Journal articles on the topic 'Syk Inhibitor'
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Zhao, Xiaoxian, Andrew E. Schade, and Eric Hsi. "Distinct Role of Src Family Kinase Inhibitors in Burkitt Lymphoma Cells Vs. Diffuse Large B-Cell Lymphoma Cells." Blood 112, no. 11 (November 16, 2008): 3765. http://dx.doi.org/10.1182/blood.v112.11.3765.3765.
Full textMakhoul, Stephanie, Stephanie Dorschel, Stepan Gambaryan, Ulrich Walter, and Kerstin Jurk. "Feedback Regulation of Syk by Protein Kinase C in Human Platelets." International Journal of Molecular Sciences 21, no. 1 (December 25, 2019): 176. http://dx.doi.org/10.3390/ijms21010176.
Full textCoates, Matthew S., Eric W. F. W. Alton, Garth W. Rapeport, Jane C. Davies, and Kazuhiro Ito. "Pseudomonas aeruginosa induces p38MAP kinase-dependent IL-6 and CXCL8 release from bronchial epithelial cells via a Syk kinase pathway." PLOS ONE 16, no. 2 (February 1, 2021): e0246050. http://dx.doi.org/10.1371/journal.pone.0246050.
Full textWang, Xing, Junfang Guo, Zhongqi Ning, and Xia Wu. "Discovery of a Natural Syk Inhibitor from Chinese Medicine through a Docking-Based Virtual Screening and Biological Assay Study." Molecules 23, no. 12 (November 28, 2018): 3114. http://dx.doi.org/10.3390/molecules23123114.
Full textBertoni, Francesco, Andrea Rinaldi, Anna Sasso, Gianluca Gaidano, Emanuele Zucca, Silvia Uccella, Giancarlo Pruneri, et al. "In Vitro Activity of SYK and BCR-ABL Inhibitors in Aggressive Lymphomas." Blood 108, no. 11 (November 16, 2006): 2520. http://dx.doi.org/10.1182/blood.v108.11.2520.2520.
Full textBuchner, Maike, Simon Fuchs, Gabriele Prinz, Dietmar Pfeifer, Kilian Bartholomé, Nina Chevalier, Laurent Vallat, et al. "Spleen Tyrosine Kinase (SYK) Is Overexpressed and Represents a Potential Therapeutic Target in Chronic Lymphocytic Leukemia." Blood 112, no. 11 (November 16, 2008): 543. http://dx.doi.org/10.1182/blood.v112.11.543.543.
Full textYang, Na, Wei Deng, Qiaoling Sun, Junqing Liang, Linfang Wang, Shiming Fan, Renxiang Tang, et al. "HMPL-523, a Novel SYK Inhibitor Showed Anti-Tumor Activities In Vitro and In Vivo." Blood 128, no. 22 (December 2, 2016): 3970. http://dx.doi.org/10.1182/blood.v128.22.3970.3970.
Full textHuang, Duen-Yi, Wei-Yu Chen, Chi-Long Chen, Nan-Lin Wu, and Wan-Wan Lin. "Synergistic Anti-Tumour Effect of Syk Inhibitor and Olaparib in Squamous Cell Carcinoma: Roles of Syk in EGFR Signalling and PARP1 Activation." Cancers 12, no. 2 (February 19, 2020): 489. http://dx.doi.org/10.3390/cancers12020489.
Full textGetz, Todd M., Bhanu Manne, Lorena Buitrago, Yingying Mao, and Satya P. Kunapuli. "Dextran sulphate induces fibrinogen receptor activation through a novel Syk-independent PI-3 kinase-mediated tyrosine kinase pathway in platelets." Thrombosis and Haemostasis 109, no. 06 (2013): 1131–40. http://dx.doi.org/10.1160/th12-09-0645.
Full textIssara-Amphorn, Jiraphorn, Naraporn Somboonna, Prapaporn Pisitkun, Nattiya Hirankarn, and Asada Leelahavanichkul. "Syk inhibitor attenuates inflammation in lupus mice from FcgRIIb deficiency but not in pristane induction: the influence of lupus pathogenesis on the therapeutic effect." Lupus 29, no. 10 (July 22, 2020): 1248–62. http://dx.doi.org/10.1177/0961203320941106.
