Journal articles on the topic 'Takashi Murakami'

Suvremeni umjetnik Takashi Murakami devedesetih godina prošloga stoljeća se dokazao kao jedan od najprovokativnijih i najutjecajnijih japanskih umjetnika svojega vremena. Kult njegove osobnosti je već odavno prerastao granice domovine. U umjetničkome svijetu poznat kao inovator suvremene japanske umjetnosti, uspjelo mu je promijeniti način poimanja umjetnosti unutar granica vlastite države i pozicionirati estetiku i senzibilitet japanske umjetnosti na svjetski umjetnički trg kao odgovor na postojeće uvjete i težnje postmodernoga doba. To novo je umjetničko načelo nazvao superflat. Murakami je predstavio superflat kao spoj visoke umjetnosti i pop-kulture, no istovremeno i kao istraživanje kulturno i društveno definiranih interpretacija umjetnosti u Japanu koje je potrebno nanovo vrednovati i definirati. Njegova su djela bogati amalgam simbola i značenja, koja nam daju duboki uvid u šarolikost tradicionalne i moderne japanske povijesti umjetnosti i kulture. Kratko ću predstaviti život i ključna djela Takashija Murakamija i njegov umjetnički pravac superflat. Cilj je ovoga rada pokazati i utvrditi opseg i značaj utjecaja Murakamijevih likovnih predaka na razvoj njegova umjetničkoga identiteta i izraza. Predstavit ću stilske karakteristike pojedinih likovnih škola i umjetnika iz različitih razdoblja japanske povijesti. Te iste oblikovne karakteristike ću usporedbom pojedinih djela potražiti u Murakamijevu opusu i umjetnosti superflata.

Este texto trata sobre la conexión entre los procesos creativos de creadores como Vanessa Beecroft y Viktor & Rolf, así como la colaboración entre marcas como Louis Vuitton, Takashi Murakami y Jeff Koons en un contexto de con uencia e hibridación entre arte y moda en la actualidad.

Murakami Takashi é um dos mais celebrados artistas internacionais contemporâneos. As suas exposições, realizadas nos principais museus do mundo e em lugares famosos como o Rockfeller Center ou o Palácio de Versailles, têm atraído milhões de visitantes, alimentado a popularidade do artista e criado uma legião de admiradores dentro e fora do Japão. As obras de Murakami, cuja realização conta com o trabalho conjunto de centenas de pessoas, impressionam pelas dimensões, a qualidade e a utilização de mídias digitais. Por meio de sua arte, Murakami consegue fundir a iconografia tradicional com a dos mangás, e as tendências da cultura otaku com as influências estrangeiras na sociedade japonesa do pós-guerra. Em outubro de 2015, após 14 anos de ausência da cena artística do seu país, Murakami decidiu voltar a expor em Tokyo, no Museu Mori. O resultado foi a exposição The 500 Arhats, uma série de novos trabalhos que têm como tema a arte, a religião, a morte e as limitações humanas. O título da exposição refere-se, em particular, a uma pintura de 120 metros de comprimento (uma das maiores já realizada na história da arte mundial), que foi originalmente produzida para o Estado do Qatar como forma pessoal de agradecimento do artista pelo apoio financeiro que o Japão recebeu daquele país após o Tsunami de 2011. A proposta deste artigo é analisar o significado e a importância da exposição de Murakami no contexto cultural do Japão de hoje, e, ao mesmo tempo, visa refletir sobre seu papel de artista e sua complexa relação com alguns aspectos da tradição cultural japonesa.

Under the headline of 'Japan Cool', popular culture from Japan has gained a significant role in the global market within the last decade. One of the concepts related to 'Japan Cool' is kawaii, meaning cute and sweet, both as a style and a lifestyle. Kawaii can be seen as visual trademarks in fashion, manga, animé, and many other parts of popular culture, as well as in visual arts by neo-pop artists such as Murakami Takashi and his associates. However, kawaii as a critical concept, has been flourishing in Japan since the 1980s, and has been the topic of sociological research that stresses the subversive and critical dimensions of the word. This article investigates how artworks can offer an ethnographic account of kawaii as a sign of ambiguity and thus signify important social currents in Japanese youth culture in the decade before 'soft power' became the agenda for official Japan.

