Dissertations / Theses: 'System interactions'

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Schulz, Steven Ernest. "System interactions and design considerations for distributed power systems." Thesis, This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-03022010-020127/.

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Tan, Lee Aun. "Immune system interactions with phospholipids." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404272.

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Oduwole, Olayinka. "Particle interactions in a magnetophoretic system." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:f01cbb33-4dd4-4057-8891-7097e6493bce.

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The continuous flow separation of magnetic particles from a mixture of particles could improve the performance of magnetic bead based assays but the formation of agglomerates limit the separation efficiency. Bead agglomerates are formed as a result of magnetic binding forces while the hydrodynamic fluid environment strongly influences their movement. The ability to predict the interaction between nearby beads will help to determine a threshold separation distance which will be recommended for use when obtaining measurement within a magnetic bead assay for a specified time interval. The introductory part of this thesis explored the development of a two dimensional numerical model in Matlab which predicts the trajectory pattern as well as magnetic induced velocities between a pair of super-paramagnetic beads suspended in water within a uniform field. The movement of a bead pair interacting due to both magnetic and hydrodynamic forces within a magnetophoretic system was recorded using an optical system; the beads' movements were compared with the simulated trajectories and gave a good agreement. The model was used to predict the shortest agglomeration time for a given separation distance which is of practical benefit to users of bead based assays. The concluding part of this thesis expanded the simulation into a three dimensional model to predict the interactions among three super-paramagnetic beads within a magnetophoretic system. In order to determine the height of the magnetic beads, a Huygens-Fresnel model was implemented in Matlab which was compared with off-focused diffracted images of the beads viewed under an optical system. A good comparison was obtained by comparing the simulated three-dimensional trajectories with experimental data.

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Schneider, Kevin Paul. "Analysis of critical infrastructure interactions /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/5990.

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Ralph, Alan. "The verbal interaction analysis system: A valid measure of competence in interpersonal interactions." Thesis, Ralph, Alan (1988) The verbal interaction analysis system: A valid measure of competence in interpersonal interactions. PhD thesis, Murdoch University, 1988. https://researchrepository.murdoch.edu.au/id/eprint/50427/.

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This thesis proposes a novel approach to the assessment of persons experiencing difficulties with interpersonal interactions. Conversation skills were selected as the focus of the research, these being an important element in such interactions. A broad review of psychological research associated with 4 different perspectives on this topic indicated a variety of approaches to defining, assessing and remediating problems Social, developmental, with interpersonal interactions. educational and clinical perspectives were explored. Clinically useful measurement procedures either evaluated the global effect of persons or evaluated specific structural components of their behaviour. The former provided little information about how to intervene to bring about improvements, while the latter failed to identify behaviour which consistently correlated with other indicators of competent performance. Valid measures from other domains were examined for their application to the assessment of conversation skills. An initial study analysed data from a sample of university students and job seekers to provide a benchmark for subsequent comparison with a newly developed measurement system. Results were interpreted to support previous research findings that component analysis measures were not appropriate. Sequential and interaction analysis concepts were adapted to develop the Verbal Interaction Analysis System. The VIAS measured the effect of verbal behaviour in interpersonal interactions by focusing on whether the topic of conversation was maintained and if contributions were made which developed the current topic. The VIAS was applied to a number of different dyadic interactions beginning with a reanalysis of the initial study. Scores obtained with this measure resulted in improved correlations with global judgements of competence and predicted high- and low- competent subjects. Subsequent experiments supported the validity of the VIAS. The VIAS was administered to a group of low-competent subjects during a social-skills training programme and was used in a clinical case study with a person experiencing difficulties with interpersonal interactions. In addition, experiments were carried out with university students to investigate the effects on the VIAS of manipulating the behaviour of the confederate or the subject during initial interactions. Results indicated that the VIAS (1) was easy to use with high inter-rater agreement. (2) was sensitive to improvements in the competence of one category of low-competent subjects during a social skills training programme, (3) assisted in the selection of target IV behaviour in a single-subject clinical intervention, and (4) was sensitive to manipulations of behaviour such as changing levels of responsibility for maintaining the interaction. The major advantage of the System was its flexibility. Empirically determined adjustments to the scoring procedure produced valid scores from a different type of interaction, as exemplified by a job interview. The potential of the System as a research tool is discussed firstly, in the context of determining the demands made in different interpersonal interactions and secondly, for its relevance as an aid to improving maintenance and transfer (generalisation) of treatment gains.

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Jadavji, Nafisa M., and University of Lethbridge Faculty of Arts and Science. "Interactions of stress and motor system function." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008, 2008. http://hdl.handle.net/10133/662.

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Stress is one of the most critical influences on behavior, performance and disease. Recent findings from our laboratory have shown that stress represents a major modulator of motor function in the intact and damaged brain. The mechanisms by which stress and stress hormones affect motor system function, however, have not yet been determined. The objective of this thesis was to determine the route of action of stress and stress hormones on the motor system in a rat model. The first experiment investigates whether corticosterone is involved in mediating stress-induced motor impairments. The second experiment compares the role of glucocorticoid and mineralocorticoid receptors in regard to modulating the motor response to stress. The third experiment determines the differential effects of stress on motor function in males and females. The final experiment systematically describes changes in neuronal cell signaling that affect normal function of motor areas. The results indicate that disturbance of fine motor control by stress is not associated with stress hormone increases. Furthermore, it is modulated through the glucocorticoid and mineralocorticoid receptors. Stress differentially impairs motor function in males and females. These changes in motor behaviour could possibly be the result of changes in neuronal cell signaling within the motor system. This research provides new insights into physiological influences in motor system function and disorders of the motor system.
ix, 128 leaves : ill. (some col.) ; 29 cm.

