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Academic literature on the topic 'T cell diversity'

Author: Grafiati

Published: 5 October 2024

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Journal articles on the topic "T cell diversity"

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Newrzela, S., N. Al-Ghaili, T. Heinrich, M. Petkova, S. Hartmann, B. Rengstl, A. Kumar, et al. "T-cell receptor diversity prevents T-cell lymphoma development." Leukemia 26, no. 12 (May 30, 2012): 2499–507. http://dx.doi.org/10.1038/leu.2012.142.

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Stromberg, Sean P., and Jean M. Carlson. "Diversity of T-cell responses." Physical Biology 10, no. 2 (March 15, 2013): 025002. http://dx.doi.org/10.1088/1478-3975/10/2/025002.

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GORONZY, J., W. LEE, and C. WEYAND. "Aging and T-cell diversity☆." Experimental Gerontology 42, no. 5 (May 2007): 400–406. http://dx.doi.org/10.1016/j.exger.2006.11.016.

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Nelson, J. "STKE: Celebrating T Cell Diversity." Science 295, no. 5557 (February 8, 2002): 933b—933. http://dx.doi.org/10.1126/science.295.5557.933b.

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Robins, Harlan S., Paulo V. Campregher, Santosh K. Srivastava, Abigail Wacher, Cameron J. Turtle, Orsalem Kahsai, Stanley R. Riddell, Edus H. Warren, and Christopher S. Carlson. "Comprehensive assessment of T-cell receptor β-chain diversity in αβ T cells." Blood 114, no. 19 (November 5, 2009): 4099–107. http://dx.doi.org/10.1182/blood-2009-04-217604.

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Abstract The adaptive immune system uses several strategies to generate a repertoire of T- and B-cell antigen receptors with sufficient diversity to recognize the universe of potential pathogens. In αβ T cells, which primarily recognize peptide antigens presented by major histocompatibility complex molecules, most of this receptor diversity is contained within the third complementarity-determining region (CDR3) of the T-cell receptor (TCR) α and β chains. Although it has been estimated that the adaptive immune system can generate up to 1016 distinct αβ pairs, direct assessment of TCR CDR3 diversity has not proved amenable to standard capillary electrophoresis-based DNA sequencing. We developed a novel experimental and computational approach to measure TCR CDR3 diversity based on single-molecule DNA sequencing, and used this approach to determine the CDR3 sequence in millions of rearranged TCRβ genes from T cells of 2 adults. We find that total TCRβ receptor diversity is at least 4-fold higher than previous estimates, and the diversity in the subset of CD45RO+ antigen-experienced αβ T cells is at least 10-fold higher than previous estimates. These methods should prove valuable for assessment of αβ T-cell repertoire diversity after hematopoietic cell transplantation, in states of congenital or acquired immunodeficiency, and during normal aging.

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Sato, Kayoko. "Helper T Cell Diversity and Plasticity." Circulation Journal 78, no. 12 (2014): 2843–44. http://dx.doi.org/10.1253/circj.cj-14-1164.

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Born, Willi K., M. Kemal Aydintug, and Rebecca L. O'Brien. "Diversity of γδ T-cell antigens." Cellular & Molecular Immunology 10, no. 1 (October 22, 2012): 13–20. http://dx.doi.org/10.1038/cmi.2012.45.

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Parish, Ian A., and Susan M. Kaech. "Diversity in CD8+ T cell differentiation." Current Opinion in Immunology 21, no. 3 (June 2009): 291–97. http://dx.doi.org/10.1016/j.coi.2009.05.008.

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Nakayamada, Shingo, Hayato Takahashi, Yuka Kanno, and John J. O'Shea. "Helper T cell diversity and plasticity." Current Opinion in Immunology 24, no. 3 (June 2012): 297–302. http://dx.doi.org/10.1016/j.coi.2012.01.014.

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Kemir, C. "Diversity of Human T Cell Receptors." Science 288, no. 5469 (May 19, 2000): 1135a—1135. http://dx.doi.org/10.1126/science.288.5469.1135a.

