Journal articles: 'Systems physiology'

1

Kuepfer, Lars. "Towards whole‐body systems physiology." Molecular Systems Biology 6, no. 1 (January 2010): 409. http://dx.doi.org/10.1038/msb.2010.70.

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ZARET, B. "Topics in integrated systems physiology." Journal of Nuclear Cardiology 7, no. 5 (September 2000): 405. http://dx.doi.org/10.1067/mnc.2000.109798.

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Petersen, O. H., and C. Bear. "Physiology: Two glucagon transducing systems." Nature 323, no. 6083 (September 1986): 18. http://dx.doi.org/10.1038/323018a0.

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Land, Michael F. "Comparative Physiology of Sensory Systems." Trends in Neurosciences 8 (January 1985): 372—IN8. http://dx.doi.org/10.1016/0166-2236(85)90133-x.

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Šrobár, Fedor. "Fröhlich Systems in Cellular Physiology." Prague Medical Report 113, no. 2 (2012): 95–104. http://dx.doi.org/10.14712/23362936.2015.25.

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Electromagnetic fields are usually absent in the picture of processes taking place in living cells which is dominated by biochemistry, molecular genetics and microscopic morphology. Yet experimental and theoretical studies suggest that this omission is not justified. At the end of 1960’s H. Fröhlich elaborated a semi-phenomenological model of polar oscillating units that are metabolically driven, exchange energy with the cell’s internal heat reservoir, and store part of the energy in excited vibrational modes in such way, that mode with the lowest frequency becomes highly excited, while the higher-order modes remain near thermal equilibrium. This affords energy-hungry chemical reactions to take place while the rest of the cell is not exposed to heat stress. At present, part of the cytoskeleton – microtubules – are deemed to fulfil the role of oscillating units. The paper provides an introduction to the Fröhlich ideas for readers with background in medicine and biology in that it avoids mathematical formulas and relies on figures to convey information about the basic properties of the model. The essential features of the Fröhlich model – most notably the energy condensation – are demonstrated on ensemble encompassing three coupled vibration modes that can be exactly described using original diagrammatic method.

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Sherman, Arthur. "Dynamical systems theory in physiology." Journal of General Physiology 138, no. 1 (June 27, 2011): 13–19. http://dx.doi.org/10.1085/jgp.201110668.

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Randall Thomas, S. "Kidney modeling and systems physiology." Wiley Interdisciplinary Reviews: Systems Biology and Medicine 1, no. 2 (September 2009): 172–90. http://dx.doi.org/10.1002/wsbm.14.

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Paul, Martin, Ali Poyan Mehr, and Reinhold Kreutz. "Physiology of Local Renin-Angiotensin Systems." Physiological Reviews 86, no. 3 (July 2006): 747–803. http://dx.doi.org/10.1152/physrev.00036.2005.

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Since the first identification of renin by Tigerstedt and Bergmann in 1898, the renin-angiotensin system (RAS) has been extensively studied. The current view of the system is characterized by an increased complexity, as evidenced by the discovery of new functional components and pathways of the RAS. In recent years, the pathophysiological implications of the system have been the main focus of attention, and inhibitors of the RAS such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin (ANG) II receptor blockers have become important clinical tools in the treatment of cardiovascular and renal diseases such as hypertension, heart failure, and diabetic nephropathy. Nevertheless, the tissue RAS also plays an important role in mediating diverse physiological functions. These focus not only on the classical actions of ANG on the cardiovascular system, namely, the maintenance of cardiovascular homeostasis, but also on other functions. Recently, the research efforts studying these noncardiovascular effects of the RAS have intensified, and a large body of data are now available to support the existence of numerous organ-based RAS exerting diverse physiological effects. ANG II has direct effects at the cellular level and can influence, for example, cell growth and differentiation, but also may play a role as a mediator of apoptosis. These universal paracrine and autocrine actions may be important in many organ systems and can mediate important physiological stimuli. Transgenic overexpression and knock-out strategies of RAS genes in animals have also shown a central functional role of the RAS in prenatal development. Taken together, these findings may become increasingly important in the study of organ physiology but also for a fresh look at the implications of these findings for organ pathophysiology.

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Weyers, Marc H. "Vertebrate circadian systems. Structure and physiology." Behavioural Processes 11, no. 3 (August 1985): 333–34. http://dx.doi.org/10.1016/0376-6357(85)90032-4.

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10

Joyner, Michael J., and Bengt Saltin. "Exercise physiology and human performance: systems biology before systems biology!" Journal of Physiology 586, no. 1 (January 1, 2008): 9. http://dx.doi.org/10.1113/jphysiol.2007.148411.