The Robotics and Mechatronics Conference 2008 (ROBOMEC'08) was held at the “Big Hat” in Nagano, Japan, June 5-7, 2008, sponsored by the Robotics and Mechatronics Division of the Japan Society of Mechanical Engineers (JSME). Prof. Minoru Hashimoto of Shinshu University served as organizing chair, Prof. Takashi Kawamura of Shinshu University as general chair and Hiroki Murakami of IHI Corporation as program chair. The conference motto was “Robotics and Mechatronics for Sustainable Industrial Development.” A record-breaking 1,054 papers were presented in about 70 sessions, including Nano/Micro Fluid System and Medical and Welfare Robotics and Mechatronics. Participants numbered over 1,500, making it a great success. This special issue presents 15 papers from the conference selected from 109 outstanding presentations further narrowed to 42 before final selection for Part 1 (Vol.21, No.2). We thank the authors for their invaluable contributions and the reviewers for their time and effort. We also thank Editor-in-Chief Prof. Tatsuo Arai of Osaka University for organizing this special issue.

The Robotics and Mechatronics Conference 2008 (ROBOMEC'08) was held at the “Big Hat” in Nagano, Japan, June 5-7, 2008, sponsored by the Robotics and Mechatronics Division of the Japan Society of Mechanical Engineers (JSME). Prof. Minoru Hashimoto of Shinshu University served as organizing chair, Prof. Takashi Kawamura of Shinshu University as general chair, and Hiroki Murakami of IHI Corporation as program chair. The conference motto was “Robotics and Mechatronics for Sustainable Industrial Development.” A record-breaking 1,054 papers were presented in about 70 sessions, including Nano/Micro Fluid System and Medical and Welfare Robotics and Mechatronics. Participants numbered over 1,500, making it a great success. This special issue presents 13 papers from the conference. Of the 109 outstanding presentations recommended for submission, 42 were submitted and reviewed. Of these, 28 excellent papers have been accepted including the first 15 already published in Part 1 (Vol.21, No.2). We thank the authors for their invaluable contributions to this issue and the reviewers for their extensive time and effort. We also thank Editor-in-Chief Prof. Tatsuo Arai of Osaka University for organizing this special issue.

The article examines the collaborations of luxury brands with visual arts and its impact on the ingredients of brand identity using the example of Louis Vuitton. The purpose of this research is to investigate the impact of collaborations with visual art on luxury brand identity and find out what elements of identity are enhanced by collaborations. An online survey was conducted among luxury brand consumers. Both closed and open questions were included in the questionnaire. Totally 443 responses were received, and 295 of them were included in a representative sample of the study. The Louis Vuitton brand which systematically uses the collaborations with visual art and is one of the leaders in the application of brand artification was selected for this study. In the paper the main attention is focused on the Louis Vuitton products from the limited collections with the designs created in collaboration with the Japanese artists Takashi Murakami and Yayoi Kusama, and the American artist Jeff Koons. The modification in the Louis Vuitton brand identity caused by the collaborations was estimated on the basis of the Kapferer’s brand identity prism elements: physique, personality, culture, relationship, self-image, reflection. In accordance with the Kapferer’s brand identity prism, six hypotheses were formulated where three of them were fully confirmed and one hypothesis is partially verified. The research has demonstrated that the art collaborations with visual art enhance the intangible elements of the luxury brand identity — personality, culture and relationships but do not augment physique and self-image. This study has shown a partial impact of visual art collaboration on the luxury brand identity, however, the authors have not estimated the influence of other forms of art, for example, music. The impact of the other forms of arts may be considered in further research.

Contemporary Japanese visual artist Murakami Takashi's theory of “superflat” Japanese arts and culture is nationalist and masculinist. However, women artists—including Yanagi Miwa and the performers of the Takarazuka Revue and Kegawa-zoku—use two-dimensional aesthetics to challenge the nationalist and masculinist construction of Japanese womanhood.