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Dissertations / Theses on the topic "T cell diversity"

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Golby, Sarah Jane Charity. "Diversity of T cell subsets in mucosal microenvironments." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369221.

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Furmanski, Anna Louise. "Diversity and selection of the murine T-cell repertoire." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434779.

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Lee, Edward S. "Quantifying the development, size, and repertoire diversity of T cell populations." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/31002/.

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The adaptive immune system must be able to respond to virtually any pathogen that the body encounters. T cell immunity is able to do so by developing a diverse repertoire of T cell receptors and maintaining large numbers of T cells. These two quantitative properties are fundamental for the ability of T cell-mediated immunity to clear infections and generate memory cells for future protection. The aims of this thesis are to quantify the sizes of T cell populations, to develop tools to measure the diversity of T cell repertoires, and to describe how T cell populations develop in neonatal mice. We studied the development of T cell populations in neonatal mice by measuring cell counts and Ki67 expression in thymocyte and peripheral T cell subsets from mice soon after birth to late adulthood. The presumed lymphopenic environment of the neonatal mouse is thought to cause T cells to undergo lymphopenia-induced proliferation, and we wanted to quantify the balance between thymic output and peripheral expansion in the naive T cell compartment during development with mathematical modeling. We also used modeling to find the most parsimonious description of differentiation within the thymus that explains the dynamically growing thymus. We then sought to quantify the sizes of the peripheral T cell compartments in the adult mouse. Understanding the characteristics of healthy T cell immunity requires knowing the precise numbers of the different T cell subsets found in the body. We performed thoracic duct cannulations in adult mice to collect recirculating T cells and reduce cell numbers in the lymph nodes and spleens; by counting the number of collected T cells and its effect on cell numbers on the secondary lymphoid organs, we sought to back-calculate the total number of T cells in the mouse. Finally, we developed tools that provide high-throughput and cost-effective methods for identifying paired TCR sequences. By using computational techniques, we were able to adapt standard sequencing protocols to identify many paired TCR sequences without resorting to large and expensive single-cell sequencing techniques. By leveraging experimental design with mathematical methods, we were able to quantify and characterize many properties of effective T cell immunity.

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Trichot, Coline. "Regulation of Human T Helper Cell Diversity : From In Vitro Dendritic Cell-Based Mechanisms to Candidate Biomarkers in Atopic Dermatitis." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS423.

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Le système immunitaire humain est majoritairement commandé par les cellules dendritiques et les lymphocytes T auxiliaires. Lorsque les cellules dendritiques détectent un pathogène, elles vont instruire les lymphocytes T auxiliaires afin qu’ils adoptent le phénotype approprié à la menace rencontrée. Les lymphocytes T auxiliaires peuvent être divisés en plusieurs sous-populations, caractérisées par la production de cytokines spécifiques. Chaque sous-population de lymphocyte T auxiliaire possède des fonctions propres et est impliquée dans l’élimination de pathogènes distincts. Si les réponses des lymphocytes T auxiliaires ne sont pas finement régulées, ils peuvent devenir pathogéniques, et dans ce cas, considérés comme cibles potentielles pour des thérapies. Dans ce contexte, j’ai concentré mon travail de doctorat sur l’étude de la diversité des sous- populations de lymphocytes T auxiliaires et de leur régulation. Premièrement, j’ai démontré que les cellules dendritiques activées par la TSLP sont capables d’induire la polarisation de lymphocytes T folliculaires. Ensuite, j’ai participé à la construction d’un modèle mathématique capable de prédire la réponse lymphocytaire T auxiliaire en fonction de signaux dérivés des cellules dendritiques. Ce modèle nous a permis d’identifier un rôle spécifique pour l’IL-12p70, dépendant du contexte IL-1, dans l’induction d’IL-17F sans IL-17A. Enfin, j’ai monitoré huit populations de lymphocytes T auxiliaires et folliculaires dans le sang périphérique de patients atteints de dermatite atopique traités par Dupilumab, une immunothérapie ciblant la sous-unité alpha du récepteur de l’IL-4 et j’ai pu montré que la diminution du pourcentage de lymphocytes Th17 correlait avec l’amélioration du score clinique EASI. Globalement, mon travail sur la diversité de phénotypes Th apporte une ressource mécanistique importante, avec une potentielle application en immunothérapie
Human immunity is essentially driven by dendritic cells and T helper cells. When dendritic cells detect a pathogen, they will instruct T helper cells to adopt the adapted phenotype for the specific threat encountered. T helper cells are subdivided in multiple subsets, characterized by particular sets of cytokines. Each T helper subset has specific functions and is involved in the clearance of distinct pathogens. If T helper responses are not precisely regulated, they can become pathogenic, in this case T helper pathways can be considered as potential targets for therapy. In this context, I focused my PhD work on studying T helper cell subset diversity and regulation. First, I demonstrated the ability of TSLP-activated dendritic cell to induce T follicular helper cell polarization. Then I participated in building a mathematical model capable of predicting T helper cell response to dendritic-cell derived signals. This model allowed us to identify the specific role of IL-12p70, in an IL-1 context, to induce IL-17F without IL-17A. Finally, I monitered eight T helper and T follicular helper cell populations in peripheral blood from atopic dermatitis patients treated with Dupilumab, an immunotherapy targeting the IL-4 receptor alpha subunit, and was able to show a correlation between decrease of Th17 cell percentage and improvement of EASI clinical score. Overall, my work on Th phenotype diversity provides key mechanistic insight with potential application in immunotherapy

