Academic literature on the topic 'Systems biology investigation'
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Journal articles on the topic "Systems biology investigation"
Fernandes, Marco, and Holger Husi. "Integrative Systems Biology Investigation of Fabry Disease." Diseases 4, no. 4 (November 15, 2016): 35. http://dx.doi.org/10.3390/diseases4040035.
Full textKing, Ross D., Maria Liakata, Chuan Lu, Stephen G. Oliver, and Larisa N. Soldatova. "On the formalization and reuse of scientific research." Journal of The Royal Society Interface 8, no. 63 (April 13, 2011): 1440–48. http://dx.doi.org/10.1098/rsif.2011.0029.
Full textSmith, Maren L., and Mark P. Styczynski. "Systems Biology-Based Investigation of Host–Plasmodium Interactions." Trends in Parasitology 34, no. 7 (July 2018): 617–32. http://dx.doi.org/10.1016/j.pt.2018.04.003.
Full textZou, Jun, Ming-Wu Zheng, Gen Li, and Zhi-Guang Su. "Advanced Systems Biology Methods in Drug Discovery and Translational Biomedicine." BioMed Research International 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/742835.
Full textHogstrand, C., T. S. Carroll, J. D. Rasinger, V. Reffatto, A. K. Lundebye, M. Haave, R. Tassinari, et al. "Systems biology investigation of the mechanisms of brominated flame retardant neurotoxicity." Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 157 (September 2010): S4. http://dx.doi.org/10.1016/j.cbpa.2010.06.009.
Full textPurohit, Vinee, Allon Wagner, Nir Yosef, and Vijay K. Kuchroo. "Systems-based approaches to study immunometabolism." Cellular & Molecular Immunology 19, no. 3 (February 4, 2022): 409–20. http://dx.doi.org/10.1038/s41423-021-00783-9.
Full textOri, Alessandro, Mark C. Wilkinson, and David G. Fernig. "A Systems Biology Approach for the Investigation of the Heparin/Heparan Sulfate Interactome." Journal of Biological Chemistry 286, no. 22 (March 30, 2011): 19892–904. http://dx.doi.org/10.1074/jbc.m111.228114.
Full textAsnaashari, Solmaz, Elham Amjad, and Babak Sokouti. "A comprehensive investigation on liver regeneration: a meta-analysis and systems biology approach." Clinical and Experimental Hepatology 7, no. 2 (2021): 183–90. http://dx.doi.org/10.5114/ceh.2021.107564.
Full textCaberlotto, Laura, and Thanh-Phuong Nguyen. "A systems biology investigation of neurodegenerative dementia reveals a pivotal role of autophagy." BMC Systems Biology 8, no. 1 (2014): 65. http://dx.doi.org/10.1186/1752-0509-8-65.
Full textFigeac, Nicolas, Malgorzata Daczewska, Christophe Marcelle, and Krzysztof Jagla. "Muscle stem cells and model systems for their investigation." Developmental Dynamics 236, no. 12 (2007): 3332–42. http://dx.doi.org/10.1002/dvdy.21345.
Full textDissertations / Theses on the topic "Systems biology investigation"
Gormley, Padhhraig J. "An investigation of advanced data-driven identification methods for systems biology." Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534735.
Full textGray, Kurtis N. "A Molecular Phylogeny of the Echeneoidea (Perciformes: Carangoidei) and an Investigation of Population Structuring Within the Echeneidae." W&M ScholarWorks, 2005. https://scholarworks.wm.edu/etd/1539617836.
Full textWang, Benjamin X. Ph D. Massachusetts Institute of Technology. "Investigation of two-component signaling systems in Pseudomonas aeruginosa and their roles in the mucus barrier." Thesis, Massachusetts Institute of Technology, 2021. https://hdl.handle.net/1721.1/130821.
Full textCataloged from the official PDF of thesis.
Includes bibliographical references.
All living things must be able to sense and respond to signals in their environment in order to grow and survive. For bacteria, a common means through which this occurs is via two-component signaling systems, which are typically comprised of a membrane-bound histidine kinase that senses external cues signals, and a cognate cytoplasmic response regulator that triggers changes in gene expression. The importance of these systems is highlighted by the fact that they have been identified in the vast majority of sequenced bacteria. However, despite their prevalence, much remains to be discovered about these sensory systems. In particular, both the actual processes that these systems control, along with the signals that they sense and respond to, remain poorly characterized in many cases.
