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Journal articles on the topic 'Suture applications'

Author: Grafiati
Published: 29 June 2021
Last updated: 7 February 2022

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1

Guambo, María Paula Romero, Lilian Spencer, Nelson Santiago Vispo, Karla Vizuete, Alexis Debut, Daniel C. Whitehead, Ralph Santos-Oliveira, and Frank Alexis. "Natural Cellulose Fibers for Surgical Suture Applications." Polymers 12, no. 12 (December 18, 2020): 3042. http://dx.doi.org/10.3390/polym12123042.

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Suture biomaterials are critical in wound repair by providing support to the healing of different tissues including vascular surgery, hemostasis, and plastic surgery. Important properties of a suture material include physical properties, handling characteristics, and biological response for successful performance. However, bacteria can bind to sutures and become a source of infection. For this reason, there is a need for new biomaterials for suture with antifouling properties. Here we report two types of cellulose fibers from coconut (Cocos nucifera) and sisal (Agave sisalana), which were purified with a chemical method, characterized, and tested in vitro and in vivo. According to SEM images, the cellulose fiber from coconut has a porous surface, and sisal has a uniform structure without internal spaces. It was found that the cellulose fiber from sisal has mechanical properties closer to silk fiber biomaterial using Ultimate Tensile Strength. When evaluating the cellulose fibers biodegradability, the cellulose from coconut showed a rapid weight loss compared to sisal. The antifouling test was negative, which demonstrated that neither possesses intrinsic microbicidal activity. Yet, a weak biofilm was formed on sisal cellulose fibers suggesting it possesses antifouling properties compared to cellulose from coconut. In vivo experiments using healthy mice demonstrated that the scarring and mechanical connection was like silk for both cellulose fibers. Overall, our results showed the potential use of cellulose fibers from vegetal for surgical sutures due to excellent mechanical properties, rapid degradation, and no bacterial adhesion.
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Liu, Shuqiang, Gaihong Wu, Xiaogang Chen, Xiaofang Zhang, Juanjuan Yu, Mingfang Liu, Yao Zhang, and Peng Wang. "Degradation Behavior In Vitro of Carbon Nanotubes (CNTs)/Poly(lactic acid) (PLA) Composite Suture." Polymers 11, no. 6 (June 8, 2019): 1015. http://dx.doi.org/10.3390/polym11061015.

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Poly(lactic acid) (PLA) suture can be absorbed by the human body, and so have wide applications in modern surgery operations. The degradation period of PLA suture is expected to meet with the healing time of different types of wounds. In order to control the degradation period of the PLA suture, the carbon nanotubes (CNTs) were composited with PLA suture, and the degradation experiment in vitro was performed on sutures. The structure and properties of sutures during degradation, such as surface morphology, breaking strength, elongation, mass and chemical structure, were tracked and analyzed. The results indicated that the degradation brought about surface defects and resulted in 13.5 weeks for the strength valid time of the original PLA suture. By contrast, the strength valid time of the CNTs/PLA suture was increased to 26.6 weeks. Whilst the toughness of both the pure PLA and CNTs/PLA sutures decreased rapidly and almost disappeared after 3 to 4 weeks of degradation. The mass loss demonstrated that the time required for complete degradation of the two sutures was obviously different, the pure PLA suture 49 weeks, while CNTs/PLA sutures 63 to 73 weeks. The research proved that CNTs delayed PLA degradation and prolonged its strength valid time in degradation.
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3

Azhahia Manavalan, R., and A. Mukhopadhyay. "Surgical Sutures: Performance, Development and Use." Journal of Biomimetics, Biomaterials and Tissue Engineering 1 (July 2008): 1–36. http://dx.doi.org/10.4028/www.scientific.net/jbbte.1.1.