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Stirk, Emily Ruth. "Stochastic modelling of diversity and ageing in the naive T cell repertoire." Thesis, University of Leeds, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531516.

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Brookes, Roger Hamilton. "Generation of diversity in T cell epitope hierarchy by different routes of immunisation with simian immunodeficiency virus core protein." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283133.

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Singh, Ogesh. "Regulatory T cell diversity analysis and a gene transfer approach to cellular immunotherapy in a murine model of type one diabetes." Thesis, Royal Veterinary College (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522749.

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Jurewicz, Mollie M. "The non-classical MHC-II molecule DO regulates diversity of the immunopeptidome and selection of the CD4 regulatory T cell lineage." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1030.

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Presentation of antigenic peptides on MHC-II molecules is essential for induction of tolerance to self and for effective immunity against foreign pathogens. The non- classical MHC-II molecule DO (HLA-DO in humans, H2-O in mice) functions in selection of MHC-II epitopes by competitively inhibiting the peptide exchange factor DM. Previous studies have suggested a role for DO in development of autoimmunity and in the immune response to retroviral infection, presumably via modulation of the MHC-II peptidome, but the precise effect of DO has been difficult to discern. Through characterization of the full spectrum of peptides from DO-sufficient and DO-deficient cells, we demonstrate that DO functions to broaden the diversity of peptide species presented on MHC-II. DO is regulated differently from other components of the MHC-II processing machinery, with expression limited to B cell and dendritic cell subsets, as well as thymic epithelial cells, suggesting a role for DO in mediating central tolerance. In a mouse model lacking DO, we show that selection of T regulatory cells (Tregs) is increased and that DO- deficient Tregs are more activated and exert greater suppressive capacity. Despite augmented Treg function, mice lacking DO display enhanced susceptibility to autoimmunity, with altered germinal center (GC) Tregs and B cells indicative of an aberrant GC reaction. These data suggest that DO expression serves to fine-tune the immunopeptidome in order to promote self-tolerance to a wide spectrum of epitopes and to select a Treg population with appropriate specificity for self- antigens.

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Ameres, Stefanie Verfasser], and Horst [Akademischer Betreuer] [Domdey. "The T cell repertoire specific for the IE-1 protein of human cytomegalovirus : diversity, function and evasion / Stefanie Ameres. Betreuer: Horst Domdey." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/104831099X/34.