In this work, I further characterize two-component signaling systems in the opportunistic pathogen Pseudomonas aeruginosa, which is most well-known for chronically infecting the lungs of patients with cystic fibrosis. I begin by screening a collection of in-frame deletion mutants of each histidine kinase in the PA14 strain against a dozen virulence-associated phenotypes, including different types of motility, biofilm formation, virulence factor production, and antibiotic resistance. Through this approach, I identify nearly two dozen of these proteins as important regulators of virulence. As P. aeruginosa is a human-associated mucosal pathogen, I next search for host-derived signals in mucus that act through these sensory systems in P. aeruginosa. I identify mucins and their associated glycans as signals that act through the RetS histidine kinase and the GacS-GacA two-component signaling system.
One major output of this signaling is the downregulation of the type VI secretion system, which suggests that mucin glycans may serve as host-derived "safety signals" that suppress microbial competition under non-dysbiotic conditions. Finally, I characterize the molecular mechanisms by which RetS inhibits GacS activity to better understand the unusual interactions between these two histidine kinases. Overall, this work underscores the diverse and important roles that two-component signaling systems play in bacteria, and begins to shed light on how microbes like P. aeruginosa utilize these systems to sense and respond to signals in the host.
by Benjamin X. Wang.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Biology
Dubaj, Vladimir, and n/a. "Novel optical fluorescence imaging probe for the investigation of biological function at the microscopic level." Swinburne University of Technology, 2005. http://adt.lib.swin.edu.au./public/adt-VSWT20060905.084615.
Full textPrice, Heather Leigh. "Investigation of larval sensory systems in the marine bryozoan, Bugula neritina." DigitalCommons@CalPoly, 2015. https://digitalcommons.calpoly.edu/theses/1410.
Full textHyder, Jennifer A. "An Investigation of the Effects of Increased Tidal Inundation, Competition, and Facilitation on Salt Marsh Systems." Thesis, University of South Florida, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3700275.
Full textThe low-lying topographic nature of salt marshes makes plants in these communities particularly vulnerable to increased salinity and inundation exposure associated with sea level rise. Both increased salinity and inundation have been cited as major causes of reduced plant performance and survival in marsh and areas fringing marsh. In addition to limitations imposed by physical stress, interspecific interactions have also been shown to mediate the performance and survival of salt marsh and salt marsh fringing species. The Stress Gradient Hypothesis (SGH) postulates that species interactions shift from competitive to facilitative as stress levels increase and predicts that (a) the frequency and intensity of facilitative interactions increase as conditions become more stressful for plants and (b) the strength of competitive interactions increases as abiotic stress levels diminish. The SGH has been rigorously tested to examine how both the frequency and intensity of species interactions change under varying physical stress levels. Studies conducted in salt marsh systems have shown facilitation to be as strong of a driving force as competition in influencing plant performance and survival and have shown that while competition appears to be the pervasive force in the less physically stressful terrestrial zones fringing salt marshes, facilitation influences the performance and survival of species in harsher marsh areas. Under conditions of sea level rise, it remains unclear if the nature of interspecific interactions would shift as stress levels change. This research endeavors to examine the interplay between abiotic stresses and biotic interactions under conditions of increased salinity and inundation exposure.
The first study presented here investigated the effects of increased inundation and soil salinity associated with sea level rise on four salt marsh fringing species, and assesses how competition and facilitation impact survival of salt marsh fringing plant survival under these changing conditions. All plant species experienced reduced growth and photosynthetic inhibition below their current distributional positions, both in the presence and absence of neighboring above ground vegetation. The findings also signal a potential shift in the nature of interspecific interactions from competition to facilitation to neutral as plants begin to experience increased salt and inundation exposure.
The second study aimed to disentangle the effects of increased soil salinity and increased soil moisture on four salt marsh fringing species, and to examine the effects of plant neighbors. The results showed that fringe plants exposed to increased inundation experienced a two-fold reduction in performance and survival over 750 g pure salt addition, suggesting that inundation may be a more important limiting factor than salinity with rising sea levels. Landward transplants at the forest-fringe margin exposed to lower soil salinity and decreased inundation exhibited a three-fold increase in performance and survival when compared to controls. Neighbor manipulation studies, which consisted of trimming neighboring vegetation to ground level, again suggested that interspecific interactions in salt marsh fringing species may shift from competitive to facilitative with climate-induced sea level rise. Overall, our findings suggest that salt marsh fringing species may not be able to tolerate changing conditions associated with sea level rise and their survival may hinge on their ability to migrate towards higher elevations.
