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Journal articles on the topic 'Synthesis Novel Bioactive Steroids'

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Author: Grafiati

Published: 6 September 2023

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1

Silva, Gabriela A., Olga P. Coutinho, Paul Ducheyne, I. M. Shapiro, and Rui L. Reis. "Starch-Based Microparticles as a Novel Strategy for Tissue Engineering Applications." Key Engineering Materials 309-311 (May 2006): 907–10. http://dx.doi.org/10.4028/www.scientific.net/kem.309-311.907.

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Current tissue engineering strategies involve the use of scaffold materials with properties specific for the target tissue. When the tissue being treated is bone, properties such as bone bonding behaviour and excellent biological performance are very desirable. Many strategies involve the creation in vitro of a suitable hybrid construct (i.e., comprising a scaffold material and cells). These scaffolds are then inserted into the defect site, thus achieving faster integration and hence, repair. Herein, we describe the synthesis and characterization of starch-based microparticles for bone tissue engineering. This study describes the properties of two types of starch-based microparticles: their bioactivity in vitro (when processed with Bioactive Glass 45S5), the good biological performance and also the ability to be used as controlled release vehicles of bioactive molecules, such as steroids and growth factors.

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2

Berger, Andreas, Georg Petschenka, Thomas Degenkolb, Michael Geisthardt, and Andreas Vilcinskas. "Insect Collections as an Untapped Source of Bioactive Compounds—Fireflies (Coleoptera: Lampyridae) and Cardiotonic Steroids as a Proof of Concept." Insects 12, no. 8 (July 31, 2021): 689. http://dx.doi.org/10.3390/insects12080689.

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Natural history collections provide an invaluable basis for systematics, ecology, and conservation. Besides being an important source of DNA, museum specimens may also contain a plethora of natural products. Especially, dried insect collections represent a global repository with billions of inventoried vouchers. Due to their vast diversity, insects possess a great variety of defensive compounds, which they either produce autogenously or derive from the environment. Here, we present a case study on fireflies (Coleoptera: Lampyridae), which produce bufadienolides as a defense against predators. These toxins belong to the cardiotonic steroids, which are used for the treatment of cardiac diseases and specifically inhibit the animal enzyme Na+/K+-ATPase. Bufadienolides have been reported from only seven out of approximately 2000 described firefly species. Using a non-destructive approach, we screened 72 dry coleopteran specimens for bufadienolides using HPLC-DAD and HPLC-MS. We found bufadienolides including five novel compounds in 21 species of the subfamily Lampyrinae. The absence of bufadienolides in the phylogenetically related net-winged beetles (Lycidae) and the lampyrid subfamilies Luciolinae and Lamprohizinae indicates a phylogenetic pattern of bufadienolide synthesis. Our results emphasize the value of natural history collections as an archive of chemical information for ecological and evolutionary basic research and as an untapped source for novel bioactive compounds.

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3

Larayetan, Rotimi, Zacchaeus S. Ololade, Oluranti O. Ogunmola, and Ayodele Ladokun. "Phytochemical Constituents, Antioxidant, Cytotoxicity, Antimicrobial, Antitrypanosomal, and Antimalarial Potentials of the Crude Extracts of Callistemon citrinus." Evidence-Based Complementary and Alternative Medicine 2019 (August 28, 2019): 1–14. http://dx.doi.org/10.1155/2019/5410923.

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Plants are reservoir for potentially useful bioactive compounds, and owing to the rising occurrences of drug resistance to malaria parasites, there is a need to discover and develop new phytochemicals in plant that can be used as antimalarial agents. In this study, we gave a detailed description of the phytochemicals present in both ethyl acetate and methanolic extracts of Callistemon citrinus (C. citrinus) using Gas Chromatography-Mass Spectrometry (GC-MS) analysis; both extracts were also evaluated for their in vitro antimalarial, antitrypanosomal, and cytotoxicity activities against Trypanosoma brucei brucei (T. b brucei) parasites, Plasmodium falciparum (P. falciparum) malaria parasites 3D7 strain, and human cervix adenocarcinoma cells (HeLa cells); in addition, the antimicrobial and antioxidant efficacies were determined using standard methods. Both extracts were characterized by a high amount of fatty acids (52.88 and 62.48%). The ethyl acetate extract exhibited a greater activity with minimum inhibitory concentration (MIC) values ranging from 0.025 to 0.10 mg/mL while the methanol extract ranged from 0.025 to 0.15 mg/mL. Both extracts were bactericidal to Escherichia coli ATCC 35150 (E. coli) and Pseudomonas aeruginosa ACC (P. aeruginosa). Qualitative and quantitative phytochemical screenings conducted for both extracts revealed the presence of alkaloids, glycosides, saponins, steroids, and triterpenoids, fat and oils, flavonoids, phenols, and tannins in varying amounts. Both crude extracts exhibited antitrypanosomal potentials with an IC50 of 6.6/9.7 μg/mL and antiplasmodial activities with an IC50 of 8.4/13.0 μg/mL. Conclusion from this study indicates that apart from the folkloric uses of this plant in traditional settings, the extracts possess a broad spectrum of antimicrobial, antitrypanosomal, and antimalarial activities and some pharmaceutically essential bioactive components with remarkable antioxidant capacities that may be used in the synthesis of novel drugs for the management of different varieties of ailments.