Totsune K, Takahashi K, Murakami O, Satoh F, Sone M, Ohneda M. Miura Y. Mouri T. Immunoreactive brain natriuretic peptide in human adrenal glands and adrenal tumors. Eur J Endocrinol 1996;135:352–6. ISSN 0804–4643 The presence of brain natriuretic peptide (BNP) in tissues of human adrenal glands and adrenal tumors was investigated by radioimmunoassay. Immunoreactive BNP concentrations were 0.203 ± 0.061 pmol/g wet tissue (mean ± sem) in normal parts of adrenal glands (cortex and medulla. N = 8), 0.205 ± 0.037 pmol/g wet tissue in pheochromocytomas (N = 8), 0.230 ± 0.062 pmol/g wet tissue in aldosteronomas (N = 11) and 0.180 ± 0.054 pmol/g wet tissue in adrenocortical adenomas with Cushing's syndrome (N = 4). Sephadex G-50 superfine column chromatography and reverse-phase high-performance liquid chromatography showed that most (> 70%) of the immunoreactive BNP in the normal part of adrenal glands was eluted in the position of human BNP-32. Sephadex G-50 superfine column chromatography of immunoreactive BNP in the pheochromocytoma and aldosteronoma showed four peaks: one in the position ofγ-BNP, one in the position of BNP-32, one between γ-BNP and BNP-32 and one in the smaller molecular weight region. The present study has shown that immunoreactive BNP is present both in normal human adrenal glands and in adrenal tumors. Multiple molecular forms of BNP were found to be present in the tumor tissues of pheochromocytoma and aldosteronoma. Kazuhiro Takahashi. Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, 2–1 Seiryo-machi, Aoba-ku. Sendai 980–77, Japan

Aluminum–silicon alloys are commonly used in die-cast and additively manufactured (AM) light-weight components due to their good processability and high strength-to-weight ratio. As both processing routes lead to the formation of defects such as gas and shrinkage porosity, a defect-sensitive design of components is necessary for safe application. This study deals with the fatigue and crack propagation behavior of die-cast alloy AlSi7Mg0.3 and additively manufactured alloy AlSi12 and its relation to process-induced defects. The different porosities result in significant changes in the fatigue stress-lifetime (S–N) curves. Therefore, the local stress intensity factors of crack-initiating defects were determined in the high and very high cycle fatigue regime according to the fracture mechanics approach of Murakami. Through correlation with fatigue lifetime, the relationship of stress intensity factor (SIF) and fatigue lifetime (N) could be described by one power law (SIF–N curve) for all porosities. The relationship between fatigue limit and defect size was further investigated by Kitagawa–Takahashi (KT) diagrams. By using El Haddad’s intrinsic crack length, reliable differentiation between fracture and run out of the cast and AM aluminum alloys could be realized. SIF–N curves and KT diagrams enable a reliable fatigue design of cast and AM aluminum alloys for a finite and infinite lifetime.

ABSTRACT Our previous study by Murakami N, Mori T, Nakamura S, Yoshimoto S, Honma Y, Ueno T, Kobayashi K, Kashihara T, Takahashi K, Inaba K, Okuma K, Igaki H, Nakayama Y, Itami J. (J Radiat Res. 2019 Jul 30. pii: rrz053. doi: 10.1093/jrr/rrz053. [Epub ahead of print]) showed that strong expression of epithelial cell adhesion molecule (EpCAM) was associated with radiation resistance in head and neck squamous cell cancer patients (SCC). In this study, the prognostic impact of histopathologic features including EpCAM for nasopharyngeal cancer (NPC) patients was investigated. Since 2009, our institution has performed chemoradiation for locally advanced NPC patients with intensity modulated radiation therapy (IMRT). Tri-weekly adjuvant cisplatin (CDDP, 80 mg/m2) was administered concurrently with definitive radiation therapy 70 Gy in 35 fractions. One month after radiation therapy, adjuvant chemotherapy of three cycles of CDDP/5 fluorouracil (5-FU) was administered. Using a pretreatment biopsy specimen, EBV-encoded small RNA in situ hybridization (EBER-ISH), EpCAM, p16 and p53 were assessed by immunohistochemical analysis. Between May 2009 and September 2017, 51 NPC patients received definitive radiation therapy. Five, 13, 17 and 16 patients were staged as I, II, III and IV, respectively. The median follow-up period for alive patients was 31.1 months (12.4–109.7 months). Three-year overall survival (OS), progression-free survival (PFS) and locoregional control (LRC) were 87.1, 57.1 and 85.7%, respectively. EpCAM, p16 and p53 were not associated with PFS, OS nor LRC. Three-year PFS for patients with keratinizing and non-keratinizing SCC were 25 and 60.5%, respectively (P = 0.033, hazard ratio 4.851 (95% confidence interval 1.321–17.814)).Prognosis of NPC patients with keratinizing SCC was worse than non-keratinizing SCC patients, suggesting a biological difference between the two types of tumor.

