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Academic literature on the topic 'Synclia'

Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Synclia"

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Salles, Lise, Mary Ford, Philippe Joseph, Christian Le Carlier De Veslud, and Antoine Le Solleuz. "Migration of a synclinal depocentre from turbidite growth strata: the Annot syncline, SE France." Bulletin de la Société Géologique de France 182, no. 3 (May 1, 2011): 199–220. http://dx.doi.org/10.2113/gssgfbull.182.3.199.

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AbstractThe Annot Sandstone turbidites of the Alpine foreland basin in SE France (Eocene-Oligocene: 40-32 Ma), provide an excellent case-study of tectono-sedimentary relations in a deepwater compressional system. The Annot outlier is a synclinal remnant previously interpreted as a static depocentre. A multi-disciplinary approach including geometrical and kinematic analyses and modelling demonstrates instead that this was a tectonically active turbidite depocentre where gentle thrust related folding controlled turbidite architecture.Stratigraphic and new structural field data are integrated with previous sedimentological studies to build a 3D geometric model of the Annot depocentre. Derived thickness maps associated with paleocurrent measurements clearly illustrate three main phases in the evolution of depocentre topography. (1) Early turbidite flows were mainly trapped by oblique intrabasinal inherited structures. (2) Once these structures were buried, the NNW-SSE active syncline constituted the main topographic control. (3) Decreasing activity of this syncline is recorded by filling and flow bypass. The progressive stages of the accepted depositional model (flow ponding, flow stripping and flow bypass), for the Annot depocentre, may therefore have a tectonic origin.The kinematic evolution of the synclinal depocentre was defined at different scales. Stratigraphic architecture records a decrease in bedding dips up through the turbidite succession on the western synclinal limb. Comparison with idealized case studies of the interaction of sedimentation with an active syncline indicates that this geometrical pattern corresponds to progressive westward migration of the synclinal hinge and depocentre. This tends to promote lateral rather than vertical stacking of sand bodies during turbidite sedimentation. Trishear kinematic modelling was used to simulate (in 2D) the rolling synclinal hinge. Stratigraphic surface geometries and turbidite depocentre migration define thrust and fold geometries at depth. The synclinal depocentre developed between two alternating or coeval fault propagation anticlines that exploited two detachment levels (Triassic evaporites and Cenomanian marls) in the underlying succession.
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Ge, Xu, Dameng Liu, Yidong Cai, and Yingjin Wang. "Gas Content Evaluation of Coalbed Methane Reservoir in the Fukang Area of Southern Junggar Basin, Northwest China by Multiple Geophysical Logging Methods." Energies 11, no. 7 (July 17, 2018): 1867. http://dx.doi.org/10.3390/en11071867.

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To study the gas potential of coalbed methane (CBM) in the Fukang area, southern Junggar Basin (SJB) of North China, different methods including multiple geophysical logging, the Kim method with proximate analysis data, and Langmuir adsorption were used to evaluate the gas content. Furthermore, the geological controls on gas content were evaluated. One hundred sixteen CBM wells with geophysical logging and 20 with field-measured gas content were adopted to assess the gas content in the Fukang area of SJB, NW China. The results show that the two geophysical logging variables (DEN and CNL) were favorable for evaluating the gas content due to the perfect correlation with the measured gas content. The gas content varies from 4.22 m3/t to 16.26 m3/t, and generally increases with increasing burial depth. The gas content in coal seams along the synclinal axis is significantly higher than that along the synclinal wing in the west zone. In the east zone, the gas content of the westward is higher than that of the eastward because of the fault coating effect by reverse fault. Generally, the gas content of the SJB is in the order of syncline > surrounding reverse fault > slope of syncline > slope of anticline > central of reverse fault, if only geological structure features are considered. The favorable areas for CBM concentration appear to be a composite gas controlling result of multiple geological factors. Two typical geological scenarios with low gas content and high gas content were revealed. In the Fukang area of SJB, the low gas content is mainly due to the normal fault and roof lithology of sandstone. The most favorable area of high gas content for CBM exploration and development is in the northeast, where reversed fault, synclinal axis, mudstone roof lithology, and burial depth coincide with high gas content.
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Roma, Maria, Oskar Vidal-Royo, Ken McClay, Oriol Ferrer, and Josep Anton Muñoz. "Tectonic inversion of salt-detached ramp-syncline basins as illustrated by analog modeling and kinematic restoration." Interpretation 6, no. 1 (February 1, 2018): T127—T144. http://dx.doi.org/10.1190/int-2017-0073.1.

