Journal articles on the topic 'Tablets (Medicine)'
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Mubeen, Ahamed Mueen, Atchaya A, Ilakiya S, Rasitha Banu U, Rojamani K, and Vijayalakshmi S. "Comparative standardization studies of marketed Polyherbal tablets." International Journal of Multidisciplinary Research and Growth Evaluation 4, no. 2 (2023): 346–50. http://dx.doi.org/10.54660/.ijmrge.2023.4.2.346-350.
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Siddha and Ayurvedha is one of the oldest traditional systems of medicine in the world. There are different formulations which are adequately increase delivery of the drug to our body sites; one of basic formulation is tablet. Tablet is one of the conventional formulations in solid oral dosage form, which are usually used in traditional system of medicines and allopathic medicines. Allopathic formulations like tablets usually maintaining their standards based on the various pharmacopoeia but Ayurvedhic and Siddha proprietary medicines shows lots of troubles in their standardization parameters, why because they consist of multiple herbal crude drugs in one formulation, so it should be prescribed with proper standardization parameters. The present work deals with to evaluation two marketed formulation by performing basic quality control parameters of tablets such as Organoleptic properties, Weight variation, Hardness, Friability, Disintegration of herbal tablets {Alsactil [A] and Alsarex [B]} From the analysis of above parameters, results was observed and all the parameters of both drugs passes the test, within the reference values.
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Bracken, Louise, Emma McDonough, Joanne Shakeshaft, Fiona Wilson, Udeme Ohia, Mohamed A. Alhnan, Rober Habashy, Robert Forbes, and Matthew Peak. "SP8 Creating acceptable tablets 3D (CAT 3D): a feasibility study to evaluate the mouthfeel of 3D printed tablets in children and young people." Archives of Disease in Childhood 105, no. 9 (August 19, 2020): e5.1-e5. http://dx.doi.org/10.1136/archdischild-2020-nppg.8.
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AimTo evaluate the feasibility of a study investigating the mouthfeel of different sized 3D printed placebo solid dosage forms (SDFs) in children and young people (CYP) aged 4–12 years.MethodAll participants in the CAT 3D Study had previously participated in the Creating Acceptable Tablets (CAT) Study, a feasibility study which assessed the swallowability and acceptability of different sized placebo tablets, and therefore only attempted to swallow one 3D printed tablet. If the participant had successfully swallowed all three tablet sizes in the CAT Study (6 mm, 8 mm, 10 mm) they were then randomised to receive any of the 3D printed tablets – 6 mm, 8 mm or 10 mm diameter. If a participant had not successfully swallowed all tablet sizes, they were allocated a 3D printed tablet of equal size to the largest tablet they had successfully swallowed in the CAT Study. Following informed consent, participants were shown a short video demonstrating how to swallow a tablet. Participants were then provided with the sample 3D tablet and 150 mL of still water in a cup. The volume of water required to swallow the tablet was measured, and further water was provided, where requested. The researcher observed and recorded the child’s facial expressions as they swallowed the tablet1, and an internal inspection of the mouth was conducted by the researcher to identify any residue or non-swallowed tablet.2 The participants assessed the swallowability, acceptability, mouthfeel and taste of the sample using a 5-point hedonic facial scale on a participant questionnaire. Faces 1–3 on the hedonic scale were deemed acceptable to the participant. The participants were also asked if the 3D printed tablet was a medicine, would they be willing to take it every day. In addition, they were asked which tablet felt better in the mouth as a comparison of mouthfeel between the GMP manufactured coated tablets (CAT study tablets) and the 3D printed tablets.ResultsA total of 30 participants were recruited to the CAT 3D Study, 87% of whom successfully swallowed the 3D printed tablet that they attempted to take. Attributes of the 3D printed tablets were scored as acceptable by the following percentage of participants – swallowability (80%), mouthfeel/texture (87%), volume (80%), acceptability (83%) and taste (93%). 77% of children advised they would be happy to take the tablet every day if it were a medicine. Participants were also asked which tablets felt better in the mouth – the CAT tablets or the 3D printed CAT 3D tablets, and the most popular response was that both felt ok (43%).ConclusionsThe data from this study shows that 3D printed SDFs may be a suitable dosage form for children aged 4–12 years. The results from this feasibility study will be used to inform a larger, definitive study looking at the mouthfeel of 3D printed tablets in children.ReferencesZeinstra GG, Koelen MA, Colindres D, et al. Facial expressions in school-aged children are a good indicator of ‘dislikes’, but not of ‘likes’. Food Quality and Preference 2009 December 2009; 20:620–624.Klingmann V, Spomer N, Lerch C, et al. Favorable acceptance of mini-tablets compared with syrup: a randomized controlled trial in infants and preschool children. The Journal of Pediatrics 2013 December 2013;163:1728–1732.e1.
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Wang, Yifei, Zhisheng Wu, Zhaoyi Wang, Manfei Xu, Xinyuan Shi, and Yanjiang Qiao. "Rapid analysis of spatial distribution of PVPP and hardness of Yinhuang dispersible tablets by NIR-CI." Journal of Innovative Optical Health Sciences 09, no. 02 (March 2016): 1550016. http://dx.doi.org/10.1142/s1793545815500169.
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The present study aimed at investigating the relationship between tablet hardness and homogeneity of different Yinhuang dispersible tablets by near-infrared chemical imaging (NIR-CI) technology. The regularity of best hardness was founded between tablet hardness and the spatial distribution uniformity of Yinhuang dispersible tablets. The ingredients homogeneity of Yinhuang dispersible tablets could be spatially determined using basic analysis of correlation between analysis (BACRA) method and binary image. Then different hardnesses of Yinhuang dispersible tablets were measured. Finally, the regularity between tablet hardness and the spatial distribution uniformity of Yinhuang dispersible tablets was illuminated by quantifying the agglomerate of polyvinyl poly pyrrolidone (PVPP). The result demonstrated that the distribution of PVPP was unstable when the hardness was too large or too small, while the agglomerate of PVPP was smaller and more stable when the best tablet hardness was 75[Formula: see text]N. This paper provided a novel methodology for selecting the best hardness in the tabletting process of Chinese Medicine Tablet.
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Shyrko, A. Yu, M. M. Vasenda, L. I. Будняк, and O. O. Pokotylo. "The choice of excipients to obtain tablets based on the Primula denticulate Smith. Extract by wet granulation." Ukrainian biopharmaceutical journal, no. 1(66) (April 12, 2021): 4–9. http://dx.doi.org/10.24959/ubphj.21.296.
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Introduction. Herbal medicines are increasingly being used in the treatment of various diseases. Significant number of resources, high-level availability and the possibility of cultivation have provided high prospects of plant raw materials in the development of new herbal medicines. Primula denticulate Smith. is one of the most interesting medicinal plant raw materials source in modern medicine and pharmacy with the wide spectrum of pharmacotherapeutic action, that is mainly used only in traditional medicine. Thus, nowadays the development of new and effective medicines based on Primula denticulate Smith. in tablet dosage form is the topical task of pharmacy.
The aim of the work. To study the influence of excipients on the pharmacotechnological parameters of tablets with Primula denticulate Smith, are obtained by wet granulation method and to substantiate the choosing of the best excipients by the method of mathematical planning of the experiment.
Materials and Methods. It was used a self-prepared dense extract of Primula denticulate Smith. and excipients, which are complied with the requirements of State Pharmacopoeia of Ukraine in terms of pharmaco-technological quality parameters, for developing tablets. The hyper Greek-Latin square 4x4 was used to study the four qualitative factors.
Results and Discussion. In the course of the experiment, it was determined the dependence of pharmacotechnological parameters (friability, resistance to crushing and disintegration of tablets) on type of excipients. It was selected excipients with the optimal pharmaco-technological parameters for further research the tablets quality.
Conclusions.
According to the method of mathematical planning of the experiment, it’s chosen the optimal excipients for obtaining tablets based on dense extract of Primula denticulate Smith. Considering the investigated pharmaco-technological properties (friability, resistance to crushing and disintegration of tablets) the qualitative composition of excipients for obtaining tablets by the method of wet granulation was determined: Avicel PH - 105 and MCC 101, croscarmellose sodium, colloidal anhydrous silicon dioxide, magnesium stearate and Prosolv 90.
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Bhatia, Ritika, Rakesh Goyal, and Dilip Agarwal. "Process Validation of Paracetamol tablet as per ICH guidelines." International Journal of Medical and Biomedical Studies 7, no. 6 (June 12, 2023): 11–23. http://dx.doi.org/10.32553/ijmbs.v7i6.2713.
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Process validation is an integral part of pharmaceutical manufacturing, ensuring that tablets are consistently produced with quality and efficacy in line with regulatory requirements. The International Council for Harmonization ICH) provides guidelines for the systematic validation of manufacturing processes. This research article presents a comprehensive study on process validation for Paracetamol tablets following the ICH guidelines. The article focuses on various aspects of the validation process, including process design, qualification, and continued process verification, with specific emphasis on Paracetamol tablet manufacturing. Experimental studies were conducted to characterize the critical process parameters and assess their impact on the tablet's quality attributes. The article also discusses the use of statistical analysis techniques for data evaluation and demonstrates the establishment of a robust validation protocol for Paracetamol tablet manufacturing. Through the application of the ICH guidelines, this research contributes to ensuring the consistency and reliability of Paracetamol tablets, enhancing patient safety and meeting regulatory expectations.
Keywords: Process validation, ICH guidelines, Critical process parameters, Critical Process Attribution, Statistical analysis, and validation protocol;
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Sanada, Tomoko, Myu Ohnishi, Naoko Yoshida, Kazuko Kimura, and Hirohito Tsuboi. "Quality assessment of Diflucan® tablets distributed online: Diflucan® distributed online." Medicine Access @ Point of Care 5 (January 2021): 239920262110020. http://dx.doi.org/10.1177/23992026211002089.
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Background: Falsified medical products have been reported worldwide. Falsified medicines with poor quality are a potential health hazard. Some Internet sites advertise fluconazole (Diflucan®), an antifungal medicine used to treat deep mycoses, as “female Viagra®.” Aim: The aim of this study was to investigate the authenticity and quality of Diflucan® tablets distributed on the Internet. Methods: We ordered Diflucan® tablets via the Internet and evaluated them by visual observation, authenticity investigation, quality evaluation (quantity of the active pharmaceutical ingredient, content uniformity, and dissolution), and near-infrared and Raman scattering spectroscopy. Results: We obtained 11 samples of Diflucan® tablets from all 11 Japanese Internet sites identified in our search. Of 11 sites, 7 advertised fluconazole as having effects on female sexual function. Ten of the Diflucan® samples were confirmed as genuine and one sample was falsified. The genuine Diflucan® samples met the specifications of all quality evaluations. The packaging, size, and color of the falsified Diflucan® sample obtained in this study differed from the authentic Diflucan® tablet. The falsified Diflucan® sample obtained in this study did not contain fluconazole and instead contained what appeared to be sildenafil citrate. The spectra of the falsified Diflucan® tablet obtained in this study differed from the authentic Diflucan® tablet in near-infrared and Raman scattering spectroscopy. Conclusion: We confirmed that one falsified Diflucan® tablet was distributed online. Thus, continued measures against falsified medicines are required.
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Karmakar, Palash, and Md Golam Kibria. "In-vitro comparative evaluation of quality control parameters between paracetamol and paracetamol/caffeine tablets available in Bangladesh." International Current Pharmaceutical Journal 1, no. 5 (April 7, 2012): 103–9. http://dx.doi.org/10.3329/icpj.v1i5.10282.
