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Journal articles on the topic 'T cell transfer'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Sharma, Preeti, and David M. Kranz. "T Cell Receptors for Gene Transfer in Adoptive T Cell Therapy." Critical Reviews in Immunology 39, no. 2 (2019): 105–22. http://dx.doi.org/10.1615/critrevimmunol.2019030788.

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2

Berger, Carolina, Michael C. Jensen, and Stanley R. Riddell. "Establishing T Cell Memory by Adoptive Transfer of T Cell Clones." Blood 108, no. 11 (2006): 866. http://dx.doi.org/10.1182/blood.v108.11.866.866.

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Abstract Adoptive transfer of T cells has been employed to reconstitute T cell immunity to viruses such as cytomegalovirus (CMV) in immunodeficient allogeneic stem cell transplant (SCT) patients and is being investigated to treat malignancies. In the allogeneic SCT setting, the T cells are derived from the donor and need to be isolated as clones or highly pure populations to avoid graft-versus-host disease. CD8+ T cells can be divided into defined subsets including CD62L− effector memory (TEM) and central memory T cells (TCM) expressing the CD62L lymph node homing molecule. Both TCM and TEM ca

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3

Itzhaki, Orit, Daphna Levy, Dragoslav Zikich, et al. "Adoptive T-cell transfer in melanoma." Immunotherapy 5, no. 1 (2013): 79–90. http://dx.doi.org/10.2217/imt.12.143.

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4

Kessels, Helmut W. H. G., Monika C. Wolkers, and Ton N. M. Schumacher. "Adoptive transfer of T-cell immunity." Trends in Immunology 23, no. 5 (2002): 264–69. http://dx.doi.org/10.1016/s1471-4906(02)02219-6.

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5

Chakrabarti, Indranil. "T-cell transfer therapy: A primer." IP Journal of Diagnostic Pathology and Oncology 8, no. 3 (2023): 127–29. http://dx.doi.org/10.18231/j.jdpo.2023.030.

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6

Conrad, Heinke, Peter Meyerhuber, Barbara Kast, et al. "Redirection of human T lymphocytes towards HER2 by T cell receptor gene transfer for adoptive T cell transfer (41.6)." Journal of Immunology 182, no. 1_Supplement (2009): 41.6. http://dx.doi.org/10.4049/jimmunol.182.supp.41.6.

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Abstract The clinical goal of our studies is the adoptive transfer of primary T cells transduced with a HER2-specific T cell receptor (TCR) for patients with HER2-overexpressing breast cancer. HLA-A2-, CD8 T cells were stimulated with allogeneic HLA-A2+ dendritic cells (DC) pulsed with the peptide HER2369-377. HER2369-377-reactive T cells were screened, cloned and further tested in functional assays. The TCR from the HER2-reactive CTL clone KU1 was cloned into a retrovirus. Primary T lymphocytes were transduced with this construct and functionally compared with the parental CTL clone KU1. The

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7

Chapman, Paul B. "Programming T cells for adoptive T cell transfer therapy." Pigment Cell & Melanoma Research 23, no. 2 (2010): 155–56. http://dx.doi.org/10.1111/j.1755-148x.2010.00681.x.

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8

Isser, Ariel, and Jonathan P. Schneck. "High-affinity T cell receptors for adoptive cell transfer." Journal of Clinical Investigation 129, no. 1 (2018): 69–71. http://dx.doi.org/10.1172/jci125471.

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9

Han, Fei, Emilia R. Dellacecca, Levi W. Barse, et al. "Adoptive T-Cell Transfer to Treat Lymphangioleiomyomatosis." American Journal of Respiratory Cell and Molecular Biology 62, no. 6 (2020): 793–804. http://dx.doi.org/10.1165/rcmb.2019-0117oc.

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10

Tey, Siok‐Keen, Catherine M. Bollard, and Helen E. Heslop. "Adoptive T‐cell transfer in cancer immunotherapy." Immunology & Cell Biology 84, no. 3 (2006): 281–89. http://dx.doi.org/10.1111/j.1440-1711.2006.01441.x.

