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Academic literature on the topic 'Tablets (Medicine)'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 July 2024

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Journal articles on the topic "Tablets (Medicine)"

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Mubeen, Ahamed Mueen, Atchaya A, Ilakiya S, Rasitha Banu U, Rojamani K, and Vijayalakshmi S. "Comparative standardization studies of marketed Polyherbal tablets." International Journal of Multidisciplinary Research and Growth Evaluation 4, no. 2 (2023): 346–50. http://dx.doi.org/10.54660/.ijmrge.2023.4.2.346-350.

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Siddha and Ayurvedha is one of the oldest traditional systems of medicine in the world. There are different formulations which are adequately increase delivery of the drug to our body sites; one of basic formulation is tablet. Tablet is one of the conventional formulations in solid oral dosage form, which are usually used in traditional system of medicines and allopathic medicines. Allopathic formulations like tablets usually maintaining their standards based on the various pharmacopoeia but Ayurvedhic and Siddha proprietary medicines shows lots of troubles in their standardization parameters, why because they consist of multiple herbal crude drugs in one formulation, so it should be prescribed with proper standardization parameters. The present work deals with to evaluation two marketed formulation by performing basic quality control parameters of tablets such as Organoleptic properties, Weight variation, Hardness, Friability, Disintegration of herbal tablets {Alsactil [A] and Alsarex [B]} From the analysis of above parameters, results was observed and all the parameters of both drugs passes the test, within the reference values.
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Bracken, Louise, Emma McDonough, Joanne Shakeshaft, Fiona Wilson, Udeme Ohia, Mohamed A. Alhnan, Rober Habashy, Robert Forbes, and Matthew Peak. "SP8 Creating acceptable tablets 3D (CAT 3D): a feasibility study to evaluate the mouthfeel of 3D printed tablets in children and young people." Archives of Disease in Childhood 105, no. 9 (August 19, 2020): e5.1-e5. http://dx.doi.org/10.1136/archdischild-2020-nppg.8.

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AimTo evaluate the feasibility of a study investigating the mouthfeel of different sized 3D printed placebo solid dosage forms (SDFs) in children and young people (CYP) aged 4–12 years.MethodAll participants in the CAT 3D Study had previously participated in the Creating Acceptable Tablets (CAT) Study, a feasibility study which assessed the swallowability and acceptability of different sized placebo tablets, and therefore only attempted to swallow one 3D printed tablet. If the participant had successfully swallowed all three tablet sizes in the CAT Study (6 mm, 8 mm, 10 mm) they were then randomised to receive any of the 3D printed tablets – 6 mm, 8 mm or 10 mm diameter. If a participant had not successfully swallowed all tablet sizes, they were allocated a 3D printed tablet of equal size to the largest tablet they had successfully swallowed in the CAT Study. Following informed consent, participants were shown a short video demonstrating how to swallow a tablet. Participants were then provided with the sample 3D tablet and 150 mL of still water in a cup. The volume of water required to swallow the tablet was measured, and further water was provided, where requested. The researcher observed and recorded the child’s facial expressions as they swallowed the tablet1, and an internal inspection of the mouth was conducted by the researcher to identify any residue or non-swallowed tablet.2 The participants assessed the swallowability, acceptability, mouthfeel and taste of the sample using a 5-point hedonic facial scale on a participant questionnaire. Faces 1–3 on the hedonic scale were deemed acceptable to the participant. The participants were also asked if the 3D printed tablet was a medicine, would they be willing to take it every day. In addition, they were asked which tablet felt better in the mouth as a comparison of mouthfeel between the GMP manufactured coated tablets (CAT study tablets) and the 3D printed tablets.ResultsA total of 30 participants were recruited to the CAT 3D Study, 87% of whom successfully swallowed the 3D printed tablet that they attempted to take. Attributes of the 3D printed tablets were scored as acceptable by the following percentage of participants – swallowability (80%), mouthfeel/texture (87%), volume (80%), acceptability (83%) and taste (93%). 77% of children advised they would be happy to take the tablet every day if it were a medicine. Participants were also asked which tablets felt better in the mouth – the CAT tablets or the 3D printed CAT 3D tablets, and the most popular response was that both felt ok (43%).ConclusionsThe data from this study shows that 3D printed SDFs may be a suitable dosage form for children aged 4–12 years. The results from this feasibility study will be used to inform a larger, definitive study looking at the mouthfeel of 3D printed tablets in children.ReferencesZeinstra GG, Koelen MA, Colindres D, et al. Facial expressions in school-aged children are a good indicator of ‘dislikes’, but not of ‘likes’. Food Quality and Preference 2009 December 2009; 20:620–624.Klingmann V, Spomer N, Lerch C, et al. Favorable acceptance of mini-tablets compared with syrup: a randomized controlled trial in infants and preschool children. The Journal of Pediatrics 2013 December 2013;163:1728–1732.e1.
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Wang, Yifei, Zhisheng Wu, Zhaoyi Wang, Manfei Xu, Xinyuan Shi, and Yanjiang Qiao. "Rapid analysis of spatial distribution of PVPP and hardness of Yinhuang dispersible tablets by NIR-CI." Journal of Innovative Optical Health Sciences 09, no. 02 (March 2016): 1550016. http://dx.doi.org/10.1142/s1793545815500169.

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The present study aimed at investigating the relationship between tablet hardness and homogeneity of different Yinhuang dispersible tablets by near-infrared chemical imaging (NIR-CI) technology. The regularity of best hardness was founded between tablet hardness and the spatial distribution uniformity of Yinhuang dispersible tablets. The ingredients homogeneity of Yinhuang dispersible tablets could be spatially determined using basic analysis of correlation between analysis (BACRA) method and binary image. Then different hardnesses of Yinhuang dispersible tablets were measured. Finally, the regularity between tablet hardness and the spatial distribution uniformity of Yinhuang dispersible tablets was illuminated by quantifying the agglomerate of polyvinyl poly pyrrolidone (PVPP). The result demonstrated that the distribution of PVPP was unstable when the hardness was too large or too small, while the agglomerate of PVPP was smaller and more stable when the best tablet hardness was 75[Formula: see text]N. This paper provided a novel methodology for selecting the best hardness in the tabletting process of Chinese Medicine Tablet.
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Shyrko, A. Yu, M. M. Vasenda, L. I. Будняк, and O. O. Pokotylo. "The choice of excipients to obtain tablets based on the Primula denticulate Smith. Extract by wet granulation." Ukrainian biopharmaceutical journal, no. 1(66) (April 12, 2021): 4–9. http://dx.doi.org/10.24959/ubphj.21.296.

