Journal articles on the topic 'Synergism prevailing'

ABSTRACT There has been a prevailing perception that Th1 and Th2 immune responses induce antagonistic immune effector mechanisms during an infection. We investigated the role of the Th1 cytokine gamma interferon (IFN-γ) and the Th2 cytokine interleukin-5 (IL-5) in murine filariasis infections with the rodent filarial nematode Litomosoides sigmodontis with regard to immune responses to the parasite. Earlier data showed an important role for IL-5 and IFN-γ in effective immune responses to filarial infection. Therefore, in this study it was asked whether IL-5 and IFN-γ act synergistically or antagonistically. Indeed, IL-5 as well as IFN-γ knockout (KO) mice show a higher worm load than the wild-type controls. IFN-γ/IL-5 double-KO mice had a significantly higher worm load than any of the single-KO mice, suggesting a synergism between IFN-γ and IL-5 in controlling worm infection. Neutrophils are known to play an important role for the containment and encapsulation process of the worms. In infected IFN-γ KO, IL-5 KO, and IFN-γ/IL-5 double-KO mice, neutrophils were significantly reduced in chemotactic activity levels compared to controls. In addition, the level of phagocytosis activity of neutrophils from IFN-γ/IL-5 double-KO mice was further decreased in comparison to that of the single-KO mice. Levels of tumor necrosis factor alpha, which is an important factor for neutrophil activation, were found to be reduced in macrophages from KO mice. In conclusion, these results argue for immune effector mechanisms in murine filarial infection that are dependent on both IFN-γ and IL-5. Synergistic effects of the two cytokines may be mediated, at least in part, by neutrophils for the control of adult worms.

Eating behaviors arise from a combination of several factors namely, physiological, emotional, social and genetic, including the prevailing state of the environment that the individual has been exposed to from the commencement of development. Several factors are known to affect the control of eating behaviors, distinguishable by the synergism of the homeostatic and hedonic control mechanisms, which are complementary. While undeniably homeostasis is under the control of the hormonal interchange between the intestine and the brain, the desire to eat is focused on the brain reward system, which includes acquisition and addictions and binge eating. In today's world, the easy availability of processed foods, high in sugars and fats, which stimulate the reward areas, can flood the brain with neurotransmitters linked to pleasure and happiness. This often results in an uncontrollable desire to eat, technically termed hedonic hunger. A presentation of an integrated perspective of the mechanisms involved in the control of hedonic eating behavior is given. It is crucial to understand these mechanisms, particularly paying attention to the ways the modern food environment induces excessive consumption and its contributions to the present obesity epidemic.

Abstract The negative effect of air pollution on mountain spruce stands culminated in the 70s – 90s of the 20th century, when an extensive dieback and disturbance of stands occurred in the Krkonoše Mts., the Czech Republic. Dendrochronological analysis was used on ten permanent research plots established in 1976–1980 to document the dynamics of radial increment of Norway spruce (Picea abies [L.] Karst.). The objective was to determine the effect of SO2, NOX and O3 concentrations and precipitation and temperatures on spruce radial growth in climax forests, waterlogged forests and cultivated forests. The results document the strong depression of diameter increment in the period 1979–1991 caused by synergism of climatic extremes and high SO2 pollution in the 80s and 90s of the 20th century. After 2000 climate had prevailing effect on radial growth. Spruce increment was in positive correlation with temperature, particularly with temperature in the growing season and annual temperature of the current year. In general, temperature had a more significant effect on increment than precipitation, mainly in climax and peaty spruce stands. Diameter increment was in significant negative correlation with SO2 and NOX concentrations in all types of stands. Overall, peaty spruce stands were the most vulnerable to air pollution stress. Low radial increments were caused also by climate extremes, historically by strong frosts and winter desiccation in early spring, nowadays in time of climatic changes by extreme drought. Spruce stands have the ability of quickly responding by tree-ring width to both negative and positive impulses related with air pollution and climate.

Designing appropriate policies and strategies that lead to environmental conservation (of biological diversity and natural ecosystems) and ecologically sustainable development, is not an option but a necessity. Nevertheless, it requires an appropriate developmental paradigm that can provide a more relevant perceptual and interpretive framework from which such strategies may emerge. The prevailing dominant social paradigm has ignored the following problems: the present level of resource consumption in the developed industrialized countries, the acute poverty and inequitable development pattern in the Third World, the massive capital flight from ‘global’ South to ‘global’ North, and the massive population growth-rates in poor Third World countries, for political or ideological reasons. This paradigm will ultimately lead to environmental destruction and collapse of The Biosphere if ‘business’ continues ‘as usual’.There has been unwillingness on the part of the politicians to admit this truth, but the development philosophy that does not include the strategies which can induce changes in our consumption and behavioural patterns, attitudes towards Nature, environmentally sound conservation and management practices and principles, elimination of poverty and inequity, and reduction of global population growth, will achieve nothing more than, as Morowitz (1991) calls it, a ‘Sisyphus's Myth’.Only a development paradigm that is deeply rooted in the principle of cooperation, social synergism, equity, and the understanding of ecological and social sustainability of resource uses, allocation, and management, can offer hope and engender optimism. The sooner humanity realizes and acts on this, the greater will be the chance for environmental conservation and the lesser will be the cost of human adaptation.

Cover cropping reduces soil erosion mainly by providing cover when the soil is left barren after a short season crop. It also improves nutrient cycling and prevents the loss of NO3-N by leaching especially during late fall and early spring season. When CCs are grown in a sequence, they are able to harvest both the benefits mentioned above and provide ecological services. However, there may be synergistic or antagonistic effects in action between CCs just as is the case of CC allelopathy in weed control. Field experiments were conducted over two cropping seasons (2016-16 and 2016-17) at Michael Fields Agricultural Institute, Wisconsin on a forest derived Fox silt loam (Fine-loamy, mixed, mesic Typic Hapludalfs) under organic certification to determine the effect of sequential planting of CCs on Above Ground Biomass (AGB) yield, N and C addition and to determine the synergistic or antagonistic effect of the species grown in a sequence on each other. Ten different species of CCs were planted immediately after crop harvest in early August followed by winter rye in a sequence, after roll-crimping of the first cover. The cropping sequences significantly affected the cover crop yield and related parameters. Radish – winter rye sequence was the best performing one in both years of study with regard to the AGB yield (13.96 and 14.87 Mg ha-1 respectively), and large amounts of N and C added to the soil. Phacelia – winter rye followed close, with the sequence recording on par yields in 2015-16 (13.28 Mg ha-1). Winter rye performed better following a dicot compared to monocot; non-legume compared to a legume. The CC sequences also exhibited synergism and antagonism. The yield of winter rye was boosted when the biomass yield of the forage radish it followed increased, which we consider as synergy: while the yield of winter rye reduced whenever the yield of oat, barley or beseem clover it followed increased, which we consider as an antagonistic effect. The other CCs performed moderately and were greatly a reflection of the prevailing weather conditions. More research along this line is recommended to generate research based information on synergy and antagonism in CC sequence.

In the face of rapid urbanization and global climate change, understanding the trade-offs and synergies of wetland city ecosystem services is vital for mitigating regional ecological and environmental risks, and enhancing human well-being. The Dongting Lake Basin is an ecologically fragile area of global significance. Uncontrolled resource utilization and intensive human activities have severely damaged the ecological environment, including in Miluo. Thus, it is of paramount research importance to uncover the trade-offs and synergies of ecosystem services and their driving mechanisms in Miluo. To achieve this, we classified Miluo’s land use data over the past two decades using a random forest model and Landsat imagery. We quantified the major ecosystem services in Miluo by employing ecological process models such as InVEST, RUSLE, and CASA. Additionally, we examined the trade-offs and synergies between ecosystem services at different scales and identified the driving mechanisms using multi-source remote sensing data. The results revealed that forests exhibited the highest level of ecosystem services, while urban ecosystem services experienced a significant decline. Over the past two decades, Miluo displayed notable trade-offs and synergies between ecosystem services, with synergies prevailing as the dominant pattern, particularly at the county scale. Furthermore, human activities emerged as the primary driver of changes in Miluo’s ecosystem services during the 20-year period. Therefore, it is imperative for scientists, policymakers, and civil society to develop effective and scientifically sound strategies to mitigate the ecological risks resulting from rapid urbanization and climate change in the future.

PurposeThe present study proposes a model to examine the cultural fit between buyers and suppliers for establishing synergies in their processes and practices.Design/methodology/approachThis study assessed buyers' culture through the Competing Values Framework and used Quality Management Practices Model as a proxy to assess suppliers' culture. The data from 262 paired respondents were used for this analysis. This survey was administered in India, using linear snowball-sampling technique. This study applied 3SLS regression for each culture group separately.FindingsThis study has instituted the cultural fit between the buyers' and suppliers' culture. It is observed that for getting synergies between cultures, buyers need to choose a set of suppliers which have similar cultural traits.Research limitations/implicationsThis study presents empirical findings based on data from Indian manufacturing firms. These findings need testing in other developing countries and other sectors.Practical implicationsOrganizations can formulate right policies for supplier selection based on the cultural fit between buyers and suppliers.Originality/valueWith increasing role of suppliers in the value chain, organizations around the world need to work with the right suppliers for gaining a sustainable competitive advantage. Selection of the right suppliers depends on the cultural fit between buyers and suppliers that, in turn, depends on the selection of the right suppliers based on the prevailing culture.

Vitiligo is a cutaneous disorder of depigmentation, clinically characterized by well-demarcated, white macules of varying size and distribution. It can affect up to 2% of the population, especially younger ages. In spite of recent findings implicating genetic, immune and oxidative stress factors, the exact pathogenesis of vitiligo remains obscure. Here, we briefly discuss the prevailing theories, and offer new suggestions that could explain in part the damage of melanocyte in the vitiliginous lesions. Our emerging hypothesis is that neuropeptides released from peripheral nerve endings could synergize with new cytokines to adversely affect melanocyte function and viability. These may include corticotropin-releasing hormone (CRH) and neurotensin (NT), as well as interleukin 33 (IL-33) and thymic stromal lymphopoietin (TSLP). Such interactions could serve the basis for further research, possibly leading to new treatments.