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4

Singh, Meenakshi, V. Ravichandiran, Yogesh P. Bharitkar, and Abhijit Hazra. "Natural Products Containing Olefinic Bond: Important Substrates for Semi-synthetic Modification Towards Value Addition." Current Organic Chemistry 24, no. 7 (June 3, 2020): 709–45. http://dx.doi.org/10.2174/1385272824666200312125734.

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: Semi-synthesis, the way of preparing novel bioactive molecules via modification of compounds isolated from natural sources is very much useful nowadays in the drug discovery process. The modification is based on the reaction of functional group(s) present in a natural compound. Among the examples of functional group transformation, double bond modification is also common in the literature. Several reactions like hydrogenation, cyclopropanation, epoxidation, addition reaction (halogenations, hydroxylation), Michael addition, Heck reaction, cycloaddition, dipolar cycloaddition, etc. are employed for this purpose. In this review, we have tried to gather the reactions performed with several double bond containing classes of natural products like diterpenes, xanthones, sesquiterpene exomethylene lactones, diaryl heptanoids, steroidal lactones, triterpenoids, limonoids, and alkamides. Where available, the effects of transformations on the biological activities of the molecules are also mentioned.

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5

Srivastava, Shubhi, and Paul A. K. "Associated microflora of medicinal ferns: biotechnological potentials and possible applications." International Journal of Bioassays 5, no. 03 (February 29, 2016): 4927. http://dx.doi.org/10.21746/ijbio.2016.03.0017.

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Plant associated microorganisms that colonize the upper and internal tissues of roots, stems, leaves and flowers of healthy plants without causing any visible harmful or negative effect on their host. Diversity of microbes have been extensively studied in a wide variety of vascular plants and shown to promote plant establishment, growth and development and impart resistance against pathogenic infections. Ferns and their associated microbes have also attracted the attention of the scientific communities as sources of novel bioactive secondary metabolites. The ferns and fern alleles, which are well adapted to diverse environmental conditions, produce various secondary metabolites such as flavonoids, steroids, alkaloids, phenols, triterpenoid compounds, variety of amino acids and fatty acids along with some unique metabolites as adaptive features and are traditionally used for human health and medicine. In this review attention has been focused to prepare a comprehensive account of ethnomedicinal properties of some common ferns and fern alleles. Association of bacteria and fungi in the rhizosphere, phyllosphere and endosphere of these medicinally important ferns and their interaction with the host plant has been emphasized keeping in view their possible biotechnological potentials and applications. The processes of host-microbe interaction leading to establishment and colonization of endophytes are less-well characterized in comparison to rhizospheric and phyllospheric microflora. However, the endophytes are possessing same characteristics as rhizospheric and phyllospheric to stimulate the in vivo synthesis as well as in vitro production of secondary metabolites with a wide range of biological activities such as plant growth promotion by production of phytohormones, siderophores, fixation of nitrogen, and phosphate solubilization. Synthesis of pharmaceutically important products such as anticancer compounds, antioxidants, antimicrobials, antiviral substances and hydrolytic enzymes could be some of the promising areas of research and commercial exploitation.

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6

Seferovic, Maxim D., Christine A. Beamish, Rockann E. Mosser, Shannon E. Townsend, Kirk Pappan, Vincent Poitout, Kjersti M. Aagaard, and Maureen Gannon. "Increases in bioactive lipids accompany early metabolic changes associated with β-cell expansion in response to short-term high-fat diet." American Journal of Physiology-Endocrinology and Metabolism 315, no. 6 (December 1, 2018): E1251—E1263. http://dx.doi.org/10.1152/ajpendo.00001.2018.