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Introduction. Herbal medicines are increasingly being used in the treatment of various diseases. Significant number of resources, high-level availability and the possibility of cultivation have provided high prospects of plant raw materials in the development of new herbal medicines. Primula denticulate Smith. is one of the most interesting medicinal plant raw materials source in modern medicine and pharmacy with the wide spectrum of pharmacotherapeutic action, that is mainly used only in traditional medicine. Thus, nowadays the development of new and effective medicines based on Primula denticulate Smith. in tablet dosage form is the topical task of pharmacy. The aim of the work. To study the influence of excipients on the pharmaco­technological parameters of tablets with Primula denticulate Smith, are obtained by wet granulation method and to substantiate the choosing of the best excipients by the method of mathematical planning of the experiment. Materials and Methods. It was used a self-prepared dense extract of Primula denticulate Smith. and excipients, which are complied with the requirements of State Pharmacopoeia of Ukraine in terms of pharmaco-technological quality parameters, for developing tablets. The hyper Greek-Latin square 4x4 was used to study the four qualitative factors. Results and Discussion. In the course of the experiment, it was determined the dependence of pharmaco­technological parameters (friability, resistance to crushing and disintegration of tablets) on type of excipients. It was selected excipients with the optimal pharmaco-technological parameters for further research the tablets quality. Conclusions. According to the method of mathematical planning of the experiment, it’s chosen the optimal excipients for obtaining tablets based on dense extract of Primula denticulate Smith. Considering the investigated pharmaco-technological properties (friability, resistance to crushing and disintegration of tablets) the qualitative composition of excipients for obtaining tablets by the method of wet granulation was determined: Avicel PH - 105 and MCC 101, croscarmellose sodium, colloidal anhydrous silicon dioxide, magnesium stearate and Prosolv 90.
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Bhatia, Ritika, Rakesh Goyal, and Dilip Agarwal. "Process Validation of Paracetamol tablet as per ICH guidelines." International Journal of Medical and Biomedical Studies 7, no. 6 (June 12, 2023): 11–23. http://dx.doi.org/10.32553/ijmbs.v7i6.2713.

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Process validation is an integral part of pharmaceutical manufacturing, ensuring that tablets are consistently produced with quality and efficacy in line with regulatory requirements. The International Council for Harmonization ICH) provides guidelines for the systematic validation of manufacturing processes. This research article presents a comprehensive study on process validation for Paracetamol tablets following the ICH guidelines. The article focuses on various aspects of the validation process, including process design, qualification, and continued process verification, with specific emphasis on Paracetamol tablet manufacturing. Experimental studies were conducted to characterize the critical process parameters and assess their impact on the tablet's quality attributes. The article also discusses the use of statistical analysis techniques for data evaluation and demonstrates the establishment of a robust validation protocol for Paracetamol tablet manufacturing. Through the application of the ICH guidelines, this research contributes to ensuring the consistency and reliability of Paracetamol tablets, enhancing patient safety and meeting regulatory expectations. Keywords: Process validation, ICH guidelines, Critical process parameters, Critical Process Attribution, Statistical analysis, and validation protocol;
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Sanada, Tomoko, Myu Ohnishi, Naoko Yoshida, Kazuko Kimura, and Hirohito Tsuboi. "Quality assessment of Diflucan® tablets distributed online: Diflucan® distributed online." Medicine Access @ Point of Care 5 (January 2021): 239920262110020. http://dx.doi.org/10.1177/23992026211002089.

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Background: Falsified medical products have been reported worldwide. Falsified medicines with poor quality are a potential health hazard. Some Internet sites advertise fluconazole (Diflucan®), an antifungal medicine used to treat deep mycoses, as “female Viagra®.” Aim: The aim of this study was to investigate the authenticity and quality of Diflucan® tablets distributed on the Internet. Methods: We ordered Diflucan® tablets via the Internet and evaluated them by visual observation, authenticity investigation, quality evaluation (quantity of the active pharmaceutical ingredient, content uniformity, and dissolution), and near-infrared and Raman scattering spectroscopy. Results: We obtained 11 samples of Diflucan® tablets from all 11 Japanese Internet sites identified in our search. Of 11 sites, 7 advertised fluconazole as having effects on female sexual function. Ten of the Diflucan® samples were confirmed as genuine and one sample was falsified. The genuine Diflucan® samples met the specifications of all quality evaluations. The packaging, size, and color of the falsified Diflucan® sample obtained in this study differed from the authentic Diflucan® tablet. The falsified Diflucan® sample obtained in this study did not contain fluconazole and instead contained what appeared to be sildenafil citrate. The spectra of the falsified Diflucan® tablet obtained in this study differed from the authentic Diflucan® tablet in near-infrared and Raman scattering spectroscopy. Conclusion: We confirmed that one falsified Diflucan® tablet was distributed online. Thus, continued measures against falsified medicines are required.
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Karmakar, Palash, and Md Golam Kibria. "In-vitro comparative evaluation of quality control parameters between paracetamol and paracetamol/caffeine tablets available in Bangladesh." International Current Pharmaceutical Journal 1, no. 5 (April 7, 2012): 103–9. http://dx.doi.org/10.3329/icpj.v1i5.10282.

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Paracetamol is a widely used non-prescription analgesic and antipyretic medicine. The study was conducted to assess the comparative in-vitro quality control parameters through the evaluation of weight variation, hardness, friability, disintegration time and dissolution profile between the commercially available tablet brands of paraceta-mol and paracetamol/caffeine combination in Bangladesh. Tablets of five top level manufacturers those have both of the formulations were evaluated in two groups. Both similarities and dissimilarities were found between the groups. All tablets either paracetamol (1.07 to 2.14%) or paracetamol/caffeine (0.98 to 2.09%) showed acceptable weight variation and friability (below 1%). Formulations were somewhat different in their hardness, disintegration time and dissolution profile. All tablets of paracetamol/caffeine were found harder than paracetamol tablets of the same manufacturer. 1 out of 5 for paracetamol and 3 out of 5 for paracetamol/caffeine tablets exceeded the limit of tablet hardness or crushing strength. The disintegration time in 0.1N HCl of paracetamol tablet brands (24 seconds to 4 minutes 52 seconds) were less than the paracetamol/caffeine (6 minutes 33 seconds to 17 minutes 43 seconds) brands. On the other hand in phosphate buffer, pH 7.4, paracetamol/caffeine tablets dissolved quickly and showed better release profile than tablets containing only paracetamol. It can be concluded that standard quality control parameters always should be maintained not only for paracetamol or its combination but also for all kinds of medicine for getting better drug products.DOI: http://dx.doi.org/10.3329/icpj.v1i5.10282International Current Pharmaceutical Journal 2012, 1(5): 103-109
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Bracken, Louise, Emma McDonough, Samantha Ashleigh, Fiona Wilson, Joanne Shakeshaft, Udeme Ohia, Punam Mistry, et al. "Can children swallow tablets? Outcome data from a feasibility study to assess the acceptability of different-sized placebo tablets in children (creating acceptable tablets (CAT))." BMJ Open 10, no. 10 (October 2020): e036508. http://dx.doi.org/10.1136/bmjopen-2019-036508.