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Karpf, Léa. "Systematic Study of OX40 Ligand Context-Dependent Function on Human T Helper Cell Polarization A Quantitative Multivariate Model of Human Dendritic Cell-T Helper Cell Communication TH Cell Diversity and Response to Dupilumab in Patients With Atopic Dermatitis Inborn Errors of Type I IFN Immunity in Patients With Life-Threatening COVID-19 Quantitative Modeling of OX40 Ligand Context-Dependent Function on Human T Helper Cell SARS-CoV-2 Induces Activation and Diversification of Human Plasmacytoid Pre-Dendritic Cells." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL044.

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L'immunité adaptative est principalement orchestrée par des lymphocytes T CD4 auxiliaires. Ils ont la capacité de se polariser en plusieurs sous-populations, chacune associée à un phénotype approprié au pathogène rencontré. L'activation des lymphocytes T auxiliaires peut être régulée par des checkpoints immunitaires co-stimulateurs, tel que OX40 Ligand, ou co-inhibiteurs. Ces molécules ont été étudiées individuellement, dans des conditions spécifiques. Cependant, la contexte-dépendance pourrait expliquer une grande partie de la variabilité fonctionnelle des biomolécules. Il n'y a actuellement aucune méthode permettant d’analyser et de quantifier la contexte-dépendance d’une molécule dans plusieurs contextes et sur une réponse donnée.Mon projet de thèse a porté sur la fonction de OX40L sur la polarisation des cellules T auxiliaires, dans 4 contextes moléculaires et 11 cellulaires. Nous avons mesuré 17 cytokines T auxiliaires et développé une stratégie de modélisation statistique pour quantifier la contexte-dépendance deOX40L. Les scores de contexte-dépendance se sont révélés très variables qualitativement et quantitativement, en fonction de la cytokine et du type de contexte. Parmi les contextes Th, Th2 était le plus influent sur la fonction OX40L. Parmi les contextes DC, le type de cellules dendritique était dominant dans le contrôle de la contexte-dépendance de OX40L plutôt que le stimuli d’activation. Mon travail de thèse dévoile les complexes déterminants de la fonction de OX40L, fournit une méthode unique pour quantifier la variabilité fonctionnelle contexte-dépendante de n’importe quelle biomolécule et appuie sur le fait que la contexte-dépendance devrait être davantage prise en considération dans les études futures
Adaptive immunity is mainly orchestrated by CD4 T helper cells. They have the ability to polarize in several subsets, each associated to a suitable phenotype for the encounter pathogen. T helper cell activation can be regulated by co-stimulator, such as OX40 Ligand, or co-inhibitor immune checkpoint molecules. These molecules have been studied individually, in specific conditions. However, context-dependency may explain large parts of the functional variability of biological molecules on a given output. Currently, there is no framework to analyze and quantify context-dependency of a molecule over multiple contexts and response outputs. My PhD project focused on OX40L function on T helper cell polarization, in 4 molecular and 11 cellular contexts. We measured 17 T helper cytokines and developed a statistical modeling strategy to quantify OX40L context-dependency on these cytokines. This revealed highly variable qualitative and quantitative context-dependency scores, depending on the output cytokine and context type. Among molecular contexts, Th2 was the most influential on OX40L function. Among cellular contexts, dendritic cell type rather than activating stimulus was dominant in controlling OX40L contextdependency. My thesis work unveils the complex determinants of OX40L function, provides a unique framework to quantify the context-dependent functional variability of any biomolecule, and supports that context-dependency should be more taken into consideration in future studies

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Books on the topic "T cell diversity"

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B, Schook Lawrence, Tew John G, and International RES Symposium (1987 : Richmond, Va.), eds. Antigen presenting cells: Diversity, differentiation, and regulation : proceedings of a symposium held in Richmond, Virginia, March 26-29, 1987. New York: Liss, 1988.

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Galley, Kevin Andrew. Analysis of junctional region diversity of TCR[beta] cDNA from pancreatic islet-infiltrating T cells of young prediabetic nonobese diabetic mice. Ottawa: National Library of Canada, 1994.