Abstract This article explores synergies between Hungarian critical sociology in the 1960–70s and the documentary films made in Balázs Béla Stúdió in the same period. It treats the rationalization of social phenomena as a battle ground for meaning and claims that both representatives of the social sciences and filmmakers, on the one hand, called upon deficient social mechanisms and the inner contradictions of existing socialism and, on the other hand, pointed to the discrepancy between ideological and empirical perceptions of reality as the root cause of the crisis characterizing the consolidated Kádár regime. Adopting Clifford Geertz’s conceptual matrix of the experience-near and the experience-distant production of social meaningfulness, the article explores how sociologists and makers of sociographic documentaries alike resisted the prevailing epistemic regime, more specifically how they punctured and undermined the ideological meanings of such concepts as maternity, the Romani, and cooperative democracy.1

This discussion focuses upon the ways in which early modern and modern cultural debate examines memory both in terms of its functions and nature as human faculty and of its effects as a cultural phenomenon. It seeks to uncover some of the striking synergies as well as the contrary motions in the vigorous cultural debates surrounding the reflex to remember and its implications for various target audiences. Of particular interest will be the ways in which memory was and is pressed into service to forge critical narratives of origin and belonging at both a personal and collective level, notably with reference to Shakespeare’s history plays. Discussion ranges across a number of early modern textual genres (e.g. correspondence, drama, epic poetry, historiography, devotional writing) to probe the prevailing cultural expectations surrounding the exercise of recollection and the consequences of the failure to perform such duties.

This article explores the compatibility of Ghana’s e-waste policy (Act 917) in the country’s socioeconomic context. Our article starts with two main questions based on our empirical engagements with the act which, contextually, mimics the extended producer responsibility. First, we question the pessimistic imaginaries about the e-waste industry that seeks its outright trade ban or promotes a single version of recycling. Second, we query if the underlying assumptions and basic mechanisms of extended producer responsibility can create the enabling environment to actualize sound e-waste management. Based on prevailing context, the imaginaries appear socially peripheral, isolated, and powerless, and we call for a broader, unbiased, in-depth, critical systems thinking for understanding the complexities and multidimensional nature of the waste electrical and electronic equipment industry. We suggest that it is by fostering the positive synergies across sectors and among policies that environmentally sound e-waste policy outcomes can be achievable.

Abstract Fire-induced and stress-driven catastrophic failures in rock and concrete are commonly known as spalling (or rockburst in its severe form) that have jeopardised the safety of personnel, seriously damaged rock structures, and shut down operations for months or even permanently in certain circumstances. Particularly in Australia, spalling and rockburst in deep excavations results in a heavy toll on mine safety and have become a constraint to the economic viability of several Australian deep mines since the early 1950s. The prevailing industry approach is to treat such unwanted failures and associated microseismic events as a result of insufficient energy absorption by the spalling-prone rock/concrete at the post-peak stage. However, this approach does not allow efficient handling of heat- or stress-induced failures as it requires an in-depth understanding of their mechanics. Prediction of these events based on the available failure criteria does not help either due to the numerous criteria involved and the difficulty in determining their parameters at the excavation scale. A proper understanding of the fracture growth in such failures is needed to understand the behaviour of rock or concrete structures resulting in a sudden release of energy at deep excavations. This paper investigates the similarities and differences between heat-induced concrete spalling and stress-driven rockburst and further examines the effect(s) of material, geometrical, geological properties, and the applied deviatoric stresses on these failure modes.

SUMMARYPayments for environmental services (PES) have been recognized as a promising mechanism for conservation, with the potential to contribute to social objectives such as poverty reduction. This paper outlines a simple framework for assessing the potential for synergies in the implementation of PES programmes, used to analyse the new watershed conservation funding (WCF) channelled through Costa Rica's national PES programme, Pago por Servicios Ambientales (PSA). The WCF financing can only be used in a limited number of watersheds. Given this constraint, the paper examines the mechanisms by which the WCF may potentially contribute to biodiversity conservation and to reducing social development gaps. Although there is significant spatial correlation among the priority areas targeted for the objectives of watershed conservation, biodiversity conservation and social development, the availability of the WCF per unit of land in most watersheds is limited compared to the PSA programme's prevailing payment rate of US$ 64 ha−1, potentially hindering the impact of the WCF on conservation and social development. The analysis helps guide the allocation of the PSA budget in a way that complements the WCF and improves the cost-effectiveness of the PSA budget.

ABSTRACT Repeated evidence has demonstrated that combined primer-booster immunization regimens can improve both secreted and humoral immune responses to antigens derived from viral, bacterial, and parasitic pathogens. For the present work, we evaluated the synergic serum immunoglobulin G (IgG) and fecal IgA antibody responses elicited in BALB/c mice who were intramuscularly primed with a DNA vaccine, pRECFA, followed by oral boosting with an attenuated Salmonella enterica serovar Typhimurium vaccine (HG3) strain, with both vaccines encoding the structural subunit (CfaB) of the CFA/I fimbriae produced by human-derived enterotoxigenic Escherichia coli (ETEC) strains. The immunological properties of the vaccine regimen were evaluated according to the order of the administered vaccines, the nature of the oral antigen carrier, the age of the vaccinated animals, the interval between the priming and boosting doses, and the amount of injected DNA. The production of gamma interferon and the IgG2a subclass in serum indicated that mice immunized with the primer-booster regimen developed prevailing type 1 T-cell-dependent immune responses. The synergic effect of the vaccine regimen on the induced antibody responses was also revealed by its ability to block the adhesive properties of CFA/I fimbriae expressed by live bacteria, as shown by the inhibition of Caco-2 cell and human erythrocyte binding. Moreover, DBA2 newborn mice were protected from lethal challenges with a CFA/I+ ETEC strain after the incubation of live bacteria with serum samples harvested from mice who were subjected to the primer-booster regimen. We propose, therefore, that the DNA primer-Salmonella booster regimen represents an alternative for the development of vaccines requiring both mucosal and systemic antibody responses for immunological protection.

Abstract The Baltic fisheries are in distress. In the Central Baltic, fisheries management is challenged by reduced cod stock productivity, and altered species interactions. Here, we use an age-structured, ecological–economic multispecies model, which includes latest biological and economic knowledge, to advance our understanding of optimal fisheries management and related trade-offs between user groups under such altered conditions. We contribute to the scientific discussion (i) by showing that the economic importance and optimal stock size of cod largely decreased under prevailing conditions, while clupeids increased in importance. (ii) We challenge the current MSY management objective in a multispecies setting (MMSY) and suggest that an economic multispecies management objective (MMEY) might be more useful for setting future management targets. (iii) We identify new trade-offs and synergies by including a consumer perspective: There is a win–win situation for ecological conservation, and profits in the fishery, while fishery management faces trade-offs between these two on the one hand, and consumer surplus on the other hand. (iv) Finally, we suggest an easy to implement new management approach, called robust management, which is capable of better dealing with variability and time-trends in recruitment, as observed for cod, in order to safeguard the Central Baltic fishery resources.

Existing theoretical interpretations contend that modernization is a global but diverse and multidimensional process. Yet, a systematic analysis of multiple forms of modernity and modernization ‘is the major challenge to current social and political theory’ (Wagner). The paper aims at revealing limitations of current theoretical interpretations of modernization and demonstrating systematically essential features of modernity. I describe the crucial criteria of modernization and suggest an integrated approach within which the most influential theories are simultaneously applied as coherent explanations. Such a synergic application allows identifying concomitant dimensions of modernity and modernization. The proposed approach significantly differs from a prevailing theoretical discourse on modernity and modernization. It demonstrates universal features of modernization along with civilization variability and uniqueness of cultural programs, antinomic emancipation trends, permanence of change and innovations, increase of efficiency, competitiveness and the quality of life. All these dimensions relate to a set of consistent interpretations of a complex multi-effects phenomenon, which minimizes the existing conceptual contradictions. The elaborated model supports the notion of modernization as a continuous transition to novel forms of social order which respond to emerging challenges and global competition while an invariant criterion of modernization is the boost in the capabilities of people to make their choices.

PurposeThere is a dearth of studies exploring the intersection of gender and disability within entrepreneurship research. This is despite women’s entrepreneurship research encouraging an expansion of the research questions asked and approaches taken. As a contribution to this debate, the purpose of this paper is to develop an understanding of gender and disability as social categorizations which can shape entrepreneurial opportunities and experiences for disabled women entrepreneurs.Design/methodology/approachThe paper offers an intersectional conceptual lens for the study of disabled women entrepreneurs to explore a concern for a particular social group – women – at a neglected point of intersection – disability – within the social setting of entrepreneurship. Guided by the research question (how can gender and feminist disability theory contribute to the development of an intersectional theoretical lens for future entrepreneurship research?), the potential for new theoretical insights to emerge in the entrepreneurship field is identified.FindingsThrough a gender and disability intersectional lens for entrepreneurship research, four theoretical synergies between gender and disability research are identified: the economic rationale; flexibility, individualism and meritocracy; and social and human capital. In addition to the theoretical synergies, the paper highlights three theoretical variances: the anomalous body and bodily variation; sexuality, beauty and appearance; and multiple experiences of care as potentially generative areas for women’s entrepreneurship research. The paper identifies new directions for future gender, disability and entrepreneurship research by outlining research questions for each synergy and variance which draw attention to disabled women entrepreneurs’ experiences of choice and control within and across different spaces and processes of entrepreneuring.Originality/valueThe conceptual intersectional lens offered to study disabled women’s entrepreneurship highlights new directions for exploring experiences of entrepreneuring at the intersection of disability and gender. The paper brings disability into view as a social category that should be of concern to feminist entrepreneurship researchers by surfacing different dimensions of experience to those currently explored. Through the new directions outlined, future research can further disrupt the prevailing discourse of individualism and meritocracy that perpetuates success as an individual’s responsibility, and instead offer the potential for richer understandings of entrepreneuring which has a gender and disability consciousness.

Lisbon is a European Mediterranean city, greatly exposed to heatwaves (HW), according to recent trends and climate change prospects. Considering the Atlantic influence, air temperature observations from Lisbon’s mesoscale network are used to investigate the interactions between background weather and the urban thermal signal (UTS) in summer. Days are classified according to the prevailing regional wind direction, and hourly UTS is compared between HW and non-HW conditions. Northern-wind days predominate, revealing greater maximum air temperatures (up to 40 °C) and greater thermal amplitudes (approximately 10 °C), and account for 37 out of 49 HW days; southern-wind days have milder temperatures, and no HWs occur. Results show that the wind direction groups are significantly different. While southern-wind days have minor UTS variations, northern-wind days have a consistent UTS daily cycle: a diurnal urban cooling island (UCI) (often lower than –1.0 °C), a late afternoon peak urban heat island (UHI) (occasionally surpassing 4.0 °C), and a stable nocturnal UHI (1.5 °C median intensity). UHI/UCI intensities are not significantly different between HW and non-HW conditions, although the synoptic influence is noted. Results indicate that, in Lisbon, the UHI intensity does not increase during HW events, although it is significantly affected by wind. As such, local climate change adaptation strategies must be based on scenarios that account for the synergies between potential changes in regional air temperature and wind.

