Academic literature on the topic 'Targeted antigen delivery'
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Journal articles on the topic "Targeted antigen delivery"
Wengerter, Brian C., Joseph A. Katakowski, Jacob M. Rosenberg, Chae Gyu Park, Steven C. Almo, Deborah Palliser, and Matthew Levy. "Aptamer-targeted Antigen Delivery." Molecular Therapy 22, no. 7 (July 2014): 1375–87. http://dx.doi.org/10.1038/mt.2014.51.
Full textBourque, Jessica, and Daniel Hawiger. "Applications of Antibody-Based Antigen Delivery Targeted to Dendritic Cells In Vivo." Antibodies 11, no. 1 (January 25, 2022): 8. http://dx.doi.org/10.3390/antib11010008.
Full textKawasaki, Norihito, Weihsu Chen, Jose Vela, Corwin Nycholat, Igor Maricic, Kumar Vipin, Paul Crocker, Mitchell Kronenberg, and James Paulson. "Efficient lipid antigen presentation to NKT cells by targeting CD169/Siglec-1 on macrophages with its glycan ligand. (100.49)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 100.49. http://dx.doi.org/10.4049/jimmunol.186.supp.100.49.
Full textWi, Tae In, Yeongseon Byeon, Ji Eun Won, Jae Myeong Lee, Tae Heung Kang, Jeong-Won Lee, Young Joo Lee, Anil K. Sood, Hee Dong Han, and Yeong-Min Park. "Selective Tumor-Specific Antigen Delivery to Dendritic Cells Using Mannose-Labeled Poly(d, l-lactide-co-glycolide) Nanoparticles for Cancer Immunotherapy." Journal of Biomedical Nanotechnology 16, no. 2 (February 1, 2020): 201–11. http://dx.doi.org/10.1166/jbn.2020.2883.
Full textSwanson, Anna, Danli Wu, Isere Kuiatse, Hong-Sung Kim, Helen Heslop, Malcolm Brenner, and Patricia Yotnda. "Delivery of tumor-targeted immunotoxin by tumor-specific T cells (155.19)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 155.19. http://dx.doi.org/10.4049/jimmunol.186.supp.155.19.
Full textYuba, Eiji, Yoshiki Fukaya, Shin Yanagihara, Nozomi Kasho, and Atsushi Harada. "Development of Mannose-Modified Carboxylated Curdlan-Coated Liposomes for Antigen Presenting Cell Targeted Antigen Delivery." Pharmaceutics 12, no. 8 (August 11, 2020): 754. http://dx.doi.org/10.3390/pharmaceutics12080754.
Full textMurty, Rohan, Abishek Sankaranarayanan, Isabella I. Bowland, Juan Mena-Lapaix, and Mark R. Prausnitz. "Angled Insertion of Microneedles for Targeted Antigen Delivery to the Epidermis." Pharmaceutics 14, no. 2 (February 1, 2022): 347. http://dx.doi.org/10.3390/pharmaceutics14020347.
Full textShaw, Christine A., and Michael N. Starnbach. "Stimulation of CD8+ T Cells following Diphtheria Toxin-Mediated Antigen Delivery into Dendritic Cells." Infection and Immunity 74, no. 2 (February 2006): 1001–8. http://dx.doi.org/10.1128/iai.74.2.1001-1008.2006.
Full textCiccotelli, Jo Erika, Helene Toussaint, Geza Erdos, Cara Carey, Simon Watkins, and Louis Falo. "Intradermal immunization with polyguanine conjugated antigens enables targeted and sustained delivery of protein antigens to dendritic cells in vivo. (APP3P.111)." Journal of Immunology 192, no. 1_Supplement (May 1, 2014): 111.12. http://dx.doi.org/10.4049/jimmunol.192.supp.111.12.
