Dissertations / Theses on the topic 'T-cell mediated immunity'
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Abdulahad, Wayel Habib. "T-cell mediated immunity in Wegener's granulomatosis." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/.
Full textLindencrona, Jan Alvar. "Enhancing T cell mediated immunity in DNA vaccination /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-710-x.
Full textLee, Laurel Yong-Hwa. "T cell mediated immunity to influenza in humans." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670049.
Full textLiew, F. Y. "Cell mediated-immunity against infectious diseases." Thesis, Canberra, ACT : The Australian National University, 1990. http://hdl.handle.net/1885/142999.
Full textHu, Yong. "Altered T Cell-Mediated Immunity and Infectious Factors in Autism." DigitalCommons@USU, 2000. https://digitalcommons.usu.edu/etd/6846.
Full textLing, Khoon Lin. "Investigations into T cell mediated tumour immunity in the colon." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422657.
Full textBorysiewicz, L. K. "Cell mediated immunity to human cytomegalovirus infection (cytotoxic T cell and natural killer cell mediated lysis of human cytomegalovirus infected cells)." Thesis, Imperial College London, 1986. http://hdl.handle.net/10044/1/37949.
Full textHaßel, Silvana Katharina [Verfasser]. "Aptamers for targeted activation of T cell-mediated immunity / Silvana Katharina Haßel." Bonn : Universitäts- und Landesbibliothek Bonn, 2016. http://d-nb.info/1162953004/34.
Full textKlemetti, Paula. "T-cell mediated immunity in the pathogenesis of insulin-dependent diabetes mellitus." Helsinki : University of Helsinki, 1999. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/klemetti/.
Full textAgrawal, T. "Epithelial ErbB2 regulation of thymus homeostasis and age-associated T cell mediated immunity." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10048131/.
Full textMazahery, Claire. "CD8+ T Cell Mediated Immunity is Disrupted by Ex Vivo and In Vivo Opioid Use." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1587376234022407.
Full text柴山, 史朗. "IFN-α Directly Promotes Programmed Cell Death-1 Transcription and Limits the Duration of T Cell-Mediated Immunity." 京都大学, 2011. http://hdl.handle.net/2433/147347.
Full textXu, Dan. "Cellular Immunity in Recombinant Adeno-Associated Virus Vector Mediated Gene Therapy." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313504203.
Full textKaveh, Daryan Alexander. "Mechanisms of BCG-induced CD4 T cell-mediated immunity against mycobacterium bovis in the BALB/c mouse." Thesis, St George's, University of London, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.676097.
Full textMayes, Kimberly. "The Role of the Nucleosome Remodeling Factor NURF in Inhibiting T and Natural Killer Cell Mediated Antitumor Immunity by Suppressing Tumor Antigenicity and Natural Cytotoxicity Receptor Co-ligands." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4770.
Full textGodoy, Ramirez Karina. "Flow cytometric methods for assessment of cell-mediated immune responses /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-409-0/.
Full textKastenmüller, Kathrin [Verfasser], Dirk [Akademischer Betreuer] Busch, Wolfgang [Akademischer Betreuer] Wurst, and Siegfried [Akademischer Betreuer] Scherer. "Generation of CD8+ T cell mediated protective immunity upon vaccination with soluble antigen : involvement of immunmodulatory factors like adjuvant or regulatory lymphocytes / Kathrin Kastenmüller. Gutachter: Wolfgang Wurst ; Siegfried Scherer. Betreuer: Dirk Busch." München : Universitätsbibliothek der TU München, 2006. http://d-nb.info/1058141163/34.
Full textJudge, Chelsey J. "IL-7-MEDIATED CD56BRIGHT NK CELL FUNCTION IS IMPAIRED IN HCV IN PRESENCE AND ABSENCE OF CONTROLLED HIV INFECTION, WHILE CD14BRIGHTCD16- MONOCYTES NEGATIVELY CORRELATE WITH CD4 MEMORY T CELLS AND HCV DECLINE DURING HCV-HIV CO-INFECTION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1481187921533387.
Full textScheckelhoff, Mark R. "Specific T cell repertoires mediate protective immunity to Histoplasma capsulatum." Cincinnati, Ohio : University of Cincinnati, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=ucin1051292258.
Full textSCHECKELHOFF, MARK ROBERT. "SPECIFIC T CELL REPERTOIRES MEDIATE PROTECTIVE IMMUNITY TO HISTOPLASMA CAPSULATUM." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1051292258.
Full textShaan, Lakshmanappa Yashavanth. "Development and Evaluation of Efficacy of Novel Porcine Reproductive and Respiratory Syndrome (PRRS) Virus Vaccine Candidates in Pigs." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1532064253191032.
