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Dissertations / Theses on the topic 'T-cell receptor'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Soper, David Michael. "Interleukin-2 receptor and T cell receptor signaling in regulatory T cells /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8344.

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2

Carson, Bryan David. "Impaired T cell receptor signaling in regulatory T cells /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8337.

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3

Im, Jin Seon. "Molecular characterization of T cell receptors and non-MHC restricted T cell receptor binding peptides." Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/284969.

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T cells recognize antigenic peptides presented by MHC molecules on antigen presenting cells (APC) through T cell receptors (TCRs). Since TCRs are very similar to antibodies in structure and genetics, TCRs might have the potential to bind free antigens as antibodies do. Here, peptides which bound TCRs irrespective of MHC molecules have been identified by screening "one-bead one-peptide" combinatorial libraries. Peptides: VRENAR, RTGNYV, GKMHFK, KDAVKR and RKPQAI bound recombinant Jurkat single chain T cell receptors (scTcrs). GKMHFK, KDAVKR and RKPQAI were also specific for natural TCRs on the

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4

Jiang, Ning. "Kinetic analysis of Fcγ receptor and T cell receptor interacting with respective ligands". Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/26716.

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Low affinity Fcg receptor III (FcgRIII, CD16) triggers a variety of cellular events upon binding to the Fc portion of IgG. A real-time flow cytometry method was developed to measure the affinity and kinetics of such low affinity receptor/ligand interactions, which was shown as an easily operated yet powerful tool. Results revealed an unusual temperature dependence of reverse rate of CD16aTM dissociating from IgG. Except for a few studies using mammalian cell CD16s, most kinetics analyses use purified aglycosylated extracellular portion of the molecules, making it impossible to assess the impor

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5

Butcher, Sarah A. "T cell receptor genes of influenza A haemagglutinin specific T cells." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315271.

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6

Sommermeyer, Daniel. "Generation of dual T cell receptor (TCR) T cells by TCR gene transfer for adoptive T cell therapy." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16051.

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Die Herstellung von T-Zellen mit definierten Spezifitäten durch den Transfer von T-Zellrezeptor (TCR) Genen ist eine effiziente Methode, um Zellen für eine Immuntherapie bereitzustellen. Eine besondere Herausforderung ist dabei, ein ausreichend hohes Expressionsniveau des therapeutischen TCR zu erreichen. Da T-Zellen mit einem zusätzlichen TCR ausgestattet werden, entsteht eine Konkurrenzsituation zwischen dem therapeutischen und dem endogenen TCR. Bevor diese Arbeit begonnen wurde war nicht bekannt, welche TCR nach einem Gen-Transfer exprimiert werden. Daher haben wir Modelle etabliert, in de

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7

Li, Xiaoying. "T cell receptor repertoires of immunodominant CD8 T cell responses to Theileria parva." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/19552.

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Previous research has provided evidence that CD8 T cells mediate immunity against infection with Theileria parva. However, the immunity induced by one parasite strain doesn‟t give complete protection against other strains and this is associated with parasite strain specificity of the CD8 T cell responses. There is evidence that such strain specificity is a consequence of the CD8 T cell responses of individual animals being focused on a limited number of immunodominant polymorphic peptide-MHC determinants. Dominant responses to the Tp2 antigen have been demonstrated in animals homozygous for th

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8

Wright, G. P. "Generation of antigen-specific regulatory T cells by T cell receptor gene transfer." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18952/.

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Regulatory T cells (Tregs) have shown considerable potential in the treatment of murine models of immuno-pathology. Whilst poly-clonal Tregs are able to suppress immuno-pathology in a number of models, the superiority of Ag-specific Treg treatment has been demonstrated using Tregs from T cell receptor (TCR)- transgenic animals. Translation of these promising results to the clinic has been hampered by difficulties in isolating or enriching the rare Ag-specific Tregs from the polyclonal population. Here I describe two distinct approaches to generate Ag-specific T cells with regulatory ability: f

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9

Moody, Anne Marie. "T-cell receptor studies in myasthenia gravis." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337448.