Conventional and emerging paradigms of urbanism require new responses under the current circumstances, especially in relation to the integration of sustainability dimensions and technology advances. The escalating rate of urbanization, coupled with the climate emergency, fundamentally indeed disrupt the challenges that urbanism research and practice deal with, calling for adopting more innovative approaches to urban planning and design. With cities contributing around 65% of Greenhouse Gas (GHG) emissions and experiencing an unprecedented growth of population, contemporary urban policy needs to be redefined and re-assessed accordingly. While numerous urban models, such as the Compact City, the Eco-City, the Sustainable City, and the Smart City, have emerged in response to the challenges of sustainability and urbanization, the 15-Minute City has recently gained a steep popularity. This paper explores the theoretical, practical, and technological foundations of the 15-Minute City, with a particular focus on the proximity dimension of mixed land-use and its environmental, social, and economic benefits of sustainability as supported by smart technologies. We argue that this evolving model of urbanism has the potential to gain more expansion and success in regard to building more sustainable, efficient, resilient, equitable, and inclusive cities in line with the global agendas of Sustainable Development Goal (SDG) 11, as it adds a strategic value to the amalgam of the prevailing and emerging paradigms of urbanism and their synergies with respect to increasing the benefits of sustainability while emphasizing its environmental dimension.

To assess the state and prospects for the development of cancer mapping in Russia, country and world experience in the preparation of cartographic works on cancer topics is useful. For this purpose, an attempt was made to trace the development of cancer mapping on the example of foreign atlas works and some publications on their review. National (Australian Cancer Atlas, Taiwan cancer map, Canadian Cancer Incidence Atlas, etc.) and world (The Cancer Atlas, Global burden of cancer women, Global Atlas of Palliative Care at the End of Life, etc.) atlases are presented. They deserve attention in terms of promoting the content and methodological side of cancer mapping, as well as expanding their functionality. The review of atlases reflects the diversity of approaches to their development, the differences in the indicators used, and the prevailing trends in the presentation of results for solving the problems facing medicine and society. The concept of “burden” is the basis of the concept of a significant part of the atlases. It covers various aspects of the manifestation of cancer (from medical to socio-economic) and is displayed in atlases, depending on their purpose, with varying degrees of completeness. From studying the spatio-temporal spread of cancer, atlas studies are moving on to building and testing hypotheses about the factors and determinants of cancer on the basis of a variety of synergies of natural, social, economic, environmental, behavioral and other features.

This paper models the significance of mergers and acquisitions (M&A) in reviving the growth of obsolete or low performing organizations. In line with adapting to the changing circumstances and limiting exposure to the volatility, higher level of capital backing is necessary which only consolidation can achieve (Mantravadi, 2007). Banks being economic institutions are expected to be more directly involved in inclusive growth by including the whole economy in the growth and development, therefore, to support this belief, merger and acquisition as a strategic tool is studied. M&A is considered as one of the significant tools for organizational restructuring and value addition considering the volatility prevailing in the present business environment. It enables organizations to expand their horizon of operation, mitigating risks, explore new markets and geographical locations by creating synergies thereby increasing profitability gaining through competitive advantage. It includes the study of the factors and series of events that led the Government of India (GOI) to the merger of 10 public sector banks (PSB) into 4 merged entities, adoption of M&A as technique to achieve objectives moreover it studies acquisition of the Allahabad Bank by the Indian Bank to identify and interpret the purpose and potential of consolidation backed by a comparative analysis of pre-acquisition and post-acquisition performance of the above-mentioned banks. Key Words: Mergers and Acquisitions, Public Sector Banking (PSB), Indian Bank, Allahabad Bank, NPA and Synergy.

Prevailing current definitions of science are largely based on a traditional, positivist paradigm that favors the natural sciences and either denies or downplays the scientific status of the social sciences and the humanities. The disciplinary organization and institutionalization of research and systematic inquiry is still the norm. This article argues that the rigid organization of science and indeed the dominant view that there are hard sciences and soft sciences with the latter occupying an inferior position with regard to their knowledge claims and utility is pretty outmoded and does not fit well the current challenges and global needs. This is not just an academic issue but has clear practical implications in terms of funding and staffing, as well as the distribution of other valuable resources, especially in view of the dwindling federal and state funding for both the natural sciences and the humanities and social sciences. We develop our argument using as a methodological platform the ideas of ‘The Two Cultures,’ the ‘Science Wars,’ the new constructivist turn in social studies of science, and science as a social institution. We argue that current definitions of science need to be modified to include the humanities and to emancipate the social sciences and the ‘soft’ paradigms associated with them. This can form the basis of an earnest effort for better integration of different kinds of disciplines and for achieving much needed synergisms to tackle complex problems that tend to be multifaceted and whose solutions do not easily conform to single disciplinary paradigms. The contention here is that such a bridge between the two cultures can use as a model the social sciences, since they successfully combine methods from the natural sciences with approaches and theories common in the humanities. In our opinion, this is a feasible path to both greater interdisciplinarity and more vigorous collaboration between the different branches of science that can benefit both working scientists and society at large when dealing with pressing issues like environmental problems, the depletion of natural resources, pandemics, and natural disasters.

Background Hypereutrophic conditions in major water reservoirs used for irrigation purposes in South Africa promote the co-existence of cyanotoxins and other pollutants such as linear alkylbenzene sulfonate (LAS). LAS is known to alter the permeability of membranes and promote the uptake of other pollutants by plants. In light of the potential human health risks and prevailing hypereutrophic conditions in some catchments in South Africa, we investigated the combined effects of LAS and microcystins (MCs) when cyanobacteria infested water is used to irrigate terrestrial crops. Methods To understand the potential risks, pot-culture experiments were conducted to assess the effect of LAS on the accumulation of MCs in Brassica oleracea (cabbage) and Solanum tuberosum (potato) plants. The plants were watered with dam water containing 3.48 mg L-1 of the LAS (sodium dodecyl sulfate) and MCs (MC-LR: 10.47 ± 3.879; 6.158 ± 4.127 for MC-RR and 8.160 ± 2.544 for MC-YR μg L-1) for 20 days. Results The presence of LAS, at environmentally relevant concentrations in the irrigation water, did not enhance the uptake of MCs in the two plants, as demonstrated by statistically insignificant differences in the means of the treatments (with and without LAS). In addition, the presence of LAS, high pH, electrical conductivity (EC), and cyanotoxins in the water did not affect the total chlorophyll or the well-being of the plants. However, in some cases the levels of MCs bioaccumulated by the two plants exceeded the WHO recommended tolerable daily intake (TDI). Conclusions These findings imply that the tested levels of LAS and MCs did not have any synergic effects on the two plant species, but irrigating food crops with such water still poses a human health risk.

Background Globally, hypereutrophic conditions in major water reservoirs used for irrigation purposes, promote the co-existence of cyanotoxins and other pollutants such as linear alkylbenzene sulfonate (LAS). LAS is known to alter the permeability of membranes and promote the uptake of other pollutants by plants. In light of the potential human health risks and prevailing hypereutrophic conditions in some catchments in South Africa, we investigated the combined effects of LAS and microcystins (MCs) on food plants when cyanobacteria infested water is used to irrigate terrestrial crops. Methods To understand the potential risks, pot-culture experiments were conducted to assess the effect of LAS on the accumulation of MCs in Brassica oleracea (cabbage) and Solanum tuberosum (potato) plants. The plants were watered with dam water containing 3.48 mg L-1 of the LAS (sodium dodecyl sulfate) and MCs (MC-LR: 10.47 ± 3.879; 6.158 ± 4.127 for MC-RR and 8.160 ± 2.544 for MC-YR μg L-1) for 20 days. Results The presence of LAS, at environmentally relevant concentrations in the irrigation water, did not enhance the uptake of MCs in the two plants, as demonstrated by statistically insignificant differences in the means of the treatments (with and without LAS). In addition, the presence of LAS, high pH, electrical conductivity (EC), and cyanotoxins in the water did not affect the total chlorophyll or the well-being of the plants. However, in some cases the levels of MCs bioaccumulated by the two plants exceeded the WHO recommended tolerable daily intake (TDI). Conclusions These findings imply that the tested levels of LAS and MCs did not have any synergic effects on the two plant species, but irrigating food crops with such water still poses a human health risk.

Purpose This study aims to present an empirical model related to strategic performance (SP) of the hospitality industry. It focuses on the role of network capability (NC) in defining SP through the mediating role of structural flexibility (SF). Furthermore, the interaction effect of NC and top management commitment to strategic performance (MCSP) on SP is also tested. Design/methodology/approach A sample of 279 managerial-level employees of four-star and five-star hotels has been used to confirm the proposed hypotheses by using the technique of structural equation modeling. Findings The results reveal that NC positively affects SP. Moreover, the mediating role of SF in defining the nexus of NC and SP has also been confirmed. Results of moderation analysis reveal that MCSP strengthens the relationship between NC and SP. Research limitations/implications This study used a cross-sectional design for data collection, which prevents strong causal inferences. The authors recommend scholars to explicitly test for causal effect. This study used a cross-sectional design for data collection, which prevents strong causal inferences. The authors recommend scholars to explicitly test for causal effect among all these variables by using a longitudinal study in the future. Practical implications In developing countries, it has been observed that the hospitality industry pays less attention to its strategic targets. Operating in a network or adapting flexible structures is also not on their priority list. This study presents a pragmatic approach based on strong theoretical grounds to attain the goals of SP in the hospitality industry through NC and SF. Therefore, this study suggests that organization operating in the tourism and hospitality industry should pay greater attention toward synergies and business networks to achieve SP. Originality/value This research enriches the prevailing knowledge by testing a mediating role of SF between NC-SP link and, therefore, makes an important addition to the existing knowledge on tourism and hospitality industry by concentrating on the relationship between NC, SF, MCSP and SP.

The changing role of small towns is a noticeable topic of contemporary research on urban and regional development in Poland. Unlike those situated within the zone of daily commuting around large cities, small urban localities in what are peripheral localities from the point of view of Poland as a whole are strongly exposed to metropolitan development backwash effects, which manifest themselves in migration outflow and population ageing, together with the loss of certain specialised functions that tend to cluster in centres at higher levels in the urban hierarchy. Going against these general trends, some of the towns in question are in a position to maintain existing activities in manufacturing or service branches of international or national market range, and/or to attract new ones. At the same time, those small urban localities that witness a curtailment of more-specialised functions experience a growing reliance on the public sector, in addition to commercial activities of local range, performing a stabilising role with regard to urban-rural functional relations at the local level of the settlement system. This article focuses on factors that underpin such polarisation trends by referring to the concepts of territorial competitiveness and territorial capital (Camagni, 2002, 2008). It illustrates their applicability using materials derived from an empirical study covering a subset of 19 small towns, of populations between 3000 and 10,000, situated in environmentally rich North-Eastern regions of Poland. Aiming to acquire primary data, the study has involved a series of extended, open-ended interviews with local stakeholders (5 to 7 per town), together with a questionnaire-based survey of 55 enterprises, in manufacturing and services of supra-local market range. As the results show (in line with the assumptions of Camagni), successful development of specialised functions, including niche-type activities in the small towns under study, can in several cases at least be linked to synergic effects between such components of territorial capital as creativity, local entrepreneurship and proactive policy on the part of local government. By focusing on the (EU Structural Fund-supported) extension and modernisation, of technical as well as social infrastructure, the latter have contributed to a general improvement in living conditions locally over the last fifteen years. This has in turn created some potential for attracting new residents, first of all from the surrounding rural areas; and – as a more distant prospect – also returning migrants from both abroad and other localities (typically Poland’s large urban centres). Thus, even in the face of prevailing depopulation trends, the small towns presented here (including local service centres) may enjoy certain opportunities to expand their place-of residence functions of both local and supra-local scope.

