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Stewart, Mark Richard. "The design and synthesis of synthetic receptors." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400852.
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Zha, Huiyan, and 查慧艳. "Design, synthesis and characterization of synthetic ion transporters." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/206532.
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In recent decades, small molecules have been widely applied to the generation of functional ion transporters. Major discoveries disclosed in this thesis include a self-assembled chloride-dependent potassium channel candidate, a physiological chloride and bicarbonate dual-transporter, and a series of efficient synthetic ion transporters.
In nature, K+ channels play an important role in Ca2+ signaling, volume regulation, secretion, proliferation, and migration. The extracellular K+ concentration (4 mM) is about 40 times lower than the intracellular K+ concentration (160 mM). The opening of K+ channels consequently generates an efflux of positive charge, which hyperpolarizes or repolarizes the cellular membrane. In this research, by using fluorescence assays, NMR and patch clamp experiments, compound ZHY-CM23 was found to self-assemble into a chloride-dependent K+ selective channel mediating K+ transport across lipid bilayers and cell membranes. In addition, the synthetic K+ channel formed by ZHY-CM23 was found to be capable of generating and modulating the membrane potential of liposomes and to significantly hyperpolarize the resting membrane potential of HEK 293 cells. This finding provides new insight into developing drugs for the treatment of severe human diseases caused by K+ channel malfunction, such as arrhythmia, neurological disorders and autoimmune diseases.
Cystic fibrosis is a chronic recessive disease resulting from the loss of function mutations in the gene encoding of the cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ABC family of membrane transporters. Recent findings reveal that restoring bicarbonate transport might be useful for the treatments of the underlying defect in cystic fibrosis. On the basis of fluorescence assays, NMR and short circuit current experiments, the small molecule ZHY-CM11 has been discovered to not only act as a bicarbonate transporter in lipid membranes, but also to induce chloride-dependent bicarbonate secretion in cultured calu-3 epithelia. It is a promising lead compound to be developed for the treatment of cystic fibrosis and other diseases related to chloride and bicarbonate transport defects.
Through structural modifications on the bioactive ion channels and the transporters ZHY-CM23 and ZHY-CM11, some valuable information on the structure-activity relationship has been obtained, and a series of potentially biologically applicable synthetic ion transporters have been discovered.published_or_final_version
Chemistry
Doctoral
Doctor of Philosophy
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Shen, Yue. "Design, synthesis and characterization of the synthetic yeast genome." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33182.
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With the rapid development of DNA synthesis technologies, synthetic biology has made tremendous progress in the past 15 years, in particular for synthetic genomics. Synthetic genomics is a nascent field of synthetic biology, which aims to design new biological systems/organisms to satisfy human needs. Conventional synthetic biology focuses on the redesign, construction and modeling of biological parts, pathways or genomes that do not exist in nature, while synthetic genomics encompasses technologies that allow the generation of chemically synthesized larger parts of genomes or whole genomes, with simultaneous redesign of an organism's genetic material. Synthetic genomics is painting a blueprint for a new era of biology and holds great potential for a multitude of applications, such as pharmaceuticals, biofuels and rapid generation of vaccines against emerging diseases. Chapter One gives an introduction of the current state of the art and challenges of synthetic genomics and the objectives of this study. Chapter Two demonstrates the design and construction strategy of two megabase-long synthetic yeast chromosomes, SynII and SynVII. Chapter Three describes the full characterization of SynII and SynVII. Chapter Four introduces the SCRaMbLE (Synthetic Chromosome Rearrangement and Modification by LoxPsym-mediated Evolution) system and its application in SynII and SynVII. Taken together, this work demonstrates the utility of synthetic yeast for understanding biological systems and its potential for industrial applications.
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Baas, Tracey Lynn. "The design, synthesis, and characterization of template assembled synthetic proteins /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/11561.
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Murphy, Richard. "Constraint-based design synthesis for computer aided design." Thesis, Open University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418515.
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Smith, Kenneth Wayne. "Fighter Aircraft Synthesis/Design Optimization." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/32821.
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This thesis presents results of the application of energy-based large-scale optimization of a two-subsystem (propulsion subsystem (PS) and airframe subsystem-aerodynamics (AFS-A)) air-to-air fighter (AAF) with two types of AFS-A models: a fixed-wing AFS-A and a morphing-wing AFS-A. The AAF flies 19 mission segments of a supersonic fighter aircraft mission and the results of the study show that for very large structural weight penalties and fuel penalties applied to account for the morphing technology, the morphing-wing aircraft can significantly outperform a fixed-wing AAF counterpart in terms of fuel burned over the mission. The optimization drives the fixed-wing AAF wing-geometry design to be at its best flying the supersonic mission segment, while the morphing-wing AFS-A wing design is able to effectively adapt to different flight conditions, cruising at subsonic speeds much more efficiently than the fixed-wing AAF and, thus yielding significant fuel savings.
Also presented in this thesis are partially optimized results of the application of a decomposition strategy for large-scale optimization applied to a nine-subsystem AAF consisting of a morphing-wing AFS-A, turbofan propulsion subsystem (PS), environmental controls subsystem (ECS), fuel loop subsystem (FLS), vapor compression/polyalphaolefin loop subsystem (VC/PAOS), electrical subsystem (ES), central hydraulics subsystem (CHS), oil loop subsystem (OLS), and flight controls subsystem (FCS). The decomposition strategy called Iterative Local-Global Optimization (ILGO) is incorporated into a new engineering aircraft simulation and optimization software called iSCRIPTâ ¢ which also incorporates the models developed as part of this thesis work for the nine-subsystem AAF. The AAF flies 21 mission segments of a supersonic fighter aircraft mission with a payload drop simulating a combat situation. The partially optimized results are extrapolated to a synthesis/design which is believed to be close to the system-level optimum using previously published results of the application of ILGO to a five-subsystem AAF to which the partially optimized results of the nine-subsystem AAF compare relatively well.
