Relevant bibliographies by topics / Synthesis of Allocolchicine

Academic literature on the topic 'Synthesis of Allocolchicine'

Author: Grafiati
Published: 6 September 2023

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Journal articles on the topic "Synthesis of Allocolchicine"

1

Fedorov, Alexey, Ekaterina Shchegravina, Elena Svirshchevskaya, and Hans-Günther Schmalz. "A Facile Synthetic Approach to Nonracemic Substituted Pyrrolo-allocolchicinoids Starting from Natural Colchicine." Synthesis 51, no. 07 (December 13, 2018): 1611–22. http://dx.doi.org/10.1055/s-0037-1610673.

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A six-step semisynthetic approach towards chiral nonracemic pyrrolo-allocolchicinoids starting from naturally occurring colchicine was developed. The synthetic scheme includes an electrocyclic tropolone ring contraction to afford allocolchicinic acid followed by the Curtius reaction, giving the corresponding aniline. The Sandmeyer reaction and copper-mediated hydrazination gave hydrazine-substituted allocolchicine. This was introduced into the Fischer indole synthesis, affording libraries of regioisomeric indole-based allocolchicine congeners.
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2

Sitnikov, Nikolay S., Alexander V. Sinzov, Diane Allegro, Pascale Barbier, Sebastien Combes, Liliane Abodo Onambele, Aram Prokop, Hans-Günther Schmalz, and Alexey Yu Fedorov. "Synthesis of indole-derived allocolchicine congeners exhibiting pronounced anti-proliferative and apoptosis-inducing properties." MedChemComm 6, no. 12 (2015): 2158–62. http://dx.doi.org/10.1039/c5md00320b.

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3

Djurdjevic, Sinisa, Fei Yang, and James R. Green. "Intramolecular Nicholas Reactions in the Synthesis of Dibenzocycloheptanes. Synthesis of Allocolchicine NSC 51046 and Analogues and the Formal Synthesis of (−)-Allocolchicine." Journal of Organic Chemistry 75, no. 23 (December 3, 2010): 8241–51. http://dx.doi.org/10.1021/jo101953n.

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4

Fedorov, Alexey, Iuliia Gracheva, Elena Svirshchevskaya, Vladimir Faerman, and Irina Beletskaya. "Synthesis and Antiproliferative Properties of Bifunctional Allocolchicine Derivatives." Synthesis 50, no. 14 (May 28, 2018): 2753–60. http://dx.doi.org/10.1055/s-0037-1610146.

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Based on the natural antimitotic agent colchifoline as a lead structure, a series of novel bifunctional allocolchicine congeners were synthesized from commercial colchicine. The new derivatives maintain good cytotoxicity against T3M4, MiaPaCa-2, and PANC-1 cell lines. The presence of functional groups simplifies further modifications of the prepared structures and the design of novel colchicine-derived antitumor compounds with desired pharmacological properties.
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5

Zotov, A. S., E. S. Shchegravina, and A. Yu Fedorov. "Synthesis of Allocolchicine Conjugates with a Cetirizine Analog." Russian Journal of Organic Chemistry 54, no. 10 (October 2018): 1498–504. http://dx.doi.org/10.1134/s107042801810010x.

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6

Banwell, MG, JM Cameron, M. Corbett, JR Dupuche, E. Hamel, JN Lambert, CM Lin, and MF Mackay. "Synthesis and Tubulin-Binding Properties of Some AC- and ABC-Ring Analogs of Allocolchicine." Australian Journal of Chemistry 45, no. 12 (1992): 1967. http://dx.doi.org/10.1071/ch9921967.

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Fourteen analogues [compounds (8), (9) and (11)-(22)] of the powerful antimitotic agent allocolchicine (5) have been prepared and evaluated for their ability to prevent tubulin polymerization. The X-ray structure of one of the more active compounds, tricycle (20), is reported.
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7

Djurdjevic, Sinisa, Fei Yang, and James R. Green. "ChemInform Abstract: Intramolecular Nicholas Reactions in the Synthesis of Dibenzocycloheptanes. Synthesis of Allocolchicine NSC 51046 (IVa) and Analogues and the Formal Synthesis of (-)-Allocolchicine (V)." ChemInform 42, no. 11 (February 17, 2011): no. http://dx.doi.org/10.1002/chin.201111108.

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8

Joncour, Agnès, Anne Décor, Jian-Miao Liu, Marie-Elise Tran Huu Dau, and Olivier Baudoin. "Asymmetric Synthesis of Antimicrotubule Biaryl Hybrids of Allocolchicine and Steganacin." Chemistry - A European Journal 13, no. 19 (June 25, 2007): 5450–65. http://dx.doi.org/10.1002/chem.200601764.

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9

Krasniqi, Besir, and Wim Dehaen. "Synthesis of 1,2,3-Triazolo-Fused Allocolchicine Analogs via Intramolecular Oxidative Biaryl Coupling." Organic Letters 21, no. 13 (June 26, 2019): 5002–5. http://dx.doi.org/10.1021/acs.orglett.9b01707.

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10

Sitnikov, Nikolay, Janna Velder, Liliane Abodo, Nicole Cuvelier, Jörg Neudörfl, Aram Prokop, Günter Krause, Aleksey Y. Fedorov, and Hans-Günther Schmalz. "Total Synthesis of Indole-Derived Allocolchicine Analogues Exhibiting Strong Apoptosis-Inducing Activity." Chemistry - A European Journal 18, no. 38 (August 27, 2012): 12096–102. http://dx.doi.org/10.1002/chem.201200083.

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Dissertations / Theses on the topic "Synthesis of Allocolchicine"

1

Seganish, William Michael. "Development of aryl siloxane cross-coupling technology and its application to the synthesis of colchicine and allocolchicine derivatives." College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/3063.

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Thesis (Ph. D.)--University of Maryland, College Park, 2005.
Thesis research directed by: Chemistry. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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2

Vorogushin, Andrei Vladimirovich. "Regio- and stereoselective approach to allocolchicinoids : benzannulation and Diels-Alder reactions, total synthesis of ( - )-allocolchicine /." 2003. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3097169.

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