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Pancreatic β-cell expansion is a highly regulated metabolic adaptation to increased somatic demands, including obesity and pregnancy; adult β cells otherwise rarely proliferate. We previously showed that high-fat diet (HFD) feeding induces mouse β-cell proliferation in less than 1 wk in the absence of insulin resistance. Here we metabolically profiled tissues from a short-term HFD β-cell expansion mouse model to identify pathways and metabolite changes associated with β-cell proliferation. Mice fed HFD vs. chow diet (CD) showed a 14.3% increase in body weight after 7 days; β-cell proliferation increased 1.75-fold without insulin resistance. Plasma from 1-wk HFD-fed mice induced β-cell proliferation ex vivo. The plasma, as well as liver, skeletal muscle, and bone, were assessed by LC and GC mass-spectrometry for global metabolite changes. Of the 1,283 metabolites detected, 159 showed significant changes [false discovery rate (FDR) < 0.1]. The majority of changes were in liver and muscle. Pathway enrichment analysis revealed key metabolic changes in steroid synthesis and lipid metabolism, including free fatty acids and other bioactive lipids. Other important enrichments included changes in the citric acid cycle and 1-carbon metabolism pathways implicated in DNA methylation. Although the minority of changes were observed in bone and plasma (<20), increased p-cresol sulfate was increased >4 fold in plasma (the largest increase in all tissues), and pantothenate (vitamin B5) decreased >2-fold. The results suggest that HFD-mediated β-cell expansion is associated with complex, global metabolite changes. The finding could be a significant insight into Type 2 diabetes pathogenesis and potential novel drug targets.

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7

Yuvaraj, S., Monica Mendon, Asha Almeida, Mini Dhiman, and Manju Girish. "Synthesis of novel bioactive pyrazolothiazoles." Medicinal Chemistry Research 23, no. 5 (October 31, 2013): 2667–75. http://dx.doi.org/10.1007/s00044-013-0825-8.

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8

Wang, Zhuo, and Chunngai Hui. "Contemporary advancements in the semi-synthesis of bioactive terpenoids and steroids." Organic & Biomolecular Chemistry 19, no. 17 (2021): 3791–812. http://dx.doi.org/10.1039/d1ob00448d.

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9

Litvinovskaya, R. P., S. V. Drach, M. E. Raiman, and V. A. Khripach. "Novel synthesis of 2-isoxazolyl steroids." Chemistry of Heterocyclic Compounds 43, no. 5 (May 2007): 637–39. http://dx.doi.org/10.1007/s10593-007-0099-5.

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10

Seo, Youngwan, Jee H. Jung, Jung-Rae Rho, Jongheon Shin, and Jun-Im Song. "Isolation of novel bioactive steroids from the soft coral Alcyonium gracillimum." Tetrahedron 51, no. 9 (February 1995): 2497–506. http://dx.doi.org/10.1016/0040-4020(95)00014-y.

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11

Silva, G. A., F. J. Costa, O. P. Coutinho, S. Radin, P. Ducheyne, and R. L. Reis. "Synthesis and evaluation of novel bioactive composite starch/bioactive glass microparticles." Journal of Biomedical Materials Research 70A, no. 3 (2004): 442–49. http://dx.doi.org/10.1002/jbm.a.30099.

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12

Khokhani, Kamlesh, Taslimahemad Khatri, and Praful Patel. "One Pot Synthesis of Bioactive Novel Cyanopyridones." Journal of the Korean Chemical Society 57, no. 4 (August 20, 2013): 476–82. http://dx.doi.org/10.5012/jkcs.2013.57.4.476.

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13

Ghani, Ambreen, Erum A. Hussain, Abida Yasmeen, Narjis Naz, and Shaheen Asghar. "Synthesis of Novel 2,4-Disubstituted Bioactive Thiazoles." Asian Journal of Chemistry 26, Supp. (2014): S211—S213. http://dx.doi.org/10.14233/ajchem.2014.19049.

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14

Drew, Michael G. B., John Mann, and Barbara Pietrzak. "Synthesis of 19,19-difuoro steroids and of novel B-ring-expanded steroids." Journal of the Chemical Society, Chemical Communications, no. 17 (1985): 1191. http://dx.doi.org/10.1039/c39850001191.

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15

Lan-Hargest, Hsuan-Yin, John D. Elliott, Drake S. Eggleston, Dennis A. Holt, Mark A. Levy, and Brian W. Metcalf. "The synthesis of novel bridged a ring steroids." Tetrahedron Letters 28, no. 49 (January 1987): 6117–20. http://dx.doi.org/10.1016/s0040-4039(00)61823-3.

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16

Skoda-Földes, Rita, György Jeges, László Kollár, Judit Horváth, and Zoltán Tuba. "Facile, high-yielding synthesis of novel pentacyclic steroids." Tetrahedron Letters 37, no. 12 (March 1996): 2085–88. http://dx.doi.org/10.1016/0040-4039(96)00199-2.