Full textRaeder, Evelin M. B., Pamela J. Mansfield, Vania Hinkovska-Galcheva, James A. Shayman, and Laurence A. Boxer. "Syk Activation Initiates Downstream Signaling Events During Human Polymorphonuclear Leukocyte Phagocytosis." Journal of Immunology 163, no. 12 (December 15, 1999): 6785–93. http://dx.doi.org/10.4049/jimmunol.163.12.6785.
Full textKiliszek, Przemyslaw, Maciej Szydlowski, Tomasz Sewastianik, Ewa Jablonska, Emilia Bialopiotrowicz, Patryk Gorniak, Anna Polak, et al. "FOXO1 Activation Is an Effector of SYK and AKT Inhibition in Tonic BCR Signal-Dependent Diffuse Large B-Cell Lymphomas." Blood 126, no. 23 (December 3, 2015): 314. http://dx.doi.org/10.1182/blood.v126.23.314.314.
Full textIssara-Amphorn, Jiraphorn, Wiwat Chancharoenthana, Peerapat Visitchanakun, and Asada Leelahavanichkul. "Syk Inhibitor Attenuates Polymicrobial Sepsis in FcgRIIb-Deficient Lupus Mouse Model, the Impact of Lupus Characteristics in Sepsis." Journal of Innate Immunity 12, no. 6 (2020): 461–79. http://dx.doi.org/10.1159/000509111.
Full textChen, Linfeng, Przemyslaw Juszczynski, Yasumichi Hitoshi, Wen Chen, Jeffery L. Kutok, and Margaret A. Shipp. "Tonic B-Cell Receptor Signaling Promotes the Survival of Diffuse Large B-Cell Lymphomas: Identification of SYK as a Rational Treatment Target." Blood 108, no. 11 (November 16, 2006): 226. http://dx.doi.org/10.1182/blood.v108.11.226.226.
Full textChen, Liguang, George Chen, Jessie-Farah Fecteau, Greg Coffey, Charles Prussak, Dennis A. Carson, and Thomas Kipps. "Highly Specific Inhibitor for Syk Induces Chronic Lymphocytic Leukemia Cell Apoptosis,." Blood 118, no. 21 (November 18, 2011): 3875. http://dx.doi.org/10.1182/blood.v118.21.3875.3875.
Full textHan, Yingjie, Frank Y. Ma, Julie Di Paolo, and David J. Nikolic-Paterson. "An inhibitor of spleen tyrosine kinase suppresses experimental crescentic glomerulonephritis." International Journal of Immunopathology and Pharmacology 32 (January 1, 2018): 205873841878340. http://dx.doi.org/10.1177/2058738418783404.
Full textAbraham, Shaji, Leonard C. Edelstein, Chad A. Shaw, Pierrette Andre, Xianguo Kong, Carol T. Dangelmaier, Alexander Tsygankov, Paul F. Bray, Satya P. Kunapuli, and Steven E. McKenzie. "Platelet FcγRIIA Signaling Results in Ubiquitination and Cellular Translocation of Activated Syk." Blood 124, no. 21 (December 6, 2014): 2761. http://dx.doi.org/10.1182/blood.v124.21.2761.2761.
Full textZhou, Zhou, Francisca C. Gushiken, Angela Bergeron, Vinod K. Vijayan, Rolando Rumbaut, Jose A. Lopez, and Jing-fei Dong. "STAT3 Regulates Collagen-Induced Platelet Aggregation Independent of Its Transcription Factor Activity." Blood 116, no. 21 (November 19, 2010): 157. http://dx.doi.org/10.1182/blood.v116.21.157.157.
Full textAbraham, Shaji, Carol T. Dangelmaier, Yuhang Zhou, Leonard C. Edelstein, Paul F. Bray, Satya P. Kunapuli, and Steven E. McKenzie. "Syk Is Regulated Downstream Of FcγRIIA In Platelets By Transient Tyrosine Phosphorylation and Ubiquitylation." Blood 122, no. 21 (November 15, 2013): 4737. http://dx.doi.org/10.1182/blood.v122.21.4737.4737.