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10

Palmer, M. S. "Studies on the murine T-cell receptor." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379915.

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11

Downs, Anne-Marie. "Functional analysis of T-cell receptor gene transduced T-lymphocytes." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429389.

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12

Zarozinski, Christopher C. "T Cell Receptor-Dependent and Independent Events During Potent Anti-Viral T Cell Responses." eScholarship@UMMS, 1998. http://escholarship.umassmed.edu/gsbs_diss/175.

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The relative contribution of T cell receptor-dependent stimulation versus TcR-independent bystander stimulation in the massive increase in the number of activated proliferating CD8+ T cells seen during acute many acute viral infections is unclear. To determine if this increase was the result of TcR-independent bystander activation and proliferation, anti-viral cytotoxic T lymphocytes were induced in vivo via DNA immunization so that the anti-viral immune response could be examined in the absence of the high levels of cytokines generated during acute infection. After a single immunization with

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13

Tibbitt, Christopher Andrew. "The role of T cell receptor signal intensity in T helper 17 cell development." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/2885.

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T-helper (Th) 17 cells are a subset of CD4+ T cells defined through the release of the cytokine interleukin-17a (IL-17a). Activation of these cells is critical for protection against some extracellular bacterial and fungal pathogens. However, a dysregulated Th17 response targeted against self is thought to play an important role in the immunopathology of a number of autoimmune conditions including Inflammatory Bowel Disease (IBD), Multiple Sclerosis (MS) or inflammatory arthritides. Further understanding of the mechanisms that influence the development of Th17 cells may aid future therapeutic

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14

Tubb, Vanessa. "The development of novel T cell receptor, and chimeric antigen receptor, engineered T cell therapies for the treatment of cancer." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7725/.

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The ability to generate a tumour-reactive T cell compartment is possible through the genetic engineering of patient T cells with tumour-reactive TCRs or CARs. The clinical testing of such therapies is garnering increasingly encouraging results, particularly in haematological malignancies. However, identification of more potent and specific target antigens, and combating immunosuppression in the tumour microenvironment is necessary to transfer these clinical responses to solid tumours. We investigated whether recurrent cancer mutations encode immunogenic neoantigens presented by common HLA clas

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15

Okkenhaug, Klaus. "Signalling through the T cell costimulatory receptor CD28." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq41262.pdf.

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16

Vessey, S. J. R. "A molecular analysis of the T-cell receptor." Thesis, University of Oxford, 1997. http://ora.ox.ac.uk/objects/uuid:87b560f9-b1d6-4b12-9c94-fd1b4de397f6.

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The recognition of MHC-peptide ligands by the T cell receptor (TCR) is central to the induction of the adaptive immune response. This thesis describes the development of a bioassay for TCR recognition which was then used to undertake a molecular analysis of the TCR/MHC-peptide interaction. 1. A TCR-CD3ϛ chimeric receptor was stably expressed in the cell line RBL-2H3 to give the transfectant RBL-008. RBL-008 was shown to exhibit MHC-restricted peptide-specific responses to both cellular and multimerised recombinant HLA-A2-pol peptide targets (Chapter 3). 2. By competitively inhibiting the respo

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17

Fernandes, Ricardo A. "Controls on T-cell receptor phosphorylation and triggering." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:f0933a44-e1d6-4941-a541-c0cf903532ca.

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An effective immune response in mammalian cells relies on a network of molecular interactions to detect and respond to pathogens. The T-cell receptor (TCR) is one of the most important components of this system responsible for the outcome of the immunological response. Paramount to its role is its ability to efficiently signal a productive interaction with a peptide embedded in an MHC molecule. Important aspects of TCR structure and organization are unknown, limiting the current understanding of this process and rendering it highly controversial. The work described in this thesis seeks to defi

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18

Mukhopadhyay, Himadri. "Multisite phosphorylation in T cell receptor proximal signalling." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:25bd3d44-34eb-46d7-8ce8-fec2eb13b75b.