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Wodarz, Dominik. "Mathematical models of virus immune system interactions." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268104.

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Hewson, Emma Louise. "Multimodal interactions in a carbonated beverage system." Thesis, University of Nottingham, 2008. http://eprints.nottingham.ac.uk/11159/.

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Predicting flavour perception is complicated by interactions occurring both within and across sensory modalities, but understanding these interactions and the resulting multimodal integration is crucial to the formulation of successful products. Despite the commercial appeal of carbonated soft drinks, few studies have examined the effects of tastant: aroma: carbonation interactions on sensory perception. To facilitate these investigations, a citrus flavoured model beverage was created containing ingredients common in commercial beverages; water, aroma volatiles, sugar (glucose or fructose; equi-sweet levels), and acid (citric and lactic acid; equi-sour levels). The complexity of the beverage was gradually increased (influence of carbonation and caffeine) until the model beverage contained elements capable of stimulating gustatory, olfactory and trigeminal systems. Samples, selected according to D-optimal designs, were evaluated instrumentally (APCI-MS measuring volatile release, rheological measures of viscosity), and sensorially (using a trained panel of assessors). Predictive polynomial models were generated from mean panel data to explain variations in the attributes as a function of the design factors. The model beverages provided evidence that multi-modal interactions occurred within this model beverage system. Increasing both sugars and acids resulted in an increase in perceived citrus flavour which was not related to any alteration in volatile release measured instrumentally. Intriguingly, glucose and fructose showed different flavour perception enhancement profiles despite being used at perceptually equi-sweet levels. This difference between the monosaccharides was also evident in the predictive models generated for mouthfeel attributes. 'Overall fizziness' was dependant only on carbonation level and unaffected by levels of tastants. However, varying levels of glucose impacted on 'tingling', a relationship not mimicked by fructose. Addition of carbonation increased perceived sourness, in agreement with previous literature, but results also demonstrated a suppressive effect on perceived sweetness. Interestingly, evaluation of non-caffeinated beverages revealed the perception of a bitter aftertaste, which was primarily driven by CO2 level, enhanced by citric acid, and suppressed by increasing sugar concentration. In caffeinated beverages, however, caffeine concentration was the main influence on 'bitterness' and 'bitter aftertaste' attributes. Despite beverage manufacturers including caffeine as 'flavouring' there was little evidence to suggest caffeine concentration modified perception of citrus flavour in this system. This project provides a comprehensive assessment of the sensory profile of a model carbonated beverage. Combining instrumental and sensorial analysis provided novel evidence of the influence of multi-modal interactions on sensory perception, and highlights the differential effects of two monosaccharides on several key sensory attributes.

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Chan, S. S. M. "Interactions of Salmonella with the immune system." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597422.

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Live attenuated Salmonella that express heterologous antigens are attractive vehicles for the presentation of antigens for systemic and mucosal immunity. It is hypothesised that this requires uptake and interaction with DCs although this has yet to be studied in large animal models. This study has used pseudoafferent cannulated sheep to provide physiologically relevant DCs. However, in many other systems in vitro derived DCs are used in studies with Salmonella. Therefore we have cloned and expressed ovine IL-4 and developed protocols for derivation of in vitro generated DCs from comparison with this data. Cannulation of pseudoafferent and efferent lymphatics further allows monitoring of the earliest events of an in vivo Salmonella infection. Following in vitro infection with S. abortus ovis (a sheep specific Salmonella serotype) very few DCs were found to contain intracellular Salmonella. Avirulent Salmonella mutants were rapidly cleared from afferent lymph DCs in vitro unlike their virulent parental strains, which were found to survive and replicate intracellularly. Despite the rapid clearance of attenuated S. abortus ovis mutants from DCs, Maedi Visna virus (MVV) gag antigens expressed in these Salmonella were found to be presented to T cells. Following subcutaneous injection of aroA^- S. abortus ovis expressing MVV gag p25, Salmonella were found in the afferent lymph and cells draining the infection site. However, no bacteria were detected in the efferent lymph or cells. Phenotypic changes indicative of enhanced DC maturation in afferent lymph as well as lymphocyte activation in afferent and efferent lymph were also observed. Functional anti-Salmonella immune responses in efferent lymph were also studied. This study has established that Salmonella can infect afferent lymph dendritic cells of a large animal model. Such cells migrate to the lymph node where they initiate immune responses and can influence the cells' activation and the immune mechanisms invoked.

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McCulloch, Peter George. "Interactions between cancer and the coagulation system." Thesis, University of Aberdeen, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327905.

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Both aspects of the two way interaction between cancer and the haemostatic system were investigated. In a prospective study, Fibrinogen, Fibrinopeptide A (FPA), Fragment Bβ 15-42, Fibrin Plate Lysis Assay and Fibrin(ogen) Degradation Products (FDPs) were measured in patients with operable breast cancer (BC) patients with benign breast disease (BBD) and healthy subjects. Preoperatively, FPA and FDPs were highest in BC patients, but were also significantly elevated in BBD patients. Bβ 15-42 was elevated equally in these two groups. Neither pre nor postoperative haemostatic measurements were of any value in predicting early recurrent disease. Elevated FPA values persisted in BC patients 3 & 9 months postoperatively, whilst Bβ 15-42 rose further during this time. An association between oestrogen receptor result and Bβ 15-42 values was found. These findings suggest that much of the activation of haemostasis in cancer patients arises from non-specific causes, and that haemostatic changes do not correlate with prognosis. They suggest that a primary tumour may cause relative suppression of the fibrinolytic response. The inhibition of metastasis by warfarin was studied in an animal model. Warfarin was not cytotoxic for Mtln3 tumour cells, but inhibited metastasis. Deposition of fibrin within tumours was apparently not altered by warfarin treatment, and injection of fibrin or FDPs with tumour cells had no effect on metastasis or growth of the tumour. Pre-injection warfarin treatment of the host inhibited metastasis of Mtln3 cells, whilst pretreatment of tumour cells had no effect. Injection of factors II, VII, IX and X reversed this effect of warfarin, if given within 12 hours of tumour cells. Further studies demonstrated that factors II, IX and X together enhanced metastasis in non-anticoagulated rats. Finally, Arvin defibrination did not abolish this effect, and did not itself affect metastasis. It was concluded that the factor II, IX, X complex can enhance metastasis, and that the antimetastatic effect of warfarin appeared to be due to inhibition of these proteins. Since enhancement was not affected by defibrination, it may occur via mechanisms other than fibrin formation.