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11

Alderton, Gemma K. "Promising results from autologous T cell transfer." Nature Reviews Cancer 14, no. 4 (2014): 215. http://dx.doi.org/10.1038/nrc3716.

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12

Jensen, Michael C. "Engineering GVL Through T Cell Gene Transfer." Biology of Blood and Marrow Transplantation 14, no. 1 (2008): 5. http://dx.doi.org/10.1016/j.bbmt.2007.10.011.

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13

Veatch, Joshua, Kelly Paulson, Yuta Asano, et al. "Merkel polyoma virus specific T-cell receptor transgenic T-cell therapy in PD-1 inhibitor refractory Merkel cell carcinoma." Journal of Clinical Oncology 40, no. 16_suppl (2022): 9549. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.9549.

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9549 Background: Merkel cell carcinoma is an aggressive neuroendocrine tumor of skin origin with most cases caused by the Merkel polyoma virus (MCPyV). While many patients benefit from PD-1/PD-L1 axis blockade, most patients do not respond or develop resistance. We sought to ask whether adoptive transfer of autologous T cells transduced with MCPyV specific T cells could lead to clinical responses in PD-1 inhibitor refractory patients. Methods: Five MCPyV positive, HLA-A02 patients with PD-1 inhibitor refractory metastatic Merkel cell carcinoma were treated with adoptive transfer of CD62L+ CD8+

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14

Ptak, W., D. R. Green, and P. Flood. "Cellular interactions in the adoptive transfer of contact sensitivity: characterization of an antigen-nonspecific Vicia villosa-adherent T cell needed for adoptive transfer into naive recipients." Journal of Immunology 137, no. 6 (1986): 1822–28. http://dx.doi.org/10.4049/jimmunol.137.6.1822.

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Abstract The adoptive transfer of delayed-type hypersensitivity (DTH) into naive recipients requires the interaction of two functionally distinct Ly-1+ T cells: and I-J- cell effector cell for DTH which transfers antigen-specific DTH only into animals whose suppressive mechanisms have been compromised, and and I-J+ cell which alone never transfers DTH but allows the transfer of DTH by the I-J- DTH effector cell into naive animals. We investigated the phenotypic and functional characteristics of the cell which "protects" the I-J- DTH effector cell from host suppressive mechanisms and allows the

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15

Houot, Roch, Liora Michal Schultz, Aurélien Marabelle, and Holbrook Kohrt. "T-cell–based Immunotherapy: Adoptive Cell Transfer and Checkpoint Inhibition." Cancer Immunology Research 3, no. 10 (2015): 1115–22. http://dx.doi.org/10.1158/2326-6066.cir-15-0190.

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16

Zakrzewski, Johannes L., Adam A. Kochman, Sydney X. Lu, et al. "Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation." Nature Medicine 12, no. 9 (2006): 1039–47. http://dx.doi.org/10.1038/nm1463.

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17

Iqbal, Nuzhat, James R. Oliver, Frederic H. Wagner, Audrey J. Lazenby, Charles O. Elson, and Casey T. Weaver. "T Helper 1 and T Helper 2 Cells Are Pathogenic in an Antigen-specific Model of Colitis." Journal of Experimental Medicine 195, no. 1 (2002): 71–84. http://dx.doi.org/10.1084/jem.2001889.

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Dysregulated T cell responses to enteric bacteria have been implicated as a common mechanism underlying pathogenesis in rodent models of colitis. However, the bacterial species and T cell specificities that induce disease have been poorly defined. We have developed a model system in which target antigen, bacterial host, and corresponding T cell specificity are defined. OVA-specific T cells from DO11.RAG-2−/− TCR transgenic mice were transferred into RAG-2−/− recipients whose intestinal tracts were colonized with OVA-expressing or control Escherichia coli. Transfer of antigen-naive DO11.RAG-2−/

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18

Balakrishnan, Amritha, Burhan Jama, and Gerald P. Morris. "Endogenous Secondary TCRs Promote Homeostatic Advantage Via Recognition of Self-Antigens." Journal of Immunology 198, no. 1_Supplement (2017): 215.9. http://dx.doi.org/10.4049/jimmunol.198.supp.215.9.