Full textPamuk, Omer Nuri, Peter H. Lapchak, Poonam Rani, Polly Pine, Jurandir J. Dalle Lucca, and George C. Tsokos. "Spleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusion." American Journal of Physiology-Gastrointestinal and Liver Physiology 299, no. 2 (August 2010): G391—G399. http://dx.doi.org/10.1152/ajpgi.00198.2010.
Full textBiagioli, Michele, Andrea Mencarelli, Adriana Carino, Sabrina Cipriani, Silvia Marchianò, Chiara Fiorucci, Annibale Donini, et al. "Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases." Inflammatory Bowel Diseases 24, no. 1 (December 19, 2017): 123–35. http://dx.doi.org/10.1093/ibd/izx031.
Full textLauvrak, Silje Ugland, Sébastien Wälchli, Tore-Geir Iversen, Hege Holte Slagsvold, Maria Lyngaas Torgersen, Bjørn Spilsberg, and Kirsten Sandvig. "Shiga Toxin Regulates Its Entry in a Syk-dependent Manner." Molecular Biology of the Cell 17, no. 3 (March 2006): 1096–109. http://dx.doi.org/10.1091/mbc.e05-08-0766.
Full textSender, Sina, Ahmad Wael Sultan, Daniel Palmer, Dirk Koczan, Anett Sekora, Julia Beck, Ekkehard Schuetz, et al. "Evaluation of the Synergistic Potential of Simultaneous Pan- or Isoform-Specific BET and SYK Inhibition in B-Cell Lymphoma: An In Vitro Approach." Cancers 14, no. 19 (September 27, 2022): 4691. http://dx.doi.org/10.3390/cancers14194691.
Full textHatton, Olivia L., Stacie Lambert, Maria Vaysberg, Sheri M. Krams, Carlos O. Esquivel, and Olivia M. Martinez. "Syk, a novel therapeutic target for PTLD, drives Epstein Barr Virus B cell lymphoma growth and survival through the PI3K/Akt pathway (141.23)." Journal of Immunology 182, no. 1_Supplement (April 1, 2009): 141.23. http://dx.doi.org/10.4049/jimmunol.182.supp.141.23.
Full textWoulfe, Donna S. "A Syk inhibitor for sick platelets?" Blood 113, no. 14 (April 2, 2009): 3133–34. http://dx.doi.org/10.1182/blood-2009-01-199778.
Full textTümmler, Conny, Gianina Dumitriu, Malin Wickström, Peter Coopman, Andrey Valkov, Per Kogner, John Inge Johnsen, Ugo Moens, and Baldur Sveinbjörnsson. "SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro." Cancers 11, no. 2 (February 10, 2019): 202. http://dx.doi.org/10.3390/cancers11020202.
Full textHoellenriegel, Julia, Greg Coffey, Uma Sinha, Anjali Pandey, William G. Wierda, Michael J. Keating, and Jan A. Burger. "Spleen Tyrosine Kinase (Syk) Inhibitors Block B Cell Receptor Signaling and Survival In Chronic Lymphocytic Leukemia." Blood 116, no. 21 (November 19, 2010): 3604. http://dx.doi.org/10.1182/blood.v116.21.3604.3604.
Full textPasquet, Jean-Max, Romain Gioia, Claire Drullion, Valerie Lagarde, Cedric Leroy, Serge Roche, Bruno Cardinaud, and Francois-Xavier Mahon. "Tyrosine Kinase Proteins profiling of Nilotinib Resistant Chronic Myelogenous Leukemia Cells Unravels a Tyrosine Kinase-Mediated Bypass." Blood 114, no. 22 (November 20, 2009): 2175. http://dx.doi.org/10.1182/blood.v114.22.2175.2175.
Full textZheng, Tony, Elizabeth R. Lofurno, Sarah Elgamal, Alexander R. Melrose, Jiaqing Pang, Joseph J. Shatzel, Owen J. T. McCarty, and Joseph Aslan. "Tyrosine Kinase Inhibitors (TKIs) Targeting Syk and BTK Signaling Differentially Affect PI3K Signalosome Organization and Platelet Function." Blood 134, Supplement_1 (November 13, 2019): 2074. http://dx.doi.org/10.1182/blood-2019-129066.