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ObjectiveFeasibility study to investigate the acceptability of different-sized placebo tablets in children aged 4–12 years.Design and settingClinical Research Facilities, inpatient wards and outpatient clinics within a Regional Paediatric Hospital and/or District General Hospital. Healthy children and National Health Service (NHS) patients were asked to swallow three placebo tablets: 6 mm, 8 mm and 10 mm, smallest to largest. The researcher observed children’s facial expressions and behaviours on swallowing and measured the volume of water consumed. Participants completed a questionnaire about the overall acceptability; including swallowability, taste and volume of water consumed. For analysis, participants were stratified by age: 4–8 years and 9–12 years.ResultsThe feasibility study led to an estimated recruitment rate of 0.8% for NHS inpatients and 211 healthy children over a 1-year period. In total, 55 participants were recruited, 30 to the younger group, of which 77% had never taken a tablet before. 84% of the 25 older children had previously taken a tablet. All participants attempted to swallow the smallest sized tablet. The children aged 4–8 years found the larger tablets easier to swallow, however the older children found little difference between the tablet sizes. The younger children required more water to swallow each tablet size compared with the older children where an increasing volume of water was consumed as tablet size increased. Taste was rated highly for both age groups. The 8 mm tablets were deemed the most acceptable tablet size by all participants.ConclusionTablets are potentially an acceptable formulation for children aged 4–12 years. Most children aged 4–8 years who attempted to swallow tablets successfully did so. Recruitment of NHS inpatients to medicine acceptability studies is challenging, however, recruitment of children of staff proved an effective strategy. Valuable lessons have been learnt from this feasibility study which will inform the design of a larger definitive trial.
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DuBuske, Lawrence. "Efficacy and safety of sublingual allergen immunotherapy." Allergy and Asthma Proceedings 43, no. 4 (July 1, 2022): 272–80. http://dx.doi.org/10.2500/aap.2022.43.220036.

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Sublingual immunotherapy (SLIT)-tablets represent a new allergen immunotherapy option for clinicians. In North America, there are five SLIT-tablets approved for the treatment of allergic rhinoconjunctivitis (ARC). No SLIT-drops products are currently approved in the United States or Canada. This work reviewed the efficacy of the timothy grass SLIT-tablet, five-grass SLIT-tablet, ragweed SLIT-tablet, house-dust mite SLIT-tablet, and tree SLIT-tablet in patients with ARC. All the SLIT-tablets showed consistent clinical efficacy for the treatment of ARC in large, double-blind, placebo-controlled trials, including for both patients who were monosensitized and those who were polysensitized. Treatment with house-dust mite SLIT-tablet has shown efficacy in patients who are pollen sensitized during their respective pollen seasons. In contrast to SLIT-tablets, efficacy studies of SLIT-drops show high heterogeneity of treatment effect. Although data are scarce, data that compared the efficacy of SLIT-tablets versus ARC pharmacotherapy generally indicated that SLIT-tablets had a greater benefit than pharmacotherapy when compared with placebo, particularly for perennial ARC. When compared with subcutaneous immunotherapy, analysis of these data indicated that SLIT-tablets had a benefit over subcutaneous immunotherapy in regard to safety but somewhat less benefit in regard to efficacy. The safety of SLIT-tablets has been well documented, and a U.S. Food and Drug Administration class label with safety considerations is present in the prescribing information for all SLIT-tablets. No new safety signals have been observed after reinitiating SLIT-tablets after a short treatment interruption.
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Mawson, Charlotte. "7 Development of a leaflet to teach children to swallow tablets." Archives of Disease in Childhood 103, no. 2 (January 19, 2018): e2.47-e2. http://dx.doi.org/10.1136/archdischild-2017-314585.7.

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AimIn paediatric pharmacy a wide range of medications are used, which are often not available in formulations suitable for children. We wanted to design a tool that would enhance our patients’ experience of medication taking as well as improving accessibility to medicines, palatability and ease of administration.MethodThe European Medicines Agency advises that ‘for chronic diseases, the acceptability of tablets in children may be improved by adequate training’.1 Among others a study has shown that almost half of two year olds could swallow a 3 mm tablet, increasing to 85% in 5 year olds.2A leaflet was suggested as the best way to teach our patients and their parents how to swallow tablets as it could be widely distributed. It was developed with a working group of paediatric clinical psychologists and a paediatric pharmacist. The leaflet aims to be encouraging and provide practical tips and advice. It offers seven different techniques for swallowing tablets which were adapted from web-based advice and previous cases. The leaflet was piloted in a small number of patients and they were given a questionnaire.ResultsTen questionnaires were returned, with patients’ ages ranging from 5 to 17. All the patients said that they would now be taking all or some of their medication as tablets. All of the techniques were tried by 2 or more patients and each technique was successful for at least 1 child. The most popular method was the ‘big gulp method’ which worked for 8 patients. This involves swirling the tablet around the mouth for 10 s with as much water as possible and then taking a large gulp until all the water and the tablet have gone.Positive feedback for the leaflet included ‘feels grown up being able to take a tablet’, taking tablets is ‘easier’ and ‘quicker’; one patient wished they had been given the leaflet sooner. Parents also fed back that ‘there was no longer a fight to take medicines’ and ‘it’s much easier for school to manage’.ConclusionThe findings have shown that this is a very successful and useful tool. It allows children and their families to take ownership of their medicine taking. To enable more patients to benefit, further engagement from multidisciplinary teams e.g. play specialists, is needed. In the long-term this leaflet could be used to proactively start patients on tablets rather than reactively, creating potential cost savings and a reduction in the use of unlicensed medicines and specials.ReferencesEuropean Medicines Agency. Guideline on pharmaceutical development of medicines for paediatric use2013. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2013/07/WC500147002.pdf [Accessed: 28 July 2016].Thomson SA, Tuleu C, Wong ICK, et al. Minitablets: New modality to deliver medicines to preschool-aged children. Paediatrics2009;123(2):235–238.
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Dissertations / Theses on the topic "Tablets (Medicine)"

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Rashed, Abdulhameed M. "Characterisation and profiling of ecstasy tablets." Thesis, University of Glasgow, 2000. http://theses.gla.ac.uk/6339/.

