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Journal articles on the topic 'Synthesis of nitrosyl compound'

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Published: 4 June 2021
Last updated: 10 February 2022

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1

De Vries, Nadine, Jessica Cook, Alan Davison, Terrence Nicholson, and Alun G. Jones. "Synthesis and characterization of a technetium(III) nitrosyl compound: Tc(NO)(Cl)(SC10H13)3." Inorganic Chemistry 29, no. 5 (March 1990): 1062–64. http://dx.doi.org/10.1021/ic00330a030.

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2

Legzdins, Peter, Kevin M. Smith, and Steven J. Rettig. "Synthesis, characterization, and properties of some cyclopentadienyl molybdenum nitrosyl benzyl complexes." Canadian Journal of Chemistry 79, no. 5-6 (May 1, 2001): 502–9. http://dx.doi.org/10.1139/v00-158.

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Reaction of CpMo(NO)(CH2Ph)Cl with Me2Mg, Ph2Mg, or PhCCLi reagents in THF affords the corresponding alkyl, aryl, or alkynyl CpMo(NO)(CH2Ph)R (R = hydrocarbyl) complexes as orange powders in good yields. Unlike related 16-electron CpMo(NO)R2 complexes, these 18-electron species exhibit good thermal stability due to their η2-benzyl-Mo interactions. Treatment of CpMo(NO)(CH2Ph)Cl with Na(DME)Cp provides dark green Cp2Mo(NO)(CH2Ph), whose solid-state molecular structure has been established by a single-crystal X-ray crystallographic analysis. The two Cp rings display different binding modes to the Mo atom, while the benzyl ligand is coordinated to the metal centre in an η1 fashion. The triflate complex, CpMo(NO)(CH2Ph)(OTf), is obtained by addition of AgOTf to the benzyl chloride precursor. The covalent Mo—OTf bond in this compound can be disrupted by the addition of Lewis bases (L) such as PPh3 or pyridine, leading to the corresponding [CpMo(NO)(CH2Ph)(L)][OTf] salts. Attempts to generate neutral benzylidene complexes by deprotonation of [CpMo(NO)(CH2Ph)(PPh3)][OTf] have not yet been successful.Key words: nitrosyl, molybdenum, benzyl, hydrocarbyl, triflate.
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3

Vogel, Sabine, Gottfried Huttner, Laszlo Zsolnai, and Christiane Emmerich. "H2NNH- und H2NO- als η2-koordinierte Liganden in Tripod-Cobalt-Komplexen / H2NNH- and H2NO- as η2-Coordinated Ligands in Tripod Cobalt Complexes." Zeitschrift für Naturforschung B 48, no. 3 (March 1, 1993): 353–63. http://dx.doi.org/10.1515/znb-1993-0315.

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The complex cation [tripod Co η2-(NH2O)]+, 2, (tripod = CH3C(CH2PPh2)3) containing an η2-coordinated NH2O−-ligand is an isoelectronic equivalent to the recently reported complex [tripod Co η2-(Ν2Η3)]+, 1, which contains side-on coordinated N2H3− [1,4]. The structures of the two cations 1 and 2 are almost superimposable.The structural discrimination between the NH2- and O- parts of the η2-NH2O--ligand in 2 has been corroborated by the synthesis and X-ray analysis of the cations [tripod Co η2-(NMe2O)]+, 3, and [tripod Co Cl (NH2OMe)]+, 4. The hydroxylamido(1–) compound 2 upon treatment with air transforms into the nitrosyl compound [tripod Co (NO)], 5, the structure of which has also been determined.
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4

Balasekaran, S. M., A. Hagenbach, M. Drees, and U. Abram. "[TcII(NO)(trifluoroacetate)4F]2−– synthesis and reactions." Dalton Trans. 46, no. 39 (2017): 13544–52. http://dx.doi.org/10.1039/c7dt03084c.

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Cs(NBu4)[Tc(NO)(OOCCF3)4F] can act as a precursor for the synthesis of further Tc(ii) and Tc(i) nitrosyl complexes with trifluoroacetato or fluorido ligands. The Tc(i) compounds show unusual99Tc NMR chemical shifts.
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Pratihar, Pampa, Anup Kumar Dasmahapatra, and Chittaranjan Sinha. "Arylazoimidazole compounds of rhenium nitrosyl: Synthesis, spectral characterization and reactivity." Polyhedron 26, no. 6 (April 2007): 1217–21. http://dx.doi.org/10.1016/j.poly.2006.10.029.

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6

Klimochkin, Yuri, Ilya Tkachenko, and Victor Rybakov. "Convenient Synthesis of Ethyl 5-Oxohomoadamantane-4-carboxylate: A Useful Precursor of Polyfunctional Homoadamantanes." Synthesis 51, no. 06 (November 8, 2018): 1482–90. http://dx.doi.org/10.1055/s-0037-1610312.

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A facile and convenient synthesis of ethyl 5-oxohomoadamantane-4-carboxylate is reported, and its chemical properties as a cage analogue of acetoacetic ester are investigated. Various derivatives of homoadamantane were synthesized through the reaction of 5-oxohomoadamantane-4-carboxylate with electrophilic agents, binucleophiles, and hydrazoic acid. Some new unusual products were obtained by the reaction of that β-keto ester with nitric acid and nitrosyl chloride. Cage compounds synthesized could be used as precursors for the diverse condensed heterocyclic compounds with potential viral ion channel abrogating activity that possess conformationally rigid lipophilic moieties.
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7

Keerthi Kumar, Chinnagiri T., Jathi Keshavayya, Tantry N. Rajesh, Sanehalli K. Peethambar, and Angadi R. Shoukat Ali. "Synthesis, Characterization, and Biological Activity of 5-Phenyl-1,3,4-thiadiazole-2-amine Incorporated Azo Dye Derivatives." Organic Chemistry International 2013 (August 18, 2013): 1–7. http://dx.doi.org/10.1155/2013/370626.

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5-Phenyl-1,3,4-thiadiazole-2-amine has been synthesized by single step reaction. A series of heterocyclic azodyes were synthesized by diazotisation of 5-phenyl-1,3,4-thiadiazole-2-amine by nitrosyl sulphuric acid followed by coupling with different coupling compounds such as 8-hydroxyquinoline, 2,6-diaminopyridine, 2-naphthol, N,N-dimethyl aniline, resorcinol, and 4,6-dihydroxypyrimidine. The dyes were characterized by UV-Vis, IR, 1H-NMR, 13C NMR, and elemental analysis. The synthesized compounds were also screened for biological activity.
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8

Vassilyeva, O., E. Buvaylo, and B. Skelton. "DIRECT SYNTHESIS AND CRYSTAL STRUCTURE OF BIS(BROMIDO-BIS(1,10 PHENANTHROLINE)-COPPER(II)) NITROPRUSSIDE DIMETHYLFORMAMIDE SOLVATE." Bulletin of Taras Shevchenko National University of Kyiv. Chemistry, no. 1(55) (2018): 15–18. http://dx.doi.org/10.17721/1728-2209.2018.1(55).3.

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The title compound, [Cu(C12H8N2)2Br]2[Fe(CN)5(NO)]·C3H7NO, was prepared by the self-assembly of nitroprusside anion and Cu cation containing a bidentate amine in the reaction of copper powder and sodium nitroprusside with NH4Br and 1,10-phenanthroline (phen) in dimethylformamide (DMF). The complex is formed of discrete [Cu(phen)2Br]+ cations, nitroprusside [Fe(CN)5(NO)]2– anions and DMF molecules of crystallization. The cation has no crystallographically imposed symmetry; the metal atom coordinates two nitrogen atoms of two phen molecules and bromide ion. The copper coordination geometry is intermediate between a square pyramid and a trigonal bipyramid. The [Fe(CN)5(NO)]2– anion is located on an inversion centre with the nitrosyl group modelled as disordered with one of the CN groups. The DMF solvent molecule was found to be disordered about the crystallographic inversion centre; geometries were restrained to ideal values. In the solid state, alternating layers of cations and of anions plus DMF molecules are stacked along the b axis.
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9

Vogler, Stefan, Kurt Dehnicke, and Dieter Fenske. "[Na-15-Krone-5] [ReF2Cl2(NO)2]; Synthese, IR-Spektrum und Kristallstruktur / [Na-15-Crown-5][ReF2Cl2(NO)2]; Synthesis, IR Spectrum, and Crystal Structure." Zeitschrift für Naturforschung B 44, no. 11 (November 1, 1989): 1393–96. http://dx.doi.org/10.1515/znb-1989-1112.