In addition to the optimization results, a parametric study of the morphing AFS-A geometry is conducted. Three mission segments are studied: subsonic climb, subsonic cruise, and supersonic cruise. Four wing geometry parameters are studied: leading-edge wing sweep angle, wing aspect ratio, wing thickness-to-chord ratio, and wing taper ratio. The partially optimized AAF is used as the baseline, and the values for these geometric parameters are increased or decreased up to 20% relative to an established baseline to see the effect, if any, on AAF fuel consumption for these mission segments. The only significant effects seen in any of the mission segments arise from changes in the leading-edge sweep angle and wing aspect ratio. The wing thickness-to-chord ratio shows some effect during the subsonic climb segment, but otherwise shows no effect along with the taper ratio in any of the three mission segments studied. It should be emphasized, however, that these changes are made about a point (i.e. synthesis/design), which is already optimal or nearly so. Thus, the conclusions drawn cannot be generalized to syntheses/designs, which may be far from optimal. Also note that the results upon which these conclusions are based may very likely highlight a weakness in the conceptual-level drag-buildup method used in this thesis work. Further optimization studies using this drag-buildup method may warrant setting the thickness-to-chord ratios and taper ratios rather than having them participate in the optimization as degrees of freedom (DOF).
The final set of results is a parametric study conducted to highlight the correlation between the fuel consumption and the total exergy destruction in the AFS-A. The results for the subsonic cruise and supersonic cruise mission segments show that at least for the case when the AFS-A is optimized by itself for a fixed specific fuel consumption that there is a direct correlation between the fuel burned and total exergy destruction. However, as shown in earlier work where a three-subsystem AAF with AFS-A, PS, and ECS is optimized, this may not always be the case. Furthermore, based on the results presented in this thesis, there is a smoothing effect observed in the exergy response curves compared to the fuel-burned response curves to changes in AFS-A geometry. This indicates that the exergy destruction is slightly less sensitive to such changes.Master of Science
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Ye, Yulin. "Design and synthesis of myo-inositol (1,4,5)-trisphosphate receptor antagonists : design and synthesis of IP3 receptor antagonists." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:5e75b5e0-d42a-4b58-9c46-7fabff99e10e.
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Well-regulated Ca2+ signalling is essential for every living organism, and disruption of this signalling can lead to diseases including heart failure, neurological disorders and diabetes. Intracellular Ca2+ levels are regulated by influx of extracellular Ca2+ through channels located in the cell membrane. In addition, release of Ca2+ from intracellular stores also plays an important role in controlling intracellular Ca2+ concentration. Of the three types of intracellular Ca2+ stores that have been characterised those with D-myo-Inositol 1,4,5 trisphosphate receptors (InsP3Rs) showed a close relationship with cell proliferation. Hence, selective blockage of InsP3Rs will allow better understanding of Ca2+ signalling and might also unveil novel treatment for cancers, in the long term. There were no selective InsP3Rs antagonists known at the start of these studies. Based on the crystal structure of InsP3Rs bound to InsP3 and SAR studies of InsP3, we designed and tested several InsP3 analogues.1 Compound 15, 16 and 23 acted as InsP3R antagonists, though their selectivity for InsP3Rs was not completely determined. Furthermore, we also attempted to improve the potency of 16 via substitution at the 1-postion phosphate. By considering the interaction formed between adenophosphostins and InsP3Rs compounds (53-55) were designed and synthesised. In addition, analogues of compound 92, selected from an in silico screen, have led to the discovery of another novel scaffold that acts as an InsP3R antagonist.
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Lange, Mark W. "Design semiosis : synthesis of products in the design activity /." Stockholm, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3243.
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Engelsen, Frode. "Design-oriented gust stress contraints for aeroservoelastic design synthesis /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/9965.
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Sun, Xiaojiao. "High Affinity Synthetic Molecular Binders for Proteins : Design, Synthesis and Evaluation." Doctoral thesis, Uppsala universitet, Fysikalisk-organisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183203.
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This thesis describes the design and synthesis of small molecule derivatives and their polypeptide conjugates as high affinity binders for proteins: the D-dimer protein (D-dimer), a biomarker for diagnosis of thromboembolic diseases; human myeloperoxidase (MPO), a biomarker for cardiovascular diseases; and chitinases, potential targets for asthma therapy. The interactions between the synthetic binder molecules and those proteins were evaluated by surface plasmon resonance (SPR) biosensor analysis and fluorescence spectroscopy. Competition SPR experiments or other methods proved that the small molecule components of the binder molecules were critical for binding and specifically bound to the original binding site of small molecules. The binder molecules consisted of a 42-residue helix-loop-helix polypeptide conjugated to a small molecule via aliphatic spacers of suitable length. The small molecules could be any type of moderately binding structure. In the binder development for the D-dimer, the tetrapeptide GPRP with a dissociation constant Kd of 25 μM was used and the affinity of 4C15L8GPRP obtained was estimated to be approximately 3 nM. In the binder development for MPO, salicylhydroxamic acid (SHA) with Kd of 2 μM was used and the affinity of 4C37L34C11SHA obtained was estimated to be approximately 0.4 nM. In the binder development for chitinases, a theobromine derivative (pentoxifylline) with a Kd of 43±10 μM was used and the affinity of 4C37L34-P obtained was estimated to be considerably higher than that of pentoxifylline. The binder molecules were identified from a 16-membered pool of candidates obtained by conjugating the small molecules to each member of a set of 16 designed polypeptides. The affinities were greatly enhanced by 2-3 orders of magnitude, compared to the small molecule. The polypeptides did not bind to the proteins with measurable affinities. The discovery of these new synthetic binders for protein targets can pave the way to diagnostic tests in vivo or in vitro, independent of antibodies.
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Yu, Zutao. "The design, synthesis and evaluation of synthetic transcription factors (Syn-TFs)." Kyoto University, 2018. http://hdl.handle.net/2433/235052.
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Nouar, Farid. "Design, Synthesis and Post-Synthetic Modifications of Functional Metal-Organic Materials." Scholar Commons, 2010. https://scholarcommons.usf.edu/etd/1725.
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Porous solids are a class of materials of high scientific and technological significance. Indeed, they have the ability to interact with atoms, ions or molecules not only at their surface but also throughout the bulk of the solid. This ability places these materials as a major class involved in many applications such as gas storage and separation, catalysis, drug delivery and sensor technology.