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In addition to identifying the presence of a specific controlled drug in an exhibit and measuring its concentration, forensic drug laboratories are requested in certain cases or as a routine to provide additional information that may be helpful to the investigation process. On the basis of their chemical and physical characteristics, seized drugs may be profiled and linked to common sources or routes of distribution. Chapter 1 is an introduction to the illicit drug production from cultivation to manufacturing and trafficking. Chapter 2 describes the role of the drug chemist and includes characterisation of seizures, that is identification, quantification, and comparison of illicit drugs. Chapter 3 provides a literature review of the different analytical methods used in the area of drug profiling. This project has been on the subject of drug profiling with focus on the ringsubstituted amphetamine, 3,4 methylenedioxymethamphetamine (MDMA) or ecstasy as it is widely called. Among the main objectives of this study was the development and optimisation of a new extraction procedure, solid phase extraction, for impurities in seized ecstasy tablets. The instrumental analysis of impurities found in ecstasy tablets usually require a preliminary process to extract, isolate, and concentrate these impurities from the total tablet content. In the process, interfering materials are removed, and the required substances are concentrated into a solvent that is suitable for introduction into the instrument. Chapter 4 describes the development of a solid phase extraction (SPE) procedure and also an evaluation of a comparison procedure of liquid-liquid extraction (LLE) and SPE for extracting impurities in ecstasy tablets for profiling purposes. Solid phase extraction of impurities in ecstasy tablets proved to be more efficient than the traditional liquidliquid extraction. SPE provided impurity peaks with higher intensities than did LLE and a shorter extraction time. Another area of research was the use of infrared technology as an additional tool for profiling ecstasy tablets as seen in Chapter 5. Infrared method can serve as an elimination or screening step for gross clustering or grouping of exhibits. In chapter 6 the synthesis of MDMA using different synthetic routes to acquire authentic samples of impurities which are usually present in street samples were performed. These authentic samples were analysed and their mass spectra and retention indices were used to identify impurities in actual street samples to determine their route of synthesis. In chapter 7 ecstasy tablets confiscated within the UK were analysed to establish their route(s) of synthesis using the data of the authentic compounds synthesised earlier. The main contributions of this project were: 1. Developing a solid phase extraction procedure as an alternative to the conventional liquid-liquid extraction procedure. SPE provided extraction with no cross contamination of phases and no emulsion problem, as with LLE, due to the presence of fatty acids in ecstasy tablets. 2. Developing a simple and fast infrared method as a screening or elimination tool for ecstasy profiling. 3. Study of the synthetic routes of ecstasy samples within the UK with the aid of route-specific authentic impurity compounds synthesised in-house.
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Graben, Roger Dale Parsons Daniel L. "Promethazine orally disintegrating tablet." Auburn, Ala., 2006. http://hdl.handle.net/10415/1317.

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Murty, Aruna Mummini. "Evaluation of potential multi-particulate drug delivery systems /." View online ; access limited to URI, 2006. http://0-wwwlib.umi.com.helin.uri.edu/dissertations/dlnow/3225324.

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Olsson, Helena. "Particle interactions and internal tablet structure : factors affecting the mechanical strength of pharmaceutical compacts /." Uppsala, Sweden : Uppsala University : Distributed by Uppsala University Library, 2000. http://w3.ub.uu.se/diss/eng/abstract.cfm?ISBN=91-554-4725-2.

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Verner, Jennifer Joan. "Formulation and dissolution assessment of a novel repeat action tablet containing a decongestant and an antihistamine." Thesis, Rhodes University, 2001. http://hdl.handle.net/10962/d1003276.

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Controlled and sustained release dosage forms are the focus of worldwide research. These dosage forms facilitate patient compliance by simplifying the dosage regimen, and decrease the risk of adverse effects by reducing large fluctuations in the plasma concentration of the drug. The objective of this study was to formulate a repeat-action tablet to provide a sustained release dose of pseudoephedrine sulfate (PSS), and an immediate release dose of both PSS and loratadine. The release profile was compared to that of a commercially available preparation, Clarityne-D®. This formulation developed presents a novel mechanism of sustaining the release of PSS. The prototype tablet consisted of a sustained release core coated with an ethylcellulose dispersion to introduce a lag phase into the release profile and a second outer film coat incorporating PSS and loratadine. The core comprised an ethylcellulose granulation of PSS compressed into a hydroxypropyl methylcellulose matrix. The release of PSS from prototypes was assessed using USP Apparatus 3, as this apparatus was more representative of in vivo conditions and discriminated more effectively between the different tablet compositions produced during development. All dissolution samples were analysed for PSS and loratadine using validated highperformance liquid chromatographic methods. The prototype sustained release cores were found to be more resistant than the reference product to elevated temperature and humidity (40°C/87% RH) with fewer observed changes to the release profiles following storage for up to six months. This study was a feasibility study to obtain proof of concept. The release profile obtained from the prototype tablets was similar (f₂ = 50.0) to that of the reference product. Further development and optimisation of this dosage form is necessary, including evaluation of the choice of hydrophobic polymer, the effect of compression force and tablet geometry and characterisation of the release mechanism from the coated matrix. Assessment of these factors is necessary in order to optimise the formulation with respect to the desired therapeutic objectives.
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Khamanga, Sandile Maswazi Malungelo. "Formulation and assessment of verapamil sustained release tablets." Thesis, Rhodes University, 2005. http://hdl.handle.net/10962/d1018236.

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The oral route of drug administration is most extensively used due to the obvious ease of administration. Verapamil hydrochloride is a WHO listed phenylalkylarnine, L-type calcium channel antagonist that is mainly indicated for cardiovascular disorders such as angina pectoris, supraventricular tachycardia and hypertension. Due to its relatively short half-life of approximately 4.0 hours, the formulation of a sustained-release dosage form is useful to improve patient compliance and to achieve predictable and optimized therapeutic plasma concentrations. Direct compression and wet granulation were initially used as methods for tablet manufacture. The direct compression method of manufacture produced tablets that exhibited formulation and manufacturing difficulties. Mini-tablets containing veraparnil hydrochloride were then prepared by wet granulation using Surelease® E-7-19010.and Eudragit® NE 30D as the granulating agents after which the granules were incorporated with an hydrophilic matrix material, Carbopol® 974P NF. Granule and powder blends were evaluated using the angle of repose, loose and tapped bulk density, Can's compressibility index, Hausner's ratio and drug content. Granules with good flow properties and satisfactory compressibility were used for further studies. Tablets were subjected to thickness, diameter and weight variation tests, crushing strength, tensile strength, friability and content uniformity studies. Tablets that showed acceptable pharmaco-technical properties were selected for further analysis. Drug content uniformity and dissolution release rates were determined using a validated isocratic HPLC method. Initially, USP apparatus 1 and 3 dissolution apparatus were used to determine in-vitro drug release rates from the formulations over a 22-hour period. USP apparatus 3 was finally selected as it offers the advantages of mimicking, in part, the changes in the physicochemical environment experienced by products in the gastro-intestinal tract. Differences in release rates between the test formulations and a commercially available product, Isoptin® SR were observed at different pH's using USP apparatus 1. The release of veraparnil hydrochloride from matrix tablets was pH dependent and was markedly reduced at higher pH values. This may be due, in part, to the poor solubility of veraparnil hydrochloride at these pH values and also the possible interaction of verapamil hydrochloride with anionic polymers used in these formulations. Swelling and erosion behaviour of the tablets were evaluated and differences in behaviour were observed which may be attributed to the physico-chemical characteristics of the polymers used in this study. In-vitro dissolution profiles were characterized by the difference (j1) and similarity factor (j2) and also by a new similarity factor, Sct. In addition, the mechanism of drug release from these dosage forms was mainly evaluated using the Korsmeyer-Peppas model and the kinetics of drug release assessed using other models, including Zero order, First order, Higuchi, HixsonCrowell, Weibull and the Baker-Lonsdale model. Dissolution kinetics were best described by application of the Weibull model, and the Korsmeyer-Peppas model. The release exponent, n, confirmed that drug release from these dosage forms was due to the mixed effects of diffusion and swelling and therefore, anomalous release kinetics are predominant. In conclusion, two test batches were found to be comparable to the reference product Isoptin® SR with respect to their in-vitro release profiles.
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Vander, Werf Karie. "Pharmacokinetics and pharmacodynamics of oral meloxicam tablets in healthy horses." Thesis, Kansas State University, 2013. http://hdl.handle.net/2097/15314.

