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Dissertations / Theses on the topic 'Target domain'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Gustafsson, Fredrik, and Erik Linder-Norén. "Automotive 3D Object Detection Without Target Domain Annotations." Thesis, Linköpings universitet, Datorseende, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148585.

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In this thesis we study a perception problem in the context of autonomous driving. Specifically, we study the computer vision problem of 3D object detection, in which objects should be detected from various sensor data and their position in the 3D world should be estimated. We also study the application of Generative Adversarial Networks in domain adaptation techniques, aiming to improve the 3D object detection model's ability to transfer between different domains. The state-of-the-art Frustum-PointNet architecture for LiDAR-based 3D object detection was implemented and found to closely match

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2

Collins, K. M. "Target recognition by multi-domain RNA-binding proteins." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1460867/.

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Multi-functional RNA binding proteins regulate and coordinate the many steps of RNA metabolism. Accurate functioning of these processes is vital in cells and misregulation has been linked to many human diseases. RNA binding proteins contain multiple RNA binding domains. The ability to perform multiple functions depends on the recognition of a diverse range of targets and domains are used combinatorially to achieve this. In this thesis I ask how the sequence specificity of low affinity RNA-binding domains and the interplay between said domains plays a role in RNA target selectivity. Within this

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3

Davis, Alicia Morgan. "CHARACTERIZATION OF INFLUENZA NUCLEOPROTEIN BODY DOMAIN AS ANTIVIRAL TARGET." CSUSB ScholarWorks, 2016. https://scholarworks.lib.csusb.edu/etd/364.

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Influenza is a segmented negative strand RNA virus. Each RNA segment is encapsulated by viral nucleoprotein (NP) and bound by the viral RNA dependent RNA polymerase (RdRP) to form viral ribonucleoproteins (vRNPs) responsible for RNA synthesis. NP is a structural component of the vRNP but also interacts with both viral and host factors to regulate viral RNA expression. NP is conserved among influenza A isolates, making NP interactions compelling antiviral targets. Here I characterize mutations within 5 amino acids of NP that comprise an accessible region of the NP body domain, as determined by

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4

Atkins, Jane. "Biochemical characterisation of the catalytic domain of neuropathy target esterase." Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29643.

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Neuropathy target esterase (NTE) is an integral membrane protein found predominantly in neurones. Covalent modification of NTE's active site serine, by certain organophosphates (OPs), results in a neurodegenerative syndrome. NTE's physiological substrate is unknown and its catalytic activity does not seem to be vital in the adult animal. The enzyme domain of human NTE (residues 727-1216), called NEST, was expressed in E. coli and reacted with a carboxyl ester substrate and OP inhibitors the same as native NTE. During purification catalytic activity was lost, but was restored by reconstitution

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5

Bishoff, Josef P. "Target detection using oblique hyperspectral imagery : a domain trade study /." Online version of thesis, 2008. http://hdl.handle.net/1850/7834.

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Kucheruk, Liliya. "Modern English Legal Terminology : linguistic and cognitive aspects." Thesis, Bordeaux 3, 2013. http://www.theses.fr/2013BOR30016/document.

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La présente étude intitulée «Terminologie juridique moderne de la langue anglaise: aspects linguistiques et cognitifs » aborde le langage juridique contemporain dans le cadre de la linguistique cognitive. Les objectifs de l'étude sont d'étudier les particularités de la terminologie juridique et de proposer des principes de systématisation, en se référant à la théorie cognitive de la métaphore. Il s’agit principalement : 1) de déterminer les concepts de base utilisés métaphoriquement dans la langue juridique ; 2) d'établir les correspondances principales entre domaines et les corrélations entre

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Niemiec, Moritz Sebastian. "Human copper ion transfer : from metal chaperone to target transporter domain." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100511.

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Many processes in living systems occur through transient interactions among proteins. Those interactions are often weak and are driven by small changes in free energy. Due to the short-living nature of these interactions, our knowledge about driving forces, dynamics and structures of these types of protein-protein heterocomplexes are though limited. This is especially important for cellular copper (Cu) trafficking: Copper ions are essential for all eukaryotes and most bacteria. As a cofactor in many enzymes, copper is especially vital in respiration or detoxification. Since the same features t

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8

Schaus, Brian M. "Improving maritime domain awareness using neural networks for target of interest classification." Thesis, Monterey, California: Naval Postgraduate School, 2015. http://hdl.handle.net/10945/45252.