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Abstract Our laboratory studies how non-thymically selected secondary TCRs contribute to the T cell repertoire. We have previously demonstrated that peripheral T cells naturally expressing 2 TCRs have increased response to autoantigens. We hypothesized that this could promote homeostatic proliferation of T cells expressing 2 TCRs, which may cause autoimmune risk. To examine secondary TCRs in homeostasis, we performed competitive transfers of CFSE-labeled T cells from B6.Ly5.1 and B6.TCRα+/−.Thy1.1 (lacking secondary TCRs) into irradiated B6 recipients. T cells injected at a 1:1 ratio demonstra

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19

Katsura, Y., T. Kina, T. Amagai, et al. "Limiting dilution analysis of the stem cells for T cell lineage." Journal of Immunology 137, no. 8 (1986): 2434–39. http://dx.doi.org/10.4049/jimmunol.137.8.2434.

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Abstract Stem cell activities of bone marrow, spleen, thymus, and fetal liver cells for T cell lineage were studied comparatively by transferring the cells from these organs through i.v. or intrathymus (i.t.) route into right leg- and tail-shielded (L-T-shielded) and 900 R-irradiated recipient mice, which were able to survive without supplying hemopoietic stem cells. Cells from B10.Thy-1.1 (H-2b, Thy-1.1) mice were serially diluted and were transferred into L-T-shielded and irradiated C57BL/6 (H-2b, Thy-1.2) mice, and 21 days later the thymus cells of recipient mice were assayed for Thy-1.1+ c

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20

Hamad, M., M. Whetsell, and J. R. Klein. "T cell precursors in the spleen give rise to complex T cell repertoires in the thymus and the intestine." Journal of Immunology 155, no. 6 (1995): 2866–76. http://dx.doi.org/10.4049/jimmunol.155.6.2866.

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Abstract T cell precursors located in peripheral immune tissues have been studied according to the potential to repopulate the thymus and the gut of lethally irradiated mice. T cell repopulation could be achieved with spleen cells from athymic or euthymic mice thoroughly devoid of mature T cells. Repopulation did not occur with lymph node lymphocytes as determined from studies in congenic mice. The kinetics of T cell repopulation differed in the gut and thymus in that donor-derived T cells appeared in the gut by day 7 after cell transfer, and in the thymus by day 14 after cell transfer. The mu

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21

Romero, Diana. "T cell transfer after allo-HSCT in AML." Nature Reviews Clinical Oncology 16, no. 9 (2019): 528. http://dx.doi.org/10.1038/s41571-019-0251-z.

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22

Maus, Marcela V. "Tumour tamed by transfer of one T cell." Nature 558, no. 7709 (2018): 193–95. http://dx.doi.org/10.1038/d41586-018-05251-5.

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23

EPSTEIN, W., M. OKAMOTO, H. SUYA, and K. FUKUYAMA. "T-cell independent transfer of organized granuloma formation." Immunology Letters 14, no. 1 (1986): 59–63. http://dx.doi.org/10.1016/0165-2478(86)90021-0.

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24

Moss, Paul A. H. "Redirecting T cell specificity by TCR gene transfer." Nature Immunology 2, no. 10 (2001): 900–901. http://dx.doi.org/10.1038/ni1001-900.

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25

de Witte, Moniek A., Miriam Coccoris, Monika C. Wolkers, et al. "Targeting self-antigens through allogeneic TCR gene transfer." Blood 108, no. 3 (2006): 870–77. http://dx.doi.org/10.1182/blood-2005-08-009357.

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Abstract Adoptive transfer of T-cell receptor (TCR) genes has been proposed as an attractive approach for immunotherapy in cases where the endogenous T-cell repertoire is insufficient. While there are promising data demonstrating the capacity of TCR-modified T cells to react to foreign antigen encounter, the feasibility of targeting tumor-associated self-antigens has not been addressed. Here we demonstrate that T-cell receptor gene transfer allows the induction of defined self-antigen–specific T-cell responses, even when the endogenous T-cell repertoire is nonreactive. Furthermore, we show tha

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26

Kamanaka, Masahito, Samuel Huber, Lauren A. Zenewicz, et al. "Memory/effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathology." Journal of Experimental Medicine 208, no. 5 (2011): 1027–40. http://dx.doi.org/10.1084/jem.20102149.