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Davies, Thomas Glanmor. "Protein-ligand interactions for the OppA system." Thesis, University of York, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311012.

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Ali, Asad. "Multitrophic interactions in a potato-aphid system." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6356.

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In interactions between plants, insect herbivores and natural enemies, resistant plant varieties and soil abiotic/biotic factors can affect natural enemies through changes in the plant or host insect. Interactions can be negative, neutral or positive in relation to herbivore populations. The majority of studies have used above-ground plant–insect–parasitoid systems and relatively few studies have included below-ground effects on above-ground tritrophic interactions. The aim of the present project was to understand how soil-based stress factors (nutrient availability and root pathogens) influence multitrophic interactions in a potato-aphid (Myzus persicae)-parasitoid (Aphidius colemani) system. Specific objectives were: to assess aphid performance on different potato cultivars under laboratory and field conditions; use aphid resistant and susceptible cultivars to assess the effects of soil nutrition and a plant pathogen (root-knot nematode) on aphid performance; conduct multifactorial ditrophic (aphid performance) and tritrophic (parasitism success) experiments with selected combinations of soil treatments; use olfactometry to determine whether plant volatiles are involved where significant tritrophic interactions occur between treatments. Potato cv. Anya, a cv derived from Desiree and Pink Fir Apple, was found to be consistently resistant to M. persicae compared with the three other cultivars tested (Desiree, Santé and Pink Fir Apple) in both laboratory experiments (UK) and field trials (Pakistan and UK). For Anya (resistant) and Desiree and Pink Fir Apple (susceptible), high levels of soil nutrients enhanced aphid performance, their parasitism by A. colemani, and adult parasitoid emergence. Root-knot nematodes had a negative effect on aphid performance at both low and high soil nutrition but had a positive effect on parasitism at low soil nutrition. Olfactometry showed Desiree to be more attractive to M. persicae compared with Anya. The work is discussed in relation to the development of pest management strategies for the control of M. persicae on potato.

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Wright, Fiona Louise. "System interactions in the regulation of appetite." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/6440/.

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Despite the huge range of neurobiological targets within the appetite system, the development of pharmacological anti-obesity agents is making slow progress as a result of limitations on maximal weight loss, adverse side-effects, and/or long-term resistance. However, in principle, the use of drug polytherapy allows for the use of lower doses, possible synergistic/additive weight loss, fewer and less serious side-effects and reduced potential for counter-regulation. Although food intake and/or bodyweight have been and are being researched following co-treatment with a range of agents, there is a distinct gap in the literature regarding the behavioural specificity of the anorectic effects for recently approved and upcoming anti-obesity therapies. The present thesis therefore characterised the acute effects of individual systemic (i.p.) treatment with the general opioid receptor antagonist naltrexone (0.1, 1.0 and 3.0mg/kg), the noradrenaline and dopamine reuptake inhibitor bupropion (10, 20 and 40mg/kg), the serotonin 5-HT1B/2C receptor agonist mCPP (0.1, 1.0 and 3.0mg/kg), and the GLP-1R mimetic exendin-4 (0.025, 0.25, and 2.5μg/kg), on food intake, feeding and non-feeding behaviour, the behavioural satiety sequence (BSS), and weight gain. In addition, the acute anorectic response to co-treatment with sub-maximal doses of each non-opioid compound plus an opioid antagonist (naloxone or naltrexone) was assessed. The results suggested that, while the anorectic effects of naloxone and naltrexone were behaviourally-selective, those of rimonabant, bupropion, mCPP and exendin-4 may have largely resulted from competing behaviour. The co-treatment studies highlighted concurrent anorexia and an undesirable behaviour for rimonabant, bupropion and, potentially, mCPP. However, the anorectic action of mCPP and exendin-4 may have largely resulted from malaise. The results further showed that, while only the combination of bupropion and naltrexone produced an additive effect on food intake, co-treatment with an opioid antagonist reduced/eliminated unwanted effects normally associated with higher doses of rimonabant, bupropion and, potentially, mCPP. The search for efficacious and safe anti-obesity agents should therefore focus, to an even greater extent than at present, on the therapeutic potential of targeting multiple systems (polytherapy). Overall, current findings have emphasised the value of detailed behavioural analysis of drug effects on appetite. As such, novel treatment combinations may well produce a successful anti-obesity agent, if clinical trials are prefaced by adequate preclinical testing.

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Ford, Sarah Theresa. "Analysing doctor-patient interactions in oncology : the development of the medical interaction process system (MIPS)." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272373.

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Kunz, Barbara Claudia. "The microsomal monooxygenase system : interactions of the components /." [S.l.] : [s.n.], 1986. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=8084.

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Fitzgibbon, Frances. "Woolly apple aphid : interactions within an orchad system /." Title page, contents and summary only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phf5542.pdf.