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Soboloff, Jonathan, and Dietmar J. Kappes. Signaling Mechanisms Regulating T Cell Diversity and Function. Taylor & Francis Group, 2017.

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Soboloff, Jonathan, and Dietmar J. Kappes. Signaling Mechanisms Regulating T Cell Diversity and Function. Taylor & Francis Group, 2017.

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Soboloff, Jonathan, and Dietmar J. Kappes. Signaling Mechanisms Regulating T Cell Diversity and Function. Taylor & Francis Group, 2021.

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Soboloff, Jonathan, and Dietmar J. Kappes. Signaling Mechanisms Regulating T Cell Diversity and Function. Taylor & Francis Group, 2017.

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Soboloff, Jonathan, and Dietmar J. Kappes. Signaling Mechanisms Regulating T Cell Diversity and Function. Taylor & Francis Group, 2017.

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Signaling Mechanisms Regulating T Cell Diversity and Function. Taylor & Francis Group, 2017.

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Klingenberg, Roland, and Ulf Müller-Ladner. Mechanisms of inflammation. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0270.

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This chapter provides a brief summary of the immune pathogenesis of atherosclerosis, highlighting shared features with inflammatory pathways in rheumatoid arthritis (RA) described in detail in Chapter 25.4. RA constitutes a prototype autoimmune disease primarily affecting the joints but also the heart and vessels associated with increased cardiovascular mortality. Recent years have produced a wealth of novel insights into the diversity of immune cell types which either propagate or dampen inflammation in atherogenesis. Expansion of this inherent anti-inflammatory component carried by regulatory T cells may constitute a new therapeutic target to harness the progression of atherosclerotic cardiovascular disease. Among the various inflammatory mediators involved in RA pathology, cytokines (tumour necrosis factor-α‎ and interleukin-6) have gained major interest as therapeutic targets with approved therapies available. In light of the many common features in the pathogenesis of RA and atherosclerosis, these biologics are currently being evaluated in cardiovascular patients. The recently published CANTOS trial showed that IL-1 inhibition reduced adverse cardiovascular events in patients with coronary artery disease demonstrating that inflammation is a genuine therapeutic target. The near future will provide more information whether inflammation is a bona fide cardiovascular risk factor based on completion of several clinical trials using anti-inflammatory approaches in patients with both cardiovascular disease and rheumatoid arthritis.

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Liede-Schumann, Sigrid, Ulrich Meve, Gildas Gâteblé, Gabrielle Barriera, and Silvio Fici. Apocynaceae pro parte, Phellinaceae, Capparaceae : Flore de la Nouvelle Calédonie, volume 27. Publications scientifiques du Muséum, Paris ; IRD, Marseille, 2020. http://dx.doi.org/10.5852/fft49.

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L’exceptionnelle richesse floristique de la Nouvelle-Calédonie est mondialement connue. Plus de 3 400 espèces de plantes vasculaires indigènes y sont répertoriées, dont les trois-quarts sont endémiques de l’archipel. L’endémisme ne concerne pas seulement les espèces, mais aussi les genres (près d’une centaine) et même trois familles. La diversité se décline aussi sur le plan écologique, en lien avec l’histoire géologique originale de la Nouvelle-Calédonie, qui a favorisé le micro-endémisme et les espèces inféodées aux substrats ultramafiques. De nouvelles espèces continuent à être découvertes, aussi reste-t-il nécessaire de poursuivre prospections et recherches botaniques, afin de mieux comprendre l’origine et l’évolution de cette flore, et contribuer à sa préservation. Le présent volume regroupe trois familles d’Angiospermes. Celle des Apocynaceae dont la classification a été profondément remaniée depuis la publication en 1981 du fascicule « Apocynaceae », volume 10 de la Flore de la Nouvelle-Calédonie et Dépendances : les trois sous-familles traitées ici (Periplocoideae, Secamonoideae et Asclepiadoideae) formaient auparavant la famille des Asclepiadaceae. Les Phellinaceae qui, avec 10 espèces ligneuses, constituent l’une des trois familles endémiques du territoire. Enfin, la Nouvelle-Calédonie héberge quelques espèces de la famille cosmopolite des Capparaceae, toutes appartenant au genre du câprier (Capparis). Conformément à la ligne éditoriale de la collection, cet ouvrage comporte, pour chaque famille traitée indépendamment : une présentation générale suivie de descriptions détaillées des genres et des espèces ; des clés d’identification, en français et en anglais ; une illustration variée comprenant des dessins au trait et des photographies des plantes vivantes ; des cartes de répartition et une évaluation des besoins de conservation selon les critères de l’UICN.