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[Na-15-crown-5][ReF2Cl2(NO)2] has been prepared by the reaction of ReCl3(NO)2 with sodium fluoride in acetonitrile suspension in the presence of 15-crown-5. It forms green, slightly moisture sensitive crystals, which were characterized by IR spectroscopy as well as by an X-ray structure determination. Space group P21/c, Z = 4, 4821 observed unique reflexions, R = 0.040. Lattice dimensions at —60 °C: a = 1024.6(7), b = 801.4(4), c = 2386.6(12) pm; β = 99.90(4)°. The compound forms ion pairs via two Na—F contacts with bond lengths of 239.8 and 233.4 pm. Thus the sodium ion is seven-coordinate by the five oxygen atoms of the crown ether molecule and by two fluorine ligands of the [ReF2Cl2(NO)2]- unit. The nitrosyl groups of the anion are in transposition to the fluorine atoms and in cis-position to one another (symmetry C2v).
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10

Smékal, Zdeněk, Jiří Kameníček, Ingrid Svoboda, and Albert Escuer. "Synthesis, Crystal Structure and Magnetic Properties of Novel Complex [μ-(NC)-Fe(CN)3(NO)-μ-(CN)-Cu(ept)]n·4nH2O (ept = N-(2-Aminoethyl)propane-1,3-diamine)." Collection of Czechoslovak Chemical Communications 66, no. 10 (2001): 1490–98. http://dx.doi.org/10.1135/cccc20011490.

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The novel complex [μ-(NC)-Fe(CN)3(NO)-μ-(CN)-Cu(ept)]n·4nH2O (ept = N-(2-aminoethyl)- propane-1,3-diamine) was obtained by the reaction of Cu(ClO4)2·6H2O with N-(2-amino- ethyl)propane-1,3-diamine and Na2[Fe(CN)5NO]·2H2O in water. This compound was characterized by IR, UV-VIS and EPR spectroscopies and magnetic measurement. Single-crystal X-ray structure analysis revealed that the title complex has a one-dimensional polymeric structure containing hexacoordinate iron(II) with five cyanide ligands (two of them, in trans position, bridging) and one nitrosyl group, and pentacoordinate copper(II) with N-(2-aminoethyl)propane-1,3-diamine and two sites occupied by bridging cyanide ligands. Magnetic investigation revealed a very weak antiferromagnetic interaction between the copper atoms (superexchange interaction parameter J = -1.7(1) cm-1; H = -JSiSi+1) within the chain through the diamagnetic [Fe(CN)5NO]2- ions.
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11

Lin, Shie-Hsiung, Shie-Ming Peng, and Rai-Shung Liu. "Molybdenum-mediated synthesis of isoxazole compounds through a nitrosyl insertion into a π-allyl ligand." J. Chem. Soc., Chem. Commun., no. 8 (1992): 615–17. http://dx.doi.org/10.1039/c39920000615.

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12

Qin, Xiang-Yang, Gui-Rong Ding, Xiao-Wu Wang, Juan Tan, Guo-Zhen Guo, and Xiao-Li Sun. "Synthesis, characterisation, cytotoxicity and radioprotective effect of novel chiral nitronyl nitroxyl radicals." Journal of Chemical Research 2009, no. 8 (August 2009): 511–14. http://dx.doi.org/10.3184/030823409x12474221035163.

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Nitroxyl compounds have been previously investigated as potential radioprotection drugs. To develop new radioprotectors, two kinds of novel chiral nitronyl nitroxyl radicals: L- tert-butyl 2-(4, 5-dihydro-4, 4, 5, 5-tetramethyl-3-oxido-1 H-imidazol-3-ium-1-oxyl-2-yl) pyrrolidine-1-carboxylate ( L-NNP) and L- tert-butyl 2-[(4-(4, 5-dihydro-4,4,5,5-tetramethyl-3-oxido-1 H-imidazol-3-ium-1-oxyl-2-yl)-2-methoxyphenoxy)methyl] pyrrolidine-1-carboxylate ( L-NNVP) have been synthesised. The cytotoxic and radioprotective effects of these two compounds were then evaluated in rat glioma C6 cells.
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13

Gowenlock, Brian, and Thomas Sharpe. "Synthesis of Nitroso- and Dinitroso Compounds by Reaction of Nitrosyl Benzoate and Dinitrosylterephthalate with Tetrasubstituted Alkenes." Synthesis 2006, no. 12 (June 2006): 1991–94. http://dx.doi.org/10.1055/s-2006-942392.

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14

Voronkov, Andrey, and Dmitry Pozdnyakov. "Endothelotropic Activity of 4-Hydroxy-3,5-Di-Tret-Butylcinnamic Acid in the Conditions of Experimental Cerebral Ischemia." Research Results in Pharmacology 4, no. 2 (July 19, 2018): 1–10. http://dx.doi.org/10.3897/rrpharmacology.4.26519.

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Introduction: The aim of the study was to evaluate the endothelioprotective activity of 4-hydroxy-3,5-di-tret-butylcinnamic acid in conditions of experimental cerebral ischemia. Materials and Methods: The brain ischemia was reproduced by the method of irreversible right-sided thermocoagulation of the middle cerebral artery. As comparative drugs, mexidol (30 mg/kg) and sulodexide (30 U/kg) were used. The vasodilating function of the vascular endothelium was assessed by the change in the rate of cerebral blood flow when the synthesis of nitric oxide was modified. Antithrombotic function was assessed by changes in the concentration of thromboxane A2, fibrinogen, von Willebrand factor activity and platelet aggregation activity. Serum concentration of C-reactive protein served as a marker of the state of anti-inflammatory endothelial function. To determine the potential mechanism of endothelioprotective activity of 4-4-hydroxy-3,5-di-tret-butylcinnamic acid, the anti-radical activity of this compound toward superoxide and nitrosy-radicals was assessed; and the effect of the compound on the mitochondrial function was studied, by evaluating the functional activity of mitochondrial ATP synthetase and cytochrome-c-oxidase by ELISA. Results and Discussion: In the course of the study, a positive effect of 4-hydroxy-3,5-di-tret-butylcinnamic acid on the state of endothelial function in cerebral ischemia was established, which was expressed in the preservation of vasodilating (restoring the vascular reaction to acetylcholine, nitro-L-arginine methyl ether, L-arginine), antithrombotic (a decrease in the concentration of thromboxane A2, fibrinogen and von Willebrand factor activity by 241.9% (p <0.05), 73.5% (p <0.05), 20.4% (p <0.05), respectively, a decrease in the degree of aggregation and platelet aggregation rate by 56.7 % (p <0.05) and 52.8% (p <0.05), respectively, and anti-inflammatory vascular endothelial function (99.1% C-reactive protein reduction (p <0.05)). The 4-hydroxy-3,5-di-tret-butylcinnamic acid compound in vitro tests suppressed generation of superoxide (IC50 = 1.99 mg/ml) and nitrosyl radical (IC50 = 1.92 mg/ml), eliminated NO-synthase uncoupling, and restored the mitochondrial function (increase in mitochondrial ATP synthase and cytochrome-c-oxidase activity by 23.5% (p <0.05) and 110.8% (p <0.05), respectively). Conclusion: The study demonstrated the presence of endotheliotropic activity of 4-hydroxy-3,5-di-tret-butylcinnamic acid, which is expressed in the preservation of vasodilating, antithrombotic and anti-inflammatory functions of the vascular endothelium in conditions of cerebral ischemia. At the same time, the anti-radical properties of this compound, as well as the direct effect on the functional activity of the NO-synthase system and the improvement of the mitochondrial function, may underlie the endotheliotropic effects of 4-hydroxy-3,5-di-tret-butylcinnamic acid.
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15

LIN, S. H., S. M. PENG, and R. S. LIU. "ChemInform Abstract: Molybdenum-Mediated Synthesis of Isoxazole Compounds Through a Nitrosyl Insertion into a π-Allyl Ligand." ChemInform 23, no. 39 (August 21, 2010): no. http://dx.doi.org/10.1002/chin.199239189.