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Master of Science
Department of Clinical Sciences
Elizabeth Davis
The first aim of the current study was to investigate the pharmacokinetics of oral meloxicam tablets and the gastrointestinal and renal effects after a 14-day treatment period. Meloxicam was orally administered to six adult horses once daily at a dosage of 0.6 mg/kg for 14 consecutive days. Blood was collected prior to each administration and at 20 and 40 min, and 1, 2, 4, 8, 12, and 24 hours after administration on days 1, 7, and 14 for the determination of meloxicam plasma concentrations by mass spectrometry. In addition, trough samples were taken on days 3 and 10. Complete blood count, serum biochemical analysis, urinalysis, and gastroscopy were performed at baseline and conclusion of the investigation. Complete blood count, serum chemistry, and urinalysis results were unchanged through the study period. Gastroscopy scores were not significantly increased. The Cmax was 1.82 ± 0.80 µg/mL at Tmax 3.48 ± 3.30 hr on day 1, 2.07 ± 0.94 µg/mL at Tmax 1.24 ± 1.24 hr on day 7, and 1.81 ± 0.76 µg/mL at 1.93 ± 1.30 h on day 14 (p = 0.30). The mean half-life was 4.99 ± 1.11 h. The second aim of the study was to compare the analgesic effects and gastrointestinal and renal adverse effects of oral meloxicam tablets (0.6 mg/kg) to oral phenylbutazone tablets (4.4 mg/kg) orally once daily for 4 days in induced and naturally occurring lameness in adult horses. The study was performed on 4 healthy but lame adult horses. Complete blood count, serum biochemistry, urinalysis, and gastroscopy were performed prior to entrance to the study. Lameness was exacerbated in two horses using lipopolysaccharide (LPS; E. coli O55:B5) injected into the right metacarpophalangeal joint. The remaining two horses had Grade 3 or Grade 4 lameness due to naturally occurring laminitis. Meloxicam or phenylbutazone was administered to two horses each in a blinded, randomized manner once daily for four days. Lameness was evaluated using a pressure mat system and contact pressure, force, and stride length were evaluated at baseline and twice daily. Complete blood count, serum chemistry, and urinalysis were unremarkable for all four horses except one horse with an increased GGT. This horse experienced hepatic rupture secondary to amyloidosis the final day of the study. Gastric ulcer scores did not change during the study period. Phenylbutazone administration resulted in a greater response (force and contact area) in the right front and left hind limbs compared to meloxicam administration. There were not enough data points to evaluate the other two limbs. A third aim of the study was two-fold and first evaluated the effects of ex vivo stimulation of peripheral blood mononuclear cells (PBMCs) with LPS on cyclooxygenase (COX) messenger RNA (mRNA) expression. The second portion documented the effects of LPS-induced joint inflammation and treatment with non-steroidal anti-inflammatory drugs on the mRNA and protein expression of COX-2 in PBMCs. The results indicate that LPS upregulates COX-2 gene expression in PBMCs. Additionally, injection of LPS into the metacarpophalangeal joint increases both COX-2 mRNA and protein expression in PBMCs at 24 hours after injection. The relative expression of COX-2 after treatment with meloxicam or phenylbutazone indicates a stronger inhibition with phenylbutazone; however, further study with additional horses is needed. Pharmacokinetic analysis of the oral tablet formulation of meloxicam indicates the pharmacokinetics are similar to the oral suspension formulation. Meloxicam appears to be inferior to phenylbutazone in its analgesic properties for induced lameness and naturally occurring laminitis, however the small sample size used in the study makes interpretation difficult.
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Maclean, Aldritt Allister. "Comparison of two granulation processes with the view to reduce manufacturing cost." Thesis, Port Elizabeth Technikon, 2004. http://hdl.handle.net/10948/210.

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Aspen Pharmacare, one of the leading pharmaceutical manufacturers in South Africa has embarked on a programme of improving the production processes currently employed at their Port Elizabeth site. With the introduction of new technology at the site and the move towards globalization, it became imperative that Aspen remain competitive in the market. The product of interest in this research, Degoran Plus tablets, is one of the company’s leading brand sellers. Upon investigation, it became apparent that this product created opportunity for process improvement using the new technology. The manufacture of Degoran Plus entails granulation, compression and coating of the product. Most opportunity for improvement was possible in the granulation stage because of the laborious nature of the present process. Degoran Plus tablets had a history of analytical failures, especially with regard to the dissolution rate of the final product, as well as other quality related issues. The product was not considered to be a “through-runner”, which resulted in bad production output, due to continual repeats of not only analysis but also reworks in production. A strategic decision was taken to manufacture Degoran Plus using the Collette Gral granulator as the equipment offered superior mixing capability when compared to the Bear planetary granulator. It was assumed that the granulation process would result in more uniform distribution of the actives. Upon producing a better granule, a final product of superior quality would be attained. The validation protocol stipulates that three samples be taken and tested from the powder mix. Nine samples taken from granulated bulk are treated in the same manner. The validation protocol further stipulates that the first three batches manufactured utilise the new process, and tested according to the protocol. The results obtained from the analysis are evaluated statistically and a conclusion and recommendation were derived based on the evaluation.
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Patel, Fathima. "The development and assessment of a generic carbamazepine sustained release dosage form." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1339/.

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Chillas, Stephanie M. "The Formulation and Evaluation of Orally Disintegrating Tablets: Diphenhydramine HCl." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1371774622.

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Books on the topic "Tablets (Medicine)"

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Einav, Shmuel, 1942 - , author and Friendland Linda 1964 author, eds. Take two tablets: Medicine from the Bible. Amherst, Massachusetts: White River Press, 2016.

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Association, World's Dispensary Medical. Doctor Pierce's anuric tablets for rheumatism, kidneys and backache ... [Bridgeburg, Ont.?: World's Dispensary Medical Association, 1996.

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American Pharmaceutical Association. Tableting Specification Steering Committee. Tableting specification manual: Previously referred to as the IPT standard specifications for tableting tools. 4th ed. Washington, DC: American Pharmaceutical Assoc., 1995.

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1956-, Alderborn Göran, and Nyström Christer 1951-, eds. Pharmaceutical powder compaction technology. New York: Marcel Dekker, 1996.

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Association, American Pharmaceutical. Tableting specification manual: IPT standard specifications for tableting tools. 3rd ed. Washington, D.C: The Association, 1990.