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Book chapters on the topic "T cell diversity"

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Gustafson, Claire E., David L. Lamar, Cornelia M. Weyand, and Jörg J. Goronzy. "Age, T Cell Homeostasis, and T Cell Diversity in Humans." In Handbook of Immunosenescence, 303–22. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-99375-1_9.

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Gustafson, Claire E., David L. Lamar, Cornelia M. Weyand, and Jörg J. Goronzy. "Age, T Cell Homeostasis, and T Cell Diversity in Humans." In Handbook of Immunosenescence, 1–20. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64597-1_9-1.

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Purushe, Janaki, and Yi Zhang. "Histone Methyltransferases and T Cell Heterogeneity." In Signaling Mechanisms Regulating T Cell Diversity and Function, 203–29. Boca Raton : Taylor & Francis, 2017.: CRC Press, 2017. http://dx.doi.org/10.1201/9781315371689-11.

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O’Boyle, Kaitlin C., Takuya Ohtani, Sasikanth Manne, Bertram Bengsch, Sarah E. Henrickson, E. John Wherry, and Cecile Alanio. "Exploration of T-Cell Diversity Using Mass Cytometry." In Methods in Molecular Biology, 1–20. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0266-9_1.

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Cho, Jonathan J., Kyle J. Lorentsen, and Dorina Avram. "Models of Regulatory T Cell Alterations and Systemic Autoimmunity." In Signaling Mechanisms Regulating T Cell Diversity and Function, 231–48. Boca Raton : Taylor & Francis, 2017.: CRC Press, 2017. http://dx.doi.org/10.1201/9781315371689-12.

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Charbonnier, Louis-Marie, and Talal A. Chatila. "Phenotypic and Functional Characterization of Regulatory T Cell Populations." In Signaling Mechanisms Regulating T Cell Diversity and Function, 105–18. Boca Raton : Taylor & Francis, 2017.: CRC Press, 2017. http://dx.doi.org/10.1201/9781315371689-7.

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Fahl, Shawn P., Dietmar J. Kappes, and David L. Wiest. "TCR Signaling Circuits in αβ/γδ T Lineage Choice." In Signaling Mechanisms Regulating T Cell Diversity and Function, 85–104. Boca Raton : Taylor & Francis, 2017.: CRC Press, 2017. http://dx.doi.org/10.1201/9781315371689-6.

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Heller, Nicola M., Rosa Berga-Bolanos, Lynette Naler, and Jyoti Misra Sen. "Natural Killer T (NKT) Cells in Mice and Men." In Signaling Mechanisms Regulating T Cell Diversity and Function, 119–46. Boca Raton : Taylor & Francis, 2017.: CRC Press, 2017. http://dx.doi.org/10.1201/9781315371689-8.

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Barnett, John B. "Consequences of Blocking the Choreography of Double Negative Thymocyte Maturation." In Signaling Mechanisms Regulating T Cell Diversity and Function, 1–16. Boca Raton : Taylor & Francis, 2017.: CRC Press, 2017. http://dx.doi.org/10.1201/9781315371689-1.

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Samakai, Elsie, Christina Go, and Jonathan Soboloff. "Defining the Roles of Ca2+ Signals during T Cell Activation." In Signaling Mechanisms Regulating T Cell Diversity and Function, 177–202. Boca Raton : Taylor & Francis, 2017.: CRC Press, 2017. http://dx.doi.org/10.1201/9781315371689-10.

