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1

Fossum, John A. Labor relations: Development, structure, process. 8th ed. Boston: McGraw-Hill/Irwin, 2002.

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K, Kazanjian Robert, ed. Strategy implementation: Structure, systems, and process. 2nd ed. St. Paul: West Pub. Co., 1986.

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Kumar, V. Anand. Business process outsourcing: Oh! BPO--structure and chaos, fun and agony. New Delhi: Sage Publications, 2008.

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4

Practices, LLC Best. Bolstering product portfolios: Resources, structure and process for effective in-licensing organizations. Chapel Hill, NC: Best Practices, LLC, 2003.

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Bashin, Yuriy, Gennadiy Grinev, and Yuliya Dremova. Economics of the information society. ru: INFRA-M Academic Publishing LLC., 2020. http://dx.doi.org/10.12737/1039916.

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The textbook presents modern ideas about the development and formation of the economy of the information society. Scientific concepts of transformation of the modern post-industrial society into an information society based on information and communication technologies and knowledge are highlighted. The basic concepts of technological processes of the information society, as well as definitions and dynamics of development of information resources, products and services in the economy of the information society, and a number of other topical issues are presented. The structure of the manual helps to identify the main aspects of the studied socio-economic processes, organize and specify the educational process. Questions for self-control and tasks are offered to activate the assimilation of the material. Meets the requirements of the Federal state educational standards of higher education of the latest generation. It is intended for students of higher educational institutions studying in the field of training 38.03.05 "Business Informatics".
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6

Kovalenko, Vladimir. Design of information systems. ru: INFRA-M Academic Publishing LLC., 2020. http://dx.doi.org/10.12737/987869.

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The tutorial discusses the design features of information systems (is) involved in the implementation of CALS technologies: MRP/MRPII/ERP systems, e-Commerce systems (B2B), supply chain management (SCM), customer relationship management (CRM), and decision support systems (OLAP). The issues of choosing the design technology, software tools for project development, building functional and information models in the environment of Business Studio, MS Visio, Elma, AllFusion Modeling Suite and Oracle Designer 10g, as well as the development of technical and operational documentation are highlighted. The characteristics of CASE technologies and their implementation in the Oracle Designer 10g environment are considered. A comparative analysis of the standards of the organization of the life cycle of creating and using IP, practical recommendations for the development of standard profiles, examples of the development of an IP project based on a cascading model of the life cycle, including using a process approach in the management and automation of processes. The models of the client — server architecture and the structure of cloud computing are considered. Modern approaches to the selection of ready-made is and their implementation in automated enterprises are studied in detail. Meets the requirements of the Federal state educational standards of higher education of the latest generation. It is intended for students (bachelors and specialists) and masters of higher educational institutions studying in the direction of "Applied Informatics". It is also recommended for teachers and specialists working in the field of information technology.
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Cevelev, Aleksandr. Strategic development of railway transport logistics. ru: INFRA-M Academic Publishing LLC., 2021. http://dx.doi.org/10.12737/1194747.

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The monograph is devoted to the methodology of material and technical support of railway transport. According to the types of activities, the nature of the material and technical resources used, technologies, means and management systems, Russian railways belong to the category of high-tech industries that must have high quality and technical level, reliability and technological efficiency in operation. For this reason, the logistics system itself, both in structure and in the algorithm of the functions performed as a whole, needs a serious improvement in the quality of its work. The economic situation in Russia requires a revision of the principles and mechanisms of management based on the corporate model of supply chain management, focused on logistics knowledge. In the difficult economic conditions of the current decade, it is necessary to improve the quality of the supply organization of enterprises and structural divisions of railway transport, directly related to the implementation of the process approach, the advantage of which is a more detailed regulation of management actions and their mutual coordination. In order to increase the efficiency of its activities and develop the management system, Russian Railways is developing a lean production system aimed at further expanding the implementation of the principles of customer orientation, ideology and corporate culture. At the present time, the solution of many issues is impossible without a cybernetic approach to the formulation of problems of material and technical support and logistics analysis of information technologies, to the implementation of the developed algorithms and models of development strategies and concepts for improving the business processes of the production system. The management strategy, or the general plan for the implementation of activities for the management of material resources, is based on a fundamental assessment of the alignment and correlation of forces and factors operating in the economic and political field, taking into account the impact on the specific form of the management strategy. The materials will be useful to the heads and specialists of the directorates of the MTO, CDZs and can be used in the scientific research of bachelors, masters and postgraduates interested in the economics of railway transport and supply logistics.
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8

Ethnic entrepreneurship: Structure and process. Amsterdam: JAI, 2004.