Metal-Organic Materials (MOMs) or coordination polymers (CPs) are crystalline compounds constructed from metal ions or clusters and organic components that are linked via coordination bonds to form zero-, one-, two or three-periodic structures. Porous Metal-Organic Materials (MOMs) or Metal-Organic Frameworks (MOFs) are a relatively new class of nanoporous materials that typically possess regular micropores stable upon removal of guests. An extraordinary academic and industrial interests was witnessed over the past two decades and is evidenced by a fantastic grow of these new materials. Indeed, due to a self-assembly process and readily available metals and organic linkers, an almost infinite number of materials can, in principle, be synthesized. However, a rational design is very challenging but not impossible. In theory, MOMs could be designed and synthesized with tuned functionalities toward specific properties that will determine their potential applications.
The present research involves the design and synthesis of functional porous Metal-Organic Materials that can be used as platforms for specific studies related to many applications such as for example gas storage and particularly hydrogen storage. In this manuscript, I will discuss the studies performed on existing major Metal-Organic Frameworks, namely Zeolite-like Metal-Organic Frameworks (ZMOFs) that were designed and synthesized in my research group. My research was also focused on the design and the synthesis of new highly porous isoreticular materials based on Metal-Organic Polyhedra (MOP) where desirable functionality and unique features can be introduced in the final material prior and/or after the assembly process. The use of hetero-functional ligands for a rational design toward binary or ternary net will also be discussed in this dissertation.
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Jawed, S. M. A. H. "Sensitivity applications in structural design synthesis." Thesis, Cranfield University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356199.
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Yayla, Ihsan. "Filter Design Software By Synthesis Method." Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12610279/index.pdf.
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In this study, Window-based computer program, named Synthesis Software, is developed for
designing filters with equal-ripple or maximally flat passbands and general stopbands by using
cascade synthesis technique in transformed frequency domain. Synthesis technique is applicable
to lumped element and commensurate line distributed element filters with Lowpass,
Highpass or Bandpass characteristics. Singly or Doubly terminated filters can be synthesized. friendly environment for typing in the parameters of the filter to be designed. This part uses
Synthesis and Plot parts as modules.
This software is based on the previous softwares developed in EEE Department of Middle
East Technical University. All the previous softwares were gathered in the well-known software
Filpro, which is in DOS environment, in Pascal. Thus, the new software is actually a
conversion of Synthesis part of Filpro from DOS environment into Windows environment in
the language C#, with some improvements in root finding algorithms for numerical conditioning.
Synthesis Software is has three parts. The first and main part is the implementation
of synthesis technique by using object oriented programming technique. In this way, synthesis
technique implementation is isolated from other parts of Synthesis Software and it can be
used by other filter design programs as a module. The second part of the program is responseplotting
section. In this part Insertion Loss, Return Loss, Time Delay, Phase and Smith Chart
responses are calculated and displayed. The last part is User Interface, which provides user
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Xu, Hao. "Synthesis and design of PID controllers." Texas A&M University, 2004. http://hdl.handle.net/1969.1/1480.
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controllers for discrete-time systems and time-delayed systems. By using bilinear
transformation and orthogonal transformation, earlier research results obtained in
the continuous-time case are extended to discrete-time situation. The complete set of
stabilizing PID controllers for the discrete-time systems is thus obtained. Moreover,
this set remains to be a union of convex sets when one particular parameter is fixed.
Thus a method to design robust and non-fragile digital PID controllers is proposed
by following a similar design procedure for the continuous-time systems. In order to
find the stabilizing controller set for systems with time-delays, the relationship between
the Nyquist Criterion and Pontryagins theory is investigated. The conditions
under which one can correctly apply the Nyquist Criterion to time-delayed systems
are derived. Then, the complete set of stabilizing PID controllers for arbitrary order
LTI systems with time-delay up to a given value is obtained. Furthermore, the stability
issue of a system with fixed-delay is also studied and a formula which provides
complete knowledge of the distribution of the closed-loop poles is presented. Based
on this formula, stabilizing P and PI controller sets for the system with fixed-delay
can be computed.
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Hwang, Yves. "An automated software design synthesis framework." University of Western Australia. School of Electrical, Electronic and Computer Engineering, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0157.
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This thesis presents an automated software design synthesis framework known as Project Calliope. This framework aligns with Harel's automated software development process as it addresses the aspect of automating design and implementation. Project Calliope is based on a Statecharts synthesis approach in the literature. The main goal of Project Calliope is to automatically generate testable Unified Modeling Language (UML) Statecharts that are deterministic, visually manageable and UML compliant. In order to minimise design errors in the generated UML Statecharts, Project Calliope supports model checking through Statecharts execution. In addition, executable code is automatically generated based on the synthesised UML Statecharts. This framework seeks to provide a pragmatic design framework that can be readily incorporated into software development methodologies that leverage UML. In this thesis, Project Calliope is applied to three simple applications from Whittle and Schumann's examples and a case study based on a commercial application. They are automatic teller machine, coffee dispenser, an agent application, and a groupware application respectively.
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Findlay, Brandon. "Design and synthesis of cationic amphiphiles." American Society for Microbiology, 2010. http://hdl.handle.net/1993/21708.
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Cationic antimicrobial peptides (CAMPs) are produced by plants, animals and bacteria to protect their host against antagonistic microbes. The antitheses of selective antibiotics, these peptides are drawn by electrostatic and hydrophobic interactions to targets as diverse as the bacterial membrane, nucleic acids and serum proteins. This lack of specificity is their greatest strength, as mutations to single genes rarely lead to bacterial resistance. Resistance may be conferred by large scale alterations in cell envelope composition, which generally reduces bacterial fitness in the absence of peptide.
Clinical applications of natural CAMPs are limited, as the peptides are toxic to mammalian cells and rapidly inactivated in vivo by serum albumin and proteases. Faced with these challenges we have prepared a number of CAMP analogues, with the goal of creating lead compounds for further development of antibacterial therapeutics. Much of our work has focused on ultrashort lipopeptides and lipopeptoids, which have properties similar to natural CAMPs and extremely abbreviated sequences. The simple structure of these scaffolds allows rapid creation of CAMP analogues in a brief period of time, allowing us to rapidly explore the structural requirements for CAMP activity. The balance of this work focuses on imparting CAMP-like behaviour to known antibiotics, in order to expand their spectrum of susceptible bacteria and combat the development of drug-resistant bacteria. In particular, the aminoglycosides neomycin and tobramycin have been fused to phenolic disinfectants such as triclosan and biclotymol, in order to improve their diffusion across the bacterial envelope and activity against Gram-negative bacteria.
