Academic literature on the topic 'Syk Inhibitor'
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Journal articles on the topic "Syk Inhibitor"
Zhao, Xiaoxian, Andrew E. Schade, and Eric Hsi. "Distinct Role of Src Family Kinase Inhibitors in Burkitt Lymphoma Cells Vs. Diffuse Large B-Cell Lymphoma Cells." Blood 112, no. 11 (November 16, 2008): 3765. http://dx.doi.org/10.1182/blood.v112.11.3765.3765.
Full textMakhoul, Stephanie, Stephanie Dorschel, Stepan Gambaryan, Ulrich Walter, and Kerstin Jurk. "Feedback Regulation of Syk by Protein Kinase C in Human Platelets." International Journal of Molecular Sciences 21, no. 1 (December 25, 2019): 176. http://dx.doi.org/10.3390/ijms21010176.
Full textCoates, Matthew S., Eric W. F. W. Alton, Garth W. Rapeport, Jane C. Davies, and Kazuhiro Ito. "Pseudomonas aeruginosa induces p38MAP kinase-dependent IL-6 and CXCL8 release from bronchial epithelial cells via a Syk kinase pathway." PLOS ONE 16, no. 2 (February 1, 2021): e0246050. http://dx.doi.org/10.1371/journal.pone.0246050.
Full textWang, Xing, Junfang Guo, Zhongqi Ning, and Xia Wu. "Discovery of a Natural Syk Inhibitor from Chinese Medicine through a Docking-Based Virtual Screening and Biological Assay Study." Molecules 23, no. 12 (November 28, 2018): 3114. http://dx.doi.org/10.3390/molecules23123114.
Full textBertoni, Francesco, Andrea Rinaldi, Anna Sasso, Gianluca Gaidano, Emanuele Zucca, Silvia Uccella, Giancarlo Pruneri, et al. "In Vitro Activity of SYK and BCR-ABL Inhibitors in Aggressive Lymphomas." Blood 108, no. 11 (November 16, 2006): 2520. http://dx.doi.org/10.1182/blood.v108.11.2520.2520.
Full textBuchner, Maike, Simon Fuchs, Gabriele Prinz, Dietmar Pfeifer, Kilian Bartholomé, Nina Chevalier, Laurent Vallat, et al. "Spleen Tyrosine Kinase (SYK) Is Overexpressed and Represents a Potential Therapeutic Target in Chronic Lymphocytic Leukemia." Blood 112, no. 11 (November 16, 2008): 543. http://dx.doi.org/10.1182/blood.v112.11.543.543.
Full textYang, Na, Wei Deng, Qiaoling Sun, Junqing Liang, Linfang Wang, Shiming Fan, Renxiang Tang, et al. "HMPL-523, a Novel SYK Inhibitor Showed Anti-Tumor Activities In Vitro and In Vivo." Blood 128, no. 22 (December 2, 2016): 3970. http://dx.doi.org/10.1182/blood.v128.22.3970.3970.
Full textHuang, Duen-Yi, Wei-Yu Chen, Chi-Long Chen, Nan-Lin Wu, and Wan-Wan Lin. "Synergistic Anti-Tumour Effect of Syk Inhibitor and Olaparib in Squamous Cell Carcinoma: Roles of Syk in EGFR Signalling and PARP1 Activation." Cancers 12, no. 2 (February 19, 2020): 489. http://dx.doi.org/10.3390/cancers12020489.
Full textGetz, Todd M., Bhanu Manne, Lorena Buitrago, Yingying Mao, and Satya P. Kunapuli. "Dextran sulphate induces fibrinogen receptor activation through a novel Syk-independent PI-3 kinase-mediated tyrosine kinase pathway in platelets." Thrombosis and Haemostasis 109, no. 06 (2013): 1131–40. http://dx.doi.org/10.1160/th12-09-0645.
Full textIssara-Amphorn, Jiraphorn, Naraporn Somboonna, Prapaporn Pisitkun, Nattiya Hirankarn, and Asada Leelahavanichkul. "Syk inhibitor attenuates inflammation in lupus mice from FcgRIIb deficiency but not in pristane induction: the influence of lupus pathogenesis on the therapeutic effect." Lupus 29, no. 10 (July 22, 2020): 1248–62. http://dx.doi.org/10.1177/0961203320941106.