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16

Tao, Fangqi, Junjie Li, and Qi Wang. "Aqueous radical addition-coupling polymerization for the synthesis of hydrophilic periodic polymer." RSC Adv. 4, no. 95 (2014): 53253–56. http://dx.doi.org/10.1039/c4ra06400c.

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A hydrophilic polymer possessing a [ABxAC]n (A = ester, B = ethylene oxide, C = N–O) repeating sequence was synthesized by an aqueous radical addition-coupling polymerization using water-soluble dibromide and a nitroso compound in the presence of a CuBr/ligand.
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17

Sellmann, Dieter, and Gerhard Binker. "Übergangsmetall-Komplexe mit Schwefelliganden, XXVII Synthese und Reaktivität der Nitrosyl-und Nitrido-Ruthenium-Komplexe mit 1,2-Benzoldithiolat-Liganden [Ru(NO)(S2C6H4) 2]- bzw. [Ru(N)(S2C6H4)2]- / Transition Metal Complexes with Sulfur Ligands, XXVII Synthesis and Reactivity of the Nitrosyl- and Nitrido-Ruthenium Complexes with 1,2-Benzenedithiolate Ligands [Ru(NO)(S2C6H4)2]- and [Ru(N)(S2C6H4)2]-, Respectively." Zeitschrift für Naturforschung B 42, no. 3 (March 1, 1987): 341–47. http://dx.doi.org/10.1515/znb-1987-0316.

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The reaction of [Ru(NO)2(PPh3)2], [RuCl(NO)2(PPh3)2]PF6 or [RuCl3(NO)(PPh3)2] with 1,2- benzenedithiolate(-2), C6H4S22-, leads to the 16e--complex [Ru(NO)(S2C6H4)2]-, which was isolated as the NBu4+ salt (1). The square pyramidal anion in [NBu4)[Ru(NO)(S2C6H4)2] coordinates PMe3 with rearrangement of the sulfur ligands to give the six-coordinate cis- [NBu4][Ru(NO)(PMe3)(S2ChH4)2] (3); the rearrangement of the C6H4S22--Iigands from trans to cis coordination is proved by 13C NMR spectroscopy. [Ru(NO)(S2C6H4)2]- is rapidly reduced even under mild conditions. Reaction of 1 with NaBH4 in MeOH leads to the reduction of NO to a nitrido ligand and the concomitant oxidation of (formal) Ru(III) to Ru(VI) yielding [NBu4][Ru(N)(S2C6H4)2] (2). This compound is also formed when the nitrosyl complex is reacted withSiMe3N3.[Ru(NO)2(PPh3)2] and [RuCl(NO)2(PPh3)2]PFare denitrosylated by dttd2- (dttd2- = 2,3,8,9-dibenzo-1,4,7,10-tetrathiadecane(-2)) to give [Ru(dttd)(PPh3)2]
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18

de Carvalho, Leandro Lara, Robert Alan Burrow, and Vera Lúcia Patrocinio Pereira. "Diastereoselective synthesis of nitroso acetals from (S,E)-γ-aminated nitroalkenes via multicomponent [4 + 2]/[3 + 2] cycloadditions promoted by LiCl or LiClO4." Beilstein Journal of Organic Chemistry 9 (April 30, 2013): 838–45. http://dx.doi.org/10.3762/bjoc.9.96.

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Chiral nonracemic aminated nitroso acetals were synthesized via diastereoselective multicomponent [4 + 2]/[3 + 2] cycloadditions employing new (S,E)-γ-nitrogenated nitroalkenes 5a–c as heterodienes, ethyl vinyl ether (EVE) as a dienophile, and selected electron-deficient alkenes as 1,3-dipolarophiles. The employment of different organic solutions of LiClO4 or LiCl as promoter systems provided the respective nitroso acetals with yields from 34–72% and good levels of diastereoselectivity. In addition, the nitroso acetal 9c was transformed to the pyrrolizidin-3-one derivative 14c, proving the usefulness of the route in the synthesis of an interesting chiral compound. The elucidation of the stereostructures was based on 2D COSY, NOESY and HSQC NMR experiments as well as an X-ray diffraction experiment.
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19

Mahmoudpour, Asiyeh, Shohreh Nafisi, Ezzatollah Najafi, and Behrouz Notash. "Synthesis, characterization and electroluminescence properties of a new mixed-ligand diorganotin(IV) complex." Main Group Metal Chemistry 42, no. 1 (June 24, 2019): 51–59. http://dx.doi.org/10.1515/mgmc-2019-0005.

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Abstract A new mixed-ligand diorganotin(IV) complex, [μ-(4-dpe){Me2Sn(cup)2}2] (1), was synthesized by reacting dimethyltin(IV) dichloride with 1,2-di(4-pyridyl)ethylene (4-dpe) and ammonium N-Nitroso-N-phenylhydroxylamine (cup). The prepared complex was fully characterized by PXRD, 1H, 13C and 119Sn NMR, IR, and UV spectra and elemental analysis (CHN). The structural analysis of complex 1 by X-ray diffraction showed that this compound consists of centrosymmetric binuclear units that crystallize in the monoclinic system with the space group of P21/c. Thermal behavior of this complex was interrogated by thermogravimetric and differential thermal analysis (TGA and DTA) under air atmosphere. The study of thermal behavior and luminescence properties of prepared diorganotin(IV) complex exhibited that this complex can be used as a emitting layer in the preparation of optical devices. The prepared coordination compound was used in two different concentrations in the manufacture of two light-emitting diodes (OLEDs).
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Chen, Jing, You-Juan Zhang, Kun-Tao Huang, and Qiang Huang. "Synthesis and characterization of a ladder-like structure compound formed by cadmium (II) and anionic nitronyl nitroxide." Open Journal of Inorganic Chemistry 03, no. 03 (2013): 55–58. http://dx.doi.org/10.4236/ojic.2013.33008.

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21

Szkatuła, Dominika, Edward Krzyżak, Paulina Stanowska, Magdalena Duda, and Benita Wiatrak. "A New N-Substituted 1H-Isoindole-1,3(2H)-Dione Derivative—Synthesis, Structure and Affinity for Cyclooxygenase Based on In Vitro Studies and Molecular Docking." International Journal of Molecular Sciences 22, no. 14 (July 18, 2021): 7678. http://dx.doi.org/10.3390/ijms22147678.

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Isoindoline-1,3-dione derivatives constitute an important group of medicinal substances. In this study, nine new 1H-isoindole-1,3(2H)-dione derivatives and five potential pharmacophores were obtained in good yield (47.24–92.91%). The structure of the new imides was confirmed by the methods of elemental and spectral analysis: FT–IR, H NMR, and MS. Based on the obtained results of ESI–MS the probable path of the molecules decay and the hypothetical structure of the resulting pseudo-molecular ions have been proposed. The physicochemical properties of the new phthalimides were determined on the basis of Lipiński’s rule. The biological properties were determined in terms of their cyclooxygenase (COX) inhibitory activity. Three compounds showed greater inhibition of COX-2, three compounds inhibited COX-1 more strongly than the reference compound meloxicam. From the obtained results, the affinity ratio COX-2/COX-1 was calculated. Two compounds had a value greater than that of meloxicam. All tested compounds showed oxidative or nitrosan stress (ROS and RNS) scavenging activity. The degree of chromatin relaxation outside the cell nucleus was lower than the control after incubation with all test compounds. The newly synthesized phthalimide derivatives showed no cytotoxic activity in the concentration range studied (10–90 µM). A molecular docking study was used to determined interactions inside the active site of cyclooxygenases.
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Zhao, Qi-Hua, Li-Cun Li, Zong-Hui Jiang, Dai-Zheng Liao, Shi-Ping Yan, and Rui-Bin Fang. "Synthesis and structure of a novel one-dimensional chain compound formed by copper(II) and nitronyl nitroxide radical." Journal of Chemical Crystallography 34, no. 3 (March 2004): 191–94. http://dx.doi.org/10.1023/b:jocc.0000021563.00957.85.