Background:Tacrolimus (TAC), an immunosuppressant, can be used in second-line maintenance therapy of interstitial lung disease (ILD) in patients with dermatomyositis (DM) [1]. In Japan, TAC is approved for DM-ILD and often used as induction therapy for severe cases, especially in patients with anti-MDA5-Ab (melanoma differentiation-associated gene 5 antibody) positive, in combination with glucocorticoids (GC) and intravenous cyclophosphamide (IVCY). Some studies reported the clinical efficacy of initial high-trough level TAC for DM-ILD in combination with GC and IVCY [2]. Adjustment to target concentration of TAC in early stage of treatment is important for controlling disease activity. The concentration of TAC depends on genetic polymorphisms in cytochrome P450 (CYP) 3A5 enzyme expression and several reports showed that the bioavailability and concentration of TAC in patients with a CYP3A5 *1 allele (*1) was lower than those with a CYP3A5 *3/*3 (*3/*3) [3].Objectives:To examine the usefulness of CYP3A5 polymorphisms in decision of initial dose to achieve the target concentration of TAC and to evaluate the clinical efficacy in patients of DM-ILD who achieved the enough concentration of TAC in early stage of treatment.Methods:We investigated CYP3A5 polymorphisms and TAC concentration in 9 patients of DM-ILD without renal dysfunction (eGFR>60). TAC was taken after both morning and evening meals and blood samples were taken 12h after TAC administration. The blood concentration of TAC normalized to the corresponding dose per body weight (C/D, ng/ml per mg/kg) was analyzed according to genetic variation in CYP3A5. Based on the retrospective analyzation, we chose proper dose of TAC in initial treatment for an anti-MDA5-Ab positive DM-ILD patient, whose genotype was *3/*3.Results:The C/D value in the *3/*3 group (n=6) was 154.6±25.6, which was significantly higher than that in the *1 group (n=3;79.0±2.8; P =0.028). When the target concentration was set at 5-10 ng/ml, the required dose was (0.0316 to 0.0633) mg/kg in the *1 group and (0.0162 to 0.0324) mg/kg in the *3/*3 group. The *1 group needs more dose than that of the *3/*3 group to achieve the same target trough of TAC, suggesting that the examination of CYP3A5 genotype is useful for deciding initial dose of TAC (Fig.1). We started TAC 6mg/day with setting target concentration at 15-20 ng/ml to a *3/*3 patient of DM-ILD with anti-MDA5-Ab positive, resulting in good clinical course with making rapid attainment of target concentration in early stage of treatment (Fig.2).Conclusion:To examine the CYP3A5 genotype is valuable for deciding the initial dose of TAC, especially in patients who need achievement to target concentration rapidly.References:[1]Oddis CV and Aggarwal R. Nat Rev Rheumatol 2018;14(5):279-89.[2]Suzuka T et al. Int J Rheum dis 2019;22: 303-13.[3]Y. Muraki et al. Exp Ther Med 2018;15:532-38.Acknowledgments:noneDisclosure of Interests:motoko katayama: None declared, Shinji Horibata: None declared, Soshi Takahashi: None declared, Miho Takahashi: None declared, Saki Mukohara: None declared, Norihiko Amano: None declared, Katsuyuki Yoshida: None declared, Saori Hatachi: None declared, Kennosuke Yorifuji: None declared, Shunichi Kumagai Grant/research support from: Astellas, Chugai, Mitsubishi Tanabe Co.Ltds, Consultant of: Sysmex Co.Ltd, Speakers bureau: many companies