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1944-, Rubinstein M. H., and Pharmaceutical Technology Conference (5th : 1986 : Harrogate, England), eds. Pharmaceutical technology--tableting technology. Chichester, West Sussex, England: Ellis Horwood, 1987.

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Trabich, Gene. Mesopotamian medicine and magic: Studies in honor of Markham J. Geller. Leiden: Brill, 2018.

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American Pharmaceutical Association. Tableting Specification Steering Committee., ed. Tableting specification manual. 5th ed. Washington, DC: American Pharmaceutical Association, 2000.

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Thomas, Nathan. CDDR basic identification guide book. Ozark, MO: Counter Drug Diversion Resource, 2003.

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Association, American Pharmacists, ed. Tableting specification manual. 7th ed. Washington, DC: American Pharmacists Association, 2006.

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Book chapters on the topic "Tablets (Medicine)"

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Nundy, Samiran, Atul Kakar, and Zulfiqar A. Bhutta. "E-Learning in the Developing World." In How to Practice Academic Medicine and Publish from Developing Countries?, 379–91. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-5248-6_40.

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AbstractMedicine is a changing field and so is the art of teaching medicine. To cope up with technology and science is a major challenge. We all have been trained by conventional classroom teaching, which includes seminars, demonstrations, and bedside clinics but should now be aware of e-learning, blended learning, use of smartphones and tablets, webinars, telemedicine, and tele-education. There is lots of medical content in social media (Facebook, Twitter, and LinkedIn), which is very easy to access. This chapter gives an overview of how electronics have changed the way we practice, keep our records, learn, and teach.
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Nève, J., S. Chamart, S. Van Erum, F. Vertongen, and M. Dramaix. "SELENIUM STATUS IN HUMANS AS INVESTIGATED BY THE EFFECTS OF SUPPLEMENTATION WITH Se-ENRICHED YEAST TABLETS." In Selenium in Medicine and Biology, edited by Jean Nève and Alain Favier, 315–20. Berlin, Boston: De Gruyter, 1988. http://dx.doi.org/10.1515/9783110861990-054.

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Polli, James E. "in Vitro-in Vivo Relationships of Several “Immediate” Release Tablets Containing a Low Permeability Drug." In Advances in Experimental Medicine and Biology, 191–98. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4684-6036-0_17.

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Van Erum, S., P. Capel, F. Vertongen, and J. Nève. "EFFECTS OF SELENIUM SUPPLEMENTATION WITH Se ENRICHED YEAST TABLETS ON HEPATIC, MUSCULAR, RENAL AND HEMATOLOGICAL PARAMETERS IN HUMANS." In Selenium in Medicine and Biology, edited by Jean Nève and Alain Favier, 321–24. Berlin, Boston: De Gruyter, 1988. http://dx.doi.org/10.1515/9783110861990-055.

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Palumbo, R., B. Palumbo, L. Cardinali, S. Bonaca, J. Hartwig, and C. Rastelli. "Pharmacoscintigraphic Study of Localization in the G.I. Tract of Controlled Release Tablets Using 153Sm as Marker." In Radioactive Isotopes in Clinical Medicine and Research XXIII, 117–22. Basel: Birkhäuser Basel, 1999. http://dx.doi.org/10.1007/978-3-0348-8782-3_17.

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Hol, W. G. J., and C. L. M. J. Verlinde. "Macromolecular crystallography and medicine." In International Tables for Crystallography, 10–25. Chester, England: International Union of Crystallography, 2006. http://dx.doi.org/10.1107/97809553602060000656.

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Hol, W. G. J., and C. L. M. J. Verlinde. "Macromolecular crystallography and medicine." In International Tables for Crystallography, 13–38. Chester, England: International Union of Crystallography, 2012. http://dx.doi.org/10.1107/97809553602060000806.

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Nahler, Gerhard. "tablet." In Dictionary of Pharmaceutical Medicine, 181. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-89836-9_1381.

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Nahler, Gerhard. "tablet excipients." In Dictionary of Pharmaceutical Medicine, 181. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-89836-9_1382.

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Rusoke-Dierich, Olaf. "Conversion Tables for Physical Units." In Diving Medicine, 93–94. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-73836-9_14.

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Conference papers on the topic "Tablets (Medicine)"

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Zanetti, T. C., T. A. Catelani, E. R. Pereira-Filho, and J. S. Cabral. "LIBS Use in Study of Homogenization and Plasma Characterization in Medicine Tablets." In Latin America Optics and Photonics Conference. Washington, D.C.: OSA, 2018. http://dx.doi.org/10.1364/laop.2018.tu4a.28.

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Tao, Weiye, and Brook Xiao. "Mechanism of Chinese Medicine Hedan Tablets on Anti-hyperlipidemia by Molecular Simulation Study." In 2021 International Conference on Public Health and Data Science (ICPHDS). IEEE, 2021. http://dx.doi.org/10.1109/icphds53608.2021.00046.

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Rusanova, Tatiana Y., Nataliya Shestopalova, Yuliya Fomina, Nataliya Burmistrova, and Dmitriy Silaev. "Quality control of tablets "Papazol" by spectrophotometry using chemometrics." In Saratov Fall Meeting 2020: Optical and Nano-Technologies for Biology and Medicine, edited by Valery V. Tuchin and Elina A. Genina. SPIE, 2021. http://dx.doi.org/10.1117/12.2590713.

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Draman, Wan Nur A'tiqah Wan, Norzila Bukhari, Muhammad Ikman Ishak Ras, Izzati Ismail, and N. M. Lailina. "Design and development of separation tool for tablets and capsules medicine from aluminum pack." In ADVANCES IN MATERIAL SCIENCE AND MANUFACTURING ENGINEERING. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0134943.

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Li, Xu, Yanbing Bai, Yuanfeng Guo, Zining Wang, Yulei Shi, Jian Zuo, and Cunlin Zhang. "Study on terahertz spectra of traditional Chinese medicine tablets with porous and non-porous structures." In Infrared, Millimeter-Wave, and Terahertz Technologies IX, edited by Xi-Cheng Zhang, Masahiko Tani, and Cunlin Zhang. SPIE, 2022. http://dx.doi.org/10.1117/12.2643845.

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Biller, S., J. Domey, P. Fiedler, R. Holzhey, H. Richert, and J. Haueisen. "Dissolution of magnetically marked tablets: Investigations in a physical phantom." In 2012 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2012. http://dx.doi.org/10.1109/embc.2012.6346367.

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Yu, Chu-Qin, Ying-Ying Sun, Zhi-Jian Ma, Yuan-Ping Wang, Zhong-Feng Shi, and Wei-Sheng Zhang. "Content Determination of Notoginsenoside R1, Ginsenoside Rg1 and Ginsenoside Rb1 in Panax Notoginseng Tablets by UPLC." In 2015 International Conference on Medicine and Biopharmaceutical. WORLD SCIENTIFIC, 2016. http://dx.doi.org/10.1142/9789814719810_0134.