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23

Matmin, Juan, Leny Yuliati, Mustaffa Shamsuddin, and Hendrik Oktendy Lintang. "Supramolecular Hydrogen Bonding Interactions of Novel 1,3,5-Benzenetricarbonyl Trisubstituted Alkyl for Anion Sensor Applications." Advanced Materials Research 925 (April 2014): 228–32. http://dx.doi.org/10.4028/www.scientific.net/amr.925.228.

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Herein we report the first example of benzene-1,3,5-tricarboxamide bearing hydrophobic aminododecane side chains (1) which spontaneously forms supramolecular network by a hydrogen bonding interaction. The compound 1 was synthesized by Schotten-Baumann reaction of 1,3,5-benzenetricarbonyl trichloride and 1-aminododecane in the presence of N,N-diisopropylethylamine. Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS), and Fourier Transform Infrared (FTIR) spectroscopies have proved the successful synthesis of 1 in 93% as white powder solid. The supramolecular organization was successfully utilized for sensing of nitrate anions by deformation of the hydrogen bonding to form inactive nitroso groups.
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24

Lee, Jonghyuk, Geun-Bae Yi, Douglas R. Powell, Masood A. Khan, and George B. Richter-Addo. "Synthesis, characterization, and protonation of octaethylporphyrin osmium nitrosyl complexes containing axial thiolate ligands - X-ray structures of an alkyl thionitrite (RSNO) and its (OEP)Os(NO)(SR) addition product." Canadian Journal of Chemistry 79, no. 5-6 (May 1, 2001): 830–40. http://dx.doi.org/10.1139/v00-168.

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The (OEP)Os(NO)(SR) compounds (R = Me, Et, i-Pr, t-Bu) have been prepared in 33-48% isolated yields by the formal trans-addition of the precursor alkyl thionitrites (RSNO) across the metal center in (OEP)Os(CO). The nitrosyl thiolate compounds have been characterized by IR, 1H NMR, and UV-vis spectroscopy, and by FAB mass spectrometry. Their IR spectra display bands in the 1751-1755 cm-1 (KBr) range, which is indicative of terminal N-bound NO ligands in this class of compounds. The thiolate-thiol (OEP)Os(NO)(SCH2CH2SH) complex has been prepared in 70% isolated yield from the reaction of (OEP)Os(NO)(O-i-C5H11) with ethane-1,2-dithiol. Nitrosation of the free -SH group in (OEP)Os(NO)(SCH2CH2SH) with t-BuONO, followed by reaction with (TTP)Ru(CO) gave [(OEP)Os(NO)](µ-SCH2CH2S-S,S')[Ru(NO)(TTP)] in 70% yield by 1H NMR spectroscopy. The (OEP)Os(NO)(SCR'2CH2NHC(O)Me) compounds have also been prepared either by an alkoxide-thiolate exchange reaction (for R' = H) or by RSNO addition to (OEP)Os(CO) (for R' = Me). The solid-state molecular structures of the precursor RSNO thionitrite (for R' = Me) and the metalloderivative have been determined by single-crystal X-ray crystallography. Protonation of these (OEP)Os(NO)(SCR'2CH2NHC(O)Me) complexes gave the amide-bound [(OEP)Os(NO)(O=C(Me)NHCH2CR'2SH)]BF4 derivatives. The latter cationic compounds were also obtained by the sequential reaction of (OEP)Os(CO) with nitrosonium tetrafluoroborate, followed by addition of the amide-thiol reagent. Key words: thionitrite, nitrosothiol, porphyrin, X-ray structure, nitric oxide, osmium.
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25

Leal, Felipe A., Ivan M. Lorkovic, Peter C. Ford, Jonghyuk Lee, Li Chen, Lindsey Torres, Masood A. Khan, and George B. Richter-Addo. "Synthesis, characterization, and molecular structures of nitrosyl nitrito complexes of osmium porphyrins: Disproportionation of nitric oxide in its reaction with Os(P)(CO) (P = porphyrinato dianion)." Canadian Journal of Chemistry 81, no. 7 (July 1, 2003): 872–81. http://dx.doi.org/10.1139/v03-091.

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The Os(P)(NO)(ONO) compounds (P = TTP, TMP, OEP, TmTP; TTP = 5,10,15,20-tetra-p-tolylporphyrinato dianion, TMP = 5,10,15,20-tetramesitylporphyrinato dianion, OEP = octaethylporphyrinato dianion, TmTP = tetra(m-tolyl)porphyrinato dianion) have been prepared from the reaction of the precursor carbonyl complexes Os(P)(CO) with excess nitric oxide. Nitrous oxide was detected as a by-product of the reaction. The IR spectra of the Os(P)(NO)(ONO) compounds (as KBr pellets) reveal bands in the 1790–1804 cm–1 range that are assigned to υNO. The IR spectra also reveal two new bands for each complex in the 1495–1531 and 913–962 cm–1 ranges indicative of O-bound nitrito ligands. The linearity of the bound NO groups and the O-binding of the trans nitrito ligands in the Os(P)(NO)(ONO) complexes are evident in the single-crystal X-ray crystal structures of the TTP and TMP derivatives. The kinetics of the reaction were studied by stopped-flow mixing techniques. Spectroscopic analysis of rapidly mixed solutions of Os(P)CO and NO in toluene showed a biphasic approach to the Os(P)(NO)(ONO) and N2O products, owing to the starting material Os(P)CO scavenging CO formed during the reaction to give Os(P)(CO)2 (KCO = 106 M–1). The dicarbonyl was the only transient species observed. It is proposed that the rate-determining step of the reaction leading to Os(P)(NO)(ONO) is NO displacement of CO from Os(P)(CO) via initial formation of an unstable 19 electron Os(P)(NO)(CO) intermediate.Key words: osmium, nitric oxide, X-ray, nitrosyl, porphyrin, kinetics.
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26

Zakrzewski, Jerzy. "Reactions of nitroxides XIII: Synthesis of the Morita–Baylis–Hillman adducts bearing a nitroxyl moiety using 4-acryloyloxy-2,2,6,6-tetramethylpiperidine-1-oxyl as a starting compound, and DABCO and quinuclidine as catalysts." Beilstein Journal of Organic Chemistry 8 (September 12, 2012): 1515–22. http://dx.doi.org/10.3762/bjoc.8.171.

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27

Chang, Jeffrey, Mark D. Seidler, and Robert G. Bergman. "Synthesis of alkylruthenium nitrosyl complexes. Migratory insertion to coordinated nitric oxide and the mechanism of the conversion of the resultant nitrosoalkyl compounds to oximate, carboxamide, and cyano compounds." Journal of the American Chemical Society 111, no. 9 (April 1989): 3258–71. http://dx.doi.org/10.1021/ja00191a024.

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28

Furukawa, T., H. Kohno, R. Tokunaga, and S. Taketani. "Nitric oxide-mediated inactivation of mammalian ferrochelatase in vivo and in vitro: possible involvement of the iron-sulphur cluster of the enzyme." Biochemical Journal 310, no. 2 (September 1, 1995): 533–38. http://dx.doi.org/10.1042/bj3100533.