Nuclear magnetic resonance (NMR) is widely used in the physical, chemical, and biological sciences. However, conventional NMR techniques based on induction-detection have drawbacks of low-sensitivity and the need of a relatively large sample. It is not suitable to investigate single or double layers (or their nanostructure), which is essential in studying quantum Hall (QH) effects. In this presentation, I discussed a resistively-detected technique to overcome the low-sensitivity limitation of conventional NMR and its application to QH systems. Resistively-detected nuclear-spin-based measurements rely on enhanced interactions between electron and nuclear spins at the degenerate point of different electron-spin states. For example, at the ν = 2/3 degenerate point in a AlGaAs / GaAs system,1–3 nuclear-spin polarization far beyond the thermal equilibrium is generated using current flow (dynamic nuclear-spin polarization). Moreover, nuclear-spin polarization can be detected as enhanced resistance, which is proportional to the magnetization, Mz, of nuclear spins.2 It should be stressed that the special states of ν = 2/3 are needed for dynamic nuclear-spin polarization and Mz detection, but we can apply NMR spectrum and nuclear-spin relaxation (T1 time) measurements for any state we want to estimate. These nuclear-spin-based measurements were successfully applied to characterize QH systems, especially their electron-spin features, using single and double layer systems where characteristics are controlled electrically by the gate biases. For a single layer, we could clarify skyrmion,2 spin-polarization of composite fermion,4 and enhanced spin-orbit interactions in a strongly asymmetric confinement.5 Exciting phases, like a canted antiferromagnetic phase, were studied in a double layer QH system with a total filling factor of 2 (Refs. 6, 7). The low-frequency mode was sensitively detected by monitoring T1, reflecting correlated electron spin features.7 The clear observations of the characteristics, which are difficult to detect in conventional transport and optical measurements, make nuclear-spin-based measurement combined with resistance-detection a versatile and powerful tool for studying QH physics. Possible extensions of such measurements to semiconductor nanosystems were also discussed. The experiments discussed here were mainly carried out at NTT Basic Research Laboratories in collaboration with K. Muraki, N. Kumada, K. Takashina, K. Hashimoto, S. Watanabe and G. Yusa. Note from Publisher: This article contains the abstract only.

Background:Though several studies showed the efficacy of tacrolimus (TAC) in patients with rheumatoid arthritis (RA) in a dose-depending manner [1], the relationship between efficacy and concentration of TAC remained unclear. Genetic polymorphisms of cytochrome P450 (CYP) 3A5 were reported not only to play an important role in pharmacokinetics of TAC but also to have an influence on clinical outcomes in patients of rheumatic diseases. Several reports showed that the blood concentration of TAC in patients with a CYP3A5 *1 allele (EX, expressor) was lower than that of patients with a CYP3A5 *3/*3 (NEX, non-expressor) [2].Objectives:To assess the relationship between efficacy and concentration of TAC in patients with RA, and to examine the usefulness of CYP3A5 genotype screening to detect outpatients suitable for TAC treatment.Methods:We examined the relationship between disease activity score (DAS) 28-CRP and concentration of TAC in patients with RA. TAC was taken after the evening meal and blood samples were taken 12±4h after TAC administration. Next we investigated the relationship between genotype frequencies of CYP3A5 and concentration of TAC in patients with rheumatic disease without having renal dysfunction (eGFR<60) and also investigated the influence of concomitant drugs, such as strong inhibitors of CYP3A4/5 or metabolized by CYP3A4/5, to C/D value in each NEX and EX group. The blood concentration of TAC normalized to the corresponding dose per body weight (C/D, ng/ml per mg/kg) was analyzed according to genetic variation in CYP3A5. Furthermore we investigated the relationship between genotype frequencies of CYP3A5 and concentration of TAC in patients with rheumatic disease at first visit and second visit after starting TAC administration to assess the possibility for making rapid attainment of enough concentrations of TAC in early stage of treatment.Results:The concentration of TAC tended to be negatively correlated with the disease activity of RA. The C/D value in the NEX group (n=16) was 124.7±62.1, which was significantly higher than that in the EX group (n=23; 67.7±29.8;P<0.001). When comparing patients using concomitant drugs which are strong inhibitors of CYP3A4/5 or metabolized by CYP3A4/5 with patients not using those drugs, the each C/D value of NEX group was 122.9±52.3 (n=9) and 126.9±77.3 (n=7), and that of EX group was 71.3±32.2 (n=12) and 63.8±28.0 (n=11). There were no significant differences between these groups. In NEX group, when comparing concentration of TAC at first visit and second visit after starting TAC administration, the each concentration of TAC was 3.14±2.06 ng/ml and 3.80±2.20 ng/ml in NEX group (n=10), and that of TAC was 1.82±0.82 ng/ml and 2.69±1.52 ng/ml (n=11) in EX group (Figure).Conclusion:TAC showed efficacy in patients with RA in a concentration-dependent manner. EX patients may be impossible to achieve enough concentration of TAC even though using TAC of 3mg/day, approved dose for patients with RA in Japan, and NEX patients could make rapid attainment of enough concentrations of TAC in early stage of treatment, suggesting that we should consider induction of TAC only in NEX outpatients. Furthermore, drugs only slightly affected concentration of TAC in this study, suggesting that we can use TAC without any special attention to concomitant drugs.References:[1]Furst DE et al. Arthritis Rheum 2002;46:2020-28.[2]Y. Muraki et al. Exp Ther Med 2018;15:532-38.Acknowledgments:noneDisclosure of Interests:Soshi Takahashi: None declared, Shinji Horibata: None declared, Saori Hatachi: None declared, Miho Takahashi: None declared, Motoko Katayama: None declared, Saki Mukohara: None declared, Norihiko Amano: None declared, Katsuyuki Yoshida: None declared, Kennosuke Yorifuji: None declared, Shunichi Kumagai Grant/research support from: Astellas, Chugai, Mitsubishi Tanabe Co.Ltds, Consultant of: Sysmex Co.Ltd, Speakers bureau: many companies