The final experiment tested the Stress Gradient Hypothesis and investigated the relative importance of facilitation and competition in a salt marsh system under varying stress levels. This study also ascertained whether salt or inundation exposure is the primary influence on salt marsh plant performance and survival. As in previous studies, our findings suggest that many salt marsh plants don't require, but merely tolerate harsher abiotic conditions. The results showed that plants at higher elevations were depressed by strong competitive pressure from neighboring fringe species while plants at lower elevations benefited from the presence of neighbors. Collectively, the results of these studies indicate that species interactions are an integral driver of plant distribution in salt marsh communities. Furthermore, our findings indicate that changing stress levels may not always result in a shift in the nature of interspecific interactions. These studies have endeavored to show that the interplay between competition and facilitation interacts with physical processes to determine the growth and performance of both fringe and marsh plant species. The paucity of studies examining the roles of species interactions and changing abiotic stress levels on multiple salt marsh and salt marsh fringing species warrants the need for additional research. The responses of salt marsh and salt marsh fringing species to sea level rise can not only serve as very valuable and sensitive indictors of climate change, but will also aid in predicting the future location of the marsh-fringe-forest ecotone, which is predicted to shift inland as sea levels continue to rise.
Britton, Oliver Jonathan. "Combined experimental and computational investigation into inter-subject variability in cardiac electrophysiology." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:6299240d-0528-4662-8e1f-5025f39e730f.
Full textParikh, Jaimit B. "Theoretical Investigation of Intra- and Inter-cellular Spatiotemporal Calcium Patterns in Microcirculation." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/1927.
Full textChee, Meng May. "Investigations into telomere biology in systemic sclerosis." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3615/.
Full textWilcock, Paul. "A systems biology approach for investigating oral squamous cell carcinoma (OSCC)." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/a-systems-biology-approach-for-investigating-oral-squamous-cell-carcinoma-oscc(8ec3728b-1928-450f-b467-76996fa970fb).html.
Full textBooks on the topic "Systems biology investigation"
Winthrop University. Department of Biology, ed. Biology 151: Laboratory manual: investigations into living systems. Mason, OH: Cengage Learning, 2008.
Find full textThree-Dimensional Confocal Microscopy: Volume Investigation of Biological Specimens: Volume Investigation of Biological Specimens (Cell Biology). Academic Press, 1994.
Find full text(Editor), John K. Stevens, Linda R. Mills (Editor), Judy E. Trogadis (Editor), Dennis E. Buetow (Series Editor), Ian T. Cameron (Series Editor), G. M. Padilla (Series Editor), and A. M. Zimmerman (Series Editor), eds. Three-Dimensional Confocal Microscopy: Volume Investigation of Biological Specimens: Volume Investigation of Biological Specimens (Cell Biology). Academic Press, 1994.
Find full textThree-dimensional confocal microscopy: Volume investigation of biological specimens. San Diego: Academic Press, 1994.
Find full textBurton, Derek, and Margaret Burton. Essential Fish Biology. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198785552.001.0001.
Full textKaskel, Albert, Paul Jr Hummer, Raymond F. Oram, and James E. Kennedy. Laboratory Biology: Investigating Living Systems. Merrill Pub Co, 1999.
Find full textStudy, Biological Sciences Curriculum. Investigating Systems and Change. Kendall/Hunt Publishing Company, 1993.
Find full textKauffman, Stuart A. Investigations. Oxford University Press, USA, 2000.
Find full textKauffman, Stuart A. Investigations. Oxford University Press, 2000.
Find full textKauffman, Stuart A. Investigations. Oxford University Press, 2002.
Find full textBook chapters on the topic "Systems biology investigation"
Thomas-Vaslin, Véronique, Adrien Six, Bertrand Bellier, and David Klatzmann. "Lymphocyte Labeling, Cell Division Investigation." In Encyclopedia of Systems Biology, 1152–54. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_708.
Full textCong, Xiao, John W. Patrick, Yang Liu, Xiaowen Liang, Wen Liu, and Arthur Laganowsky. "Investigation of Protein–Lipid Interactions Using Native Mass." In Microbial Systems Biology, 41–64. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1585-0_3.
Full textRamji, Dipak P., Alaa Ismail, Jing Chen, Fahad Alradi, and Sulaiman Al Alawi. "Survey of Model Systems for Investigation of Key Associated with." In Methods in Molecular Biology, 39–56. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1924-7_3.