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Salt-detached ramp-syncline basins are developed in extensional settings and are characterized by wide synclinal sedimentary basins detached on salt and formed above the hanging wall of active ramp-flat-ramp extensional faults. They are rarely fault bounded; instead, they are bounded by salt structures that are in general parallel to the major subsalt structures. As such, the formation of these extensional systems requires the presence of (1) a subsalt extensional fault with significant dip changes and (2) an evaporitic unit above the extensional fault, which partially or completely decouples the basin from a subsalt extensional fault. Salt-detached ramp-syncline basins have a significant exploration potential when their extensional geometry is preserved and when they have undergone positive tectonic inversion and consequent uplift and fold amplification. However, in some cases, their subsalt geometry may not be fully recognizable, especially when subsalt seismic imaging is poor. To obtain a deeper understanding of the geometry and kinematic evolution of these salt-detached ramp-syncline basins, we performed a series of analog modeling experiments, in which the models’ cross sections had been sequentially restored. Analog models and restoration results reveal that the kinematic evolution of the salt-detached ramp-syncline basins during extension and inversion depends on the interaction of different factors that may function simultaneously. Our results are used to improve the interpretation of seismic sections in inverted Mesozoic salt-detached ramp-syncline basins on the Atlantic margins, where subsalt faults are not well-imaged, and thus the suprasalt geometries must be used to infer the subsalt structure.
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Ford, M., and J. Vergés. "Evolution of a salt-rich transtensional rifted margin, eastern North Pyrenees, France." Journal of the Geological Society 178, no. 1 (September 4, 2020): jgs2019–157. http://dx.doi.org/10.1144/jgs2019-157.

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In this field study we reinterpret the narrow eastern North Pyrenean Zone, France, as an inverted salt-rich transtensional rift system based on identification of halokinetic depositional sequences across rift platform to distal rift margin domains with a cumulative throw of >2.8 km on steep Cretaceous faults. The rift platform records extension on detached rotational faults above Triassic evaporites from Jurassic to Aptian with uplift and erosion during the Albian. Transtensional Aptian–Albian minibasins align along the salt-rich rift margin fault zone. In the Aptian–Albian main rift large en echelon synclinal minibasins developed between salt walls, although Jurassic diapiric evolution is likely. Upper Cretaceous units locally record continuing diapirism. The Boucheville and Bas Agly depocentres, altered by synrift HT metamorphism, form the distal rift domain terminating south against the North Pyrenean Fault. The narrowness of the Pyrenean rift, shape of minibasins, en echelon oblique synclinal depocentres and folds coupled with a discontinuous distribution and intensity of HT metamorphism support a transtensional regime along the Iberia–Europe plate margin during late Early and early Late Cretaceous. In this model, the distal European margin comprises deep faults limiting laterally discontinuous crustal domains and ‘hot’ pull-apart basins with mantle rocks directly beneath sedimentary cover.Supplementary material: A table summarizing the stratigraphy of the NE Pyrenees and an interpreted Google Earth view of the Quillan syncline and minibasin are available at https://doi.org/10.6084/m9.figshare.c.5100036
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Vu, Ly P., Camila Prieto, Elianna Amin, Gerard Minuesa, Sagar Chhangawala, Maria J. Vidal, Andrei V. Krivtsov, et al. "RNA Binding Protein Syncrip Regulates the Leukemia Stem Cell Program." Blood 128, no. 22 (December 2, 2016): 739. http://dx.doi.org/10.1182/blood.v128.22.739.739.