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17

Sunazuka, Toshiaki, Tomoyasu Hirose, and Satoshi O̅mura. "Efficient Total Synthesis of Novel Bioactive Microbial Metabolites." Accounts of Chemical Research 41, no. 2 (February 2008): 302–14. http://dx.doi.org/10.1021/ar6000044.

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18

Klein, Larry L. "Synthesis of 9-dihydrotaxol: A novel bioactive taxane." Tetrahedron Letters 34, no. 13 (March 1993): 2047–50. http://dx.doi.org/10.1016/s0040-4039(00)60342-8.

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19

Watanabe, Takumi, Tomio Takeuchi, Shiho Kohzuma, Kazuo Umezawa, and Masami Otsuka. "Total synthesis of (±)-aglaiastatin, a novel bioactive alkaloid." Chemical Communications, no. 10 (1998): 1097–98. http://dx.doi.org/10.1039/a801502c.

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20

Angelopoulou, A., E. Κ. Efthimiadou, and G. Kordas. "Synthesis of novel quaternary silica hybrid bioactive microspheres." Journal of Biomedical Materials Research Part B: Applied Biomaterials 106, no. 1 (November 25, 2016): 112–20. http://dx.doi.org/10.1002/jbm.b.33817.

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21

Sampath, VishnuPriya, Noa Horesh, Ben Sasi, Hiba Zannadeh, Ilana Pogodin, Shiv Vardan Singh, Joseph Deutsch, and David Lichtstein. "Synthesis and Biological Evaluation of Novel Bufalin Derivatives." International Journal of Molecular Sciences 23, no. 7 (April 4, 2022): 4007. http://dx.doi.org/10.3390/ijms23074007.

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Bufalin and other cardiac steroids (CS) have been used for centuries for the treatment of congestive heart failure, arrhythmias, and other maladies. However, toxicity and the small therapeutic window of this family of steroids limit their use. Therefore, attempts to synthesize a potent, but less toxic, CS are of major importance. In the present study, two novel bufalin derivatives were synthesized and some of their pharmacological properties were characterized. The reaction of bufalin with Ishikawa’s reagent resulted in the production of two novel bufalin derivatives: bufalin 2,3-ene and bufalin 3,4-ene. The compounds were purified with TLC and HPLC and their structure was verified with UV, NMR, and MS analyses. The biological activities of these compounds were evaluated by testing their ability to inhibit the Na+, K+-ATPase activity of the brain microsomal fraction to induce cytotoxic activity against the NCI-60 human tumor cell line panel and non-cancer human cells, and to increase the force of contraction of quail embryonic heart muscle cells in culture. The two steroids exhibited biological activities similar to those of other CS in the tested experimental systems, but with reduced cytotoxicity, advocating their development as drugs for the treatment of heart failure and arrhythmias.

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22

Nickisch, Klaus, Hareesh B. Nair, Narkunan Kesavaram, Baishakhi Das, Robert Garfield, Shao-Qing Shi, Shylesh S. Bhaskaran, Sandra L. Grimm, and Dean P. Edwards. "Synthesis and antiprogestational properties of novel 17-fluorinated steroids." Steroids 78, no. 9 (September 2013): 909–19. http://dx.doi.org/10.1016/j.steroids.2013.04.003.

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23

Andryushina, V. A., N. V. Karpova, A. V. Druzhinina, T. S. Stytsenko, E. A. Podorozhko, A. N. Ryabev, and V. I. Lozinsky. "Novel immobilized biocatalyst for microbiological synthesis of pharmaceutical steroids." Applied Biochemistry and Microbiology 51, no. 5 (August 30, 2015): 530–38. http://dx.doi.org/10.1134/s0003683815050026.

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24

Dahibhate, Nilesh Lakshman, Ankush Ashok Saddhe, and Kundan Kumar. "Mangrove Plants as a Source of Bioactive Compounds: A Review." Natural Products Journal 9, no. 2 (March 18, 2019): 86–97. http://dx.doi.org/10.2174/2210315508666180910125328.

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Mangroves are unique coastal forest ecosystem distributed along the tropical and subtropical region of the world. They are evolutionarily adapted to combat against hostile environmental conditions such as low oxygen, high salinity, and temperature. The adaptive features endowed with novel secondary metabolic pathways and bioactive compounds to sustain in harsh conditions. The novel metabolites are a rich source of the wide range of bioactive compounds and natural products. It includes terpenoids, alkaloids, phenolics, saponins, flavonoids, and steroids. The bioactive and natural compounds may serve as therapeutic precursors and industrial raw materials. Terpenes and polyphenols have antiviral, antibacterial, antifungal, antimalarial, anticancer or combination of activities. To date, several mangroves plants were examined and recognized as a potential source of novel natural product for exploitation in medicine. In fact, most of the isolated compounds are novel and showed promising biological activities such as gastroprotective, cytotoxic, antioxidant, antibacterial, antifungal, antiviral, enzyme activation and inhibition, immunosuppressive, anti-inflammatory, antifeedant effects. In the present review, we have compiled the achievements and progress in mangroves natural products research of the last decade.