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Huot, Mitchell. "Design and synthesis of peptidomimetic scaffolds." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95192.
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Despite their promising biological activity, peptides have a number of unfavorable properties that hinder their ability to be drugs. Namely, peptides have poor bioavailability due to the proteases in the body that break them down. Also, peptides can often be substrates for numerous enzymes, therefore their selectivity can be quite poor. With this in mind, we aimed to design a series of constrained peptidomimetics designed to mimic dipeptide, while at the same time introducing conformational restraint in an attempt to improve selectivity, and they were designed without peptide bonds that could be cleaved by the body's proteases. In addition, these peptidomimetics were designed to be synthesized inexpensively and efficiently. The dipeptide-like linkages were designed to be introduced modularly and chemical handles were built into the design of molecule so that further functionalization would be simple. In this way, the molecule not only can act as a dipeptide mimetic but as a potential drug discovery platform for combinatorial chemistry. With this platform or scaffold, functional groups can easily be deployed in order to probe the geometric and electronic space of enzymes or receptors. During the process of the synthesis of these drug scaffolds we discovered we could increase the diastereoselectivty of the venerable Diels-Alder reaction by running the reaction in less solvophobic solvents.Malgré leurs activités biologiques intéressantes, les peptides ont certaines propriétés peu favorables à leur conversion en médicaments. Pour exemple, les peptides sont rarement biodisponibles en raison des protéases présentes dans les milieux biologiques. Ces proteases les découpent en fragments plus petits qui peuvent a leur tour présenter diverses activités biologiques. De plus, les peptides peuvent se lier à diverses enzymes et récepteurs, réduisant ainsi leur sélectivité pour une protéine cible donnée. Dans ce contexte, nous avons conçu une série de peptidomimétiques susceptibles de mimer des dipeptides naturels. L'incorporation de contraintes géométriques nous permet d'envisager une meilleure sélectivité pour une cible donnée alors que la réduction du nombre de liaisons amides devrait réduire leur protéolyse. La conception de ces molécules s'est également faite dans le contexte d'une accessibilité synthétique. La synthèse et la structure de ces molécules nous permettra une grande modularité alors que les groupements fonctionnels autour du cur bicyclique pourront être utilisés comme autant de points d'ancrage pour l'introduction de diversité chimique et structurale. Ainsi, ces molécules peuvent agir à titre de mimes de dipeptides mais aussi comme plateforme en synthèse combinatoire. Dans ce dernier cas, divers groupes fonctionnels peuvent être attachés sur les deux points d'ancrage. Au cours du développement de la voie synthetique, nous avons mis a jour le lien entre la diastéréosélectivité de la réaction de cycloaddition intramoléculaire de Diels-Alder et la solvophobicité des solvants de réaction.
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Cauet, Solene. "Design, Synthesis andCharacterisation of Reactive StarPolymers." Thesis, University of Warwick, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502531.
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The objective of this thesis was to prepare well-defined succinimide-functional star polymers by copper(I) catalysed living radical polymerisation. Atom transfer radical polymerisation (ATRP) was used to prepare copolymers incorporating the activated ester methacrylate monomer Nmethacryloxysuccinimide (NMS) and butyl methacrylate (BMA). First, welldefined pure 5-arm star block copolymers were prepared by polymerisation of BMA from a glucose-core initiator to produce star homopolymers which were then used as macroinitiators for the polymerisation of NMS. Thereafter, welldefined pure 5-arm star statistical copolymers and copolymers with a pure BMA block and a statistical block were produced. Good control over the kinetics and molecular weights was achieved. The molecular weights of the copolymers were confirmed by gel permeation chromatography with low-angle laser light scattering detection (GPC-LALLS) and their compositions via IH NMR and elemental analysis. Well-defined styrene 5-arm star polymers were synthesised via ATRP from a glucose core. 'Click chemistry' was used to end-functionalise two star polymers of different molecular weights by converting the chain-ends to azide groups after which the resulting polymers were clicked with three alkyne compounds with biotin, coumarin and succinimide functionality. IH NMR, FTIR, GPC, GPCLALLS and MALDI-TOF analyses confirmed the success of the click reactions. Finally, the reaction of poly(BMA-co-NMS) copolymers with amines was studied by FTIR, GPC and IH NMR. It was observed that the reactions followed first-order kinetics with respect to the quantity of succinimidyl groups. The presence of ring-opened side product was shown by IH NMR and signs of this side reaction were also observed with GPC-UV analysis. The results of this study were used to prepare derivates of a 5-arm statistical BMA-NMS star copolymer precursor with 5 different amines. The final products were analysed by IH NMR to measure conversion of succinimidyl groups and amount of side-product and by GPC-LALLS to obtain molecular weights. The solubility of the derived polymers was also assessed in a number of different solvents.
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Rai, Prabin. "Design and synthesis of fluorescent probes." Thesis, Kent State University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3618852.
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The fundamental objective of this project is to design, synthesize, and characterize fluorescent dyes, which may be utilized in super resolution imaging techniques. In Chapters 1, 2 and 3, we concentrated on photoswitchable rhodamine dyes. We synthesized several rhodamine dyes and increased their water solubility, installed a bioconjugation unit and, more importantly, we optimized the absorption properties (close to 400 nm) of the rhodamine spirolactams in their closed state and studied their basic photophysical properties as well. In Chapter 4, we synthesized azido-DCDHF fluorogens that can be converted to the bright state after a 1,3-dipolar cycloaddition reaction between an azide-Ph-DCDHF and a strained alkene. We synthesized some strained alkenes, which may speed up the kinetics in 1,3-dipolar cycloaddition. This chemical method of turning the dyes from dark to bright state is a new dimension in the bioconjugation arena. In Chapter 5, we synthesized Nile red derivatives which can switch to a bright state from a dark state by collision on the cell surface utilizing PAINT methodology. We expected that the design of new Nile red derivatives may have better properties than the parent Nile red. Besides the PAINT technique, we worked on some active control of emission by enzymatic cleavage of fluorescent dyes in a dark state to the bright state, which can be utilized in super resolution imaging. Related to the 1,3-dipolar cycloaddition reaction between azido-DCDHF and norbornene, we have examined recently popularized tetrazine chemistry. We linked pyridyl tetrazines to DCDHF with short spacer. In Chapter 6, we describe the preparation of co-crystals between perfluorophenazine and several polynuclear aromatic compounds/polynuclear heteroaromatic compounds. In Chapter 7 we describe the preparation of some partially fluorinated heteropolynuclear aromatic compounds such phenzaine and acridine class of compounds for possible use in organic semiconductors.