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Hutchinson, S. J. "Spatio-chromatic interactions in the human visual system." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411198.

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Panni, Moeen. "Neuron-target interactions in the central nervous system." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337889.

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Gu, Shuang. "Secretin interactions in the type II secretion system." Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/2482.

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The type II secretion system (T2SS) is the major terminal branch of the general secretory pathway. It is composed of 12-15 proteins, most in multiple copies, and spans the inner and outer membranes of Gram-negative bacteria. The T2SS secretin subunits form a large dodecameric torus-like structure in the outer membrane. The secretin is the only essential component in the outer membrane and secreted proteins and virulence factors pass through the pore in the toroidal secretin dodecamer and out into the environment. The interaction between the secretin and its partners plays a key role in regulation of the T2SS. The interaction between the so-called homology region of the innermembrane protein GspC (GspC-HR) and secretin provides the structural and functional integrity of the secretion machinery across the two cell membranes. The interaction between secretin and its pilotin translocates the secretin subunits to the outer membrane. In this Thesis, the interactions between secretin and its partners are studied at molecular level. The GspC-HR structure is solved using NMR spectroscopy. Its interaction with secretin (GspD) is elucidated using several biochemical and biophysical approaches and a model of the complex is proposed. Also, the interaction between secretin (GspD) and pilotin (GspS) is further charicterisied. An 18 residues secretin sequence is identified as responsible for interacting with pilotin. Upon binding to the pilotin, the unstructured secretin forms a helical structure.

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20

Brenner, Andrew J. "Tree-crop interactions within a Sahelian windbreak system." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/12747.

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The advantages of windbreak in terms of reducing soil erosion and providing tree products for farmers in the Sahel are well known. There is less certainty about the effect of shelter on crop growth, the degree of competition for water and light between windbreak and crop, and almost no information on the amount of water a windbreak transpires over a year. Field measurements of millet (Pennisetum typhoides) growth and microclimate behind a young double row neem (Azardirachta indica) windbreak at the ICRISAT Sahelian Centre, Sadore, Niger, were carried out in 1988 and 1989. Measurements of tree transpiration were made using a commercial sap flow meter, along with measurements of tree heights, stem basal areas and leaf areas. The reduction in wind speed produced by the windbreak changed over the season, as a result of the reduction of the porosity of the lower half of the windbreak by the growth of the millet crop on the windward side of the windbreak. Maximum shelter was found at 6h at the beginning of the cropping season and 3h during the middle and end of the season, where h is the height of the windbreak. Factors influencing the magnitude of shelter are discussed.

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Almeida, Rafael. "Axon-glia interactions during central nervous system myelination." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/21038.

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Myelination drastically speeds up action potential propagation along axons, which is fundamental for the correct function of neuronal circuits. However, axon-oligodendrocyte interactions regulating the onset of myelin formation remain unclear. I sought to determine how reticulospinal axons control myelination, as they are the first myelinated in the zebrafish spinal cord. I genetically manipulated zebrafish in order to either remove such axons from a region of the spinal cord, or to increase their number, and characterized oligodendrocyte-lineage cells following this axonal loss- or gain-of-function. In kinesin-binding protein (kbp) mutants, reticulospinal hindbrain neurons start axonogenesis but axons fail to grow along the entire spinal cord as in wildtype, providing an axon-deficient posterior spinal cord and an intact anterior region. I found that early stages of oligodendrocyte development, such as the specification of oligodendrocyte precursors, their distribution and migration were not affected in the posterior spinal cord of these mutants. However, both the proliferation and the survival of late precursors were impaired, resulting in a significant reduction of mature oligodendrocytes in the posterior region of mutants at the onset of myelination. Since the anterior spinal cord of mutants is indistinguishable from wildtype, these results demonstrate that reticulospinal axons provide a mitogenic and a survival signal to a subset of developing OPCs, enabling their differentiation and lineage progression. I then found that the absence of reticulospinal axons did not affect the timing of oligodendrocyte differentiation, which matured on time, suggesting that this follows an intrinsic timer, as previous studies suggested. Oligodendrocytes also did not myelinate incorrect axonal targets, but instead adapted to the reduced axonal surface by elaborating fewer myelin sheaths. Additionally, oligodendrocytes made shorter sheaths, and also incorrectly ensheathed neuron somas in the mutant spinal cord, suggesting that either kbp function or a precise amount of axonal surface are required to prevent ectopic myelination of somas and to promote the longitudinal growth of myelin sheaths. In wildtype animals, the two reticulospinal Mauthner axons are the very first myelinated in the spinal cord. In animals where Notch1a function is temporarily abrogated or hoxb1 genes are temporarily upregulated, supernumerary Mauthner neurons are generated. I found that these extra axons are robustly myelinated, with no impairment of myelination of adjacent axons. Surprisingly, the number of oligodendrocytes was not altered, but I found that each individual oligodendrocyte elaborated more myelin sheaths, whose total length was also longer than in wildtypes. Additionally, dorsal oligodendrocytes, which normally myelinate only small-calibre dorsal axons, readily extended processes ventrally to myelinate the supernumerary large-calibre Mauthner axons, in addition to small-calibre axons. These results suggest that oligodendrocytes are plastic and are not destined to myelinate a particular type of axon, and conversely, that axonal signals that induce myelination are similar for different axons. The long-standing observation that oligodendrocytes tend to myelinate either few large axons or many small axons thus reflects local interactions of oligodendrocyte processes with the nearby axons, rather than different subtypes of oligodendrocytes specified by an intrinsic programme of differentiation. Collectively, this work shows that axons extensively influence both oligodendrocyte lineage progression and oligodendrocyte myelinating potential in vivo.

