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Academic literature on the topic 'Tans Model'

Author: Grafiati

Published: 6 September 2023

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Journal articles on the topic "Tans Model"

1

Timaxian, Colin, Christoph F. A. Vogel, Charlotte Orcel, et al. "Pivotal Role for Cxcr2 in Regulating Tumor-Associated Neutrophil in Breast Cancer." Cancers 13, no. 11 (2021): 2584. http://dx.doi.org/10.3390/cancers13112584.

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Chemokines present in the tumor microenvironment are essential for the control of tumor progression. We show here that several ligands of the chemokine receptor Cxcr2 were up-regulated in the PyMT (polyoma middle T oncogene) model of breast cancer. Interestingly, the knock-down of Cxcr2 in PyMT animals led to an increased growth of the primary tumor and lung metastasis. The analysis of tumor content of PyMT-Cxcr2−/− animals highlighted an increased infiltration of tumor associated neutrophils (TANs), mirrored by a decreased recruitment of tumor associated macrophages (TAMs) compared to PyMT an

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Benson, Douglas D., Xianzhong Meng, David A. Fullerton, et al. "Activation state of stromal inflammatory cells in murine metastatic pancreatic adenocarcinoma." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 302, no. 9 (2012): R1067—R1075. http://dx.doi.org/10.1152/ajpregu.00320.2011.

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The histologic presence of macrophages (tumor-associated macrophages, TAMs) and neutrophils (tumor-associated neutrophils, TANs) has been linked to poor clinical outcomes for solid tumors. The exact mechanism for this association with worsened prognosis is unclear. It has been theorized that TAMs are immunomodulated to an alternatively activated state and promote tumor progression. Similarly, TANs have been shown to promote angiogenesis and tumor detachment. TAMs and TANs were characterized for activation state and production of prometastatic mediators in an immunocompetent murine model of pan

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3

Zhou, Zhengjun, Pengcheng Wang, Rongqi Sun, et al. "Tumor-associated neutrophils and macrophages interaction contributes to intrahepatic cholangiocarcinoma progression by activating STAT3." Journal for ImmunoTherapy of Cancer 9, no. 3 (2021): e001946. http://dx.doi.org/10.1136/jitc-2020-001946.

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BackgroundTumor-associated neutrophils (TANs) and macrophages (TAMs) can each influence cancer growth and metastasis, but their combined effects in intrahepatic cholangiocarcinoma (ICC) remain unclear.MethodsWe explored the distributions of TANs and TAMs in patient-derived ICC samples by multiplex immunofluorescent staining and tested their separate and combined effects on ICC in vitro and in vivo. We then investigated the mechanistic basis of the effects using PCR array, western blot analysis and ELISA experiments. Finally, we validated our results in a tissue microarray composed of primary t

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4

Han, Booyeon Julia, Luis I. Ruffolo, Katherine M. Jackson, et al. "Investigating the tumor-immune microenvironment in an autochthonous murine model of cholangiocarcinoma." Journal of Clinical Oncology 37, no. 8_suppl (2019): 53. http://dx.doi.org/10.1200/jco.2019.37.8_suppl.53.

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53 Background: Cholangiocarcinoma (CCA) is the most common liver malignancy within the biliary tree with increasing incidence and poor survival. Although surgical resection can be curative, prognosis remains abysmal with high rates of unresectability and recurrence, and new systemic therapies are needed. CCA tumors are characterized by an abundant inflammatory immune cell infiltrate, yet little is known about the immune dynamics underlying the disease. Here, we present a preclinical murine model of CCA for identifying potential targets susceptible to immune-based therapies. Methods: Mice with

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Ashby, F. Gregory, and Matthew J. Crossley. "A Computational Model of How Cholinergic Interneurons Protect Striatal-dependent Learning." Journal of Cognitive Neuroscience 23, no. 6 (2011): 1549–66. http://dx.doi.org/10.1162/jocn.2010.21523.

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An essential component of skill acquisition is learning the environmental conditions in which that skill is relevant. This article proposes and tests a neurobiologically detailed theory of how such learning is mediated. The theory assumes that a key component of this learning is provided by the cholinergic interneurons in the striatum known as tonically active neurons (TANs). The TANs are assumed to exert a tonic inhibitory influence over cortical inputs to the striatum that prevents the execution of any striatal-dependent actions. The TANs learn to pause in rewarding environments, and this pa

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McAteer, Emily, and Simone Pulver. "The Corporate Boomerang: Shareholder Transnational Advocacy Networks Targeting Oil Companies in the Ecuadorian Amazon." Global Environmental Politics 9, no. 1 (2009): 1–30. http://dx.doi.org/10.1162/glep.2009.9.1.1.