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9

Organizational Strategy, Structure, and Process (Stanford Business Classics). Stanford Business Books, 2003.

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10

Snow, Charles C. Organizational Strategy, Structure, and Process (Stanford Business Books). Stanford University Press, 2003.

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11

Designing organizations: Strategy, structure, and process at the business unit and enterprise levels. Jossey-Bass, 2014.

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12

Galbraith, Jay R. Designing Organizations: Strategy, Structure, and Process at the Business Unit and Enterprise Levels. Wiley & Sons, Incorporated, John, 2014.

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13

Galbraith, Jay R. Designing Organizations: Strategy, Structure, and Process at the Business Unit and Enterprise Levels. Wiley & Sons, Incorporated, John, 2014.

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14

Transforming business with program management: Integrating strategy, people, process, technology, structure, and measurement. 2015.

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15

Galbraith, Jay R. Designing the Customer-Centric Organization: A Guide to Strategy, Structure, and Process. Wiley & Sons, Incorporated, John, 2011.

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16

Galbraith, Jay R. Designing the Customer-Centric Organization: A Guide to Strategy, Structure, and Process. Wiley & Sons, Incorporated, John, 2007.

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17

(Editor), Curt Stiles, and Craig S. Galbraith (Editor), eds. Ethnic Entrepreneurship, Volume 4: Structure and Process (International Research in the Business Disciplines) (International Research in the Business Disciplines). JAI Press, 2003.

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18

Lindenmayer, David. Forest Pattern and Ecological Process. CSIRO Publishing, 2009. http://dx.doi.org/10.1071/9780643098305.

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Forest Pattern and Ecological Process is a major synthesis of 25 years of intensive research about the montane ash forests of Victoria, which support the world's tallest flowering plants and several of Australia's most high profile threatened and/or endangered species. It draws together major insights based on over 170 published scientific papers and books, offering a previously unrecognised set of perspectives of how forests function. The book combines key strands of research on wildfires, biodiversity conservation, logging, conservation management, climate change and basic forest ecology and management. It is divided into seven sections: introduction and background; forest cover and the composition of the forest; the structure of the forest; animal occurrence; disturbance regimes; forest management; and overview and future directions. Illustrated with more than 200 photographs and line drawings, Forest Pattern and Ecological Process is an essential reference for forest researchers, resource managers, conservation and wildlife biologists, ornithologists and mammalogists, policy makers, as well as general readers with interests in wildlife and forests. 2010 Whitley Certificate of Commendation for Zoological Text.
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19

Ramsay, James David. CAUSAL FACTORS OF NURSING FACILITY QUALITY: AN EMPIRICAL TEST OF THE STRUCTURE, PROCESS AND OUTCOME QUALITY PARADIGM. 1994.

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20

Designing the Customer-Centric Organization: A Guide to Strategy, Structure, and Process (Jossey Bass Business and Management Series). Jossey-Bass, 2005.

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21

1954-, Biersack Robert, Herrnson Paul S. 1958-, and Wilcox Clyde 1953-, eds. Risky business?: PAC decisionmaking in congressional elections. Armonk, NY: M.E. Sharpe, 1994.

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22

Biersack, Robert, and Paul S. Herrnson. Risky Business?: Pac Decisionmaking in Congressional Elections (American Political Institutions and Public Policy). M.E. Sharpe, 1994.

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23

Biersack, Robert, and Paul S. Herrnson. Risky Business?: Pac Decisionmaking in Congressional Elections (American Political Institutions and Public Policy). M.E. Sharpe, 1994.

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24

Cox, Howard, and Daniel Raff. Business Performance 1975–2004. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780199574797.003.0003.

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After the Waldock Report, OUP began a process of gradual modernization that resulted in changes to its systems of business administration and corporate structure. Manufacturing and in-house printing became less profitable and were eventually discontinued, and emphasis shifted to product marketing, international business, and corporate management. The Press maintained throughout this change its traditional learned values in academic and trade publishing and the Delegates continued to play a significant role in decision-making. By the 1990s OUP had reinvented itself as a modern publishing enterprise and was able to exploit new opportunities in digital publishing and the global book trade. The chapter considers in detail the process of modernization through an analysis of business structure, annual surpluses, and book sales, and the contribution of key individuals, while placing OUP in the context of the wider UK and international publishing world.
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25

Greaves, Ian, and Paul Hunt. Post-Incident Recovery and Business Continuity. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199238088.003.0013.