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Stickney, Robert R. "Physiology of Fish in Intensive Culture Systems." Progressive Fish-Culturist 60, no. 1 (January 1998): 73–75. http://dx.doi.org/10.1577/1548-8640(1998)060<0072:>2.0.co;2.

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Karasov, William H., Carlos Martínez del Rio, and Enrique Caviedes-Vidal. "Ecological Physiology of Diet and Digestive Systems." Annual Review of Physiology 73, no. 1 (March 17, 2011): 69–93. http://dx.doi.org/10.1146/annurev-physiol-012110-142152.

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RHEE, KENNETH J., JAMES R. MACKENZIE, RICHARD E. BURNEY, NEIL H. WILLITS, ROBERT J. OʼMALLEY, NANCY REID, DANIEL SCHWABE, DANIEL L. STORER, and RITA WEBER. "Rapid acute physiology scoring in transport systems." Critical Care Medicine 18, no. 10 (October 1990): 1119–23. http://dx.doi.org/10.1097/00003246-199010000-00013.

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Bartsch, Ronny P., Kang K. L. Liu, Amir Bashan, and Plamen Ch Ivanov. "Network Physiology: How Organ Systems Dynamically Interact." PLOS ONE 10, no. 11 (November 10, 2015): e0142143. http://dx.doi.org/10.1371/journal.pone.0142143.

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15

Van Der Horst, Dick J. "Insects as Model Systems for Animal Physiology." Netherlands Journal of Zoology 44, no. 1-2 (1993): 130–38. http://dx.doi.org/10.1163/156854294x00105.

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16

Kersten, Sander. "Integrated physiology and systems biology of PPARα." Molecular Metabolism 3, no. 4 (July 2014): 354–71. http://dx.doi.org/10.1016/j.molmet.2014.02.002.

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17

van den Beld, Annewieke W., Jean-Marc Kaufman, M. Carola Zillikens, Steven W. J. Lamberts, Josephine M. Egan, and Aart J. van der Lely. "The physiology of endocrine systems with ageing." Lancet Diabetes & Endocrinology 6, no. 8 (August 2018): 647–58. http://dx.doi.org/10.1016/s2213-8587(18)30026-3.

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18

Netter, K. J. "Vanadium in biological systems, physiology and biochemistry." Toxicology 67, no. 3 (March 1991): 351–52. http://dx.doi.org/10.1016/0300-483x(91)90033-w.

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19

Wegener, G. "Flying insects: model systems in exercise physiology." Experientia 52, no. 5 (May 1996): 404–12. http://dx.doi.org/10.1007/bf01919307.

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20

Blair, K. L., and P. A. V. Anderson. "Physiology and pharmacology of turbellarian neuromuscular systems." Parasitology 113, S1 (January 1996): S73—S82. http://dx.doi.org/10.1017/s0031182000077908.

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SUMMARYOur understanding of the neurobiology of the Platyhelminthes has come in large part from free-living turbellarians. In addition to providing considerable information about the capabilities of the rudimentary nervous system present in all members of the phylum, turbellarians have provided the most definitive information about the variety of ion channels present in the membranes of neurones and muscle cells, and about the physiology and pharmacology of those channels. Furthermore, preparations of single, viable muscle cells have provided some of the most conclusive evidence about the variety of transmitters present, and the types of response they evoke. Here, we review what is known about the physiology and pharmacology of the turbellarian neuromuscular system. Particular attention is given to the triclad flatworm Bdelloura Candida, the best studied species in this respect, but other species are included where relevant.

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21

An, Olga, Alexey Martyanov, and Mikhail Panteleev. "Immune thrombocytopenia: what can the systems biology and systems physiology offer?" Systems Biology and Physiology Reports 1, no. 4 (December 2021): 1–9. http://dx.doi.org/10.52455/sbpr.01.202104011.

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22

Buckley, Sarah J. "Executive Summary of Hormonal Physiology of Childbearing: Evidence and Implications for Women, Babies, and Maternity Care." Journal of Perinatal Education 24, no. 3 (2015): 145–53. http://dx.doi.org/10.1891/1058-1243.24.3.145.

