jill M. Steinbach-Rankins. "Assessment of CafA Targeted BAR-Encapsulated Nanoparticles against Oral Biofilms." Pharmaceutics 12, no. 9 (September 1, 2020): 835. http://dx.doi.org/10.3390/pharmaceutics12090835.

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Porphyromonas gingivalis adherence to Streptococcus gordonii is a crucial initial event that facilitates the colonization of P. gingivalis, a key pathogen in periodontal disease. As such, blocking these early interactions may present a potential avenue to limit P. gingivalis colonization. Nanoparticles encapsulating a synthetic peptide BAR (BAR-encapsulated NPs) inhibit P. gingivalis/S. gordonii biofilm formation 1.8-fold more potently relative to free BAR. However, BAR-encapsulated NPs, like many orally delivered formulations, may benefit from a strategy that improves their retention in an open flow environment. Here, we sought to enhance the efficacy of BAR-encapsulated NPs by modifying their surfaces with coaggregation factor A (CafA), a fimbrial protein expressed by the early colonizer, Actinomyces oris. We demonstrate that the targeting moiety, CafA, enhances NP binding and exhibits specificity of adherence to S. gordonii, relative to other oral bacterial species. Furthermore, CafA-modified NPs release inhibitory concentrations of BAR for 12 h, a time frame relevant to oral dosage form delivery. Lastly, CafA-modified NPs potently inhibit P. gingivalis/S. gordonii biofilm formation for up to 12 h and are non-toxic at therapeutically-relevant concentrations. These results suggest that CafA-modified NPs represent a novel and efficacious delivery vehicle for localized, targeted delivery of BAR to P. gingivalis preferred niches.
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Sciallero, Claudia, Emanuele Daglio, and Andrea Trucco. "In vivoquantification of ultrasound targeted microbubbles to enhance cancer assessment." Contrast Media & Molecular Imaging 11, no. 4 (May 8, 2016): 313–18. http://dx.doi.org/10.1002/cmmi.1694.

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Veronica Boix Mansilla, Elizabeth Dawes Duraisingh, Christopher R. Wolfe, and Carolyn Haynes. "Targeted Assessment Rubric: An Empirically Grounded Rubric for Interdisciplinary Writing." Journal of Higher Education 80, no. 3 (2009): 334–53. http://dx.doi.org/10.1353/jhe.0.0044.

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Siegwald, Léa, Hélène Touzet, Yves Lemoine, David Hot, Christophe Audebert, and Ségolène Caboche. "Assessment of Common and Emerging Bioinformatics Pipelines for Targeted Metagenomics." PLOS ONE 12, no. 1 (January 4, 2017): e0169563. http://dx.doi.org/10.1371/journal.pone.0169563.

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Rugge, Massimo, Kentaro Sugano, Carmelo Scarpignato, Diana Sacchi, Walker Jove Oblitas, and Antonio Giuseppe Naccarato. "Gastric cancer prevention targeted on risk assessment: Gastritis OLGA staging." Helicobacter 24, no. 2 (February 17, 2019): e12571. http://dx.doi.org/10.1111/hel.12571.

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40

Stein, Eric D., and Brock Bernstein. "Integrating probabalistic and targeted compliance monitoring for comprehensive watershed assessment." Environmental Monitoring and Assessment 144, no. 1-3 (September 27, 2007): 117–29. http://dx.doi.org/10.1007/s10661-007-9950-5.

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41

Huamani, J., R. J. Passarella, H. M. Onishko, A. Fu, L. Geng, Z. Han, D. E. Hallahan, and R. Diaz. "Rapid Assessment of Malignant Glioma Susceptibility to Molecular Targeted Therapy." International Journal of Radiation Oncology*Biology*Physics 69, no. 3 (November 2007): S149. http://dx.doi.org/10.1016/j.ijrobp.2007.07.272.

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42

Parikh, Kinjal, Davecia Ragoonath Cameron, Tristin Abair, Patrick Kugel, and Arndt Vogel. "Targeted therapies in cholangiocarcinoma: Assessment of US oncologist practice patterns." Journal of Clinical Oncology 39, no. 3_suppl (January 20, 2021): 347. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.347.

