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Brand, Elizabeth Gertruida. "Selectable markers for recombinant poxvirus." Thesis, University of Cape Town, 1993. http://hdl.handle.net/11427/25692.
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Meendering, Jessica Rae. "The influence of progestins on biomarkers of cardiovascular risk in young women /." view abstract or download file of text, 2007. http://proquest.umi.com/pqdweb?did=1400968571&sid=4&Fmt=2&clientId=11238&RQT=309&VName=PQD.
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Thesis (Ph. D.)--University of Oregon, 2007.Typescript. Includes vita and abstract. Includes results of four studies conducted at the University of Oregon. Includes bibliographical references (leaves 221-244). Also available for download via the World Wide Web; free to University of Oregon users.
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Харабар, Владислав Володимирович. "Підсистема визначення позиції в просторі для мобільного додатку навігації з використанням доповненої реальності." Master's thesis, КПІ ім. Ігоря Сікорського, 2019. https://ela.kpi.ua/handle/123456789/31883.
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Метою роботи є створення підсистеми визначення позиції для мобільного додатку навігації з використанням доповненої реальності.
Об’єктом дослідження є системи внутрішньої навігації на основі комп’ютерного зору. Було виконано огляд підходів та технік визначення позиції мобільного пристрою в приміщеннях та зроблені висновки щодо їх переваг та недоліків. Створено модуль позиціонування в складі мобільного додатку для смартфонів, що базується на поєднанні SLAM та маркерів ArUco. Продукт можна використовувати для потреб внутрішньої навігації. Було подано тези на щорічну студентську конференцію «Сучасні проблеми наукового забезпечення енергетики».Relevance of the topic Nowadays navigation services have become an integral part of our lives. The vast majority of mobile devices support global GPS positioning. However, it is not possible to use it inside buildings. In these cases, specific technologies that often require modified mobile devices have to be developed. On the IPIN market, the main approach now is to use BLE beacons and signals from existing Wi-Fi access points. However, both methods require considerable investment of money and time. Today's smartphones have reached a level of performance that supports real-time camera image stream processing and determining the relative movement of the device. The combination of these factors makes the development of optical positioning systems for mobile devices extremely relevant. The purpose of research is the creation of a positioning subsystem for the mobile indoor navigation application, which helps users to find away to the points of interest and accompanies to them by providing interactive instructions using augmented reality. To achieve this goal, we need to complete the following research objectives: — to consider, analyze and compare methods of indoor position determination; — to develop an indoor positioning service based on the chosen approach; — integrate the subsystem with other components of the software product. Object of study: Indoor positioning methods based on computer vision. Subject of study: A visual-inertial indoor positioning system for navigation using smartphones. Research methods: To solve the problem, we use software architecture design methods, theory of data flows modeling, object-oriented analysis of the domain. Scientific novelty: Internal positioning system has been improved by combining visual-inertial odometry with synthetic markers, which has led to the possibility of developing a localization system without deploying expensive devices for receiving or transmitting signals. Practical meaning is that the developed application can be used for the purposes of finding rooms in educational buildings, as well as for object annotation. The functionality of the application allows you to replace the map of the facility to reuse in other fields. Approbation. The results of the research were discussed at the 17th Scientific and Practical Conference of Young Scientists and Students "Modern Problems of Scientific Support for Energy" held in Kyiv, April 23-26, 2019.Structure and volume of the thesis The master's thesis consists of an introduction, five sections and conclusions, a list of references with 46 sources; includes 25 figures, 25 tables and 2 appendices. The full amount of work is 112 pages, 5 of them — references list and appendices — 13 pages. The introduction substantiates the need to develop new approaches to navigation, sets a research goal, and defines the task of development. The first section describes the concept of navigation. It describes the practical importance of internal positioning systems and their potential applications. Determines place of the subsystem in the resulting application and its data flow. The second section explores the basic techniques and technologies for indoor navigation positioning. Attention is especially focused on the SLAM method. Existing software systems, their advantages and disadvantages are analyzed. An approach combining SLAM and synthetic markers is proposed. Justified the choice of ArUco markers. The third section is devoted to the software implementation of the subsystem. We describe used development tools, structure and configuration of the developed product. The fourth section provides instructions on how to deploy, install, and use the software product — mobile application. The fifth section provides an analysis of possibilities to implement the product as a startup project. We identified development and marketing strategies, conducted a SWOT-and financial analysis and described risk and opportunity factors. The conclusions set out the results of the work and provide recommendations for further research on the topic. The appendices contain the program code of the developed subsystem and the abstracts for the conference where the dissertation materials were discussed.
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Bachmann, Martin [Verfasser], Annette [Akademischer Betreuer] Zeyner, and Gerhard [Akademischer Betreuer] Breves. "Methodic investigations on the suitability of plant and synthetic n-alkanes as markers to predict feed intake and digestibility in horses : [kumulative Dissertation] / Martin Bachmann ; Annette Zeyner, Gerhard Breves." Halle, 2016. http://d-nb.info/1122438656/34.
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Kretzschmar, Tim [Verfasser]. "Effects of a synthetic serine protease inhibitor, camostat mesilate (FOY-305), on markers of pancreatic acinar cell damage, inflammation, and fibrosis in dogs with suspected naturally occuring chronic pancreatitis / Tim Kretzschmar." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1072410664/34.
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Kazachkova, Nadiya. "Genotype analysis and studies of pyrethroid resistance of the oilseed rape (Brassica napus) insect pest - pollen beetle (Meligethes aeneus) /." Uppsala : Department of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/200711.pdf.
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Páldy, Alexander. "Vylepšování markerů pro rozšířenou realitu." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2013. http://www.nusl.cz/ntk/nusl-235464.
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Tato práce stručně popisuje moderní metody v rozšířené realitě a dále se zabývá generováním a detekcí Uniform Marker Fields. Hlavním cílem je zlepšovat markery známé jako Unifrom Checker-Board Marker Fields. Toho je dosaženo několika vylepšeními návrhu těchto markerů. Mezi hlavní patří využití širší barevné palety, zaměření na podobnost s vybraným obrázkem a změna tvaru modulů. Výsledný algoritmus byl navržen ke generování právě takových markerů. Výstupem jsou esteticky vypadající markery, které umožňují spolehlivou detekci i v případě výrazného překrytí nebo za špatných světelných podmínek.
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Julião, Sirlei Aparecida. "Avaliação da estabilidade genômica em acessos naturais e sintéticos de Lippia alba (MILL.) N. E. Br. (Verbenaceae)." Universidade Federal de Juiz de Fora (UFJF), 2017. https://repositorio.ufjf.br/jspui/handle/ufjf/6035.
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Lippia alba é uma espécie medicinal com ampla diversidade fenotípica, incluindo a composição do óleo essencial. A variação genética é provavelmente a principal causa dessa variação. A espécie foi descrita como um complexo poliploide com cinco números cromossômicos (2n=30, 38, 45, 60 e 90). Devido à importância econômica e à variação genética natural, essa espécie representa um excelente modelo em estudos sobre estabilidade genômica. Este trabalho teve como objetivo investigar a estabilidade genômica de 22 acessos naturais cultivados in vitro durante sete anos e em acessos poliploides sintéticos obtidos a partir da duplicação cromossômica de um acesso diploide natural usando colchicina. Para analisar a estabilidade do genoma de plantas cultivadas a longo prazo, foram analisadas quatro plantas (três mantidas in vitro e uma no campo) de 22 acessos. O tamanho do genoma foi verificado por citometria de fluxo e oito marcadores ISSR foram utilizados para verificara estabilidade em nível de sequencia de DNA. Para avaliar a estabilidade genômica após a poliploidização, onze plantas poliploides sintéticas, sendo 5 tetraploides (4X) e 6 mixoploides (2X / 4X) foram comparadas com a planta matriz diploide. As comparações foram baseadas no conteúdo de DNA, contagem cromossômica, marcadores moleculares ISSR e SSR e no perfil químico do óleo essencial. A comparação entre as plantas mantidas in vitro e as respectivas plantas mantidas no campo mostrou que 13 dos 22 acessos sofreram uma pequena redução no tamanho do genoma. Os marcadores ISSR detectaram polimorfismos na sequência de DNA variando de 1,61 a 33,87%. Somente três acessos não apresentaram bandas polimórficas. O número de bandas polimórficas entre os outros 19 acessos variou de um a 21. A análise da ploidia das plantas poliploides sintéticas realizada em folhas e raízes confirmou a estabilidade das plantas tetraploides. As plantas mixoploides apresentaram um único pico G1 correspondente a plantas triploides. A análise cromossômica revelou 60 cromossomos com 12 sítios de DNAr 45S nas plantas tetraploides e 9 sítios de DNAr 45S nos 45 cromossomos observados nas plantas triploides. Os marcadores ISSR mostraram polimorfismo entre a planta matriz diploide e as plantas poliploides sintéticas. A taxa de polimorfismo variou de 1,81 a 5,45% nas plantas tetraploides e de 43,63 a 56,36% nas plantas triploides. Alterações no tamanho dos alelos de microssatélites também foram detectadas. A planta matriz diploide apresentou dez alelos, três dos quais foram compartilhados com as plantas triploides e sete com as plantas tetraploides. Todas as plantas triploides apresentaram 13 alelos, sendo dez deles correspondentes a alelos novos. O número de alelos detectados nas plantas tetraploides variou de oito a 11 e o número de alelos novos como consequência da poliploidização variou de dois a quatro. O componente majoritário detectado no óleo essencial da planta matriz diploide e das plantas tetraploides foi o citral e nas plantas triploides foi o linalol. A instabilidade genômica detectada em L. alba após sete anos de cultura in vitro pode ser devido à consequência da instabilidade do genoma natural combinada com a cultura in vitro a longo prazo. Os efeitos da poliploidização que resultam em reorganização genômica e alterações fisiológicas podem explicar a variação observada nas plantas poliploides sintéticas.