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Paracetamol is a widely used non-prescription analgesic and antipyretic medicine. The study was conducted to assess the comparative in-vitro quality control parameters through the evaluation of weight variation, hardness, friability, disintegration time and dissolution profile between the commercially available tablet brands of paraceta-mol and paracetamol/caffeine combination in Bangladesh. Tablets of five top level manufacturers those have both of the formulations were evaluated in two groups. Both similarities and dissimilarities were found between the groups. All tablets either paracetamol (1.07 to 2.14%) or paracetamol/caffeine (0.98 to 2.09%) showed acceptable weight variation and friability (below 1%). Formulations were somewhat different in their hardness, disintegration time and dissolution profile. All tablets of paracetamol/caffeine were found harder than paracetamol tablets of the same manufacturer. 1 out of 5 for paracetamol and 3 out of 5 for paracetamol/caffeine tablets exceeded the limit of tablet hardness or crushing strength. The disintegration time in 0.1N HCl of paracetamol tablet brands (24 seconds to 4 minutes 52 seconds) were less than the paracetamol/caffeine (6 minutes 33 seconds to 17 minutes 43 seconds) brands. On the other hand in phosphate buffer, pH 7.4, paracetamol/caffeine tablets dissolved quickly and showed better release profile than tablets containing only paracetamol. It can be concluded that standard quality control parameters always should be maintained not only for paracetamol or its combination but also for all kinds of medicine for getting better drug products.DOI: http://dx.doi.org/10.3329/icpj.v1i5.10282International Current Pharmaceutical Journal 2012, 1(5): 103-109
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Bracken, Louise, Emma McDonough, Samantha Ashleigh, Fiona Wilson, Joanne Shakeshaft, Udeme Ohia, Punam Mistry, et al. "Can children swallow tablets? Outcome data from a feasibility study to assess the acceptability of different-sized placebo tablets in children (creating acceptable tablets (CAT))." BMJ Open 10, no. 10 (October 2020): e036508. http://dx.doi.org/10.1136/bmjopen-2019-036508.
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ObjectiveFeasibility study to investigate the acceptability of different-sized placebo tablets in children aged 4–12 years.Design and settingClinical Research Facilities, inpatient wards and outpatient clinics within a Regional Paediatric Hospital and/or District General Hospital. Healthy children and National Health Service (NHS) patients were asked to swallow three placebo tablets: 6 mm, 8 mm and 10 mm, smallest to largest. The researcher observed children’s facial expressions and behaviours on swallowing and measured the volume of water consumed. Participants completed a questionnaire about the overall acceptability; including swallowability, taste and volume of water consumed. For analysis, participants were stratified by age: 4–8 years and 9–12 years.ResultsThe feasibility study led to an estimated recruitment rate of 0.8% for NHS inpatients and 211 healthy children over a 1-year period. In total, 55 participants were recruited, 30 to the younger group, of which 77% had never taken a tablet before. 84% of the 25 older children had previously taken a tablet. All participants attempted to swallow the smallest sized tablet. The children aged 4–8 years found the larger tablets easier to swallow, however the older children found little difference between the tablet sizes. The younger children required more water to swallow each tablet size compared with the older children where an increasing volume of water was consumed as tablet size increased. Taste was rated highly for both age groups. The 8 mm tablets were deemed the most acceptable tablet size by all participants.ConclusionTablets are potentially an acceptable formulation for children aged 4–12 years. Most children aged 4–8 years who attempted to swallow tablets successfully did so. Recruitment of NHS inpatients to medicine acceptability studies is challenging, however, recruitment of children of staff proved an effective strategy. Valuable lessons have been learnt from this feasibility study which will inform the design of a larger definitive trial.
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DuBuske, Lawrence. "Efficacy and safety of sublingual allergen immunotherapy." Allergy and Asthma Proceedings 43, no. 4 (July 1, 2022): 272–80. http://dx.doi.org/10.2500/aap.2022.43.220036.
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Sublingual immunotherapy (SLIT)-tablets represent a new allergen immunotherapy option for clinicians. In North America, there are five SLIT-tablets approved for the treatment of allergic rhinoconjunctivitis (ARC). No SLIT-drops products are currently approved in the United States or Canada. This work reviewed the efficacy of the timothy grass SLIT-tablet, five-grass SLIT-tablet, ragweed SLIT-tablet, house-dust mite SLIT-tablet, and tree SLIT-tablet in patients with ARC. All the SLIT-tablets showed consistent clinical efficacy for the treatment of ARC in large, double-blind, placebo-controlled trials, including for both patients who were monosensitized and those who were polysensitized. Treatment with house-dust mite SLIT-tablet has shown efficacy in patients who are pollen sensitized during their respective pollen seasons. In contrast to SLIT-tablets, efficacy studies of SLIT-drops show high heterogeneity of treatment effect. Although data are scarce, data that compared the efficacy of SLIT-tablets versus ARC pharmacotherapy generally indicated that SLIT-tablets had a greater benefit than pharmacotherapy when compared with placebo, particularly for perennial ARC. When compared with subcutaneous immunotherapy, analysis of these data indicated that SLIT-tablets had a benefit over subcutaneous immunotherapy in regard to safety but somewhat less benefit in regard to efficacy. The safety of SLIT-tablets has been well documented, and a U.S. Food and Drug Administration class label with safety considerations is present in the prescribing information for all SLIT-tablets. No new safety signals have been observed after reinitiating SLIT-tablets after a short treatment interruption.
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Mawson, Charlotte. "7 Development of a leaflet to teach children to swallow tablets." Archives of Disease in Childhood 103, no. 2 (January 19, 2018): e2.47-e2. http://dx.doi.org/10.1136/archdischild-2017-314585.7.
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AimIn paediatric pharmacy a wide range of medications are used, which are often not available in formulations suitable for children. We wanted to design a tool that would enhance our patients’ experience of medication taking as well as improving accessibility to medicines, palatability and ease of administration.MethodThe European Medicines Agency advises that ‘for chronic diseases, the acceptability of tablets in children may be improved by adequate training’.1 Among others a study has shown that almost half of two year olds could swallow a 3 mm tablet, increasing to 85% in 5 year olds.2A leaflet was suggested as the best way to teach our patients and their parents how to swallow tablets as it could be widely distributed. It was developed with a working group of paediatric clinical psychologists and a paediatric pharmacist. The leaflet aims to be encouraging and provide practical tips and advice. It offers seven different techniques for swallowing tablets which were adapted from web-based advice and previous cases. The leaflet was piloted in a small number of patients and they were given a questionnaire.ResultsTen questionnaires were returned, with patients’ ages ranging from 5 to 17. All the patients said that they would now be taking all or some of their medication as tablets. All of the techniques were tried by 2 or more patients and each technique was successful for at least 1 child. The most popular method was the ‘big gulp method’ which worked for 8 patients. This involves swirling the tablet around the mouth for 10 s with as much water as possible and then taking a large gulp until all the water and the tablet have gone.Positive feedback for the leaflet included ‘feels grown up being able to take a tablet’, taking tablets is ‘easier’ and ‘quicker’; one patient wished they had been given the leaflet sooner. Parents also fed back that ‘there was no longer a fight to take medicines’ and ‘it’s much easier for school to manage’.ConclusionThe findings have shown that this is a very successful and useful tool. It allows children and their families to take ownership of their medicine taking. To enable more patients to benefit, further engagement from multidisciplinary teams e.g. play specialists, is needed. In the long-term this leaflet could be used to proactively start patients on tablets rather than reactively, creating potential cost savings and a reduction in the use of unlicensed medicines and specials.ReferencesEuropean Medicines Agency. Guideline on pharmaceutical development of medicines for paediatric use2013. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2013/07/WC500147002.pdf [Accessed: 28 July 2016].Thomson SA, Tuleu C, Wong ICK, et al. Minitablets: New modality to deliver medicines to preschool-aged children. Paediatrics2009;123(2):235–238.
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Rustiani, Erni, Rina Agustina, and Septia Andini. "Formulation and Pharmaceutical Quality Evaluation of Tablets Containing Extract of Cinnamomum burmannii BARK and Colocasia esculenta (L) Schott Leaves." Jurnal Mandala Pharmacon Indonesia 9, no. 1 (June 30, 2023): 27–34. http://dx.doi.org/10.35311/jmpi.v9i1.292.
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Cinnamon bark (Cinnamomum burmannii) is used traditionally and has an ingredient containing cinnamic acid compounds. Colocasia esculenta (L) Schott leaves contains of flavonoids, alkaloids, tannins, saponins, steroids, and terpenoids. Both of the plants C. esculenta and C. burmannii plants have the potential as anti-diabetics because they can lower blood glucose levels. This study aims to make combination tablets of C. burmannii bark and C. esculenta leaves extract with various concentrations of PVP K30 binder. This research made four formulas with the concentration of PVP K30, namely F1 (2%), F2 (3%), F3 (4%), and F4 (5%). Tablet preparations were prepared by the wet granulation method. Tablet analysis used flavonoids quercetin and cinnamic acid as markers. The results showed that the tablets were flat, round in shape, light green, had a slightly bitter taste, and had a distinctive aromatic odor. The differences in the concentration of PVP K30 binder 2-5% could affect the hardness, friability, disintegration time, and tablet dissolution (p<0.05). The tablet's hardness was 3.65-5.01 KP; friability was 0.705%, disintegration time was <15 minutes, and dissolution was 84.61% in 40 minutes. The levels of the flavonoid quercetin in the tablets were 4.21% and 8.03% cinnamic acid. A tablet combination of C. burmannii bark and C. esculenta leaves extract with a PVP K30 concentration of 5% (F4) has the best quality.
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Kumar, Voleti Vijaya, Nandhini M, Sreelekhaa T, Praveen A, E. Saravana Kumar, Srinath M, Vishwa S, and Shanmugapandiyan P. "Comprehensive Review of Oro Dispersible Tablets and Co Processed Super disintegrants." Future Journal of Pharmaceuticals and Health Sciences 4, no. 1 (January 13, 2024): 1–13. http://dx.doi.org/10.26452/fjphs.v4i1.548.
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Due to their ease of administration, self-administration, and improved patient compliance, solid dosage forms are most popular. The most normally utilized strong dose structures are tablets and capsules, which is challenging for pediatric and geriatric patients. Considering these prerequisites endeavors have been made to foster rapid dissolving Tablets. The solid dosage form of a medicine that dissolves in a matter of seconds when swallowed is known as orodispersible tablet. The utilization of Superdisintegrants improves the crumbling season of the tablet. Fast Dissolving Tablets are generally liked because of their convenience, higher bioavailability, quick disintegration and breaking down of the medication. The various technologies utilized in the formulation of Orodispersible tablets (ODT) and their evaluation are the primary focus of this review.
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Sharma, Shaifali, and Anamika Kulshrestha. "Discussion and Ingredients of Different Types of Tablets: A Comprehensive Review." International Journal of Recent Research and Review XV, no. 1 (March 10, 2022): 10–15. http://dx.doi.org/10.62233/ijrrr8.
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Not only is medicine a science, but it is also an art. Instead of mixing pills and plasters, It addresses the basic functions of life that must be understood in order to be guided. Oral solid pharmaceutical dosage forms have been widely used for a long time, primarily due to their ease of use and effectiveness in delivering systemic medications. The tablets can be made from powders straight out of the container, from pellets or granules, or from several film-coated units.Tablets are classified as solid pharmaceutical dosage forms made by moulding or compression that contain medication ingredients with or without appropriate diluents. As a result, two general categories for tablets exist: compressed tablets and moulded tablets. Additional categories for compressed tablets include tablet triturates, chewable tablets, and directly compressible tablets.