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To investigate the role of the iron-sulphur cluster in mammalian ferrochelatases, the terminal enzyme of the haem biosynthetic pathway, we examined the interaction of nitric oxide (NO) and ferrochelatase. When macrophage cell line RAW 264.7 cells were treated with interferon-gamma and lipopolysaccharide NO synthesis in the cells was stimulated, and a decrease in ferrochelatase activity was observed, with no change in the amount of ferrochelatase. The addition of NG-monomethyl-L-arginine, a selective inhibitor of NO synthesis, reduced the effect of interferon-gamma and lipopolysaccharide, while the effect of NG-monomethyl-L-arginine was suppressed by the addition of L-arginine, a substrate of NO synthase. When purified recombinant human ferrochelatase was treated with 3-morpholinosydnonimine, a NO-generating compound, ferrochelatase activity decreased with disappearance of characteristic absorbance spectra of the iron-sulphur cluster. S-Nitroso-N-acetylpenicillamine also reduced the activity, in a dose-dependent manner. These results indicate that ferrochelatase activity can be modulated by NO synthesis probably through disruption of the iron-sulphur cluster. We propose that inactivation of ferrochelatase mediated by NO (or NO-derived species) may play a role in the regulation of haem metabolism.
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29

Li, Lei-Lei, Shuang Liu, Yuan Zhang, Wei Shi, and Peng Cheng. "Three new mononuclear tri-spin lanthanide-nitronyl nitroxide radical compounds: syntheses, structures and magnetic properties." Dalton Transactions 44, no. 13 (2015): 6118–25. http://dx.doi.org/10.1039/c4dt03941f.

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30

Marano, Stefania, Cristina Minnelli, Giovanna Mobbili, Emiliano Laudadio, and Pierluigi Stipa. "Synthesis and Evaluation of New Nitrone-Based Benzoxazinic Antioxidants." Medical Sciences Forum 2, no. 1 (November 30, 2020): 17. http://dx.doi.org/10.3390/cahd2020-08610.

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Oxidative stress is often the cause of a wide range of human chronic pathologies including, but not limited to, stroke and cardiovascular and neurodegenerative diseases. In this setting, increasing efforts are currently being devoted to the design and synthesis of new derivatives with enhanced antioxidant efficacy. Among all the potential molecules of interest, synthetic nitrone spin-traps have attracted a great deal of research attention, particularly due to their dual function as effective inhibitors of oxidative stress and damage and as analytical tools for the detection and characterization of free radicals by means of the electron paramagnetic resonance (EPR) spectroscopy spin trapping technique. In this study, two derivatives of benzoxazinic nitrones (3-aryl-2H-benzo[1,4]oxazin-N-oxides) bearing an electron-withdrawing methyl-acetate group on the benzo moiety (in para and meta positions with respect to the nitronyl function) were synthesized. Their in vitro antioxidant activity was evaluated by means of the α,α-diphenyl-β-picrylhydrazyl radical (DPPH) scavenging assay, and their inhibitory effects on the erythrocyte hemolysis induced by the water-soluble free radical initiator 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH) compared. In addition, EPR was employed to monitor the decay profiles of DPPH to evaluate the kinetic behavior of the different antioxidants tested. Results showed that the presence and the position of the electron-withdrawing methyl-acetate group strongly affects the radical scavenging activity of nitrones. In particular, the newly synthesized para-substituted derivative, when compared to both the meta-substituted isomer and the unsubstituted parent compound, acts as a more effective antioxidant both in cell and cell-free systems. Overall, these results clearly show that the introduction of an electron-withdrawing group on the phenyl moiety significantly increased the antioxidant capacity of benzoxazinic nitrones, thus showing exciting opportunities in the search for new therapeutic agents in the treatment of diseases associated with oxidative stress.
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31

Esteve-Núñez, Abraham, Antonio Caballero, and Juan L. Ramos. "Biological Degradation of 2,4,6-Trinitrotoluene." Microbiology and Molecular Biology Reviews 65, no. 3 (September 1, 2001): 335–52. http://dx.doi.org/10.1128/mmbr.65.3.335-352.2001.

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SUMMARY Nitroaromatic compounds are xenobiotics that have found multiple applications in the synthesis of foams, pharmaceuticals, pesticides, and explosives. These compounds are toxic and recalcitrant and are degraded relatively slowly in the environment by microorganisms. 2,4,6-Trinitrotoluene (TNT) is the most widely used nitroaromatic compound. Certain strains of Pseudomonas and fungi can use TNT as a nitrogen source through the removal of nitrogen as nitrite from TNT under aerobic conditions and the further reduction of the released nitrite to ammonium, which is incorporated into carbon skeletons. Phanerochaete chrysosporium and other fungi mineralize TNT under ligninolytic conditions by converting it into reduced TNT intermediates, which are excreted to the external milieu, where they are substrates for ligninolytic enzymes. Most if not all aerobic microorganisms reduce TNT to the corresponding amino derivatives via the formation of nitroso and hydroxylamine intermediates. Condensation of the latter compounds yields highly recalcitrant azoxytetranitrotoluenes. Anaerobic microorganisms can also degrade TNT through different pathways. One pathway, found in Desulfovibrio and Clostridium, involves reduction of TNT to triaminotoluene; subsequent steps are still not known. Some Clostridium species may reduce TNT to hydroxylaminodinitrotoluenes, which are then further metabolized. Another pathway has been described in Pseudomonas sp. strain JLR11 and involves nitrite release and further reduction to ammonium, with almost 85% of the N-TNT incorporated as organic N in the cells. It was recently reported that in this strain TNT can serve as a final electron acceptor in respiratory chains and that the reduction of TNT is coupled to ATP synthesis. In this review we also discuss a number of biotechnological applications of bacteria and fungi, including slurry reactors, composting, and land farming, to remove TNT from polluted soils. These treatments have been designed to achieve mineralization or reduction of TNT and immobilization of its amino derivatives on humic material. These approaches are highly efficient in removing TNT, and increasing amounts of research into the potential usefulness of phytoremediation, rhizophytoremediation, and transgenic plants with bacterial genes for TNT removal are being done.
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32

Alloatti, Giuseppe, Claudia Penna, Filippo Mariano, and Giovanni Camussi. "Role of NO and PAF in the impairment of skeletal muscle contractility induced by TNF-α." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 279, no. 6 (December 1, 2000): R2156—R2163. http://dx.doi.org/10.1152/ajpregu.2000.279.6.r2156.

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The role of platelet-activating factor (PAF) and nitric oxide (NO) as mediators of the effects of tumor necrosis factor-α (TNF-α) on skeletal muscle contractility was studied in guinea pig extensor digitorum longus (EDL) muscle. TNF-α (5–10 ng/ml) reduced contractility at every stimulation frequency (1–200 Hz) and shifted the force-frequency relationship to the right. The role of NO and PAF as mediators of TNF-α was suggested by the protective effect of N G-nitro-l-arginine methyl ester (l-NAME; 1 mM), but not of N G-nitro-d-arginine methyl ester (d-NAME; 1 mM), and by the inhibitory effect of the PAF-receptor antagonist WEB-2170 (3 μM). TNF-α increased the production of PAF and NO. Similar to TNF-α, both S-nitroso- N-acetylpenicillamine (0.5–1 μM), an NO-generating compound, and PAF (10–20 nM) reduced EDL contractility. l-NAME, but not d-NAME, blocked the negative effect of PAF. Blockade of phospholipase A2, which is required for PAF synthesis, significantly reduced the effects of TNF-α. WEB-2170 inhibited NO synthesis induced by TNF-α and PAF-stimulated NO production. These results suggest that both PAF and NO contribute to the development of the mechanical alterations induced by TNF-α and that NO production is downstream to the synthesis of PAF.
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33

Horton, R. A., E. D. Ceppi, R. G. Knowles, and M. A. Titheradge. "Inhibition of hepatic gluconeogenesis by nitric oxide: a comparison with endotoxic shock." Biochemical Journal 299, no. 3 (May 1, 1994): 735–39. http://dx.doi.org/10.1042/bj2990735.