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Mulqueen, Gerard C. "Siderphores : design, synthesis, and biological evaluation." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358061.
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Bennett, Fiona Catherine. "Design and synthesis of model peptides." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299882.
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Potter, Stephen. "Artificial intelligence and conceptual design synthesis." Thesis, University of Bath, 2000. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760733.
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Trask, Andrew Vincent. "Pharmaceutical cocrystals : design, synthesis and analysis." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613783.
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Faulkner, Alan D. "Design and synthesis of triplex metallohelices." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/63680/.
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Chapter 1 introduces the concept of π-stacking. Different literature interpretations based on both model systems and theoretical observation are discussed. Chapter 2 describes how π-stacking interactions in a series of [ZnLn3]2+ complexes are affected by the incorporation of ring substituents by focusing on the fac:mer selectivity of these systems. The stability of Fe(II) complexes to undergo further functionalization post complexation is also investigated, in particular their ability to undergo copper(I)-catalysed Huisgen 1,3-dipolar cycloaddition 'click' reactions. Chapter 3 focuses on the use of inter-ligand π-stacking interactions in the formation of asymmetric, bimetallic coordination complexes that we have termed triplexes metallohelices. The selectivity of these systems has been investigated by computational means. The structure has been confirmed by both solution and solid state measurement. In addition the inherent stability of these complexes to functionalization, both pre and post complexation, is also discussed. Chapter 4 focuses on the synthesis of water soluble variants of triplex metallohelices and their potential biological applications. In particular their anti-cancer properties are presented in detail. Chapter 5 details the experimental procedures used to carry out the work in this thesis.
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MacQuarrie, Stephanie Lee. "Design and Synthesis of Novel Benzodiazepines." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/30209.
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Bivalent drug design is an efficient strategy for increasing potency and selectivity of many drugs. We devised a strategy to prepare agonist-benzodiazepine heterodimers that could simultaneously bind to agonist and BZD sites of the GABAAR. We synthesized a benzodiazepine-MPEG model compound that relied on physiological GABA to elicit flux. We established that a tether at the N1 position of the BZD would not prevent binding to the receptor. However, coupling of GABA amides with long chain PEG tethers studied by another group member resulted in complete loss of agonist activity. We therefore ceased research in this particular area.
1,4-Benzodiazepin-2,5-diones display a wide range of pharmacological activities. Compounds containing the tricyclic proline-derived subtype have received attention as potent anxiolytic agents and as starting materials for anthramycin-inspired anticancer agents. More recently enantiopure (S)-proline-derived 1,4-benzodiazepin-2,5-diones have been recognized as selective α5 GABAA receptor ligands. Despite the impressive diversity of 1,4-benzodiazepine-2,5-diones prepared to date, enantiopure examples possessing a quaternary stereogenic center have been largely unexplored.
"Memory of chirality" (MOC) is an emerging strategy for asymmetric synthesis. This technique enables the memory of a sole chiral center in the substrate to be retained in a process that destroys that center. We have used this technique to prepare a library of quaternary proline-derived, thioproline-derived and hydroxyproline-derived 1,4-benzodiazepin-2,5-diones, in high ee. We have developed an efficient synthetic method for preparing oxaproline-derived 1,4-benzodiazepin-2,5-diones in high yields, and by applying the MOC strategy we have prepared quaternary derivatives in acceptable %ee. We envision oxaproline-derived 1,4-benzodiazepin-2,5-diones may exhibit similar or more potent pharmacological properties than proline-derived 1,4-benzodiazepin-2,5-diones. Using density functional theory (DFT) methods, we modeled the formation of an enantiopure, dynamically chiral enolate intermediate and the slow racemization of the enolate on the alkylation reaction time scale.Ph. D.
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Kennedy, R. Scott. "Synthesis of chaos theory & design." Thesis, Virginia Tech, 1994. http://hdl.handle.net/10919/42000.
Full textAbstract:
The design implications of chaos theory are explored. What does this theory mean, if anything, to landscape architecture or architecture?
In order to investigate these questions, the research was divided into four components relevant to design. First, philosophical- chaos offers a nonlinear understanding about place and nature. Second, aesthetical- fractals describe a deep beauty and order in nature. Thirdly, modeling-it is a qualitative method of modeling natural processes. Lastly, managing- concepts of chaos theory can be exploited to mimic processes found in nature. These components draw from applications and selected literature of chaos theory.
From these research components, design implications were organized and concluded. Philosophical implications, offer a different, nonlinear realization about nature for designers. Aesthetic conclusions, argue that fractal geometry can articulate an innate beauty (a scaling phenomenon) in nature. Modeling, discusses ways of using chaos theory to visualize the design process, a process which may be most resilient when it is nonlinear. The last research chapter, managing, applications of chaos theory are used to illustrate how complex form, like that in nature, can be created by designers.
Master of Landscape Architecture
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Rai, Prabin. "Design and Synthesis of Fluorescent Probes." Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1375091914.
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Wu, Qiong. "Synthesis of Polycatenanes Through Molecular Design." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1480950518125291.
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Bibel, John Eugene. "Missile autopilot design using Mu-Synthesis." Thesis, This resource online, 1998. http://scholar.lib.vt.edu/theses/available/etd-08252008-161841/.
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Thorp, Tyler J. A. "Design and synthesis of dynamic circuits /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/6102.
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Wood, Virginia Ann. "Design and synthesis of novel antioxidants." Thesis, University of Bath, 1999. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301963.
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Hu, Yaogang. "Design and Synthesis of Bioactive Peptidomimetics." Scholar Commons, 2015. https://scholarcommons.usf.edu/etd/5504.