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Abstract RNA binding proteins (RBPs) tightly control mRNA abundance, stability and translation while mutations or altered expression of specific factors can drive malignancy. Yet, the identity of the RBPs that govern myeloid stem cells remains poorly characterized. We and others have recently demonstrated that MUSASHI-2 (MSI2) is a central regulator of the cancer stem cell program in myeloid leukemia. Therefore, we curated a list of 127 MSI2 direct protein interactors and associated genes to perform an in vivo shRNA screen using MLL-AF9 leukemia cells. We identified shRNAs corresponding to 24 genes that were significantly depleted in vivo after sequencing and comparing their representation from day 16 to day 0. We confirmed knockdown and demonstrated marked reduction in myeloid colony formation in vitro after depleting 7 hits identified in our screen. Additionally, we tested these genes in normal bone marrow c-Kit positive cells and found that the most differentially required gene in leukemia cells compared to normal cells was SYNCRIP (Synaptotagmin-binding, cytoplasmic RNA-interacting protein). SYNCRIP is an RNA binding protein that has been implicated in various RNA regulatory processes but its role in the hematopoietic system is virtually unknown. Depletion of SYNCRIP with shRNAs in murine MLL-AF9 leukemia cells resulted in an increase in myeloid differentiation, apoptosis and delayed leukemogenesis in vivo (median survival of 35 days; control versus 61 days shRNA#1 knockdown was selected against, and "not reached" shRNA#2). To further assess SYNCRIP function in vivo, we developed a germline Syncrip knockout (KO) by injecting Cas9-DNA and Syncrip - guides RNAs into embryos and harvested E13 fetal liver cells. After Syncrip deletion was verified by immunoblotting, we observed normal numbers of HSCs and equivalent engraftment in lethally irradiated animals in both primary and secondary transplants. In contrast, we observed a delay in leukemeogenesis (median survival of 87.5 days; WT versus 118 days KO) in recipient mice after transplantation of MLL-AF9 transformed LSKs. Notably, non-deleted leukemia cells outcompeted the SYNCRIP deleted cells based on a reemergence of SYNCRIP expression. These data suggest that SYNCRIP is differentially required in myeloid leukemia cells compared to normal cells. Furthermore, we found that SYNCRIP was highly expressed in wide variety of human AML cell lines and in primary AML patients (n=4/5). SYNCRIP depletion with shRNAs resulted in reduced cell proliferation and the induction of apoptosis in human AML cell lines (MOLM13, NOMO-1, KASUMI-1 and NB4) and a marked decrease in engraftment of primary AML patient cells. To gain insights into SYNCRIP function, we performed RNA-sequencing of leukemia cells depleted for SYNCRIP. Gene set enrichment analysis (GSEA) negatively enriched for the MLL-AF9, HOXA9 and stem cell programs in SYNCRIP-KD cells and positively enriched for MSI2's direct mRNA binding targets and a MSI2 deficient LSC signature. Reciprocal immunoblotting in the presence or absence of RNAse demonstrated that SYNCRIP and MSI2 interaction is RNA dependent. We validated their shared targets by performing SYNCRIP RNA-immunoprecipitation (RIP) for previously identified MSI2's direct mRNAs targets (HOXA9 and c-MYC). SYNCRIP depletion resulted in reduced protein abundance of HOXA9 and c-MYC. Forced MSI2 expression partially rescued the colony formation and HOXA9 expression in SYNCRIP-KD cells. To assess the functional downstream targets of SYNCRIP in leukemia, we overexpressed HOXA9 and c-MYC in SYNCRIP-KD cells and observed that HOXA9 expression but not c-MYC partially rescues the effect of SYNCRIP depletion on myeloid colony formation. Mechanistically, we showed that SYNCRIP regulates translation of HOXA9 without affecting HoxA9 mRNA stability. Overall, we provide a strategy for interrogating the functional RNA binding network in leukemia using shRNA screening. Additionally, we validated SYNCRIP as a novel RBP that controls the leukemia stem cell program and propose that targeting these functional complexes might provide a novel therapeutic strategy in myeloid leukemia. Disclosures Melnick: Janssen: Research Funding. Levine:Novartis: Consultancy; Qiagen: Membership on an entity's Board of Directors or advisory committees. Järås:Cantargia AB: Equity Ownership.
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Grube, Martin, and Anders Tehler. "Syncesia (Arthoniales, Euascomycetidae)." Bryologist 102, no. 3 (1999): 573. http://dx.doi.org/10.2307/3244239.

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Mela, Alexander P., Adriana M. Rico-Ramírez, and N. Louise Glass. "Syncytia in Fungi." Cells 9, no. 10 (October 8, 2020): 2255. http://dx.doi.org/10.3390/cells9102255.

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Filamentous fungi typically grow as interconnected multinucleate syncytia that can be microscopic to many hectares in size. Mechanistic details and rules that govern the formation and function of these multinucleate syncytia are largely unexplored, including details on syncytial morphology and the regulatory controls of cellular and molecular processes. Recent discoveries have revealed various adaptations that enable fungal syncytia to accomplish coordinated behaviors, including cell growth, nuclear division, secretion, communication, and adaptation of the hyphal network for mixing nuclear and cytoplasmic organelles. In this review, we highlight recent studies using advanced technologies to define rules that govern organizing principles of hyphal and colony differentiation, including various aspects of nuclear and mitochondrial cooperation versus competition. We place these findings into context with previous foundational literature and present still unanswered questions on mechanistic aspects, function, and morphological diversity of fungal syncytia across the fungal kingdom.
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Filipecki, Marcin, Marek Żurczak, Mateusz Matuszkiewicz, Magdalena Święcicka, Wojciech Kurek, Jarosław Olszewski, Marek Daniel Koter, Douglas Lamont, and Mirosław Sobczak. "Profiling the Proteome of Cyst Nematode-Induced Syncytia on Tomato Roots." International Journal of Molecular Sciences 22, no. 22 (November 10, 2021): 12147. http://dx.doi.org/10.3390/ijms222212147.

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Cyst nematodes are important herbivorous pests in agriculture that obtain nutrients through specialized root structures termed syncytia. Syncytium initiation, development, and functioning are a research focus because syncytia are the primary interface for molecular interactions between the host plant and parasite. The small size and complex development (over approximately two weeks) of syncytia hinder precise analyses, therefore most studies have analyzed the transcriptome of infested whole-root systems or syncytia-containing root segments. Here, we describe an effective procedure to microdissect syncytia induced by Globodera rostochiensis from tomato roots and to analyze the syncytial proteome using mass spectrometry. As little as 15 mm2 of 10-µm-thick sections dissected from 30 syncytia enabled the identification of 100–200 proteins in each sample, indicating that mass-spectrometric methods currently in use achieved acceptable sensitivity for proteome profiling of microscopic samples of plant tissues (approximately 100 µg). Among the identified proteins, 48 were specifically detected in syncytia and 7 in uninfected roots. The occurrence of approximately 50% of these proteins in syncytia was not correlated with transcript abundance estimated by quantitative reverse-transcription PCR analysis. The functional categories of these proteins confirmed that protein turnover, stress responses, and intracellular trafficking are important components of the proteome dynamics of developing syncytia.
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Joffe, BI, IV Solovei, KB Sewell, and LRG Cannon. "Organization of the Epidermal Syncytial Mosaic in Diceratocephala-Boschmai (Temnocephalida, Platyhelminthes)." Australian Journal of Zoology 43, no. 5 (1995): 509. http://dx.doi.org/10.1071/zo9950509.