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Approved for public release; distribution is unlimited<br>Techniques for classifying maritime domain targets-of-interest within images are explored in this thesis. Geometric and photometric features within each image are extracted from processed images and are used to train a neural network. The trained neural network is tested with features of a known object. In the binary classification case, the neural network is used to determine whether a ship is present or not present in the image. In the multi-class and multi-level classification cases, the neural network is used to determine if the obj

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Ferrari, Giovanna Maria. "The interaction of the Î±2 chimaerin SH2 domain with target proteins." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325678.

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10

Chen, Yen-Lun. "Margin and Domain Classifications for Target Detection over Huge Population of Outliers." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1269539889.

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11

Rydh, Sandra. "Mr Metaphor Man : A study of Bob Dylan's lyrics." Thesis, Linnéuniversitetet, Institutionen för språk och litteratur, SOL, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-16879.

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This study was carried out in order to investigate the purpose of Bob Dylan’s creative metaphors. Focus was on whether they were used for artistic effect or to simplify and concretize abstract concepts. Ten songs written in the last five decades were randomly selected and searched for occurrences of creative metaphors. The metaphors found were chronologically listed and discussed in terms of potential source and target domains in order to determine their purpose. The results showed rather clearly that Dylan’s creative metaphors, regardless of whether the domains were abstract or concrete, seem

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Behrle, Charles D. "Computer simulation studies of multiple broadband target localization via frequency domain beamforming for planar arrays." Thesis, Monterey, California. Naval Postgraduate School, 1988. http://hdl.handle.net/10945/22976.

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Approved for public release; distribution is unlimited<br>Computer simulation studies of a frequency domain adaptive beamforming algorithm are presented. These simulation studies were conducted to determine the multiple broadband target localization capability and the full angular coverage capability of the algorithm. The algorithm was evaluated at several signal-to-noise ratios with varying sampling rates. The number of iterations that the adaptive algorithm took to reach a minimum estimation error was determined. Results of the simulation studies indicate that the algorithm can localize mult

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Boichenko, Iuliia [Verfasser], and Andrei [Akademischer Betreuer] Lupas. "The CULT domain of cereblon : a pharmacological target and teratogenicity gateway / Iuliia Boichenko ; Betreuer: Andrei Lupas." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1168728347/34.

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Parrish, Denwood. "TARGET ELEMENT SIZES FOR FINITE ELEMENT TIDAL MODELS FROM A DOMAIN-WIDE, LOCALIZED TRUNCATION ERROR ANALYSIS INCORPORATING BOTTO." Doctoral diss., University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3587.

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A new methodology for the determination of target element sizes for the construction of finite element meshes applicable to the simulation of tidal flow in coastal and oceanic domains is developed and tested. The methodology is consistent with the discrete physics of tidal flow, and includes the effects of bottom stress. The method enables the estimation of the localized truncation error of the nonconservative momentum equations throughout a triangulated data set of water surface elevation and flow velocity. The method's domain-wide applicability is due in part to the formulation of a new loca

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Manning, Lauren Brooke. "Experimental Evaluation of Discoid Domain Receptor 2 as an Ideal Target for Development of Disease-Modifying Osteoarthritis Drugs." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17331959.

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Abstract: Osteoarthritis (OA) affects 250 million people worldwide. Currently, no targets for disease-modifying osteoarthritis drugs exist. Matrix metalloproteinase-13 (MMP-13) would make it an ideal target; however, its broad biological effects restrict its application as a target enzyme of inhibitory drugs in the treatment of OA. The expression and activation of discoidin domain receptor 2 (DDR2) is increased in human OA tissues and mouse models of OA and was co-localized with elevated expression of MMP-13 in degenerative articular cartilages. In healthy articular cartilage, DDR2 is kept

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Monaghan, Amy Elizabeth. "The amino terminal domain of steroid hormone receptors as a novel drug target : identification of small molecule inhibitors." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230709.

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Steroid hormone receptors (SHRs) are well validated therapeutic targets in a number of diseases. Current therapies competitively antagonise the ligand binding domain (LBD), blocking activation of the receptor and downstream signalling pathways. However cross-reactivity can be seen amongst the antagonists of different SHRs eliciting unwanted side effects. Additionally the acquisition of resistance to current therapies in diseases such as prostate cancer limits their use. The amino-terminal domain (NTD) of SHRs provides an alternative target for antagonism by allowing potential therapies to bloc

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Гнаповська, Людмила Вадимівна, Людмила Вадимовна Гнаповская, Liudmyla Vadymivna Hnapovska та М. В. Дука. "Концепт "Культура" в номінативному просторі "Кохання"". Thesis, Редакційно-видавничий відділ Житомирського державного університету ім. Івана Франка, 2005. http://essuir.sumdu.edu.ua/handle/123456789/62458.