En América Latina, la intensificación de los sistemas agrícolas y las consecuencias sociales y ambientales derivadas del proceso, han generado cuestionamientos respecto del modelo productivo imperante. En Argentina, la región pampeana ha sido escenario de este proceso. Sin embargo, en el sudeste bonaerense en general y en el partido de General Pueyrredon en particular, adquieren relevancia los sistemas con bases agroecológicas que emergen recientemente en zonas de transición urbano-rural, con mayor énfasis en la agricultura intensiva y, en menor medida en la extensiva. En este contexto, surge el interés de avanzar en la evaluación del desempeño de los sistemas con bases agroecológicas del partido de General Pueyrredon. Para ello, se ha comenzado a trabajar con experiencias hortícolas. En la primera etapa de la evaluación, se encuentra el desafío de caracterizar la transición agroecológica de sistemas hortícolas del Partido, que es el objetivo principal del presente trabajo. Mediante la aplicación de la metodología TAPE (FAO, 2019) que integra los 10 elementos de la agroecología, se presentan los resultados obtenidos de seis experiencias. Se evidencian situaciones diferenciales en el proceso de transición. En promedio, los elementos de creación conjunta e intercambio de conocimiento y economía circular, reflejan las mejores condiciones. En el otro extremo, se encuentran las sinergias y el reciclaje. El acceso a la tierra, la disponibilidad de capital y la capacidad de gestión, inciden fuertemente en el proceso. La evaluación del desempeño de los sistemas permite obtener un diagnóstico útil para formular políticas. Se considera que incluir la mirada de los actores en etapas iniciales de la evaluación permitiría consensuar los criterios más adecuados para la realidad socio-históricamente situada que permita avanzar hacia la sustentabilidad del territorio local. ABSTRACT In Latin America, agricultural systems intensification and the social and environmental consequences derived from this process have raised questions about the prevailing production model. In Argentina, the Pampas region has been the scene of this process. However, in the southeast of the Buenos Aires province in general and in the district of General Pueyrredon in particular, systems with agroecological bases acquire relevance. These systems have recently emerged in urban-rural transition zones, especially in intensive agriculture and, to a lesser extent, in extensive agriculture. In this context, the interest arises to advance in the evaluation of the performance of the systems with agroecological bases of the district of General Pueyrredon. To do this, work has begun with horticultural experiences. In the first stage of the evaluation, there is the challenge of characterizing the agroecological transition of horticultural systems, which is the main objective of this research. Through the application of the TAPE methodology (FAO, 2019) that integrates the 10 elements of agroecology, the results obtained from six experiences are presented. Differential situations are evident in the transition process. On average, the elements of joint creation and exchange of knowledge and circular economy reflect the best conditions. At the other extreme are synergies and recycling. Access to land, availability of capital and management capacity strongly influence the process. The evaluation of the performance of the systems allows obtaining a useful diagnosis for formulating policies. It is considered that including the gaze of the actors in the initial stages of the evaluation would allow a consensus on the most appropriate criteria for the socio-historically situated reality that allows progress towards the sustainability of the local territory.

Plants coordinate the polarity of hundreds of cells during vein formation, but how they do so is unclear. The prevailing hypothesis proposes that GNOM, a regulator of membrane trafficking, positions PIN-FORMED auxin transporters to the correct side of the plasma membrane; the resulting cell-to-cell, polar transport of auxin would coordinate tissue cell polarity and induce vein formation. Contrary to predictions of the hypothesis, we find that vein formation occurs in the absence of PIN-FORMED or any other intercellular auxin-transporter; that the residual auxin-transport-independent vein-patterning activity relies on auxin signaling; and that a GNOM-dependent signal acts upstream of both auxin transport and signaling to coordinate tissue cell polarity and induce vein formation. Our results reveal synergism between auxin transport and signaling, and their unsuspected control by GNOM in the coordination of tissue cell polarity during vein patterning, one of the most informative expressions of tissue cell polarization in plants.

The relationship between ethical norms and legal norms is different for experts, especially concerning their position. Moreover, legal norms seem to be superior to ethical norms. This study aims to analyze the position of ethical norms and legal norms. The dignified justice theory was chosen because it seeks to orient the divine and human aspects, which can only be fulfilled if ethical and legal norms synergize. This research is juridical-normative research. The juridical-normative research was chosen because it confirms the existence of ethical norms and legal norms as part of the system of norms prevailing in society. The study's results confirm that, in practice, legal court decisions are often considered higher and more authoritative than ethical court decisions. This has implications for the position of ethical norms that are considered inferior to legal norms. Furthermore, the theory of dignified justice seeks to see the relationship between ethical norms and legal norms as different norms, but in its implementation in society, the two norms must synergize and complement each other.

The three cases (Case A: JSW Steel's Ispat Acquisition: The Opportunity; Case B: JSW Steel's Ispat Acqusition: The Setback & Case C: JSW Steel's Ispat Acquisition: The Turnaround Strategy) describe the business situation leading to acquisition of Ispat by JSW, the acquirer company's failure to realize synergies post-acquisition, and the subsequent turnaround initiatives to salvage the situation. In 2010, JSW Steel, a 14 mtpa Indian steel company acquired Ispat Steel with annual production capacity of 3 mtpa. The acquisition was part of JSW's multipronged strategy to realize its aspiration of being a 40 mtpa firm. At the time of acquisition, Ispat had huge debts, a long pipeline of unfinished projects, high production costs and unpredictable cash flows. Its main plant, Dolvi was shutdown for 45 days. However, the plant also had numerous advantages. It was located near the seashore and was technologically very advanced. Case A describes the events leading to acquisition of Ispat by JSW. It captures the facts, opinions and inferences around the acquisition decision, which were used as inputs in the due diligence process to assess synergies between JSW and Ispat. The case describes the economic, competitive, and industry factors prevailing in 2010 when JSW was thinking of acquiring Ispat.

Mergers and acquisitions (M&A) are inorganic growth strategies which have their importance in the present corporate world because of the prevailing stringent business conditions. In the current globalised economy, M&As are progressively utilised for enhancing the intensity of pharmaceutical firms through the rise of their market share in the industry, widening of product portfolio to enter new markets and geographies (competitive advantage) and reaping benefits through enhanced economies of scale. A strong and developing domestic market, a substantial pipeline of generic medicines and a capacity to service established markets abroad have swiftly made the Indian pharmaceutical companies most sought-after in the M&A space. This paper analyses the performance of M&A activities in the pharmaceutical space in India. It aims to consider the pattern in M&A across pharmaceutical companies in India, especially during the period 2005–2017 through a premerger and post-merger analysis. The paper performs a pre and post-merger comparison of 4 most crucial M&A deals in the Indian pharmaceutical landscape through metrics like ratio analysis, share price performance (accretion or dilution in case of listed companies) and synergy benefits from the point of view of the target as well as the acquirer and the combined entity as a whole.

PurposeThis paper aims to address the question: What is the distribution of value (in pounds) created in a sample of domestic takeovers in the United Kingdom from 2013 to 2020 among acquirer and target stockholders?Design/methodology/approachThe author employs a traditional event study methodology to calculate the percentage excess returns of companies on the announcement date. These returns are then converted into pound-denominated excess returns using the companies' market capitalizations. This allows the author to estimate the synergies of the mergers and acquisitions (M&As) and how they are allocated between acquirers and targets. This innovative transformation from percentage to pound excess returns establishes a new ratio methodology for addressing the paper's objective.FindingsThis paper reveals that in UK takeovers, 40 percent of the synergies in pounds are allocated to the stockholders of acquiring companies, while 60 percent go to the stockholders of target companies. In other words, acquirers retain a significant portion—more than half—of the synergies generated in these domestic deals. This original finding is statistically significant at the one percent level and strongly contradicts the hypothesis that acquirers, at best, merely break even.Originality/valueThe evidence that UK takeovers distribute value gains nearly equally between domestic deal parties challenges the enduring conventional insight in the M&A literature. This conventional wisdom suggests that the value created by business combinations is entirely distributed to target company stockholders. Consequently, this reexamination may have broader implications, offering an alternative perspective on the motives behind business combinations. This perspective differs from the “managerial hubris hypothesis,” which aligns with the prevailing conventional insight but receives limited support in the original finding reported here.

A knowledge-based economy adds innovation as another dynamic to a political economy. Whereas a political economy is institutionalized -for example, in a nation state- the knowledge base is volatile although it leaves footprints behind by transforming the institutional layers. This transformation into new options can be measured as redundancy using the Triple-Helix indicator. The balance between historical entropy generation and the knowledge-based generation of options can be measured in terms of positive and negative contributions to the prevailing uncertainty. At what scale and in which sectors is synergy among geographical, technological, and organizational distributions of firms evident? Using mutual information in the three dimensions as an indicator, we analyse a dataset of more than 16 million firms in Brazil and compute synergy within and across states and sectors in this country in terms of bits of information. The results suggest that no synergy is generated at the national level. The political economy of the country has not (yet) been transformed into a national innovation system. At state level, synergies vary according to geographical levels and sectors due to the specifics of the states. Above-average values were found for some states in the South and Southeast Regions. Also, the political capital, Brasilia, has resulted to have no impact in the innovation system of Brazil.

Using terrorist attacks as an exogenous shock to uncertainty, we provide evidence that firms located near terrorism-stricken areas are less likely takeover targets for two years after the attack and receive lower acquisition premiums. The latter finding is reflected in lower target firm abnormal returns and synergy gains. Additionally, in terrorism-stricken areas, target firms are associated with a lower share of synergies, withdrawn deals rise, and acquirers are more likely to get involved in acquisitions of target firms located in different metropolitan statistical areas than their own or acquire faraway target firms. We attribute our results to the real options theory, which predicts that high uncertainty increases the value of the option to delay investments. Additionally, we show that the impact on target firm human capital and acquirer CEO uncertainty and fear are potential sources of terrorism-induced uncertainty with the former source prevailing over the latter. This paper was accepted by Gustavo Manso, finance.