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The epidermis of Diceratocephala boschmai Baer, 1952 (Temnocephalida : Platyhelminthes) was studied using silver-nitrate staining and electron microscopy. The epidermis consists of six syncytia separated by lateral membranes: the frontal, trunk, stalk, adhesive disc syncytia, and a pair of post-tentacular syncytia. Neighbouring syncytia differ in many characters including (1) the presence or absence of locomotory cilia, (2) the degree of the differentiation of the apical cytoplasm layer, (3) the presence or absence of bundles of cytoskeletal filaments, imaginations of basal membrane and other specialised cytoplasmatic structures, (4) the abundance of hemidesmosomes at the basal membrane, and (5) the abundance and nature of gland ducts penetrating the syncytium. These structural differences reflect functional differences between the syncytia. Thus, multisyncytial organisation of the epidermis may be explained by functional differences between the syncytia. Only between the frontal and trunk syncytia has no apparent ultrastructural difference been found.
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Sylwester, A., D. Wessels, S. A. Anderson, R. Q. Warren, D. C. Shutt, R. C. Kennedy, and D. R. Soll. "HIV-induced syncytia of a T cell line form single giant pseudopods and are motile." Journal of Cell Science 106, no. 3 (November 1, 1993): 941–53. http://dx.doi.org/10.1242/jcs.106.3.941.

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The human immunodeficiency virus, HIV, induces syncytium formation in cultures of many T cell lines. These syncytia have previously been viewed as disorganized fusion products in the throes of death. Evidence is presented that in HIV1-infected SupT1 cultures, syncytia five times to over one hundred times larger than single cells organize their many nuclei into blastula-like balls, reorganize their cytoskeleton to mimic that of a single cell, and extend single, giant pseudopods in a polar fashion. Medium-sized syncytia are capable of translocation through extension of these giant pseudopods. The rate of translocation of syncytia is comparable to that of single cells. Single cell motility, syncytium motility and pseudopod extension also appear to play roles in the recruitment of cells into syncytia. Finally, condensation of F-actin at cell-syncytium and syncytium-syncytium adhesion sites suggests the involvement of the cytoskeleton in the adhesion and/or subsequent fusion event. These results suggest that the fusion events involved in HIV-induced syncytia formation involve both cell motility and reorganization of the cytoskeleton, and demonstrate that syncytia are highly organized, motile entities.
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Dissertations / Theses on the topic "Synclia"

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Mulloy, Rory. "Identification of Transmembrane and Extracellular Host Proteases that Promote Human CoV Entry and Syncytium Formation." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42673.

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Claviere, Mathieu. "Étude de l'autophagie lors d'une co-infection par le virus de la rougeole et Salmonella typhimurium." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSEN011.

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Le virus de la rougeole est un agent pathogène responsable d’immunosuppressions transitoires mais sévères chez les individus infectés. L’infection par ce virus peut ainsi mener à l’établissement d’infections secondaires opportunistes, souvent décrites chez les patients rougeoleux. Cependant, la contribution du virus de la rougeole sur des infections secondaires à l’échelle de la cellule co-infectée n’a jamais fait l’objet d’études. Notre équipe à précédemment démontré que le virus de la rougeole induit une autophagie productive dans les cellules infectées, requise pour une réplication optimale du virus. À l’opposé, certains pathogènes comme la bactérie Salmonella typhimurium sont restreints par l’autophagie. Le but de cette thèse est d’étudier la contribution de l’autophagie sur la prolifération bactérienne en condition de co-infection avec le virus de la rougeole. Au cours du projet, nous avons identifié que dans les cellules co-infectées avec le virus de la rougeole, la bactérie Salmonella typhimurium hyperprolifère. Cette prolifération intense prend place essentiellement dans des cellules multinucléées géantes (syncytia) formées par le virus. En outre, la bactérie, normalement localisée dans une vacuole cellulaire, se localise dans le cytosol de ces syncytia et semble insensible à l’autophagie. Au cours de cette thèse, nous avons identifié que le facteur antimicrobien TBK1 pourrait être détourné par l’infection virale, contribuant ainsi à l’échappement de la bactérie à l’autophagie. Ce travail de thèse met ainsi en évidence une nouvelle possibilité d’échappement de bactéries à l’autophagie lors d’une co-infection virale
Measles virus is a pathogenic agent responsible for transient but severe immunosuppression in infected individuals. The infection can lead to the establishment of secondary infections, frequently described in measles virus infected patients. Nevertheless, Measles virus contribution to secondary infection at cell scale level have never been studied yet. Our team has previously described that Measles virus induce a fully functional autophagy in infected cells, which is mandatory for an efficient viral replication. On the opposite, some pathogens, as the bacteria Salmonella typhimurium are restricted by autophagy. The aim of this PhD project is to study the contribution of autophagy on bacterial proliferation upon Measles virus co-infection at cell level. During this project, we have identified that in Measles virus coinfected cells, Salmonella typhimurium hyperproliferates. This exacerbated proliferation takes place in multinucleated giant cells induced by the virus, which are called syncytia. In addition, the bacteria, which is normally localized in cellular vacuole, is localized directly inside the cytosol of syncytia. Furthermore, cytosolic bacteria appears to be insensitive to autophagy. During this PhD project, we have identified that the cellular factor TBK1 could be hijack by the viral infection. Thus, this could allow the auophagic escape of the bacteria. This study highlight a new opportunity of autophagic escape of bacteria during a viral co-infection
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Zhang, Li. "The cell wall microstructures of syncytia induced by cyst nematodes." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/16153/.