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T cell receptor proximal signalling represents a specific instance of a multisite phosphorylation system. Receptor phosphorylation is regulated by the opposing actions of the kinase LCK, and phosphatases such as CD45 and CD148. Particular phosphoforms recruit the kinase ZAP-70, which once bound, propagates downstream signalling. In this thesis we investigate the functional consequences of multiple phosphorylation sites on the dose-response profiles of receptor phosphorylation. We combine mathematical modelling with cellular reconstitution to assess the effect of multiple modification sites on

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19

Trop, Sebastien. "Regulation of T cell development by the pre-T cell receptor and the CD45 phosphatase." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37622.

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A molecular interplay between the signaling components utilized by cytokine receptors, the pre-T cell receptor (pre-TCR), and the T cell receptor (TCR) is presumed to be required for proper regulation of thymocyte development. The earliest intrathymic progenitors are known to depend on cytokine signaling. However, the mechanisms regulating cytokine signaling during thymopoiesis have not been characterized. Moreover, the contribution of cytokine signaling to the maturation of CD4-CD8- thymocytes into CD4+CD8+ thymocytes, mainly controlled by the pre-TCR, is uncertain. Overexpression of SOCS-1,

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20

Thomas, N. C. "Computational approaches to the study of T cell migration and the T cell receptor repertoire." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1426946/.

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Two pertinent questions in T cell immunology are addressed by using techniques from machine learning to describe T cell migration dynamics and characteristics of the T cell receptor repertoire. Naive T lymphocytes exhibit extensive antigen-independent recirculation between blood and lymph nodes, where they may encounter dendritic cells carrying cognate antigen. The time T cells may spend in an individual lymph node is estimated by analysing data from long term cannulation of blood and efferent lymphatics of a single lymph node in sheep. The distribution of transit times of migrating T cells is

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21

Stevens, C. N. "The interferon alpha receptor utilises T-cell receptor-associated proteins for signalling." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/15852/.

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The interferon alpha receptor (IFNAR) and T-cell receptor (TCR) are expressed upon the T-cell surface. The dimeric Class I interferon receptor is a cytokine receptor that recognises interferons such as IFNα. Interferons (IFNs) are pluripotent, antiviral cytokines that causes antiproliferative effects, primarily through Jak/STAT signalling. The T-cell receptor is an antigenic receptor that recognises antigenically-derived peptides in the context of the MHC complex located on an antigen presenting cell, resulting in a cellular proliferation. Although both receptors elicit opposing cellular outco

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22

Maciocia, P. M. "Targeting the T-cell receptor beta constant region for investigation and immunotherapy of T-cell malignancies." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1551063/.

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T-cell lymphomas and leukemias are aggressive, treatment-resistant cancers with poor prognosis. Immunotherapeutic approaches have been limited by a lack of target antigens discriminating malignant from healthy cells. While treatment of B-cell cancers has been enhanced by targeting pan B-cell antigens, an equivalent approach is not possible for T-cell malignancies since profound T-cell depletion, unlike B-cell depletion, would be prohibitively toxic. We propose an immunotherapeutic strategy for targeting a pan T-cell antigen without causing severe depletion of normal T-cells. The α/β T-cell rec

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23

Blish, Catherine Anne. "Modulation of T cell function and T cell receptor repertoire during the induction of peripheral tolerance /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8323.

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24

Malik, Amna. "Anti-CMV CD8+ T-cell epitope specificities and T-cell receptor repertoires in African study subjects." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:25b09543-3d8b-4340-a003-8ebe7827ee21.