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Isolated hepatocytes incubated in the presence of the NO donors S-nitroso-N-acetylpenicillamine (SNAP) and 3-morpholino-sydnonimine (SIN-1) displayed a time- and dose-dependent inhibition of glucose synthesis from lactate plus pyruvate as the substrate which correlated with NO production, but not nitrite production. Neither the parent compound of SNAP, N-acetyl-DL-penicillamine (NAP), nor nitrite or nitrate had any significant effect on glucose output, indicating that the inhibition was due to the generation of NO within the incubation medium. The concentrations of NO required for this effect (< 800 nM) are within the range reported to occur in intact tissues and in vivo. The magnitude of the inhibitory effect of SNAP (approximately 50%) was comparable with that of endotoxin treatment of the rat with lactate plus pyruvate as the substrate. When the effect of SNAP on glucose synthesis and lactate plus pyruvate synthesis from a number of different substrates was examined, this showed a pattern comparable with that observed after endotoxin treatment of the rat, suggesting that NO may be the inhibitory mediator of the effects of bacterial endotoxin on hepatic gluconeogenesis. The NO donor had no effect on the flux through 6-phosphofructo-1-kinase, supporting the concept that the primary site of inhibition of gluconeogenesis by both NO and endotoxin resides at the level of phosphoenolpyruvate formation.
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34

Phillips, JD, DV Kinikini, Y. Yu, B. Guo, and EA Leibold. "Differential regulation of IRP1 and IRP2 by nitric oxide in rat hepatoma cells." Blood 87, no. 7 (April 1, 1996): 2983–92. http://dx.doi.org/10.1182/blood.v87.7.2983.bloodjournal8772983.

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Iron-regulatory proteins (IRP1 and IRP2) are RNA-binding proteins that bind to stem-loop structures known as iron-responsive elements (IREs). IREs are located in the 5′- or 3′-untranslated regions (UTRs) of specific mRNAs that encode proteins involved in iron homeostasis. The binding of IRPs to 5′ IREs represses translation of the mRNA, whereas the binding of IRPs to 3′ IREs stabilizes the mRNA. IRP1 and IRP2 binding activities are regulated by intracellular iron levels. In addition, nitric oxide (NO.) increases the affinity of IRP1 for IREs. The role of NO. in the regulation of IRP1 and IRP2 in rat hepatoma cells was investigated by using the NO.-generating compound S-nitroso-N- acetylpenicillamine (SNAP), or by stimulating cells with multiple cytokines and lipopolysaccharide (LPS) to induce NO. production. Mitochondrial and IRP1 aconitase activities were decreased in cells producing NO(.). NO. increased IRE binding activity of IRP1, but had no effect on IRE binding activity of IRP2. The increase in IRE binding activity of IRP1 was coincident with the translational repression of ferritin synthesis. Transferrin receptor (TfR) mRNA levels were increased in cells treated with NO.-generating compounds, but not in cytokine- and LPS-treated cells. Our data indicate that IRP1 and IRP2 are differentially regulated by NO. in rat hepatoma cells, suggesting a role for IRP1 in the regulation of iron homeostasis in vivo during hepatic inflammation.
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35

Burlakova, Elena, Elena Molochkina, and Grygoriy Nikiforov. "Hybrid antioxidants." Chemistry & Chemical Technology 2, no. 3 (September 15, 2008): 163–71. http://dx.doi.org/10.23939/chcht02.03.163.

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The article is a review of the data on synthesis and physiological activity of hybrid antioxidants. The introduction offers an explanation to the fact why, in some cases, it is necessary to add drug molecules with fragments responsible for various properties and aimed at various targets. A large group of hybrid antioxidants comprise stable nitroxyl radicals that behave as antioxidants in free-radical reactions of oxidation. Compounds of this type were synthesized extensively to form a group of antitumor agents. As a rule, the specific (antitumor) activity retained or even increased as compared with the initial compounds (without nitroxyl radicals); the toxicity decreased 5 to 10 times, which made it possible to apply the drug in considerably higher concentrations. There are reported data on nitroxyl derivatives of anthracycline antibiotics, antimetabolites, alkyl ting agents, and the recent results on platinum complexes with nitroxyl fragments. Much attention is given to hindered phenols with “buoyancy” properties, particularly, to biochemical effects, making them promising agents to treat Alzheimer’s disease.
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36

Khazaal, Fatma A., and Hussein J. Mohammed*. "Synthesis and solvatochromic of 3-(4-N-Pyridine -2-yl benzene sulfonamide azo)-1-nitroso naphthol and use it for determination of trace amount of Cobalt (II) as complex." International Journal of Bioassays 5, no. 09 (August 31, 2016): 4878. http://dx.doi.org/10.21746/ijbio.2016.09.0018.

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The azo reagent 3- (4-N-Pyridine -2-yl benzene sulfonamide azo)-1-nitroso naphthol was synthesized and characterized by FT-IR, 1H-NMR and 13CNMR spectral techniques. The solvatochromism of the azo compound was studied by using different solvents. Spectrophotometric determination of cobalt (II) is based on the formation of a 2:1 complex with above reagent. The complex has λmax at (452) nm and Ԑmax of (2. 0567*104) L. mol-1. cm-1.A linear correlation (0.1- 3.5μg. ml-1) was found between absorbance at λmax and concentration. The effect of diverse ions on the determination of cobalt (II) to investigate the selectivity of the method were also studied. The stability constant of the product was (2. 68*108). The proposed method was successfully applied to the analysis of honey sample.
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37

Kahn, Olivier, Andreas Lang, Yu Pei, and Lahcène Ouahab. "Synthesis, crystal structure, and magnetic properties of 5-methyl-l,2,4-triazole-nitronyl nitroxide: A one-dimensional compound with unusually large ferromagnetic intermolecular interactions." Advanced Materials 8, no. 1 (January 1996): 60–62. http://dx.doi.org/10.1002/adma.19960080111.

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38

Constantinescu, Titus, Petre Ionita, Ion Chiorescu, and Gabriela Ionita. "Hydrazyl, Nitronyl-, and imino-nitroxides: Synthesis, properties and reaction with nitric oxide and nitrogen dioxide." Open Chemistry 1, no. 4 (December 1, 2003): 465–76. http://dx.doi.org/10.2478/bf02475228.

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AbstractTen novel and stable free radicals of nitronyl-, imino-nitroxide and hydrazyl type compounds were synthesized and their physico-chemical properties investigated. UV-Vis and ESR spectroscopic data, as well as the lipophilicities and specific hydrophobic areas of the compounds are compiled. The reaction of these radical compounds with nitric oxide and nitrogen dioxide was also investigated. The radicals synthesized, show selectivity in their reaction with these nitric oxides, depending on their structure (nitronyl-nitroxide radicals react with NO, while hydrazyl radicals react with NO2). The processes are easily monitored by UV-Vis or ESR spectroscopy.
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39

Dana, Suman, Isai Ramakrishna, and Mahiuddin Baidya. "Ambident Reactivity of Nitroso Compounds for Direct Amination and Hydroxylation of Carbonyls." Synthesis 49, no. 15 (July 17, 2017): 3281–90. http://dx.doi.org/10.1055/s-0036-1590793.

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Functionalization of carbonyls, particularly with a heteroatom subunit, is an important synthetic transformation. Utilization of ambident electrophiles for such a strategy is advantageous because two different heteroatom units can be installed from a single source under judicial reaction conditions. Recently, there have been increased examples for the construction of C–O and C–N bonds using nitroso compounds, a prototype of ambident electrophiles. In this short review, we discuss the advantages and challenges of exploiting nitroso compounds in organic synthesis with specific focus on nitroso aldol type processes for the direct hydroxylation and amination of carbonyl compounds.1 Introduction2 Prime Challenges in Nitroso Aldol Reactions3 Direct Hydroxylation Reactions4 Direct Amination Reactions5 Conclusion and Outlook
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40

Cappelli-Bigazzi, M., D. W. Nuno, and K. G. Lamping. "Evidence of a role for compounds derived from arginine in coronary response to serotonin in vivo." American Journal of Physiology-Heart and Circulatory Physiology 261, no. 2 (August 1, 1991): H404—H409. http://dx.doi.org/10.1152/ajpheart.1991.261.2.h404.