Full textHahn, Cynthia K., Kenneth N. Ross, Rose M. Kakoza, Steven A. Carr, Jinyan Du, Shao-En Ong, Todd R. Golub, and Kimberly Stegmaier. "Syk Is a New Target for AML Differentiation." Blood 110, no. 11 (November 16, 2007): 209. http://dx.doi.org/10.1182/blood.v110.11.209.209.
Full textLin, Yipeng. "Kinase inhibitor therapies for Chronic lymphocytic leukaemia (CLL): SYK, BTK and PI3K inhibitors." Highlights in Science, Engineering and Technology 19 (November 17, 2022): 30–35. http://dx.doi.org/10.54097/hset.v19i.2691.
Full textYAMAOKA, Kunihiro, Kazuyoshi SAITO, and Yoshiya TANAKA. "4. Drugs Targeting Intracellular Molecule: JAK Inhibitor and Syk Inhibitor." Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 44, no. 1 (2013): 23–27. http://dx.doi.org/10.3999/jscpt.44.23.
Full textPerrella, Gina, Samantha J. Montague, Helena C. Brown, Lourdes Garcia Quintanilla, Alexandre Slater, David Stegner, Mark Thomas, Johan W. M. Heemskerk, and Steve P. Watson. "Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear." International Journal of Molecular Sciences 23, no. 1 (January 1, 2022): 493. http://dx.doi.org/10.3390/ijms23010493.
Full textRezaul, Karim, Shigeru Yanagi, Kiyonao Sada, Takanobu Taniguchi, and Hirohei Yamamura. "Protein-tyrosine Kinase p72 syk Is Activated by Platelet Activating Factor in Platelets." Thrombosis and Haemostasis 72, no. 06 (1994): 937–41. http://dx.doi.org/10.1055/s-0038-1648987.
Full textBalaian, Larissa, and Edward D. Ball. "The Anti-Proliferative Effect of Immunotoxin Gemtuzimab Ozogamycin (GO) (Mylotarg) to Acute Myeloid Leukemia (AML) Cells Is Associated with the Level of Protein Kinase Syk Exspression." Blood 104, no. 11 (November 16, 2004): 96. http://dx.doi.org/10.1182/blood.v104.11.96.96.
Full textBuchner, Maike, Constance Baer, Gabriele Prinz, Christine Dierks, Meike Burger, Thorsten Zenz, Stephan Stilgenbauer, Hassan Jumaa, Hendrik Veelken, and Katja Zirlik. "Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia." Blood 115, no. 22 (June 3, 2010): 4497–506. http://dx.doi.org/10.1182/blood-2009-07-233692.
Full textGaino, Stefania, Valeria Zuliani, Rosa Tommasoli, Donatella Benati, Riccardo Ortolani, Carlo Zancanaro, Giorgio Berton, Clara Santonastaso, and Pietro Minuz. "Functional Role of p38 Mitogen Activated Protein Kinase in Platelet Activation induced by a Thromboxane A2 Analogue and by 8-iso-prostaglandin F2 α." Thrombosis and Haemostasis 87, no. 05 (2002): 888–98. http://dx.doi.org/10.1055/s-0037-1613101.
Full textFernandez, Rosemarie, and Suzanne J. Suchard. "Syk Activation Is Required for Spreading and H2O2 Release in Adherent Human Neutrophils." Journal of Immunology 160, no. 10 (May 15, 1998): 5154–62. http://dx.doi.org/10.4049/jimmunol.160.10.5154.
Full textLaw, Debbie A., Lisa Nannizzi-Alaimo, Kathleen Ministri, Paul E. Hughes, Jane Forsyth, Martin Turner, Sanford J. Shattil, Mark H. Ginsberg, Victor L. J. Tybulewicz, and David R. Phillips. "Genetic and Pharmacological Analyses of Syk Function in IIbβ3 Signaling in Platelets." Blood 93, no. 8 (April 15, 1999): 2645–52. http://dx.doi.org/10.1182/blood.v93.8.2645.
Full textLaw, Debbie A., Lisa Nannizzi-Alaimo, Kathleen Ministri, Paul E. Hughes, Jane Forsyth, Martin Turner, Sanford J. Shattil, Mark H. Ginsberg, Victor L. J. Tybulewicz, and David R. Phillips. "Genetic and Pharmacological Analyses of Syk Function in IIbβ3 Signaling in Platelets." Blood 93, no. 8 (April 15, 1999): 2645–52. http://dx.doi.org/10.1182/blood.v93.8.2645.408k13_2645_2652.