This article provides the review of the medical use of pH- and temperature-sensitive polymer hydrogels. Such polymers are characterised by their thermal and pH sensitivity in aqueous solutions at the functioning temperature of living organisms and can react to the slightest changes in environmental conditions. Due to these properties, they are called stimuli-sensitive polymers. This response to an external stimulus occurs due to the amphiphilicity (diphilicity) of these (co)polymers. The term hydrogels includes several concepts of macrogels and microgels. Microgels, unlike macrogels, are polymer particles dispersed in a liquid and are nano- or micro-objects. The review presents studies reflecting the main methods of obtainingsuch polymeric materials, including precipitation polymerisation, as the main, simplest, and most accessible method for mini-emulsion polymerisation, microfluidics, and layer-by-layer adsorption of polyelectrolytes. Such systems will undoubtedly be promising for use in biotechnology and medicine due to the fact that they are liquid-swollen particles capable of binding and carrying various low to high molecular weight substances. It is also important that slight heating and cooling or a slight change in the pH of the medium shifts the system from a homogeneous to a heterogeneous state and vice versa. This providesthe opportunity to use these polymers as a means of targeted drug delivery, thereby reducing the negative effect of toxic substances used for treatment on the entire body and directing the action to a specific point. In addition, such polymers can be used to create smart coatings of implanted materials, as well as an artificial matrix for cell and tissue regeneration, contributing to a significant increase in the survival rate and regeneration rate of cells and tissues. References 1. Gisser K. R. C., Geselbracht M. J., Cappellari A.,Hunsberger L., Ellis A. B., Perepezko J., et al. 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Concentrations of 16 polycyclic aromatic hydrocarbons (PAHs) were determined in settled house dust and road dust samples collected from a core urban area of Hanoi. Levels of PAHs ranged from 830 to 3500 (median 2000) ng/g in house dust, and from 1400 to 4700 (median 1700) ng/g in road dust. Concentrations of PAHs in dust samples of this study were within the moderate range as compared with those from other countries in the world. Toxic equivalents to benzo[a]pyrene (BaP-EQs) in our samples ranged from 81 to 850 (median 330) ng BaP-EQ/g with principal contributors as BaP and dibenz[a,h]anthracene, which accounted for 69% to 93% of BaP-EQs. In almost all the samples, proportions of high-molecular-weight PAHs (HMW-PAHs with 4–6 rings) were higher than those of low-molecular-weight PAHs (LMW-PAHs with 2–3 rings), suggesting emission sources from combustion processes rather than direct contamination by petrogenic sources. 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Introdução: A tecnologia CAD/CAM possui múltiplas aplicações protéticas, incluindo a prótese total. Objetivos: realizar uma revisão de literatura sobre a aplicabilidade dos sistemas CAD/CAM na fabricação de próteses totais, a fim de elucidar as propriedades das próteses confeccionadas através dessa tecnologia e as características desse sistema. Metodologia: A busca por artigos científicos que contemplassem o tema foi realizada através das bases de dados PUBMED e SCIELO, sem restrição de período. Foi feita a análise dos títulos e resumos e em seguida o acesso ao texto completo. Resultados: Dentre as características do sistema CAD/CAM, os estudos citaram menor necessidade de consultas e tempo clínico. É preciso conhecimento da tecnologia pelo cirurgião-dentista e o maior custo laboratorial é uma das desvantagens de sua utilização. Quanto às propriedades, observa-se a redução da