Lippia alba is a medicinal species with a broad phenotypic diversity, including the essential oil composition. Genetic variation is probably the main cause of this variation. The species is a polyploid complex with five chromosome numbers (2n = 30, 38, 45, 60 and 90). Due to the economic importance and the natural genetic variation, this species represents an excellent model in studies on the genomic stability. This work aimed to investigate the genomic stability of 22 natural accessions grown in vitro for 7 years and in synthetic polyploid accessions obtained from the chromosome duplication of a natural diploid access using colchicine. To analyze the genome stability of long-term cultivated plants, four replicates (three maintained in vitro and one in the field) of 22 accessions were analyzed. The size of the genome was verified by flow cytometry and eight ISSR markers checked for stability in the DNA sequence. To evaluate the effect of polyploidization, eleven synthetic polyploid plants composed of 5 tetraploids (4X) and 6 mixoploids (2X/4X) were compared with the diploid parent plant. The comparisons were based on DNA content, chromosomal count, molecular markers ISSR and SSR, and chemical profile of the essential oil. The comparison between the plants maintained in vitro and the respective plants maintained in the field showed that 13 of the 22 accessions suffered a small reduction in the size of the genome. ISSR markers detected polymorphisms in the DNA sequence ranging from 1.61 to 33.87%. Only three accessions did not present polymorphic bands. The number of polymorphic bands among the other 19 accesses ranged from 1 to 21. Analysis of the ploidy of the synthetic polyploid plants carried out on leaves and roots confirmed the stability of the tetraploid plants. The mixoploid plants presented a single G1 peak corresponding to triploid plants. The chromosome analysis showed 60 chromosomes with twelve 45S rDNA sites in the synthetic tetraploids and nine 45S rDNA sites over the 45 chromosomes observed in the synthetics triploid plants. ISSR markers showed polymorphism between the diploid parent plant and synthetic polyploid plants. The polymorphism rate varied from 1.81 to 5.45% in the tetraploid plants and from 43.63 to 56.36% in the triploid plants. Changes in the size of the microsatellite alleles were also detected. The diploid parental plant presented 10 alleles, of which 3 were shared with the triploid plants and 7 with the tetraploid plants. All triploid plants had 13 alleles, 10 of which correspond to new alleles. The number of alleles detected in tetraploid plants ranged from 8 to 11 and the number of new alleles as a consequence of polyploidization ranged from 2 to 4. The major component detected in the essential oil of the parental diploid plant and the tetraploid plants was the citral and the triploid plants was the linalool. The genetic instability detected in L. alba after seven years of in vitro culture may be due to the consequence of natural genome instability combined with long-term in vitro culture. The effects of polyploidization that result in genomic reorganization and physiological changes may explain the variation observed in synthetic polyploid plants.
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Gugler, Klaus, and Florian Szücs. "Merger externalities in oligopolistic markets." Elsevier, 2016. http://epub.wu.ac.at/5727/1/Gugler_Sz%C3%BCcs_2016_Merger%2Dexternalities_spillover_IJIO_rev2.pdf.
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We evaluate the external effects of 183 large mergers at the market level by assessing the impact on the main competitors of the merging firms. Using synthetic control groups and difference in difference estimation, we find that the return on assets of rival firms increases significantly after a merger. The size of the effect varies strongly with market characteristics and the intensity of competition.
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Mason, Brenden James. "The Effects of Options Markets on the Underlying Markets: Quasi-Experimental Evidence." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/503097.
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EconomicsPh.D.
This dissertation consists of three essays in applied financial economics. The unifying theme is the use of financial regulation as quasi-experiments to understand the interrelationship between derivatives and the underlying assets. The first two essays use different quasi-experimental econometric techniques to answer the same research question: how does option listing affect the return volatility of the underlying stock? This question is difficult to answer empirically because being listed on an options exchange is not random. Volatility is one of the dimensions along which the options exchanges make their listing decisions. This selection bias confounds any causal effect that option listing may have. What is more, the options exchanges may list along unobservable dimensions. Such omitted variable bias can also confound any causal effect of option listing. My first essay overcomes these two biases by exploiting the exogenous variation in option listing that is created by the SEC-imposed option listing standards. Specifically, the SEC mandates that a stock must meet certain criteria in the underlying market before it can trade on an options exchange. For example, a stock needs to trade a total of 2.4 million shares over the previous 12 months before it can be listed. Since 2.4 million is an arbitrary number, stocks that are “just above” the 2.4 million threshold will be identical to stocks that are “just below” it, the sole difference being their probability of option listing. Accordingly, I use the 2.4 million threshold as an instrument for option listing in a fuzzy regression discontinuity design. I find that option listing causes a modest decrease in underlying volatility, a result that corroborates many previous empirical studies. My second essay attempts to estimate the effect of option listing for stocks that are “far away from” the 2.4 million threshold. I overcome the aforementioned omitted variable bias by fully exploiting the panel nature of the data. I control for the unobserved heterogeneity across stocks by implementing a two-way fixed effects model. Unlike most previous studies, I control for individual-level fixed effects at the firm level rather than at the industry level. My results show that option listing is associated with a decrease in volatility. Importantly, these results are only statistically significant in a model with firm-level fixed effects; they are insignificant with industry-level fixed effects. My third essay is a policy evaluation of the SEC’s Penny Pilot Program, a mandated decrease of the option tick size for various equity options classes. Several financial professionals claimed that this decrease would drive institutional investors out of the exchange-traded options market, channeling them into the opaque, over-the-counter (OTC) options market. I empirically test an implication of this hypothesis: if institutional investors have fled the exchange-traded options market for the OTC market, then it may take longer for information to be impounded into a stock’s price. Using the `price delay’ measure of Hou and Moskowitz (2005), I test whether stocks become less price efficient as a result of being included in the Penny Pilot Program. I perform this test using firm-level fixed effects on all classes that were included in the program. I confirm these results with synthetic control experiments for the classes included in Phase I of the Penny Pilot Program. Generally, I find no change in price efficiency of the underlying stocks, which suggests that the decrease in option tick size did not materially erode the price discovery that takes place in the exchange-traded equity options market. I also find evidence that the decrease in option tick size caused an increase in short selling for the piloted stocks.
Temple University--Theses
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Sutherland, Robert John Davidson. "Internal and external labour markets : a synthetic approach." Thesis, Leeds Beckett University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324517.
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The elevenp apersa ssociatedw ith this submissionre flect a researchp rogrammeth at has as its centralc onceptualf rameworka synthesiso f the traditionally competing perspectiveosf the 'externalla bour market'andt he 'internall abourm arketýT he Holt and David 'stock! and 'flow' model of the former is integrated with Doeringer and Piore'sm odelo f labour allocationa nd utilisation within the organisationto createa 'syntheticp aradigmt!h at offers, it is argued,a moreh olistic insighti nto the operation of labour markets.O ne especialc onsequenceo f the use of this paradigm is the opening up of the 'black box! that is the f= in much of the traditional labour economics literature. Not only are policies of company recruitment and selection transformedto becomee ssential,in tegral elementsw ithin the researchp rogramme, the externall abourm arketc onsequenceosf thesep oliciesa re seent o havei mportant implications for the identification and analysis of 'problems' of the external labour market. For purposes of the introductory, synthesising chapter, the eleven papers are subdivided into three themes. After an essential, preliminary quasi-ideological discussion of the role of perspectives in the literature pertaining to labour markets, the subsequent, predominantly empirical papers focus upon two aspects of the interrelationships between internal and external labour markets viz. engagements i. e. flows, principally from the external labour market, into organisations; and separations ie. flows from organisations, principally but not exclusively to, the external labour market. The synthesising chapter demonstrates - and the accompanying papers evidence - both the viability and the efficacy of the 'synthetic paradigm! and illustrates the additional insights into the problems and policies of employment and Iabour markets which accrue from its application.
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Rumble, Tony Law Faculty of Law UNSW. "Synthetic equity and franked debt: capital markets savings cures." Awarded by:University of New South Wales. School of Law, 1998. http://handle.unsw.edu.au/1959.4/17591.