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25

Cherkasov, Rafael A., Narkis G. Khusainova, Eugeny A. Berdnikov, Mikhail A. Khusainov, and Sergey M. Rybakov. "Synthesis of Novel Bis(aminoalkenylphosphonates) as Potential Bioactive Compounds." Phosphorus, Sulfur, and Silicon and the Related Elements 186, no. 4 (March 31, 2011): 972–73. http://dx.doi.org/10.1080/10426507.2010.506666.

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26

Freidinger, Roger M. "Design and Synthesis of Novel Bioactive Peptides and Peptidomimetics." Journal of Medicinal Chemistry 46, no. 26 (December 2003): 5553–66. http://dx.doi.org/10.1021/jm030484k.

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27

Erturk, Aliye Gediz. "Synthesis, structural identifications of bioactive two novel Schiff bases." Journal of Molecular Structure 1202 (February 2020): 127299. http://dx.doi.org/10.1016/j.molstruc.2019.127299.

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28

Karataş, Semra, İrfan Çapan, and Süleyman Servi. "Synthesis of Indole and Benzimidazole Substituted Novel 16-Arylidene Steroid Derivatives." Letters in Organic Chemistry 16, no. 11 (October 2, 2019): 884–90. http://dx.doi.org/10.2174/1570178616666190305130217.

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Novel aza-heterocyclic substituted dehydroepiandrosterone derivatives were synthesized through a three-step reaction sequence. Some new O-alkylated 4-hydroxybenzaldehydes were synthesized from the reaction of substituted benzaldehydes with dihalogen compounds which have different chain lengths. 16-Arylidene steroids were synthesized from the base-catalyzed aldol condensation of O-alkylated 4-hydroxybenzaldehydes and dehydroepiandrosterone. New indolyl and benzimidazolyl substituted steroid derivatives as hybrid molecules were obtained from the reaction of 16-arylidene steroids with indole or benzimidazole.

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29

Manganyi, Madira Coutlyne, and Collins Njie Ateba. "Untapped Potentials of Endophytic Fungi: A Review of Novel Bioactive Compounds with Biological Applications." Microorganisms 8, no. 12 (December 6, 2020): 1934. http://dx.doi.org/10.3390/microorganisms8121934.

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Over the last century, endophytic fungi have gained tremendous attention due to their ability to produce novel bioactive compounds exhibiting varied biological properties and are, therefore, utilized for medicinal, pharmaceutical, and agricultural applications. Endophytic fungi reside within the plant tissues without showing any disease symptoms, thus supporting the physiological and ecological attributes of the host plant. Ground breaking lead compounds, such as paclitaxel and penicillin, produced by endophytic fungi have paved the way for exploring novel bioactive compounds for commercial usage. Despite this, limited research has been conducted in this valuable and unique niche area. These bioactive compounds belong to various structural groups, including alkaloids, peptides, steroids, terpenoids, phenols, quinones, phenols, and flavonoids. The current review focuses on the significance of endophytic fungi in producing novel bioactive compounds possessing a variety of biological properties that include antibacterial, antiviral, antifungal, antiprotozoal, antiparasitic, antioxidant, immunosuppressant, and anticancer functions. Taking into consideration the portal of this publication, special emphasis is placed on the antimicrobial and antiviral activities of metabolites produced by endophytes against human pathogens. It also highlights the importance of utilization of these compounds as potential treatment agents for serious life-threatening infectious diseases. This is supported by the fact that several findings have indicated that these bioactive compounds may significantly contribute towards the fight against resistant human and plant pathogens, thus motivating the need enhance the search for new, more efficacious and cost-effective antimicrobial drugs.

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30

Limbadri, Salendra, Xiaowei Luo, Xiuping Lin, Shengrong Liao, Junfeng Wang, Xuefeng Zhou, Bin Yang, and Yonghong Liu. "Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012." Molecules 23, no. 9 (September 18, 2018): 2379. http://dx.doi.org/10.3390/molecules23092379.