The evolution of scientific advances has often been characterized by the amalgamation of two or more technologies. With respect to vehicle connectivity and automation, recent literature suggests that these two emerging transportation technologies can and will jointly and profoundly shape the future of transportation. However, it is not certain how the individual and synergistic benefits to be earned from these technologies is related to their prevailing levels of development. As such, it may be considered useful to revisit the primary concepts of automation and connectivity, and to identify any current and expected future synergies between them. Doing this can help generate knowledge that could be used to justify investments related to transportation systems connectivity and automation. In this discussion paper, we attempt to address some of these issues. The paper first reviews the technological concepts of systems automation and systems connectivity, and how they prospectively, from an individual and collective perspective, impact road transportation efficiency and safety. The paper also discusses the separate and common benefits of connectivity and automation, and their possible holistic effects in terms of these benefits where they overlap. The paper suggests that at the current time, the sibling relationship seems to be lopsided: vehicle connectivity has immense potential to enhance vehicle automation. Automation, on the other hand, may not significantly promote vehicle connectivity directly, at least not in the short term but possibly in the long term. The paper argues that future trends regarding market adoption of these two technologies and their relative pace of advancement or regulation, will shape the future synergies between them.

AbstractWidespread integration of carbon‐based membranes into prevailing fields like energy storage and material engineering is thwarted by a lack of functionality, customization, and compatibility, making the development of such carbon‐based membranes urgency yet challenging. Herein, a “graphene bubble bridging” strategy is adopted to fabricate the multifunctional carbon fiber membrane, in which graphene bubbles with optimized assembling not only endow the carbon fiber with superior flexibility and integrity by embedded bridging function, but also enhance the fast electron transport capability and electrolyte wettability. Few‐layer MoSSe nanosheets with expanded interlayer spacing as a typical energy storage material contribute to plentiful ion intercalation/deintercalation that can be well buffered within the robust fibers. The interlaced carbon fibers enable a self‐supporting framework that ensures good conductivity and mechanical stability as well. Such functional, customized, and compatible membranes with synergies can boost the attributes of advanced K+ storage devices, such as flexible K‐ion capacitors and K‐based dual‐ion batteries. This work can afford new insights for designing flexible electrode in the energy storage field, as well as various types of conformations that can bring more opportunities on developing flexible functional membranes for other fields (e.g., catalysts, electromagnetic shielding).

Concerns over the capacity of the world’s existing agricultural land to provide food for the global population under climate change and continued biodiversity loss have set the stage for a prevailing narrative of inherent tradeoffs with agricultural production. Coffee, a major export of tropical countries, offers a unique opportunity to examine how different management practices can lead to a variety of outcomes in food security, ecosystem services, and biodiversity conservation. Our study examined this intersection to identify tradeoffs and synergies using compiled data from Puerto Rico. At the island level, we analyzed data on coffee yield and planted area under shade or sun management. At the farm level, we analyzed management variables (percent shade cover, maximum canopy height, ground cover, and food crop richness), non-provisioning ecosystem services variables (total farm carbon storage, soil organic carbon storage, coffee plant carbon biomass, and hurricane resistance and resilience), and biodiversity variables (ant, bird, and lizard richness and abundance). At the island level, we found that planted area was the most significant predictor of total production, suggesting no obvious tradeoff between production and shade management in coffee farms. At the farm level, canopy cover of shade trees was negatively correlated with ground cover and positively correlated with food crop richness, suggesting a synergy between agroforestry and subsistence food production. We detected mostly synergies associated with ecosystem services, biodiversity conservation, and agroforestry management and no tradeoffs among ecosystem service and biodiversity parameters. Shade canopy cover significantly increased total carbon storage, coffee plant biomass, hurricane resistance, and bird species richness. Shade canopy height had a similar positive effect on total farm carbon storage while food crop richness had a positive effect on farm resilience following Hurricane Maria. Ground cover was positively associated with soil carbon storage and pest-controlling lizard abundance. Tradeoffs related to agroforestry management included an inverse relationship between ground cover and hurricane resistance and more dominance of an invasive ant species in farms with higher shade canopies. We discuss the implications of practicing agroforestry principles in this smallholder coffee system and highlight opportunities to contribute to more diversified food production systems that support biodiversity and ecosystem services.

AbstractTo achieve commercial application of organic solar cells (OSCs), it is necessary to reduce material costs and improve device efficiency. This paper reports on the utilization of a multifunctional building block, namely 3‐cyanoesterthiophene, which exhibits simple structure and accessibility of synthetic for cost‐effective and high‐performance polymer donors (PDs). Meanwhile, ternary and terpolymerization strategies have been studied. Two similar PDs, PBTCl0‐TCA and PBTCl100‐TCA, are synthesized, and the devices exhibit less‐than‐satisfactory efficiency of 13.21% and 11.53% due to mismatching energy level and imperfect morphology. The two PDs with comparable structures and commendable compatibility easily form alloy‐like phase in active layer, which can effectively boost the efficiency of ternary devices to 14.17% with retained high JSC and significant improved open‐circuit voltage (VOC) and fill factor (FF). Encouraged by the ternary blending phenomenon, a polymer donor (PBTCl50‐TCA) with same ratio by random terpolymerization is designed. And over 17% efficiency binary OSCs using terpolymerization donor are demonstrated. The synergies of incorporation of the cyanoester‐group and terpolymer endow the developed PDs with deep‐lying energy levels, face‐on orientation, thermodynamic miscibility with the prevailing nonfullerene acceptor and appropriate polymer crystallinity. The findings study provide valuable insights and support for the advancement of cost‐effective and high‐performance PDs.

Dynamic compartmentalization is a prevailing principle regulating the spatiotemporal organization of the living cell membrane from the nano- up to the mesoscale. This non-arbitrary organization is intricately linked to cell function. On living cell membranes, dynamic domains or ‘membrane rafts' enriched with cholesterol, sphingolipids and other certain proteins exist at the nanoscale serving as signaling and sorting platforms. Moreover, it has been postulated that other local organizers of the cell membrane such as intrinsic protein interactions, the extracellular matrix and/or the actin cytoskeleton synergize with rafts to provide spatiotemporal hierarchy to the membrane. Elucidating the intricate coupling of multiple spatial and temporal scales requires the application of correlative techniques, with a particular need for simultaneous nanometer spatial precision and microsecond temporal resolution. Here, we review novel fluorescence-based techniques that readily allow to decode nanoscale membrane dynamics with unprecedented spatiotemporal resolution and single-molecule sensitivity. We particularly focus on correlative approaches from the field of nanophotonics. Notably, we introduce a versatile planar nanoantenna platform combined with fluorescence correlation spectroscopy to study spatiotemporal heterogeneities on living cell membranes at the nano- up to the mesoscale. Finally, we outline remaining future technological challenges and comment on potential directions to advance our understanding of cell membrane dynamics under the influence of the actin cytoskeleton and extracellular matrix in uttermost detail.

Introduction: Lung cancer is a progressive disease with the highest incidence and mortality rate of other cancer types. Besides, the low efficacy of current treatments used against lung cancer urges the need for novel alternative treatments. Method: Accordingly, quercetin (a flavonoid) has shown a mechanistic-based potential in preventing the progression of lung cancer. So, this study was designed to systematically review quercetin's therapeutic effects on the improvement of lung cancer. For this purpose, PubMed, Scopus and Cochrane library databases were searched based on the keywords lung cancer, lung carcinoma, lung adenocarcinoma and quercetin from 1997 to November 2021. We removed Non-English, repetitive, review and irrelevant articles according to title and abstract in the first step. After that, full-text screening was used to include the final studies. Results: From a total of 4341 results, finally 36 articles were included in the study, which the whole confirmed the therapeutic effects of quercetin on the improvement of lung malignancy. They also proved that quercetin has a synergic effect with chemical drugs used for lung cancer treatment. From the mechanical point of view, quercetin has employed several signaling mediators for lung therapeutic applications. This systematic review summarizes the modulatory effects of quercetin on several dysregulated pathways, including growth/proliferation, viability, migration/invasion, oxidative stress, inflammation and apoptosis. Conclusion: Prevailing studies show that quercetin interferes with molecular targets and mechanisms underlying lung cancer to prevent the development of such diseases in clinical applications.

AbstractThe concept of a ‘nexus’ across issues regarding the management of natural resources has gained increasing academic attention in recent years, but there is still relatively limited research on the application of the nexus approach for evaluating policies. This study analyses coherence among the main goals of five policy areas (water, energy, food, land, and climate) in Sweden, drawing upon a desk review, expert assessment, and interaction with stakeholders. The main objective is to enhance understanding of opportunities and challenges posed by such a nexus, understand policy interactions in Sweden, and provide insights into the use of policy coherence analysis as an integral part of resource nexus assessments. The analysis reveals synergies and conflicts between policy goals. For example, Sweden's environmental quality objectives (EQOs) regarding land and all the goals regarding water are either synergistic or neutral. Likewise, climate policy goals are well aligned with the goals regarding energy and ground water quality. On the other hand, the key goal for agriculture, which is food production, is the least coherent with those of the other policy areas. There are conflicts between the EQOs and goals regarding agricultural and forestry production. Stakeholders also indicate that climate goals are treated with higher priority than the goals of other policy areas. Notably, some interactions between policy goals are synergistic or conflicting depending on the context or their interpretation. Implementation of existing goals depends on relevant stakeholders' interests, priorities and interpretations, and on existing prevailing discourses in society, often supported by higher level policies.

Anthropogenic carbondioxide (CO2) emissions are a major factor in global warming, requiring significant cuts to combat climate change. A crucial technology to reduce global CO2 concentration is direct air capture (DAC) of CO2. However, existing DAC techniques are expensive because of low CO2 concentrations, and they frequently rely on fossil fuel-based energy. In this article, we investigate how wind turbines can influence local CO2 levels and potentially collaborate with DAC and other technologies. To explore this idea, we performed large-eddy simulations using two 5 MW commercial-scale wind turbines. We incorporated realistic CO2 profiles collected from 13 different global locations across different seasons. The simulations were performed under neutral atmospheric boundary layer conditions. The results demonstrate that the wake recovery mechanism of a wind turbine promotes rapid mixing of CO2 both above and below the turbine blade tips in the wind turbine wake. In cases where the initial concentrations of CO2 were elevated above the turbine, downward entrainment of CO2 occurred. Conversely, when high concentrations of CO2 were present in the lower atmosphere, wind turbines facilitated a decrease in concentration at that layer by up to 138 kg/m within the intermediate wake (within 7 diameters) of the second turbine, T2. These discoveries inspire further investigation into the potential synergies between wind turbines and DAC devices or local CO2 pollutant diverters, depending on the prevailing CO2 profile. Consequently, this article marks the initial showcase of wind turbines' capability to influence CO2 levels by creating an entrainment and removal effect.