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The role of direct IL-10 signaling in different T cell subsets is not well understood. To address this, we generated transgenic mice expressing a dominant-negative IL-10 receptor specifically in T cells (CD4dnIL-10Rα). We found that Foxp3-depleted CD45RBlo (regulatory T cell [Treg cell]–depleted CD45RBlo) but not CD45RBhi CD4+ T cells are controlled directly by IL-10 upon transfer into Rag1 knockout (KO) mice. Furthermore, the colitis induced by transfer of Treg cell–depleted CD45RBlo CD4+ T cells into Rag1 KO mice was characterized by reduced Th1 and increased Th17 cytokine messenger RNA leve

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27

Sprague, Wendy S., Melissa Robbiani, Paul R. Avery, Kevin P. O'Halloran, and Edward A. Hoover. "Feline immunodeficiency virus dendritic cell infection and transfer." Journal of General Virology 89, no. 3 (2008): 709–15. http://dx.doi.org/10.1099/vir.0.83068-0.

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Feline immunodeficiency virus (FIV) interacts with dendritic cells (DC) during initiation of infection, but whether DC support or transfer FIV infection remains unclear. To address this issue, we studied the susceptibility of feline myeloid DC to FIV infection and assessed potential transfer of infection from DC to CD4+ T cells. FIV was detected in membrane-bound vesicles of DC within 2 h of inoculation, although only low concentrations of FIV DNA were found in virus-exposed isolated DC. Addition of resting CD4+ T cells increased viral DNA levels; however, addition of activated CD4+ T cells re

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28

Autio, Anu, Huan Wang, Francisco Velázquez та ін. "SIRPα - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen". PLOS ONE 17, № 4 (2022): e0266566. http://dx.doi.org/10.1371/journal.pone.0266566.

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The SIRPα-CD47 axis plays an important role in T cell recruitment to sites of immune reaction and inflammation but its role in T cell antigen priming is incompletely understood. Employing OTII TCR transgenic mice bred to Cd47-/- (Cd47KO) or SKI mice, a knock-in transgenic animal expressing non-signaling cytoplasmic-truncated SIRPα, we investigated how the SIRPα-CD47 axis contributes to antigen priming. Here we show that adoptive transfer of Cd47KO or SKI Ova-specific CD4+ T cells (OTII) into Cd47KO and SKI recipients, followed by Ova immunization, elicited reduced T cell division and prolifera

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29

Kitamura, K., J. Farber, and B. Kelsall. "Possible role for CCR6+ regulatory T cell in the T cell-transfer model of colitis." Inflammatory Bowel Diseases 17, suppl_1 (2011): S5. http://dx.doi.org/10.1093/ibd/17.supplement1.s5a.

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30

Karachi, Aida, Farhad Dastmalchi, Ashley O’Malley, Megan Saia, Duane Mitchell, and Maryam Rahman. "IMMU-07. CELLULAR IMMUNOTHERAPY TO OVERCOME TEMOZOLOMIDE INDUCED T CELL EXHAUSTION IN GLIOBLASTOMA." Neuro-Oncology 21, Supplement_6 (2019): vi120. http://dx.doi.org/10.1093/neuonc/noz175.501.

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Abstract INTRODUCTION We have previously demonstrated that standard dose (SD) temozolomide results in T cell exhaustion in glioblastoma. In this study, we hypothesized that cellular immunotherapies will prevent T cell exhaustion. We tested temozolomide treatment with adoptive T cell transfer alone, dendritic cell (DC) vaccines alone and T cell transfer in combination with DC vaccines. METHOD GL-261-gp100 tumor-bearing mice were treated with SD (50 mg/kg for 5 days) or metronomic dose (MD) (25 mg/kg for 10 days) temozolomide. CD3+ T cells were isolated from Pmel mice and infused intravenously.