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This work focuses on chronic viral infection in populations in sub-Saharan Africa. Although some of these viruses are endemic, there is a paucity of data charac- terising the immune responses in the relevant populations affected. The primary focus of this thesis is cytomegalovirus (CMV). Almost 90% of children in Africa are infected by the age of 12 months. A strong virus-specific immune response controls but does not clear CMV infection, and CMV typically remains latent; how- ever, reactivation is possible, particularly in the context of HIV infection and other states of immunosuppression. Th

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25

Sandalova, Elena. "Regulation of the pro-apoptotic protein bim by T cell receptor triggering in human T cells /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-041-1/.

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26

Gohil, Satyen Harish. "Pre-clinical development of novel ROR1 chimeric antigen receptor T cells and bispecific T cell engagers." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10042372/.

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Receptor tyrosine kinase like orphan receptor 1 (ROR1) is an onco-embryonic antigen present on a range of solid and haematological malignancies, including chronic lymphocytic leukaemia. Additionally, limited, low level expression on normal tissues makes it an attractive therapeutic target. Chimeric antigen receptor T cells and Bispecific T Cell Engagers have emerged as exciting immunotherapeutic approaches, utilising the inherent cytotoxic potential of autologous T cells to yield demonstrable benefit for patients. We therefore aimed to generate novel ROR1 CAR T cells and BiTEs. Following a rat

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27

Uttenthal, B. J. "T cell receptor-transduced regulatory T cells : functional studies in models of graft-versus-host disease." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1379030/.

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Alloreactive immune responses directed against malignant cells in recipients of allogeneic haematopoietic stem cell transplants are able to cure patients with haematological cancers. However, such immune responses may cause severe morbidity when directed against healthy recipient tissue, resulting in graft-versus-host disease (GvHD). Naturally occurring regulatory T cells (Tregs) are CD4+ T cells characterized by their expression of the transcription factor Foxp3. Whilst adoptively transferred polyclonal Tregs suppress GvHD in several murine models, their lack of specificity may compromise ben

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28

Pihlgren, Maria. "Phenotypic and functional characterisation of CD8 memory T cells generated in T cell receptor transgenic mice." Lyon, École normale supérieure (sciences), 1998. http://www.theses.fr/1998ENSL0086.

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La memoire immunitaire, c'est-a-dire la capacite du systeme immunitaire a repondre plus rapidement et plus efficacement vis-a-vis d'antigenes deja rencontres dans le passe, permet une immunite protectrice. Cependant, si la reponse immunitaire vis-a-vis d'antigenes secondaires est bien caracterisee, les bases cellulaires et moleculaires de la memoire immunitaire sont encore mal definies. Nous avons utilise des souris transgeniques pour le recepteur d'antigene de lymphocytes t afin de caracteriser la differenciation et le phenotype de lymphocytes t cd8 a memoire. Nos resultats montrent que la ma

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29

Kieback, Elisa. "A new safeguard eliminates T cell receptor gene-modified auto-reactive T cells after adoptive therapy." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2008. http://dx.doi.org/10.18452/15819.

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Der adoptive Transfer von TZR-modifizierten T Zellen ist mit potentiellen Risiken verbunden. Autoimmunreaktionen können auftreten, wenn Tumor-assoziierte Antigene auf normalem Gewebe erkannt werden, Fehlpaarung der TZR-Ketten zur Bildung eines autoreaktiven Rezeptors führen oder ein sonst anerger auto-reaktiver endogener Rezeptor aktiviert wird. Auch besteht das Risiko der malignen Transformation der Zelle durch Insertionsmutagenese. Daher ist es notwendig, die transferierten T Zellen im Fall schwerer Nebenwirkungen eliminieren zu können. Derzeit verfügbare Sicherheitsmechanismen sind für die

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30

Zhang, Hao. "T cell antigen receptor binding and initial signal transduction." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669994.

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31

Boucher, Louis-martin. "T-cell receptor associated signals that modulate lymphocyte homeostasis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0028/NQ49933.pdf.