PurposeThe purpose of the paper is to present a study which exploited synergies between the fields of Heritage BIM, conservation and building translocation to develop a new approach to support a digitally enabled translocation process. The translocation (or relocation) of buildings or structures is a niche area of the construction sector and much of the significant work in this field has focused on the relocation of heritage buildings. However, hitherto there was a paucity of work between translocation and the process and technology of BIM.Design/methodology/approachThe study employed a constructive research approach to analyse the phenomenon of heritage translocation. As part of this approach, semi-structured interviews were undertaken with professionals engaged in heritage translocation projects within the UK, and this was supported by a multi-faceted review of literature within the cross cutting themes of translocation and HBIM. Building on the results, a BIM-enabled process was implemented to support the translocation of a 19th-century timber framed building in the UK.FindingsFollowing analysis of results of semi-structured interviews and supported by findings from prevailing literature in the field of translocation and HBIM, a HBIM for Translocation Conceptual Framework (TransHBIM) was developed. Building on the key constructs of the framework, a HBIM-based workflow was implemented to develop a digitally enabled translocation process, which provided a new approach to managing and documenting heritage translocation where disassembly and reconstruction are utilised. The workflow provided a more effective way of documenting individual elements of the building within a digital environment opening up potential for new simulation of the entire process.Originality/valueCurrent approaches to translocation involve traditional/manual methods of recording the building and cataloguing the key heritage elements for all aspects of the process. This new approach implements BIM technologies and processes along with the use of barcode or RFID tags to create a digital bridge between the physical elements of the building and the BIM database. This provides more accurate recording of the heritage and also opens up opportunities to support the process with additional digital simulation techniques enhancing the efficiency of the entire process.

Global environmental change is a defining issue of our time. The ocean is a key component of the Earth system, and yet, in-depth understanding of its roles in sustaining life has not received the attention which it deserves. Humanity must develop a new relationship with the ocean characterized by protection, sustainable production, and prosperity. Society has too much to gain by implementing sustainability solutions and too much to lose by ignoring them. Our actions or inaction now will have far-reaching implications for future of all life on Earth. Ocean blueprint that calls for enforcing 30% Marine Protected Areas by 2030 requires real transformative action. This paper contains new ideas for combining the efforts of natural and social scientists, and traditional users of sea, and explores the potential of modern technologies to assist in this campaign. ‘Smart Sea’ concept introduced in this paper envisages synergies among the problem-solving approaches including digital tools, and eco-engineering and eco-mimicry solution options. Knowledge gaps have been highlighted and relevance of new knowledge systems emphasized together with enabling conditions to address the uncertainties associated with the ocean ecosystem. The ocean has a central position in actions towards preventing global warming of 1.5oC but measures to achieve it should consider that the ocean carbon sink is dynamic and is adversely affected when excessive carbon dioxide produces acidification. The selected measures are likely to have trade-offs, requiring analysis of multiple dimensions, for ensuring sustainable outcomes. The prevailing ocean health and urgency to mitigate it calls for combining global and local solutions, technologies and actions driven by safe and innovative solutions, and wherever possible, based on proof-of-concept. Deviating from the on-going incremental data collection systems to new forms of data-sharing using modern technological tools will contribute to addressing the glaring vacuum in knowledge of the ocean and facilitating a concerted global action for maintaining its ecosystem services. An attempt has been made in this paper to consolidate different opinions and experiences in moving from generalities to specifics for sustainable solutions that support economies, food security and the society.

As European governments adopt new circular built environment policies to cope with the socio-ecological crisis, the need for evaluating such policies gains in urgency. Ex post evaluation is, however, difficult as these policies have not been in place long enough to have had significant effects. Nonetheless, ex ante policy evaluation may be possible by assessing policy coherence or the alignment and synergies of policy goals, instruments and implementation practices. This paper proposes a framework to analyse circular built environment policies. This framework is based on a combination of two existing analytical frameworks: circular city development and policy coherence analysis. The framework is tested for the case of a circular built environment in campus development at Delft University of Technology in the Netherlands, which is regarded as an urban development proxy. Policy documents and semi-structured interviews were analysed and coded. Results confirm previous findings about a prevailing focus on looping actions and indicates limited policy instrumentalisation across governance levels. Identified multilevel (in)coherence in circular city policy is pointed out as consequence of siloed-led and supply chain-based thinking and underdeveloped circular policy frameworks. Finally, the analytical benefits of circular city development and policy coherence frameworks are discussed. Policy relevance Circular economy policies are conceptually limited in delivering a more circular city and built environment. By proposing and testing a circular city policy coherence framework, this article reveals the limited effect of circular economy policies in coping with unsustainable urbanisation. Policymaking and implementation for circularity in the built environment require frameworks that embrace urban complexities instead of reductionist approaches seeing the built environment as a mere agglomeration of supply-chains. Policymakers may use the proposed circular city policy coherence framework as a tool for ex ante policy evaluation in diverse areas of urban development, and specifically for built environment interventions. The combination of both content- and process-based frameworks enables the identification of possible (in)coherence in current and future policy goals, instruments and implementation practices. This can improve policy in early stages of implementation and create more effective policy outputs and outcomes in the long term.

“What if we were to go into culture tongue-first to see how things taste?” (Jenkins 5) Released in June of 2005, Tim Burton’s Charlie and the Chocolate Factory has all the ingredients of a blockbuster success; a well known story-line, a target youth demographic, a nostalgic adult audience and a multi-million dollar synergy between media giants AOL Time Warner and transnational food corporation Nestlé. Yet, when it comes to discussing the affect-oriented components of the marketing campaign behind this film, much contemporary academic scholarship falls short of offering a substantial framework for theoretical analysis. Defined broadly as a subjective, felt experience, the notion of affect has traditionally fought an uphill battle for scholarly recognition within media studies. Against a backdrop of objective rationality and quantitative analysis, the touching, smelling and tasting components of media consumption have been systematically disregarded in favour of the audio-visual pleasures of the filmic medium. However, as the recent cross-promotional strategies underpinning Charlie and the Chocolate Factory reveal, the tactile, olfactory and gustatory components of moviegoing are often central to global media consumption practices. The synergised marketing initiatives between AOL/Time-Warner and Nestlé confectionary exemplify the significance of affect within globalised media consumption. Drawing on Roald Dahl’s 1964 children’s classic of the same name, the recent revamping of Charlie and the Chocolate Factory explicitly utilises Nestlé confectionary as a nexus between the seemingly incommensurate realms of transnational media distribution/commerce and the consuming, sentient bodies of actual movie-goers. In direct contrast to Stuart’s 1971 film Willy Wonka and the Chocolate Factory, which offered audiences an audio-visual representation of hedonistic indulgence, the Warner/Nestlé agreement effectively ensures an edible cinematic adventure, in which audiences are enticed to consume “actual” (Nestlé) Wonka bars as part of the movie experience. The following enticement from a recent Nestlé press release is explicit in this regard: “You dreamt of them in the book, you will yearn for them in the film and now you can finally taste scrumptiously sumptuous Wonka Bars” (Drew 1). In keeping with this cross-promotion, the majority of Wonka products seen in Burton’s Charlie and the Chocolate Factory have identical wrappings to the merchandise currently being promoted in retail outlets across the United States, Canada, Europe and Australasia. In thus establishing distinct syntagmatic relationships between the film’s diegisis and its “real world” marketing campaign Warner and Nestlé have ensured a form of media consumption that moves beyond ocularcentric understandings of “spectatorship” and into the uncharted realms of the emotional and the visceral. Nestlé’s use of the enigmatic character Wonka and his extraordinary confectionary provides another palpable demonstration of this politics of affect: Willy Wonka, the world’s most eminent chocolatier, has created a scrumdiddlyumptious selection of delectable treats to choose from. The enticing Wonka Bars tempt you in three tantalisingly tasty flavours: Whipple-Scrumptious Fudgemallow Delight, Nutty Crunch Surprise (the surprise is that it contains no nuts!) and Triple Dazzle Caramel (Drew 1). In terms of media affect, the implications of this phenomenon are significant. Far from being confined to the audio-visual specificities of the filmic medium, contemporary audiences are being lured into an entertainment experience that can not only be seen and heard, but also smelled, touched and tasted. These sense-oriented marketing strategies are indicative of what John Hannigan has identified as “eatertainment”, an affective synapse of consumer activity “in which the former boundaries between eating and play are collapsed and recast into something new” (93). In offering audiences an edible cinematic experience, the Nestlé -Warner cross-promotion not only ensures a potentially novel trip to the cinemas, but also a repeat purchase scenario, whereby Wonka-themed confectionary is able to be purchased several times after just one viewing of Burton’s film. The notion of eatertainment is certainly paying off for Nestlé. With a product placement deal in excess of nine million U.S. dollars, Nestlé’s Wonka confectionery range is given optimum exposure throughout the film. According to The Atlanta Journal, the preparation for this placement required Nestlé to produce and wrap over 110,000 fake chocolate bars; most of which were used in the scene in Mr Salt’s factory where hundreds of his employees are seen ripping open Wonka bars in the hope of finding a golden ticket for Mr. Salt’s infamous daughter Veruca (Bookman 8). In tandem with this placement, Nestlé UK also launched a £1.5m television advertising campaign replete with a “golden ticket” promotion, which promised several ‘lucky consumers’ the chance to win a golden ticket: Everybody has a chance of finding one of the most sought after tickets underneath their Wonka Bar wrapper, as featured in the film. The lucky golden ticket winners will be treated to a trip of a lifetime to visit a chocolate factory and Warner Bros Studios in America (Drew 1). The Nestlé/Wonka connection was forged in 1999 after Nestlé purchased Rowntree confectionary. Taking its incentive from both the novel and the subsequent 1971 film, Nestlé re-launched Rowntree’s relatively underdeveloped Wonka range and transformed it into a major brand which now has an annual income of over $121 million U.S (Jardine 8). To date, there are over two dozen products in the Wonka range and all of them manage to tie in with Roald Dahl’s earlier discourses of mischief, eccentricity and gustatory bliss. Included amongst the Wonka range are products such as Laffy Taffy, Nerds, Oompahs, and Wonka Bars, with nearly all of the existing products carrying the tag-line; “Wonka, what will he think of next?”. Discussing the evolution of the Wonka brand, Frank Arthofer, CEO of Nestlé chocolate and confections, noted that “the tag-line is intended to capture the innovation and unpredictability of the brand and further the image of Willy Wonka as an inventor” (Thompson 14). In fortifying this agenda, Nestlé also hosts a Wonka Website in which children are encouraged to play interactive Wonka games such as ‘Oompahs Outrageous Rush’ and ‘Gobstopper Gobbler”. Of course, this is not the first time that media giants have aggressively marketed food as an integral component to the cinematic experience. In 1996, Disney and McDonalds collaborated on a $US four billion cross-promotional exercise (Howard 2). Since then, McDonalds and Disney have launched numerous “McDisney” packages, many of which have included film-specific foods such as banana-flavoured sundaes and “jungle burgers” to tie in with Disney’s 1999 animated film Tarzan. However, unlike the McDonalds/Disney agreement, in which the food operates as an indexical signifier of the film (and not vice-versa), the Nestlé /Warner promotion takes the politics of affect one step further and encourages a mutually beneficial process of signification whereby the food signifies the film and the film signifies the food. It’s a scenario that blatantly ensures a form of visceral connectivity between the audience, the film and the tangible product. To this end, an analysis of the synergised marketing campaign behind Charlie and the Chocolate Factory reveals a persistent and efficient politics of affect in which the neo-liberal agendas of both Nestlé and Time-Warner are affectively absorbed into the sensual and desiring bodies of media audiences. Such initiatives signal a significant departure from traditional audio-visual marketing campaigns in as much as audiences are now being expected to literally swallow the saccharine-tinged marketing agendas of not one, but two, multinational corporations. While prevailing theoretical analysis of media consumption struggles against the traditional confines of rational objectivity, transnational media networks are productively utilising the audiences’ desire to be affectively engaged in the cinematic experience. As the cross-promotional tie-in deals behind Burton’s Charlie and the Chocolate Factory clearly reveal, the contemporary media-scape is one which deliberately lures audiences on the basis of their sensuous, emotional and subjective capacities. References Bookman, Julie. “News for Kids.” The Atlanta Journal 18 July 2005: B8. Charlie and the Chocolate Factory. Directed by Tim Burton. 2005. Dahl, Roald. Charlie and the Chocolate Factory. London: Penguin, 1964. Drew, Cathy. “The Marvellously Mouth-Watering Wonka Bars.” Nestlé UK Wonka Press Release 26 July 2005. 24 Aug. 2005 http://www.nestle.co.uk/PressOffice/MediaKit/PressReleases/ ConfectioneryNews/Mouth-wateringWonkaBars.htm>. Howard, Thomas. “Disney Alliance Shows Brute Force.” Nations Restaurant News: The Weekly Newspaper of the Food Industry 2 Dec. 1996. Jardine, Alice. “Nestlé Plans Wonka Push in the UK.” Marketing 29 Apr. 1999: 8. Jenkins, Emily. Tongue First: Adventures in Physical Culture. New York: Virago Press, 1998. Tarzan. Directed by C. Buck. 1999. Thompson, Stephanie. “Nestlé Works to Build Wonka Brand.” Advertising Age 15 Nov. 1999: 14. Willy Wonka and the Chocolate Factory. Directed by M. Stuart. 1971. Wonka Website. http://www.wonka.com>. Citation reference for this article MLA Style Downing, Leanne. "Media Synergies and the Politics of Affect in Tim Burton’s Charlie and the Chocolate Factory (2005)." M/C Journal 8.6 (2005). echo date('d M. Y'); ?> <http://journal.media-culture.org.au/0512/11-downing.php>. APA Style Downing, L. (Dec. 2005) "Media Synergies and the Politics of Affect in Tim Burton’s Charlie and the Chocolate Factory (2005)," M/C Journal, 8(6). Retrieved echo date('d M. Y'); ?> from <http://journal.media-culture.org.au/0512/11-downing.php>.