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Ономасіологічний простір концепту "Кохання" розглядається у статті з позицій когнітивного підходу до вивчення природи мовних одиниць. Аналізуються концептуальні засади метафоричних переносів, за допомогою яких людина як мовна особистість інтерпретує концепт "Кохання" у термінах понять, що належать до концептосфери "Культура".<br>Onomasiological space of the concept of "Love" is viewed in the article in terms of cognitive approach to studying the nature of language units. The paper considers conceptual principles of metaphoric shifts through which a man as a language personality interprets the

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Musgrave, Christopher S. A. "Development of high energy laser target materials : synthesis of low density porous polymers, and characterisation using time domain nuclear magnetic resonace." Thesis, University of St Andrews, 2014. http://hdl.handle.net/10023/7074.

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This work details the synthesis of low density porous polymers, and characterisation with an emphasis on Time Domain Nuclear Magnetic Resonance (TD-NMR). High energy laser physics utilises low density porous polymers to study astrophysical phenomena at high pressures and temperatures in the form of plasma. Low Z, low density Polymerised High Internal Phase Emulsions (PolyHIPE) and aerogels form a large part of these capabilities, however increasingly stringent laser target parameters are now required to develop new capabilities. For low density porous polymers, this demands greater control ove

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Chen, Yinghua. "Solution structure of the target recognition domain of zoocin A, an antibacterial enzyme, and the metal binding site of zoocin A." Thesis, [Tuscaloosa, Ala. : University of Alabama Libraries], 2009. http://purl.lib.ua.edu/2202.

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Jariwala, Nidhi H. "Characterization of Staphylococcal nuclease and tudor domain containing protein 1 (SND1) as a molecular target in Hepatocellular carcinoma and Non-alcoholic steatohepatitis." VCU Scholars Compass, 2017. https://scholarscompass.vcu.edu/etd/5183.

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CHARACTERIZATION OF STAPHYLOCOCCAL NUCLEASE AND TUDOR DOMAIN CONTAINING PROTEIN 1 (SND1) AS A MOLECULAR TARGET IN HEPATOCELLULAR CARCINOMA AND NON-ALCOHOLIC STEATOHEPATITIS Nidhi Jariwala, PhD A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Integrative Life Sciences Virginia Commonwealth University, 2017 Devanand Sarkar, M.B.B.S., PhD. Associate Professor, Department of Human and Molecular Genetics Virginia Commonwealth University Richmond, Virginia SND1, a subunit of the miRNA regulatory complex RISC, has been implicated as an onco

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Collins, Kelly J. "Structure-Function Analysis of the Notch Signaling CSL-KyoT2 and SPOC-NCoR Corepressor Complexes: understanding how corepressor assembly is regulated at Notch target genes." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1393236995.

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22

Pettersson, Max, and Viktor Jansson. "Predicting rifle shooting accuracy from context and sensor data : A study of how to perform data mining and knowledge discovery in the target shooting domain." Thesis, Tekniska Högskolan, Högskolan i Jönköping, JTH, Datateknik och informatik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-45396.

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The purpose of this thesis is to develop an interpretable model that gives predictions for what factors impacted a shooter’s results. Experiment is our chosen research method. Our three independent variables are weapon movement, trigger pull force and heart rate. Our dependent variable is shooting accuracy. A random forest regression model is trained with the experiment data to produce predictions of shooting accuracy and to show correlation between independent and dependent variables. Our method shows that an increase in weapon movement, trigger pull force and heart rate decrease the predicte

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Brodell, Josefin. "LA MÚSICA ES AMOR y otras metáforas conceptuales por las que vivimos : La semántica y la estructura gramatical de metáforas traducidas." Thesis, Uppsala universitet, Institutionen för moderna språk, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-216182.

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In this thesis I have combined cognitive metaphor theory, based mostly on the theories of the book Metaphors we live by by Lakoff & Johnson, with translation theory in order to try and show how the former can contribute with useful analytical tools within me- taphor translation. More specifically, my objective is to try and show how the knowled- ge of how metaphor works according to the cognitive perspective can help translating metaphors in a way that corresponds to the recommendations established by Peter Newmark (1992), i.e. try to maintain, in as much as posible, both grammatical struc

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Mervin, Lewis. "Improved in silico methods for target deconvolution in phenotypic screens." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/283004.