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31

Heemskerk, Mirjam H. M., Manja Hoogeboom, Renate Hagedoorn, Michel G. D. Kester, Roel Willemze, and J. H. Frederik Falkenburg. "Reprogramming of Virus-specific T Cells into Leukemia-reactive T Cells Using T Cell Receptor Gene Transfer." Journal of Experimental Medicine 199, no. 7 (2004): 885–94. http://dx.doi.org/10.1084/jem.20031110.

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T cells directed against minor histocompatibility antigens (mHags) might be responsible for eradication of hematological malignancies after allogeneic stem cell transplantation. We investigated whether transfer of T cell receptors (TCRs) directed against mHags, exclusively expressed on hematopoietic cells, could redirect virus-specific T cells toward antileukemic reactivity, without the loss of their original specificity. Generation of T cells with dual specificity may lead to survival of these TCR-transferred T cells for prolonged periods of time in vivo due to transactivation of the endogeno

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32

Ku, Manching, Eugene Ke, Mohsen Sabouri-Ghomi, et al. "Deconstructive somatic cell nuclear transfer reveals novel regulatory T-cell subsets." Journal of Allergy and Clinical Immunology 142, no. 3 (2018): 997–1000. http://dx.doi.org/10.1016/j.jaci.2018.04.038.

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33

Neudorfer, Julia, Daniel Sommermeyer, Christian Peschel, Thomas Blankenstein, Wolfgang Uckert, and Helga Bernhard. "Redirecting Human T Lymphocytes toward Tumor-Associated Antigens by T Cell Receptor (TCR) Replacement." Blood 108, no. 11 (2006): 3711. http://dx.doi.org/10.1182/blood.v108.11.3711.3711.

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Abstract The gene transfer of alpha and beta chains derived from a defined TCR has been successfully applied to endow T cells with specificities directed against tumor-associated antigens. However, it is still unclear if the transfer of TCR genes into T cells that already express an endogenous TCRalpha and beta chain leads to engineered T cells expressing four different TCR complexes on their cell surface. Mixed TCR heterodimers composed of endogenous and exogenous TCR chains may acquire new specificities, which may cause unwanted reactions in patients following adoptive T cell transfer. We ex

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34

Cheng, Jie, Guanghua Chen, Hui Lv, et al. "CD4-Targeted T Cells Rapidly Induce Remissions in Mice with T Cell Lymphoma." BioMed Research International 2021 (March 27, 2021): 1–6. http://dx.doi.org/10.1155/2021/6614784.

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Objective. To explore the immune cell therapy for T cell lymphoma, we developed CD4-specific chimeric antigen receptor- (CAR-) engineered T cells (CD4CART), and the cytotoxic effects of CD4CART cells were determined in vitro and in vivo. Methods. CD4CART cells were obtained by transduction of lentiviral vector encoding a single-chain antibody fragment (scFv) specific for CD4 antigen, costimulatory factor CD28 fragment, and intracellular signal transduction domain of CD3 fragments. Control T cells were obtained by transduction of reporter lentiviral vector. The cytotoxicity, tumor growth, and s

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35

Debets, Reno, Ralph Willemsen, and Reinder Bolhuis. "Adoptive transfer of T-cell immunity: gene transfer with MHC-restricted receptors." Trends in Immunology 23, no. 9 (2002): 435–36. http://dx.doi.org/10.1016/s1471-4906(02)02290-1.

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36

Schumacher, Ton N. M., Monika C. Wolkers, and Helmut W. H. G. Kessels. "Adoptive transfer of T-cell immunity: gene transfer with MHC-restricted receptors." Trends in Immunology 23, no. 9 (2002): 436–37. http://dx.doi.org/10.1016/s1471-4906(02)02292-5.

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37

Ostanin, Dmitry V., Kevin P. Pavlick, Sulaiman Bharwani, et al. "T cell-induced inflammation of the small and large intestine in immunodeficient mice." American Journal of Physiology-Gastrointestinal and Liver Physiology 290, no. 1 (2006): G109—G119. http://dx.doi.org/10.1152/ajpgi.00214.2005.