The creation of entities to pursue scholarship that bridge disciplines is a common occurrence in a modern university. This trend has been particularly acute with respect to the field of global health, given its development, over the last 20 years, as a major field of research and training, the availability of large associated sources of funding, and the emergence of major worldwide partnerships for global health. What is the unique mission of a university-wide entity dedicated to global health in a large university that already has a diverse set of faculty working on global health dispersed in many of its academic units? This is a situation facing many universities today. Some argue that the obvious “added value” of such an entity, whether a Center, Institute, Program, or other construct, is to function as a hub for information and sponsor of global health seminars, workshops, and courses; a cross-campus synthesizer of research and training initiatives in global health; a source of pilot funding for new initiatives; and as a service center, i.e., providing the legal, financial, operational, technological, ethical, and compliance issues inherent in working internationally. Another potential “added value” of such a hub is the identification and pursuit of new major research and knowledge translation initiatives that capitalize on the synergies potentially offered by an entity that connects scholars across many disciplines and that do not merely “cannibalize” existing efforts. In this paper, we summarize the perspective, process, and outcomes associated with creating an “added value” institute of global health at the University of Toronto. We proposed from the outset that the most impactful “added value” of such an entity would be the creation of a new category, one guided by a fresh pedagogy that allows all of its stakeholders – students, faculty, staff and partners, particularly from the corporate, non-profit, public and community sectors – to look critically at how health equity is impacted by current institutional arrangements and prevailing power dynamics between the “haves” and the “have nots”, and across multiple levels of privilege. With this foundational understanding, this hub can enable its stakeholders (with students and communities as its top priorities) to work in multi-disciplinary, multi-sectoral social innovation teams towards social and economic convergence to improve health equity locally and globally.