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Target-based screening projects for bioactive (orphan) compounds have been shown in many cases to be insufficiently predictive for in vivo efficacy, leading to attrition in clinical trials. Phenotypic screening has hence undergone a renaissance in both academia and in the pharmaceutical industry, partly due to this reason. One key shortcoming of this paradigm shift is that the protein targets modulated need to be elucidated subsequently, which is often a costly and time-consuming procedure. In this work, we have explored both improved methods and real-world case studies of how computational me

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Warell, Peter. "Metaphors of populists – A cognitive linguistic study of conceptual metaphors in political speeches by Donald J. Trump and Nigel Farage." Thesis, Umeå universitet, Institutionen för språkstudier, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-171752.

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The purpose of this thesis is to explore the use of conceptual metaphors in political speeches by Donald Trump and Nigel Farage. Conceptual metaphor theory is applied as the framework for the study. Metaphorical linguistic expressions are identified with help of the method Metaphor Identification Procedure (MIP). The conceptual metaphors giving rise to the metaphorical linguistic expressions are identified and categorized into different domains in the study. The analysis demonstrates that the use of metaphors is ubiquitous. The metaphors related to the salient domains of politics, nation, immi

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Dorison, Aude. "Le récepteur à domaine discoïdine de type 1 : un acteur majeur des pathologies rénales chroniques et aiguës." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066144/document.

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Les maladies rénales ont un impact socio-économique majeur sur la santé publique nécessitant le développement de nouvelles stratégies thérapeutiques. Le Récepteur à Domaine Discoïdine de type 1 (DDR1) est un récepteur non-intégrine des collagènes, à activité tyrosine-kinase. Son expression anormale est un facteur clé de la pathologie rénale qui promeut le développement de l’inflammation et de la fibrose.Ces travaux de thèse nous ont permis de démontrer que l'inhibition de DDR1 freinait la progression des maladies rénales dans trois modèles, dont l'un d'évolution aiguë, l'ischémie-reperfusion (

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Dorison, Aude. "Le récepteur à domaine discoïdine de type 1 : un acteur majeur des pathologies rénales chroniques et aiguës." Electronic Thesis or Diss., Paris 6, 2016. http://www.theses.fr/2016PA066144.

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Les maladies rénales ont un impact socio-économique majeur sur la santé publique nécessitant le développement de nouvelles stratégies thérapeutiques. Le Récepteur à Domaine Discoïdine de type 1 (DDR1) est un récepteur non-intégrine des collagènes, à activité tyrosine-kinase. Son expression anormale est un facteur clé de la pathologie rénale qui promeut le développement de l’inflammation et de la fibrose.Ces travaux de thèse nous ont permis de démontrer que l'inhibition de DDR1 freinait la progression des maladies rénales dans trois modèles, dont l'un d'évolution aiguë, l'ischémie-reperfusion (

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28

Baumlé, Véronique. "New insights into Bax-dependent cell death : characterization of inhibitory peptide aptamers and their targets." Thesis, Lyon, École normale supérieure, 2011. http://www.theses.fr/2011ENSL0698.

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Les aptamères peptidiques sont des protéines combinatoires capables de moduler spécifiquement une fonction de leur cible. Une sélection fonctionelle d’aptamères peptidiques capables d’inhiber la mort cellulaire Bax-dependante chez la levure et en cellules mammaifères a été effectuée. Deux aptamères peptidiques ont été sélectionnés (Apta-32 et Apta-34). L’objectif de ce travail de thèse a été de caractériser ces deux aptamères peptidiques et leur(s) cible(s) dans le contexte de la mort cellulaire Bax-dependante. La première partie est l’étude de l’Apta-34 qui cible une protéine (C34) contenant

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Turner, Kenneth James. "Higher-order filtering for nonlinear systems using symmetric tensors." Thesis, Queensland University of Technology, 1999.

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Xie, He Fang. "Understanding the interaction between xylan-binding domains and their target ligands." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324858.

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Wright, Roni H. G. "Identification of TOPBP1 chromatin modification domains and transcriptional targets." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/30970/.

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Topoisomerase II β-binding protein 1 (TopBP1) is an essential BRCT domain containing protein involved in DNA damage signalling, replication and repair. BRCT domains have the ability to bind single and double stranded DNA as well as phosphopeptides and are found within a large group of proteins involved in the DNA damage response. These domains give the proteins the ability to bind damaged DNA and change their interacting partners following DNA damage, making their role in the DNA damage response essential for efficient signal transduction and the activation of DNA damage checkpoint and repair.