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Micro-economic reform is a primary objective of modern Australian socio-economic policy. The key outcome targetted by this reform is increased efficiency, measured by a range of factors, including cost reduction, increased savings, and a more facilitative environment for business activity. These benefits are sought by the proponents of reform as part of a push to increase national prosperity, but concerns that social equity is undermined by it are expressed by opponents of that reform. The debate between efficiency and equity is raging in current Australian tax policy, a key site for micro-economic reform. As Government Budget restructuring occurs in Australia, demographic change (eg, the ageing population) undermines the ability of public funded welfare to provide retirement benefits. Responsibility for self-funded retirement is an important contributor to increasing private savings. Investment in growth assets such as corporate stock is increasing in Australia, however concerns about volatility of asset values and yield stimulate the importance of investment risk management techniques. Financial contract innovation utilising financial derivatives is a dominant mechanism for that risk management. Synthetic equity products which are characterised by capital protection and enhanced yield are popular and efficient equity risk management vehicles, and are observed globally, particularly in the North American market. Financial contract innovation, risk management using financial derivatives, and synthetic equity products suffer from an adverse tax regulatory response in Australia, which deprives Australian investors from access to important savings vehicles. The negative Australian tax response stems from anachronistic legislation and jurisprudence, which emphasises tax outcomes based on legal form. The pinnacle of this approach is the tax law insistence on characterisation of financial contracts as either debt or equity, despite some important financial similarities between these two asset types. Since derivatives produce transactions with novel legal forms this approach is unresponsive to innovation. The negative tax result also stems from a perception that the new products are tax arbitrage vehicles, offering tax benefits properly available to investment in stocks, which is thought to be inappropriate when the new products resemble debt positions (particularly when they are capital protected and yield enhanced). The negative tax response reflects administrative concerns about taxpayer equity and revenue leakage. This approach seeks to impose tax linearity by proxy: rather than utilising systemic reform to align the tax treatment of debt and equity, the current strategy simply denies the equity tax benefits to a variety of innovative financial contracts. It deprives Australians of efficiency enhancing savings products, which because of an adverse tax result are unattractive to investors. The weakness of the current approach is illustrated by critical analysis of three key current and proposed tax laws: the ???debt dividend??? rules in sec. 46D Income Tax Assessment Act 1936 (the ???Tax Act???); the 1997 Budget measures (which seek to integrate related stock and derivative positions); and the proposals in the Taxation of Financial Arrangements Issues Paper (which include a market value tax accounting treatment for ???traded equity,??? and propose a denial of the tax benefits for risk managed equity investments). The thesis develops a model for financial analysis of synthetic equity products to verify the efficiency claims made for them. The approach is described as the ???Tax ReValue??? model. The Tax ReValue approach isolates the enhanced investment returns possible for synthetic equity, and the model is tested by application to the leading Australian synthetic equity product, the converting preference share. The conclusions reached are that the converting preference share provides the key benefits of enhanced investment return and lower capital costs to its corporate issuer. This financial efficiency analysis is relied upon to support the assertion that a facilitative tax response to such products is appropriate. The facilitative response can be delivered by a reformulation of the existing tax rules, or by systemic reform. The reformulation of the existing tax rules is articulated by a Rule of Reason, which is proposed in the thesis as the basis for the allocation and retention of the equity tax benefits. To avoid concerns about taxpayer equity and revenue leakage the Rule of Reason proposes a Two Step approach to the allocation of the equity tax benefits to synthetics. The financial analysis is used to quantify non-tax benefits of synthetic equity products, and to predict whether and to what extent the security performs financially like debt or equity. This financial analysis is overlayed by a refined technical legal appraisal of whether the security contains the essential legal ???Badges of Equity.??? The resulting form and substance approach provides a fair and equitable control mechanism for perceived tax arbitrage, whilst facilitating efficient financial contract innovation. The ultimate source of non-linearity in the taxation of investment capital is the differential tax benefits provided to equity and debt. To promote tax linearity the differentiation needs to be removed, and the thesis makes recommendations for systemic reform, particularly concerning the introduction of a system of ???Franked Debt.??? The proposed system of ???Franked Debt??? would align the tax treatment of debt and equity by replacing the corporate interest deduction tax benefit with a lender credit in respect of corporate tax paid. This credit would operate mechanically like the existing shareholder imputation credit. The interface of this domestic tax credit scheme with the taxation of International investment capital, and the problems occasioned by constructive delivery of franking credits to Australian taxpayers via synthetics, are resolved by the design and costings of the new system, which has the potential to be revenue positive.
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Riley, Richard David. "Evidence synthesis of prognostic marker studies." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/30480.
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Passmore, Sarah Louise. "Synthesis and evaluation of redox-activated prodrug delivery systems as biological markers." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495597.
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Benzoquinone-based tripartite prodrug delivery systems have been developed to selectively release an active drug under biological conditions. The make-up of the'tripartita delivery asystem is a trigger moiety (quinone) attached to a linker unit (propanoic acid) This is then attached to the active drug via an ester (or amide) link effectively rendering the drug inactive. The aim of this work was to design, synthesise and evaluate a select ct series of prodrug systems and to ascertain whether varying the substituents on the quinone and linker units would enhance the activation of the prodrug and the release of the active ive species following chemical or enzymatic activation.
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Staveren, Dave Richard van. "Robust transition metal markers for labelling of peptides via solid phase synthesis methods." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962393665.
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Nxusani, Ezo. "Synthesis and analysis of Novel Platinum group Metal Chalcogenide Metal Quantum Dot and Electrochemical Markers." University of the Western Cape, 2018. http://hdl.handle.net/11394/6424.
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Magister Scientiae - MSc (Chemistry)Although cadmium and lead chalcogenide quantum dot have excellent optical and photoluminescent properties that are highly favorable for biological applications, there still exists increasing concerns due to the toxicity of these metals. We, therefore, report the synthesis of new aqueous soluble IrSe quantum dot at room temperature utilizing a bottom-up wet chemistry approach. NaHSe and H2IrCl6 were utilized as the Se and Ir source, respectively. High-resolution transmission electron microscopy reveals that the synthesized 3MPA-IrSe Qd are 3 nm in diameter. The characteristics and properties of the IrSe Qd are investigated utilizing, Selected Area electron diffraction, ATR- Fourier Transform Infra-Red Spectroscopy, Energy Dispersive X-ray spectroscopy, Photoluminescence, Cyclic Voltammetry and chronocoulometry. A 3 fold increase in the optical band gap of IrSe quantum dot in comparison to reported bulk IrSe is observed consistent with the effective mass approximation theory for semiconductor materials of particles sizes < 10 nm. The PL emission of the IrSe quantum dot is at 519 nm. Their electro-activity is studied on gold electrodes and exhibit reduction and oxidation at - 107 mV and +641 mV, with lowered reductive potentials. The synthesized quantum dot are suitable for low energy requiring electrochemical applications such as biological sensors and candidates for further investigation as photoluminescent biological labels.
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Brabez, Nabila. "Design, Synthesis and Study of Novel Multivalent Ligands - Toward New Markers of Cancer Cells." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/238691.
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Cancer is lacking early detection methods and treatment specificity. In order to increase the sensitivity and specificity towards cancer cells, we propose the use of multivalent interactions targeting specific receptor combinations at the cancer cell surface. In this thesis, we explored the design of multimers, which could provide such interactions. The design was investigated and revisited based on specific parameters, essential for the creation of multivalent interactions such as thermodynamics. The synthesis was designed so that libraries of homo- and hetero-multimers of different valencies can be obtained efficiently with good yields. The established synthetic scheme is empowered by its modularity, necessary to investigate different essential factors. Trimers composed of micromolar affinity MSH(4) targeting the MC1-R, overexpressed in melanoma, were investigated on a model cell line and resulted in the creation of nanomolar affinity constructs with up to 350 fold increase in affinity. Different multimers such as hexavalent and nonavalent dendrimers were synthesized and studied for their properties. All constructs had nanomolar affinity and showed to be non-toxic up to micromolar concentrations and imaging studies also confirmed their internalization, which overall demonstrate the potential for these compounds to be used as markers for cancer cells and as delivery agents. Trimers targeting the CCK2-R were similarly investigated for their potential as pancreatic cancer markers. However, those constructs did not seem to result in the expected enhancements in affinity, but the affinity of the initial monovalent agonist was in the 10-50 nanomolar range. As we were unable to design micromolar affinity agonist we investigated the use of antagonists. This study, revealed the importance of thermodynamics in the creation of multivalent interaction. Heterotrivalent ligands (CCK and MSH) were investigated for their potential in cross-linking different receptors and the study demonstrated the subtility to detect cross-linking. Finally, the different attempts toward the efficient synthesis of a tetra-orthogonal scaffold, a key feature needed to generate multimers that could target up to 3 different receptors was investigated and showed promising results. It is our hypothesis that such an approach will ultimately lead to specific markers of tumor cells, which could be used as diagnosis agents when modified with an imaging moiety and as a therapeutic agent when modified with a drug.
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Ahn, Jae-Wan. "Three Essays on Housing Markets, Urban Land Use, and the Environment." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555457869257077.
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Badreldin, Ahmed [Verfasser], and Bernhard [Akademischer Betreuer] Nietert. "Asset Pricing on Segmented Markets: A Synthesis, an Extension and an Application to Islamic Financial Markets / Ahmed Badreldin ; Betreuer: Bernhard Nietert." Marburg : Philipps-Universität Marburg, 2018. http://d-nb.info/1155533623/34.
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Baldridge, Anthony Owen. "Synthesis, photophysics, and application of fluorescent protein chromophore analogs." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/44744.
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The green fluorescent protein chromophore exhibits remarkably different properties upon removal from the protective beta-barrel. This work focuses on the synthesis of these chromophores as wells studying the photophysics as to why they readily deactivate. Following these initial discoveries, these chromophores can be applied to many different environments providing a fluorescence "turn-on" and thus proving to be applicable in a number of different environments and fields.
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Noseworthy, Dianne. "Depositional evolution and structural synthesis of the B marker (limestone) member, Whiterose formation, Jeanne d'Arc, offshore Newfoundland /." Internet access available to MUN users only, 2003. http://collections.mun.ca/u?/theses,61788.
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Nakano, Yukie. "An evaluation of the potential for wider use of recycled synthetic materials in the UK High Street clothing markets : its drivers and barriers." Thesis, Northumbria University, 2010. http://nrl.northumbria.ac.uk/492/.