Full textRaiber, Eun-Ang, Calogero Tulone, Yanjing Zhang, Luisa Martinez-Pomares, Emily Steed, Anna M. Sponaas, Jean Langhorne, Mahdad Noursadeghi, Benjamin M. Chain, and Alethea B. Tabor. "Targeted Delivery of Antigen Processing Inhibitors to Antigen Presenting Cells via Mannose Receptors." ACS Chemical Biology 5, no. 5 (April 27, 2010): 461–76. http://dx.doi.org/10.1021/cb100008p.
Full textDissertations / Theses on the topic "Targeted antigen delivery"
Rohrbach, Florian. "Induction of anti-tumor immunity by targeted delivery of ErbB2 cancer vaccines to antigen-presenting cells." Université Louis Pasteur (Strasbourg) (1971-2008), 2004. http://www.theses.fr/2004STR13026.
Full textStylianou, Elena. "Specific cell-targeted delivery of mycobacterial antigens in vivo." Thesis, St George's, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546779.
Full textSchumacher, Dominik. "Site-specific functionalization of antigen binding proteins for cellular delivery, imaging and target modulation." Doctoral thesis, Humboldt-Universität zu Berlin, 2017. http://dx.doi.org/10.18452/18547.
Full textAntibodies and antigen binding proteins conjugated to fluorophores, tracers and drugs are powerful molecules that enabled the development of valuable diagnostic and therapeutic tools. However, the conjugation itself is highly challenging and despite intense research efforts remains a severe bottleneck. In addition to that, antibodies and antigen binding proteins are often not functional within cellular environments and unable to penetrate the cellular membrane. Therefore, their use is limited to extracellular targets leaving out a vast number of important antigens. Both limitations are core aspects of the presented thesis. With Tub-tag labeling, a novel and versatile method for the site-specific functionalization of biomolecules and antigen binding proteins was developed expanding the toolbox of protein functionalization. The method is based on the microtubule enzyme tubulin tyrosine ligase. Tub-tag labeling was successfully applied for the site-specific functionalization of different proteins including antigen binding nanobodies which enabled confocal microscopy, protein enrichment and super-resolution microscopy. In addition to that, cell permeable antigen binding nanobodies have been generated constituting a long thought goal of tracking and manipulating intracellular targets by in vitro functionalized antigen binding proteins. To achieve this goal, two different nanobodies were functionalized at their C-terminus with linear and cyclic cell-penetrating peptides using expressed protein ligation. These peptides triggered the endocytosis independent uptake of the nanobodies with immediate bioavailability. Taken together, Tub-tag labeling and the generation of cell-permeable antigen binding nanobodies strongly add to the functionalization of antibodies and their use in biochemistry, cell biology and beyond.
Polak, Roberta. "Desenvolvimento e fabricação de filmes ultra-finos, obtidos pela técnica layer-by-layer, para aplicações na entrega direcionada de fármacos e na captura seletiva de bio-marcadores." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/9/9135/tde-27042015-152718/.
Full textThe overall goal of this thesis was to exploit the versatility of polyelectrolite multilayers (PEM) to be applied in drug delivery systems and biofunctionalizable films for biomedical applications. PEM films assembled by the layer-by-layer technique were explored in three main applications. In the first part of this work, the development of a functionalization protocol of poly(allylamine)/poly(styrene sulfonate), PAH/SPS was explored. The optimal film parameters to the use of biotinylated multilayers were applied for the capture and detection of prostate specific antigen (PSA) protein in the range of 100 to 0.1 ng/mL, by using quantum dots. Compared to previous work, this system presented a good sensitivity for PSA detection that is within the clinical limit range of 0.4 to 0.1 ng/mL. The second application involved the creation of a novel sacrificial multilayer film. Films based in natural interactions of bovine submaxillary mucin and the lectin jacalin, BSM/JAC were assembled. BSM/JAC films showed stability when underwent a wide rage of pH (pH 3 to 9) and high ionic strength (5 M NaCl) solutions. BSM/JAC dissolution could be triggered released by incubation in melibiose at 37 °C in pH 7.4 buffer, without cytotoxicity. In the last part of this work the incorporation of echogenic liposomes (ELIP) into cell backpacks was investigated. Cell backpacks are 7-10 µm diameter patches that can be fabricated through LbL polymer deposition onto a photopatterned array to create a stacked composite of three stratified multilayer systems: a releasable region for easy detachment from the substrate, a drug payload region, and a cell adhesive region. The use of ELIP allowed up to 9x more doxorubicin (DOX) loading when compared to free drug in solution adsorbed through the films. DOX release from films was monitored for over 25 days. ELIP-DOX backpacks were then attached to mouse monocytes and their viability monitored by 72h. Empty backpacks showed to decrease monocytes proliferation over the course of 72h, while ELIP-DOX backpacks showed a dramatic decrease in cell population, showing that DOX effects were enhancement in drug potency by its proximity.