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Transnational advocacy networks (TANs) targeting corporations differ from those targeting states in the strategies they employ, determinants of network effectiveness, and assessments of goal achievement. This article develops a corporate boomerang model to analyze the dynamics of corporate-focused TANs. The model is used to assess two case studies of corporate-focused TANs—targeting the US-based oil corporations Chevron and Burlington Resources—active in Ecuador's Amazon region. In both TANs, corporate shareholder activists played a central role in the networks. The comparison demonstrates tha

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7

Beniwal, Angad, Saket Jain, Sumedh Shah, et al. "TAMI-38. TUMOR-ASSOCIATED NEUTROPHILS IN GLIOBLASTOMA PROMOTE THE PERIVASCULAR GLIOMA STEM-LIKE CELL NICHE VIA OSTEOPONTIN SECRETION." Neuro-Oncology 23, Supplement_6 (2021): vi206. http://dx.doi.org/10.1093/neuonc/noab196.822.

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Abstract Among clinical analyses, elevated neutrophil-lymphocyte ratio has been correlated with poor outcomes of glioblastoma patients independent of other prognostic factors. Additionally, our flow cytometric studies of primary patient samples found neutrophil percentage to be significantly higher in higher-grade glioma versus lower-grade glioma. Tumor-associated neutrophils (TANs) comprise less than 2% of the glioblastoma microenvironment. While TANs were initially considered passive bystanders due to their short-lived nature, investigation of TANs in other cancers revealed distinct pro-tumo

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Vannitamby, Amanda, Mohamed I. Saad, Christian Aloe, et al. "Aspirin-Triggered Resolvin D1 Reduces Proliferation and the Neutrophil to Lymphocyte Ratio in a Mutant KRAS-Driven Lung Adenocarcinoma Model." Cancers 13, no. 13 (2021): 3224. http://dx.doi.org/10.3390/cancers13133224.

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Tumour-associated neutrophils (TANs) can support tumour growth by suppressing cytotoxic lymphocytes. AT-RvD1 is an eicosanoid that can antagonise neutrophil trafficking instigated by ALX/FPR2 ligands such as serum amyloid A (SAA). We aimed to establish whether SAA and ALOX5 expression associates with TANs and investigate the immunomodulatory actions of AT-RvD1 in vivo. MPO-positive neutrophils were quantified in tumour blocks from lung adenocarcinoma (n = 48) and control tissue (n = 20) by IHC. Tumour expression of SAA and ALOX5 were analysed by RTqPCR and an oncogenic KrasG12D lung adenocarci

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9

Tan, Can Ozan, and Daniel Bullock. "A Dopamine–Acetylcholine Cascade: Simulating Learned and Lesion-Induced Behavior of Striatal Cholinergic Interneurons." Journal of Neurophysiology 100, no. 4 (2008): 2409–21. http://dx.doi.org/10.1152/jn.90486.2008.

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The giant cholinergic interneurons of the striatum are tonically active neurons (TANs) that respond with pauses to appetitive and aversive cues and to novel events. Whereas tonic activity emerges from intrinsic properties of these neurons, glutamatergic inputs from intralaminar thalamic nuclei and dopaminergic inputs from midbrain are required for genesis of pause responses. No prior computational models encompass both intrinsic and synaptically gated dynamics. We present a mathematical model that robustly accounts for behavior-related electrophysiological properties of TANs in terms of their

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Lad, Meeki, Angad Beniwal, Saket Jain, Sabraj Gill, and Manish Aghi. "TMIC-59. GLIOBLASTOMA INDUCES THE DIFFERENTIATION AND RECRUITMENT OF NON-CANONICAL ANTI-TUMORAL NEUTROPHILS FROM SKULL BONE MARROW." Neuro-Oncology 24, Supplement_7 (2022): vii284—vii285. http://dx.doi.org/10.1093/neuonc/noac209.1103.

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Abstract The effects of tumor-associated neutrophils (TANs) on glioblastoma biology remain poorly understood. Flow cytometric analysis of 5 newly diagnosed glioblastoma fresh tissue specimens surprisingly revealed a high fraction (21.0-34.1%) of TANs expressed MHCII, a marker of antigen-presenting cells not classically associated with neutrophils and not expressed in matched peripheral blood (PBNs). Transcriptomic profiling confirmed that patient TANs upregulated expression of MHCII subunits (HLA-DR), chaperones (HLA-DM), and costimulatory ligands (CD86/83). Ex vivo cocultures further demonstr

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