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Plant parasitic cyst nematodes induce the formation of specialised feeding structures, termed syncytia, from which they feed within the host roots. The multinucleate syncytium initiates from a single host root cell and expands by the local cell wall dissolution of neighbouring cells. In this study, a set of monoclonal antibodies were applied to reveal the microstructures of syncytial cell walls induced by four economically important cyst nematode species, Globodera pallida, Heterodera glycines, Heterodera avenae and Heterodera filipjevi, in their respective potato, soybean and wheat host roots. In situ fluorescence analysis revealed that cell walls of syncytia induced by G. pallida and H. glycines share high structural similarity. Both consisted of abundant xyloglucans, methyl-esterified homogalacturonan and pectic arabinans. In contrast, the walls of syncytia induced in wheat roots by H. avenae and H. filipjevi contain much less xyloglucan but are rich in feruloylated and substituted heteroxylans and arabinans, with variable levels of mixed-linkage glucans and galactans. Further investigations were implemented using a range of cell wall related Arabidopsis xyloglucan and pectic arabinan mutants. In situ analysis was applied on those H. schachtii induced syncytia. The results indicated the strong adaptions during the induction and formation of the syncytia while the cell wall composition of the syncytium was stable. Besides, the syncytial wall pectin methyl-esterification status was shown to fluctuate along with the syncytium development in addition to coping with induced PEG-simulated drought stress. Further analysis was carried out on selected pectic homogalacturonan related mutants, and the fluorescence-based quantifications revealed the complexity of the forming and regulating pectin methyl esterification. Transgenic wheat lines with a root-cap-specific promoter were made via biolistics, in the hope of using this system to further investigate the syncytia formed in wheat, which were shown to be different from the other syncytia analysed.
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Lacek, William Joseph. "Fluid History of the Sideling Hill Syncline, Hancock County, Maryland." Bowling Green State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1435009185.

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Leys, Sally P. "Cytoskeletal architecture, organelle transport, and impulse conduction in hexactinellid sponge syncytia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0007/NQ32755.pdf.

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Reilly, Mark Robert William. "Deepwater reservoir analogue - bunkers sandstone, donkey bore syncline, Flinders Ranges Australia /." Title page, abstract and contents only, 2001. http://web4.library.adelaide.edu.au/theses/09SB/09sbr362.pdf.

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Halstead, James Maximilian. "Syncrip regulates mRNA localisation and translation at the Drosophila neuromuscular junction." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:5e9040a3-a9d3-40e9-adf6-d9dae0e9ec09.

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Evidence in different systems suggests that local translation is involved in synaptic plasticity in both neuron and muscle, but the mechanism by which this occurs is still poorly understood. The mRNA-binding protein Syncrip is conserved from fly to mammals and is thought to be involved in localized translation in both oocytes and neurons. Previous work has shown that Syncrip associates with mRNAs encoding key synaptic proteins at the Drosophila larval neuromuscular junction. Here I show that Syncrip is necessary for the structure and function of the neuromuscular junction. First, the loss of Syncrip leads to overgrowth of the neuromuscular junction. Second, Syncrip is required for proper expression of the Ca2+-sensor Synaptotagmin1 at the presynapse, and loss of Syncrip causes a decrease in vesicle release probability. Third, while it was not possible to measure mRNA distribution in neurons, Syncrip mutants, like other perturbations in synaptic plasticity, correlate with changes in mRNA localization in muscle. Fourth, the overexpression and loss of Syncrip function suggest that the nuclear and nucleolar trafficking of the eukaryotic translation initiation factor eIF4E may be important to regulating synaptic morphology. These data suggest that Syncrip is involved in mRNA localization and translation in synaptic plasticity.
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Lan, Yan. "Membrane fusion proteins associated with the surface synctial epithelium of Schistosoma mansoni." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0007/MQ42078.pdf.

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MERMET, MOUTTET MARIE-PAULE. "Une approche synthetique de la terpestacine, un inhibiteur de formation de syncytia." Université Louis Pasteur (Strasbourg) (1971-2008), 1997. http://www.theses.fr/1997STR13247.