Full textDesoeuvres, Aurélien, Peter Szmolyan, and Ovidiu Radulescu. "Qualitative Dynamics of Chemical Reaction Networks: An Investigation Using Partial Tropical Equilibrations." In Computational Methods in Systems Biology, 61–85. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-15034-0_4.
Full textRamanathan, S., A. K. Wright, and G. W. Arbuthnott. "A Physiological Investigation of the Two Corticostriatal Systems in Rat Somatsensory Striatum." In Advances in Behavioral Biology, 389–97. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0715-4_39.
Full textRowden, Stephen J. L., Paolo Bombelli, and Christopher J. Howe. "Biophotovoltaics: Design and Study of Bioelectrochemical Systems for Biotechnological Applications and Metabolic Investigation." In Methods in Molecular Biology, 335–46. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7786-4_20.
Full textTraynard, Pauline, François Fages, and Sylvain Soliman. "Model-Based Investigation of the Effect of the Cell Cycle on the Circadian Clock Through Transcription Inhibition During Mitosis." In Computational Methods in Systems Biology, 208–21. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-23401-4_18.
Full textBersch, Beate, Matthew R. Groves, Johann P. Klare, Andrew E. Torda, and Darío Ortiz de Orué Lucana. "Applications of Structural Biology and Bioinformatics in the Investigation of Oxidative Stress-Related Processes." In Systems Biology of Free Radicals and Antioxidants, 505–34. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-30018-9_196.
Full textWang, Yu-Chao, and Bor-Sen Chen. "Network Biomarker Construction for Molecular Investigation and Diagnosis of Lung Cancer via Microarray Data." In A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems, 3–29. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-9047-5_1.
Full textKrishnan, J., and C. Liu. "An Investigation of Signal Transduction and Irreversible Decision Making Through Monostable and Bistable Switches." In A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems, 219–43. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-9047-5_9.
Full textConference papers on the topic "Systems biology investigation"
"The investigation of Poly(ADP-ribose)polymerase activity in the context of nucleosome." In SYSTEMS BIOLOGY AND BIOINFORMATICS. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 2019. http://dx.doi.org/10.18699/sbb-2019-20.
Full textGlier, Michael W., Daniel A. McAdams, and Julie S. Linsey. "An Experimental Investigation of Analogy Formation Using the Engineering-to-Biology Thesaurus." In ASME 2013 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/detc2013-13160.
Full text"Investigation of the role of alternative splicing." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-288.
Full text"Detection and investigation of genes with circadian expression pattern in common wheat." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-201.
Full text"Investigation of various hemodynamic regimes in elastic vessels." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-132.
Full textKozak, Maciej, Carlos Granja, Claude Leroy, and Ivan Stekl. "Small Angle X-ray Scattering in Structural Investigation of Selected Biological Systems." In Nuclear Physics Medthods and Accelerators in Biology and Medicine. AIP, 2007. http://dx.doi.org/10.1063/1.2825775.
Full textSehndkar C V, Mahadevappa M., Lenka P K, Kumar Ratnesh, and Biswas A. "Efficacy of FES for restoring hand grasp in hemiplegia: Investigation using biosignals." In 2016 International Conference on Systems in Medicine and Biology (ICSMB). IEEE, 2016. http://dx.doi.org/10.1109/icsmb.2016.7915074.
Full textEgan, Paul F., Jonathan Cagan, Christian Schunn, and Philip R. LeDuc. "Utilizing Emergent Levels to Facilitate Complex Systems Design: Demonstrated in a Synthetic Biology Domain." In ASME 2013 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/detc2013-12072.
Full textQureshi, T. R., C. R. Chatwin, Zhou Zhou, Nan Li, and W. Wang. "Investigation of voltage source design's for electrical impedance mammography (EIM) systems." In 2012 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2012. http://dx.doi.org/10.1109/embc.2012.6346246.
Full text"Investigation of structure differences between archaeal and human translation initiation factor 2." In Systems Biology and Bioinformatics (SBB-2021) : The 13th International Young Scientists School;. ICG SB RAS, 2021. http://dx.doi.org/10.18699/sbb-plantgen-2021-17.
Full textReports on the topic "Systems biology investigation"
Gottlieb, Yuval, Bradley Mullens, and Richard Stouthamer. investigation of the role of bacterial symbionts in regulating the biology and vector competence of Culicoides vectors of animal viruses. United States Department of Agriculture, June 2015. http://dx.doi.org/10.32747/2015.7699865.bard.
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