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Chapter 13 covers information on the recovery process, community recovery committees, structure and function of the recovery coordinating group, agency roles, handover from response to recovery, identifying lessons from a major incident, business continuity, humanitarian consequences, resistance and resilience, foreign nationals, memorials and commemorations, shelter, return, investigations and enquiries, and victim identification
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26

Romanowski, Robert, ed. Sustainable development: Innovations in business. Wydawnictwo Uniwersytetu Ekonomicznego w Poznaniu, 2021. http://dx.doi.org/10.18559/978-83-8211-084-5.

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Innovation and sustainable development have become buzzwords in the 21st century with the idea of creative destruction launched by Joseph Alois Schumpeter being the base for evolutionary economics. However, new institutional economics helps to understand the necessity of support provided to entrepreneurs and innovators by science and administration to reduce the risk of launching the said innovations. This e-book is devoted to selected types of innovation. Every type of innovation is described with the use of theoretical background and is enriched by adequate case study. Traditional division into four types of innovation, proposed by J.A. Schumpeter (1934), containing product, process, organizational and marketing innovations, was widely accepted, including European Union institutions (OECD/Eurostat, 2008). The concept of innovation has long been dominated by a technical approach to the innovation process, despite the economic arguments exposed by one of the precursors of the theory of innovation and, at the same time, the school of evolutionary economics—Joseph Alois Schumpeter. Frequently, in the context of innovation, it is indicated that organizational and marketing aspects play a part in the successful introduction of innovation onto the market. The structure of the book is based on the typology proposed by Keeley, Walters, Pikkel and Quinn (2013), which focuses on the economic character of innovations. Ten types of innovation are directly related to Schumpeter’s and Oslo Manual classification. A new set of innovations emphasize the economic side of innovation process. The technical novelties are to support new configuration, offering or customers’ experience. This new approach is based on presumptions coming from design thinking idea, leading to user—driven innovation and on cooperation with institutions and entities supporting innovation process. The chapters are devoted to every type of innovation, grouped into three major parts: innovations based on configuration, offering and experience. In the book, configuration includes types of innovations focused on innermost workings of an enterprise and its business system. Offering part contains the types of innovations, that are focused on an enterprise’s core product (good or service), or a collection of its products. The last part, dedicated to innovations based on experience, is focused on more customer-facing elements of an enterprise and its business system.
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27

Li, Jie Jack. Top Drugs. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780199362585.001.0001.

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Drugs like Lipitor, Plavix, Taxol, and Zoloft are integral in today's medicinal world. These widely used products save lives and improve the quality of lives, playing a crucial role in everything from cholesterol management to cancer treatment. These advances in medicine were brought into existence after nuanced process of creation, featuring a wide range of chemical and pharmacological experimentation and discovery. Top Drugs: Their History, Pharmacology, and Synthesis provides an in-depth study on ten prominent drugs, outlining the chemistry behind each one's creation. Jie Jack Li, a medicinal chemist and an expert on drug discovery, offers a thorough analysis of the landscape of current drug development. The comprehensive text is divided by health issues, including cardiovascular, cancer, metabolic diseases, and infectious diseases. Each section features individual chapters on significant drugs, outlining the chemistry and history of the drug's discovery. Li begins each chapter with the product's history, providing necessary context. Li then proceeds to describe the mechanism of action, structure-activity relationship (SAR), bioavailability, metabolism, toxicology, the discovery route, and the process route. Top Drugs: Their History, Pharmacology, and Synthesis will acclimate students, scientists, and interested laypersons to the world of chemistry and drug discovery.
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28

Rao, Koneru Ramakrishna. Satya and Ahimsa. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199477548.003.0003.

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The third chapter discusses truth (satya) and non-violence (ahimsa) as the basic principles encompassing the entire spectrum of Gandhi’s thought. This chapter deals primarily with the philosophical foundations of Gandhian thought and practices. In Gandhi’s ontology, reality comprises two aspects—the transcendent and the immanent, the ideal and the actual. The dual aspects of reality often appear in the human condition as polarized. The perceived bipolarity sets up a dialectical process and results in a sequence of attempts to find practical synthesis of the ideal and the actual. This chapter is an attempt to address the theoretical conundrums surfacing in Gandhi’s work and sketch a plausible framework for a philosophical structure in order to understand Gandhi’s ideas and practices in the chapters that follow.
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29

Nicholls, Simon, Michael Pushkin, and Vladimir Ashkenazy. The Writings of Skryabin. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190863661.003.0002.