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Tranová, Thao, Jolanta Pyteraf, Mateusz Kurek, Witold Jamróz, Witold Brniak, Dita Spálovská, Jan Loskot, et al. "Fused Deposition Modeling as a Possible Approach for the Preparation of Orodispersible Tablets." Pharmaceuticals 15, no. 1 (January 5, 2022): 69. http://dx.doi.org/10.3390/ph15010069.
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Additive manufacturing technologies are considered as a potential way to support individualized pharmacotherapy due to the possibility of the production of small batches of customized tablets characterized by complex structures. We designed five different shapes and analyzed the effect of the surface/mass ratio, the influence of excipients, and storage conditions on the disintegration time of tablets printed using the fused deposition modeling method. As model pharmaceutical active ingredients (APIs), we used paracetamol and domperidone, characterized by different thermal properties, classified into the various Biopharmaceutical Classification System groups. We found that the high surface/mass ratio of the designed tablet shapes together with the addition of mannitol and controlled humidity storage conditions turned out to be crucial for fast tablet’s disintegration. As a result, mean disintegration time was reduced from 5 min 46 s to 2 min 22 s, and from 11 min 43 s to 2 min 25 s for paracetamol- and domperidone-loaded tablets, respectively, fulfilling the European Pharmacopeia requirement for orodispersible tablets (ODTs). The tablet’s immediate release characteristics were confirmed during the dissolution study: over 80% of APIs were released from printlets within 15 min. Thus, this study proved the possibility of using fused deposition modeling for the preparation of ODTs.
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Puspadina, Valiandri, Deny Budi Legowo, Erna Fitriany, Andri Priyoherianto, and Winda Damayanti. "EFFECT OF VARIATION OF LUBRICANT CONCENTRATION (MAGNESIUM STEARATE) ON THE PHYSICAL QUALITY OF METOCLOPRAMID HCl TABLETS WITH DIRECT PRINTING METHOD." Indonesian Journal of Pharmaceutical Education 1, no. 2 (May 27, 2021): 67–75. http://dx.doi.org/10.37311/ijpe.v1i2.10567.
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Metoclopramide HCl is used to relieve nausea and vomiting. Market availability in the form of tablets, syrup and injection. The most preferred drug use by patients is oral medication because of its ease of use. Chewable tablets are a new product as an alternative for treatment in pediatric and adult patients who have difficulty swallowing drugs. This study aims to formulate the chewable tablet preparations of metoclopramide HCl using variations in lubricant concentrations. The variations of magnesium stearate with concentrations of 1%, 2%, and 3% using the direct printing method made to obtain a better physical quality test including organoleptics, weight uniformity, uniformity of size, tablet hardness, tablet brittleness, tablet crush time, uniformity of content. The results of the physical quality test were statistically analyzed using one way ANOVA to determine the effect of variations in the concentration of lubricants on the characteristics of chewable tablets. The results showed that variations in the concentration of magnesium stearate lubricant in the manufacture of metoclopramide HCl chewable tablets had an effect on the physical quality of metoclopramide HCl chewable tablets. The concentration of magnesium stearate which produces metoclopramide HCl chewable tablets with good physical properties is 2%.
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Nurhikmah, Wilda, Erni Rustiani, and Dania Triska Puspita. "PENGEMBANGAN SEDIAAN TABLET ESTROGENIK DARI EKSTRAK RUMPUT KEBAR (Biophytum petersianum) MENGGUNAKAN VARIASI KONSENTRASI PENGIKAT PVP K-30." Jurnal Ilmiah Manuntung 9, no. 2 (December 28, 2023): 111–19. http://dx.doi.org/10.51352/jim.v9i2.661.
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Kebar grass (Biophytum petersianum Klotzsch) contains steroid, saponins, flavonoids, alkaloids, and triterpenoids. The use of Kebar grass extract can increase the development of follicles because it contains saponins which are the basic ingredients for the synthesis of steroid hormones and can improve the performance of reproductive system. This study aims to determine the quality the tablets made from Kebar grass extract with varying concentrations of PVP K-30 binder. Tablets were made in 3 formulas with varying concentrations of PVP K-30 as a binder, namely 2% (F1), 3% (F2), and 4% (F3). Methods of making tablets by wet granulation. Tablet quality testing includes organoleptic, weight uniformity, thickness, diameter, hardness, friability, and disintegration time. The flavonoid quercetin was used as a marker for tablet analysis. The results showed that the tablets were round in shape, white-gray in color, had a slightly bitter taste and had a characteristic aromatic odor. The average value of tablet weight uniformity is 290.06 – 306.45 mg (KV <5%), tablet diameter is 0.91 -0.92 cm, thickness is 0.41 – 0.48 cm, hardness is 4.06 – 7.95 kp, friability 0.17 – 0.21% and tablet disintegration time < 15 minutes. The results of the statistical analysis showed that the differences in the concentration of PVP K-30 did not affect the hardness and friability of the tablets (p> 0.05). The level of the flavonoid quercetin in the tablet is 0.17 – 0.21%. The conclusion that Kebar grass extract tablets can be made using PVP K-30 at a concentration of 2-4% as a binder and the quality of the tablets is not significantly different.
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Horiguchi-Babamoto, Emi, and Makoto Otsuka. "Photochemical stability of warfarin potassium in powdered pharmaceutical tablets." Bio-Medical Materials and Engineering 32, no. 2 (March 23, 2021): 115–29. http://dx.doi.org/10.3233/bme-201167.
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BACKGROUND: Warfarin potassium (Wf) commercial tablets originally formulated for adults are ground before administration to pediatric patients and elderly patients with dysphagia. OBJECTIVE: The present study investigated the effect of tablet grinding on the photostability of four types of commercial Wf tablets and predicted the photostability of the tablet powders by chemometric analysis. METHODS: The photodegradation of Wf content was evaluated by reversed-phase column high-performance liquid chromatography with ultraviolet (HPLC-UV). RESULTS: The bulk Wf powder was relatively photostable, whereas ground Wf tablets underwent substantial photodegradation. The photostability of the ground powders of a brand-name Wf commercial tablet and three generic Wf commercial tablets was quantitatively assessed and compared. In certain cases, the Wf in all the three ground generic tablets was less photostable than in the ground brand-name tablets. After 28 days of light irradiation, the Wf content decreased to 69.79% in the brand-name tablets, while it was 31.90% in some generic tablets. To clarify the factors influencing the relative photostability in various Wf formulations, we analyzed the intermolecular interactions between the active ingredient and the excipients by partial least-squares regression analysis based on photostability screening for each additive. CONCLUSION: The results suggested that the additives light anhydrous silicic acid and povidone adversely affect the stability of Wf tablets. In addition, the light stability of ground tablets was affected considerably by their formulation.
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Alkarib, Suad Y., and Deina E. MohamedElhassan. "Evaluation of Acacia- Guar Gum Combination as Delayed Release Coating Former on Solid Placebo Tablets." Journal of Advanced Pharmaceutical Science And Technology 2, no. 4 (February 12, 2021): 1–10. http://dx.doi.org/10.14302/issn.2328-0182.japst-21-3700.
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Objectives The present study addresses evaluation of acacia-guar gum combination as an enteric former for tablet coating aiming to add knowledge on how develop the ability of enteric forming ability of acacia-guar combination. Methods Five formulations of enteric coating solution incorporating guar gum as delayed release polymers along with film coating material acacia gum followed by CMC and glycerin as plasticizer and coloring agents were prepared to coat placebo tablet cores. Different enteric coating formulations organized in different acacia : guar gum ratios as 1:1, 1:2, 1:3, 1:4 and 1:6 were sprayed on placebo tablets surface resulted different delayed coated tablets (F1,F2,F3,F4 &F5) respectively. General appearance and physical parameters were evaluated of each. Enteric coated tablets that revealed promising properties were subjected to accelerated stability study for 3 months to explore the influences of physical aging on tablet coat properties. Results Physical parameters of enteric coated tablets post coating within the range of pharmacopeia specification. The disintegration test was carried out in pH 1.2 and pH 6.8 at 37ºC. F1, F2 and F3 enteric tablets disintegrated immediately with no acid resistance compared F4 and F5 enteric tablets showed good acid resistance coat with smooth tablet surfaces and no coat defects. F5 formula contain acacia: guar gum as 1:6 ratio showed delayed release for 30min in pH 1.2 and 15min in phosphate buffer. The study statistically analyzed and concluded that, an efficient and stable acacia-guar enteric coat is achievable with no effect on tablets physical parameters. Guar gum at 60% as a delayed tablet coating material capable of protecting the tablets core from being released in acidic media and be release in the alkaline buffer as well as stable coat under accelerated storage for three months.
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Peters, I. O. M., A. Willemsen, J. J. de Bruyne, and R. C. Nap. "Aspirin Medication in Dogs." Veterinary and Comparative Orthopaedics and Traumatology 4, no. 03 (1991): 95–99. http://dx.doi.org/10.1055/s-0038-1633260.
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SummaryAspirin (acetylsalicylic acid; ASA) is widely used in both human and veterinary medicine. Therapeutic plasma salicylate concentrations (PSCs) can be reached using enteric-coated ASA tablets, but a delay in the initial rise and large fluctuations in the PSCs have been reported. From experiments described previously, the authors concluded that the large type enteric-coated ASA tablets were not suitable for use in beagle dogs.In the first experiment described here, these large type tablets were administered to large mongrel dogs. Although the mean PSC reached therapeutic levels after 44 h, in individual dogs subtherapeutic concentrations were frequently recorded. In the second experiment microgranulated type enteric-coated ASA tablets were given to beagle dogs in a crossover design study. PSCs in all dogs exceeded minimal therapeutic levels 6 h after tablet administration. Stable therapeutic PSCs were found in both groups on different feeding regimens. In the third experiment the two types of enteric-coated ASA tablets were administered to fasting beagles. Comparable therapeutic PSCs were reached with both formulations.From the present studies it can be concluded that the large type enteric-coated ASA tablet is not suitable for use in large mongrel dogs. Secondly, it can be concluded that the microgranulated type enteric-coated ASA tablet is suitable for the use in beagle dogs. In the third experiment it was proven that fasting eliminated the differences in mean PSC curves between the two types of ASA medication.On the basis of canine gastric physiology the authors expect similar types of large enteric-coated tablets of other drugs to generate comparably poor plasma concentrations. The gastric evacuation of tablets is primarily related to the tablet dimensions and digestibility, and not to the drug contained by these tablets.
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Isaac, Johnson Ajeh, and Kayode Ilesanmi Fasuba. "Finding Use for Sorghum Bicolor Leaf Sheath in Coating Technology." Pharmaceutical Fronts 03, no. 03 (September 2021): e119-e128. http://dx.doi.org/10.1055/s-0041-1736235.
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This study aimed to investigate the potential use of aqueous extract of Sorghum bicolor leaf sheath (SBLS) as a coating agent for paracetamol tablets. The mechanical properties of the coated tablets were assessed using crushing strength and friability test, while the release properties of the tablet were evaluated using disintegration and dissolution tests. The physicochemical properties of the coated tablets did not show any striking differences when compared with the uncoated tablet as par compendium specifications, which formed the basis for performing further in vitro dissolution study. Our data showed that SBLS enhanced the hardness and friability of the tablets in a dose-dependent manner. Tablets coated with 3, 5, and 7.5% of SBLS disintegrated in 8.13, 6.25, and 4.13 minutes, respectively, while the uncoated tablet disintegrated in 0.7 minutes. Furthermore, 3, 5, and 7.5% of SBLS-coated tablets exhibited slower release of their active ingredient (releasing 21, 16, and 17%, respectively) than that of the uncoated tablet (releasing 40%) in 5 minutes. Besides, comparison between the dissolution profiles was successfully achieved using difference factor (f1) and similarity factor (f2). The apparent dissimilarity between our coated tablets and the uncoated one led to further study of convolution in vitro–in vivo correlation, with the aim to obtain data that converted into mathematical prediction of in vivo data. For all batches, the percent predictable errors of C max and T max were within the acceptable limit of no more than 10%. In summary, SBLS aqueous extract is a potential and protective coat agent for paracetamol tablets. The in vitro established dissolution of the coated tablets provided scientific information for the prediction of the in vivo plasma drug profile.