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347 Background: Chemotherapy is a mainstay treatment modality for patients with advanced cholangiocarcinoma (CCA). Recent developments and new approvals have led to changing paradigms, incorporating the use of targeted therapies for patients with progressive disease. Given the need for a greater understanding of the molecular alterations, varying targets, and available and emerging therapies, education is needed to assess knowledge regarding these recent advances in unresectable CCA. The goal of this activity was to increase the knowledge of self-assess the learning needs of oncologists in treating patients with unresectable CCA. Methods: The education included 25 multiple choice questions in a continuing medical education (CME)-certified clinical practice assessment to assess practice gaps. The questions were designed to measure knowledge, competence, confidence, and attitudes of oncologists regarding clinical evidence, role of molecular testing, and place in the treatment paradigm for targeted therapies in unresectable CCA. The self-assessment was made available online to physicians as a learning tool to gain foundational knowledge, as well as receive feedback about their performance as compared to other test-takers, to improve self-awareness of their own personal educational gaps. The activity launched 6/24/20, and data are reported through 8/31/20. Results: A total of 1,009 learners, including 758 physicians, participated in the activity. Of the 104 oncologists that participated, a majority practiced in the community setting, saw patients with a range of cancers, and were not confident about using targeted therapies or recognizing targets for biomarker testing. Oncologists demonstrated the following gaps related to: NGS sequencing and biomarkers: 21% do not use; 32% use upon progressive disease; 35% did not realize that not all panels detect FGFR2 fusions; 20% do not test for biomarkers; 29% and 56% test for IDH or FGFR, respectively; 60% recognize the incidence of IDH1 mutations; Clinical trial (FIGHT202 and ClarIDHy): 45% were able to identify biomarker eligibility for pemigatinib; 9% were able to identify pemigatinib OS outcomes; 30% were able to recognize most common grade 3 AE of pemigatinib; 51% recognized the PFS endpoint with ivosidenib; 34% were able to identify eligibility for ivosidenib; 55% recognized most common AEs of ivosidenib. Conclusions: This CME-certified clinical practice assessment identified gaps in knowledge, competence, and confidence regarding testing and use of targeted therapies and emerging data in patients with unresectable CCA. As new data emerges and the number of targets and targeted therapies expand, continued education remains important to continue to optimize patient care.
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Buniag, Arianne Galino, Allen M. Pratt, and Jarom J. Ray. "Targeted Endodontic Microsurgery: A Retrospective Outcomes Assessment of 24 Cases." Journal of Endodontics 47, no. 5 (May 2021): 762–69. http://dx.doi.org/10.1016/j.joen.2021.01.007.

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44

Farmakis, Ioannis, David Bonneau, D. Jean Hutchinson, and Nicholas Vlachopoulos. "Targeted Rock Slope Assessment Using Voxels and Object-Oriented Classification." Remote Sensing 13, no. 7 (April 1, 2021): 1354. http://dx.doi.org/10.3390/rs13071354.

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Reality capture technologies, also known as close-range sensing, have been increasingly popular within the field of engineering geology and particularly rock slope management. Such technologies provide accurate and high-resolution n-dimensional spatial representations of our physical world, known as 3D point clouds, that are mainly used for visualization and monitoring purposes. To extract knowledge from point clouds and inform decision-making within rock slope management systems, semantic injection through automated processes is necessary. In this paper, we propose a model that utilizes a segmentation procedure which delivers segments ready to classify and be retained or rejected according to complementary knowledge-based filter criteria. First, we provide relevant voxel-based features based on the local dimensionality, orientation, and topology and partition them in an assembly of homogenous segments. Subsequently, we build a decision tree that utilizes geometrical, topological, and contextual information and enables the classification of a multi-hazard railway rock slope section in British Columbia, Canada into classes involved in landslide risk management. Finally, the approach is compared to machine learning integrating recent featuring strategies for rock slope classification with limited training data (which is usually the case). This alternative to machine learning semantic segmentation approaches reduces substantially the model size and complexity and provides an adaptable framework for tailored decision-making systems leveraging rock slope semantics.
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Snyder, Rachel, Katelyn White, Janet Glowicz, Shannon Novosad, Elizabeth Soda, David Kuhar, and Ronda Sinkowitz-Cochran. "Targeted Assessment for Prevention Facility Assessments: The Most Common CAUTI and CLABSI Infection Prevention Gaps." Infection Control & Hospital Epidemiology 41, S1 (October 2020): s4—s5. http://dx.doi.org/10.1017/ice.2020.475.

