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Dissertations / Theses on the topic 'Syncytiotrophoblasts'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Reid, Neil A. "Molecular and cellular studies on placental glucose transport." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318590.

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2

Rao, M. Rekha. "Functional Differentiation Of The Human Placenta : Insights From The Expression Of Two Developmentally - Regulated Genes." Thesis, Indian Institute of Science, 2000. http://hdl.handle.net/2005/177.

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Placenta is a transient association of the fetal and maternal tissues, that develops during pregnancy, in most viviparous animals. The evolution of placenta ensured the development of the fetus inside the womb of the mother, providing a protected environment for the development of the fetus, and preventing the loss of progeny due to unfavorable environmental conditions. Because it is strategically poised at the maternal and fetal interface, the placenta is ideally suited to carry out alimentary, respiratory and excretory functions for the developing fetus. In addition, it serves as an immunolo

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3

Kenton, Paul. "Studies of signalling pathways in human syncytiotrophoblast." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358992.

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4

Kumar, Surendran Sailesh. "Pre-eclampsia, shed membrane microparticles and syncytiotrophoblast apoptosis." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365865.

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5

Knight, Marian. "Syncytiotrophoblast microvillous membrane deportation in the pathogenesis of pre-eclampsia." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389045.

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6

Carey, Julie. "NUMB and Syncytiotrophoblast Development and Function: Investigation Using BeWo Choriocarcinoma Cells." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22846.

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The role of NUMB, a protein important for cellular differentiation and endocytosis in non-placental cells, was investigated in syncytiotrophoblast development and function in the human placenta. The BeWo choriocarcinoma cell line was used as a model for villous cytotrophoblast cells and syncytiotrophoblast to investigate NUMB’s involvement in differentiation and epidermal growth factor receptor (EGFR) endocytosis. NUMB isoforms 1 and 3 were found to be the predominant isoforms and were upregulated following forskolin-induced differentiation. Overexpression of NUMB isoforms 1 and 3 did not medi

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7

Germain, Sarah. "The maternal inflammatory response and circulating syncytiotrophoblast microparticles in normal pregnancy and pre-eclampsia." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413085.

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8

Lofthouse, E. M. "The accumulation of glutamate in the placental syncytiotrophoblast as a driver of membrane transport." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/374566/.

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9

Gupta, Anurag Kumar. "Immune-modulation by the placenta and its dysregulation in preeclampsia : role of syncytiotrophoblast microparticles and cytokines /." Basel : [s.n.], 2005. http://edoc.unibas.ch/diss/DissB_7215.

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10

Haghighi, Poodeh S. (Saeid). "Novel pathomechanisms of intrauterine growth restriction in fetal alcohol syndrome in a mouse model." Doctoral thesis, Oulun yliopisto, 2016. http://urn.fi/urn:isbn:9789526213163.

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Abstract Fetal alcohol syndrome (FAS) is a pattern of anomalies in affected children due to maternal alcohol administration at vulnerable stages of fetal development. Intrauterine growth restriction and facial malformation are the presenting phenotypes of FAS. In this investigation, novel pathomechanisms of intrauterine growth restriction and facial malformation were the primary aims. We found by a FAS mouse model that AceCS1 gene expression and polyamines are the immediate targets of fetal alcohol exposure. The AceCS1 product is a precursor for lipid synthesis and protein acetylation and poss

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11

Lecarpentier, Edouard. "Etude des flux sanguins dans le placenta humain et influence du shear stress sur la fonction biologique du syncytiotrophoblaste." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB052/document.

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La placentation humaine est de type hémomonochoriale, le sang maternel est directement en contact avec le syncytiotrophoblaste. Les flux sanguins maternels, dans la chambre intervilleuse, exercent des forces mécaniques de cisaillement (shear stress) sur la surface microvillositaire du syncytiotrophoblaste. Les effets physiologiques du shear stress exercé par les flux sanguins sur l’endothélium vasculaire artériel et veineux ont fait l’objet de nombreux travaux scientifiques. En revanche, les effets biologiques du shear stress sur le syncytiotrophoblaste humain n’ont jamais été explorés. L’obje

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12

Hurst, Georgina Jane. "The purification and characterisation of syncytiotrophoblast factors which disrupt endothelial cell function : their relevance to the maternal syndrome of pre-eclampsia." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301847.

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13

Bezerra, Ferdinando Vinícius Fernandes. "A subplacenta do preá Galea spixii Wagler, 1831." Universidade Federal Rural do Semi-Árido, 2014. http://bdtd.ufersa.edu.br:80/tede/handle/tede/361.