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ABSTRACTThis report synthesizes evidence about innate hormonally mediated physiologic processes in women and fetuses/newborns during childbearing, and possible impacts of common maternity care practices and interventions on these processes, focusing on four hormone systems that are consequential for childbearing. Core hormonal physiology principles reveal profound interconnections between mothers and babies, among hormone systems, and from pregnancy through to the postpartum and newborn periods. Overall, consistent and coherent evidence from physiologic understandings and human and animal studies finds that the innate hormonal physiology of childbearing has significant benefits for mothers and babies. Such hormonally-mediated benefits may extend into the future through optimization of breastfeeding and maternal-infant attachment. A growing body of research finds that common maternity care interventions may disturb hormonal processes, reduce their benefits, and create new challenges. Developmental and epigenetic effects are biologically plausible but poorly studied. The perspective of hormonal physiology adds new considerations for benefit-harm assessments in maternity care, and suggests new research priorities, including consistently measuring crucial hormonally mediated outcomes that are frequently overlooked. Current understanding suggests that safely avoiding unneeded maternity care interventions would be wise, as supported by the Precautionary Principle. Promoting, supporting, and protecting physiologic childbearing, as far as safely possible in each situation, is a low-technology health and wellness approach to the care of childbearing women and their fetuses/newborns that is applicable in almost all maternity care settings.

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23

Greenhaff, Paul L., and Mark Hargreaves. "‘Systems biology’ in human exercise physiology: is it something different from integrative physiology?" Journal of Physiology 589, no. 5 (February 25, 2011): 1031–36. http://dx.doi.org/10.1113/jphysiol.2010.201525.

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24

Amann, Markus. "Commentaries on Viewpoint: Fatigue mechanisms determining exercise performance: Integrative physiology is systems physiology." Journal of Applied Physiology 104, no. 5 (May 2008): 1543–46. http://dx.doi.org/10.1152/japplphysiol.90427.2008.

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25

Kibble, Jonathan D. "Using the physiology of normal aging as a capstone integration exercise in a medical physiology course." Advances in Physiology Education 45, no. 2 (June 2021): 365–68. http://dx.doi.org/10.1152/advan.00020.2021.

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As the Baby Boomer generation reaches old age, there has been a significant increase in the number of older adults needing healthcare over the past decade. The physiology of aging is therefore a highly relevant topic for the preclinical medical curriculum. I describe a new capstone unit on the physiology of aging, placed at the end a medical physiology course, to provide a vehicle for integration of prior learning about physiology of each individual body system. Students were provided with online self-study modules as preparation for a mandatory small group case-based learning activity. A detailed case of an elderly female patient being assessed for fall risk was provided. Students were required to document a “Review of Systems” predicting decreased system functions due to senescence and to prepare a group concept map illustrating how physiologic deficits contributed to fall risk in the patient. Students successfully completed the activity and reported generally good satisfaction with the experience. The activity was judged an effective tool for students to consolidate prior learning and to apply physiology to an important medical topic. The lesson also provided several opportunities for curriculum integration with cell biology, biochemistry, anatomy, and clinical skills components.

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26

Mingarelli, Maurizio. "The cardiovascular system renal regulation." Nephrology @ Point of Care 2, no. 1 (January 2016): pocj.5000201. http://dx.doi.org/10.5301/pocj.5000201.

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The study of kidney physiology and cardiovascular system physiology has long unveiled several points of contract from which the existence of integrated mechanisms between the two systems has readily been inferred. In conclusion, the need is felt to conduct new studies to explore how the physiologic response to neuro-vegetative stimuli correlates to the renal function level indicated by the glomerular filtration rate (GFR) in a view to demonstrating that a decreased GFR results in cardiovascular alterations whose size is directly proportional to the same GFR reduction.

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27

Segal, Steven S., Pope L. Moseley, Thomas J. Doubt, Brian R. Duling, Susan C. Kandarian, and Charlotte A. Tate. "MOLECULAR BIOLOGY AND SYSTEMS PHYSIOLOGY: BUILDING THE BRIDGE2." Medicine &amp Science in Sports &amp Exercise 28, Supplement (May 1996): 1. http://dx.doi.org/10.1097/00005768-199605001-00002.

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28

Sieck, Gary C. "Physiology in Perspective: Physiological Systems Respond to Time." Physiology 35, no. 2 (March 1, 2020): 84–85. http://dx.doi.org/10.1152/physiol.00002.2020.

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29

Pandey, Abhay Kumar, and Garima Pandey. "Epigenetics and Systems Physiology of Nutrition: An Overview." Advances in Diabetes and Metabolism 5, no. 1 (January 2017): 6–11. http://dx.doi.org/10.13189/adm.2017.050102.

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30

Wegener, N., and M. Koch. "Neurobiology and Systems Physiology of the Endocannabinoid System." Pharmacopsychiatry 42, S 01 (May 2009): S79—S86. http://dx.doi.org/10.1055/s-0029-1216346.