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Recent studies have demonstrated that a nitroso compound derived from L-arginine (Arg) may be the endothelium-derived relaxing factor (EDRF) released from vascular endothelium. Synthesis of EDRF from L-Arg is inhibited by analogues of Arg such as NG-monomethyl-L-arginine (L-NMMA) and N omega-nitro-L-arginine (L-NNA). We tested the role of compounds derived from Arg in the constriction of the proximal left anterior descending coronary artery (LAD) to serotonin in vivo by measuring responses before and during infusion of L-NMMA or L-NNA. In open-chest anesthetized dogs the LAD was perfused at constant pressure (80 mmHg) from a reservoir. Large-artery diameter was measured with piezoelectric crystals, and coronary flow was measured with an in-line electromagnetic flow probe. Intracoronary serotonin (5 and 50 micrograms/min) caused a dose-dependent constriction of the proximal LAD and increase in coronary flow. Intracoronary L-NMMA (2 mg/min) or L-NNA (2 mg/min) augmented the constriction to serotonin, whereas the increase in coronary flow was blunted only by L-NNA. L-Arg (10 mg/min, intracoronary) alone did not alter either the large-artery constriction or the increase in flow to serotonin; however, it prevented the enhanced constriction to serotonin following L-NMMA. Constriction to the endothelium-independent agent prostaglandin F2 alpha was not affected by L-NMMA. We conclude that a metabolite of L-Arg modulates the large coronary artery response to serotonin in vivo.
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41

Abele, Edgars, and Ramona Abele. "Oximes of Nucleosides and Related Compounds: Synthesis, Reactions and Biological Activity." Current Organic Synthesis 15, no. 5 (July 5, 2018): 650–65. http://dx.doi.org/10.2174/1570179415666180524112811.

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Background: Literature data on the synthesis and structure of oximes of nucleosides and related nitrogenous bases from pyrimidine and purine were reviewed. Synthesis of novel heterocyclic systems from nucleoside oximes related pyrimidine oximes was described. The biological activity of derivatives of nucleoside and nitrogenous base oximes was also reviewed. <p> Objective: The review focuses on the recent progress in the area of nucleoside oxime synthesis, reactions and biological activity. Conclusion: In summary, literature data on the synthesis and structure of oximes of nucleosides and related nitrogenous bases derived from pyrimidine, which play an important role in the biological processes, were reviewed. Synthesis of novel heterocyclic systems from nucleoside oximes related pyrimidine oximes was described. The biological activity of derivatives of nucleoside and nucleotide oximes was also reviewed. The studied class of compounds show a wide range of imino-amino and imino-nitroso tautomerism, which was investigated in the presented literature by 1H, 13C and 15N NMR spectroscopy methods. Also, according to the authors point of view, due to imino-amino and/or imino-nitroso tautomerism the nucleoside oximes show interesting activity. Most of the compounds exhibit biological activity characteristic of not only oxime derivatives, but also activity of hydroxylamines or nitroso compounds.
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42

Lv, Xue-Hui, Shuai-Liang Yang, Yuan-Xia Li, Chen-Xi Zhang, and Qing-Lun Wang. "A family of lanthanide compounds based on nitronyl nitroxide radicals: synthesis, structure, magnetic and fluorescence properties." RSC Advances 7, no. 61 (2017): 38179–86. http://dx.doi.org/10.1039/c7ra05764d.

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43

Sellmann, Dieter, and Michael Waeber. "Übergangsmetallkomplexe mit Schwefelliganden, XVIII. Synthese und Reaktionen von [Ru(L)(PPh3)dttd]-Komplexen mit kleinen Stickstoffverbindungen L = NH3, N2H4, N2H3CH3, N2H3C6H5 sowie NO+ (dttd2- = 2,3;8,9-Dibenzo-1,4,7,10-tetrathiadecan (–2))/ Transition Metal Complexes with Sulfur Ligands, XVIII. Synthesis and Reactions of [Ru(L)(PPh3)dttd] Complexes with Small Nitrogen Compounds L = NH3, N2H4, N2H3CH3, N2H3C6H5 and NO+ (dttd2- = 2,3;8,9-Dibenzo-1,4,7,10-tetrathiadecane (–2))." Zeitschrift für Naturforschung B 41, no. 7 (July 1, 1986): 877–84. http://dx.doi.org/10.1515/znb-1986-0714.

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Abstract Reaktionen von [Ru(L)(PPh3)dttd]-Komplexen mit kleinen Stickstoffverbindungen L = NH3, N2H4, N2H3CH3, N2H3C6H5 sowie NO+ (dttd2-= 2,3;8,9-Dibenzo-l,4,7,10-tetrathiadecan (—2)) Transition Metal Complexes with Sulfur Ligands, XVIII* Synthesis and Reactions of [R u(L)(PPh3)dttd] Complexes with Small Nitrogen Com pounds L = N H 3, N2H 4, N2H 3C H 3, N2H 3C6H 5 and N O + (dttd2-= 2,3;8,9-D ibenzo-l,4,7,10-tetrathiadecane (—2)) D ieter Sellmann+ Ruthenium Sulfur C om plexes, N itrogen Ligands The com plex fragment [Ru(PPh3)dttd], (dttd2-= 2,3;8,9-dibenzo-l,4,7,10-tetrath iad ecane (— 2)), coordinates small nitrogen com pounds, which have only o-as well as a-jr-donor proper­ ties. The reactions o f [Ru(PPh3)2dttd] with L — N H 3, N 2H 4, N 2H 3C H 3 and N 2H 3C6H 5, respec­ tively, give the corresponding [R u(L)(PP h3)dttd] com plexes. O xidation o f the hydrazine com ­ plex [R u(N 2H 4)(PPh3)dttd] yields [a-N 2H 2{R u(PP h3)dttd }2], the first diazene com plex in which the unstable N 2H 2 is bound to a sulfur coordinated m etal center and stabilized by a 4 c —6 e Ru— N — N — Ru system , steric shielding as well as thiolate — S---H (n,h2)---N hydrogen bridges. The reactions of the ammonia and the hydrazine com plexes, respectively, with N O PF6 yield the nitrosyl com plex [R u (N O)(PP h3)dttd]PF6 as final product; in the case o f [R u(N 2H 4)(P P h3)dttd] the intermediate formation of an azido com plex is observed IR -spectroscopically.
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44

Batchelor, Raymond J., Frederick W. B. Einstein, Nigel D. Lowe, Bradley A. Palm, Xiaoqian Yan, and Derek Sutton. "(Pentamethylcyclopentadienyl)nitrosyl(ethylene)iridium Tetrafluoroborate, [(.eta.5-C5Me5)Ir(NO)(C2H4)][BF4]: Synthesis, Characterization, and Some Reactions. X-ray Crystal Structures of the Title Compound and Its Derivatives (.eta.5-C5Me5)Ir(NO)(CH2CH2OEt) and (.eta.5-C5Me5)2Ir2X2(.mu.-X)(.mu.-NO) (X = Br, I)." Organometallics 13, no. 5 (May 1994): 2041–52. http://dx.doi.org/10.1021/om00017a070.

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45

Myers, P. R., T. F. Wright, M. A. Tanner, and H. R. Adams. "EDRF and nitric oxide production in cultured endothelial cells: direct inhibition by E. coli endotoxin." American Journal of Physiology-Heart and Circulatory Physiology 262, no. 3 (March 1, 1992): H710—H718. http://dx.doi.org/10.1152/ajpheart.1992.262.3.h710.

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Recent studies have yielded contradictory interpretations about the influence of gram-negative endotoxin on endothelium-derived relaxing factor (EDRF). We tested the hypothesis that Escherichia coli endotoxin exerts primary facilitatory or, alternatively, inhibitory actions on EDRF release and the synthesis of either nitric oxide or a nitroso compound in cultured endothelial cells. Bovine aortic endothelial cells were grown on microcarrier beads and either exposed acutely (30 min) to E. coli endotoxin or incubated with endotoxin for 1 h followed by a 1-h wash (prolonged exposure). EDRF bioactivity was measured under basal, bradykinin-stimulated, and A23187-stimulated conditions using standard isometric tension recordings. EDRF-derived nitric oxide was quantitated using a specific chemiluminescence technique. Endotoxin (0.005-5 micrograms/ml) decreased EDRF bioactivity and nitric oxide production under both basal and bradykinin-stimulated conditions after prolonged, but not acute, exposure. A23187-stimulated EDRF bioactivity and nitric oxide production were minimally, albeit significantly, reduced after endotoxin. The present results demonstrate that EDRF activity and nitric oxide production are decreased in vascular endothelial cells exposed to endotoxin. Endotoxin itself failed to directly stimulate EDRF release from endothelium. Alternative sources of nitrovasodilators, endothelium-independent effects, or release of other vasoactive mediators by endotoxin may be responsible for systemic hypotension during in vivo endotoxemia.
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46

Chen, Julie Y., Kevin R. Grundy, and Katherine N. Robertson. "Nitrosyl complexes of rhenium. 3. The synthesis and substitution reactions of [ReH(CH3OH)(NO)(PPh3)3]ClO4 derived from the reaction of ReH2(NO)(PPh3)3 with HClO4. Members of the series ReHX(NO)(PPh3)3." Canadian Journal of Chemistry 67, no. 7 (July 1, 1989): 1187–92. http://dx.doi.org/10.1139/v89-179.