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Made available in DSpace on 2016-08-15T20:31:21Z (GMT). No. of bitstreams: 1 FerdinandoVFB_DISSERT.pdf: 10097957 bytes, checksum: aaf72cc9003c689e5792192fd220aef8 (MD5) Previous issue date: 2014-02-28<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The subplacenta is considered an ideal model for comparative studies of trophoblastic processes in humans. Thus, the aim of this study was made a morphological description of the development of the Spix s yellow-toothed cavy. To do this, 12 females were distributed in three groups in a proportion of 1 male to 4 females, kept in

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14

Hedlund, Malin. "Exosomes and the NKG2D receptor-ligand system in pregnancy and cancer : using stress for survival." Doctoral thesis, Umeå universitet, Klinisk immunologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-37122.

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Although not obvious at first sight, several parallels can be drawn between pregnancy andcancer. Many proliferative, invasive and immune tolerance mechanisms that supportnormal pregnancy are also exploited by malignancies to establish a nutrient supply andevade or edit the immune response of the host. The human placenta, of crucial importancefor pregnancy success, and its main cells, the trophoblast, share several features withmalignant cells such as high cell proliferation rate, lack of cell-contact inhibition andinvasiveness. Both in cancer and in pregnancy, the immune defense mechanisms,pot

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15

Stenqvist, Ann-Christin. "Immunomodulation during human pregnancy : placental exosomes as vehicles of immune suppression." Doctoral thesis, Umeå universitet, Klinisk immunologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-87566.

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The mammalian pregnancy comprises a challenge to the maternal immune system since the fetus is semi-allogeneic and could thus be rejected. Pregnancy success is associated with the placenta that is not only essential for oxygen supply, nourishment and pregnancy hormones but also plays a role in the protection of the fetus against maternal immunologic attack. The aim of the current studies was to elucidate the role of human placenta as an immunomodulatory organ with a special focus on placental exosomes as vehicles for establishment of maternal tolerance to the fetus. We discovered that the sync

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16

Calvert, Sarah Joyce. "An investigation into the mechanisms of syncytial nuclear aggregate formation." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/an-investigation-into-the-mechanisms-of-syncytial-nuclear-aggregate-formation(5654b3eb-72fe-4e86-ba7b-e0574c70c27e).html.

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The outer surface of the human placenta, the syncytiotrophoblast, results from the fusion of many cytotrophoblast cells such that many nuclei are contained in this layer. It is possible for these nuclei to cluster forming syncytial nuclear aggregates (SNAs). SNAs have been linked to pathology with increased numbers and earlier formation of SNAs in preeclampsia and fetal growth restriction (FGR). SNAs can be grouped into subtypes including bridges, knots and sprouts, dependent on morphology and attachment to surrounding placental villi. Little is known about SNA formation, but the pyknotic appe

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17

Davey, Ashley. "The placenta as a viral reservoir: Implications for congenital cytomegalovirus infection." Master's thesis, 2011. http://hdl.handle.net/10048/1899.

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Human Cytomegalovirus (HCMV) is the most common cause of congenital infection in newborns. One mechanism for this virus to reach the fetus is to cross the placenta through the syncytiotrophoblast layer. Accumulation and protection of pathogens in the syncytiotrophoblast could affect the systemic distribution of pathogens and prolong maternal infections leading to increased incidence of fetal infections. Primary infections, reactivation or reinfection with another strain during pregnancy are risk factors for intrauterine HCMV transmission to the fetus. All lead to an active infection; however,

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18

Oliveira, Da Conceiçao Aline. "Effet d'extraits de plantes médicinales sur la différenciation cellulaire et le transport du calcium par les cellules syncytiotrophoblaste-like humaines." Thèse, 2010. http://www.archipel.uqam.ca/3666/1/D1962.pdf.

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Les plantes médicinales sont une importante source thérapeutique partout dans le monde. Leur consommation repose pour une bonne part sur la croyance populaire voulant que les produits qui en sont dérivés puissent être consommés en toute sécurité. Cependant, les études portant sur les propriétés phytochimiques ou biologiques de plusieurs produits végétaux ont démontré l'action et le potentiel toxique de ces produits sur les systèmes cellulaires des mammifères. Par ailleurs, la consommation de métabolites végétaux pendant la grossesse est peu étudiée et on ne connaît pas l'action de ces produits

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