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32

Duszczyszyn, Danielle Andrea. "T-cell receptor excision circle content in multiple sclerosis." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82228.

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The pathogenesis of Multiple Sclerosis (MS), a demyelinating disease of the central nervous system (CNS) with associated early axonal damage, is poorly understood. Considerable data indicate that MS is an inflammatory-mediated autoimmune disease. Normally, the naive T-cell niche is maintained by homeostatic mechanisms and in MS, naive T-cells play a central role in the autoimmune response against CNS antigens. Naive T-cells are produced by the thymus and naive T-cell production by the thymus can be ascertained by quantifying signal joint T-cell receptor excision circles (sjTRECs); episo

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33

Demaine, A. G. "Immunoglobulin and T cell receptor polymorphisms in immune disease." Thesis, Imperial College London, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376674.

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34

Habib-Nassif, Anne-Marie. "T cell receptor gene characterisation in experimental autoimmune glomerulonephritis." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412499.

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35

Choudhuri, Kaushik. "The mechanism of T cell receptor-mediated signal transduction." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433379.

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36

Chua, I. C. "CD8 co-receptor modifications to enhance T cell immunotherapy." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1419099/.

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TCR gene transfer can generate tumour antigen-specific T cells for adoptive immunotherapy. Following TCR gene transfer, transduced T cells usually display the same functional avidity as the parental clone from which the TCR was isolated. However, tumour-antigen specific T cells typically recognize over-expressed self-antigen and are often of low/moderate avidity. It is known that optimal recognition of target cells by CTL requires binding of the cognate peptide MHC class I complex (MHCI) by both TCR and the CD8 co-receptor. Some CD8β chain mutations have been shown to increase CD8 binding affi

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37

Moysi, Eirini. "T-cell receptor (TCR) usage in HIV-2 infection." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:ea3a066f-0043-4c71-88ec-2369de642460.

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Long-term non-progressors (LTPNs) in HIV infection target the structural protein Gag more frequently than individuals who progress to disease. However, the targeting of Gag per se does not always distinguish these two groups. Various factors have been put forth as likely explanations for this discrepancy including differences in the breadth and magnitude of observed responses, the HLA type of the host, the nature of the individual epitopes targeted and the ability of the virus to mutate these antigenic regions. The purpose of this thesis was to examine, using PBMCs isolated from HIV-2 infected

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38

Bunztman, Adam, Benjamin Vincent, Harsha Krovi, Shaun Steele, and Jeffrey Frelinger. "The LCMV gp33-specific memory T cell repertoire narrows with age." BioMed Central, 2012. http://hdl.handle.net/10150/610159.

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BACKGROUND:The memory response to LCMV in mice persists for months to years with only a small decrease in the number of epitope specific CD8 T cells. This long persistence is associated with resistance to lethal LCMV disease. In contrast to studies focused on the number and surface phenotype of the memory cells, relatively little attention has been paid to the diversity of TCR usage in these cells. CD8+ T cell responses with only a few clones of identical specificity are believed to be relatively ineffective, presumably due to the relative ease of virus escape. Thus, a broad polyclonal respons

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Laugel, Bruno. "Study of the interplay between antigen T-cell receptor and co-receptor in balancing the specificity and degeneracy of cytotoxic T-cell response." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437180.

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Brändle, Daniel. "Ontogeny of thymocytes and anti-viral cytotoxic T-cell responses studied in T-cell receptor transgenic mice /." [S.l.] : [s.n.], 1993. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10334.

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Shenderov, Eugene. "In vivo and In vitro Studies of T-Cell Receptor-ligland-MHC Affinity and T-Cell Function." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504593.

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Holland, Stephen. "The role of germline-encoded T cell receptor complementarity determining regions in T cell selection and function." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/10725.