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Zhao, Feng, Meng Li, Lingling Meng, Jinhan Yu, and Tiehua Zhang. "Characteristics of Effervescent Tablets of Lactobacilli Supplemented with Chinese Ginseng (Panax ginseng C.A. Meyer) and Polygonatum sibiricum." Applied Sciences 10, no. 9 (May 3, 2020): 3194. http://dx.doi.org/10.3390/app10093194.
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Development of probiotic products has always been popular in the food industry. Considering the advantages of effervescent tablets, developing probiotic products in effervescent tablet form was conducted in this study. Besides three Lactobacillus species, whole root powders of two medicine food homology herbs, Chinese ginseng (Panax ginseng C.A. Meyer) and Polygonatum sibiricum, were added to the formulation in equal amounts for multiple health care functions. Using the plate counting method, the viability of lactobacilli was measured. After tabletting, lactobacilli viability in tablets containing the two herbs, L-group (20 mg herbs/tablet), M-group (60 mg herbs/tablet), and H-group (100 mg herbs/tablet) was higher than that in the control (containing no herbs). After tablet disintegration, the survival rate of lactobacilli after gastrointestinal fluids treatment was measured; it was higher for the L-group and the H-group than for the control. After incubation with dissolved tablets for 1 h, the lethal rate of Staphylococcus aureus and Escherichia coli O157:H7 for tablets containing the herbs was lower than that for the control. In the organoleptic assessment test, the L-group and the control were preferred to the M-group and the H-group. During storage at 25 °C for two months, the viability of lactobacilli in tablets containing the herbs was similar to that in the control. In conclusion, the formulation of the L-group has the best characteristics.
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NIZAMI, FARIDA, and YOGENDRA MALVIYA. "RECENT ADVANCEMENT AND CHALLENGES IN BILAYER TABLET TECHNOLOGY: AN OVERVIEW." Current Research in Pharmaceutical Sciences 11, no. 4 (January 8, 2022): 91–97. http://dx.doi.org/10.24092/crps.2021.110401.
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Bilayer tablets were developed recently for the effective production of controlled release formulations in various quality levels to give a method of successful drug delivery. Over the last three decades, as the cost and complexity of developing novel pharmacological entities have increased and as the therapeutic benefits of controlled drug administration have been recognized, considerable attention has been focused on developing sustained or controlled release drug delivery systems. It is utilized to produce a variety of antihypertensive formulations. Bilayer tablets allow for the predetermined release of two drugs in combination, separating two incompatible substances, and sustained-release tablets with one layer serving as the loading dose and the second layer serving as the maintenance dose. Bilayer tablets are advancing helpful technologies to overcome the disadvantages of single-layered tablets. However, bilayer tablet technology is resource-intensive. A thorough selection of excipients and manufacturing conditions for each technical stage is also required. The purpose of this paper is to summarize the state of art in bilayer tablet technology and to highlight the difficulties encountered during bilayer tablet manufacture, as well as the possible solutions for these obstacles. KEYWORDS: Bilayer tablet, Conventional release, Controlled release, Sustained release, Maintenance dose
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Meitia Sandy, Deby, and Suci Sulistyorini. "PENGETAHUAN MENINGKATKAN KEPATUHAN MENGKONSUMSI TABLET FE PADA IBU HAMIL." Jurnal Ilmiah Pamenang 5, no. 2 (December 20, 2023): 67–71. http://dx.doi.org/10.53599/jip.v5i2.191.
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Abstrak Tablet Fe (zat besi) merupakan zat yang sangat essensial bagi tubuh. Pada ibu hamil konsumsi zat besi digunakan sebagai salah satu upaya penanggulangan kekurangan zat besi. Upaya ini direkomendasikan secara universal di negara-negara berkembang. Program pemerintah mengharuskan setiap ibu hamil untuk mengkonsumsi tablet zat besi selama masa kehamilan minimal 90 tablet untuk mencegah terjadinya anemia dalam kehamilan. Tujuan penelitian ini untuk mengetahui hubungan pengetahuan dengan kepatuhan dalam mengkonsumsi tablet Fe pada ibu hamil. Metode penelitian ini analitik korelatif dengan pendekatan cross sectional. Penelitian ini dilakukan di PMB Choirul Mala Palembang dengan jumlah sampel sebanyak 38 responden. Teknik pengambilan sampel dengan tekhnik total sampling. Variabel independen yaitu pengetahuan dan variabel dependen yaitu kepatuhan mengkonsumsi tablet Fe pada ibu hamil. Data dianalisa dengan menggunakan uji korelasi pearson. Hasil penelitian menunjukkan bahwa diperoleh 63,2% ibu hamil berpengetahuan baik dan 60,5% ibu patuh dalam mengkonsumsi tablet Fe. Didapatkan nilai p- value 0,038 artinya ada hubungan antara pengetahuan dengan kepatuhan dalam mengkonsumsi Tablet Fe pada ibu hamil. Untuk para ibu hamil harus sering dilakukan penyuluhan oleh tenaga kesehatan tentang manfaat konsumsi tablet Fe bagi ibu dan janin sehingga membuat ibu menjadi patuh untuk mengkonsumsi tablet Fe. Kata kunci : Pengetahuan, Kepatuhan, Tablet Fe Abstract Fe tablets (iron) are very essential substances for the body. In pregnant women, iron consumption is used as an effort to overcome iron deficiency. This effort is universally recommended in developing countries. The government program requires every pregnant woman to take iron tablets during pregnancy at least 90 tablets to prevent anemia in pregnancy. The purpose of this study was to determine the relationship of knowledge with adherence in consuming Fe tablets in pregnant women. This research method is analytically correlative with a cross sectional approach. This research was conducted at PMB Choirul Mala Palembang with a sample of 38 respondents. Sampling technique with total sampling technique. The independent variable is knowledge and the dependent variable is adherence to consuming Fe tablets in pregnant women. The data were analyzed using the person correlation test. The results showed that 63.2% of pregnant women were well-informed and 60.5% of mothers were obedient in consuming Fe tablets. A p-value of 0.038 means that there is a relationship between knowledge and adherence in consuming Fe tablets in pregnant women. For pregnant women, counseling must often be done by health workers about the benefits of Fe tablet consumption for fetal mothers so as to make mothers obedient to consume Fe tablets. Keywords : Knowledge, adherence, fe tablet
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Patimah, Patimah, Junie Suriawati, and Siti Rahayu Rahmawati. "Development Of Caulis Extract (Tinospora Crispa (L.) Hook. F. & Thomson As Plasmodium In Preparations Tablets." SANITAS : Jurnal Teknologi dan Seni Kesehatan 9, no. 1 (June 1, 2018): 6–15. http://dx.doi.org/10.36525/sanitas.2018.2.
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Brotowali (Tinospora crispa (L.) Hook. f. Thomson is a wild plant & in the Woods, fields or planted page near the fence, and the usual planted as medicinal plants. The entire plant (roots, stems, and leaves) has a bitter taste that can be used as a traditional medicine as Plasmodium. This research aims to make the tablet dosage of Caulis extract with gelatin Binder and polivenilpirolidon materials that meet the requirements of the physical quality of a tablet that is acceptable. Prior to the manufacture of tablets do extract raw materials testing which includes the determination of the levels of ash, determination of microbial impurities, testing the determination of aflatoxin levels of impurities, the determination of the levels of pesticide residues, the determination of the level of heavy metal impurities. Caulis extract tablet manufacture is made with two formula with each different binding materials, namely formula I used gelatin formula II 5% and 5% use polivinilpirolidon. The methods used in the manufacture of Caulis extract tablets using a wet granulation method. Granul tested his physical properties obtained covering moist, flow properties, compressibility granule. Tablets obtained physical quality test performed which include uniformity of weight, hardness, size uniformity, compressibility, and the crushed tablets. The data obtained were analyzed statistically using SPSS 15.0 for windows program namely testing T-Test with a 5% confidence. The results showed that the two formula tablets with the uniformity of weight, hardness, size uniformity, compressibility, and the time crushed tablet that meets the requirements of the physical quality of a good tablet. The conclusions of this research are extracted Caulis tablet can be created that meets the requirements of physical quality test tablet.
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Coutinho, Ana Luisa, Asmita Adhikari, and James Polli. "10122 Development of an In Vitro in Vivo Correlation of Itraconazole Spray-Dried Dispersion Tablets." Journal of Clinical and Translational Science 5, s1 (March 2021): 96–97. http://dx.doi.org/10.1017/cts.2021.649.
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ABSTRACT IMPACT: As the number of poorly water-soluble drugs in development increases, our research will expand on the science behind improving drug solubility and absorption and ensuring that promising poorly-water solubility drugs do not fail drug development. OBJECTIVES/GOALS: Spray-dried dispersion (SDD) tablet formulation is an approach to increase oral drug solubility and absorption. Methods to predict SDD performance in humans are poorly developed. We aim to develop an in vivo in vitro correlation (IVIVC) between in vitro dissolution and in vivo absorption of itraconazole SDD tablets. METHODS/STUDY POPULATION: This research project involves tablet manufacturing, in vitro dissolution experiments, and a clinical study. We manufactured fast-, medium-, and slow-release SDD tablets containing amorphous solid dispersion of itraconazole (100 mg) and different grades of the polymer hypromellose acetate succinate (HPMC-AS). Tablets differed in slug pressure, tablet compression force, and formulation composition. Dissolution studies were performed using the United States Pharmacopeia (USP) type II apparatus. The clinical study is an ongoing randomized, cross-over, open-label, fasted, single-dose trial in healthy participants (n=12). An IVIVC will be created by comparing the rank order of drug in vitro dissolution with in vivo absorption. RESULTS/ANTICIPATED RESULTS: Tablet manufacturing was successful, and the tablets displayed the same dissolution rate ranking order as anticipated. Fast-release tablets showed the highest percentage of drug dissolved by 10 min (74%) compared to medium- (62%) and slow-release (1.2%) tablets. Percentage drug dissolved differs by at least 10% at all time points among the different release-rate tablets. The clinical study is currently ongoing, and we expect that the pharmacokinetic (PK) profiles differ among the different tablets. We predict that the rank order of tablet absorption in humans will agree with the order of drug dissolved observed in the dissolution experiments. DISCUSSION/SIGNIFICANCE OF FINDINGS: Spray-dried dispersions are a formulation method to try to improve drug solubility and oral drug absorption. This research will elucidate manufacturing parameters that can impact tablet performance and expand on the ability of in vitro dissolution to predict human PK and streamline drug development of poorly soluble drug candidates.
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Ahmed, Tarek A., Raed I. Felimban, Hossam H. Tayeb, Waleed Y. Rizg, Fuad H. Alnadwi, Hanadi A. Alotaibi, Nabil A. Alhakamy, et al. "Development of Multi-Compartment 3D-Printed Tablets Loaded with Self-Nanoemulsified Formulations of Various Drugs: A New Strategy for Personalized Medicine." Pharmaceutics 13, no. 10 (October 19, 2021): 1733. http://dx.doi.org/10.3390/pharmaceutics13101733.