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This thesis focuses on the potential to expand the markets for recycled synthetic materials, specifically focusing on the uptake of polyester recycling technologies and materials from the perspective of UK high street clothing retailers and Japanese recycled polyester textile manufacturers. Historically, textile waste or 'shoddy' has been 'downcycled' and used in products such as blankets, rugs or wipers. During the 1990s technological developments enabled the production of thinner and longer fibres from recycled polyester for clothing, particularly in outdoor wear, sportswear and uniforms. Advances in chemical recycling systems which return the fibre to its original raw materials state have led to the production of fibres of a quality equal to those produced from virgin material. Polyester is currently the only viable material which can be 'upcycled' and used in 'closed loop recycling systems'. This research investigated the barriers and drivers affecting the adoption of recycled polyester in high street clothing markets, from the perspectives of UK high street clothing retailers, UK consumers, and world leading Japanese recycled polyester textile manufacturers. The study is exploratory in nature, and comprises a literature review, a street survey and industry surveys. The literature review was carried out in order to understand current thinking in the areas of sustainable fashion and technological development, particularly with regards to the production of recycled polyester. A street survey conducted in Newcastle gathered information from the general public in order to evaluate consumer attitudes towards clothes with recycled content, what affects their purchasing decisions when buying clothes, and their awareness of recycled clothing products in the market. The industry surveys were adopted to examine the views of five major recycled polyester fibre and fabric manufacturers in Japan and evaluate their perspectives on the potential for recycled polyester outside their current niche markets. Four major UK high street clothing retailers were interviewed in order to gain insights into their current practices for product development (in particular the materials selection process), to evaluate the level of environmental consideration they have when they develop products, and to test their readiness to use recycled materials. The findings are derived from previously unscrutinised barriers and drivers for the wider use of recycled synthetic materials in high street clothing retailers. Two key factors are identified: Japanese manufacturers need to create 'closed loop' recyclable synthetic fabrics that have excellent tactile and design qualities to appeal to the teams that source fabrics for clothing development. Clothing retailers need torecognise that it is possible to specify 'closed loop' fabrics but they need to connect this to clear design, business and sustainable development strategies. The contribution of this thesis based on the findings shows the potential to extend the recycled polyester market, based on advanced technology and socioeconomical issues, the outlook of recycled textile producers, and public opinion towards clothes with recycled content. The key recommendation concerns the need to establish a long term commitment between clothing retailers and recycled fabric producers in order to develop desirable recycled fabrics for general and fashion markets. Further research is suggested on this basis.
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Mabhena, Rejoice. "An application of synthetic panel data to poverty analysis in South Africa." Thesis, University of the Western Cape, 2019. http://hdl.handle.net/11394/7801.
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Doctor EducationisThere is a wide-reaching consensus that data required for poverty analysis in developing countries are inadequate. Concerns have been raised on the accuracy and adequacy of household surveys, especially those emanating from Sub-Saharan Africa. Part of the debate has hinted on the existence of a statistical tragedy, but caution has also been voiced that African statistical offices are not similar and some statistical offices having stronger statistical capacities than others. The use of generalizations therefore fails to capture these variations. This thesis argues that African statistical offices are facing data challenges but not necessarily to the extent insinuated. In the post-1995 period, there has been an increase in the availability of household surveys from developing countries. This has also been accompanied by an expansion of poverty analyses efforts. Despite this surge in data availability, available household survey data remain inadequate in meeting the demand to answer poverty related enquiry. What is also evident is that cross sectional household surveys were conducted more extensively than panel data. Resultantly the paucity of panel data in developing counties is more pronounced. In South Africa, a country classified as ‘data rich’ in this thesis, there exists inadequate panel surveys that are nationally representative and covers a comprehensive period in the post-1995 period. Existing knowledge on poverty dynamics in the country has relied mostly on the use of the National Income Dynamic Study, KwaZulu Natal Dynamic Study and smaller cohort-based panels such as the Birth to Twenty and Birth to Ten cohort studies that have rarely been used in the analysis of poverty dynamics. Using mixed methods, this thesis engages these data issues. The qualitative component of this thesis uses key informants from Statistics South Africa and explores how the organization has measured poverty over the years. A historical background on the context of statistical conduct in the period before 1995 shows the shaky foundation that characterised statistical conduct in the country at the inception of Statistics South Africa in 1995. The organization since then has expanded its efforts in poverty measurement; partly a result of the availability of more household survey data. Improvements within the organization also are evidenced by the emergence of a fully-fledged Poverty and Inequality division within the organization. The agency has managed to embrace the measurement of multidimensional poverty. Nevertheless, there are issues surrounding xv available poverty related data. Issues of comparability affect poverty analysis, and these are discussed in this thesis. The informants agreed that there is need for more analysis of poverty using available surveys in South Africa. Against this backdrop, the use of pseudo panels to analyse poverty dynamics becomes an attractive option. Given the high costs associated with the conduct of panel surveys, pseudo panels are not only cost effective, but they enable the analysis of new research questions that would not be possible using existing data in its traditional forms. Elsewhere, pseudo panels have been used in the analysis of poverty dynamics in the absence of genuine panel data and the results have proved their importance. The methodology used to generate the pseudo panel in this thesis borrows from previous works including the work of Deaton and generates 13 birth cohorts using the Living Conditions Surveys of 2008/9 and 2014/15 as well as the IES of 2010. The birth cohorts under a set of given assumptions are ‘tracked’ in these three time periods. The thesis then analysed the expenditure patterns and poverty rates of birth cohorts. The findings suggested that in South Africa, expenditures are driven mostly with incomes from the labour market and social grants. The data however did not have adequate and comparative variables on the types of employment to further explore this debate. It also emerged that birth cohorts with male headship as well as birth cohorts in urban settlements and in White and Indian households have a higher percentage share of their income coming from labour market sources. On the other hand, birth cohorts with female headship and residing in rural, African and in Coloured households are more reliant on social grants. The majority of recipients of social grants receive the Child Social Grant and its minimalist value partly explains why birth cohorts reporting social grants as their main source of income are more likely to be poor when compared to birth cohorts who mostly earn their income from the labour market. Residing in a female-headed household, or in a rural area as well as in Black African and Coloured increases the chances of experiencing poverty. This supports existing knowledge on poverty in South Africa and confirms that these groups are deprived. The results of the pseudo panel analysis also show that poverty reduced between 2006 and 2011 for most birth cohorts but increased in 2015. Policy recommendations to reduce poverty therefore lie in the labour market. However, given the high levels of unemployment in the country today, more rigorous labour incentives are required.
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Meunier, Bogdan. "Complexity, diplomatic relationships and business creation : a cross-regional analysis of the development of productive knowledge, trade facilitation and firm entry in regional markets." Thesis, Paris 1, 2019. http://www.theses.fr/2019PA01E001/document.
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Cette thèse adopte une approche analytique interrégionale de trois régions économiques pour évaluer les connaissances productives et la diplomatie dans le contexte d’intégration régionale, et en parallèle, les déterminants de la création d'entreprises. Du point de vue de l'intégration européenne, nous introduisons une nouvelle méthodologie de contrôle synthétique pour évaluer l'impact de l'adhésion à l'UE sur l'indice de complexité économique des nouveaux États membres d'Europe centrale et orientale. Nos résultats indiquent que l'adhésion à l'UE a joué un rôle catalyseur pour la connaissance productive des pays portant de faibles niveaux de complexité avant l'adhésion, permettant un taux de développement plus élevé dans la sophistication de l'espace d'exportation de leurs produits. En élargissant notre analyse à tous les pays européens et aux États d’Afrique du Nord, nous procédons dans un deuxième temps à l’analyse des déterminants du commerce des infrastructures institutionnelles et logistiques en élargissant le modèle de Gravité pour y incorporer des éléments de diplomatie (notamment la présence d’ambassades et d’ambassadeurs). Nos résultats démontrent les avantages des infrastructures immatérielles et matérielles ainsi que de l'activité diplomatique sur le commerce bilatéral des PECO et de l'Afrique du Nord, confirmant l'importance de ces variables en tant que moteurs de l'intégration régionale. Dans une dernière partie, nous concentrons notre analyse sur Fédération de Russie en tant que région géographique en introduisant une régression panel des déterminants de l’entrée et de la sortie d’entreprises. Cette évaluation empirique conclut que les défaillances institutionnelles et l’environnement politico-économique ont des effets significatifs sur la création et la destruction d’entreprises russes, avec une estimation robuste du prix mondial du pétrole (quelle que soit la différence entre les régions cibles) suggérant une forte exposition de chaque région russe à une crise mondialeThis thesis takes a cross-regional analytical approach of three distinct economic areas to evaluate productive knowledge and diplomacy in the context of regional integration alongside determinants of business creation. From the angle of European integration, we introduce a new synthetic control methodology to evaluate the impact of EU accession on the economic complexity index of new CEE member states its results indicating that accession to the EU acted as a catalyst for the productive knowledge of countries with low levels of complexity before accession, allowing a higher rate of development in the sophistication of their product export space. Expanding our analysis to include all European countries and North African states, we proceed in a second stage to analyse institutional and logistical infrastructure determinants of trade by extending the traditional Gravity model to incorporate elements of diplomacy (including the presence of embassies and ambassadors). Our results demonstrate the benefits of soft and hard infrastructure as well as diplomatic activity on the bilateral trade fixed effect CEE and North African countries, validating their importance of these variables as powerful drivers of regional integration. In a final part, we turn our analysis to the Russian Federation as a regional geography with a panel regression analysis of the determinants of firm entry and exit. The empirical evaluation concludes that institutional failures and the politico-economic environment exhibit statistically significant and economically meaningful effects both on the creation and destruction of Russian firms, with a robust estimate of the world oil price (irrespective of the difference in target regions) suggesting a possible high exposure of each Russian region to a global crisis
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Ferreira, Carlos Eduardo Martins. "Performativity and pluralities of biodiversity offsetting experiments : towards a synthesis of economy as instituted process and economy as performativity." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/performativity-and-pluralities-of-biodiversity-offsetting-experiments-towards-a-synthesis-of-economy-as-instituted-process-and-economy-asperformativity(420f27c6-55a4-480d-813f-f58c1d1f11e7).html.