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Background: The Targeted Assessment for Prevention (TAP) strategy is a quality improvement framework created by the Centers for Disease Control and Prevention (CDC) to facilitate the reduction of healthcare-associated infections (HAIs). TAP facility assessments are a component of the TAP strategy and are completed by staff across the facility to help identify perceptions of and target infection prevention gaps. We have described the gaps most commonly reported by facilities completing TAP facility assessments for catheter-associated urinary tract infections (CAUTIs) and central-line–associated bloodstream infections (CLABSIs). Methods: TAP CAUTI and CLABSI assessments were completed by acute-care facilities across the nation, with CDC technical assistance, from December 2014 to August 2019. Similar questions across 2 versions of CAUTI assessments and 3 versions of CLABSI assessments were combined. Analysis was limited to facilities with ≥10 assessments. Infection prevention gaps were defined as ≥33% respondents answering Unknown, ≥33% respondents answering “no,” or ≥50% of respondents answering “no” and “unknown” or “never” and “rarely” “sometimes” “unknown.” The analysis was completed at the facility level, and the gaps most commonly reported across facilities were identified. Results: In total, 1,942 CAUTI assessments from 42 facilities in 12 states and 1,623 CLABSI assessments from 29 facilities in 11 states were included for analysis. The mean numbers of assessments per facility were 46.2 for CAUTIs and 56.0 for CLABSIs. Across both CAUTIs and CLABSIs, commonly reported perceptions about infection prevention gaps included lack of physician and nurse champions for prevention activities, failure to conduct competency assessments, and inconsistency in select device insertion practices (Fig. 1). For CAUTIs, lack of practices to facilitate timely removal of urinary catheters were also commonly reported, with one-third of facilities reporting inconsistency in use of alerts for catheter removal, 78.6% reporting lack of physician response to these alerts, and 90.5% reporting deficiencies in removing unnecessary catheters in the postanesthesia care unit. For CLABSIs, 79.3% of facilities reported failure to replace central lines within 48 hours after emergent insertion, and 62.1% reported that feedback was not provided to staff on central-line device utilization ratios. Conclusion: For both assessments, absence of CAUTI and CLABSI prevention champions, failure to conduct competency assessments, and inconsistency in performing device insertion practices were commonly reported across facilities. These common gaps have and will continue to inform the development of tools and resources to improve infection prevention practices as well as help to better target the implementation of interventions.Funding: NoneDisclosures: None
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Wiehe, Sarah, David Craig, Matthew Wilcox, Emily Hardwick, Carrie Lawrence, Fiona Schicho, and Brenda Hudson. "4409 Indiana Clinical & Translational Science Monon Collaborative – Community Impact Hubs." Journal of Clinical and Translational Science 4, s1 (June 2020): 86–87. http://dx.doi.org/10.1017/cts.2020.273.

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OBJECTIVES/GOALS: Conduct an environmental scan of Marion County (Indianapolis) neighborhoods using electronic medical record data, state health data, and social and economic dataDevelop strong network of community collaboratorsConduct a thorough assessment for each targeted neighborhood by listening and understanding the pressing health issues in the community and working together to design and deliver solutionsMETHODS/STUDY POPULATION: Identify measures in the 3 domains of vulnerability, health and assets for the targeted neighborhoods and conduct bivariate descriptive statistics and multivariable regression analyses to investigate association between measures of vulnerability and health outcomes.Initiate relationships with leaders and residents in targeted neighborhoodsLocate organizations working in targeted neighborhoods through online mapping software and word-of-mouth at neighborhood events, and created a spreadsheet with contact information.Conduct multidisciplinary assessment (i.e. key informant interviews, focus groups, town hall meetings) of the targeted neighborhood.Iteratively synthesize assessments to develop areas of interest and relevance to the community.Develop a road map for solutions identified by the community.RESULTS/ANTICIPATED RESULTS: The results from the environmental scan conducted will be displayed in a report and visual “map” of health outcomes and health determinants, including assets and barriers for the targeted neighborhoods. The research team will use results from the environmental scan coupled with listening activities including attendance at community events, key informant interviews and focus groups to develop relationships and strong collaborations with the targeted neighborhood stakeholders. The relationship building between the research team and community will provide increased trust and engagement that will further enhance the effectiveness of the assessments completed with the targeted neighborhood. The assessments will help to empower communities to develop sustainable solutions and drive future work that will lead to future grant applications and larger-scale implementation in other community impact hub neighborhoods. DISCUSSION/SIGNIFICANCE OF IMPACT: Through the community impact hub work, we will develop collaborative efforts with targeted neighborhoods with the greatest health inequities in the Marion County area. In partnership with these neighborhoods, we will build a foundation – a network of community collaborators and a focused plan – upon which we will improve the health outcomes of residents while learning best practices on how to do so.
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Reddy, Marisa, Randy Borum, John Berglund, Bryan Vossekuil, Robert Fein, and William Modzeleski. "Evaluating risk for targeted violence in schools: Comparing risk assessment, threat assessment, and other approaches." Psychology in the Schools 38, no. 2 (2001): 157–72. http://dx.doi.org/10.1002/pits.1007.

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48

Stanger, Dylan, Vesna Mihajlovic, Joel Singer, Sameer Desai, Rami El-Sayegh, and Graham C. Wong. "Editor’s Choice-Effects of targeted temperature management on mortality and neurological outcome: A systematic review and meta-analysis." European Heart Journal: Acute Cardiovascular Care 7, no. 5 (November 27, 2017): 467–77. http://dx.doi.org/10.1177/2048872617744353.