Chu, Hin Lun. "Intracellular delivery of radioimmunoconjugates that target the cancer testis antigen, NY-ESO-1." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:84c830c4-c216-4b2c-8383-e1119d77c295.
Full textSchumacher, Dominik [Verfasser], Christian P. R. [Gutachter] Hackenberger, Dorothea [Gutachter] Fiedler, and Heinreich [Gutachter] Leonhardt. "Site-specific functionalization of antigen binding proteins for cellular delivery, imaging and target modulation / Dominik Schumacher ; Gutachter: Christian P. R. Hackenberger, Dorothea Fiedler, Heinreich Leonhardt." Berlin : Humboldt-Universität zu Berlin, 2017. http://d-nb.info/1185578390/34.
Full textPereira, Inês Sousa. "Carcinoembryonic antigen targeted polymeric nanoparticles for drug delivery." Master's thesis, 2017. https://hdl.handle.net/10216/108253.
Full textPereira, Inês Sousa. "Carcinoembryonic antigen targeted polymeric nanoparticles for drug delivery." Dissertação, 2017. https://hdl.handle.net/10216/108253.
Full textWhipple, Emily Christine. "Targeted delivery of antigens to follicular dendritic cells via a monoclonal antibody specific for complement receptor 2 on marginal zone B cells : dynamics of delivery and applications towards vaccine development /." 2006. http://wwwlib.umi.com/dissertations/fullcit/3235122.
Full textBlažková, Kristýna. "Chemicky modifikované částice z myšího polyomaviru a jejich interakce s membránově vázaným nádorovým antigenem specifickým pro prostatu (PSMA)." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-337154.
Full textBooks on the topic "Targeted antigen delivery"
Manoury, Bénédicte, and Piergiuseppe De Berardinis, eds. Targeted Antigen Delivery: Bridging Innate and Adaptive Immunity. Frontiers Media SA, 2019. http://dx.doi.org/10.3389/978-2-88945-833-2.
Full textGordon, Siamon. Macrophage As Therapeutic Target. Springer London, Limited, 2012.
Find full textGordon, Siamon. The Macrophage as Therapeutic Target. Springer, 2012.
Find full textThe Macrophage as Therapeutic Target. Springer, 2003.
Find full textBook chapters on the topic "Targeted antigen delivery"
Dobrica, Mihaela-Olivia, Catalin Lazar, and Norica Branza-Nichita. "Production of Chimeric Hepatitis B Virus Surface Antigens in Mammalian Cells." In Vaccine Delivery Technology, 83–94. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0795-4_7.
Full textPalacio-Castañeda, Valentina, Roland Brock, and Wouter P. R. Verdurmen. "Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen." In Methods in Molecular Biology, 129–41. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2010-6_8.
Full textKandil, Rima, Daniel Feldmann, Yuran Xie, and Olivia M. Merkel. "Evaluating the Regulation of Cytokine Levels After siRNA Treatment in Antigen-Specific Target Cell Populations via Intracellular Staining." In Nanotechnology for Nucleic Acid Delivery, 323–31. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9092-4_21.
Full textPradeep, Andrew, R. Sethu Nagarajan, and H. Fazil. "Immune-Targeted Nanomedicine." In Handbook of Research on Nano-Strategies for Combatting Antimicrobial Resistance and Cancer, 294–305. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-5049-6.ch014.