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Nous avons etudie la synthese totale de la terpestacine, un sesterterpene bicyclique isole en 1993 et qui n'a jamais ete synthetise. Notre approche impliquait d'une part la synthese d'un beta-cetophosphonate acyclique a partir de la 6-methylhept-5-en-2-one et d'autre part l'obtention d'un intermediaire cyclopentanique optiquement actif - portant quatre substituants alkyle et une alphadicetone - a partir du (-)-endo-3-bromocamphre. Apres plusieurs tentatives infructueuses, nous sommes parvenus a obtenir la partie acyclique en grande quantite, grace a la variante johnson du rearrangement de claisen. L'obtention d'une partie cyclopentanique incompletement substituee a ete moins difficile, bien qu'il ait fallu d'abord se familiariser avec la chimie de l'endo-3-bromocamphre decrite anterieurement par t. Money (nous avons utilise ici l'enantiomere dextrogyre moins onereux). Une reaction de horner-wadsworth-emmons a permis la connexion des parties acyclique et cyclopentanique par une double liaison trans. Puis la macrocyclisation a ete tentee par une reaction de mcmurry (procedure de furstner) qui a probablement donne une petite quantite de produit attendu, mais qui devra encore etre considerablement amelioree. Parallelement a ces travaux, nous avons egalement etudie la fonctionnalisation de la partie cyclopentanique sur laquelle nous avons reussi a introduire le motif alpha-dicetone. Enfin, nous avons ebauche une deuxieme approche du squelette de la terpestacine a partir de trois precurseurs qui doit culminer dans l'utilisation d'un organobaryen allylique.
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Dickey, Laura Leigh. "Respiratory synctial virus interactions with host-cell RNA-processing structures and proteins." Thesis, Boston University, 2013. https://hdl.handle.net/2144/10980.

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Thesis (Ph.D.)--Boston University
Respiratory syncytial virus (RSV) is a negative-strand RNA virus that causes significant pneumonia-related morbidity and mortality worldwide. There are currently neither vaccines nor effective therapies for RSV. As with other viruses, RSV mRNAs are translated using host-cell machinery, rendering the virus subject to cellular factors that regulate mRNA homeostasis. Stress granules (SGs) and processing bodies (p-bodies) are inter-dependent, stress-response cytoplasmic structures involved in mRNA triage and degradation, respectively. We hypothesized that RSV has evolved to manipulate cellular stress responses in order to facilitate optimal virus propagation. While wild-type (wt) RSV induced SGs in approximately 1% of infected cells, a mutant version of RSV whose Tr region was replaced with an inverted LeC sequence (LeC virus) induced SG formation in approximately 50% to 70% of infected cells. A 12U to A substitution relative to the 5' end of the LeC virus abrogated SG induction. Mixed-infection studies showed that wt RSV was able to prevent LeC-mediated SG induction. Unlike Sendai virus, RSV-mediated prevention of SG formation was independent of SG-associated t-cell intracellular antigen related (TIAR) protein. RSV infection altered neither the number nor distribution of p-bodies; however, p-body-associated decapping protein 1 (dcp1) was phosphorylated throughout RSV infection via the extracellular signal-regulated kinase (ERK) 1/2 pathway. RSV-mediated dcp1 phosphorylation was limited to serine 315, serine 319, and threonine 321. Dcp1 phosphorylation occurred in response to some, but not all, environmental stresses, and dcp1 was not phosphorylated during infection with HIV-1, measles, mumps, or canine distemper virus. Overexpression of dcp1 significantly attenuated RSV cytopathic effects, and preliminary data suggested that dcp1 phosphorylation regulated RSV-induced interleukin-8 production. Finally, an antibody toward cellular SG- and p-body-associated, RNA-binding protein p54 was able to recognize a subset of RSV nucleoprotein (N). p54 and RSV N contain a similar amino acid sequence motif, suggesting that they may have similar or competing activities that are important during RSV replication. Taken together, our results demonstrate that RSV can manipulate cellular RNA-processing structures and proteins to facilitate viral propagation.
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Books on the topic "Synclia"

1

Tehler, Anders. Syncesia (Arthoniales, Euascomysetidae). New York: Published for Organization for Flora Neotropica by the New York Botanical Garden, 1997.

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Callahan, James E. Deadfall Syncline coal: Quality and reserves. Fairbanks, Alaska: Mineral Industry Research Laboratory, University of Alaska Fairbanks, 1992.

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Gilpin, Edwin. The southern synclinal of the Pictou coal field. [S.l: s.n., 1985.

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Liew, William P. Van. Hydrology of the Hart Syncline area, northwestern Colorado. Denver, Colo: U.S. Dept. of the Interior, U.S. Geological Survey, 1993.

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Liew, William P. Van. Hydrology of the Hart Syncline area, northwestern Colorado. Denver, Colo: U.S. Dept. of the Interior, U.S. Geological Survey, 1993.

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Liew, William P. Van. Hydrology of the Hart Syncline area, northwestern Colorado. Denver, Colo: U.S. Dept. of the Interior, U.S. Geological Survey, 1993.