Photo by Sean Pollock on Unsplash ABSTRACT Bioethics and Corporate Social Responsibility (CSR) were born out of similar concerns, such as the reaction to scandal and the restraint of irresponsible actions by individuals and organizations. However, these fields of knowledge are seldom explored together. This article attempts to explain the motives behind the gap between bioethics and CSR, while arguing that their shared agenda – combined with their contrasting principles and goals – suggests there is potential for fruitful dialogue that enables the actualization of bioethical agendas and provides a direction for CSR in health-related organizations. INTRODUCTION Bioethics and Corporate Social Responsibility (CSR) seem to be cut from the same cloth: the concern for human rights and the response to scandal. Both are tools for the governance of organizations, shaping how power flows and decisions are made. They have taken the shape of specialized committees, means of stakeholder inclusion at deliberative forums, compliance programs, and internal processes. It should be surprising, then, that these two fields of study and practice have developed separately, only recently re-approaching one another. There have been displays of this reconnection both in academic and corporate spaces, with bioethics surfacing as part of the discourse of CSR and compliance initiatives. However, this is still a relatively timid effort. Even though the bioethics-CSR divide presents mostly reasonable explanations for this difficult relationship between the disciplines, current proposals suggest there is much to be gained from a stronger relationship between them. This article explores the common history of bioethics and corporate social responsibility and identifies their common features and differences. It then explores the dispute of jurisdictions due to professional and academic “pedigree” and incompatibilities in the ideological and teleological spheres as possible causes for the divide. The discussion turns to paths for improving the reflexivity of both disciplines and, therefore, their openness to mutual contributions. I. Cut Out of the Same Cloth The earliest record of the word “bioethics” dates back to 1927 as a term that designates one’s ethical responsibility toward not only human beings but other lifeforms as well, such as animals and plants.[1] Based on Kantian ethics, the term was coined as a response to the great prestige science held at its time. It remained largely forgotten until the 1970s, when it resurfaced in the United States[2] as the body of knowledge that can be employed to ensure the responsible pursuit and application of science. The resurgence was prompted by a response to widespread irresponsible attitudes toward science and grounded in a pluralistic perspective of morality.[3] In the second half of the twentieth century, states and the international community assumed the duty to protect human rights, and bioethics became a venue for discussing rights.[4] There is both a semantic gap and a contextual gap between these two iterations, with some of them already being established. Corporate social responsibility is often attributed to the Berle-Dodd debate. The discussion was characterized by diverging views on the extent of the responsibility of managers.[5] It was later settled as positioning the company, especially the large firm, as an entity whose existence is fomented by the law due to its service to the community. The concept has evolved with time, departing from a largely philanthropic meaning to being ingrained in nearly every aspect of a company’s operations. This includes investments, entrepreneurship models, and its relationship to stakeholders, leading to an increasing operationalization and globalization of the concept.[6] At first sight, these two movements seem to stem from different contexts. Despite the difference, it is also possible to tell a joint history of bioethics and CSR, with their point of contact being a generalized concern with technological and social changes that surfaced in the sixties. The publishing of Silent Spring in 1962 by Rachel Carson exemplifies this growing concern over the sustainability of the ruling economic growth model of its time by commenting on the effects of large-scale agriculture and the use of pesticides in the population of bees, one of the most relevant pollinators of crops consumed by humans. The book influenced both the author responsible for the coining bioethics in the 1971[7] and early CSR literature.[8] By initiating a debate over the sustainability of economic models, the environmentalist discourse became a precursor to vigorous social movements for civil rights. Bioethics was part of the trend as it would be carried forward by movements such as feminism and the patients’ rights movement.[9] Bioethics would gradually move from a public discourse centered around the responsible use of science and technology to academic and government spaces.[10] This evolution led to an increasing emphasis on intellectual rigor and governance. The transformation would unravel the effort to take effective action against scandal and turn bioethical discourse into governance practices,[11] such as bioethics and research ethics committees. The publication of the Belmont Report[12] in the aftermath of the Tuskegee Syphilis Experiment, as well as the creation of committees such as the “God Committee,”[13] which aimed to develop and enforce criteria for allocating scarce dialysis machines, exemplify this shift. On the side of CSR, this period represents, at first, a stronger pact between businesses and society due to more stringent environmental and consumer regulations. But afterward, a joint trend emerged: on one side, the deregulation within the context of neoliberalism, and on the other, the operationalization of corporate social responsibility as a response to societal concerns.[14] The 1990s saw both opportunities and crises that derived from globalization. In the political arena, the end of the Cold War led to an impasse in the discourse concerning human rights,[15] which previously had been split between the defense of civil and political rights on one side and social rights on the other. But at the same time, agendas that were previously restricted territorially became institutionalized on a global scale.[16] Events such as the European Environment Agency (1990), ECO92 in Rio de Janeiro (1992), and the UN Global Compact (2000) are some examples of the globalization of CSR. This process of institutionalization would also mirror a crisis in CSR, given that its voluntarist core would be deemed lackluster due to the lack of corporate accountability. The business and human rights movement sought to produce new binding instruments – usually state-based – that could ensure that businesses would comply with their duties to respect human rights.[17] This rule-creation process has been called legalization: a shift from business standards to norms of varying degrees of obligation, precision, and delegation.[18] Bioethics has also experienced its own renewed identity in the developed world, perhaps because of its reconnection to public and global health. Global health has been the object of study for centuries under other labels (e.g., the use of tropical medicine to assist colonial expeditions) but it resurfaced in the political agenda recently after the pandemics of AIDS and respiratory diseases.[19] Bioethics has been accused from the inside of ignoring matters beyond the patient-provider relationship,[20] including those related to public health and/or governance. Meanwhile, scholars claimed the need to expand the discourse to global health.[21] In some countries, bioethics developed a tight relationship with public health, such as Brazil,[22] due to its connections to the sanitary reform movement. The United Kingdom has also followed a different path, prioritizing governance practices and the use of pre-established institutions in a more community-oriented approach.[23] The Universal Declaration on Bioethics and Rights followed this shift toward a social dimension of bioethics despite being subject to criticism due to its human rights-based approach in a field characterized by ethical pluralism.[24] This scenario suggests bioethics and CSR have developed out of similar concerns: the protection of human rights and concerns over responsible development – be it economic, scientific, or technological. However, the interaction between these two fields (as well as business and human rights) is fairly recent both in academic and business settings. There might be a divide between these fields and their practitioners. II. A Tale of Jurisdictions It can be argued that CSR and business and human rights did not face jurisdictional disputes. These fields owe much of their longevity to their roots in institutional economics, whose debates, such as the Berle-Dodd debate, were based on interdisciplinary dialogue and the abandonment of sectorial divisions and public-private dichotomies.[25] There was opposition to this approach to the role of companies in society that could have implications for CSR’s interdisciplinarity, such as the understanding that corporate activities should be restricted to profit maximization.[26] Yet, those were often oppositions to CSR or business and human rights themselves. The birth of bioethics in the USA can be traced back to jurisdictional disputes over the realm of medicine and life sciences.[27] The dispute unfolded between representatives of science and those of “society’s conscience,” whether through bioethics as a form of applied ethics or other areas of knowledge such as theology.[28] Amid the civil rights movements, outsiders would gain access to the social sphere of medicine, simultaneously bringing it to the public debate and emphasizing the decision-making process as the center of the medical practice.[29] This led to the emergence of the bioethicist as a professional whose background in philosophy, theology, or social sciences deemed the bioethicist qualified to speak on behalf of the social consciousness. In other locations this interaction would play out differently: whether as an investigation of philosophically implied issues, a communal effort with professional institutions to enhance decision-making capability, or a concern with access to healthcare.[30] In these situations, the emergence and regulation of bioethics would be way less rooted in disputes over jurisdictions. This contentious birth of bioethics would have several implications, most related to where the bioethicist belongs. After the civil rights movements subsided, bioethics moved from the public sphere into an ivory tower: intellectual, secular, and isolated. The scope of the bioethicist would be increasingly limited to the spaces of academia and hospitals, where it would be narrowed to the clinical environment.[31] This would become the comfort zone of professionals, much to the detriment of social concerns. This scenario was convenient to social groups that sought to affirm their protagonism in the public arena, with conservative and progressive movements alike questioning the legitimacy of bioethics in the political discourse.[32] Even within the walls of hospitals and clinics, bioethics would not be excused from criticism. Afterall, the work of bioethicists is often unregulated and lacks the same kind of accountability that doctors and lawyers have. Then, is there a role to be played by the bioethicist? This trend of isolation leads to a plausible explanation for why bioethics did not develop an extensive collaboration with corporate social responsibility nor with business and human rights. Despite stemming from similar agendas, bioethics’ orientation towards the private sphere resulted in a limited perspective on the broader implications of its decisions. This existential crisis of the discipline led to a re-evaluation of its nature and purpose. Its relevance has been reaffirmed due to the epistemic advantage of philosophy when engaging normative issues. Proper training enables the bioethicist to avoid falling into traps of subjectivism or moralism, which are unable to address the complexity of decision-making. It also prevents the naïve seduction of “scientifying” ethics.[33] This is the starting point of a multitude of roles that can be attributed to the bioethicists. There are three main responsibilities that fall under bioethics: (i) activism in biopolicy, through the engagement in the creation of laws, jurisprudence, and public policies; (ii) the exercise of bioethics expertise, be it through the specialized knowledge in philosophical thought, its ability to juggle multiple languages related to various disciplines related to bioethics, or its capacity to combat and avoid misinformation and epistemic distortion; (iii) and, intellectual exchange, by exercising awareness that it is necessary to work with specialists from different backgrounds to achieve its goals.[34] All of those suggest the need for bioethics to improve its dialogue with CSR and business and human rights. Both CSR and business and human rights have been the arena of political disputes over the role of regulations and corporations themselves, and the absence of strong stances by bioethicists risks deepening their exclusion from the public arena. Furthermore, CSR and business and human rights are at the forefront of contemporary issues, such as the limits to sustainable development and appropriate governance structures, which may lead to the acceptance of values and accomplishment of goals cherished by bioethics. However, a gap in identifying the role and nature of bioethics and CSR may also be an obstacle for bridging the chasm between bioethics and CSR. III. From Substance to Form: Philosophical Groundings of CSR and Bioethics As mentioned earlier, CSR is, to some extent, a byproduct of institutionalism. Institutional economics has a philosophical footprint in the pragmatic tradition[35], which has implications for the purpose of the movement and the typical course of the debate. The effectiveness of regulatory measures is often at the center of CSR and business and human rights debates: whatever the regulatory proposal may be, compliance, feasibility, and effectiveness are the kernel of the discussion. The axiological foundation is often the protection of human rights. But discussions over the prioritization of some human rights over others or the specific characteristics of the community to be protected are often neglected.[36] It is worth reinforcing that adopting human rights as an ethical standard presents problems to bioethics, given its grounding in the recognition of ethical pluralism. Pragmatism adopts an anti-essentialist view, arguing that concepts derive from their practical consequences instead of aprioristic elements.[37] Therefore, truth is transitory and context dependent. Pragmatism embraces a form of moral relativism and may find itself in an impasse in the context of political economy and policymaking due to its tendency to be stuck between the preservation of the status quo and the defense of a technocratic perspective, which sees technical and scientific progress as the solution to many of society’s issues.[38] These characteristics mean that bioethics has a complicated relationship with pragmatism. Indeed, there are connections between pragmatism and the bioethics discourse. Both can be traced back to American naturalism.[39] The early effort in bioethics to make it ecumenical, thus building on a common but transitory morality,[40] sounds pragmatic. Therefore, scholars suggest that bioethics should rely on pragmatism's perks and characteristics to develop solutions to new ethical challenges that emerge from scientific and technological progress. Nonetheless, ethical relativism is a problem for bioethics when it bleeds from a metaethical level into the subject matters themselves. After all, the whole point of bioethics is either descriptive, where it seeks to understand social values and conditions that pertain to its scope, or normative, where it investigates what should be done in matters related to medicine, life sciences, and social and technological change. It is a “knowledge of how to use knowledge.” Therefore, bioethics is a product of disillusionment regarding science and technology's capacity to produce exclusively good consequences. It was built around an opposition to ethical relativism—even though the field is aware of the particularity of its answers. This is true not only for the scholarly arena, where the objective is to produce ethically sound answers but also for bioethics governance, where relativism may induce decision paralysis or open the way to points of view disconnected from facts.[41] But there might be a point for more pragmatic bioethics. Bioethics has become an increasingly public enterprise which seeks political persuasion and impact in the regulatory sphere. When bioethics is seen as an enterprise, achieving social transformation is its main goal. In this sense, pragmatism can provide critical tools to identify idiosyncrasies in regulation that prove change is needed. An example of how this may play out is the abortion rights movement in the global south.[42] Despite barriers to accessing safe abortion, this movement came up with creative solutions and a public discourse focused on the consequences of its criminalization rather than its moral aspects. IV. Bridging the Divide: Connections Between Bioethics and CSR There have been attempts to bring bioethics and CSR closer to each other. Corporate responsibility can be a supplementary strategy for achieving the goals of bioethics. The International Bioethics Committee (IBC), an institution of the United Nations Educational, Scientific and Cultural Organization (UNESCO), highlights the concept that social responsibility regarding health falls under the provisions of the Universal Declaration on Bioethics and Human Rights (UDBHR). It is a means of achieving good health (complete physical, mental, and social well-being) through social development.[43] Thus, it plays out as a condition for actualizing the goals dear to bioethics and general ethical standards,[44] such as autonomy and awareness of the social consequences of an organization’s governance. On this same note, CSR is a complementary resource for healthcare organizations that already have embedded bioethics into their operations[45] as a way of looking at the social impact of their practices. And bioethics is also an asset of CSR. Bioethics can inform the necessary conditions for healthcare institutions achieving a positive social impact. When taken at face value, bioethics may offer guidelines for ethical and socially responsible behavior in the industry, instructing how these should play out in a particular context such as in research, and access to health.[46] When considering the relevance of rewarding mechanisms,[47] bioethics can guide the establishment of certification measures to restore lost trust in the pharmaceutical sector.[48] Furthermore, recognizing that the choice is a more complex matter than the maximization of utility can offer a nuanced perspective on how organizations dealing with existentially relevant choices understand their stakeholders.[49] However, all of those proposals might come with the challenge of proving that something can be gained from its addition to self-regulatory practices[50] within the scope of a dominant rights-based approach to CSR and global and corporate law. It is evident that there is room for further collaboration between bioethics and CSR. Embedding either into the corporate governance practices of an organization tends to be connected to promoting the other.[51] While there are some incompatibilities, organizations should try to overcome them and take advantage of the synergies and similarities. CONCLUSION Despite their common interests and shared history, bioethics and corporate social responsibility have not produced a mature exchange. Jurisdictional issues and foundational incompatibilities have prevented a joint effort to establish a model of social responsibility that addresses issues particular to the healthcare sector. Both bioethics and CSR should acknowledge that they hold two different pieces of a cognitive competence necessary for that task: CSR offers experience on how to turn corporate ethical obligations operational, while bioethics provides access to the prevailing practical and philosophical problem-solving tools in healthcare that were born out of social movements. Reconciling bioethics and CSR calls for greater efforts to comprehend and incorporate the social knowledge developed by each field reflexively[52] while understanding their insights are relevant to achieving some common goals. - [1]. Fritz Jahr, “Bio-Ethik: Eine Umschau Über Die Ethischen Beziehungen Des Menschen Zu Tier Und Pflanze,” Kosmos - Handweiser Für Naturfreunde 24 (1927): 2–4. [2]. Van Rensselaer Potter, “Bioethics, the Science of Survival,” Perspectives in Biology and Medicine 14, no. 1 (1970): 127–53, https://doi.org/10.1353/pbm.1970.0015. [3]. Maximilian Schochow and Jonas Grygier, eds., “Tagungsbericht: 1927 – Die Geburt der Bioethik in Halle (Saale) durch den protestantischen Theologen Fritz Jahr (1895-1953),” Jahrbuch für Recht und Ethik / Annual Review of Law and Ethics 21 (June 11, 2014): 325–29, https://doi.org/10.3726/978-3-653-02807-2. [4] George J. Annas, American Bioethics: Crossing Human Rights and Health Law Boundaries (Oxford ; New York: Oxford University Press, 2005). [5] Philip L. Cochran, “The Evolution of Corporate Social Responsibility,” Business Horizons 50, no. 6 (November 2007): 449–54, https://doi.org/10.1016/j.bushor.2007.06.004. p. 449. [6] Mauricio Andrés Latapí Agudelo, Lára Jóhannsdóttir, and Brynhildur Davídsdóttir, “A Literature Review of the History and Evolution of Corporate Social Responsibility,” International Journal of Corporate Social Responsibility 4, no. 1 (December 2019): 23, https://doi.org/10.1186/s40991-018-0039-y. [7] Potter, “Bioethics, the Science of Survival.” p. 129. [8] Latapí Agudelo, Jóhannsdóttir, and Davídsdóttir, “A Literature Review of the History and Evolution of Corporate Social Responsibility.” p. 4. [9] Albert R. Jonsen, The Birth of Bioethics (New York: Oxford University Press, 2003). p. 368-371. [10] Jonsen. p. 372. 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