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31

Bourne, George B., and Brian R. McMahon. "The Physiology of Invertebrate Circulatory Systems: An Introduction." Physiological Zoology 63, no. 1 (January 1990): 1–2. http://dx.doi.org/10.1086/physzool.63.1.30158150.

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32

Matthews, Joseph I., Bruce A. Bush, and Freddie M. Morales. "Microprocessor Exercise Physiology Systems vs a Nonautomated System." Chest 92, no. 4 (October 1987): 696–703. http://dx.doi.org/10.1378/chest.92.4.696.

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33

Sung, Jong Hwan, Jamin Koo, and Michael L. Shuler. "Mimicking the Human Physiology with Microphysiological Systems (MPS)." BioChip Journal 13, no. 2 (June 2019): 115–26. http://dx.doi.org/10.1007/s13206-019-3201-z.

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34

Peter, Christian, and Antje Herbon. "Emotion representation and physiology assignments in digital systems." Interacting with Computers 18, no. 2 (March 2006): 139–70. http://dx.doi.org/10.1016/j.intcom.2005.10.006.

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35

Lyons, Declan G., and Jason Rihel. "Sleep circuits and physiology in non-mammalian systems." Current Opinion in Physiology 15 (June 2020): 245–55. http://dx.doi.org/10.1016/j.cophys.2020.03.006.

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36

Natochin, Juri V. "Philosophy of Physiology." Voprosy Filosofii, no. 12 (2022): 17–27. http://dx.doi.org/10.21146/0042-8744-2022-12-17-27.

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The article deals with the key issues of philosophy in physiology, one of the basic sciences of natural science. The problem of the particular and the general is discussed using the example of the ratio of individual cells, organs in the formation of the functions of an integral organism; the relevance of the individual is especially significant in the current trend towards the analysis of huge data sets (big data). The criterion of complexity is analyzed by comparing individuals performing physiological functions, from unicellular organisms to huge animals. The similarity of the morpho-functional organization of objects in physiology, linguistics, computer science, technical systems has been revealed. In the evolution of living organisms, an internal environment was formed in which cells live. Physiological systems provide homeostasis – the constancy of the physical and chemical parameters of the fluids of the internal environment, which requires a philosophical understanding of the standard in living organisms in comparison with the physical constants of the surrounding world. The question of personal freedom in its physiological understanding is discussed. The philosophical problem is analyzed, why everything happens the way it is and not otherwise. The conclusion is devoted to the relationship between reason and feelings in their philosophical and physiological senses.

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37

Caplan, Michael. "Systems Biology and the Biology of Systems." Physiology 25, no. 2 (April 2010): 58. http://dx.doi.org/10.1152/physiol.00010.2010.

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38

Dover, M., Wael Tawfick, Niamh Hynes, and Sherif Sultan. "Evaluation of illness severity scoring systems and risk prediction in vascular intensive care admissions." Vascular 24, no. 4 (July 10, 2016): 390–403. http://dx.doi.org/10.1177/1708538115604089.

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IntroductionThis study examines the predictive value of intensive care unit (ICU) scoring systems in a vascular ICU population.MethodsFrom April 2005 to September 2011, we examined 363 consecutive ICU admissions. Simplified Acute Physiology Score II (SAPS II), Acute Physiology and Chronic Health Evaluation II (APACHE II), APACHE IV, Multiple Organ Dysfunction Score (MODS), organ dysfunctions and/or infection (ODIN), mortality prediction model (MPM) and physiologic and operative severity score for the enumeration of mortality and morbidity (POSSUM) were calculated. The Glasgow Aneurysm Score (GAS) was calculated for patients with aneurysm-related admissions.ResultsOverall mortality for complex vascular intervention was 11.6%. At admission, the areas under the receiver operating characteristic curve (AUCs) was 0.884 for SAPS II, 0.894 for APACHE II, 0.895 for APACHE IV, 0.902 for MODS, 0.891 for ODIN and 0.903 for MPM. At 24 h, model discrimination was best for POSSUM (AUC = 0.906) and MPM (AUC = 0.912).ConclusionThe good discrimination of these scoring systems indicates their value as an adjunct to clinical assessment but should not be used on an individual basis as a clinical decision-making tool.

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39

Kremers, Jan, and Barry B. Lee. "Comparative retinal physiology in anthropoids." Vision Research 38, no. 21 (November 1998): 3339–44. http://dx.doi.org/10.1016/s0042-6989(97)00343-x.