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This work aimed to develop a three-dimensional printed (3DP) tablet containing glimepiride (GLMP) and/or rosuvastatin (RSV) for treatment of dyslipidemia in patients with diabetes. Curcumin oil was extracted from the dried rhizomes of Curcuma longa and utilized to develop a self-nanoemulsifying drug delivery system (SNEDDS). Screening mixture experimental design was conducted to develop SNEDDS formulation with a minimum droplet size. Five different semi-solid pastes were prepared and rheologically characterized. The prepared pastes were used to develop 3DP tablets using extrusion printing. The quality attributes of the 3DP tablets were evaluated. A non-compartmental extravascular pharmacokinetic model was implemented to investigate the in vivo behavior of the prepared tablets and the studied marketed products. The optimized SNEDDS, of a 94.43 ± 3.55 nm droplet size, was found to contain 15%, 75%, and 10% of oil, polyethylene glycol 400, and tween 80, respectively. The prepared pastes revealed a shear-thinning of pseudoplastic flow behavior. Flat-faced round tablets of 15 mm diameter and 5.6–11.2 mm thickness were successfully printed and illustrated good criteria for friability, weight variation, and content uniformity. Drug release was superior from SNEDDS-based tablets when compared to non-SNEDDS tablets. Scanning electron microscopy study of the 3DP tablets revealed a semi-porous surface that exhibited some curvature with the appearance of tortuosity and a gel porous-like structure of the inner section. GLMP and RSV demonstrated relative bioavailability of 159.50% and 245.16%, respectively. Accordingly, the developed 3DP tablets could be considered as a promising combined oral drug therapy used in treatment of metabolic disorders. However, clinical studies are needed to investigate their efficacy and safety.
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Ittadwar, Parul A., and Prashant k. Puranik. "Formulation and Evaluation of Gastro-retentive Drug Delivery System of Novel Famotidine Phospholipid Complex." International Journal of Pharmaceutical Sciences and Drug Research 15, no. 03 (June 30, 2023): 250–59. http://dx.doi.org/10.25004/ijpsdr.2023.150304.
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Famotidine is an H2 receptor antagonist belonging to the BCS Class II, characterized by low solubility and limited oral bioavailability. The current study encompasses the formulation of novel famotidine phospholipid complex (FHC) with the aid of design of experiments (Central Composite Design) using solvent evaporation technique to overcome the disadvantages of Famotidine. To further enhance the physicochemical properties of FHC, it was incorporated into gastro-retentive floating tablets (GRDDS) using direct compression technique with sodium bicarbonate as a gas generating agent and its properties were compared to famotidine floating tablets. The pre-compression parameters, namely bulk density, tapped density, Hausner’s ratio, Carr’s compressibility index and angle of repose were evaluated. The flow properties of FHC granules were found to be better than the plain famotidine granules. The postcompression parameters, namely thickness, hardness, friability, weight variation, drug content and swelling index showed better results for FHC as compared to famotidine floating tablets. In-vitro buoyancy study indicated that the floating lag time for FHC tablets (110 ± 0.021 seconds) was higher than famotidine tablets (36 ± 0.033 seconds) owing to the higher molecular weight of phosphatidylcholine. But the total floating time for FHC tablets was found to be more than 18 hours and for famotidine tablets it was ~12 hours, indicating the improved residence time and buoyancy. The in-vitro dissolution study depicted that the cumulative release for FHC tablets (99.84 ± 0.058%) was enhanced 1.07 fold than Famotidine tablets (92.73 ± 0.028%) and 1.6 fold than marketed tablet, Famocid (62.24 ± 0.023%). When kinetic modeling was performed, famotidine tablet followed zero order kinetics, whereas FHC tablet followed Higuchi model indicating a modified and sustained release pattern. The statistical analysis for %cumulative release performed using ANOVA and Dunnett’s test showed the p-value to be below 0.05 (0.0043) indicating that the analysis model was significant. An accelerated stability study was performed for a period of 6 months at 25 ± 2°C; 60 ± 5% RH. FHC tablets showed a better stability profile than famotidine tablets. In conclusion, FHC gastro-retentive floating tablets showed improved flow properties, post compression properties, better drug content, improved in-vitro buoyancy and enhanced cumulative release and stability profile.
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Cao, Ying, Guowang Yao, Yuanyuan Sheng, Li Yang, Zixuan Wang, Zhen Yang, Pengwei Zhuang, and Yanjun Zhang. "JinQi Jiangtang Tablet Regulates Gut Microbiota and Improve Insulin Sensitivity in Type 2 Diabetes Mice." Journal of Diabetes Research 2019 (January 10, 2019): 1–12. http://dx.doi.org/10.1155/2019/1872134.
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Background. Gut microbiota modulates the barrier function and host inflammatory state in metabolic disease. JinQi Jiangtang (JQJT) tablets are a traditional Chinese medicine for the treatment of diabetes. However, the low bioavailability of its chemical compositions makes it hard to explain the pharmacological mechanisms.Method. Diabetic mice were orally treated with JQJT tablets for 5 weeks. Fasting blood glucose and the level of HbA1c were measured, and ITT were conducted to determine the insulin improvement effect of JQJT tablets. The regulation effect on gut microbiota was assessed by 16S rRNA gene sequencing on an Illumina HiSeq platform. The concentration of short-chain fatty acids was measured by HS-GC/MS. D-LA leakage experiment and PAS staining were used to check the function of the gut barrier. The levels of the inflammatory cytokines were determined by using an ELISA kit.Results. This study showed that JQJT tablets downregulated fasting blood glucose and HbA1c and regulated gut microbiota. JQJT tablet-treated groups exhibited a more sensitive reaction after a small-dose injection of short-acting insulin. T2DM mice treated with JQJT tablets showed a higher abundance ofAkkermansiaspp. and lower abundance ofDesulfovibrio. JQJT tablets increased the concentration of acetic acid, propionic acid, and butyric acid; in particular, butyric acid was significantly increased with respect to the MOD group. Gut mucosal barrier function experiment showed that the level of D-LA was obviously decreased in JQJT tablet-treated groups compared with the model group and the number of goblet cells was significantly increased by JQJT tablet treatment. JQJT tablets could also reduce the levels of TNF-α, IL-6, and MCP-1, which were related to insulin resistance.Conclusion. We demonstrated that JQJT tablets could improve T2DM insulin resistance, regulating the gut microbiota and promoting the production of SCFAs. The mechanism was related to increasing the gut barrier function and reducing the host inflammatory reaction.
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Kailash Sahu, Vimlendu Kumar, Pooja Lodhi, and Bhaskar Kumar Gupta. "Different types of pharmaceutical tablets used for treatment of diseases." GSC Biological and Pharmaceutical Sciences 21, no. 2 (November 30, 2022): 001–11. http://dx.doi.org/10.30574/gscbps.2022.21.2.0398.
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In modern age of revolution and development in drug delivery for better clinical effects conventional dosages form have still a strong grip and most popular in all kinds of medicinal preparation intended for oral use. To satisfy the need of growing market tablets dosages form have incorporated modernization in producing and some advanced tablet types. Modified release tablet formulations including, layered tablets such as In +--lay tablet, Bi-layered tablet, Medicated chewing gum, Tablet tarts, Pastilles, Lollipop, Tablet inserts, Clinicaps, Caplets, Child ecstasy tablet and Tablet in tablet are new entries in pharmaceutical market. This review highlights the current advancements and patents in tablet technology. Recent advances in novel drug delivery system (NDDS) aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for ease of administration and to achieve better patient compliance. In the recent trend one such approach the development of rapid disintegrating tablets formulation is emerging and gaining popularity because it is easy to administer and leads to better patient compliance. These dosage forms are placed in the mouth, allowed to disperse or dissolve in the saliva. They release the drug as soon as they come in contact with the saliva, thus obviating the need for water during administration. The aim of this article is to review the progress of the evolving technologies and super disintegrating agents in the formulation, manufacturing and evaluation of these tablets. This article also discusses the new evaluation methodologies for these rapid disintegrating tablets. Various modifications in the conventional evaluation and use of specialized instruments are found to be essential in the testing of these dosage forms. In the present review the formulation techniques and different technologies are discussed.
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Mayunita, Abela, and Rezky Avriliatin. "Efektivitas Pemberian Tablet Fe + Jeruk Manis Dengan Tablet Fe + Pisang Ambon Terhadap Kadar Hb Ibu Hamil Anemia di Klinik Edelweis Medical Centre Kota Tangerang." Malahayati Nursing Journal 6, no. 2 (February 1, 2024): 429–44. http://dx.doi.org/10.33024/mnj.v6i2.10707.
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Anemia is a nutritional disorder that is often found and is a major nutritional problem in Indonesia. The Edelweis Medical Center Clinic in Tangerang City in 2021 there will be 26.8% of pregnant women who will experience anemia. In order to meet iron needs, the government through its program provides iron (Fe) tablets at least 90 tablets. One effort to increase Hb levels in anemic pregnant women is by increasing the absorption of iron from foods, such as sweet oranges and Ambon bananas. Knowing the effectiveness of giving Fe tablets + sweet orange with Fe tablets + Ambon banana on Hb levels of anemic pregnant women at the Edelweis Medical Center Clinic in Tangerang City in 2023. Quasy experimental design with pretest-posttest design with control group design. The sample is pregnant women who experience anemia in January-February 2023 at the Edelweis Medical Center Clinic in Tangerang City as many as 34 samples using a purposive sampling technique. The intervention was given 250g once a day for 7 days. Bivariate analysis used paired simple t test and independent t test. The results of the univariate study of Hb levels of pregnant women before administration of Fe tablets + sweet orange averaged = 9.629 gr/dl and after administration of Fe tablets + sweet orange averaged = 11.441gr/dl. Hb levels of pregnant women before administration of Fe tablets + Ambon bananas averaged = 9.635 gr/dl and after administration of Fe tablets + Ambon bananas averaged = 12.118 gr/dl. The bivariate results of the paired simple t test were 0.000 and the independent t test obtained a p value = 0.000.There are differences in Hb levels of anemic pregnant women between Fe tablets + sweet orange and Fe tablets + Ambon bananas. Pregnant women are expected to be diligent in consuming foods that contain iron, one of which is Ambon bananas and sweet oranges so that they can increase Hb levels in the mother's blood, while the process of eating them besides making juice can also be eaten directly. Keywords: Fe Tablets, Ambon Bananas, Sweet Oranges, Hb Levels in Anemia Pregnant Women ABSTRAK Anemia merupakan salah satu penyakit gangguan gizi yang masih sering ditemukan dan merupakan masalah gizi utama di Indonesia. Klinik Edelweis Medical Centre Kota Tangerang pada tahun 2021 ibu hamil yang mengalami anemia sebanyak 26,8%. Agar dapat memenuhi kebutuhan zat besi, pemerintah melalui programnya memberikan tablet besi (Fe) minimal 90 tablet. Salah satu upaya untuk meningkatkan kadar Hb ibu hamil anemia dengan meningkatkan penyerapan zat besi dari makanan, seperti jeruk manis dan pisang ambon. Mengetahui efektivitas pemberian tablet Fe + jeruk manis dengan tablet Fe + pisang ambon terhadap kadar Hb ibu hamil anemia di Klinik Edelweis Medical Centre Kota Tangerang tahun 2023. Quasy eksperimental desain dengan rancangan pretest-posttest with control group design. Sampel adalah ibu hamil yang mengalami anemia pada bulan Januari-Februari tahun 2023 di Klinik Edelweis Medical Centre Kota Tangerang sebanyak 34 sampel dengan teknik purposive sampling. Intervensi diberikan 1 x sehari 250g selama 7 hari. Analisis bivariat menggunakan uji paired simple t test dan t test independent. Hasil penelitian univariat kadar Hb ibu hamil sebelum pemberian tablet Fe + jeruk manis rata-rata = 9,629 gr/dl dan sesudah pemberian tablet Fe + jeruk manis rata-rata = 11,441gr/dl. Kadar Hb ibu hamil sebelum pemberian tablet Fe + pisang ambon rata-rata = 9,635 gr/dl dan sesudah pemberian tablet Fe + pisang ambon rata-rata = 12,118 gr/dl. Hasil penelitian bivariat uji paired simple t test sebesar 0,000 dan uji t test independent didapatkan nilai p value = 0,000. Terdapat perbedaan kadar Hb ibu hamil anemia antara pemberian tablet Fe + jeruk manis dengan tablet Fe + pisang ambon. Ibu hamil diharapkan rajin mengkonsumsi makanan yang mengandung zat besi salah satunya buah pisang ambon dan jeruk manis agar dapat meningkatkan kadar Hb dalam darah ibu, adapun proses memakannya selain dibuat jus juga boleh dimakan langsung. Kata Kunci: Tablet Fe, Pisang Ambon, Jeruk Manis, Kadar Hb Ibu Hamil Anemia
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Terenteva, O. A., E. V. Flisyuk, D. Yu Ivkin, and I. A. Narkevich. "Development of the Composition and Technology of New Neuroprotective Drug Tablets Using Fractional Factorial Design." Drug development & registration 9, no. 1 (February 26, 2020): 18–22. http://dx.doi.org/10.33380/2305-2066-2020-9-1-18-22.