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αβ T cell Receptors (TCR) recognise peptide antigen (p) presented on Major Histocompatability Complexes (MHC) via Complementarity Determining Regions (CDRs). TCRs are required to respond to a vast plethora of differing antigens and the CDR regions are suitably diverse, encoded by an array of gene-segments, which recombine during T cell development to generate diverse repertoires of TCRs. CDR1 and 2, which predominantly interact with the MHC, are encoded within gene-segments, and are subject to evolutionary pressure. However, CDR3 loops are non-germline and created through junctional diversity.

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Chain, Jennifer Lee. "Elucidating the mechanisms of the human [alphabeta] vs. [gammadelta] lineage decision and the details of [gammadelta] thymocyte development." Oklahoma City : [s.n.], 2005.

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Robinot, Rémy. "Lymphomes Natural-Killer T cells (NKT) : impact des stimulations antigéniques chroniques et mécanismes de la lymphomagénèse." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1255/document.

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Les lymphomes T périphériques (PTCL) sont des néoplasmes rares et agressifs représentant environ 12% des lymphomes chez l’Homme. Nos travaux récents dans des souris p53-/- ont révélé une nouvelle entité de PTCL, émergeant de cellules Natural-Killer T-cell (NKT), un type particulier de lymphocyte T reconnaissant des antigènes lipidiques. Nous avons montré que ces lymphomes NKT (PTCL-NKT) présentent des caractéristiques de NKT stimulés chroniquement, et que la lymphomagenèse est initiée via l’activation chronique du TCR. Chez l’Homme, de nombreux PTCL sont suspectés pour être associés à des stim

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Pollard, Tracey Elizabeth. "A study of T-cell receptor usage in allergic asthma and analysis of a humanised T-cell receptor transgenic model of immunity to allergen." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/11868.

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Ueda, Maki. "Expression of functional interleukin-21 receptor on adult T-cell leukaemia (ATL) cells." Kyoto University, 2005. http://hdl.handle.net/2433/144754.

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Fairbairn, Camilla Jayne. "Searching for the missing T Cell Receptor (TCR) in Anaplastic Large Cell Lymphoma (ALCL) : surplus to requirements or a protagonist in lymphomagenesis?" Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/273245.

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Anaplastic Large Cell Lymphoma (ALCL) is a peripheral T cell lymphoma divided into three distinct entities: ALCL, Anaplastic Lymphoma Kinase (ALK)+, ALCL ALK- and cutaneous ALCL. In the majority of ALCL, ALK+, ALK is expressed as the result of a chromosomal translocation generating Nucleophosmin 1(NPM)-ALK, which is considered the main driver. ALCL have an unusual immunophenotype; they rarely express a T cell receptor (TCR), but are often positive for CD4 and produce cytotoxic proteins such as perforin and Granzyme B, but in the absence of CD8, questioning the origin and pathogenesis of this m

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48

Böhm, Stefanie [Verfasser], and Lars [Akademischer Betreuer] Nitschke. "Adoptive T-cell-receptor transfer to examine human T-cell immunology in vitro / Stefanie Böhm. Betreuer: Lars Nitschke." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2013. http://d-nb.info/1033688193/34.

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Bas, Anna. "Extrathymic T cell receptor gene rearrangement in human alimentary tract." Doctoral thesis, Umeå University, Clinical Microbiology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169.

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<p>T lymphocytes regulate the initiation, duration, and magnitude of adaptive immune responses and function as effector cells in cell mediated immunity. To become immunologically competent they must generate functional antigen receptors. This process takes place in the thymus and requires somatic recombination of T cell receptor (TCR) genes. It is mediated by the endonucleases recombination activating gene-1 (RAG1) and RAG2. Although the thymus regresses at puberty, T cells are present throughout life implying that other tissues must provide the proper milieu for T cell development. This thesi

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Cannons, Jennifer. "Signal transduction by the T cell costimulatory receptor, 4-1BB." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63680.pdf.

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