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ReH2(NO)(PPh3)3 reacts with alcoholic HClO4 to yield the solvated cation, [ReH(ROH)(NO)(PPh3)3]ClO4 (R = CH3, C2H5) which can be isolated as an explosive solid (R = CH3 only). In the solid state, the perchlorate counter ion is hydrogen bound to the ligated alcohol, as observed for [ReH(CH3OH)(CO)(NO)(PPh3)2]ClO4. This latter complex also results from the reaction of [ReH(CH3OH)(NO)(PPh3)3]ClO4 with CO under ambient conditions. On reaction with p-tolylisocyanide (RNC), however, substitution is also accompanied by dihydrogen elimination to give [Re(OR)(NO)(CNR)2(PPh3)2]ClO4, irrespective of the mole ratio of the reactants. In contrast, [ReH(CH3OH)(NO)(PPh3)3]ClO4 reacts with coordinating anions with loss of methanol to give air-sensitive ReHX(NO)(PPh3)3 (X = OCH3, F, Cl, Br, I, N3, NCO, SCN), of which only those with X = Cl, Br, N3 were characterized in solution. The compounds ReHX(NO)(PPh3)3 are similar to their osmium analogues in having a labile third phosphine. Thus, reaction with neutral ligands such as CO or RNC leads to the series of neutral rhenium hydrido nitrosyls ReHX(L)(NO)(PPh3)2. Prior to this work, the only known examples from this series were those with L = CO, X = H, F, OCH3. Interestingly, the isomer of ReHF(CO)(NO)(PPh3)2 isolated in this work differs from that previously isolated (from the reaction of [ReF(CO)(NO)(PPh3)3]+ with [Formula: see text]) in having F trans to NO. All structural assignments have been made on the basis of elemental analyses, infrared spectroscopy, 1H and 31P nmr spectroscopy and deuteration studies, where appropriate. Keywords: hydrido, nytrosyl, rhenium, complexes.
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47

Nagaraju, Bashetti, Jagarlapudi V. Shanmukhakumar, Nareshvarma Seelam, Tondepu Subbaiah, and Bethanamudi Prasanna. "A Facile One-Pot Synthesis of 3-Methylbenzisoxazoles via a Key Intermediate of ortho-Ethoxyvinyl Nitroaryls by Domino Rearrangement and Their Anti- Inflammatory Activity." Current Organic Synthesis 16, no. 8 (January 20, 2020): 1161–65. http://dx.doi.org/10.2174/1570179416666190925125450.

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Background: Recently, there has been a lot of scientific interest in exploring the syntheses of oxygen and nitrogen-containing heterocyclic compounds due to their pharmacological activities. In addition, benzisoxazoles play a very important role in organic synthesis as key intermediates. Objective: In this paper, we focused on developing a novel synthetic route for biologically active arylisoxazoles under normal conditions, and simplified it to get high purities and yields, and also reported their anti-inflammatory activities. Method: An efficient and simple method has been explored for the synthesis of novel 3-methyl arylisoxazoles from o-nitroaryl halides via o-ethoxyvinylnitroaryls, using dihydrated stannous chloride (SnCl2.2H2O) in MeOH / EtOAc (1:1) via Domino rearrangement in one pot synthesis. Result: We synthesized novel 3-methylarylisoxazoles from o-nitroarylhalides via o-ethoxyvinylnitroaryls, using dihydrated stannous chloride (SnCl2.2H2O) in MeOH / EtOAc (1:1) via domino rearrangement. In this reduction, nitro group and ethoxy vinyl group change to the functional acyl ketones, followed by hetero cyclization. Here, the reaction proceeds without the isolation of intermediates like 2-acylnitroarenes and 2- acylanilines. All the synthesized compounds were completely characterized by the NMR and mass spectra. The compounds were also explored for their anti-inflammatory activity by carrageenan-induced inflammation in the albino rats (150-200 g) of either sex used in this entire study with the use of Diclofenac sodium as the standard drug. The initial evaluations identified leading targets with good to moderate anti-inflammatory activity. Conclusion: A simple, one-pot and convenient method has been explored for the synthesis of novel 3- methylarylisoxazoles with high purity and reaction yields. All the compounds 3a, 3c, 3d, 3f, 3g and 3h exhibited 51-64% anti-inflammatory activities.
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48

Sutter, Jean-Pascal, Myrtil L. Kahn, Stéphane Golhen, Lahcène Ouahab, and Olivier Kahn. "Synthesis and Magnetic Behavior of Rare-Earth Complexes with N,O-Chelating Nitronyl Nitroxide Triazole Ligands: Example of a [GdIII{Organic Radical}2] Compound with anS=9/2 Ground State." Chemistry - A European Journal 4, no. 4 (April 16, 1998): 571–76. http://dx.doi.org/10.1002/(sici)1521-3765(19980416)4:4<571::aid-chem571>3.0.co;2-g.

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49

Pozsgay, Vince, and Harold J. Jennings. "Azide synthesis with stable nitrosyl salts." Tetrahedron Letters 28, no. 43 (1987): 5091–92. http://dx.doi.org/10.1016/s0040-4039(00)95598-9.

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50

ESTRADA, Carmen, Carmen GÓMEZ, José MARTÍN-NIETO, Trinidad DE FRUTOS, Amparo JIMÉNEZ, and Antonio VILLALOBO. "Nitric oxide reversibly inhibits the epidermal growth factor receptor tyrosine kinase." Biochemical Journal 326, no. 2 (September 1, 1997): 369–76. http://dx.doi.org/10.1042/bj3260369.

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Although it has been demonstrated that NO inhibits the proliferation of different cell types, the mechanisms of its anti-mitotic action are not well understood. In this work we have studied the possible interaction of NO with the epidermal growth factor receptor (EGFR), using transfected fibroblasts which overexpress the human EGFR. The NO donors S-nitroso-N-acetylpenicillamine (SNAP), 1,1-diethyl-2-hydroxy-2-nitrosohydrazine (DEA-NO) and N-{4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl}propane-1,3-diamine (DETA-NO) inhibited DNA synthesis of fibroblasts growing in the presence of fetal calf serum, epidermal growth factor (EGF) or EGF plus insulin, as assessed by [methyl-3H]thymidine incorporation. Neither 8-bromo-cGMP nor the cGMP-phosphodiesterase inhibitor zaprinast mimicked this effect, suggesting that NO is unlikely to inhibit cell proliferation via a cGMP-dependent pathway. SNAP, DEA-NO and DETA-NO also inhibited the transphosphorylation of the EGFR and its tyrosine kinase activity toward the exogenous substrate poly-L-(Glu-Tyr), as measured in permeabilized cells using [γ-32P]ATP as phosphate donor. In contrast, 3-[morpholinosydnonimine hydrochloride] (SIN-1), a peroxynitrite-forming compound, did not significantly inhibit either DNA synthesis or the EGFR tyrosine kinase activity. The inhibitory action of DEA-NO on the EGFR tyrosine kinase was prevented by haemoglobin, an NO scavenger, but not by superoxide dismutase, and was reversed by dithiothreitol. The binding of EGF to its receptor was unaffected by DEA-NO. The inhibitory action of DEA-NO on the EGF-dependent transphosphorylation of the receptor was also demonstrated in intact cells by immunoblot analysis using an anti-phosphotyrosine antibody. Taken together, these results suggest that NO, but not peroxynitrite, inhibits in a reversible manner the EGFR tyrosine kinase activity by S-nitrosylation of the receptor.
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