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An introduction by Boris de Schloezer gives the genesis of the final text in the section, the Preliminary Action, and explains its relation to Skryabin’s projected life-work, the Mystery. Section I: an effusion of Orthodox religious feeling from teenage years. Sections II-VII: Around 1900, an expression of rejection of God in the face of disillusion is followed by the text of the choral finale of the First Symphony, declaring faith in the power of art. An unfinished opera libretto, symbolic in narrative, expressing belief in Art’s power to seduce and persuade. Three notebooks develop a world view in which the world is the result of the self’s creative activity. The creation of art and of the universe are identical. There is a higher self, identical with divinity. Forgetfulness of individuality leads to freedom and universal consciousness. Section VIII: The literary poem written during the composition of the symphonic Poem of Ecstasy summarises the scenario developed in the notebooks. Life starts with the desire to create, delight in creative play meets opposition, the creative goal is achieved and disappointment sets in. The process is repeated until it is realized that the struggle is itself joyful and self-affirmation is achieved. Section IX: The text of the Preliminary Action is symbolic in structure. Primal Male and Female Principles emerge; the Female is identified with Death. Life arises from the union of energies. Struggle and bloodshed follow. The conclusion is an impulse towards unification, the synthesis of experience and dematerialisation. Both the complete first draft and the incomplete revision are included.
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30

Simon, Gleeson, and Guynn Randall. Part II The US Resolution Regime, 5 Fundamentals of Resolution Authority. Oxford University Press, 2016. http://dx.doi.org/10.1093/law/9780199698011.003.0005.

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This chapter looks at the history and fundamental elements of resolution authority as it has been developed and used in the United States. The goal of resolution authority in the United States has been to deal with failed banks and other financial institutions in a manner that stems runs, avoids contagion and preserves critical operations, the same goal as deposit guarantee schemes. First introduced in the United States in 1933 as part of the deposit insurance programme for banks, resolution authority was originally little more than the method by which the Federal Deposit Insurance Corporation honoured its obligations to insured depositors before evolving to its current state. Resolution authority, as conceived in the United States, has two principal components—the core resolution powers and the claims process. The core resolution powers consist of the authority to quickly separate the assets and viable parts of a failed bank's business (the good bank) from its capital structure liabilities (the bad bank), so that its critical operations are preserved and runs and contagion are avoided. It is virtually always completed in the United States over a weekend commonly known as resolution weekend. The claims process involves determining the validity and amount of the claims of individual holders of capital structure liabilities in accordance with ordinary principles of due process and distributing the residual value of the good bank to such holders in satisfaction of their claims. The claims process typically takes at least six to nine months to be completed in order to comply with ordinary principles of due process for potential claimants.
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31

Terpstra, Taco. Trade in the Ancient Mediterranean. Princeton University Press, 2019. http://dx.doi.org/10.23943/princeton/9780691172088.001.0001.

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From around 700 BCE until the first centuries CE, the Mediterranean enjoyed steady economic growth through trade, reaching a level not to be regained until the early modern era. This process of growth coincided with a process of state formation, culminating in the largest state the ancient Mediterranean would ever know, the Roman Empire. Subsequent economic decline coincided with state disintegration. How are the two processes related? This book investigates how the organizational structure of trade benefited from state institutions. Although enforcement typically depended on private actors, traders could utilize a public infrastructure, which included not only courts and legal frameworks but also socially cohesive ideologies. The book details how business practices emerged that were based on private order yet took advantage of public institutions. Focusing on the activity of both private and public economic actors, the book illuminates the complex relationship between economic development and state structures in the ancient Mediterranean.
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32

Martin, Alison J. Five Years as a “Hired Gun”. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780190457938.003.0011.

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This chapter describes the for-profit evaluation consulting setting, including organizational structure, position responsibilities, and funding and project types. Generation of new business is the lifeblood of for-profit consulting firms, and the chapter overviews the business development process, including individual staff members’ responsibilities. Essential skills for working in this setting also are discussed. This chapter concludes with some of the benefits and challenges for a community psychologist working in this setting. Finally, the appendix contains a list of questions to ask when pursuing employment in a for-profit evaluation consulting setting.
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33

Simon, Gleeson. Part VI Bank Group Supervision, 27 Pillar 3—Disclosure Requirements. Oxford University Press, 2018. http://dx.doi.org/10.1093/law/9780198793410.003.0027.