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Myers, Owen Dale. "Spatiotemporally Periodic Driven System with Long-Range Interactions." ScholarWorks @ UVM, 2015. http://scholarworks.uvm.edu/graddis/524.

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It is well known that some driven systems undergo transitions when a system parameter is changed adiabatically around a critical value. This transition can be the result of a fundamental change in the structure of the phase space, called a bifurcation. Most of these transitions are well classified in the theory of bifurcations. Among the driven systems, spatiotemporally periodic (STP) potentials are noteworthy due to the intimate coupling between their time and spatial components. A paradigmatic example of such a system is the Kapitza pendulum, which is a pendulum with an oscillating suspension point. The Kapitza pendulum has the strange property that it will stand stably in the inverted position for certain driving frequencies and amplitudes. A particularly interesting and useful STP system is an array of parallel electrodes driven with an AC electrical potential such that adjacent electrodes are 180 degrees out of phase. Such an electrode array embedded in a surface is called an Electric Curtain (EC). As we will show, by using two ECs and a quadrupole trap it is posible to produce an electric potential simular in form to that of the Kapitza pendulum. Here I will present the results of four related pieces of work, each focused on understanding the behaviors STP systems, long-range interacting particles, and long-range interacting particles in STP systems. I will begin with a discussion on the experimental results of the EC as applied to the cleaning of solar panels in extraterrestrial environments, and as a way to produce a novel one-dimensional multiparticle STP potential. Then I will present a numerical investigation and dynamical systems analysis of the dynamics that may be possible in an EC. Moving to a simpler model in order to explore the rudimentary physics of coulomb interactions in a STP potential, I will show that the tools of statistical mechanics may be important to the study of such systems to understand transitions that fall outside of bifurcation theory. Though the Coulomb and, similarly, gravitational interactions of particles are prevalent in nature, these long-range interactions are not well understood from a statistical mechanics perspective because they are not extensive or additive. Finally, I will present a simple model for understanding long-range interacting pendula, finding interesting non-equilibrium behavior of the pendula angles. Namely, that a quasistationary clustered state can exist when the angles are initially ordered by their index.

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Murakami, Yoshinobu. "Interactions of polyanions with the serum complement system." 京都大学 (Kyoto University), 2003. http://hdl.handle.net/2433/148877.

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Kamatsos, Paraskevas. "Smart Homes : Human interactions and IoT." Thesis, Linnéuniversitetet, Institutionen för informatik (IK), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-53427.

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This thesis studies the phenomenon of human-system interaction in smart homes as a practice of Internet of Things. The research was conducted through interviews, workshops and observations and followed an interpretive research paradigm of phenomenologically-situated paradigm of HCI and a qualitative research approach. The theories of Phenomenology and Postphenomenology were used to interpret the experiences, beliefs and views of the participants. The empirical findings were processed and a thematic analysis was followed in order to identify the main themes that emerged out of the interviews, workshops and observations. The discussion of the findings showed that the research questions were answered to the grade that the participants of the research design, use and interact with smart homes in a multiple and complex way.

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Santin, Joseph M. "Context-dependence of physiological systems: environment-physiology interactions in the respiratory control system." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright149336916471128.

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周韋基 and Wai-kei Dominic Chau. "A morphometric study of axon-glial interactions." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1995. http://hub.hku.hk/bib/B31212141.

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Chau, Wai-kei Dominic. "A morphometric study of axon-glial interactions /." [Hong Kong] : University of Hong Kong, 1995. http://sunzi.lib.hku.hk/hkuto/record.jsp?B14801486.

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Preston, Alexandra McEwan. "Interactions of immunoglobulin superfamily leukocyte cell surface molecules." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318630.

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Underwood, Jennifer E. (Jennifer Elizabeth). "Distributed satellite communications system design : first-order interactions between system and network architectures." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/32455.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 2005.
Includes bibliographical references (p. 159-165).
Humanity now exists in the midst of the fast-moving Information Age, a period of history characterized by fast travel and even faster information transfer. As data becomes seemingly more valuable than physical possessions, the introduction of exciting applications for communications services becomes ever more critical for the success - and in some cases, survival - of businesses and even nations. While the majority of these innovations have occurred over cable and fiber, a number of the most socially significant have occurred due to the introduction of satellites. Terrestrial fiber and cable systems have a number of advantages, but the extent of their reach and the cost of installation - in terms of both capital and time - favor industrialized nations over more remote and underdeveloped communities. Even as satellites offer the only real chance for ultimate communications ubiquity and true global unity, there remains a significant cost-benefit barrier. Few commercial satellite systems have succeeded economically without first falling victim to bankruptcy. The upfront capital required to implement a satellite communications system is staggering, and historically satellite companies have failed to adequately match capacity and service options to the current and actual future demand. The design process itself is an inherent limiting factor to the achievable cost and performance of a system.
(cont.) Traditionally, the first step toward designing satellite communication systems - as well as terrestrial, sensor web, and ad hoc networks - has been to specify the system topology (e.g., the orbits of the satellites and the locations of the ground stations) based on the desired market and then to design the network protocols to make the most of the available resources. Such a sequential process assumes that the design of the network architecture (e.g., protocols, packet structure, etc) does not drive the design of the system architecture (e.g., constellation topology, spacecraft design, etc). This thesis will show that in the case of Ka-band distributed satellite communication systems this fundamental assumption is not valid, and can have a significant impact on the success (cost, capacity, customer satisfaction) of the resulting satellite communication system. Furthermore, this thesis will show that how a designer values performance during the design and decision process can have a substantial impact on the quality of the design path taken through the trade space of possible joint architectures.
by Jennifer E. Underwood.
S.M.