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Chapman, Edwin R. "Functional domains of neuromodulin and the interaction of calmodulin with target peptides /." Thesis, Connect to this title online; UW restricted, 1992. http://hdl.handle.net/1773/6288.

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Plotkowski, Megan Lynn. "Characterization and modulation of transmembrane domain interactions in membrane protein drug-targets." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1666392021&sid=2&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Woodbury, Nathan Scott. "Representation and Reconstruction of Linear, Time-Invariant Networks." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/7402.

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Network reconstruction is the process of recovering a unique structured representation of some dynamic system using input-output data and some additional knowledge about the structure of the system. Many network reconstruction algorithms have been proposed in recent years, most dealing with the reconstruction of strictly proper networks (i.e., networks that require delays in all dynamics between measured variables). However, no reconstruction technique presently exists capable of recovering both the structure and dynamics of networks where links are proper (delays in dynamics are not required)

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Antoniadou, Eleni. "Studies on the biochemistry of the targetin domain of Lysostaphin." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411404.

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Benavides, Iglesias Alfonso. "Experimental time-domain controlled source electromagnetic induction for highly conductive targets detection and discrimination." Texas A&M University, 2003. http://hdl.handle.net/1969.1/5810.

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The response of geological materials at the scale of meters and the response of buried targets of different shapes and sizes using controlled-source electromagnetic induction (CSEM) is investigated. This dissertation focuses on three topics; i) frac- tal properties on electric conductivity data from near-surface geology and processing techniques for enhancing man-made target responses, ii) non-linear inversion of spa- tiotemporal data using continuation method, and iii) classification of CSEM transient and spatiotemporal data. In the first topic, apparent conductivity profiles and maps were st

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Webb, Stacy. "Viral Fusion Protein TM-TM Interactions: Modulators of Protein Function and Potential Antiviral Targets." UKnowledge, 2017. http://uknowledge.uky.edu/biochem_etds/30.

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Enveloped viruses, such as HIV, influenza, and Ebola, utilize surface glycoproteins to bind and fuse with a target cell membrane. This fusion event is necessary for release of viral genomic material so the virus can ultimately reproduce and spread. The recently emerged Hendra virus (HeV) is a negative-sense, single-stranded RNA paramyxovirus that presents a considerable threat to human health as there are currently no human vaccines or antivirals available. The HeV utilizes two surface glycoproteins, the fusion protein (F) and the attachment protein (G), to drive membrane fusion. Through this

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Marshall, Jolene, Eric R. LeMay, Joshua Tapp, et al. "An Analysis of the Open Architecture Warfare System Domain Model for surface time critical targets." Thesis, Monterey, California. Naval Postgraduate School, 2007. http://hdl.handle.net/10945/6933.

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This study's objective is to evaluate the Open Architecture Warfare System Domain Model (OAWSDM) against time critical targets with specific focus on command, control, and communication processes. A functional analysis of the OAWSDM was conducted and synthesized to create the Open Architecture Time Critical Target Engagement Process Model (OATCTEPM). This model represents the notional engagement cycle of a Navy cruiser. Two scenarios were developed to exercise the system: a surprise assault from a number of personal watercraft and a saturation assault in which approximately fifty craft

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Stenvi, Teddie. "An automated testing strategy targeted for efficient use in the consulting domain." Thesis, Blekinge Tekniska Högskola, Avdelningen för programvarusystem, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-2863.

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Test automation can decrease release cycle time for software systems compared to manual test execution. Manual test execution is also considered inefficient and error-prone. However, few companies have gotten far within the field of test automation. This thesis investigates how testing and test automation is conducted in a test consulting setting. It has been recognized that low test process maturity is common in customer projects and this has led to equally low system testability and stability. The study started with a literature survey which summarized the current state within the field of a

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Vallabh, Sushmitha. "Targeted Epigenetic Suppression of Th2 Cytokines Expression." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1505131225205869.

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Sala, Margaux. "Implication des récepteurs à domaine discoïdine dans la résistance à la thérapie ciblée au cours du mélanome." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0400.