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Introduction. The creating an effective and safe domestic neuroprotective medicines with a complex of pleiotropic effects realized through specific orphan receptors (SUCNR1, HCA2) of glial cells, is a pressing problem of modern pharmacology and a promising possibility of pharmacotherapy of brain injury and cerebrovascular diseases. Ideally, the medicine should helps restore lost cognitive functions and physical performance after damage to the central nervous system, and its use should improve the quality of life of patients and reduce the risk of complications.Aim. To develop composition and technology of a new medicine tablets with neuroprotective effect, using fractional factorial design of experiment and the Harrington desirability function.Materials and methods. The shape and size of particles, physicochemical (solubility, melting point) and technological properties (bulk density, compressibility factor, fractional composition, hygroscopicity) of the pharmaceutical substance of DEAE derivative were studied according to the methods described in the State Pharmacopoeia of the Russian Federation (14th edition). A three-factor fractional plan based on the 4 × 4 Latin square design for selection a scientifically based composition of solid dosage form was chosen. 16 experiments to test the significance of the factors were carried out. The tablets obtained according to the planning matrix were investigated for disintegration; tablet crush resistance, friability, and hygroscopicity. To optimize the quality of the tablets, the generalized Harrington desirability function was used.Results and discussion. The study of the physicochemical and technological properties of the DEAE derivative substance showed that it is a highly hygroscopic, amorphous, white or pale yellow, odourless powder, prone to the formation of agglomerates. The powder is very easily soluble in water. Taking into account the values of the general desirability function, the best result was shown by sample № 4 consisting of mannitol, calcium stearate, and partially pregelatinized maize starch.Conclusion. The physicochemical and technological properties of the DEAE derivative were studied. The DEAE derivative is a highly hygroscopic substance. Via the method of mathematical planning of the experiment the composition of DEAE derivative tablets was selected and scientifically grounded: DEAE derivative 60 mg, mannitol, partially pregelatinized maize starch, calcium stearate. The average tablet weight is 300 mg. The parameters of pressing tablets were selected.
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Nur Cahyani, Arinda, Adi Susanto, Iva Rinia Dewi, and Iswatun Nurhikmah. "FORMULASI TABLET PARASETAMOL DENGAN KOMBINASI PVP DAN AMILUM UMBI PORANG (Amorphopallus onchopyllus) SEBAGAI BAHAN PENGIKAT TERHADAP SIFAT FISIK TABLET." Jurnal Ilmiah JOPHUS : Journal Of Pharmacy UMUS 4, no. 02 (February 28, 2023): 1–11. http://dx.doi.org/10.46772/jophus.v4i02.886.
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Tablets are the most widely used preparations, this is because tablets have advantages that other pharmaceutical preparations do not have, both in terms of production, storage, distribution, and use. This study aims to determine the concentration of PVP and starch from porang tubers which can be used as a binder in the preparation of paracetamol tablets and to determine the combination of PVP and starch from porang tubers as a binder to the physical properties of paracetamol tablets. In this study, 4 paracetamol tablet formulas with PVP binder were made combined with porang tuber starch with a weight of 650 mg per tablet. The binder used was PVP in each formula, namely F1 0%, F2 1%, F3 3%, and F4 5%, and porang tuber starch in each formula was F1 5%, F2 0%, F3 6%, and F4 7%. Tablets were made using wet granulation, the granules obtained were tested for their physical properties. including moisture content, flow time, angle of repose, and compressibility. After the powder mixture was compressed with a hardness between 4-8 kg, the resulting tablets were then tested for their physical properties including weight uniformity, size uniformity, friability, hardness, and disintegration time. The tablets produced from all formulas met the uniformity of weight, uniformity of size, and friability, the hardness that met the physical properties of the tablets was only found in formula I, which was 7.30 kg, and the fastest disintegration time in formula I was 9.6 minutes.
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Dhakal, Neelam, Pradip Gyanwali, Baburam Humagain, Rajendra BC, Nisha Jha, Phoolgen Sah, Amita Pradhan, Meghnath Dhimal, and Anjani Kumar Jha. "Assessment of quality of essential medicines in public health care facilities of Nepal: Findings of nationwide study." PLOS Global Public Health 3, no. 5 (May 25, 2023): e0001841. http://dx.doi.org/10.1371/journal.pgph.0001841.
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Essential medicines are those medicines that satisfy the primary health care needs of the citizens. Poor quality of essential medicines can have serious impact on public health. Thus, this study is aimed to assess the quality of essential medicines available in public health care facilities of Nepal. A cross sectional descriptive study was carried out in 62 health facilities across 21 districts, representing all seven provinces of Nepal and selected proportionately from all three ecological regions i.e. Terai, Hill and Mountain using lottery method. Health facilities in selected districts were chosen using random number generator. Face to face interview was taken with health facility in charge using structured questionnaire. All storage conditions information was recorded through observation checklists. Temperature and humidity were measured using a digital instrument. Similarly, 20 different generic medicines were collected for quality testing. The obtained data were entered in Epidata version 3.1, cleaned in Microsoft Excel 2007 and analyzed in SPSS version 16.0. Among 62 health facilities, only 13% of health facilities were found to follow the medicine storage guidelines, with temperature and humidity levels exceeding recommended limits. Out of 244 batches of 20 different generics of essential medicines, 37 batches were found to be substandard. These substandard medicines were- Ciprofloxacin hydrochloride eye/ear drop, Iron supplement tablets, Metformin Hydrochloric tablet, Metronidazole Tablets, Paracetamol Oral suspension, Paracetamol tablet and Povidone Iodine solution. The study recommends the urgent need for the Government of Nepal to prioritize ensuring the quality of essential medicines in the country.
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Sinaga, Alex, and Adelya I. Manalu. "PENGARUH VARIASI KONSENTRASI AMILUM JANTUNG PISANG BATU SEBAGAI BAHAN PENGIKAT TERHADAP SIFAT FISIK TABLET ASAM ASETIL SALISILAT." JIFI (Jurnal Ilmiah Farmasi Imelda) 4, no. 2 (March 31, 2021): 28–36. http://dx.doi.org/10.52943/jifarmasi.v4i2.518.
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Tablet dosage form is one of the most widely used pharmaceutical. Acetyl salicylic acid is an anti inflammatory medicine, active substance not heat resistant. Starch as a binder of materials in the manufacture of tablets are hydrophilic because amylopectin starch can absorb most of the water. This study aims to determine the variation of the concentration of starch banana heart of stone as the material of binder on physico-chemical properties acid tablets acetyl salicylic meet the requirements of the Indonesian Pharmacopoeia. Based on the explanation above, the research conducted to make four concentration of the starch of banana, i.e. FI (5%), FII (10%), FIII (12.5%) and FIV (15%). From the results evaluation obtained include : flow time, steep angle, indication index, uniformity of weight, hardness, fragility and crumbling time of tablets, all formulas have been qualified by Pharmacopoeia Indonesia. Formulation IV after investigation had better tablet quality.
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Penabaka VenugopalaiahPenabaka Venugopalaiah, KP Benidicts Prem Prakash, Yerikala Ramesh, and M Alagusundaram. "Formulation and evaluation of extended-release tablets of trimetazidine HCL." World Journal of Advanced Research and Reviews 18, no. 3 (June 30, 2023): 993–1002. http://dx.doi.org/10.30574/wjarr.2023.18.3.1003.
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The present study was undertaken with an aim to formulate develop and evaluate Trimetazidine HCL extended release matrix tablets using different polymers as release retarding agent. Pre formulation study was done initially and results directed for the further course of formulation. Based on Pre formulation studies different batches of Trimetazidine HCL were prepared using selected excipients. Powders were evaluated for tests Angle of repose, Bulk density, tapped density, compressibility index, and Hausner ratio before being punched as tablets. It was concluded that the tablets of batch F9 had considerable swelling behaviors and in vitro drug release. Percentage drug release in 8 hr is 80.77. It was observed that tablets of batch F9 followed the Huguchi release profiles. From the results and discussion it is concluded that formulation of Extended release matrix tablet of HCL containing HPMC K-15 (19.44%) and Hyper mellose (19.44%), Ethyl cellulose (19.44%) batch F9 can be taken as an ideal or optimized formulation Extended release matrix tablet for 8 hour release as it fulfills the requirements for extended release matrix tablet.
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Sakai, Tatsuo, Akio Kokubu, Shoichi Kikuchi, Hiroshi Tanaka, Fumiharu Ikai, and Kazutaka Okumoto. "A Study on Very High Cycle Fatigue Property of High Strength Steel for Particular Use as Medical Tablets Compressing Punches." Key Engineering Materials 664 (September 2015): 221–30. http://dx.doi.org/10.4028/www.scientific.net/kem.664.221.
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In the fabrication process of medicine tablets, working speed of the tablet compressing is an important factor to realize the high fabricating efficiency together with the low cost. Thus, a number of loadings would be applied with very high frequency to tips of a couple of compressing punches. Sometimes, the tablet compressing speed exceeds 150 tablets per second. Due to such a circumstance, the very high cycle loadings are applied to the tips of the compressing punches making medicine tablets. The high strength steel of KNS-ES was specially designed and fabricated for the particular use as the compressing punches. In this study, very high cycle fatigue tests were performed in the loading type of rotating bending in order to obtain the fundamental S-N property of this steel. Based on experimental results, the S-N property in giga-cycle regime was discussed including the effect of the residual stress on the S-N properties. Consequently, the duplex S-N curves were clearly found, but the surface-induced fractures were often found in the fatigue data belonging to the second S-N curve in the longer life region.
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Sonare, Makrand A., and Manoj Kumar Samantaray. "Pharmaceutical evaluation of Haridra Khanda tablet." Journal of Ayurveda and Integrated Medical Sciences (JAIMS) 5, no. 05 (October 25, 2020): 175–78. http://dx.doi.org/10.21760/jaims.5.5.24.