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McAndrews, Gary Michael. "Autonomous agent interactions in a real-time simulation system." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1994. http://handle.dtic.mil/100.2/ADA291864.

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Neumann, Anthony. "Bacterial interactions with anthracene in a model soil system." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/mq22647.pdf.

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Cheung, Natalie Wen Yua. "Energy Mobility Network : system design, interfaces, and future interactions." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/66412.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2011.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 128-129).
The Energy Mobility Network is a mobile, networked energy production, consumption and sharing system that is designed to motivate users to be more aware of their energy consumption. In particular, the system provides a just-in-time message to the user before using the device, which allows the user to evaluate his/her needs and the cost of the device. Furthermore, the idea of minimizing electrical costs are extended into the social realm; the system creates a social network among users which allow social energy etiquettes to come into play. With these etiquettes, the system aims to use social means as a way to minimize the use of electricity. In the thesis, I discuss the goals and ideas developed that led to the creation of the network and the technical infrastructure behind the system. I will be going in depth with the prototyping, the pros and cons, as well as the multiple versions of the system that have been prototyped. Finally, I will discuss the future possibilities the Energy Mobility Network will bring when introduced to the general public.
by Natalie Wen Yua Cheung.
M.Eng.

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de, Bettignies A. S. "Wnt/Fz interactions in the developing central nervous system." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444543/.

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Wnt signalling is central to many early developmental processes including embryonic patterning, programmed cell death and cell migration. Recent studies have implicated Wnt signalling in the formation of neuronal connections in the nervous system. Wntl a regulates synapse formation in the cerebellum by inducing presynaptic differentiation characterized by axonal remodelling and presynaptic assembly. A very similar gene, Wnt7b regulates dendritic development in hippocampal neurons, but can also trigger axonal remodelling. These different responses are due to the activation of different signalling pathways. We aim to identify the receptors triggering these processes in neurons. Intracellular signalling by Wnts is initiated by the activation of their seven transmembrane receptors Frizzled (Fz). Three known Wnt signalling pathways may be activated: the canonical, the planar cell polarity and Calcium pathways. Ten Fz receptors and 19 Wnts have been identified in the mouse genome. To begin to address what Fz receptors are used by Wnts, we examined the pattern of expression of Wnt 7a and Wnt 7b together with several Fz receptors during postnatal brain development. We found that Wnt7a,fz7, and fz3 are expressed in the postnatal and adult cerebellum. Wnt7b and fz3 are highly expressed in the postnatal hippocampus. These overlapping patterns of expression led us to investigate the ability of Wnt7a and Wnt7b to bind to the cell surface of HEK293 cells expressing the ligand-binding domain of Fz receptors. Binding of Wnt7a an -7b to Fz-3, -5, -7 and -8 was tested. Wnt7b binds Fz3 and Fz5, whilst Wnt7a binds Fz7 and Fz3. Signalling activity was then assessed by measuring TCF/LEF mediated transcription (Top-Flash assay) and by the increased levels of 6-catenin. Wnt-7a is able to activate the canonical pathway in Fz7 and Fz3/LRP6 transfected HEK293 cells. These studies highlight the idea that activation of the canonical / p-catenin pathway by Wnt7a can be mediated by Fz7 and the LRP6/Fz3 complex.

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McCarvil, James. "Bacterial interactions with metals in the activated sludge system." Thesis, Glasgow Caledonian University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377697.

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Goodyear, Michael Cooper. "Organic chemistry and mineral interactions in the solar system." Thesis, Open University, 2013. http://oro.open.ac.uk/54719/.

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The objective of this project was to develop methods to detect meteoritic organic compounds in situ, and to detelmine whether any associations exist between specific classes of compound and co-located minerals, thus indicating a possible common origin. Carbonaceous chondrites, (which comprise a small proportion of meteorites), contain a few per cent of organic material, heterogeneously distributed within their structure, the major part being macromolecular ("insoluble organic material", lOM). Model compounds were covalently bonded to "molecular tags", atoms or groups not normally present in meteorites, enabling easier detection against background signals when using analytical methods suitable for use in situ, such as Raman spectroscopy or SEM. Also, extra functionality was introduced to model compounds by ozone treatment, allowing a greater density of tags to be attached. Following development work with terrestrial models, meteorite samples were exposed to ozone, but oxalic acid was formed instead of the expected oxygenated IOM derivative. To determine if this result was due to an effect of the minerals present, whole rock samples and demineralised IOM were analysed, both before and after exposure to ozone. Isolated IOM behaved differently from that still in situ. Fresh samples ofIOM were isolated (using two literature methods), and their reactions and properties compared. The evidence obtained indicated that the structure of IOM had been modified on isolation, and that the modifications caused by the two methods were different. This shows that any data generated from isolated IOM does not necessarily directly relate to organic material still present within a meteorite. Using the data obtained in this study, and that previously reported, two-component models for the structure of lOM, and scenarios for its formation, were discussed.

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Widmer, Colin Leigh. "Explanative and Argumentative Interactions with an Intelligent Tutoring System." Miami University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1386173705.

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Alvarez, Contreras Carlos Alberto. "HOST-MICROBIOME INTERACTIONS AND REGULATION OF THE IMMUNE SYSTEM." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1600446008947681.

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Harding, Rachel Jane. "Interactions of Neisseria meningitidis with the human immune system." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:cc6162f9-3305-43d6-ae33-ecd34530e18d.