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The Basel pillar 3 regime constitutes a disclosure regime for regulated banks. The aim is to provide sufficient transparency for investors to ensure that the price which banks pay to raise capital in the market reflects the level of risk undertaken by the bank. The pillar 3 regime was restructured in 2015, and is in the process of being further restructured. This chapter discusses the March 2017 standards which were broadly brought into force as from 2017. The most important change introduced by the 2017 standards is the formalisation of the disclosure templates. Regulators have struggled with banks over pillar 3 disclosures for many years — in effect, each bank sought to present information in a way which is most relevant to oits particular business and structure, whereas regulators seek to achieve comparability across banks with different businesses and structures. This process has resulted in a tightening of disclosure standards applicable to pillar three disclosures, to the extent that the regulators now provide detailed disclosure templates for each subdivision of required disclosure.
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34

Chong, Wu-Ling. Chinese Indonesians in Post-Suharto Indonesia. Hong Kong University Press, 2018. http://dx.doi.org/10.5790/hongkong/9789888455997.001.0001.

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This book examines the complex situation of ethnic Chinese Indonesians in post-Suharto Indonesia, focusing on Chinese in two of the largest Indonesian cities, Medan and Surabaya. The fall of Suharto in May 1998 led to the opening up of a democratic and liberal space to include a diversity of political actors and ideals in the political process. However, due to the absence of an effective, genuinely reformist party or political coalition, predatory politico-business interests nurtured under the New Order managed to capture the new political and economic regimes. As a result, corruption and internal mismanagement continue to plague the bureaucracy in the country. The indigenous Indonesian population generally still perceives the Chinese minority as an alien minority who are wealthy, selfish, insular and opportunistic; this is partially due to the role some Chinese have played in perpetuating corrupt business practices. As targets of extortion and corruption by bureaucratic officials and youth/crime organisations, the Chinese are neither merely passive bystanders of the democratisation process in Indonesia nor powerless victims of corrupt practices. By focusing on the important interconnected aspects of the role Chinese play in post-Suharto Indonesia, via business, politics and civil society, this book argues, through a combination of Anthony Giddens’s structure-agency theory as well as Pierre Bourdieu’s notion of habitus and field, that although the Chinese are constrained by various conditions, they also have played an active role in shaping these conditions.
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35

Allen, Glenn Seven. The Singer Acts, The Actor Sings. Bloomsbury Publishing Plc, 2019. http://dx.doi.org/10.5040/9781350043091.

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The Singer Acts, The Actor Sings is a practical workbook for singers and actors in all disciplines, from musical theater through classical repertory to popular performance styles. The book addresses the needs of students and professionals alike, helping them face the challenges of musical performance undaunted and achieve the exhilarating feeling of living through song. Structured in three sections, this workbook first examines song structure, pitch, and style of accompaniment, enabling performers to live moment to moment within a piece of music. The subsequent sections provide clear explanations about what singing as a character really entails and how it works physiologically and artistically before taking the performer through the process of leaving preparation behind and getting down to the business of storytelling. Including online video exercises and demonstrations, The Singer Acts, The Actor Sings is an essential resource for all actors and singers. It will instill in them the competence and confidence to communicate through musical language and tell powerful stories through song.
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36

Clarke, Thomas, Justin O’Brien, and Charles R. T. O’Kelley, eds. The Oxford Handbook of the Corporation. Oxford University Press, 2019. http://dx.doi.org/10.1093/oxfordhb/9780198737063.001.0001.

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The Oxford Handbook of the Corporation assesses the contemporary relevance, purpose, and performance of the corporation. The corporation is one of the most significant, if contested, innovations in human history, and the direction and effectiveness of corporate law, corporate governance, and corporate performance are being challenged as never before. Continuously evolving, the corporation, as the primary instrument for wealth generation in contemporary economies, demands frequent assessment and reinterpretation. The focus of this work is the transformative impact of innovation and change on corporate structure, purpose, and operation. Corporate innovation is at the heart of the value-creation process in increasingly internationalized and competitive market economies, and corporations today are embedded in a world of complex global supply chains and rising state and state-directed capitalism. In questioning the fundamental purpose and performance of the corporation, this Handbook continues a tradition commenced by Berle and Means, and contributed to by generations of business scholars. What is the corporation and what is it becoming? How do we define its form and purpose and how are these changing? To whom is the corporation responsible, and who should judge the ultimate performance of corporations? By investigating the origins, development, strategies, and theories of corporations, this volume addresses such questions to provide a richer theoretical account of the topic.
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37

Weller, Patrick, Dennis Grube, and R. A. W. Rhodes. Comparing Cabinets. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780198844945.001.0001.