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It is well known that transfer of CD4+CD45RBhigh (naïve) T cells into syngeneic lymphocyte-deficient mice induces chronic colitis. However, no studies have reported the presence of small bowel inflammation in this T cell-dependent model. Therefore, the objective of this study was to evaluate and compare small and large bowel inflammation induced by transfer of naïve T cells into two different immunodeficient recipient mice. T and B cell-deficient recombinase activating gene 1-deficient [RAG knockout (KO)] and T cell-deficient T cell receptor-β × T cell receptor-δ double-deficient (TCR KO) mice

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38

Srivastava, Smita, and Joel D. Ernst. "Cell-to-Cell Transfer of M. tuberculosis Antigens Optimizes CD4 T Cell Priming." Cell Host & Microbe 15, no. 6 (2014): 741–52. http://dx.doi.org/10.1016/j.chom.2014.05.007.

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39

Heslop, Helen E. "Expansion of Lymphocytes for Cell-Based Therapeutics." Blood 116, no. 21 (2010): SCI—48—SCI—48. http://dx.doi.org/10.1182/blood.v116.21.sci-48.sci-48.

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Abstract Abstract SCI-48 Adoptive transfer of T cells can lead to targeted and long-lived anti-tumor or anti-infective activity and can also modulate alloreactivity. T cell therapies have been used in both autologous and allogeneic settings. Donor-derived cytotoxic specific T lymphocytes (CTLs) have already proved highly effective in preventing or treating viral infections and Epstein-Barr virus (EBV) lymphomas developing after allogeneic hemopoietic stem cell transplant while T cells expanded ex vivo with CD3/28 beads have enhanced immune reconstitution after autologous stem cell transplantat

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40

Koste, L., T. Beissert, H. Hoff, L. Pretsch, Ö. Türeci, and U. Sahin. "T-cell receptor transfer into human T cells with ecotropic retroviral vectors." Gene Therapy 21, no. 5 (2014): 533–38. http://dx.doi.org/10.1038/gt.2014.25.

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41

Kageyama, Shinichi, Mikiya Ishihara, Shigehisa Kitano, et al. "Cytokine Release Syndrome and Tumor Responses in a First-in-Man Trial of a Novel Affinity-Enhanced TCR-Gene Transduced T Cell Transfer Targeting NY-ESO-1 Antigen." Blood 130, Suppl_1 (2017): 841. http://dx.doi.org/10.1182/blood.v130.suppl_1.841.841.

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Abstract Adoptive cell transfers of receptor gene-engineered T cells include chimeric antigen receptor-gene transduced T (CAR-T) cell therapy and TCR-gene transduced T (TCR-T) cell therapy. In CD19-CAR-T cell therapy, high incidence of cytokine release syndrome (CRS) is associated with in vivo CAR-T cell proliferation and its clinical efficacy. In human TCR-T cell therapies, there have not been well known about CRS and its association with in vivo T cell kinetics or tumor responses. We have been developing a novel-type affinity-enhanced NY-ESO-1-specific TCR, and an original retrovirus vector

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42

Berger, Carolina, Michael Jensen, and Stanley R. Riddell. "Development of a Nonhuman Primate Model for Analysis of the Adoptive Transfer of Antigen-Specific T Cell Clones." Blood 106, no. 11 (2005): 770. http://dx.doi.org/10.1182/blood.v106.11.770.770.

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Abstract In principle, the adoptive transfer of T cell clones specific for antigens expressed by pathogens or malignant cells could be therapeutically effective and allow precise control of the specificity, function, and magnitude of T cell immunity. However, the infusion of large numbers of cultured T cells or T cell clones in clinical trials has frequently failed to eradicate tumors or provide long-term control of infection. This may be due in part to the acquisition of an effector phenotype by the T cells during in vitro culture, which reduces their ability to survive in vivo and establish

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43

Zhang, Hui, and Alex A. Little. "Double negative T cell-NK cell axis orchestrates antitumor immunity against triple negative breast cancer." Journal of Immunology 210, no. 1_Supplement (2023): 237.04. http://dx.doi.org/10.4049/jimmunol.210.supp.237.04.