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Neisseria meningitidis is an obligate human pathogen causing over 1000 cases of meningococcal disease within the U.K., 10 % of which result in long-term disability or fatality. 10-70 % of the population carry N. meningitidis in their nasopharynx, the natural reservoir of this bacterium, as a commensal. The host-pathogen interactions of this species are complex and a greater understanding of the molecular mechanisms involved in pathogenesis and immune evasion is required. Three aspects of N. meningitidis pathogenesis were explored in this study. One mechanism of immune evasion which promotes serum resistance of N. meningitidis is recuitment of complement factor H through domains 6 and 7 (fH₆₇) by factor H binding protein (fHbp). In this study, mouse fH₆₇ was recombinantly expressed and purified. fHbp did not bind mouse fH₆₇ at physiologically relevant protein concentrations. The structure of mouse fH₆₇ was solved, showing differences in domain orientation and surface chemistry compared to the human version of this protein, potentially accounting for the host specificity of this interaction. Type IV pili (T4P) are crucial adhesins of N. meningitidis, the fibre of which is composed of thousands of copies of PilE. A method was developed to recombinantly produce large quantities of this protein from a variety of meningococcal strains and the structure was solved of one PilE protein. Subsequent analysis was performed with the PilE proteins investigating their interaction with the putative pilus receptor CD46 and human epithelia as well as their immunogenicity. A method was also established to produce PilC, the proposed tip-assocoated adhesin of T4P. ZapE has recently been identified as an important protein in pathogen colonisation, functioning as an ATPase linked to Z-ring formation in bacterial cell fission. Both N. meningitidis and E. coli ZapE were recombinantly produced. The domain boundaries were mapped and ATPase activity was confirmed. No interaction was seen with FtsZ but DNA binding and modulation was observed by shift assays, the exact function of which remains to be elucidated in future studies.

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Kroposki, Benjamin David. "A methodology to study photovoltaics and storage system interactions." Thesis, This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-03242009-040410/.

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Ceballos, Germán. "Modeling the interactions between tasks and the memory system." Licentiate thesis, Uppsala universitet, Avdelningen för datorteknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-335530.

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Making computer systems more energy efficient while obtaining the maximum performance possible is key for future developments in engineering, medicine, entertainment, etc. However it has become a difficult task due to the increasing complexity of hardware and software, and their interactions. For example, developers have to deal with deep, multi-level cache hierarchies on modern CPUs, and keep busy thousands of cores in GPUs, which makes the programming process more difficult. To simplify this task, new abstractions and programming models are becoming popular. Their goal is to make applications more scalable and efficient, while still providing the flexibility and portability of old, widely adopted models. One example of this is task-based programming, where simple independent tasks (functions) are delegated to a runtime system which orchestrates their execution. This approach has been successful because the runtime can automatically distribute work across hardware cores and has the potential to minimize data movement and placement (e.g., being aware of the cache hierarchy). To build better runtime systems, it is crucial to understand bottlenecks in the performance of current and future multicore systems. In this thesis, we provide fast, accurate and mathematically-sound models and techniques to understand the execution of task-based applications concerning three key aspects: memory behavior (data locality), scheduling, and performance. With these methods, we lay the groundwork for improving runtime system, providing insight into the interplay between the schedule's behavior, data reuse through the cache hierarchy, and the resulting performance.
UPMARC

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Hoving, J. J. A. "Homotypic and heterotypic interactions in the peripheral nervous system." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1529259/.

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Peripheral nerves have a remarkable ability to regenerate following a transection injury. To achieve this, Schwann cells collectively migrate as cords, taking regrowing axons across newly formed tissue known as the bridge that forms to reconnect the two nerve stumps. The Schwann cell cords themselves are guided by a newly formed polarised vasculature that provides a conducive environment for Schwann cell migration. Here we show, that in addition to mediating Schwann cell clustering, N-cadherin is required for contact inhibition of locomotion (CIL) in Schwann cells, which may be required to produce an outward force within the cords of collectively migrating Schwann cells. Mechanistically we show that N-cadherin regulates CIL independent of its traditional mechanism of trans-homodimerisation and independent of adherence junction components. Instead, the extracellular domain of N-cadherin is sufficient to mediate CIL, which appears to present a repulsion (co-)signal to the other cell. We further show, that CIL is disrupted in Schwann cells expressing oncogenic Ras in a MEK-dependent manner, not through loss of N-cad, but through loss of a distinct signal. Ras-Raf-MEK-ERK signalling alters the mRNA expression levels of ephrins and Eph receptors, and we show using Co-IP and mass spectrometry, that oncogenic Ras changes the interaction profile of N-cadherin proteins and show a potential role for glypican-4 and ephrin-A1 in CIL. Finally, we show that migration of Schwann cells along the vasculature is independent of focal adhesion complexes, consistent with the more amoeboid-mode of migration observed along the blood vessels.

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Chen, Hsinchun, and Vasant Dhar. "Online Query Refinement on Information Retrieval Systems: A Process Model of Searched System Interactions." ACM, 1990. http://hdl.handle.net/10150/105597.

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Artificial Intelligence Lab, Department of MIS, University of Arizona
This article reports findings of empirical research that investigated information searchers online query refinement process. Prior studies have recognized the information specialists' role in helping searchers articulate and refine queries. Using a semantic network and a Problem Behavior Graph to represent the online search our study revealed that searchers also refined their own queries in an online task environment. The information retrieval system played a passive role in assisting online query refinement, which was, however, one that confirmed Taylor's four-level query formulation model. Based on our empirical findings, we proposed using process model to facilitate and improve query refinement in an online environment. We believe incorporating this model into retrieval systems can result in the design of more "intelligent" and useful information retrieval systems.

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Naidu, I. Ajit. "Design and development of SINK, a software INteractions knowledge system." Master's thesis, This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-12232009-020100/.