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40

Gavaghan, David, Alan Garny, Philip K. Maini, and Peter Kohl. "Mathematical models in physiology." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 364, no. 1842 (March 22, 2006): 1099–106. http://dx.doi.org/10.1098/rsta.2006.1757.

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Computational modelling of biological processes and systems has witnessed a remarkable development in recent years. The search-term ( modelling OR modeling ) yields over 58 000 entries in PubMed, with more than 34 000 since the year 2000: thus, almost two-thirds of papers appeared in the last 5–6 years, compared to only about one-third in the preceding 5–6 decades. The development is fuelled both by the continuously improving tools and techniques available for bio-mathematical modelling and by the increasing demand in quantitative assessment of element inter-relations in complex biological systems. This has given rise to a worldwide public domain effort to build a computational framework that provides a comprehensive theoretical representation of integrated biological function—the Physiome. The current and next issues of this journal are devoted to a small sub-set of this initiative and address biocomputation and modelling in physiology, illustrating the breadth and depth of experimental data-based model development in biological research from sub-cellular events to whole organ simulations.

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41

Kuster, Diederik W. D., Daphne Merkus, Jolanda van der Velden, Adrie J. M. Verhoeven, and Dirk J. Duncker. "‘Integrative Physiology 2.0’: integration of systems biology into physiology and its application to cardiovascular homeostasis." Journal of Physiology 589, no. 5 (February 25, 2011): 1037–45. http://dx.doi.org/10.1113/jphysiol.2010.201533.

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42

Weston, David J., Paul J. Hanson, Richard J. Norby, Gerald A. Tuskan, and Stan D. Wullschleger. "From systems biology to photosynthesis and whole-plant physiology." Plant Signaling & Behavior 7, no. 2 (February 2012): 260–62. http://dx.doi.org/10.4161/psb.18802.

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43

de Graaf, Albert A., Andreas P. Freidig, Baukje De Roos, Neema Jamshidi, Matthias Heinemann, Johan A. C. Rullmann, Kevin D. Hall, Martin Adiels, and Ben van Ommen. "Nutritional Systems Biology Modeling: From Molecular Mechanisms to Physiology." PLoS Computational Biology 5, no. 11 (November 26, 2009): e1000554. http://dx.doi.org/10.1371/journal.pcbi.1000554.

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44

Loor, Juan J., Massimo Bionaz, and James K. Drackley. "Systems Physiology in Dairy Cattle: Nutritional Genomics and Beyond." Annual Review of Animal Biosciences 1, no. 1 (January 2013): 365–92. http://dx.doi.org/10.1146/annurev-animal-031412-103728.

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45

Mo, Monica L., and Bernhard Ø. Palsson. "Understanding human metabolic physiology: a genome-to-systems approach." Trends in Biotechnology 27, no. 1 (January 2009): 37–44. http://dx.doi.org/10.1016/j.tibtech.2008.09.007.

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46

Bova, Toree L., Ludovica Chiavaccini, Garrett F. Cline, Caitlin G. Hart, Kelli Matheny, Ashleigh M. Muth, Benjamin E. Voelz, Darrel Kesler, and Erdoğan Memili. "Environmental stressors influencing hormones and systems physiology in cattle." Reproductive Biology and Endocrinology 12, no. 1 (2014): 58. http://dx.doi.org/10.1186/1477-7827-12-58.

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47

Iranzo Lobera, Carlos S. "Comments on the Physiology of Single-Ossicle Transmission Systems." Acta Otorrinolaringologica (English Edition) 59, no. 2 (January 2008): 87. http://dx.doi.org/10.1016/s2173-5735(08)70198-4.

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48

Fraser, H. M. "9 LHRH analogues: their clinical physiology and delivery systems." Baillière's Clinical Obstetrics and Gynaecology 2, no. 3 (September 1988): 639–58. http://dx.doi.org/10.1016/s0950-3552(88)80050-6.

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49

Morris, Andrew R., Daniel L. Stanton, Destino Roman, and Andrew C. Liu. "Systems Level Understanding of Circadian Integration with Cell Physiology." Journal of Molecular Biology 432, no. 12 (May 2020): 3547–64. http://dx.doi.org/10.1016/j.jmb.2020.02.002.

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50

Souza, Gustavo M., Tony Trewavas, and Danilo de Menezes Daloso. "Systems plant physiology: An integrated view of plants life." Progress in Biophysics and Molecular Biology 146 (September 2019): 1–2. http://dx.doi.org/10.1016/j.pbiomolbio.2019.06.005.

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Journal articles on the topic 'Systems physiology'

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