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Two new alkaloids, fumigatosides E (1) and F (2), and a new natural product, 3, 7-diketo-cephalosporin P1 (6) along with five known compounds (3–5, 7, 8) were isolated from deep-sea derived fungal Aspergillus fumigatus SCSIO 41012. Their structures were determined by extensive spectroscopic data analysis, including 1D, 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS), and comparison between the calculated and experimental electronic circular dichroism (ECD) spectra. In addition, all compounds were tested for antibacterial and antifungal inhibitory activities. Compound 1 showed significant antifungal activity against Fusarium oxysporum f. sp. momordicae with MIC at 1.56 µg/mL. Compound 4 exhibited significant higher activity against S. aureus (16,339 and 29,213) with MIC values of 1.56 and 0.78 µg/mL, respectively, and compound 2 exhibited significant activity against A. baumanii ATCC 19606 with a MIC value of 6.25 µg/mL.

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31

Ortega, Humberto, Daniel Torres-Mendoza, Zuleima Caballero E., and Luis Cubilla-Rios. "Structurally Uncommon Secondary Metabolites Derived from Endophytic Fungi." Journal of Fungi 7, no. 7 (July 17, 2021): 570. http://dx.doi.org/10.3390/jof7070570.

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Among microorganisms, endophytic fungi are the least studied, but they have attracted attention due to their high biological diversity and ability to produce novel and bioactive secondary metabolites to protect their host plant against biotic and abiotic stress. These compounds belong to different structural classes, such as alkaloids, peptides, terpenoids, polyketides, and steroids, which could present significant biological activities that are useful for pharmacological or medical applications. Recent reviews on endophytic fungi have mainly focused on the production of novel bioactive compounds. Here, we focus on compounds produced by endophytic fungi, reported with uncommon bioactive structures, establishing the neighbor net and diversity of endophytic fungi. The review includes compounds published from January 2015 to December 2020 that were catalogued as unprecedented, rare, uncommon, or possessing novel structural skeletons from more than 39 different genera, with Aspergillus and Penicillium being the most mentioned. They were reported as displaying cytotoxic, antitumor, antimicrobial, antiviral, or anti-inflammatory activity. The solid culture, using rice as a carbon source, was the most common medium utilized in the fermentation process when this type of compound was isolated.

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32

El-Kady, Dina S., Ahmed A. Abd Rabou, Mohamed A. Tantawy, Adel A. H. Abdel-Rahman, Amira A. S. Abdel-Megeed, Mervat M. AbdElhalim, and Gamal A. Elmegeed. "Synthesis and Evaluation of Novel Cholestanoheterocyclic Steroids as Anticancer Agents." Applied Biochemistry and Biotechnology 188, no. 3 (January 6, 2019): 635–62. http://dx.doi.org/10.1007/s12010-018-02943-6.

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33

Jin, Chunyang, Scott E. Fix, John A. Kepler, and C. Edgar Cook. "Synthesis and antihormonal properties of novel 11β-benzoxazole-substituted steroids." Bioorganic & Medicinal Chemistry Letters 22, no. 4 (February 2012): 1705–8. http://dx.doi.org/10.1016/j.bmcl.2011.12.110.

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34

Mosley, Robert J., Matthew V. Talarico, and Mark E. Byrne. "Recent applications of QCM-D for the design, synthesis, and characterization of bioactive materials." Journal of Bioactive and Compatible Polymers 36, no. 4 (May 21, 2021): 261–75. http://dx.doi.org/10.1177/08839115211014216.

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The clinical translation of bioactive technologies is lacking compared to the number of novel technologies reported in the literature. This is in part due to the difficulties in characterizing bioactive materials to understand and predict their biological response. To progress the field and increase clinical success, more robust analytical techniques must be utilized when investigating novel bioactive materials. The quartz crystal microbalance with dissipation (QCM-D), a label-free sensing instrument based on an acoustic resonator, is used to quantify mass change and viscoelastic parameters from soft materials at the nanoscale, in situ, with precise temporal resolution and operation in both liquid and gaseous environments. The versatility of QCM-D has enhanced the characterization of bioactive polymers and sensing arrays for advanced applications of novel biotechnologies. In this review, we highlight exciting, recent applications of QCM-D for the investigation of bioactive materials. Attention is given to the dynamic mechanical properties of bioactive materials, discerning protein structure on surfaces, probing cell adhesion and cytoskeletal changes, and biosensing applications. We conclude that QCM-D has untapped utility in the pre-clinical investigation of bioactive materials and further utilization can improve the clinical success of novel technologies.

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35

Han, Liwen, Wenlong Sheng, Xiaobin Li, Attila Sik, Houwen Lin, Kechun Liu, and Lizhen Wang. "Novel carbohydrate modified berberine derivatives: synthesis andin vitroanti-diabetic investigation." MedChemComm 10, no. 4 (2019): 598–605. http://dx.doi.org/10.1039/c9md00036d.

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36

Sunazuka, Toshiaki, and Satoshi Ōmura. "Total Synthesis of α-Pyrone Meroterpenoids, Novel Bioactive Microbial Metabolites." Chemical Reviews 105, no. 12 (December 2005): 4559–80. http://dx.doi.org/10.1021/cr040628i.