rugosidade e porosidade, assim como da adesão de Candida albicans à base da prótese e teor de monômero residual. Maior dureza de superfície é verificada em comparação com as próteses totais convencionais. Conclusão: Menor número de consultas e tempo clínico são características do uso do sistema CAD/CAM em prótese total. Maior dureza da prótese e redução da rugosidade, porosidade, adesão de C. albicanse do teor de monômero residual são propriedades que as próteses totais apresentam quando confeccionadas por essa tecnologia.Descritores: Odontologia; Prótese Total; Projeto Auxiliado por Computador.ReferênciasAlbero A, Pacual A, Camps I, Grau-Benitez M. Comparative characterization of a novel cad-cam polymer-infiltrated-ceramic-network. J Clin Exp Dent. 2015;7(4):e495-500.Janeva N, Kovacevska G, Janev E. Complete Dentures Fabricated with CAD/CAM Technology and a Traditional Clinical Recording Method. 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The level of residual monomer in injection molded denture base materials. J Korean Acad Prosth. 2003;41(3):360–8.Kattadiyil MT, Goodacre CJ, Baba NZ. CAD/CAM complete dentures: a review of two commercial fabrication systems. J Calif Dent Assoc. 2013;41(6):407–16.Consani RLX, Pucciarelli MGR, Mesquita MF, Nogueira MC, Barao VA. Polymerisation cycles on hardness and surface gloss of denture base. Int J Contemp Dent Med Rev. 2014;2014:1–6.Nakayama M, Takagi N. Methods for manufacturing dental resin block. US:2016.Murakami N, Wakabayashi N, Matsushima R, Kishida A, Igarashi Y. Effect of high-pressure polymerization on mechanical properties of PMMA denture base resin. J Mech Behav Biomed Mater. 2013;20:98-104.Al-Fouzan AF, Al-Mejarad Lamya A, Albarrag AM. Adherence of Candida to complete denture surfaces in vitro: A comparison of conventional and CAD/CAM complete dentures. J Adv Prosthodont. 2017;9(5):402-8.Digholkar S, Madhav VN, Palaskar J. 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O objetivo do presente artigo foi relatar uma forma de confecção de prótese total utilizando a clonagem da prótese provisória com a finalidade de reduzir as etapas do tratamento. Paciente desdentada total superior e classe I de Kennedy inferior compareceu ao consultório apresentando inflamação severa do tecido periodontal, mobilidade grau III de todos os dentes e supuração à sondagem. Optou-se por realizar prótese total superior convencional e realização das exodontias dos dentes remanescentes, seguida de prótese total provisória e como tratamento definitivo mandibular uma prótese total convencional. Na primeira sessão foi realizada a reavaliação dos tecidos bucais, moldagem da prótese total superior para obter o modelo antagonista, seleção da cor do dente, registro para montagem no articulador semi-ajustável e a clonagem da prótese total inferior provisória. Após polimerizada, a réplica em resina acrílica incolor foi ajustada em boca e realizada a moldagem de borda com godiva em bastão, seguida da moldagem funcional com silicone de condensação. Ambos modelos foram montados no articulador para montagem dos dentes artificiais. A prova estética e funcional foi realizada na segunda consulta e na terceira a prótese foi instalada junto com as instruções de uso e higiene oral. Os controles foram realizados após 24 horas, 3, 7 e 14 dias. O uso de uma técnica alternativa para confecção de uma moldeira individual pode reduzir o tempo clinico, trazendo assim vantagens tanto para o paciente como para o profissional, desde que haja um bom planejamento e conhecimento da técnica.Descritores: Prótese Total; Técnica de Moldagem Odontológica; Materiais para Moldagem Odontológica.ReferênciasEmami E, Souza RF, Kabawat M, Feine JS. The impact of edentulism on oral and general health. Int J Dent. 2013;2013:498305Williams SE, Slice DE. 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