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Haridra Khanda is unique classical formulation indicated in Udarda, Shitapitta, Kotha. (Urticarial rashes) Khanda or Granules are a comparatively unusual means of administering drugs that possess an unpleasant taste. Haridra Khanda is classical Ayurvedic medicine and available market. Keeping the issue of palatability and invention of patient friendly dosage form in mind, the efforts was made for preparation of tablet out of classical Ayurvedic formulation - Haridra Khanda. The preparation of Haridra Khanda granules were made by standard operative procedure.Binding agents were added to Haridra Khanda . Haridra Khanda was added to mass mixer to ensure homogeneity and easy mixing of all binding agents. And later this mixture was subjected to single punch tablet machine for preparation of 1000 mg tablet. All the Analytical parameters were passed by the Haridra Khanda tablets. Physician can prescribed the tablets to the patients which feel the powdered dosage uncomfortable. Depending on the Roga and Rogibala, tablets of various sizes can be punched and used clinically. This can work more efficiently in pediatric practice.
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Assi, Sulaf, Sarah Rowlands, Panos Liatsis, Mana Al Hamid, Jamila Mustafina, Maitham Ghaly Yousif, Thomas Coombs, and Dhiya Al-Jumeily OBE. "Evaluation of Near-Infrared Chemical Imaging (NIR-CI) for the Authentication of Antibiotics." Currents in Pharmaceutical Research 1, no. 1 (June 28, 2023): 47–69. http://dx.doi.org/10.32350/cpr.11.04.
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Counterfeit medicines represent a public health threat that results in treatment failure and may even have lethal effects in the worst-case scenario. Near-infrared Chemical Imaging (NIR-CI) offers an informative and in-depth tool for several applications in the pharmaceutical industry, particularly for medicine authentication. The current study aimed to authenticate antibiotic tablets using NIR-CI. These tablets were measured non-destructively using a near-infrared microscope within their blister packaging, without their blisters, sectioned and crushed. The results showed that there was no marked difference in measuring the tablets within or without their blister packaging. The mean spectra of tablets showed high correlation coefficient values against the active pharmaceutical ingredient, in case of authentic tablets. On the other hand, counterfeit tablets showed key differences from their authentic alternatives with low correlation coefficient values. More specifically, counterfeit tablets showed poor distribution of the active pharmaceutical ingredient and excipients. It has been proved from the results that NIR-CI process is an authentic process for the evaluation of counterfeit tablets, non-destructively.
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Bracken, Louise, Rober Habashy, Emma McDonough, Fiona Wilson, Joanne Shakeshaft, Udeme Ohia, Tamar Garcia-Sorribes, Abdullah Isreb, Mohamed A. Alhnan, and Matthew Peak. "Creating Acceptable Tablets 3D (CAT 3D): A Feasibility Study to Evaluate the Acceptability of 3D Printed Tablets in Children and Young People." Pharmaceutics 14, no. 3 (February 25, 2022): 516. http://dx.doi.org/10.3390/pharmaceutics14030516.
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3D printing (3DP) has been proposed as a novel approach for personalising dosage forms for children and young people (CYP). Owing to its low cost and the lack of need for finishing steps, fused deposing modelling (FDM) 3DP has been heavily researched in solid dosage forms (SDFs) manufacturing. However, the swallowability and overall acceptability of 3D printed dosage forms are yet to be established. This work is the first to evaluate the acceptability of different sized 3D printed placebo SDFs in CYP (aged 4–12 years). All participants had previously participated in a feasibility study (CAT study) that assessed the swallowability and acceptability of different sized GMP manufactured placebo conventional film-coated tablets, and therefore only attempted to swallow one 3D printed tablet. The participants assessed the swallowability, acceptability, mouthfeel, volume of water consumed, and taste of the sample using a 5-point hedonic facial scale on a participant questionnaire. A total of 30 participants were recruited, 87% of whom successfully swallowed the 3D printed tablet that they attempted to take. Attributes of the 3D printed tablets were scored as acceptable by the following percentage of participants—swallowability (80%), mouthfeel/texture (87%), the volume of water consumed (80%), taste (93%), and overall acceptability (83%). Overall, 77% of children reported they would be happy to take the tablet every day if it was a medicine. Participants were also asked which tablets felt better in the mouth—the film-coated tablets or the 3D printed tablets, and the most popular response (43%) was that both were acceptable. This study shows that FDM-based 3D printed SDFs may be a suitable dosage form for children aged 4–12 years. The results from this feasibility study will be used to inform a larger, definitive study looking at the acceptability of 3D printed tablets in children.
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Dev, Asish, Nihar Lohagaonkar, and Mansi Deshmukh. "Formulation and Evaluation of Floating Bioadhesive Tablet of Candesartan Cilexetil Using 32 Factorial Designs." International Journal of Research and Review 8, no. 10 (October 8, 2021): 93–104. http://dx.doi.org/10.52403/ijrr.20211014.
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Objective: The objective of the work is to formulate candesartan cilexetil floating bioadhesive tablets which can considerably improve the bioavailability of medicine underneath the condition of redoubled continuance of drug in abdomen. Methods: Floating bioadhesive tablet was ready by direct compression of chemical compound like HPMCE15 and Carbopol934p together. Result: After analysis of different evaluation parameter and drug release, F4 batch was selected as promising formulation for delivery of candesartan cilexetil floating bioadhesive tablets with 91.22% drug release at 12th h. Conclusion: Among the further batches, the F4 batch was selected as an optimized batch as a result of the pre-compression and post-compression parameters results area unit satisfactory. Keywords: Candesartan cilexetil, Floating bioadhesive tablets, Polymer, Total floating time.
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Ahmed, Tarek A., Hanadi A. Alotaibi, Waleed S. Alharbi, Martin K. Safo, and Khalid M. El-Say. "Development of 3D-Printed, Liquisolid and Directly Compressed Glimepiride Tablets, Loaded with Black Seed Oil Self-Nanoemulsifying Drug Delivery System: In Vitro and In Vivo Characterization." Pharmaceuticals 15, no. 1 (January 5, 2022): 68. http://dx.doi.org/10.3390/ph15010068.
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Glimepiride is characterized by an inconsistent dissolution and absorption profile due to its limited aqueous solubility. The aim of this study was to develop glimepiride tablets using three different manufacturing techniques, as well as to study their quality attributes and pharmacokinetics behavior. Black seed oil based self-nanoemulsifying drug delivery system (SNEDDS) formulation was developed and characterized. Glimepiride liquisolid and directly compressed tablets were prepared and their pre-compression and post-compression characteristics were evaluated. Semi-solid pastes loaded with SNEDDS were prepared and used to develop three-dimensional printing tablets utilizing the extrusion technique. In vivo comparative pharmacokinetics study was conducted on Male Wistar rats using a single dose one-period parallel design. The developed SNEDDS formulation showed a particle size of 45.607 ± 4.404 nm, and a glimepiride solubility of 25.002 ± 0.273 mg/mL. All the studied tablet formulations showed acceptable pre-compression and post-compression characteristics and a difference in their in vitro drug release behavior. The surface of the liquisolid and directly compressed tablets was smooth and non-porous, while the three-dimensional printing tablets showed a few porous surfaces. The inner structure of the liquisolid tablets showed some cracks and voids between the incorporated tablet ingredients while that of the three-dimensional printing tablets displayed some tortuosity and a gel porous-like structure. Most of the computed pharmacokinetic parameters improved with the liquisolid and three-dimensional printed tablets. The relative bioavailabilities of the three-dimensional printed and liquisolid tablets compared to commercial product were 121.68% and 113.86%, respectively. Therefore, the liquisolid and three-dimensional printed tablets are promising techniques for modifying glimepiride release and improving in vivo performance but more clinical investigations are required.
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Symonenko, N. А., O. S. Shpychak, O. S. Kukhtenko, Ye A. Bezrukavyi, and H. B. Yurieva. "Justification of the choice of excipients during the development of the composition of “Pastinocard” tablets." Current issues in pharmacy and medicine: science and practice 16, no. 3 (November 3, 2023): 236–43. http://dx.doi.org/10.14739/2409-2932.2023.3.287001.
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The aim of the work is to justify the choice of excipients as components for the cardioprotective medicine “Pastinocard” tablets based on the domestic raw material of cultivated parsnip herb thick extract (CPHTE). Materials and methods. Experimental test samples of mixtures of the plant substance of domestic origin CPHTE with groups of excipients, approved for medical use, were used as the object of research. Results. We conducted experimental research by a mathematical planning method called the Greek–Latin square. In this study, we investigated how 16 different auxiliary substances affected the pharmacotechnological properties of tableting masses and tablets made from PPTEG with cardioprotective properties. Our goal was to determine the optimal composition and manufacturing process for a medication, specifically “Pastinocard” tablets. We also developed project plans for manufacturing regulations and quality control methods, which we successfully tested in the industrial production setting at Pharmaceutical Company “Zdorovye”, LTD in Kharkiv. Conclusions. The formulation for cardioprotective tablets, designated as “Pastinocard”, has been both theoretically justified and experimentally developed by domestic CPHTE raw materials. These research findings have been instrumental in crafting the regulatory documentation for quality control and the production processes of the resulting tablet medication.
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Geller, M. J. "Fragments of magic, medicine, and mythology from Nimrud." Bulletin of the School of Oriental and African Studies 63, no. 3 (January 2000): 331–39. http://dx.doi.org/10.1017/s0041977x00008429.
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A new volume of literary texts from Nimrud has been in gestation for a very long time. Tablets were first found in Max Mallowan's excavations at Nimrud in 1949, with many more tablets found in subsequent seasons. In 1963 the decision was made to publish all the literary tablets from the Nabû Temple in hand copy, and this effort has finally culminated in the form of Literary texts from the Nabû temple, edited by J. A. Black and D. J. Wiseman (Cuneiform Texts from Nimrud 4, 1998). As is so often the case with the publication of new literary texts, these copies often solve many problems and create just as many new ones for editors of texts; many of the copies could benefit from collation. Furthermore, the catalogue describing the tablets is extremely sparse, and much more could have been done by the editors to identify the tablets and note published duplicates. Nevertheless, the volume makes a valuable contribution to the field of Assyriology by publishing a large number of literary texts in cuneiform copy.
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Nnamani, N. D., I. S. Okafor, and O. N. Ume. "Evaluating the effect of spherical crystallization of acetylsalicylic acid crystal and crystal agglomeration of Manihotesculenta starch on direct compression tablet properties." Bayero Journal of Pure and Applied Sciences 13, no. 2 (December 15, 2021): 29–35. http://dx.doi.org/10.4314/bajopas.v13i2.4.
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Spherical crystallization and crystal agglomeration have been used to optimize compact crystals and functional properties of powders. The aim of this work is to evaluate the effect of spherical crystallization of acetylsalicylic acid crystals and crystal agglomeration of Manihotesculenta starch on direct compression tablet. Typical spherical crystallization using three solvent system of water–ethanol-carbon tetrachloride was used to produce spherical acetylsalicylic acid. Salting-out agglomeration of gelling in water and salting in ethanol was used to produce starch-xerogel from Manihotesculenta starch. The modified products were qualified using FT-IR analysis. The analysis results showed that modification did not alter chemical nature of the products. Acetylsalicylic acid tablets were formulated using spherical-crystallizedacetylsalicylic acid with 5 and 10% w/w starch-xerogel respectively, and using acetylsalicylic acid with 5 and 10% w/w of starch, and microcrystalline cellulose respectively. The physicochemical properties of the tablets were evaluated. Astatistical 23 factorial design of the tablet properties at 5% level of significance showed that the effects of the variables are different. Theacetylsalicylic acid tablets formulated from direct compression of spherical-crystallizedacetylsalicylic acid with 5 % w/w starch-xerogel produced quality tablets comparable to standard tablets from direct compression of acetylsalicylic acid with10 % w/w microcrystalline cellulose. Spherical crystallization and crystal agglomeration optimized the compact crystals of starch and acetylsalicylic acid, and improved direct compression properties of the crystals, and drug release from tablet.