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Why is cabinet government so resilient? Despite many obituaries, why does it continue to be the vehicle for governing across most parliamentary systems? This book answers these questions by examining the structure and performance of cabinet government in five democracies: the United Kingdom, Denmark, the Netherlands, Switzerland, and Australia. The book is organized around the dilemmas that cabinet governments must solve: how to develop the formal rules and practices that can bring predictability to the daily business and allow consistent decision making; how to balance good policy with good politics; how to ensure cohesion between the factions and parties that constitute the cabinet while allowing levels of self-interest to be advanced; how leaders can balance persuasion and command; and how to maintain support through accountability at the same time as being able to make unpopular decisions. All these dilemmas are continuing challenges to cabinet government, never solvable, and constantly reappearing in different forms. We ask how traditions, beliefs, and practices shape the answers. The different practices between the democracies examined show there can be no single definition of cabinet government. This comparative approach provides analysis and insights into the process of cabinet government that cannot be achieved in the study of any single political system. We better understand the pressures on each system by appreciating the options that are elsewhere accepted as common beliefs.
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38

Coyne, Christopher J., and Peter Boettke, eds. The Oxford Handbook of Austrian Economics. Oxford University Press, 2015. http://dx.doi.org/10.1093/oxfordhb/9780199811762.001.0001.

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The Oxford Handbook of Austrian Economics provides an overview of the main methodological, analytical, and practical implications of the Austrian school of economics. This intellectual tradition in economics and political economy has a long history that dates back to Carl Menger in the late nineteenth century. The various contributions discussed in this book all reflect this "tension" of an orthodox argumentative structure (rational choice and invisible hand) to address heterodox problem situations (uncertainty, differential knowledge, ceaseless change).The Austrian economists, from the founders to today, seek to derive the invisible-hand theorem from the rational-choice postulate via institutional analysis in a persistent and consistent manner. The Handbook, which consists of nine parts, and 34 chapters, covers a variety of topics including: methodology, microeconomics (market process theory and spontaneous order), macroeconomics (capital theory and Austrian business cycle theory, and free banking), institutions and organizational theory, political economy, development and social change, and the 2008 financial crisis. The goals of the volume are twofold. First, to introduce readers to some of the main theories and insights of the Austrian school. Second, to demonstrate how Austrian economics provides a set of tools for making original and novel scholarly contributions to the broader economics discipline. By providing insight into the central Austrian theories, the volume will be valuable to those who are unfamiliar with Austrian economics. At the same time, it will be appealing to those already familiar with Austrian economics, given its emphasis on Austrian economics as a live and progressive research program in the social sciences.
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39

Skiba, Grzegorz. Fizjologiczne, żywieniowe i genetyczne uwarunkowania właściwości kości rosnących świń. The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 2020. http://dx.doi.org/10.22358/mono_gs_2020.