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Development and land use change diminish the quantity of natural habitat, impacting negatively on the number of animal and plant species – biodiversity. Concern about the consequences of these losses has led to calls for mechanisms which allow development to proceed only when no net loss of biodiversity can be assured, such as biodiversity offsets. Markets for biodiversity offsets are being tried as mechanisms for achieving this societal objective in the most efficient manner possible. Theoretically, this thesis develops a framework connecting the Polanyi-inspired notion of the economy as an instituted process, and concepts developed by Callon and colleagues in the Social Studies of Finance literature. This framework is used to analyse the emergence, development and expansion of markets for biodiversity offsets. Using qualitative methodologies, the research examines in detail three existent biodiversity offset markets: Species Banking (United States), Impact Mitigation Regulations (Germany) and Biodiversity Offsets (England). The emergence of markets for biodiversity offsets is shown to be the result of performativity of economics. Changing representations of biodiversity, anchored on economic sciences, lead to policies which create economic experiments, such as markets for biodiversity offsets. Because these markets are historical and geographically contingent, the economic experiments emerge in the context of preexisting regulations and traditions, resulting in variety of forms of organising biodiversityoffset markets. To bring biodiversity to the market involves measuring and quantifying externalities. This requires the creation and development of market agencements – assemblages of agents and market devices – to commodify biodiversity. These agencements constitute the technical infrastructures upon which the markets are built, but they too are contingent of pre-market practice. This creates tensions between the role of agents and the role of devices inside the market infrastructure. Biodiversity offsets are shown to not maintain their commodity status beyond certain geographical and geopolitical boundaries. The result is the creation of mutually exclusive market nodes, between which no trade takes place. Despite common origins and infrastructures, the local markets do not exchange between themselves. This thesis contributes a framework for the analysis of market emergence, in which two literatures are used to complement each other’s limitations. As a result, the thesis is able to conceptualise how a common generative mechanism results in variety of economic organisation. It also demonstrates that it is possible for markets to share a regulatory and technical infrastructure, but not exchange between themselves and expand.
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Wolf, Christopher Alexander. "Case Histories and Analyses of Synthetic Economies: Implications for Experiments, Game Design, Monetization, and Revenue Maximization." Kent State University Honors College / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1368095911.
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Ferreira, Maria Pontes Kreider Richard B. Willoughby Darryn Scott. "Effects of ingesting carbohydrate and branched-chain amino acids on markers of skeletal muscle protein synthesis of the insulin-PI3K-mTOR signal transduction pathways in response to a bout of heavy resistance exercise." Waco, Tex. : Baylor University, 2008. http://hdl.handle.net/2104/5230.
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PAGANINI, PAULA P. "Síntese e caracterização de nanopartículas de óxido misto de estanho/titânio dopadas com lantanídeos para marcação biológica." reponame:Repositório Institucional do IPEN, 2012. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10182.
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Made available in DSpace on 2014-10-09T12:35:42Z (GMT). No. of bitstreams: 0Made available in DSpace on 2014-10-09T14:03:56Z (GMT). No. of bitstreams: 0
Tese (Doutoramento)
IPEN/T
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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Johansson, Maria. "Improved Energy Efficiency and Fuel Substitution in the Iron and Steel Industry." Doctoral thesis, Linköpings universitet, Energisystem, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-105849.
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IPCC reported in its climate change report 2013 that the atmospheric concentrations of the greenhouse gases (GHG) carbon dioxide (CO2), methane, and nitrous oxide now have reached the highest levels in the past 800,000 years. CO2 concentration has increased by 40% since pre-industrial times and the primary source is fossil fuel combustion. It is vital to reduce anthropogenic emissions of GHGs in order to combat climate change. Industry accounts for 20% of global anthropogenic CO2 emissions and the iron and steel industry accounts for 30% of industrial emissions. The iron and steel industry is at date highly dependent on fossil fuels and electricity. Energy efficiency measures and substitution of fossil fuels with renewable energy would make an important contribution to the efforts to reduce emissions of GHGs. This thesis studies energy efficiency measures and fuel substitution in the iron and steel industry and focuses on recovery and utilisation of excess energy and substitution of fossil fuels with biomass. Energy systems analysis has been used to investigate how changes in the iron and steel industry’s energy system would affect the steel plant’s economy and global CO2 emissions. The thesis also studies energy management practices in the Swedish iron and steel industry with the focus on how energy managers think about why energy efficiency measures are implemented or why they are not implemented. In-depth interviews with energy managers at eleven Swedish steel plants were conducted to analyse energy management practices. In order to show some of the large untapped heat flows in industry, excess heat recovery potential in the industrial sector in Gävleborg County in Sweden was analysed. Under the assumptions made in this thesis, the recovery output would be more than three times higher if the excess heat is used in a district heating system than if electricity is generated. An economic evaluation was performed for three electricity generation technologies for the conversion of low-temperature industrial excess heat. The results show that electricity generation with organic Rankine cycles and phase change material engines could be profitable, but that thermoelectric generation of electricity from low-temperature industrial excess heat would not be profitable at the present stage of technology development. With regard to fossil fuels substituted with biomass, there are opportunities to substitute fossil coal with charcoal in the blast furnace and to substitute liquefied petroleum gas (LPG) with bio-syngas or bio synthetic natural gas (bio-SNG) as fuel in the steel industry’s reheating furnaces. However, in the energy market scenarios studied, substituting LPG with bio-SNG as fuel in reheating furnaces at the studied scrap-based steel plant would not be profitable without economic policy support. The development of the energy market is shown to play a vital role for the outcome of how different measures would affect global CO2 emissions. Results from the interviews show that Swedish steel companies regard improved energy efficiency as important. However, the majority of the interviewed energy managers only worked part-time with energy issues and they experienced that lack of time often was a barrier for successful energy management. More efforts could also be put into engaging and educating employees in order to introduce a common practice of improving energy efficiency at the company.Halterna av växthusgaserna koldioxid (CO2), metan och kväveoxider har under de senaste 800 000 åren aldrig varit högre i atmosfären än vad de är idag. Detta resultat redovisades i IPCCs klimatrapport år 2013. CO2-koncentrationen har ökat med 40 % sedan förindustriell tid och denna ökning beror till största delen på förbränning av fossila bränslen. Ökade koncentrationer av växthusgaser leder till högre global medeltemperatur vilket i sin tur resulterar i klimatförändringar. För att bromsa klimatförändringarna är det viktigt att vi arbetar för att minska utsläppen av växthusgaser. Industrin står för 20 % av de globala utsläppen av CO2 och järn- och stålindustrin står för 30 % av industrins utsläpp. Järn- och stålindustrin är i dag till stor del beroende av fossila bränslen och el för sin energiförsörjning. Energieffektiviseringsåtgärder och byte av fossila bränslen mot förnybar energi i järn- och stålindustrin skulle kunna bidra till minskade utsläpp av växthusgaser. Denna avhandling studerar åtgärder för effektivare energianvändning och möjligheter för bränslebyte i järn- och stålindustrin. Avhandlingen fokuserar på återvinning och utnyttjande av överskottsenergier och ersättning av fossila bränslen med biomassa. Energisystemanalys har använts för att undersöka hur förändringar i järn- och stålindustrins energisystem skulle påverka ekonomin och de globala utsläppen av CO2. Avhandlingen studerar också betydelsen av energiledning och nätverkande för att uppnå en effektivare energianvändning. Fokus har här varit på att studera hur energiansvariga resonerar kring varför energieffektiviseringsåtgärder genomförs eller varför de inte genomförs. Djupintervjuer med energiansvariga vid elva svenska stålverk genomfördes för att analysera denna fråga. För att ge ett exempel på den stora outnyttjade potentialen av överskottsvärme från industrin analyserades potentialen i Gävleborgs län. Möjligheterna att använda överskottsvärmen som fjärrvärme eller för att producera el analyserades. Här visar resultaten att fjärrvärmeproduktionen skulle bli mer än tre gånger så stor som elproduktionen. En ekonomisk utvärdering gjordes där tre tekniker för produktion av el från lågtempererad industriell överskottsvärme jämfördes. Resultaten visar att elproduktion med organisk Rankine-cykel eller en så kallad fasändringsmaterialmotor kan vara lönsam, men att termoelektrisk elproduktion inte är lönsam med dagens teknik och prisnivåer. Det är möjligt att ersätta en del av det fossila kolet i masugnen med träkol och på detta sätt introducera förnybar energi i stålindustrin. Man kan också ersätta gasol som används som bränsle i stålindustrins värmningsugnar med syntesgas eller syntetisk naturgas (SNG) som produceras genom förgasning av biomassa. Under de antaganden som gjorts i avhandlingen skulle det dock inte vara lönsamt för det skrotbaserade stålverk som studerats att ersätta gasolen med bio-SNG. För att uppnå lönsamhet behövs i detta fall ekonomiska styrmedel. Hur olika åtgärder påverkar de globala utsläppen av CO2 beror till stor del på hur framtidens energimarknad ser ut. Elproduktion från industriell överskottsvärme skulle minska de globala CO2-utsläppen i alla scenarier som studerats, men för de andra åtgärderna varierar resultaten beroende på vilka antaganden som gjorts. Resultaten från intervjustudien visar att svensk stålindustri anser att energifrågan är viktig, men det finns fortfarande mycket att göra för att effektivisera energianvändningen i denna sektor. Flera av de intervjuade arbetade bara deltid med energifrågor och de upplevde att tidsbrist hindrade dem från ett effektivt energiledningsarbete. En rekommendation till företagen är därför att anställa en energiansvarig på heltid och/eller fler personer som kan arbeta med energifrågor. Det bör också läggas mer resurser på att engagera och utbilda anställda för att på så sätt introducera en företagskultur som främjar effektiv energianvändning.