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Cui, Xiangzhen. "Design of Intelligent Near Infrared Spectroscopy Monitoring in the Production Process of Traditional Chinese Medicine Tablets." In Proceedings of the 2nd International Conference on Public Management, Digital Economy and Internet Technology, ICPDI 2023, September 1–3, 2023, Chongqing, China. EAI, 2023. http://dx.doi.org/10.4108/eai.1-9-2023.2338798.

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Wada, Yoshio, Yoshiharu Urata, Hiroshi Ito, and Yasuhiro Higashi. "Direct Spectroscopic Imaging of Medicine Tablets using Monochromatic Tunable Terahertz-wave Source and Highly Sensitive Semiconductor Detector." In 2020 45th International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz). IEEE, 2020. http://dx.doi.org/10.1109/irmmw-thz46771.2020.9370554.

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Mohara, Mizuki, Kei Shimura, Kenji Aiko, and Kodo Kawase. "Terahertz spectroscopy using an injection-seeded terahertz parametric generator for quantitative analysis and inspection of over-the-counter medicine tablets." In Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications XI, edited by Laurence P. Sadwick and Tianxin Yang. SPIE, 2018. http://dx.doi.org/10.1117/12.2288029.

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Reports on the topic "Tablets (Medicine)"

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Xu, Guiqin, Mingxin Lin, and Xueli Dai. Efficacy and safety of Danlou tablets combined with western medicine for patients undergoing PCI : a protocol for systematic review and meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2021. http://dx.doi.org/10.37766/inplasy2021.1.0023.

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Xu, Guiqin, Mingxin Lin, and Xueli Dai. Efficacy and safety of Danlou tablets combined with western medicine for patients undergoing PCI : a protocol for systematic review and meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2021. http://dx.doi.org/10.37766/inplasy2021.1.0023.

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Tang, Jiqin, Gong Zhang, Jinxiao Xing, Ying Yu, and Tao Han. Network Meta-analysis of Heat-clearing and Detoxifying Oral Liquid of Chinese Medicines in Treatment of Children’s Hand-foot-mouth Disease：a protocol for systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2022. http://dx.doi.org/10.37766/inplasy2022.1.0032.

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Review question / Objective: The type of study was clinical randomized controlled trial (RCT). The object of study is the patients with HFMD. There is no limit to gender and race. In the case of clear diagnosis standard, curative effect judgment standard and consistent baseline treatment, the experimental group was treated with pure oral liquid of traditional Chinese medicine(A: Fuganlin oral liquid, B: huangzhihua oral liquid, C: Lanqin oral liquid, D: antiviral oral liquid, E: Huangqin oral liquid, F: Pudilan oral liquid, G: Shuanghuanglian oral liquid.)and the control group was treated with ribavirin or any oral liquid of traditional Chinese medicine. The data were extracted by two researchers independently, cross checked and reviewed according to the pre-determined tables. The data extraction content is (1) Basic information (including the first author, published journal and year, research topic). (2) Relevant information (including number of cases, total number of cases, gender, age, intervention measures, course of treatment of the experimental group and the control group in the literature). (3) Design type and quality evaluation information of the included literature. (4) Outcome measures (effective rate, healing time of oral ulcer, regression time of hand and foot rash, regression time of fever, adverse reactions.). The seven traditional Chinese medicine oral liquids are comparable in clinical practice, but their actual clinical efficacy is lack of evidence-based basis. Therefore, the purpose of this study is to use the network meta-analysis method to integrate the clinical relevant evidence of direct and indirect comparative relationship, to make quantitative comprehensive statistical analysis and sequencing of different oral liquid of traditional Chinese medicine with the same evidence body for the treatment of the disease, and then to explore the advantages and disadvantages of the efficacy and safety of different oral liquid of traditional Chinese medicine to get the best treatment plan, so as to provide reference value and evidence-based medicine evidence for clinical optimization of drug selection. Condition being studied: Hand foot mouth disease (HFMD) is a common infectious disease in pediatrics caused by a variety of enteroviruses. Its clinical manifestations are mainly characterized by persistent fever, hand foot rash, oral herpes, ulcers, etc. Because it is often found in preschool children, its immune system development is not perfect, so it is very vulnerable to infection by pathogens and epidemic diseases, resulting in rapid progress of the disease. A few patients will also have neurogenic pulmonary edema Meningitis, myocarditis and other serious complications even lead to death, so effectively improve the cure rate, shorten the course of disease, prevent the deterioration of the disease as the focus of the study. In recent years, traditional Chinese medicine has played an important role in the research of antiviral treatment. Many clinical practices have confirmed that oral liquid of traditional Chinese medicine can effectively play the role of antiviral and improve the body's immunity.
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Seidametova, Zarema S., Zinnur S. Abduramanov, and Girey S. Seydametov. Using augmented reality for architecture artifacts visualizations. [б. в.], July 2021. http://dx.doi.org/10.31812/123456789/4626.

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Nowadays one of the most popular trends in software development is Augmented Reality (AR). AR applications offer an interactive user experience and engagement through a real-world environment. AR application areas include archaeology, architecture, business, entertainment, medicine, education and etc. In the paper we compared the main SDKs for the development of a marker-based AR apps and 3D modeling freeware computer programs used for developing 3D-objects. We presented a concept, design and development of AR application “Art-Heritage’’ with historical monuments and buildings of Crimean Tatars architecture (XIII-XX centuries). It uses a smartphone or tablet to alter the existing picture, via an app. Using “Art-Heritage’’ users stand in front of an area where the monuments used to be and hold up mobile device in order to see an altered version of reality.
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Gindi, Renee. Health, United States, 2019. Centers for Disease Control and Prevention (U.S.), 2021. http://dx.doi.org/10.15620/cdc:100685.

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Health, United States, 2019 is the 43rd report on the health status of the nation and is submitted by the Secretary of the Department of Health and Human Services to the President and the Congress of the United States in compliance with Section 308 of the Public Health Service Act. This report was compiled by the National Center for Health Statistics (NCHS) of the Centers for Disease Control and Prevention (CDC). The Health, United States series presents an annual overview of national trends in key health indicators. The 2019 report presents trends and current information on selected measures of morbidity, mortality, health care utilization and access, health risk factors, prevention, health insurance, and personal health care expenditures in a 20-figure chartbook. The Health, United States, 2019 Chartbook is supplemented by several other products including Trend Tables, an At-a-Glance table, and Appendixes available for download on the Health, United States website at: https://www.cdc.gov/nchs/hus/ index.htm. The Health, United States, 2019 Chartbook contains 20 figures and 20 tables on health and health care in the United States. Examining trends in health informs the development, implementation, and evaluation of health policies and programs. The first section (Figures 1–13) focuses on health status and determinants: life expectancy, infant mortality, selected causes of death, overdose deaths, suicide, maternal mortality, teen births, preterm births, use of tobacco products, asthma, hypertension, heart disease and cancer, and functional limitations. The second section (Figures 14–15) presents trends in health care utilization: use of mammography and colorectal tests and unmet medical needs. The third section (Figures 16–17) focuses on health care resources: availability of physicians and dentists. The fourth section (Figures 18–20) describes trends in personal health care expenditures, health insurance coverage, and supplemental insurance coverage among Medicare beneficiaries. The Highlights section summarizes major findings from the Chartbook. Suggested citation: National Center for Health Statistics. Health, United States, 2019. Hyattsville, MD. 2021.
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Guzman Paredes, Yomaira. Realidad aumentada utilizando Unity. Ediciones Universidad Cooperativa de Colombia, December 2022. http://dx.doi.org/10.16925/gcgp.64.