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Bones are multifunctional passive organs of movement that supports soft tissue and directly attached muscles. They also protect internal organs and are a reserve of calcium, phosphorus and magnesium. Each bone is covered with periosteum, and the adjacent bone surfaces are covered by articular cartilage. Histologically, the bone is an organ composed of many different tissues. The main component is bone tissue (cortical and spongy) composed of a set of bone cells and intercellular substance (mineral and organic), it also contains fat, hematopoietic (bone marrow) and cartilaginous tissue. Bones are a tissue that even in adult life retains the ability to change shape and structure depending on changes in their mechanical and hormonal environment, as well as self-renewal and repair capabilities. This process is called bone turnover. The basic processes of bone turnover are: • bone modeling (incessantly changes in bone shape during individual growth) following resorption and tissue formation at various locations (e.g. bone marrow formation) to increase mass and skeletal morphology. This process occurs in the bones of growing individuals and stops after reaching puberty • bone remodeling (processes involve in maintaining bone tissue by resorbing and replacing old bone tissue with new tissue in the same place, e.g. repairing micro fractures). It is a process involving the removal and internal remodeling of existing bone and is responsible for maintaining tissue mass and architecture of mature bones. Bone turnover is regulated by two types of transformation: • osteoclastogenesis, i.e. formation of cells responsible for bone resorption • osteoblastogenesis, i.e. formation of cells responsible for bone formation (bone matrix synthesis and mineralization) Bone maturity can be defined as the completion of basic structural development and mineralization leading to maximum mass and optimal mechanical strength. The highest rate of increase in pig bone mass is observed in the first twelve weeks after birth. This period of growth is considered crucial for optimizing the growth of the skeleton of pigs, because the degree of bone mineralization in later life stages (adulthood) depends largely on the amount of bone minerals accumulated in the early stages of their growth. The development of the technique allows to determine the condition of the skeletal system (or individual bones) in living animals by methods used in human medicine, or after their slaughter. For in vivo determination of bone properties, Abstract 10 double energy X-ray absorptiometry or computed tomography scanning techniques are used. Both methods allow the quantification of mineral content and bone mineral density. The most important property from a practical point of view is the bone’s bending strength, which is directly determined by the maximum bending force. The most important factors affecting bone strength are: • age (growth period), • gender and the associated hormonal balance, • genotype and modification of genes responsible for bone growth • chemical composition of the body (protein and fat content, and the proportion between these components), • physical activity and related bone load, • nutritional factors: – protein intake influencing synthesis of organic matrix of bone, – content of minerals in the feed (CA, P, Zn, Ca/P, Mg, Mn, Na, Cl, K, Cu ratio) influencing synthesis of the inorganic matrix of bone, – mineral/protein ratio in the diet (Ca/protein, P/protein, Zn/protein) – feed energy concentration, – energy source (content of saturated fatty acids - SFA, content of polyun saturated fatty acids - PUFA, in particular ALA, EPA, DPA, DHA), – feed additives, in particular: enzymes (e.g. phytase releasing of minerals bounded in phytin complexes), probiotics and prebiotics (e.g. inulin improving the function of the digestive tract by increasing absorption of nutrients), – vitamin content that regulate metabolism and biochemical changes occurring in bone tissue (e.g. vitamin D3, B6, C and K). This study was based on the results of research experiments from available literature, and studies on growing pigs carried out at the Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences. The tests were performed in total on 300 pigs of Duroc, Pietrain, Puławska breeds, line 990 and hybrids (Great White × Duroc, Great White × Landrace), PIC pigs, slaughtered at different body weight during the growth period from 15 to 130 kg. Bones for biomechanical tests were collected after slaughter from each pig. Their length, mass and volume were determined. Based on these measurements, the specific weight (density, g/cm3) was calculated. Then each bone was cut in the middle of the shaft and the outer and inner diameters were measured both horizontally and vertically. Based on these measurements, the following indicators were calculated: • cortical thickness, • cortical surface, • cortical index. Abstract 11 Bone strength was tested by a three-point bending test. The obtained data enabled the determination of: • bending force (the magnitude of the maximum force at which disintegration and disruption of bone structure occurs), • strength (the amount of maximum force needed to break/crack of bone), • stiffness (quotient of the force acting on the bone and the amount of displacement occurring under the influence of this force). Investigation of changes in physical and biomechanical features of bones during growth was performed on pigs of the synthetic 990 line growing from 15 to 130 kg body weight. The animals were slaughtered successively at a body weight of 15, 30, 40, 50, 70, 90, 110 and 130 kg. After slaughter, the following bones were separated from the right half-carcass: humerus, 3rd and 4th metatarsal bone, femur, tibia and fibula as well as 3rd and 4th metatarsal bone. The features of bones were determined using methods described in the methodology. Describing bone growth with the Gompertz equation, it was found that the earliest slowdown of bone growth curve was observed for metacarpal and metatarsal bones. This means that these bones matured the most quickly. The established data also indicate that the rib is the slowest maturing bone. The femur, humerus, tibia and fibula were between the values of these features for the metatarsal, metacarpal and rib bones. The rate of increase in bone mass and length differed significantly between