Full textDissertations / Theses on the topic "Syk Inhibitor"
Yamamoto, Noriyuki. "Development of a selective inhibitor for Syk tyrosine kinase and investigation of its pharmacological activities." 京都大学 (Kyoto University), 2003. http://hdl.handle.net/2433/148369.
Full textRoders, Nathalie. "Régulation de l'activation de lymphocytes B / cellules plasmatiques pendant le rejet chronique : Le rôle de SYK dans la modulation de Mcl-1." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS439/document.
Full textRenal failure is a major public health concern and renal transplantation is the main therapeutic option, however it comes with the risk of organ rejection. B-cells play an important role in antibody-mediated rejection (AMR). During chronic AMR, tertiary lymphoid germinal center (GC)-like structures appear in the rejected organ, associated with de novo production of donor-specific plasma and memory B-cells. Which are B-cell populations that are often poorly controlled by current treatments. Myeloid cell leukemia-1 (Mcl-1), an anti-apoptotic member of the B-cell lymphoma-2 (Bcl-2) family, is essential for maintaining the GC reaction and B-cell differentiation. We report here the infiltration of B-cells expressing Mcl-1 in the kidney of patients with chronic AMR, as observed for (pre-)GC cells. The impairment of B-cell receptor (BCR) signaling, by inhibition of spleen tyrosine kinase (SYK), reduced viability and Mcl-1 protein levels in GC like cells. This downregulation is coordinated at the transcriptional level, potentially via signal transducer and activator of transcription 3 (STAT3), as shown by (1) impaired translocation of STAT3 to the nucleus following SYK inhibition, and (2) the lower levels of Mcl-1 transcription upon STAT3 inhibition. Moreover, overexpression of Mcl-1 prevented cells from entering apoptosis after SYK inhibition. In vitro studies with primary tonsillar B-cells confirmed that SYK inhibition decreased cell survival. We also found that SYK inhibition decreased Mcl-1 protein levels in primary B-cells, and that B-cell activation was inhibited, as determined by CD80 expression and lower levels of IgG secretion in tonsillar B-cells activated in vitro. Overall, our data suggest that the SYK-Mcl-1 pathway may provide new opportunities for the treatment and prevention of AMR
Abadleh, Mohammed Mustafa Mohammed. "Diarylisoxazole als Leitstruktur für Design und Synthese von Proteinkinase Inhibitoren = Diarylisoxazoles as lead for the design and synthesis of protein kinase inhibitors /." Tübingen, 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000276718.
Full textXu, Mingming. "Discovery of inhibitors against a-synuclein aggregation." Thesis, Griffith University, 2020. http://hdl.handle.net/10072/392373.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Environment and Sc
Science, Environment, Engineering and Technology
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Coombes, Susan. "Boards of directors and nonprofit entrepreneurial orientation Catalyst, inhibitor, or inconsequential /." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2008. http://wwwlib.umi.com/cr/syr/main.
Full textBracht, Kathrin. "Neue Inhibitoren zellmembranständiger Proteinkinasen /." Konstanz, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000252796.
Full textCohen, Jason C. "Attention mechanisms and inhibition of return in the somatosensory system." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2002. http://wwwlib.umi.com/cr/syr/main.
Full textAmanovic, Ilijana. "Ginkgo biloba extract inhibits tissue factor degradation /." [S.l.] : [s.n.], 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000278514.
Full textWollmann, Heike. "MiRNA targeting mechanisms - translation inhibition versus transcript cleavage /." Tübingen, 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000251923.
Full textBühler, Nico Martin. "Selektive COX-2 Inhibitoren und Nierenschädigung bei salzsensitiver Hypertonie /." [S.l.] : [s.n.], 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000297941.
Full textBooks on the topic "Syk Inhibitor"
Remer, Imke Ilina. Syk-Inhibition mit Fostamatinib reduziert die Makrophagenakkumulation in atherosklerotischen Plaques. [S.l: s.n.], 2014.
Find full textFleischmann, Roy. Signalling pathway inhibitors. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0081.
Full textBook chapters on the topic "Syk Inhibitor"
Ishida, Yoji. "Others (Syk Inhibitor and Other Medications)." In Autoimmune Thrombocytopenia, 183–89. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4142-6_18.
Full textDenyer, Jane, and Vipul Patel. "Syk kinase inhibitors." In New Drugs and Targets for Asthma and COPD, 283–88. Basel: KARGER, 2010. http://dx.doi.org/10.1159/000320832.