Full textAbstract:
Protein-Protein Interactions (PPIs) play a very important role in biological functions and therefore the inhibition of specific Protein-Protein Interactions has a huge therapeutic value. The most successful small molecular PPIs inhibitors do not fit with the prevalent `Rule of Five' drug profile. To overcome the disadvantages of small molecular PPIs inhibitors, peptide based PPIs inhibitors were developed. Herein we describe the development of a new class of peptidomimetics AA-peptides. The AApeptides were designed based on chiral PNA backbone. Substitution of nucleobases yields AApeptides that are resistant to proteolysis and capable of mimicking peptides. Two types of AApeptides were discussed in this dissertation "α-AApeptides" and "γ-AApeptides". The AApeptides were shown to disrupt p53/MDM2 protein-protein interaction and tomimic fMLF tripeptide to target G protein-coupled formyl peptide receptors (FPRs). Moreover, the lipidated α-AApeptides can mimic the structure and function of natural antimicrobial lipopeptides and show broad-spectrum activity against both Gram-positive and Gram-negative bacteria. Lastly I have designed and synthesized a serials of phosphopeptides to disrupt cancer related STAT3-STAT3 dimerization.
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Gide, Mussie. "Design, Synthesis, Application of Biodegradable Polymers." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7625.
Full textAbstract:
Bacterial infections have posed a serious threat to the public health due to the significant rise of the infections caused by antibiotic-resistant bacteria. There has been considerable interest in the development of antimicrobial agents which mimic the natural HDPs, and among them biodegradable polymers are newly discovered drug candidates with ease of synthesis and low manufacture cost compared to synthetic host defense peptides. Herein, we present the synthesis of biocompatible and biodegradable polymers including polycarbonate polymers, unimolecular micelle hyperbranched polymers and dendrimers that mimic the antibacterial mechanism of HDPs by compromising bacterial cell membranes. The developed amphiphilic polycarbonates are highly selective to Gram-positive bacteria, including multidrug-resistant pathogens and the unimolecular micelle hyperbranched polymers showed promising broad-spectrum activity. However, lipidated amphiphilic dendrimers with low molecular weight display potent and selective antimicrobial activity against both Gram-positive and Gram-negative bacteria, including multidrug-resistant strains. In addition to antibacterial activity against planktonic bacteria, these dendrimers were also shown to inhibit bacterial biofilms effectively. These class of polymers may lead to a useful generation of antibiotic agents with practical applications.
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Chua, Shin Cheng. "Design and synthesis of reversible logic." Thesis, Curtin University, 2016. http://hdl.handle.net/20.500.11937/1504.
Full textAbstract:
Energy lost during computation is an important issue for digital design. Today, all electronics devices suffer from energy lost due to the conventional logic system used. The amount of energy loss in the form of heat leads to immense challenges in nowadays circuit design. To overcome that, reversible logic has been invented. Since properties of reversible logic differ greatly than conventional logic, synthesis methods used for conventional logic cannot be used in reversible logic. In this dissertation, we proposed new synthesis algorithms and several circuit designs using reversible logic.
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Jung, Yong-Kyu. "Model-based processor synthesis." Diss., Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/14451.
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Topping, Chris Mark. "Design and synthesis of chiral ligands for copper catalysed asymmetric synthesis." Thesis, University of Hull, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301496.
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Gopinath, Smitha. "Molecular design, process design and process synthesis of separation systems." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/59004.
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The simultaneous solution of the optimal process variables and optimal processing materials for a separation system is considered in this work. The processing materials (or molecules) may include, amongst others, reaction medium solvents, catalysts and mass separating agents. In this thesis, the processing materials to be designed are restricted to pure component solvents that act as mass separating agents. The design of fluid-fluid separation systems at steady state is considered in this work. In the first part of the thesis, the process topology is fixed and the process variables are continuous whereas the molecular variables, used to describe the solvent, are discrete. The computer aided molecular and process design problem (CAMPD) is a challenging mixed integer nonlinear programming problem (MINLP). A deterministic optimization algorithm tailored to the CAMPD of separation systems is proposed. Novel tests are embedded within an iterative MINLP solution framework. The tests may eliminate infeasible regions of both the molecular and process domain. The algorithm is applied to a case study of separation of carbon dioxide and methane. In the second part of the thesis, the scenario where the process variables are both continuous and discrete is considered. Chemical process synthesis is the activity of determining the optimal process units and their connectivity in a process. Process synthesis is a highly combinatorial problem which is challenging, even with fixed material decisions. A formulation for process synthesis problems is presented which addresses numerical singularities that are encountered when a process unit is not selected. The computer aided molecular and process synthesis (CAMPS) problem is considered next where the degrees of freedom include material and process synthesis decisions. An algorithm for CAMPS is developed by extending the CAMPD algorithm. A CAMPS case study of separation of butanol and water is modelled using the process synthesis formulation developed in this thesis. The tests can eliminate infeasible portions of the molecular domain and both continuous and discrete process domains. Both the CAMPD and CAMPS algorithms proposed here avert evaluations of infeasible primal problems and enhance convergence to solutions of challenging design problems.
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Slowey, Aine. "Design and synthesis of inositol phosphate-based probes." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:62687744-69b5-420c-9afa-b549bbe39ec4.
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Inositol phosphates play a fundamental role in many intracellular processes. Of particular importance is the role of phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] in the protein kinase B (PKB/Akt) signalling pathway. PtdIns(3,4,5)P3 recruits PKB to the cell membrane through binding interactions with its pleckstrin homology (PH) domain. In several human cancers, this signalling pathway is upregulated, resulting in increased cell growth and proliferation. In order to investigate the therapeutic potential of the PtdIns(3,4,5)P3–PH domain binding interaction, it is necessary to develop inositol phosphate-based probes. This DPhil dissertation highlights the synthesis of a number of derivatives of the PtdIns(3,4,5)P3 head group – inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4]. These derivatives incorporated phosphate isosteres at both the 3- and 5-positions of Ins(1,3,4,5)P4, through the utilisation of novel protection and deprotection strategies. In addition, this dissertation highlights the efficient synthesis of the natural product inositol 1,3-bisphosphate [Ins(1,3)P2] and our work towards the synthesis of inositol pyrophosphate derivatives.