Full textMcdaniel, Jessica Marie. "Lenalidomide targets the T-cell co-stimulatory pathway to mediate immune modulation." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4367.
Full text"Ex vivo imaging immune cell interactions in T cell vaccine-induced immunity and CD8+CD25+ T regulatory cell-mediated immune suppression." Thesis, 2013. http://hdl.handle.net/10388/ETD-2013-10-1254.
Full textHa, Sung Pil. "CD4+ T cell mediated tumor immunity following transplantation of TRP-1 TCR gene modified hematopoietic stem cells." Thesis, 2013. http://hdl.handle.net/1805/3739.
Full textImmunotherapy for cancer has held much promise as a potent modality of cancer treatment. The ability to selectively destroy diseased cells and leave healthy cells unharmed has been the goal of cancer immunotherapy for the past thirty years. However, the full capabilities of cancer immunotherapies have been elusive. Cancer immunotherapies have been consistently hampered by limited immune reactivity, a diminishing immune response over time, and a failure to overcome self-tolerance. Many of these deficiencies have been borne-out by immunotherapies that have focused on the adoptive transfer of activated or genetically modified mature CD8+ T cells. The limitations inherent in therapies involving terminally differentiated mature lymphocytes include limited duration, lack of involvement of other components of the immune system, and limited clinical efficacy. We sought to overcome these limitations by altering and enhancing long-term host immunity by genetically modifying then transplanting HSCs. To study these questions and test the efficiency of gene transfer, we cloned a tumor reactive HLA-DR4-restricted CD4+ TCR specific for the melanocyte differentiation antigen TRP-1, then constructed both a high expression lentiviral delivery system and a TCR Tg expressing the same TCR genes. We demonstrate with both mouse and human HSCs durable, high-efficiency TCR gene transfer, following long-term transplantation. We demonstrate the induction of spontaneous autoimmune vitiligo and a TCR-specific TH1 polarized memory effector CD4+ T cell population. Most importantly, we demonstrate the destruction of subcutaneous melanoma without the aid of vaccination, immune modulation, or cytokine administration. Overall, these results demonstrate the creation of a novel translational model of durable lentiviral gene transfer, the induction of spontaneous CD4+ T cell immunity, the breaking of self-tolerance, and the induction of anti-tumor immunity.
Chang, Ping-Fang, and 張萍芳. "Infection of ENU mutant mice with Human Herpes Simplex Virus-1 (HSV-1) to investigate the effects of IL-15 splice variant on CD8+ T cell-mediated immunity." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/04566456844540081781.
Full textBowers, Edith Villette. "Receptor-Mediated Antigen Delivery by Α2-Macroglobulin: Effect on Cytotoxic T Lymphocyte Immunity and Implications for Vaccine Development." Diss., 2009. http://hdl.handle.net/10161/1319.
Full textThe receptor-recognized form of α2-macroglobulin (α2M*) targets antigens (Ag) to professional Ag-presenting cells (APCs) for rapid internalization, processing, and presentation. When employed as an Ag delivery vehicle, α2M* amplifies major histocompatibility complex (MHC) class II presentation as demonstrated by increased antibody (Ab) titers. Recent evidence, however, suggests that α2M*-encapsulation may also enhance Ag-specific cytotoxic T lymphocyte (CTL) immunity. In these studies, we demonstrate that α2M*-delivered Ag (ovalbumin, OVA) enhances the production of specific
Murine splenocytes expressing a transgenic T cell receptor (TCR) specific for CTL peptide OVA257-264 (SIINFEKL) demonstrated up to 25-fold greater IFN-γ and IL-2 secretion when treated
We also observed enhanced humoral and CTL responses by naïve mice following intradermal immunization with α2M*-OVA. These α2M*-OVA-immunized mice displayed increased protection against a subcutaneously implanted OVA-expressing tumor, as demonstrated by delayed tumor growth and prolonged animal survival. The anti-tumor response observed with α2M*-mediated Ag delivery was comparable to that of an accepted vaccine adjuvant (CpG 1826) and appeared superior to a cell-based vaccine technique.
To further understand the mechanism underlying this enhanced CTL immunity, the subsets of professional APCs capable of cross-presenting α2M*-encapsulated Ag were investigated. Although both dendritic cells (DCs) and macrophages appear to stimulate some degree of cross-priming in response to α2M*-encapsulated Ag, CD8
These observations demonstrate that α2M*-mediated Ag delivery promotes cross-presentation resulting in enhanced Ag-specific CTL immunity. Considered in the context of previous work, these results support α2M* as an effective Ag delivery system that may be particularly useful for vaccines based on weakly immunogenic subunits or requiring dose sparing.
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