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37

Damu, Guri L. V., Sheng-Feng Cui, Xin-Mei Peng, Qin-Mei Wen, Gui-Xin Cai, and Cheng-He Zhou. "Synthesis and bioactive evaluation of a novel series of coumarinazoles." Bioorganic & Medicinal Chemistry Letters 24, no. 15 (August 2014): 3605–8. http://dx.doi.org/10.1016/j.bmcl.2014.05.029.

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38

WATANABE, T., S. KOHZUMA, T. TAKEUCHI, M. OTSUKA, and K. UMEZAWA. "ChemInform Abstract: Total Synthesis of (.+-.)-Aglaiastatin, a Novel Bioactive Alkaloid." ChemInform 29, no. 38 (June 19, 2010): no. http://dx.doi.org/10.1002/chin.199838252.

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Kang, Fu-An, George Allan, Jihua Guan, Nareshkumar Jain, Olivia Linton, Pamela Tannenbaum, Jun Xu, et al. "Synthesis and identification of novel oxa-steroids as progesterone receptor antagonists." Bioorganic & Medicinal Chemistry Letters 17, no. 4 (February 2007): 907–10. http://dx.doi.org/10.1016/j.bmcl.2006.11.062.

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JINDAL, D. P., R. GUPTA, R. KAUSHAL, I. B. SINGH, and M. R. YADAV. "ChemInform Abstract: Synthesis of Some Novel Heterocyclic Steroids by Beckmann Rearrangement." ChemInform 27, no. 43 (August 4, 2010): no. http://dx.doi.org/10.1002/chin.199643177.

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Mubarak Muhammad Dahiru, Enoch Buba Badgal, and Neksumi Musa. "Phytochemistry, GS-MS analysis, and heavy metals composition of aqueous and ethanol stem bark extracts of Ximenia americana." GSC Biological and Pharmaceutical Sciences 21, no. 3 (December 30, 2022): 145–56. http://dx.doi.org/10.30574/gscbps.2022.21.3.0462.

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Medicinal plants employed in the management of diseases has been attributed to their phytochemical compositions. The present study aimed to investigate the phytochemicals, bioactive, and heavy metals components present in aqueous and ethanol stem bark extracts of Ximenia americana. The phytochemical compositions were qualitatively, and quantitatively determined, followed by the identification of bioactive compounds present. The heavy metals composition was also determined. The result revealed the presence of saponins in the aqueous (30.67% ±0.39), and ethanol (19.67% ±0.78) extract. However, alkaloids (14.61% ±0.46) were detected only in the aqueous extract while steroids (7.00% ±1.16), and glycosides (0.38% ±0.03) were in the ethanol extract only. A total of 17 and 26 compounds were identified in the aqueous and ethanol extract respectively. Chromium and lead had a concentration of 0.184 ppm ±0.080 and 0.886 ppm ±0.210 respectively in the aqueous and ethanol extract. Cadmium had a concentration of 0.001 ppm ±0.000 in both aqueous and ethanol extract. Conclusively, X. americana contains bioactive components that could be utilized in the production of novel drugs by isolation of these bioactive compounds.

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R, Gobalakrishnan, and Bhuvaneswari R. "Natural bioactive compounds and antimicrobial potential of Pavetta indica L." Journal of Analytical & Pharmaceutical Research 10, no. 4 (August 27, 2021): 161–64. http://dx.doi.org/10.15406/japlr.2021.10.00381.

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Terrestrial plants have opened up a new perspective for pharmaceutical research and development of novel antimicrobial agents for the treatment of microbial diseases. Therefore, it is necessary to start an urgent need to screen the plants for novel bioactive compounds. In this context, present study was carried out to screen phytochemical constituents from leaves of Pavetta indica L., and its antimicrobial potential. P. indica leaves possess Chlorophyll a (1.21 ±0.05 mg g-1), Chlorophyll b (1.61 ±0.09 mg g-1), total chlorophyll (2.82 ±0.13 mg g-1), carotenoids (0.57 ±0.06 mg g-1), total soluble sugars (30.08 ±0.79 mg g-1), total soluble starch (13.54 ± 0.72), total soluble proteins (47.81 ± 2.82 mg g-1), total free amino acids (5.77 ± 0.69 mg g-1), total phenol (7.67 ± 0.72 mg g-1), hydroxyl phenols (5.74 ± 0.29 mg g-1) and lipids (53.53 ± 2.50 mg g-1) while alkaloids, tannins, steroids, phenolic compounds, saponins, triterpenoids and cardiac glycosides were also present in the leaves of P. indica. Absolute ethanolic extract of P. indica showed significant antimicrobial activity against all the tested pathogens, followed by aqueous extract. In concluded that, P. indica leaves crude extracts have wide range of bioactive compounds and which might be led to potential antimicrobial activity. They may lend to developing novel therapeutic agent to different infectious diseases.