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Eberhart, Johann. "EphA4/Ephrin interactions in motor axon guidance /." free to MU campus, to others for purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3060095.

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Lindström, Karin M. "Bird-parasite interactions : Using Sindbis virus as a model system." Doctoral thesis, Uppsala University, Department of Evolutionary Biology, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-486.

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This thesis focuses on the evolutionary interactions between birds and a parasite, the mosquito-borne Sindbis virus (Togaviridae, Alphavirus). In conclusion, the results show that the Sindbis virus is widespread among birds, and that the fitness of infected hosts may be reduced by the virus. Furthermore, viruclearance ability was revealed by male plumage traits, and viraemia was related to hormonal- and social status.

The distribution of Sindbis virus infections among passerine birds was examined in five areas in Sweden. Almost all species tested were infected, and three species of thrushes weridentified as the main hosts. In a series of experimental infections, greenfinches (Carduelis chloris) kept in aviaries were used ahosts. First, the behavioural consequences of an infection were investigated. During the infection, birds tended to reduce thespontaneous locomotion activity, and when escaping from a simulated predator attack, infected birds had reduced take-off spee Furthermore, when comparing virus clearance rate between male greenfinches, I found that males with large yellow tail ornaments hafaster virus clearance rates as compared to those with smaller ornaments. Thus, male virus clearance ability was honestly revealed by the size of an ornament. Moreover, males with experimentally elevated testosterone levels experienced a delayed, but not increased viraemia as compared to controls. When the relationship between male social ranand viraemia was examined, I found no evidence that high-ranked males suffered reduced rank during the infection. Nevertheless, viraemipatterns of males were related to their social rank, so that low-ranked birds had a delayed viraemia as compared to high-ranked birds.

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Madanian, Hadi. "External Plasma Interactions with Nonmagnetized Objects in the Solar System." Thesis, University of Kansas, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10282984.

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The absence of a protecting magnetic field, such as the dipole magnetic field around Earth, makes the interaction of solar wind with unmagnetized objects particularly interesting. Long-term evolution of the object’s surface and atmosphere is closely tied to its interaction with the outer space environment. The ionospheric plasma layer around unmagnetized objects acts as an electrically conducting transition layer between lower atmospheric layers and outer space. This study considers two distinct types of unmagnetized objects: Titan and comet 67P/Churyumov-Gerasimenko (67P/CG). For many years, Titan has been a key target of the National Aeronautics and Space Administration (NASA) Cassini mission investigations; and the European Space Agency (ESA) Rosetta spacecraft explored comet 67P/CG for more than two years.

Ionospheric composition and primary ion production rate profiles for Titan are modeled for various solar activity conditions. Photoionization is the main source of ion production on the dayside; on the nightside, electron-impact ionization is the main ionization source. This dissertation uses model results and in-situ measurements by the Ion and Neutral Mass Spectrometer (INMS) and the Langmuir Probe (LP) onboard the Cassini spacecraft to show that while the solar activity cycle impacts the primary ion species significantly, there is little effect on heavy ion species. Solar cycle modulates the Titan’s ionospheric chemistry. The solar cycle effects of on each ion species are quantified n this work. In some cases the solar zenith angle significantly overshadows the solar cycle effects. How each individual ion reacts to changes in solar activity and solar zenith angle is discussed in details. A method to disentangle these effects in ion densities is introduced.

At comet 67P/CG, the fast-moving solar wind impacts the neutral coma. Two populations of electrons are recognizable in the cometary plasma. These are the hot suprathermal electrons, created by photoionization or electron-impact ionization, and the cold/thermal electrons. Even though photoionization is the dominant source of ion production, electron-impact ionization can be as high as the photoionization for certain solar events. At 3 AU, electron energy spectra from in-situ measurements of the Ion and Electron Sensor (IES) instrument exhibit enhancement of electron fluxes at particular energies. Model-data comparisons show that the flux of electrons is higher than the typical solar wind and pure photoionization fluxes. The probable cause of this enhancement is the ambipolar electric field and/or plasma compression.

This research also discusses formation of a new boundary layer around the comet near perihelion, similar to the diamagnetic cavity at comet 1P/Halley. At each crossing event to the diamagnetic cavity region, flux of suprathermal electrons with energies between 40 to 250 eV drops. The lower flux of solar wind suprathermal electrons in that energy range can cause this flux drop.

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Ostrovsky, Lena. "Thrombin-induced neutrophil-endothelial cell interactions in a human system." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0013/MQ34984.pdf.

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Williams, David C. (David Charles). "Observations of medical professionals' interactions with an intelligent tutoring system." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59588.

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Intelligent tutoring systems (ITS) are expert systems united with computer-aided instruction. The psychological issue of human-computer interfacing combines aspects of education, cognitive science, human performance and psycho-sociolinguistics. This study presented a situation in which physicians used their reasoning to solve a computer-simulated medical case, embedded in the NEOMYCIN ITS. Experiments were designed to assess how their anthropomorphisation of the systems affected their medical reasoning in a complex ill-defined problem-solving domain. The study examines the subjects' interpretation of textual case materials, specifically their ascription of meaning and intelligibility to the form and usage of natural language. The results indicate that these factors affect their interpretation, not only of case materials, but also of their evaluation of the program's medical reasoning. This has implications for the interactive man-machine interface and its relationship to interpersonal communication is discussed.

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Mihaylov, Petar. "Investigation of long-range interactions in the human visual system." Thesis, Glasgow Caledonian University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.547413.

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Ahmad, Asma. "Protein-protein interactions in the bacterial type VI secretion system." Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/4811/.

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Dissertations / Theses on the topic 'System interactions'

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