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Aims: The purpose of this study was to conduct a systematic review, and where applicable meta-analyses, examining the evidence underpinning the use of targeted temperature management following resuscitation from cardiac arrest. Methods and results: Multiple databases were searched for publications between January 2000–February 2016. Nine Population, Intervention, Comparison, Outcome questions were developed and meta-analyses were performed when appropriate. Reviewers extracted study data and performed quality assessments using Grading of Recommendations, Assessment, Development and Evaluation methodology, the Cochrane Risk Bias Tool, and the National Institute of Health Study Quality Assessment Tool. The primary outcomes for each Population, Intervention, Comparison, Outcome question were mortality and poor neurological outcome. Overall, low quality evidence demonstrated that targeted temperature management at 32–36°C, compared to no targeted temperature management, decreased mortality (risk ratio 0.76, 95% confidence interval 0.61–0.92) and poor neurological outcome (risk ratio 0.73, 95% confidence interval 0.60–0.88) amongst adult survivors of out-of-hospital cardiac arrest with an initial shockable rhythm. Targeted temperature management use did not benefit survivors of in-hospital cardiac arrest nor out-of-hospital cardiac arrest survivors with a non-shockable rhythm. Moderate quality evidence demonstrated no benefit of pre-hospital targeted temperature management initiation. Low quality evidence showed no difference between endovascular versus surface cooling targeted temperature management systems, nor any benefit of adding feedback control to targeted temperature management systems. Low quality evidence suggested that targeted temperature management be maintained for 18–24 h. Conclusions: Low quality evidence supports the in-hospital initiation and maintenance of targeted temperature management at 32–36°C amongst adult survivors of out-of-hospital cardiac arrest with an initial shockable rhythm for 18–24 h. The effects of targeted temperature management on other populations, the optimal rate and method of cooling and rewarming, and effects of fever require further study.
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Kasten, Benjamin B., Soldano Ferrone, Kurt R. Zinn, and Donald J. Buchsbaum. "B7-H3-targeted Radioimmunotherapy of Human Cancer." Current Medicinal Chemistry 27, no. 24 (July 7, 2020): 4016–38. http://dx.doi.org/10.2174/0929867326666190228120908.

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Background: Targeted Radioimmunotherapy (RIT) is an attractive approach to selectively localize therapeutic radionuclides to malignant cells within primary and metastatic tumors while sparing normal tissues from the effects of radiation. Many human malignancies express B7-H3 on the tumor cell surface, while expression on the majority of normal tissues is limited, presenting B7-H3 as a candidate target for RIT. This review provides an overview of the general principles of targeted RIT and discusses publications that have used radiolabeled B7-H3-targeted antibodies for RIT of cancer in preclinical or clinical studies. Methods: Databases including PubMed, Scopus, and Google Scholar were searched for publications through June 2018 using a combination of terms including “B7-H3”, “radioimmunotherapy”, “targeted”, “radiotherapy”, and “cancer”. After screening search results for relevancy, ten publications were included for discussion. Results: B7-H3-targeted RIT studies to date range from antibody development and assessment of novel Radioimmunoconjugates (RICs) in animal models of human cancer to phase II/III trials in humans. The majority of clinical studies have used B7-H3-targeted RICs for intra- compartment RIT of central nervous system malignancies. The results of these studies have indicated high tolerability and favorable efficacy outcomes, supporting further assessment of B7-H3-targeted RIT in larger trials. Preclinical B7-H3-targeted RIT studies have also shown encouraging therapeutic outcomes in a variety of solid malignancies. Conclusion: B7-H3-targeted RIT studies over the last 15 years have demonstrated feasibility for clinical development and support future assessment in a broader array of human malignancies. Future directions worthy of exploration include strategies that combine B7-H3- targeted RIT with chemotherapy or immunotherapy.
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Momsen, Jennifer L., Tammy M. Long, Sara A. Wyse, and Diane Ebert-May. "Just the Facts? Introductory Undergraduate Biology Courses Focus on Low-Level Cognitive Skills." CBE—Life Sciences Education 9, no. 4 (December 2010): 435–40. http://dx.doi.org/10.1187/cbe.10-01-0001.

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Introductory biology courses are widely criticized for overemphasizing details and rote memorization of facts. Data to support such claims, however, are surprisingly scarce. We sought to determine whether this claim was evidence-based. To do so we quantified the cognitive level of learning targeted by faculty in introductory-level biology courses. We used Bloom's Taxonomy of Educational Objectives to assign cognitive learning levels to course goals as articulated on syllabi and individual items on high-stakes assessments (i.e., exams and quizzes). Our investigation revealed the following: 1) assessment items overwhelmingly targeted lower cognitive levels, 2) the cognitive level of articulated course goals was not predictive of the cognitive level of assessment items, and 3) there was no influence of course size or institution type on the cognitive levels of assessments. These results support the claim that introductory biology courses emphasize facts more than higher-order thinking.
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