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Thinnes, Cyrille Christophe. "Chemical and biological studies on human oxygenases." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:455f2e65-f294-461b-b44f-cd53796b14a0.
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As depicted in Chapter I, 2-oxoglutarate- (2OG) dependent oxygenases are ubiquitous in living systems and display a wide range of cellular functions, spanning metabolism, transcription, and translation. Although functionally diverse, the 2OG oxygenases share a high degree of structural similarities between their catalytic sites. From a medicinal chemistry point of view, the combination of biological diversity and structural similarity presents a rather challenging task for the development of selective small molecules for functional studies in vivo. The non-selective metal chelator 8-hydroxyquinoline (8HQ) was used as a template for the generation of tool compound I for the KDM4 subfamily of histone demethylases via application of the Betti reaction. Structural analogue II was used as the corresponding negative control (Figure A). These compounds were characterised in vitro against a range of 2OG oxygenases and subsequently used for studies in cells. I displays selectivity for KDM4 and increases the level of the H3K9me3 histone mark in cells. It has an effect on the post-translational modification pattern of histone H3, but not other histones, and reduces the viability of lung cancer cells, but not normal lung cells, derived from the same patient. I also stabilises hypoxia-inducable factor HIF in cells via a mechanism which seems to be independent from prolyl hydroxylase inhibition. This work is described in Chapters II and III. The chemical biology research in epigenetics is complemented by qualitative analysis conducted in the social sciences at Said Business School. With a global view on how innovation occurs and may actively be fostered, Chapter IV focuses on the potential of epigenetics in drug discovery and how this process may actively be promoted within the framework of open innovation. Areas of focus include considerations of incremental and disruptive technology; how to claim, demarcate, and control the market; how knowledge brokering occurs; and insights about process, management, organisation, and culture of open innovation. In contrast to the open-skies approach adopted for the development of a tool compound in Chapters II and III, a focused-library approach was taken for the generation of a tool compound for the OGFOD1 ribosomal prolyl hydroxylase. The development of a suitable in vitro activity assay for OGFOD1 in Chapter V enabled the development of lead compound III in Chapter VI. III is selective for OGFOD1 against the structurally closely related prolyl hydroxylase PHD2.
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Pfeffer, Inga. "Interplay between 2-oxoglutarate oxygenases and cancer : studies on the aspartyl/asparaginyl-beta-hydroxylase." Thesis, University of Oxford, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711703.
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Bon, Marie-Claude. "Aspects biochimiques du clonage de sequoias geants (sequoiadendron giganteum buchholz) jeunes et ages." Clermont-Ferrand 2, 1988. http://www.theses.fr/1988CLF21076.
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L'efficacite de la micropropagation du sequoia geant demeure conditionnee par l'etat de juvenilite des explants, sous la dependance de l'age physiologique. La synthese des analyses proteiques en tenant compte de l'influence des parametres physiologiques et genotypiques permet de proposer une proteine membranaire de 16000 daltons (j16) comme marqueur du degre de juvenilite ou par corollaire de maturite, renseignant notamment sur les potentialites organogenes de reactivite des explants en vue du clonage conforme
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Chen, Wan-tze, and 陳菀澤. "Synthesis of core-shell Raman markers." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/27758461621270957254.
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碩士國立中正大學
化學所
94
The common method for DNA detecting is using matrix surface to bind single-stranded DNA and to capture single-stranded complementary DNA. The combinatorial DNA microarray is one of this type of detection, but it costs a lot and is very time-consuming in manufacturing. Comparing colloid nanoparticle with the combinatorial DNA microarrays, we can see the colloid nanoparticle is cheaper in producing. Consequently, we adopt the method of the colloid nanoparticle instead of the method of the combinatorial DNA microarrays. Fluorescence dyes are commonly used as optical barcodes. However, while several fluorescence dyes are detected at same time, the peaks appear overlapped. In this research, we used surface-enhanced Raman scattering (SERS) spectra of dye molecules that absorb gold on nanoparticles as optical barcodes. We utilized the dye X-Rhodamine-5-(and-6) -isothiocyanate (XRITC) as the Raman marker and the aggregation agent of Au nanoparticle. Then, we capped a silica shell in the Au cluster surface to protect adsorbed dyes. Finally, we apply micoremulsion to produce one smooth and thick silica layer on the core-shell Au cluster, so that the silica surface is more effective for further functionization and Raman markers have the same size. We detect not only SERS spectra of bulk Raman markers, but also SERS spectra of single clusters that could be developed as biosensors.
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Rumble, Tony. "Synthetic equity and franked debt : capital markets savings cures /." 1998. http://www.library.unsw.edu.au/~thesis/adt-NUN/public/adt-NUN20010119.152830/index.html.
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KU, YOE-RAY, and 顧祐瑞. "Analysis of marker constituents and synthetic therapeutic substances adulterated in traditional Chinese medicines." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/92701146543540207397.
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博士中國醫藥學院
中國藥學研究所
88
ABSTRACT The adulteration by synthetic therapeutic substances in traditional Chinese medicines (TCM) has been reported on many occasions and has been a public health concern in Taiwan over the past years. The term "adulteration" refers to TCM tested and found to contain chemical substances not prescribed or labeled as part of the intended use. The adulteration by synthetic therapeutic substances in TCM was banned for the reasons of public safety by the health authorities in Taiwan. Four pharmacological categories of chemical drugs, xanthine bronchodilators: caffeine, diprophylline, proxyphylline, theobromine and theophylline; steroids: betamethasone, cortisone acetate, dexamethasone, hydrocortisone acetate, methylprednisolone, prednisolone, prednisone and triamcinolone; anorexics: clobenzorex, diethylpropion, fenfluramine, methamphetamine, phenylpropanolamine and phentermine and gastrointestinal drugs: cimetidine, homatropine, metoclopramide, pirenzepine, ranitidine and scopolamine butylbromide, adulterated in TCM were assayed by solid-phase extraction with high-performance liquid chromatography or high-performance capillary electrophoresis. A high-performance liquid chromatographic method in combination with C18 reversed phase SPE was also developed for the determination of caffeine in traditional Chinese medicinal prescriptions which contain Theae Folium. Six frequently used prescriptions were studied by above methods. These prescriptions include Shin-Yi-San, Chuan-Chyong-Char-Tyau-San, Tsang-Eel-San, San-Hwang-Shyr-Gau-Tang, Tzy-Shenn-Ming-Mu-Tang and Shiang-Chyong-San.
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Matias, Mariana Sofia Brigida. "Synthesis and integration of a nano-marker in security inks." Master's thesis, 2019. http://hdl.handle.net/10362/72304.
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Shih, Jhen-Ling, and 施貞伶. "The Synthetic Analysis and Prediction for the Association between Taiwan Stock Market and Asian Stock Markets." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/5t3ef7.
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碩士朝陽科技大學
財務金融系
105
With the advancement of information technology and financial innovation, the business models for traditional financial industry have been rapidly changed by the new emerge technologies. In recent years, the use of big data analysis with data mining has become one of the important techniques to accelerate the innovation of financial service since the Financial Supervisory Commission started promoting the development of financial technology and released the Development Strategy White Paper as a guidance for the development of FinTech industry in 2016. In this study, we used data mining techniques to explore the mutual influence among Asian stock markets. Both association rule and cluster analysis were applied to discover the interesting correlations or unrevealed linkage relationships between different markets. The experiment result of association rules showed that 12 out of 24 Asian market indexes tended to have a mutual linkage relationship with Taiwan Stock Exchange Weighted Index, and especially the Bombay Stock Exchange Limited and the Korea Composite Stock Price Index achieved higher linkage score than others. Through the cluster analysis, the results showed that all 24 Asian stock markets rose simultaneously in cluster A and cluster C, and the stock market changes for cluster A were higher than that of cluster C. The top 3 stock markets listed in the cluster A were Hang Seng Index (Hong Kong), Hang Seng China Enterprises Index and Shenzhen Stock Exchange Component Index. On the other hand, the cluster B represented the falling stock markets, and its top 3 markets included the Hang Seng Index (Hong Kong), Hang Seng China Enterprises Index and Nikkei 225. The synthesis result of using both association rule and cluster analysis suggested that the Hang Seng Index (Hong Kong) accounted for the greatest linkage relationship with the Taiwan stock market. Finally, the genetic programming method was applied to predict the stock market direction in Taiwan, and the experimental results showed that the Model 6 outperformed the other models, and its forecasting accuracy was more than 70%.
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Bing-Yi, Chen, and 陳秉毅. "An Empirical Study on the China, Taiwan, and Hong Kong Stock markets: A Synthetic Analysis of Technical Indicators." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/89377310080596176165.
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碩士嶺東科技大學
財務金融研究所
96
This study aims at the validity of using technical analysis on China, Taiwan, and Hong Kong stock markets. Sample includes day/monthly interrals, Up/Down market circulation, and cut for 4 stages according with declare point of China decisive open policies. This study uses KD, MA, RSI, Momentum, Channel Breakout, and MACD technical indicator, and build two kinds of transaction tactics, single and double technical indicator. The conclusion is as follows: The validity of using technical analysis is relatively apparent in the Shanghai B-share and the Shenzhen B-share; it is thereafter Shenzhen A-share, TWSE, Hang Seng, and Shanghai A-share index in order. The technical analysis result implys China doesn’t relatively have efficient nature on Taiwan and H.K. stock market, and China B-share doesn’t have efficient nature on the A -share market. The validity of using technical analysis is more apparent in the Bear Market period, than in the Bull Market period. In addition, the validity of during the 4 stages of China stock market, each stage shows that validity of technical analysis is decreasing, it confirms the China market is more and more efficient, especially B-share market. The validity of using single technical analysis on China, Taiwan, and Hong Kong stock markets depend on level order: Momentum, Channel Breakout, MACD, MA, KD and RSI. Using double technical indicator in the bear market period has better abnormal return. Besides, the validity of using double technical analysis on level order TWSE, Shanghai B-share, Shenzhen B-share, Shenzhen A-share, Shanghai A-share, Hang-seng Index. In addition, putting Momentum or Channel Breakout into the double indicator, the probability that abnormal return is higher than all single technical indicators is relatively high.