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Palaeontology and facies of the late Famennian in the Paffrath Syncline (Rhenish Massif, Germany). Stuttgart: Schweizerbart'sche Verlagsbuchhandlung, 2004.

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Lawinski, C. P. An evaluation of the Philips medical systems angio diagnost 5 syncra tilting table: (formerly AD6 X-ray table). London: Department of Health, Medical Devices Agency, 1996.

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Chaplet, Michel. Etude géologique du massif subalpin des Bornes (Haute-Savoie): Relations structurales entre unité des Aravis et Bornes externes dans le synclinal de Nappes de Thône. Chambéry [France]: Université de Savoie, 1989.

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Synclair. Bella Books, 2020.

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Book chapters on the topic "Synclia"

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Golinowski, Wladyslaw, Miroslaw Sobczak, Wojciech Kurek, and Grazyna Grymaszewska. "The Structure of Syncytia." In Developments in Plant Pathology, 80–97. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5596-0_7.

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Alania, V., A. Chabukiani, O. Enukidze, K. Gogrichiani, Z. Mikeladze, and G. Tatishvili. "Didigori Syncline and Anticline." In Atlas of Structural Geological Interpretation from Seismic Images, 141–42. Chichester, UK: John Wiley & Sons, Ltd, 2018. http://dx.doi.org/10.1002/9781119158332.ch26.

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Sobczak, Miroslaw, and Wladyslaw Golinowski. "Cyst Nematodes and Syncytia." In Genomics and Molecular Genetics of Plant-Nematode Interactions, 61–82. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-0434-3_4.

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Eisenback, Jonathan D. "Staining chromosomes." In Techniques for work with plant and soil nematodes, 195–205. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781786391759.0195.

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Eisenback, Jonathan D. "Staining chromosomes." In Techniques for work with plant and soil nematodes, 195–205. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781786391759.0010.

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Al-Azzawi, Nabeel K., and Myasar S. Al-Saraj. "Dohuk Syncline as an Artificial Recharge Aquifer, Northern Iraq." In Recent Advances in Environmental Science from the Euro-Mediterranean and Surrounding Regions, 695–98. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-70548-4_206.

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Wang, Yan, and Martine Culty. "Preparation of Enriched Mouse Syncitia-Free Pachytene Spermatocyte Cell Suspensions." In Methods in Molecular Biology, 67–74. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-61779-436-0_6.

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Pribil, K., Ch Serbe, B. Wandernoth, and Ch Rapp. "Solacos YAG Communication System-YKS Implementation of the Syncbit-Concept." In Laser in der Technik / Laser in Engineering, 765–71. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-662-08251-5_165.

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Harris, J. R. "Ultrastructural Changes in Nuclei Within HIV-1-Induced Cultured Cell Syncytia." In Nuclear Structure and Function, 483–87. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-0667-2_99.

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Kim, Jonathan S., and Paul E. Green. "Replicated Weights Determination in the Synclus Optimal Variable Weights Clustering Procedure." In Proceedings of the 1993 Academy of Marketing Science (AMS) Annual Conference, 350–54. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-13159-7_80.

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Conference papers on the topic "Synclia"

1

Durkowski, Karol. "INFLUENCE OF 2D SEISMIC REFLECTION SURVEYING ON PRECISION OF SYNCLINAL STRUCTURES GEOLOGICAL IDENTIFICATION � AN EXAMPLE FROM THE GRODZIEC SYNCLINE, NORTH SUDETIC SYNCLINORIUM (POLAND)." In 19th SGEM International Multidisciplinary Scientific GeoConference EXPO Proceedings. STEF92 Technology, 2019. http://dx.doi.org/10.5593/sgem2019/1.1/s01.032.

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Sotnikov, Oleg, Svetlana Sergeeva, and Dmitriy Mekhilainen. "SYNCYTIA OF THE ABDOMINAL BRAIN." In XVIII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2022. http://dx.doi.org/10.29003/m2940.sudak.ns2022-18/324-325.

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Ghossaini, Bassem M., Kazem Y. Dehaini, Mustafa A. Alruzz, Najib A. Fakhr Eddine, and Farook R. Hamzeh. "SyncLean: An Application for Improved Lean Construction Practice." In 26th Annual Conference of the International Group for Lean Construction. International Group for Lean Construction, 2018. http://dx.doi.org/10.24928/2018/0242.

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Ralbovsky, E., and P. Ostrolucky. "The Glinzendorf Syncline below the Vienna Basin in Slovakia." In 56th EAEG Meeting. European Association of Geoscientists & Engineers, 1994. http://dx.doi.org/10.3997/2214-4609.201410278.

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Osella, A. M., and P. Martinelli. "The Effects of Anisotropy on Synclinal and Anticlinal Structures." In 2nd International Congress of the Brazilian Geophysical Society. European Association of Geoscientists & Engineers, 1991. http://dx.doi.org/10.3997/2214-4609-pdb.316.75.