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Conference papers on the topic "T cell diversity"

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Grinshpun, Boris, Jennifer Sims, Peter Canoll, Jeffrey N. Bruce, Peter Sims, and Yufeng Shen. "Analyzing T cell repertoire diversity by high-throughput sequencing." In 2013 IEEE Global Conference on Signal and Information Processing (GlobalSIP). IEEE, 2013. http://dx.doi.org/10.1109/globalsip.2013.6736810.

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Baracho, Gisele V., Stephanie Widmann, and Aaron Tyznik. "Abstract 1815: Defining cell population diversity and T cell dysfunction in a mouse model of obesity." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1815.

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Patel, Preeyam, Marcos Iglesias, Qin Tang, Megan Biller, Alireza Alavi, and Ayako Pedersen. "1029 T cell receptor diversity analysis ofin vitro-expanded T cells against IDO1 and PD-L1-derived peptides." In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.1029.

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Yuguo, Song, Xiang Lei, and Bi Shengli. "Analysis of T cell receptor V beta diversity in peripheral CD8(+) T lymphocytes in patients with hepatitis B infection." In 2011 International Conference on Human Health and Biomedical Engineering (HHBE). IEEE, 2011. http://dx.doi.org/10.1109/hhbe.2011.6027968.

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ISHIDA, Y. "A STABILITY AND DIVERSITY ANALYSIS ON A MATHEMATICAL MODEL OF THE INTERACTION BETWEEN HIV AND T-CELL CD4+." In Proceedings of the Fourth Asian Symposium (ASCM 2000). WORLD SCIENTIFIC, 2000. http://dx.doi.org/10.1142/9789812791962_0036.

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Fan, Li, Angelo Harris, Patrick Franken, Matthew Loya, Gabrielle Suppa, Nora Pencheva, Susan Sun, et al. "80 Association ofin situT-cell receptor diversity and tumor adjacent immune cells to checkpoint inhibitor response in head and neck squamous cell carcinoma (HNSCC)." In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.0080.

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Choudhury, Noura, Kai Lee Yap, Kazuma Kiyotani, Poh Yin Yew, Alexa Campanile, Tatjana Antic, Gary Steinberg, Jae-Hyun Park, Peter H. O'Donnell, and Yusuke Nakamura. "Abstract 4899: Tumor T-cell receptor (TCR) diversity elucidates the immune response to genetic alterations of muscle-invasive bladder cancer." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-4899.

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Gu, Chenyi, Kenichi Shimada, Lukas Kania, Daniel E. Michaud, Madeline G. Townsend, and Jennifer L. Guerriero. "499 Myeloid diversity in hormone receptor positive breast cancer reveals myeloid and lymphoid signaling pathways that correlate with T cell inhibition." In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.0499.

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Shu, Tong, Hong Zheng, Yunong Gao, Min Gao, Zhipeng Zhou, and Jing Bai. "EP285/#110 Circulating T-cell receptor diversity as prognostic biomarker for PARP inhibitors maintenance therapy in high-grade serous ovarian cancer." In IGCS 2022 Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/ijgc-2022-igcs.376.

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Mackay, Sean, Jon Chen, Jeremy Patino, Y. David Seo, Seth Pollack, and Jing Zhou. "Abstract LB-190: Single-cell polyfunctionality of circulating CD4+ T cells correlates with T cell receptor repertoire diversity of PBMCs, indicating potential synergistic activity and peripheral biomarker predictive of efficacy of intratumor injection of the toll-like receptor 4 agonist G100." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-lb-190.

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Reports on the topic "T cell diversity"

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Fahima, Tzion, and Jorge Dubcovsky. Map-based cloning of the novel stripe rust resistance gene YrG303 and its use to engineer 1B chromosome with multiple beneficial traits. United States Department of Agriculture, January 2013. http://dx.doi.org/10.32747/2013.7598147.bard.