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Sismour, A. Michael. "The design and synthesis of a genetic system for a synthetic biology." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0012925.
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Chen, Wei. "Design, Synthesis and Biological Evaluation of Synthetic Inhibitors Directed Against Cathepsin S." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501243.
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Lewis, Kemper E. "An algorithm for integrated subsystem embodiment and system synthesis." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/16025.
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Hadjinicolaou, M. G. "Synthesis of programmable logic arrays." Thesis, Brunel University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371168.
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Serghides, V. C. "Design synthesis for Canard-Delta combat aircraft." Thesis, Cranfield University, 1987. http://hdl.handle.net/1826/3300.
Full textAbstract:
This . thesis pr*esents the development of a computerized
Design Synthesis for canard-delta combat aircraft. This is
complementary to and followas the philosophy of an existing
RAE system for conventional combat aircraft with swept wings
(Ref. 1).
The background to the work and the Research Progra
objectives and limitations are initially examined. The
design of a baseline canard-delta combat aircraft is then
described together with all the assumptions and decisions
which led to its final configuration.
The philosophy behind the progressive evolution of the
aircraft geometry and packaging modules from the baseline
configuration, is explained in detail. The development of
detailed modules'for the estimation of the aircraft
aerodynamics and performance is then presented. A full
description of the investigations into the effects of
canard-delta interference on the aircraft aerodynamics, is
also included. The mathematical content of the aircraft
geometry, packaging, aerodynamics and performance modules is
presented separately in the appendices, in greater detail.
The development and architecture of the Design
Synthesis and graphics programs are finally presented and
the program operation is described with the aid of flow-
charts. A comprehensive user's manual and a design example
are also provided.
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Williams, Greville Wade. "Multi-objective process synthesis, and a post synthesis environment for process design." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/14670.
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This thesis describes a process design procedure incorporating early consideration of extra design criteria. Traditionally cost is used as the main criterion to select a design alternative, but the design specification frequently has approximations and uncertainties associated with it. Further criteria for evaluating processes can be used to help the designer differentiate between alternatives. Synthesis is carried out on a cost basis selecting the n best processes based upon cost. The synthesis output is reassessed on the grounds of safety, environmental impact, flexibility etc. The methods are applicable to conceptual design and form the basis of further analysis. Where transparency and flexibility is required in the analysis, external packages are used. A post synthesis environment is described which stores the extra data required to perform the procedure and enables a collection of processes to be examined. Relationship assessments and value based assessments are applied to conflicting criteria so that a process ranking can be made. The procedure has been applied to two case studies in the manufacture of hydrogen cyanide and ethylene. The studies show how the method can be applied and demonstrates that the design selected upon a cost basis alone may not be the optimal design. The procedure demonstrates the requirement that the assessment package and synthesis package are linked to ensure consistency of the data set, and a record of all previous data sets are maintained. The cost of incorporating inherent features into a design can be evaluated and inferior designs can be removed from further consideration. By assessing the process alternatives early on in the design, development time can be reduced and the designers attention can focus upon the best process alternatives.
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Shu, Hong. "Design and Synthesis of CB1 Receptor Ligands and Synthesis of Amphibian Alkaloids." ScholarWorks@UNO, 2009. http://scholarworks.uno.edu/td/1104.
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Our project was aimed at the development of novel CB1 cannabinoid receptor antagonists that may have clinical applications for the treatment of cannabinoid and psychostimulant addiction. In this study, we designed, synthesized, and established the CB1 affinity for the 1,5-diaryl-1,2,3- triazole esters, a series of 4,5-diaryl-1-substituted-1,2,3-triazole analogues and a series of 4,5- diaryl-2-substituted-1,2,3-triazoles. Our research group has been interested in the synthesis of amphibian alkaloids due to their interesting biological activities. We have recently developed a general synthetic strategy which can rapidly prepare a few amphibian alkaloids simply from the abundant natural product (-)- cocaine This strategy was first successfully applied to the synthesis of (-)-monomorine. More recently, this strategy has also been utilized in the syntheses of both of the enantiomers of cispyrrolidine 225H and (+)-gephyrotoxin 287C.
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Johnson, Polly. "Synthesis as a Method for Elaboration." VCU Scholars Compass, 1994. https://scholarscompass.vcu.edu/etd/5534.
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Before I began this thesis, I examined my previous work and a consistent quality emerged. l tended to assemble (synthesize) things (entities) that were seemingly unlike (disparate). I q u e s t i o n e d my approach and its validity as a design methodology.
I found, through investigation into the nature of my p r o c e s s and the process of other artists and designers that specific methods of synthesis could be defined. In this thesis I have outlined three synthesis methodologies. They are not the only methods that exist, but were the ones I focused on for my thesis project.
After l defined these methods of synthesis and did visual and verbal explorations, the possibility of developing a process for generating visual and verbal content occurred to me. I was not sure what the effects of the process would be. It was not until after the thesis exhibition that I realized I had developed a process of elaboration.
For the thesis exhibition I created two and three dimensional exercises based on v i s u a I + v e r b a I combinations These studies were then applied for the purposes of the exhibition.
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Morris, Michael. "The design and synthesis of rubber toughened thermoplastics." Thesis, Sheffield Hallam University, 1988. http://shura.shu.ac.uk/20084/.