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Prischepa, O. M., A. M. Zharkov, and A. Kh Ibatullin. "Petroleum Prospects Mezen Syncline on Volume-Genetic Modeling Results." In Geomodel 2021. European Association of Geoscientists & Engineers, 2021. http://dx.doi.org/10.3997/2214-4609.202157106.

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Gu, Shitan, Bangyou Jiang, Ruifeng Huang, and Zhimin Xiao. "Evolution Characteristics of Rock Burst Danger Mining in Syncline Environment." In 9th China-Russia Symposium “Coal in the 21st Century: Mining, Intelligent Equipment and Environment Protection". Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/coal-18.2018.4.

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Fassina, Lorenzo, Antonio Di Grazia, Fabio Naro, Salvatore Aguanno, Marisa Cornacchione, Maria Gabriella Cusella De Angelis, Francesca Sardi, and Giovanni Magenes. "Effects of the hydrostatic pressure in in vitro beating cardiac syncytia in terms of kinematics (kinetic energy and beat frequency) and syncytia geometrical-functional classification." In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2013. http://dx.doi.org/10.1109/embc.2013.6609635.

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Tayebi, Arash, Setevan Berber, and Akshya Swain. "Syncim: A new impersonation attack against chip synchronization in WSN." In 2015 9th International Conference on Sensing Technology (ICST). IEEE, 2015. http://dx.doi.org/10.1109/icsenst.2015.7438377.

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Lamarche, J., B. D. M. Gauthier, G. Ondicolbery, D. Gallinier, J. Fleury, S. Viseur, M. Chavez, and S. Chatelée. "Fracture Corridors in Fold and Thrust Zone, Devonian Sandstones Icla Syncline (Bolivia)." In Third EAGE Workshop on Naturally Fractured Reservoirs. Netherlands: EAGE Publications BV, 2018. http://dx.doi.org/10.3997/2214-4609.201800022.

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Reports on the topic "Synclia"

1

Ryan, R. J. Geology of the Tatamagouche Syncline, Cumberland Basin, Nova Scotia. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1986. http://dx.doi.org/10.4095/130049.

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Kowall, Neil W. Alpha Synclein Aggreagation in a Neurotoxic Model of Parkinson's Disease. Fort Belvoir, VA: Defense Technical Information Center, August 2003. http://dx.doi.org/10.21236/ada423207.

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Ryan, R. J. Upper Carboniferous strata of the Tatamagouche Syncline, Cumberland Basin, Nova Scotia. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1985. http://dx.doi.org/10.4095/120279.

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LePain, D. L., N. T. Harun, and R. A. Kirkham. Measured stratigraphic section, lower Nanushuk Formation (Albian), Slope Mountain (Marmot syncline), Alaska. Alaska Division of Geological & Geophysical Surveys, December 2022. http://dx.doi.org/10.14509/30871.

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Soule, G. S., and D. A. Spratt. Study of the Triangle Zone and foothills structures in the Grease Creek syncline area of Alberta. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1992. http://dx.doi.org/10.4095/132838.

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Jackson, G. D. Bedrock geology, northwest part of Nuluujaak Mountain, Baffin Island, Nunavut, part of NTS 37-G/5. Natural Resources Canada/CMSS/Information Management, 2021. http://dx.doi.org/10.4095/314670.

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Abstract:
The map area lies about 40 km northwest of Baffinland's iron mine. Dykes of unit mAnA3 within unit mAnA2 suggest that unit mAnA2 predates unit mAnA3. Unit nAMqf, basal Mary River Group unit, includes regolith material from units mAnA2 and mAnA3. Unit mAnAm may include some dykes of unit nAMb. The Mary River Group was deposited in a volcanic-arc environment, yielding zircon U-Pb ages mostly in the range of 2.88 to 2.72 Ga. Iron-formation (unit nAMi) is approximately 276 m thick locally, with oxide facies (unit nAMio) being most abundant. The quartzite triangle west of 'Iron lake' (unofficial name) may be a small horst. The main east-west-trending synclinal fold, including the area around 'Iron lake' and the no. 4 ore deposit, is upright, nearly isoclinal, and plunges mostly easterly at both ends with small scale anticlines and synclines in the middle. Magnetite constitutes about 75% of high-grade iron deposits in the north limb, whereas hematite predominates in south-limb deposits. K-Ar and Rb-Sr ages indicate middle Paleoproterozoic overprinting. Central Borden Fault Zone was active at ca. 1.27 Ga and during or after Ordovician time. Note: please be aware that the information contained in CGM 408 is based on legacy data from the 1960-1990s and that it has been superseded by regional-scale information contained in CGM 403.
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Aeromagnetic total field map, Blake River Syncline, Ontario. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1993. http://dx.doi.org/10.4095/183885.

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Aeromagnetic total field map, Blake River Syncline, Ontario. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1993. http://dx.doi.org/10.4095/183886.

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Aeromagnetic total field map, Blake River Syncline, Ontario. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1993. http://dx.doi.org/10.4095/183887.

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Aeromagnetic total field map, Blake River Syncline, Ontario. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1993. http://dx.doi.org/10.4095/183888.

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