Full textMullard, Asher. "FDA approves first-in-class SYK inhibitor." Nature Reviews Drug Discovery 17, no. 6 (June 2018): 385. http://dx.doi.org/10.1038/nrd.2018.96.
Full textPatou, Joke, Gabriele Holtappels, Karen Affleck, Paul van Cauwenberge, and Claus Bachert. "Syk-kinase inhibition prevents mast cell activation in nasal polyps." Rhinology journal 49, no. 1 (March 1, 2011): 100–106. http://dx.doi.org/10.4193/rhino09.147.
Full textCheng, Shuhua, Greg Coffey, X. Hannah Zhang, Rita Shaknovich, Zibo Song, Pin Lu, Anjali Pandey, Ari M. Melnick, Uma Sinha, and Y. Lynn Wang. "SYK inhibition and response prediction in diffuse large B-cell lymphoma." Blood 118, no. 24 (December 8, 2011): 6342–52. http://dx.doi.org/10.1182/blood-2011-02-333773.
Full textKinouchi, Chieko, Kazuya Taguchi, Susumu Shimoyama, Tadaaki Ioroi, Hayato Ogura, Mari Yamamoto, Akiko Iino, et al. "FF-10102-01: A Novel, Highly Selective Spleen Tyrosine Kinase Inhibitor, to Be in Clinical Application for Treatment of Autoimmune Diseases and B-Cell Malignancies." Blood 128, no. 22 (December 2, 2016): 3745. http://dx.doi.org/10.1182/blood.v128.22.3745.3745.
Full textYang, Won Seok, Joon-Seok Kim, Nam Jeong Han, Mee Jeong Lee, and Su-Kil Park. "Toll-Like Receptor 4/Spleen Tyrosine Kinase Complex in High Glucose Signal Transduction of Proximal Tubular Epithelial Cells." Cellular Physiology and Biochemistry 35, no. 6 (2015): 2309–19. http://dx.doi.org/10.1159/000374034.
Full textKuroda, Etsushi, Keiichi Ohata, Cevayir Coban, and Ken Ishii. "Particulates induce macrophages to produce lipid mediators via the Syk activation. (172.25)." Journal of Immunology 188, no. 1_Supplement (May 1, 2012): 172.25. http://dx.doi.org/10.4049/jimmunol.188.supp.172.25.
Full textHartman, Amy D., Annique Wilson-Weekes, Theresa Ruffin, Katie J. Hincher, Larry D. Cripe, and H. Scott Boswell. "Mechanistic Paradigm for Combination Signal Transduction Inhibitor Therapy in Zap70+ CLL Involves Bicompartmental Functions of EZH2." Blood 110, no. 11 (November 16, 2007): 3099. http://dx.doi.org/10.1182/blood.v110.11.3099.3099.
Full textKörber, Ruth-Miriam, Stefanie AE Held, Solveig Daecke, Marie von Lilienfeld-Toal, Anita Bringmann, and Peter Brossart. "Targeting Syk (spleen tyrosine kinase) Inhibits the Proliferation, Migration and Viability of Multiple Myeloma Cells." Blood 116, no. 21 (November 19, 2010): 4071. http://dx.doi.org/10.1182/blood.v116.21.4071.4071.
Full textFlynn, Ryan, Jessica L. Allen, Leo Luznik, Kelli P. MacDonald, Katelyn Paz, Kylie A. Alexander, Ante Vulic, et al. "Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease." Blood 125, no. 26 (June 25, 2015): 4085–94. http://dx.doi.org/10.1182/blood-2014-08-595470.
Full textSpurgeon, Stephen, Luke B. Fletcher, Jeffrey W. Tyner, Brian J. Druker, Anjali Pandey, Uma Sinha, and Marc M. Loriaux. "P505-15, a Highly Selective SYK Inhibitor, Shows Significant Activity In Primary CLL Cells and Is Synergistic with Fludarabine at Low Concentrations." Blood 116, no. 21 (November 19, 2010): 2839. http://dx.doi.org/10.1182/blood.v116.21.2839.2839.
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