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Abstract Triple-negative breast cancer (TNBC) is hard to treat because of the development of chemoresistance and metastasis. It is recently found that the combination of chemotherapy and immune checkpoint blockade can significantly improve TNBC treatment. However, the low response rate to immunotherapy greatly hampers the application of immunotherapy to TNBC. It is urgent to find new paradigms to improve immunotherapy for TNBC. We previously found that transferring thymocytes into Ja281 KO mice could inhibit E0771 TNBC formation. Herein, we further determine the underlying mechanism. We found

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44

Dowhan, William. "Phospholipid-transfer proteins." Current Opinion in Cell Biology 3, no. 4 (1991): 621–25. http://dx.doi.org/10.1016/0955-0674(91)90032-t.

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45

Machicote, A., P. Pelczar, M. Nawrocki, et al. "P038 Microbial regulation of T-cell fate towards regulatory profiles during T-cell transfer induced colitis." Journal of Crohn's and Colitis 15, Supplement_1 (2021): S150—S151. http://dx.doi.org/10.1093/ecco-jcc/jjab076.167.

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Abstract Background During Inflammatory Bowel Diseases (IBD), CD4+ effector T cells are main mediators of the tissue damage. Among them, Th17 cells strongly contribute to the inflammatory response. Interestingly, our lab previously showed that Th17 cells can convert into regulatory T cells, thereby controlling inflammation. However, the forces controlling the plasticity of T cells during IBD remain largely unknown. Our aim is to understand, how CD4+ T-cell plasticity can be modulated from a pro-inflammatory towards an anti-inflammatory profile during IBD. It is currently known that both Th17 a

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46

Yasukawa, Masaki, Toshiki Ochi, and Hiroshi Fujiwara. "Adoptive T-cell immunotherapy using T-cell receptor gene transfer: aiming at a cure for cancer." Immunotherapy 3, no. 2 (2011): 135–40. http://dx.doi.org/10.2217/imt.10.103.

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47

Miao, Y., V. LIndenberg, Y. Adesokan, et al. "1955P Glycan-programmed T cell immunity: Effective adoptive T cell transfer in a CRC preclinical model." Annals of Oncology 35 (September 2024): S1131—S1132. http://dx.doi.org/10.1016/j.annonc.2024.08.2040.

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48

Tay, Neil Q., Tiffany Juan, Joseph J. Muldoon, Justin Eyquem, and Michael T. McManus. "Abstract 6633: Tracking cell-cell interactions using intercellular barcode transfer." Cancer Research 84, no. 6_Supplement (2024): 6633. http://dx.doi.org/10.1158/1538-7445.am2024-6633.

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Abstract Cell-cell interaction is one of the fundamental biological mechanisms by which cells communicate and is a key modality by which cancer cells interact with other cells in their microenvironment. Current methods, such as enzymatic labeling and proximity-based tagging, allow the experimental tracking of these interactions but are not compatible with sequencing-based readouts, which are essential for high-throughput analyses. We have developed a highly scalable intercellular barcode transfer technology that bridges this gap. Our novel “Relay” technology offers a scalable solution to monit

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Romball, C. G., and W. O. Weigle. "Transfer of experimental autoimmune thyroiditis with T cell clones." Journal of Immunology 138, no. 4 (1987): 1092–98. http://dx.doi.org/10.4049/jimmunol.138.4.1092.

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Abstract We have investigated three T lymphocyte clones isolated from CBA/CaJ mice primed with mouse thyroid extract (MTE) in adjuvant. All three clones are L3T4+, Ig-, and Lyt2- and proliferate to MTE, mouse thyroglobulin (MTG) and rat thyroid extract. Clones A7 and B7 transfer thyroiditis to irradiated (475 rad) syngeneic mice, but not to normal recipients. The thyroid lesion induced by the B7 clone is characterized by the infiltration of both mononuclear and polymorphonuclear cells. The thyroiditis is transient in that lesions are apparent 7 and 14 days after transfer, but thyroids return t

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Vanham, Guido, Lieve Penne, Heidi Allemeersch, et al. "Modeling HIV transfer between dendritic cells and T cells: importance of HIV phenotype, dendritic cell– T cell contact and T-cell activation." AIDS 14, no. 15 (2000): 2299–311. http://dx.doi.org/10.1097/00002030-200010200-00011.

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