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Staveren, Dave Richard van [Verfasser]. "Robust transition metal markers for labelling of peptides via solid phase synthesis methods / presented by Dave Richard van Staveren." 2001. http://d-nb.info/962393665/34.
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Chun-YiWang and 王君儀. "The acetaldehyde exposure assessment of workers in using vinyl acetate to manufacture adhesives and synthetic resins plants and establishment of biological monitoring marker." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/6a95wy.
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碩士國立成功大學
環境醫學研究所
105
The objectives of present study are to assess the exposure profile for vinyl acetate using workers, explore the association between vinyl acetate and acetaldehyde exposure and adverse health effects and assess the availability of exhaled air as biological monitoring marker. The area, personal exposure and exhaled air levels of vinyl acetate and acetaldehyde were collected and analyzed for seventy workers recruited from three vinyl acetate using plants. Because vinyl acetate will react with water and then transform to acetaldehyde, higher levels of acetaldehyde were determined near the reactor and resulted in an increasing acetaldehyde exposure for the workers. After adjusting alcohol drinking and time activity pattern, the significantly correlated between the acetaldehyde level in exhaled breath and those in personal exposure air was found, it means that the exhaled air levels of acetaldehyde could be a good biological monitoring marker. We use exhaled acetaldehyde levels to calculate life-time average daily dose and assess the relationship betwwn long-term acetaldehyde exposure and healthy outcomes. After adjusting age, body mass index (BMI), sex, smoking and alcohol drinking, exposure index were significantly positively associated with EBV-VCA-IgA that exclude the five workers of outlier levels. The exposure index were significantly negatively associated with aspartate aminotransferase (GOT), blood urea nitrogen (BUN). After adjusting age, waist-to-hip ratio, taking hormone medicine and using adhesive, exposure index were significantly positively associated with follicle-stimulating hormone (FSH) and were significantly negatively associated with androstenedione (AD). It means that long-term exposure to acetaldehyde may occur the potential effect of nasopharyngeal carcinoma, and reduced the GOT activity and the reproductive hormones could be interfered. The results of health risk assessment of acetaldehyde exposure shows that hazard index (HI) for noncarcinogenic risk of area air in 15 area sampling points, personal air in 9 workers and exhaled breath in all workers were higher than 1. The carcinogenic risk of acetaldehyde exposure in one area sampling points were higher than acceptable risk (10-3).
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Ouellet, Marie. "Precursors and prices : structuring the Quebec synthetic drug market." Thèse, 2012. http://hdl.handle.net/1866/8959.
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Information recueillie sur les marchés des drogues de synthèse est beaucoup moins avancée que les études sur d'autres marchés de drogues illicites. La classification relativement récente des drogues de synthèse comme substances illicites, couplée avec ses caractéristiques distinctes qui empêchent son observation, a entravé le développement d’évaluations complètes et fiables des caractéristiques structurelles des marchés. Le but de cet article est de fournir un aperçu fiable sur la dynamique interne du marché des drogues synthétiques, en particulier sur ses caractéristiques structurelles et organisationnelles. En utilisant l'information obtenue à partir de 365 drogues de synthèse saisies par les policiers pendant un an, cette étude sera la fusion de deux techniques, soit la composition des drogues illicites et des analyses économiques, afin de tirer des évaluations fiables des caractéristiques structurelles du marché du Québec de drogues synthétiques. Les résultats concernant l'analyse de la composition des drogues indiquent que le marché des drogues synthétiques au Québec est probablement composé d'un nombre élevé de petites structures, ce qui indique un marché compétitif. L'analyse économique a également fourni des informations complémentaires sur le marché des drogues. Selon la région géographique les couts de la production et les relations entre trafiquant et consommateur influencent le prix des drogues. Les résultats de cette recherche mettent l'accent sur la nécessité de concevoir des politiques qui tient compte des différences régionales dans la production de drogue et reflète la nature compétitive de ce marché.Research gathered on synthetic drug markets trails behind studies on other illegal drug markets. Synthetic drug's relatively recent classification as an illicit substance, coupled with its distinct characteristics that insulate it from detection has hindered the development of reliable assessments of the markets structural features. The purpose of this study is to provide reliable insight into the inner dynamics of Quebec’s synthetic drug industry, focusing on its organizational features. Using information derived from 365 synthetic drugs seized by law enforcement over a one year period, this study will merge two techniques, drug composition and economic analyses, under a common framework to derive reliable and comprehensive assessments of the structure of Quebec's synthetic drug market. Drug composition analysis examines the drug’s chemical and physical profile to make inferences about the market structure while the economic analysis examines price determinants for the same market, providing further insight into its dynamics and distinctive features. Findings from the drug composition analysis indicate that the synthetic drug market in Quebec is likely to be composed of a high number of small structures, indicating a competitive market. The economic analysis provided complementary information, finding that both differential production costs and trafficker-consumer relations may influence price variations, depending on the region. This study concludes by emphasizing that drug composition analysis should be diligently pursued by both researchers and enforcement organizations alike to effectively target and enhance our understanding of the intricate processes that underlie the synthetic drug market.
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Wieler, Sven. "Market conditions within the chemical industry: an examination of the market potential of acrylonitrile butadiene rubber." Master's thesis, 2011. http://hdl.handle.net/10071/4225.
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No seu começo, a indústria da borracha começou por contar apenas com a borracha natural
para produzir bens com fins variados, desde produtos para o lar como produtos industriais. A
borracha sintética, inventada em 1909, veio substituir a borracha de origem natural em vários
campos de utilização. A aplicação deste tipo de borracha também está presente num vasto
largo de produtos, estando presente em auto-estradas assim como num consultório médico.
Um segmento da borracha sintética é representado pelo mercado acrylonitrile-butadiene
(NBR). A NBR é muitas vezes considerada o elemento laborioso da indústria de produção de
borracha com fim industrial e para a indústria automóvel.
Esta dissertação investiga a posição competitiva do portefólio de produtos de uma empresa
relativamente à atractividade do mercado quanto a um campo específico no mercado de NBR.
No curso desta análise, os diferentes segmentos de mercado estão definidos assim como a
envolvente externa, incluindo a estrutura dos segmentos definidos e fornecedores a competir
neste mercado, são analisados. Adicionalmente, as condições internas da empresa e o seu
portefólio de produtos também serão alvo de investigação. A conclusão gerada por esta
análise representa a base para a proposta de estratégia de mercado.In earlier days the rubber industry relied solely on natural rubber to produce goods with a widespread range from household to industrial products. Since synthetic rubber was innovated in 1909 is subsequently substituted natural rubber in many fields of application. Synthetic rubber products are used in widespread application areas ranging from the highway to the doctor’s office. One segment of synthetic rubber is represented by the acrylonitrile-butadiene (NBR) market. NBR is commonly considered the workhorse of the industrial and automotive rubber product industries. This dissertation investigates the competitive position of a firm’s product portfolio with regard to the overall market attractiveness of one special field in the NBR market. In the course of this analysis the different market segments are defined and the external environment, including the structure of the defined segments and suppliers competing in this market are examined. Further the situations of the firm’s internal conditions and its product portfolio are investigated. The conclusion derived from this analysis represent the basis upon a market strategy is proposed.
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(6863093), Li-Kai Lin. "Pollutant and Inflammation marker detection using low-cost and portable microfluidic platform, and flexible microelectronic platform." Thesis, 2019.
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Existing methods for pathogen/pollutant detection or wound infection monitoring employ high-cost instruments that could only be operated by trained personnel, and costly device-based detection requires a time-consuming field-to-lab process. This expensive process with multiple prerequisites prolongs the time that patients must wait for a diagnosis. Therefore, improved methods for point-of-care biosensing are necessary. In this study, we aimed to develop a direct, easy-to-use, portable, low cost, highly sensitive and selective sensor platform with the goal of pollutant detection and wound infection/cancer migration monitoring. This study has two main parts, including microfluidic, electrical, and optical sensing platforms. The first part, including chapters 2, 3, and 4, focuses on Bisphenol A (BPA) lateral flow assay (LFA) detection; the second part, including chapter 5 focuses on the electrical sensing platform fabrication for one of the markers of inflammation, matrix metalloproteinases-9 (MMP-9), monitoring/detection. In chapters 2, 3, and 4, we found that the few lateral flow assays (LFAs) established for detecting the endocrine-disrupting chemical BPA have employed citrate-stabilized gold nanoparticles (GNPs), which have inevitable limitations and instability issues. To address these limitations, in chapter 2, a more stable and more sensitive biosensor is developed by designing strategies for modifying the surfaces of GNPs with polyethylene glycol and then testing their effectiveness and sensitivity toward BPA in an LFA. In chapter 3, we describe the development of a new range-extended bisphenol A (BPA) detection method that uses a surface enhanced Raman scattering lateral flow assay (SERS-LFA) binary system. In chapter 4, we examine advanced bisphenol A (BPA) lateral flow assays (LFAs) that use multiple nanosystems. The assays include three nanosystems, namely, gold nanostars, gold nanocubes, and gold nanorods, which are rarely applied in LFAs, compared with general gold nanoparticles. The developed LFAs show different performances in the detection of BPA. In chapter 5, a stable electrical sensing platform is developed for MMP-9 detection.