Full textBhattacharya, Sankha, and Kapil Gore. "Targeted Cancer Therapy Using Nanoparticles and Antibody Fragments." In Advances in Precision Medicine Oncology. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96550.
Full textSingh, M. "Use of Nanomaterials-based Enzymes in Vaccine Production and Immunization." In Nanomaterial-Supported Enzymes, 240–60. Materials Research Forum LLC, 2022. http://dx.doi.org/10.21741/9781644901977-9.
Full textPeine, Kevin J., Naihan Chen, Eric M. Bachelder, and Kristy M. Ainslie. "Drug Delivery Strategies for Tolerogenic Therapy for Autoimmune Diseases in an Antigen-Specific Manner." In Chronic Illness and Long-Term Care, 112–40. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-7122-3.ch007.
Full textBicak, Bilge, Serda Kecel Gunduz, and Aysen E. Ozel. "Advancements in Cancer Therapeutics." In Handbook of Research on Advancements in Cancer Therapeutics, 382–412. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-6530-8.ch013.
Full textRajeswari, P. Raja, S. Viswanadha Raju, Amira S. Ashour, and Nilanjan Dey. "Insilico Approach for Epitope Prediction toward Novel Vaccine Delivery System Design." In Advances in Multimedia and Interactive Technologies, 256–66. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-1025-3.ch012.
Full textRachmawati, Hidajah, Raditya Weka Nugraheni, and Firasti A.N. Sumadi. "In-Silico Approach in the Development of Salmonella Epitope Vaccine." In Salmonella - a Challenge From Farm to Fork [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96313.
Full textConference papers on the topic "Targeted antigen delivery"
Zhang, Lei, Feiyu Lu, Ibrahim Asadullah Tahmid, Shakiba Davari, Lee Lisle, Nicolas Gutkowski, Luke Schlueter, and Doug A. Bowman. "Fantastic Voyage 2021: Using Interactive VR Storytelling to Explain Targeted COVID-19 Vaccine Delivery to Antigen-presenting Cells." In 2021 IEEE Conference on Virtual Reality and 3D User Interfaces Abstracts and Workshops (VRW). IEEE, 2021. http://dx.doi.org/10.1109/vrw52623.2021.00230.
Full textBanerjee, Rupak K., Meinrad Praxmaraer, Ilhan Dilber, Peter Bungay, William van Osdol, and Cynthia Sung. "Numerical Simulation of Antibody Penetration in a Solid Tumor Nodule Using Finite Element Method." In ASME 1998 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1998. http://dx.doi.org/10.1115/imece1998-0058.
Full textCremel, Magali, Nathalie Guerin, Quitterie Barthe, Vanessa Bourgeaux, Willy Berlier, Françoise Horand, and Yann Godfrin. "Abstract 2356: Erythrocytes used as tumor antigen delivery system to target antigen-presenting cells embody an innovative approach forin situcancer immunotherapy." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-2356.
Full textCheung, Lawrence H., Khalid A. Mohamedali, Walter N. Hittelman, and Michael G. Rosenblum. "Abstract 2780: Engineering human fusion constructs for targeted delivery of granzyme B to CD33 and CEA antigens." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-2780.
Full textAsundi, Jyoti, Lisa Crocker, Jarrod Tremayne, Paul Polakis, and Ron Firestein. "Abstract 947: An antibody drug conjugate (ADC) directed to lymphocyte antigen 6 complex, locus E (LY6E) delivers targeted chemotherapy to a wide range of solid tumor malignancies." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-947.
Full textReports on the topic "Targeted antigen delivery"
Palmer, Guy, Varda Shkap, Wendy Brown, and Thea Molad. Control of bovine anaplasmosis: cytokine enhancement of vaccine efficacy. United States Department of Agriculture, March 2007. http://dx.doi.org/10.32747/2007.7695879.bard.
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