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Abstract:

Research problem: Bread wheat (Triticumaestivum) provides approximately 20% of the calories and proteins consumed by humankind. As the world population continues to increase, it is necessary to improve wheat yields, increase grain quality, and minimize the losses produced by biotic and abiotic stresses. Stripe rust, caused by Pucciniastriiformisf. sp. tritici(Pst), is one of the most destructive diseases of wheat. The new pathogen races are more virulent and aggressive than previous ones and have produced large economic losses. A rich source for stripe-rust resistance genes (Yr) was found in wild emmer wheat populations from Israel. Original Project goals: Our long term goal is to identify, map, clone, characterize and deploy in breeding, novel wild emmer Yr genes, and combine them with multiple beneficial traits. The current study was aiming to map and clone YrG303 and Yr15, located on chromosome 1BS and combine them with drought resistance and grain quality genes. Positional cloning of YrG303/Yr15: Fine mapping of these genes revealed that YrG303 is actually allelic to Yr15. Fine genetic mapping using large segregating populations resulted in reduction of the genetic interval spanning Yr15 to less than 0.1 cM. Physical mapping of the YrG303/Yr15 locus was based on the complete chromosome 1BS physical map of wheat constructed by our group. Screening of 1BS BAC library with Yr15 markers revealed a long BAC scaffold covering the target region. The screening of T. dicoccoidesaccession-specific BAC library with Yr15 markers resulted in direct landing on the target site. Sequencing of T. dicoccoidesBAC clones that cover the YrG303/Yr15 locus revealed a single candidate gene (CG) with conserved domains that may indicate a role in disease resistance response. Validation of the CG was carried out using EMS mutagenesis (loss-of- function approach). Sequencing of the CG in susceptible yr15/yrG303 plants revealed three independent mutants that harbour non-functional yr15/yrG303 alleles within the CG conserved domains, and therefore validated its function as a Pstresistance gene. Evaluation of marker-assisted-selection (MAS) for Yr15. Introgressions of Yr15 into cultivated wheat are widely used now. Recently, we have shown that DNA markers linked to Yr15 can be used as efficient tools for introgression of Yr15 into cultivated wheat via MAS. The developed markers were consistent and polymorphic in all 34 tested introgressions and are the most recommended markers for the introgression of Yr15. These markers will facilitate simultaneous selection for multiple Yr genes and help to avoid escapees during the selection process. Engineering of improved chromosome 1BS that harbors multiple beneficial traits. We have implemented the knowledge and genetic resources accumulated in this project for the engineering of 1B "super-chromosome" that harbors multiple beneficial traits. We completed the generation of a chromosome including the rye 1RS distal segment associated with improved drought tolerance with the Yr gene, Yr15, and the strong gluten allele 7Bx-over-expressor (7Bxᴼᴱ). We have completed the introgression of this improved chromosome into our recently released variety Patwin-515HP and our rain fed variety Kern, as well as to our top breeding lines UC1767 and UC1745. Elucidating the mechanism of resistance exhibited by Yr36 (WKS1). The WHEAT KINASE START1 (WKS1) resistance gene (Yr36) confers partial resistance to Pst. We have shown that wheat plants transformed with WKS1 transcript are resistant to Pst. WKS1 is targeted to the chloroplast where it phosphorylates the thylakoid-associatedascorbateperoxidase (tAPX) and reduces its ability to detoxify peroxides. Based on these results, we propose that the phosphorylation of tAPX by WKS1 reduces the ability of the cells to detoxify ROS and contributes to cell death. Distribution and diversity of WKS in wild emmer populations. We have shown that WKS1 is present only in the southern distribution range of wild emmer in the Fertile Crescent. Sequence analysis revealed a high level of WKS1 conservation among wild emmer populations, in contrast to the high level of diversity observed in NB-LRR genes. This phenomenon shed some light on the evolution of genes that confer partial resistance to Pst. Three new WKS1 haplotypes displayed a resistance response, suggesting that they can be useful to improve wheat resistance to Pst. In summary, we have improved our understanding of cereals’ resistance mechanisms to rusts and we have used that knowledge to develop improved wheat varieties.

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