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Lin, Yeh-Chun, and 林業鈞. "Part I. Carbon Nanoparticle-Enhanced Immunoelectrochemical Detection for Protein Tumor Marker with Cadmium Sulfide Biotracers ; Part II. Synthesis of Liposomes Using Double Emulsion Template and Syringe Filter." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/38395740385736139407.
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碩士國立清華大學
化學系
97
In the first part of thesis, we have presented a sensitive electrochemical immunoassay system for the detection of a protein tumor marker, carcinoembryonic antigen (CEA), that is based on a carbon nanoparticle (CNP)/poly(ethylene imine) (PEI)-modified screen-printed graphite electrode (CNP–PEI/SPGE) covered with anti-CEA antibodies. The signal amplification strategy–using CdS nanocrystals as biotracers and CNPs to enhance electron transfer–improves the sensitivity and detection limit for CEA, suggesting that this system holds promise for development into a point-of-care or disposable home-care self-diagnostic tool. This biosensor is based on a sandwich complex immunoassay, which we assembled from sequential layers of the anti-CEA antibody (�哸EA) on CNP–PEI/SPGE, the CEA sample, and the CdS nanocrystal quantum dots (QDs) sensitized with �哸EA (�哸EA–CdS QD). We used square wave anodic stripping voltammetry (SWASV) to amplify the signal current response obtained from the dissolved �哸EA–CdS QDs. The calibration curve for CEA concentration was linear in the range of 0.032–10 ng/mL; the detection limit (estimated as the mean of the blank sample plus three times the standard deviation obtained on the blank sample) was 32 pg/mL (equivalent to 160 fg in a 5 �尳 sample). This method is suitably precise and sensitive to function as a means of determining urinary CEA, which is a better marker than serum CEA for the early detection of urothelial carcinoma. In the second part of thesis, a simple-used and programmable injection device was developed, using syringe filter and glass device, to manufacture liposomes with high encapsulation efficiency based on double emulsion template. First of all, aqueous solutions and lipids in chloroform were injected into the glass device by infusion pumps respectively to form water-in-oil-in-water double emulsions. It was followed by the removal of chloroform by rotary evaporator for converting double emulsions to liposomes. At the end of the process, non-encapsulated fluorescent dye molecules were separated from liposomes by dialysis. The encapsulation efficiencies of liposomes are around 26%, and the expected size of liposomes could be achieved by syringe filter membranes with designated pore size. This device is workable with neither sonicator nor delicate microfluidic system, and is suitable for manufacture of liposomes as carriers of signal molecules or drugs with high encapsulation efficiency.
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Li, Yu. "Remotely Sensed Data Segmentation under a Spatial Statistics Framework." Thesis, 2010. http://hdl.handle.net/10012/4931.
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In remote sensing, segmentation is a procedure of partitioning the domain of a remotely sensed dataset into meaningful regions which correspond to different land use and land cover (LULC) classes or part of them. So far, the remotely sensed data segmentation is still one of the most challenging problems addressed by the remote sensing community, partly because of the availability of remotely sensed data from diverse sensors of various platforms with very high spatial resolution (VHSR). Thus, there is a strong motivation to propose a sophisticated data representation that can capture the significant amount of details presented in a VHSR dataset and to search for a more powerful scheme suitable for multiple remotely sensed data segmentations.
This thesis focuses on the development of a segmentation framework for multiple VHSR remotely sensed data. The emphases are on VHSR data model and segmentation strategy. Starting with the domain partition of a given remotely sensed dataset, a hierarchical data model characterizing the structures hidden in the dataset locally, regionally and globally is built by three random fields: Markova random field (MRF), strict stationary random field (RF) and label field. After defining prior probability distributions which should capture and characterize general and scene-specific knowledge about model parameters and the contextual structure of accurate segmentations, the Bayesian based segmentation framework, which can lead to algorithmic implementation for multiple remotely sensed data, is developed by integrating both the data model and the prior knowledge.
To verify the applicability and effectiveness of the proposed segmentation framework, the segmentation algorithms for different types of remotely sensed data are designed within the proposed segmentation framework. The first application relates to SAR intensity image processing, including segmentation and dark spot detection by marked point process. In the second application, the algorithms for LiDAR point cloud segmentation and building detection are developed. Finally, texture and colour texture segmentation problems are tackled within the segmentation framework.
All applications demonstrate that the proposed data model provides efficient representations for hierarchical structures hidden in remotely sensed data and the developed segmentation framework leads to successful data processing algorithms for multiple data and task such as segmentation and object detection.
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Lo, Yi-Hsuan, and 羅逸軒. "Synthesis and biological evaluation of nicotinamide/picolinamide derivatives as novel melanoma diagnostic probes and Tau protein imaging as a potential predictive marker in cancers treated with paclitaxel chemotherapy." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/n37xmg.
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Ehrich, Malte. "Essays on effects of policy interventions in the realm of food standards, trade, and the German labour market." Doctoral thesis, 2017. http://hdl.handle.net/11858/00-1735-0000-0023-3DFB-3.
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Amador, Gonçalo Alexandre Camões de Bastos. "Optimization of the synthesis and manufacturing process of platforms for 3D culture produced from blood plasma proteins." Master's thesis, 2021. http://hdl.handle.net/10773/33004.
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Metatissue® is a spin-off business on the making, dedicated to the development of innovative, chemically modified, human protein-based biomaterials for cell culture . Nowadays, mammalian cell culture is a fundamental aspect in most biomedical research and in the drug discovery/development process. The standard two-dimensional culturing format, extensively used for validating mechanisms of action is outdated, due to being unable to accurately mimic the natural in vivo microenvironment. Advances in biotechnology and materials science led to the development of numerous three-dimensional (3D) cell culture models, proven to simulate more accurately the natural tissue microenvironment, by mimicking the native extracellular matrix in its bio functionality and structural properties. Hydrogels composed from differently sourced materials are the leading platform in the market for cell culture and tissue engineering applications. However, it is yet to be found a perfect solution to be an alternative to current “gold standard” platforms. Metatissue’s human-derived platelet lysate product presents a xeno-free, customizable, versatile, and multifunctional solution, with tuneable mechanical properties, being easy-to-use and cost-effective. Legal framing is also considered, and an ISO 9001 certification is being implemented to guarantee the quality and consistency of the product. With a clear business strategy and value proposition, Metatissue® aims to be a leader in the 3D cell culture market.A Metatissue® é uma empresa spin-off em ascensão, dedicada ao desenvolvimento de biomateriais inovadores para cultura celular, à base de proteínas humanas, quimicamente modificadas. Atualmente, a cultura de células de mamífero é um aspeto fundamental na maioria da investigação biomédica e no processo de descoberta/desenvolvimento de fármacos. O formato padrão bidimensional de cultura, extensivamente utilizado para validar mecanismos de ação, está desatualizado, devido a ser incapaz de imitar precisamente o microambiente natural in vivo. Os avanços na biotecnologia e engenharia de materiais levaram ao desenvolvimento de inúmeros modelos tridimensionais (3D) de cultura de células, comprovados em simular melhor o microambiente dos tecidos naturais, ao imitar a matriz extracelular nativa na sua bio funcionalidade e propriedades estruturais. Hidrogéis compostos por materiais com diferentes origens são a plataforma que lidera o mercado em aplicações de cultura celular e engenharia de tecidos. Porém, ainda se está por descobrir uma solução perfeita para ser alternativa às plataformas padrão ideais atuais. O produto de lisado de plaquetas de origem humana da Metatissue® representa uma solução sem componentes de espécies estranhas, personalizável, versátil e multifuncional, com propriedades mecânicas adaptáveis, sendo fácil de usar e de favorável custo-benefício. O enquadramento legal é também considerado e um certificado ISO 9001 está a ser implementado, de forma a garantir a qualidade e consistência do produto. Com uma clara estratégia de negócio e proposta de valor, a Metatissue® pretende ser um líder no mercado da cultura de células 3D.
Mestrado em Biotecnologia
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Beranová, Kateřina. "Užívání Nových Syntetických Drog (NSD) mezi problémovými uživateli - distribuce NSD na otevřené drogové scéně ČR a jejich identifikace." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-349513.
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New synthetic drugs are a new phenomenon that is expanding in many countries. NSD mimic the effects of traditional drugs phenomenological, but retain the hallmark of legal substances. NSD legal status is due to the fact that theses new substances are controlled by the United Nations Single Convention on Narcotic Drugs of 1961 or the UN Convention on Psychotropic Substances, 1971. To the Czech Republic this trend came somewhat later than in neighboring countries, and especially in 2010, when sales NSD was mainly in shops. This sale was completed in April 2011 becouse of entering 33th NSD to the list of psychotropic and narcotic substances and moved mostly to the internet. NSD composition is often changing, due to disabling preparatory material, it follows that the risks associated with the use of NSD are unpredictable. The research objective of this study is to determine the acquisition and distribution of NSD between problem drug users and also to map the most widely used NSD among this population.The main purpose of the research is to bring knowledge (as it's called, how it look, what it contains, where and from whom it receives, how much it costs). The survey was made up of semi-structures interviews (qualitative part) and structured questionnaires (quantitative part). Respondents were selected...
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Pal, Arnab. "Design, synthesis, and screening of a library of peptidyl bis-boroxoles as low molecular weight receptors for complex oligosaccharides in neutral water identification of a selective receptor for the tumour marker TF-antigen /." Master's thesis, 2009. http://hdl.handle.net/10048/808.
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Thesis (M. Sc.)--University of Alberta, 2009.Title from pdf file main screen (viewed on Jan. 11, 2010). "A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Master of Science, Department of Chemistry, University of Alberta." Includes bibliographical references.