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Song, Xiaozhe, and Aránzazu Díaz-Cuenca. "Sol–Gel Synthesis of Endodontic Cements: Post-Synthesis Treatment to Improve Setting Performance and Bioactivity." Materials 15, no. 17 (September 1, 2022): 6051. http://dx.doi.org/10.3390/ma15176051.

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The sol–gel process is a wet chemical technique that allows very fine control of the composition, microstructure, and final textural properties of materials, and has great potential for the synthesis of endodontic cements with improved properties. In this work, the influence of different sol–gel synthesis variables on the preparation of endodontic cement based on calcium silicate with Ca/Si stoichiometry equal to 3 was studied. Starting from the most optimal hydraulic composition selected, a novel second post-synthesis treatment using ethanol was essayed. The effects of the tested variables were analyzed by X-ray diffraction, infrared spectroscopy, scanning electron microscopy, nitrogen physisorption, and Gillmore needles to determine the setting time and simulated body fluid (SBF) immersion to measure the bioactive response in vitro. The results indicated that the sol–gel technique is effective in obtaining bioactive endodontic cements (BECs) with high content of the hydraulic compound tricalcium silicate (C3S) in its triclinic polymorph. The implementation of a novel post-synthesis treatment at room temperature using ethanol allows obtaining a final BEC product with a finer particle size and a higher CaCO3 content, which results in an improved material in terms of setting time and bioactive response.

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Lopes, Susana M. M., Cátia F. O. Correia, Sandra C. C. Nunes, Nelson A. M. Pereira, Ana R. F. Ferreira, Emanuel P. Sousa, Clara S. B. Gomes, Jorge A. R. Salvador, Alberto A. C. C. Pais, and Teresa M. V. D. Pinho e Melo. "Synthesis of chiral hexacyclic steroids via [8π + 2π] cycloaddition of diazafulvenium methides." Organic & Biomolecular Chemistry 13, no. 34 (2015): 9127–39. http://dx.doi.org/10.1039/c5ob01110h.

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Elsharabasy, Fatma, Sobhi Gomha, Thoraya Farghaly, and Heba Elzahabi. "An Efficient Synthesis of Novel Bioactive Thiazolyl-Phthalazinediones under Ultrasound Irradiation." Molecules 22, no. 2 (February 18, 2017): 319. http://dx.doi.org/10.3390/molecules22020319.

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Bejarano, Natividad, Leticia Lafuente, Juliana Esteche, Cintia C. Santiago, Agustín H. Rojas, and Agustín Ponzinibbio. "Synthesis and Structure of Novel Potentially Bioactive Amphiphilic -O-(N)-Glycosides." Chemistry Proceedings 3, no. 1 (November 14, 2020): 100. http://dx.doi.org/10.3390/ecsoc-24-08286.

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Herein we present the synthesis and structural analysis of novel -O-(N)-glycosides. The biphasic reaction of NHS and acetobromo-α-d-glucose or d-galactose gives the β anomer glycoside in a straightforward manner. Further hydrazinolysis and condensation with decanal afforded the desired products. Their complete structures, including the anomeric and E/Z double bond configurations, were determined by spectroscopic analysis.

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Díez‐Municio, Marina, Miguel Herrero, Agustín Olano, and F. Javier Moreno. "Synthesis of novel bioactive lactose‐derived oligosaccharides by microbial glycoside hydrolases." Microbial Biotechnology 7, no. 4 (April 2014): 315–31. http://dx.doi.org/10.1111/1751-7915.12124.

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Sakakibara, Norikazu. "Synthesis and Evaluation of Novel Nucleic Acid Derivatives as Bioactive Substances." YAKUGAKU ZASSHI 134, no. 9 (2014): 965–72. http://dx.doi.org/10.1248/yakushi.14-00175.

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Liu, Tao, Dongzhi Lai, Xinxing Feng, Hailin Zhu, and Jianyong Chen. "Synthesis and characterization of a novel mesoporous bioactive glass/hydroxyapatite nanocomposite." Materials Letters 92 (February 2013): 444–47. http://dx.doi.org/10.1016/j.matlet.2012.10.084.

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Khalid, H., N. Hussain, and A. S. Khan. "Synthesis and characterization of novel in-situ grafted bioactive dental fillers." Dental Materials 33 (2017): e42-e43. http://dx.doi.org/10.1016/j.dental.2017.08.083.

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