Full textAbstract:
To produce an impact toughened grade of 'Victrex' Polyethersulphone by blending with (A-B)n type Polyethersulphone/Poly(dimethylsiloxane ) [P.E.S./P.D.M.S.] block copolymers. A number of novel (A-B)n type P.E.S./P.D.M.S. block copolymers of varying block molecular weights have been synthesised and characterised. These have been melt blended with pure 4800P grade P.E.S. to yield a series of 'impact modified' P.E.S./P.E.S.-co-P.D.M.S. blends. Standard Izod and Tensile test pieces have been injection moulded from these blends, and these test pieces used in a study of the physical, chemical and mechanical properties of the blends. The melt shear viscosity of P.E.S. has been found to be substantially reduced by the presence of P.E.S./P.D.M.S. copolymers. This is believed due, at least in part, to the migration of the P.O.M.S. bearing copolymer to the surface of the blend during processing. Improvements in sharp notch impact strength of up to 43% have been observed in P.E.S./P.E.S.-co-P.D.M.S. blends containing as little as 2.5% copolymerised P.O.M.S. These improvements have been achieved at the expense of more modest reductions (no more than 24%) in tensile strengths. Examination of impact fracture surfaces has revealed that the copolymers promote localised plastic deformation in sharply notched P.E.S., the copolymer particles themselves undergoing cavitation during crack propagation. It has also been shown, however, that the copolymers suppress the gross plastic deformation usually observed in unnotched or bluntly notched P.E.S. The additive particles promote crack initiation in such specimens, and although they also facilitate localised plastic deformation, the overall result is usually a decrease in P.E.S. impact strength. Significantly, blends containing P.E.S. and P.E.S./P.O.M.S. copolymers do not appear to perform any better under impact than simple physical blends of P.E.S. and linear P.D.M.S. This is believed to be due to migration of the P.D.M.S. domains to the surface of the P.E.S./P.D.M.S. copolymers. Once at the surface, they inhibit the formation of the desired adhesive bond between the P.E.S. matrix and the P.E.S. domains in the copolymer. The presence of the copolymers does not appear to have any significant effect on the mechanical performance of P.E.S. as tested after immersion in a range of organic and inorganic reagents at room temperature.
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Lando, Alisa. "The Design and Synthesis of a First Aid Smart Fabric and Synthetic Studies Towards the Total Synthesis of Torilin." Thesis, Boston College, 2013. http://hdl.handle.net/2345/3235.
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Thesis advisor: Marc L. SnapperChapter 1: The design of a novel first aid smart fabric that is linked to a biologically active molecule through an event specific cleavable linker is described. Successful functionalization of a cellulose filter paper fabric mimic and the synthesis of a linker which is potentially selectively cleavable in the presence of blood have been achieved. Chapter 2: Synthetic studies towards the total synthesis of Torilin, a sesquiterpene guaiane natural product with interesting biological activities are described. The synthesis of the hydroazulene core of Torilin is accomplished through a cyclopropanation/ Lewis acid mediated fragmentation of a highly functionalized polycyclic system which is rapidly accessed through the intramolecular cycloaddition of cyclobutadiene
Thesis (MS) — Boston College, 2013
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Chemistry
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Salinas, Uber Jorge. "Design and synthesis of photoswitchable coordination complexes." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/399911.
Full textAbstract:
One of the main objectives of this thesis was the synthesis of new chelating ligands containing a photochromic unit able to change its conformation upon light irradiation. This isomerization should serve to modify the magnetic behavior of the new coordination compounds, formed upon reaction of transition metals or lanthanides, assembled within the phtochromic ligands. Whith these aims, the synthesis of 5 new ligands has been achieved, which have been characterized successfully. Subsequently, the preparation of 22 coordination compounds with these ligands has been accomplished. The crystallographic study of these coordination compounds has been very important for the complete understanding of the magnetic and photohromic properties. Regarding the crystal structures, in Chapter 1, the distinct photochromic properties of the complexes discussed was rationalized in light of the structural information. The results show that crystal design may constitute an interesting way for modulating the properties of the solid state photoactivity. Two new ligands were synthesized in Chapter 3, based on beta diketone moieties, which additionally, are functionalized with a phenol group. Those groups together form an excellent chelating pocket to introduce metal arrays. Importantly, those arrays can be formed as pair of heterometallic dimers, whose ground state exhibit in some cases S=1/2 systems, thus providing a pair of spins ½ well defined within the molecule. This feature can be exploited in the context of quantum computing by studying the quantum coherence of these spin. Indeed, coherence times of thousands of nanosecond can be measured at low temperature.. Two other new ligands, have been presented in Chapter 4. These have been synthesized via Schiff base condensation. Similar two the beta diketones, these ligands are able to perform fast and excellent photochromism, in addition to the cis/trans isomerizations that can undergo themselves. While those isomerizations have not been studied, they could be used as gate-reactivity, adding more versatility to these compounds. The chelating pockets of these ligands are very useful regarding to the coordination ability with lanthanides and transition metals. Single molecule magnet behavior has been observed in a dysprosium cluster. Finally, in Chaper 5, the synthesis of a new photochromic ligand containing a pyridine-pyrazole moiety, has been tested for the preparation of a Fe(II) spin crossover helical system. This has shown to be a good candiadate as part of new hybrid devices, because the excellent resistance to the fatigue, the different fluorescent behavior and the SCO features.Durante el transcurso de esta tesis, se han sintetizad nuevos ligandos quelantes que contienen una unidad fotocrómica, capaz de cambiar su conformación tras la irradiación de luz. Esta isomerización debe servir para modificar la interacción magnética de los nuevos compuestos de coordinación, basados en los mencionados nuevos ligandos. Se ha logrado la síntesis de 5 nuevos ligandos y la preparación de 22 compuestos de coordinación. El estudio cristalográfico de estos compuestos de coordinación ha sido muy importante para la comprensión completa de las propiedades magnéticas y fotocrómicas. En el Capítulo 2, las propiedades fotocrómicas de distintos complejos fueron racionalizadas a la luz de la información estructural. Los resultados muestran que el diseño previo puede constituir una buena herramienta para la modulación de las propiedades del estado sólido. Dos nuevos ligandos se sintetizaron en el Capítulo 3, basado en dicetonas. Estas matrices pueden formar pares de dímeros heterometálicos, cuyos estados fundamentales, S = ½, sistemas, pueden ser explotados en el contexto de la computación cuántica mediante el estudio de la coherencia cuántica del espín. En el Capítulo 4, otros dos nuevos ligandos fotocrómicos y sus complejos de coordinación con los lantánidos y metales de transición han sido caracterizados con tal de ver su utilidad en el campo de imanes unimoleculares. Finalmente, en el Capítulo 5, la síntesis de un nuevo ligando fotocrómico que contiene un grupo piridina-pirazol, se ha probado para la preparación de un sistema helicoidal de Fe (II) con transición de espín. Este ha demostrado ser un buen candidato como parte de nuevos dispositivos híbridos, debido a la excelente resistencia a la fatiga, el diferente comportamiento fluorescente y su capacidad para producir una transición de espín.