the examined bones, but in all cases it was lower (coefficient b <1) than the growth rate of the whole body of the animal. The fastest growth rate was estimated for the rib mass (coefficient b = 0.93). Among the long bones, the humerus (coefficient b = 0.81) was characterized by the fastest rate of weight gain, however femur the smallest (coefficient b = 0.71). The lowest rate of bone mass increase was observed in the foot bones, with the metacarpal bones having a slightly higher value of coefficient b than the metatarsal bones (0.67 vs 0.62). The third bone had a lower growth rate than the fourth bone, regardless of whether they were metatarsal or metacarpal. The value of the bending force increased as the animals grew. Regardless of the growth point tested, the highest values were observed for the humerus, tibia and femur, smaller for the metatarsal and metacarpal bone, and the lowest for the fibula and rib. The rate of change in the value of this indicator increased at a similar rate as the body weight changes of the animals in the case of the fibula and the fourth metacarpal bone (b value = 0.98), and more slowly in the case of the metatarsal bone, the third metacarpal bone, and the tibia bone (values of the b ratio 0.81–0.85), and the slowest femur, humerus and rib (value of b = 0.60–0.66). Bone stiffness increased as animals grew. Regardless of the growth point tested, the highest values were observed for the humerus, tibia and femur, smaller for the metatarsal and metacarpal bone, and the lowest for the fibula and rib. Abstract 12 The rate of change in the value of this indicator changed at a faster rate than the increase in weight of pigs in the case of metacarpal and metatarsal bones (coefficient b = 1.01–1.22), slightly slower in the case of fibula (coefficient b = 0.92), definitely slower in the case of the tibia (b = 0.73), ribs (b = 0.66), femur (b = 0.59) and humerus (b = 0.50). Bone strength increased as animals grew. Regardless of the growth point tested, bone strength was as follows femur > tibia > humerus > 4 metacarpal> 3 metacarpal> 3 metatarsal > 4 metatarsal > rib> fibula. The rate of increase in strength of all examined bones was greater than the rate of weight gain of pigs (value of the coefficient b = 2.04–3.26). As the animals grew, the bone density increased. However, the growth rate of this indicator for the majority of bones was slower than the rate of weight gain (the value of the coefficient b ranged from 0.37 – humerus to 0.84 – fibula). The exception was the rib, whose density increased at a similar pace increasing the body weight of animals (value of the coefficient b = 0.97). The study on the influence of the breed and the feeding intensity on bone characteristics (physical and biomechanical) was performed on pigs of the breeds Duroc, Pietrain, and synthetic 990 during a growth period of 15 to 70 kg body weight. Animals were fed ad libitum or dosed system. After slaughter at a body weight of 70 kg, three bones were taken from the right half-carcass: femur, three metatarsal, and three metacarpal and subjected to the determinations described in the methodology. The weight of bones of animals fed aa libitum was significantly lower than in pigs fed restrictively All bones of Duroc breed were significantly heavier and longer than Pietrain and 990 pig bones. The average values of bending force for the examined bones took the following order: III metatarsal bone (63.5 kg) <III metacarpal bone (77.9 kg) <femur (271.5 kg). The feeding system and breed of pigs had no significant effect on the value of this indicator. The average values of the bones strength took the following order: III metatarsal bone (92.6 kg) <III metacarpal (107.2 kg) <femur (353.1 kg). Feeding intensity and breed of animals had no significant effect on the value of this feature of the bones tested. The average bone density took the following order: femur (1.23 g/cm3) <III metatarsal bone (1.26 g/cm3) <III metacarpal bone (1.34 g / cm3). The density of bones of animals fed aa libitum was higher (P<0.01) than in animals fed with a dosing system. The density of examined bones within the breeds took the following order: Pietrain race> line 990> Duroc race. The differences between the “extreme” breeds were: 7.2% (III metatarsal bone), 8.3% (III metacarpal bone), 8.4% (femur). Abstract 13 The average bone stiffness took the following order: III metatarsal bone (35.1 kg/mm) <III metacarpus (41.5 kg/mm) <femur (60.5 kg/mm). This indicator did not differ between the groups of pigs fed at different intensity, except for the metacarpal bone, which was more stiffer in pigs fed aa libitum (P<0.05). The femur of animals fed ad libitum showed a tendency (P<0.09) to be more stiffer and a force of 4.5 kg required for its displacement by 1 mm. Breed differences in stiffness were found for the femur (P <0.05) and III metacarpal bone (P <0.05). For femur, the highest value of this indicator was found in Pietrain pigs (64.5 kg/mm), lower in pigs of 990 line (61.6 kg/mm) and the lowest in Duroc pigs (55.3 kg/mm). In turn, the 3rd metacarpal bone of Duroc and Pietrain pigs had similar stiffness (39.0 and 40.0 kg/mm respectively) and was smaller than that of line 990 pigs (45.4 kg/mm). The thickness of the cortical bone layer took the following order: III metatarsal bone (2.25 mm) <III metacarpal bone (2.41 mm) <femur (5.12 mm). The feeding system did not affect this indicator. Breed differences (P <0.05) for this trait were found only for the femur bone: Duroc (5.42 mm)> line 990 (5.13 mm)> Pietrain (4.81 mm). The cross sectional area of the examined bones was arranged in the following order: III metatarsal bone (84 mm2) <III metacarpal bone (90 mm2) <femur (286 mm2). The feeding system had no effect on the value of this bone trait, with the exception of the femur, which in animals fed the dosing system was 4.7% higher (P<0.05) than in pigs fed ad libitum. Breed differences (P<0.01) in the coross sectional area were found only in femur and III metatarsal bone. The value of this indicator was the highest in Duroc pigs, lower in 990 animals and the lowest in Pietrain pigs. The cortical index of individual bones was in the following order: III metatarsal bone (31.86) <III metacarpal bone (33.86) <femur (44.75). However, its value did not significantly depend on the intensity of feeding or the breed of pigs.
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