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Norlailasari, Eka Rani, Mariani Mariani, and Evy Noorhasanah. "Analysis of Nursing Care in Adolescents with Anemia with the Application of Monitoring and Education Interventions for Giving Blood Added Tablets at Teluk Dalam Health Center Banjarmasin." AURELIA: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia 2, no. 2 (July 4, 2023): 631–38. http://dx.doi.org/10.57235/aurelia.v2i2.687.
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Young women, who tend to become mothers will be more affected by anemia because they tend to get pregnant and give birth. blood supplement tablet supplementation program for young women, one of the government's efforts to ensure adequate iron intake to prevent anemia. Before administering Blood Supplement Tablets, adolescents should be given information about anemia in Blood Supplement Tablets, as well as guidance or supervision during the administration of Blood Supplement Tablets. The purpose of this research is to describe the results of monitoring and educating the administration of blood supplement tablets. The writing method is in the form of case studies on adolescents with anemia. The results of this case study showed an increase in hemoglobin and hematocrit levels. The control card is filled in according to the date of taking the medicine and signed by the parents. With this case study, it is hoped that nursing interventions related to the method of increasing hemoglobin levels in young women with anemia can be developed.
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Davidson, Sarah Melati, Vio Herawati Br Tampubolon, and Rifatolistia Tampubolon. "Pengetahuan, Sikap, Dukungan dan Persepsi Konsumsi Tablet Tambah Darah (TTD) pada Mahasiswi Fakultas Kedokteran dan Ilmu Kesehatan Universitas Kristen Satya Wacana." Jurnal Kesehatan Indonesia 14, no. 1 (November 23, 2023): 15. http://dx.doi.org/10.33657/jurkessia.v14i1.843.
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Iron-deficiency anemia is a significant nutritional concern in Indonesia. This type of anemia is more common among children, adolescents, pregnant and breastfeeding women, and low-income workers. Although students from the Faculty of Medicine and Health Sciences have been informed about anemia and iron (Fe) tablets, there are still many who have not started taking them. This research aims to describe the knowledge, attitudes, support, and perception of Fe tablet consumption among female students at this University. The research used a descriptive-analytic method with a cross-sectional approach. The study population consisted of 93 female students from the 2021 batch, specifically from the Faculty of Medicine and Health Sciences. The research sample was selected based on inclusion and exclusion criteria. A questionnaire was used as the research instrument and analyzed using univariate analysis. The findings revealed that only 22.6% of the respondents reported consuming Fe tablets, while 77.4% did not. Twenty-six respondents displayed a good level of knowledge, and 31 had a positive attitude. The level of support from family and peers was low, with only 22 respondents reporting family support and 30 reporting peer support. Despite not taking iron tablets regularly, the respondents' knowledge, attitudes, perception of benefits, and constraints were generally in a good category. However, the support variable obtained still needs improvement as it remains in the low category, which contributes to the irregular intake of iron tablets by the respondents.
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Kreft, Klemen, Zoran Lavrič, Tijana Stanić, Petra Perhavec, and Rok Dreu. "Influence of the Binder Jetting Process Parameters and Binder Liquid Composition on the Relevant Attributes of 3D-Printed Tablets." Pharmaceutics 14, no. 8 (July 28, 2022): 1568. http://dx.doi.org/10.3390/pharmaceutics14081568.
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Binder jetting has the potential to revolutionize the way we produce medicine. However, tablets produced by binder jetting technology can be quite fragile and hard to handle. In this study, the printing process and ink composition were examined to optimize the mechanical properties of tablets. A model formulation containing the ketoprofen drug was developed and used as a base for optimization. Firstly, important printing parameters were identified with a fractional factorial design. Saturation and layer height critically influenced selected tablet properties. Relevant process parameters were optimized for tablet mechanical strength by using the D-optimization DoE approach. The best mechanical properties were achieved when saturation was set to 1 and layer height to 150 µm. On the other hand, binder ink composition did not appear to impact tablet mechanical strength as much as process parameters did. Three ethanol-water mixtures were tested at three tablet strength levels and no definitive conclusions could be drawn. The binder jetting process can be wasteful, especially if the unbound powder cannot be reused. To determine the suitability of powder blend recycling, the ketoprofen content was measured for 27 subsequent batches of tablets. While the trendline did indicate a slight reduction in ketoprofen content, the powder blend reuse can nevertheless be employed.
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Mackenzie-Smith, L., H. Wüthrich, and R. Laoun. "P558 Medication Preference of 400 patients with mild to moderate Ulcerative Colitis." Journal of Crohn's and Colitis 15, Supplement_1 (May 1, 2021): S521—S522. http://dx.doi.org/10.1093/ecco-jcc/jjab076.679.
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Abstract Background Patient adherence to his/her medication is a major challenge in the successful management of any chronic disease and it is a major challenge in Ulcerative Colitis (UC). Patient adherence is thought to be closely related to patient preference of medication and formulation used. We wanted to investigate the patient preference between tablets and granules of mesalazine and compare it to the physician perception. Methods We conducted an online survey between November and December 2020 in 4 EU countries (France, Germany, Spain, and the UK). In addition to patients and physicians from these 4 countries, the questionnaire was also addressed to IBD nurses from the UK. Patients were included if they had mild or moderate UC. Results 400 patients, 160 physicians, 20 nurses participated in this survey. 68% patients were taking tablets and 32% granules. 62% of the patients who answered the survey admitted their preference for tablet while only 38% for granules (figure 1). 63.9% of the physician would prefer to prescribe tablets for their patients. Physicians stated that patients tend to be more adherent to tablets than granules (69% vs. 31%) and patients tend to find this the most convenient formulation. When patients were asked about some positive attributes of tablets, the highest agreement was with “good size, easy to see and handle” (7.6/10) while for granules “no problem to take granules in public” (8.4/10). When asked about some negative attributes of tablets, the highest agreement was with “I would like to take fewer each day” (6.1/10) and “I wish I could take fewer at a time” (5.4/10) while for granules “you have to drink a lot of liquid for them to go down” (6.6/10) and “I wish I could take fewer” (5.1/10). 50 patients were switched to tablets after trying granules first and 45 to granules after trying tablets. Treatment changes were initiated mainly by the physician (57% of the time). Patients switching to granules almost all agreed that they wanted to take fewer tablets each day (8.1/10). Patients switching to tablets complained about the need to drink a lot of water with granules (6.5/10) or to mix them with food (6.3/10). This is also reflected in the way patients take tablets (figure 2) or granules (figure 3). While 71% of the patients swallow the tablets whole only 35% of the patients swallow all the granules at once. 37% mix the granules with food or liquid, 20% divide the portions to be able to swallow them and 8% chew the granules. Asked about adherence, only 21% (85 patients) admitted taking less than 80% of prescribed medication. Conclusion The majority of the patients prefer the tablet formulation. A high strength tablet overcoming the pill burden could be a good solution to address patient expectations.
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Emira, Ezi, Anggi Dheana Karin, Nur Afni, and Lina Handayani. "Pengaruh Pendidikan Kesehatan terhadap Kepatuhan Konsumsi Tablet Fe pada Ibu Hamil: Literature Review." Jurnal Kesehatan Masyarakat Indonesia 17, no. 1 (March 30, 2022): 12. http://dx.doi.org/10.26714/jkmi.17.1.2022.12-17.
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Background: The incidence of anemia in pregnant women has reached 48.9%. Some of the factors that cause anemia include poor adherence to Fe tablet consumption, mainly due to the low knowledge and attitudes of pregnant women regarding the importance of consuming Fe tablets during pregnancy. This systematic review aims to determine the effect of health education on pregnant women on adherence to consuming Fe tablets. Methods: Using an in-depth content analysis method on selected articles using the keywords “Compliance, Iron Supplements, pregnant women, health education” in the PUBMED and ProQuest databases. Articles are selected in stages using the PRISMA Appraisal Tool. Results: From 438 articles, finally 5 articles were obtained. From the five final articles, it was found that there was an effect of health education on the knowledge and attitudes of pregnant women about Fe tablets and that there was an effect of health education on the compliance of pregnant women in consuming Fe tablets. Conclusion: Health education for pregnant women is very influential on adherence to Fe tablet consumption, although if it is done with low intensity it has little effect. This finding is important for health educators to focus on updating strategies and developing health education practices to increase knowledge and compliance of pregnant women in consuming Fe tablets.
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Kinsella, Anna. "P24 Does an interdisciplinary approach to tablet/capsule swallowing increase the uptake of or transition to solid oral dosage forms in paediatric patients with ALL acute lymphoblastic leukaemia?" Archives of Disease in Childhood 105, no. 9 (August 19, 2020): e18.2-e19. http://dx.doi.org/10.1136/archdischild-2020-nppg.33.
Full textAbstract:
AimMost paediatric formulations produced for children are generally liquids or powders for reconstitution. Palatability of liquid formulations is often cited as a barrier to medication adherence.1 An alternative to liquid formulations is the conventional solid oral dosage forms, such as tablets or capsules. However, another barrier faced by paediatric patients is the inability to swallow tablets.2 This presents a number of challenges for children with ALL, as treatment contains a phase of extended ‘maintenance’ therapy to prevent relapse. This involves taking oral chemotherapy daily, ± monthly chemotherapy injections, over 2 years for girls and 3 years for boys. Prior to 2014, paediatric oncology pharmacists would work with children refusing to take or struggling with their liquid medicines. It was a simple approach, where ‘tic-tacs®’ were used and swallowinSg these was practiced together. Through education sessions and informal discussions with nursing, medical and play therapists, a culture evolved in 2014 whereby medicine taking was not just the responsibility of pharmacy but of the wider team. Nursing and medical staff were actively involved identifying families that needed support with their medicines. Display boards were created advertising the option of tablets for different medicines and highlighting the different swallowing techniques. The play specialists became ‘Medicine Champions’ using novel approaches to provide children with the tools, confidence and ability to take tablets. Children who successfully mastered swallowing tablets were presented a ‘star award’ certificate for their achievement. Photographs of children with their certificates were displayed in the outpatient clinic.MethodPaediatric patients diagnosed with ALL between 2012 and 2017 were retrospectively identified using chemotherapy prescriptions, patient’s medical notes and electronic patient medical records. Data collected included age at diagnosis, formulation choice initiated on and whether patients switched formulations during the course of their treatment. Children were excluded for the following reasons: if they had a history of swallowing difficulties/choking, if the child had learning difficulties or if the child was deceased.Results172 patients were diagnosed with ALL between 1st January 2012 and 31st December 2017; 14 patients were excluded (13 deceased,1 learning difficulties). The percentage of children aged 3–12 years taking tablets in 2012 and 2013 was 41% (n=7) and 20% (n=2) respectively. This increased to 69% (n=11) in 2014, remained consistently above 60% in 2015/2016 and increased again to 76% (n=14) in 2017. Between 2014 and 2017, 100% of patient’s ≥ 6 years took their oral chemotherapy as tablets. Over 65% of all patients 0 – 18 years were taking liquids in 2012/2013. From 2014 to 2017 less than 50% of all patients each year were taking liquids. No patients were identified as switching back from tablets to liquid.ConclusionThis study supports an interdisciplinary approach to tablet taking. By bringing together different members of staff with the necessary knowledge, skills and experiences, we were able to provide families with the tools and confidence to support their child in mastering the technique of swallowing tablets, increasing the number of patients initiating on or transitioning to solid oral dosage forms by approximately 50%.ReferencesBaguley D, et al. Prescribing for children – taste and palatability affect adherence to antibiotics: a review. Arch Dis Childhood, 2012;97:293–7.Polaha J. Dalton WT III, Lancaster BM. Parental report of medication acceptance among youth: implications for everyday practice. South Med J. 2008;101:1106–1112.