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La realidad aumentada nos permite añadir capas de información visual sobre el mundo real, mediante el uso de tecnologías, dispositivos móviles y tabletas inteligentes. El propósito de esta guía práctica es desarrollar las competencias en el uso y la aplicación de la realidad aumentada en distintos escenarios. Esta guía práctica describe cómo crear un proyecto de realidad aumentada en Unity y cómo crear los marcadores a través de Vuforia. La realidad aumentada tiene diferentes aplicaciones en variadas áreas como en educación, turismo, entretenimiento, logística empresarial, diseño, medicina, entre muchas otras. En esta oportunidad, su aplicación está enfocada al entretenimiento, utilizando el juego de la baraja española para explicar sus características, mediante el uso del motor de Unity por medio del cual es posible reproducir un objeto en 3D. Para su funcionamiento, se relaciona con la plataforma de Vuforia. Esta guía práctica lleva a la persona interesada paso a paso en el desarrollo del ejercicio, iniciando con recomendaciones técnicas, conceptualización de las plataformas por utilizar y el desarrollo paso a paso de la actividad. Una vez haya finalizado esta guía, el estudiante estará en capacidad de desarrollar proyectos básicos que incorporen la realidad aumentada mediante el uso de Unity y Vuforia.
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A, Bengolea, Chamorro F, Catalano HN, and Izcovich A. Assessing the safety and effectiveness of the bivalent vaccine against respiratory syncytial virus in pregnant women: a systematic review. Epistemonikos Interactive Evidence Synthesis, April 2024. http://dx.doi.org/10.30846/ies.ac54af0724.

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Objective The aim of this systematic review is to conduct a comprehensive assessment of the efficacy and safety of the bivalent vaccine against the respiratory syncytial virus (RSV) compared to the placebo or the absence of vaccination in pregnant women to inform a clinical recommendation at the internal medicine department of Hospital Alemán of Buenos Aires. Methods In order to identify randomized clinical trials that evaluate our question of interest, we carry out thorough searches in Epistemonikos and Pubmed, from the date of creation of each source until January of the year 2024. Additionally, we consider additional sources to identify referencias that could not have been identified through electronic search. Two reviewers independently selected the studies included, extracted data and evaluated the risk of bias. We perform a quantitative synthesis (meta-analysis) and prepare summary tables of findings as recommended by the Grade Group. The results of this review were presented to a team of clinical experts of the internal medicine department of Hospital Alemán of Buenos Aires who analyzed and issued judgments for each of the criteria proposed within the framework of evidence to the decision. After issuing the judgments for each criterion, experts formulated the clinical recommendation for the problem of interest. Result Through the search strategy, 331 references were identified that were examined by title and summary. Of these, 14 references for the evaluation by full text were included. Finally, 2 randomized clinical trials were included. The bivalent vaccine against RSV in pregnant women probably decreases the risk of respiratory infection, severe respiratory infection and hospitalization by RSV in the newborn. The bivalent vaccine against RSV in pregnant women probably does not increase the risk of presenting serious adverse events in the mother and does not generate an increase in non -serious adverse events (both in the mother and in the newborn). The bivalent vaccine against RSV in pregnant women could generate a slight increase in serious adverse events in the newborn (13 more events for 1,000 newborns), however the certainty of evidence is low. Clinical recommendation Based on this body of evidence, the German Hospital of Buenos Aires conditionally recommends the use of the bivalent vaccine for RSV in pregnant patients (32 to 36 weeks of gestation) (CONDITIONAL RECOMMENDATION IN FAVOR, LOW CERTAINTY IN THE EVIDENCE). Conclusions The bivalent vaccine against RSV in pregnant women presents significant benefits by reducing the risk of severe respiratory infections in newborns, supported by overall safety in pregnant women.
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A, Bengolea, Chamorro F, Catalano HN, and Izcovich A. Assessing the safety and effectiveness of the bivalent vaccine against respiratory syncytial virus in pregnant women: a systematic review. Epistemonikos Interactive Evidence Synthesis, January 2024. http://dx.doi.org/10.30846/ies.ac54af0724.v1.

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Objective The aim of this systematic review is to conduct a comprehensive assessment of the efficacy and safety of the bivalent vaccine against the respiratory syncytial virus (RSV) compared to the placebo or the absence of vaccination in pregnant women to inform a clinical recommendation at the internal medicine department of Hospital Alemán of Buenos Aires. Methods In order to identify randomized clinical trials that evaluate our question of interest, we carry out thorough searches in Epistemonikos and Pubmed, from the date of creation of each source until January of the year 2024. Additionally, we consider additional sources to identify referencias that could not have been identified through electronic search. Two reviewers independently selected the studies included, extracted data and evaluated the risk of bias. We perform a quantitative synthesis (meta-analysis) and prepare summary tables of findings as recommended by the Grade Group. The results of this review were presented to a team of clinical experts of the internal medicine department of Hospital Alemán of Buenos Aires who analyzed and issued judgments for each of the criteria proposed within the framework of evidence to the decision. After issuing the judgments for each criterion, experts formulated the clinical recommendation for the problem of interest. Result Through the search strategy, 331 references were identified that were examined by title and summary. Of these, 14 references for the evaluation by full text were included. Finally, 2 randomized clinical trials were included. The bivalent vaccine against RSV in pregnant women probably decreases the risk of respiratory infection, severe respiratory infection and hospitalization by RSV in the newborn. The bivalent vaccine against RSV in pregnant women probably does not increase the risk of presenting serious adverse events in the mother and does not generate an increase in non -serious adverse events (both in the mother and in the newborn). The bivalent vaccine against RSV in pregnant women could generate a slight increase in serious adverse events in the newborn (13 more events for 1,000 newborns), however the certainty of evidence is low. Clinical recommendation Based on this body of evidence, the German Hospital of Buenos Aires conditionally recommends the use of the bivalent vaccine for RSV in pregnant patients (32 to 36 weeks of gestation) (CONDITIONAL RECOMMENDATION IN FAVOR, LOW CERTAINTY IN THE EVIDENCE). Conclusions The bivalent vaccine against RSV in pregnant women presents significant benefits by reducing the risk of severe respiratory infections in newborns, supported by overall safety in pregnant women.
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