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La combinaison de deux traitements, un anti-BRAF et un anti-MEK est actuellement utilisée en première ligne de traitement dans la prise en charge des patients ayant un mélanome métastatique porteur de la mutation somatique BRAF V600E. Cependant, le problème majeur dans le mélanome est l'acquisition d'une résistance cellulaire chez 80% des patients, qui est associée à une augmentation de la formation de métastases, notamment due à l'hyper-activation de la voie des MAP kinases. Or, les récepteurs à domaine discoïdine DDR1 et DDR2 sont capables d’activer cette voie de signalisation. Les DDRs sont

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Kontitsis, Michail. "Design and implementation of an integrated dynamic vision system for autonomous systems operating in uncertain domains." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0002852.

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Appleton, Caroline E. "Standard Practice in Early Intervention: Targeted Domains Within Individualized Family Service Plans." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397730621.

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Kota, Madhava Reddy, and Binod Shrestha. "Global Backprojection for Imaging of Targets Using M-sequence UWB radar system." Thesis, Högskolan i Gävle, Akademin för teknik och miljö, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-15656.

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Synthetic Aperture Radar (SAR) is an emerging technique in remote sensing. The technology is capable of producing high-resolution images of the earth surface in all-weather conditions. Thesis work describes the present available methods for positioning and imaging targets using M-sequence UWB (Ultra-Wideband) radar signals with moving antennas and SAR algorithm to retrieve position and image of the target. M-sequence UWB radar technology used as signal source for transmission and receiving echoes of target. Pseudo random binary sequence is used as a transmitted signal. These radars have an abi

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Roßbach, André Christian. "Evaluation of Software Architectures in the Automotive Domain for Multicore Targets in regard to Architectural Estimation Decisions at Design Time." Master's thesis, Universitätsbibliothek Chemnitz, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-163372.

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In this decade the emerging multicore technology will hit the automotive industry. The increasing complexity of the multicore-systems will make a manual verification of the safety and realtime constraints impossible. For this reason, dedicated methods and tools are utterly necessary, in order to deal with the upcoming multicore issues. A lot of researchprojects for new hardware platforms and software frameworks for the automotive industry are running nowadays, because the paradigms of the “High-Performance Computing” and “Server/Desktop Domain” cannot be easily adapted for the embedded systems

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PICCI, CRISTINA. "Exploitation of new pharmacological targets for neuropathic pain reliefe." Doctoral thesis, Università degli Studi di Cagliari, 2015. http://hdl.handle.net/11584/266610.

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Neuropathic pain is a complex chronic condition which affects the somatosensory system, poorly managed with the conventional treatments despite the immense advances in pain treatment strategies. Damage of peripheral nervous system, due to injury or disease, leads to abnormal responses to painful and not-painful stimuli; conventional analgesics can only alleviate pain in acute situation, and finding an effective treatment which can relief chronic neuropathic pain remains still challenging. Mammalian STOML3, a MEC-2 homologue, is a member of a large family of stomatin proteins characterized by

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Schreiber, Sabine [Verfasser]. "Targeted loss of SET domain-containing protein 5 impairs cardiac morphology and function in vivo / Sabine Schreiber." Ulm : Universität Ulm, 2019. http://d-nb.info/1177882574/34.

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Magyar, Matthew A. "A novel technique for determining the calcium-binding properties of the two domains of calmodulin in the presence of target peptides." Connect to resource, 2010. http://hdl.handle.net/1811/45465.

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GRILLO, BARBARA. "PARTNERS, TARGETS AND MODULATORS OF LSD1 IN STRESS-RESPONSE REGULATION." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/612975.

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In mammals, different forms of stress, including psychosocial stress, can affect various aspects of human health, promoting mood and anxiety disorders. However, very little is known about the mechanisms underlying the brain physiology of stress response, hindering the development of new therapeutic strategies. We uncover a role for the transcriptional corepressor Lysine Specific Demethylase-1 (LSD1) and its dominant negative splicing isoform neuroLSD1, in the modulation of emotional behavior. In the mouse hippocampus, LSD1 and neuroLSD1 interacting with the transcription factor Serum Response

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Pagano, Mario Angelo Primo. "Dismantling the aberrant signaling network in chronic lymphocytic leukemia: PP2A and SHP-1 as promising targets for drug discovery." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3426201.

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Reversible protein phosphorylation is a fundamental post-translational modification by which virtually all cellular events are regulated, enabling cells to properly respond to intra- and extracellular cues. Protein kinases and protein phosphatases are the principal factors involved in this in this dynamic process and are placed at the different levels of cellular signalling, and, albeit traditionally considered as functionally opposed to one another, not rarely act in an interplay to finely orchestrate and appropriately drive signal transduction. The imbalance of their expression and function

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