Full textFleischmann, Roy. "Signalling pathway inhibitors." In Oxford Textbook of Rheumatology, 630–35. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0081_update_003.
Full textSingh, Rajinder, and Esteban S. Masuda. "Chapter 24 Spleen Tyrosine Kinase (Syk) Biology, Inhibitors and Therapeutic Applications." In Annual Reports in Medicinal Chemistry Volume 42, 379–91. Elsevier, 2007. http://dx.doi.org/10.1016/s0065-7743(07)42024-3.
Full textKumar Chatterjee, Swapan, Snigdha Saha, and Shahin Muhammed T.K. "COVID-19 and Its Impact on Onset and Progression of Parkinson’s and Cognitive Dysfunction." In COVID-19 Pandemic, Mental Health and Neuroscience - New Scenarios for Understanding and Treatment [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.105667.
Full textConference papers on the topic "Syk Inhibitor"
Lamb, David, Katherina Sewald, Ewald Benediktus, and Armin Braun. "Evaluating a CD63 assay as a biomarker for SYK inhibitor activity." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.3301.
Full textReddy, Sanjeeva, Nitin K. Damle, Aranapakam M. Venkatesan, Scott K. Thompson, Niranajan Rao, Roger A. Smith, and Sandeep Gupta. "Abstract 792: ASN002: A novel dual SYK/JAK inhibitor with strong antitumor activity." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-792.
Full textChow, Chung-Wai, Patricia Castellanos Penton, Michelle North, Hajera Amatullah, Xiaomin Wang, and Jeremy Scott. "Treatment With Syk Inhibitor Attenuates Airway Hyperresponsiveness In A Chronic Murine Model Of Asthma." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2846.
Full textJoshi, Shweta, Kevin Liu, Muamera Zulcic, Alok Singh, Timothy Pham, Christopher K. Glass, Andrew Sharabi, Guillermo A. Morales, Joseph R. Garlich, and Donald Durden. "Abstract 109: Myeloid Syk-PI3Kg-HIF axis inhibits anti-tumor adaptive immunity:In silicodesign of a “first in class” novel dual-Syk/PI3K inhibitor, SRX3207, to block the immunosuppressive tumor microenvironment." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-109.
Full textJoshi, Shweta, Kevin Liu, Muamera Zulcic, Alok Singh, Timothy Pham, Christopher K. Glass, Andrew Sharabi, Guillermo A. Morales, Joseph R. Garlich, and Donald Durden. "Abstract 109: Myeloid Syk-PI3Kg-HIF axis inhibits anti-tumor adaptive immunity:In silicodesign of a “first in class” novel dual-Syk/PI3K inhibitor, SRX3207, to block the immunosuppressive tumor microenvironment." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-109.
Full textSappal, Jessica J., Matthew Theisen, Zhongmin Xiang, Stephen Tirrell, Rudy Christmas, Jie Yu, Mengkun Zhang, and Karuppiah Kannan. "Abstract 3844: TAK-659, a SYK kinase inhibitor, demonstrates preclinical antitumor activity in solid tumor models." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-3844.
Full textKim, Seon Uk, Hyun Jung Yoo, Shin Eui Kang, Ji Soo Park, Ra Ham Kim, Jin Kyun Park, Eun Young Lee, and Yeong Wook Song. "AB0126 ANTI-INFLAMMATORY EFFECTS OF SPLEEN TYROSINE KINASE (SYK) INHIBITOR, PICEATANNOL, ON FIBROBLAST-LIKE SYNOVIOCYTE IN RHEUMATOID ARTHRITIS." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.6696.
Full textTannheimer, Stacey L., Adam Kashishian, Rick Sorensen, and Kathleen S. Keegan. "Abstract 2371: Entospletinib, a potent SYK inhibitor, blocks constitutive and FCgRI activated signaling in FLT3-ITD cell lines." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-2371.
Full textAllan, Richard, Ieuan Jones, Michael Bartley, Darren Wilbraham, and Dave Singh. "A Randomised, Placebo Controlled Trial Of The Effect Of An Inhaled Syk Inhibitor On Allergen Induced Airways Responses In Mild Asthma." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2774.
Full textReddy, Sanjeeva P., Niranjan Rao, David Zammit, Scott K. Thompson, Roger A. Smith, and Louis Denis. "Abstract 4204: ASN002: A novel dual SYK/JAK inhibitor with strong antitumor activity in both hematological and solid tumor xenograft models." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-4204.
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