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The paper reports about different kind of sutures, their suitability and performance. An ideal suture should possess many characteristics such as - easy to handle, bio-compatibility, minimal tissue reaction, resistance to bacterial growth, adequate tensile strength and elasticity, knot security, strength loss versus healing rate of tissues. Selection of suture is often very complex for satisfying host of physical, mechanical and biological properties, and fulfilling contradictory requirements in varied applications. The paper develops an understanding about the selection of suture depending on the varied requirement. Past research work pertaining to the development of suture as reported in this paper, provides insight about the suitability of different surgical sutures and possible direction of future research.
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4

Antoniac, Iulian, Aurora Antoniac, Daniela Gheorghita, and Sebastian Gradinaru. "In Vitro Study on Biodegradation of Absorbable Suture Materials Used for Surgical Applications." Materiale Plastice 58, no. 2 (July 5, 2021): 130–39. http://dx.doi.org/10.37358/mp.21.2.5484.

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Abstract: The presented experimental research aims to compare the degradation degree of five different types of surgical sutures used in clinical practice and to discuss the influence of local pH on the degradation of a suture material. The surgical sutures were tested in terms of stability and hydrolytic biodegradation in Phosphate Buffer Saline (PBS) solution varying the pH and the immersion time of the samples in the liquid medium. The surface properties, structural characteristics and the effects of hydrolytic biodegradation on the mechanical properties were studied using Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), Degradation degree and Tensile Strength tests, respectively.
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5

Punyanitya, Sittiporn, Rungsarit Koonawoot, Sakdiphon Thiensem, Surasit Laosatirawong, and Anirut Raksujarit. "Absorbable Suture Made from Rice Starch." Advanced Materials Research 123-125 (August 2010): 291–94. http://dx.doi.org/10.4028/www.scientific.net/amr.123-125.291.

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The main objective of this work is to make an absorbable monofilament suture from Thai rice starch. The improvement of the mechanical properties of Thai rice starch polymer films were achieved by addition of small amount of gelatin, carboxymethylcellulose (CMC) and carbon nanopowders. The carbon nanopowders were produced from coconut shell in our laboratory room by milling method. The incorporation of carbon nanopowders with a high aspect ratio and/or an extremely large surface area into Thai rice starch polymer films improves their mechanical performances significantly. Additionally, the black color from carbon nanopowder is easily visualized in tissue during surgery. The manufacturing processes are very simple by blending of the raw materials in hot water and then dry heating in electric oven. The final product was characterized of microstructures and mechanical properties. The resulting Thai rice starch-carbon nanocomposites possess several advantages for manufacture of sutures: 1. high water resistance that can be uses in the human body. 2. high mechanical strength that appropriate to manufacture of sutures. 3. biocompatibility and bioabsorbable. 4. low cost. 5. Eco-friendly green nanocomposites. However, the method of size designation of sutures fibers and needle attachment are the problem which restricts our suture in really applications. The investigation of knowledge and simple technology of manufacture of suture and needle attachment will be performed.
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6

Tiftikci, Uğur, and Sancar Serbest. "The Optimal Placement of Sutures in All-inside Repair of Meniscocapsular Separation." Open Orthopaedics Journal 10, no. 1 (April 8, 2016): 89–93. http://dx.doi.org/10.2174/1874325001610010089.

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Background:The aim of this study was to show the effects on the meniscus of repair applied from the femoral, the femoral-tibial and the tibial surfaces.Methods:In the treatment of meniscocapsular separation, although the accepted gold standard technique in the past was the inside-out suture technique, the current treatment method is all-inside repair methods. The all-inside techniques include the hook method and applications with a meniscus suture device. The hook method is difficult with a steep learning curve. In meniscus repair applied with the all-inside meniscus devices, the application of the suture can change the anatomic structure and position of the meniscus.Results:The suturing method applied from the tibial section of the meniscus does not disrupt the anatomic position of the meniscus in meniscocapsular separation. Thus, the optimum conditions are provided for restoration of the functions of the meniscus.Conclusion:The optimal repair in meniscocapsular separations can be considered to be that made with sutures from the tibial section of the meniscus. This technique may be helpful in obtaining better clinical results.
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7

Odermatt, Erich K., Lutz Funk, Rainer Bargon, David P. Martin, Said Rizk, and Simon F. Williams. "MonoMax Suture: A New Long-Term Absorbable Monofilament Suture Made from Poly-4-Hydroxybutyrate." International Journal of Polymer Science 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/216137.

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A long-term absorbable monofilament suture was developed using poly-4-hydroxybutyrate (P4HB) made from a biosynthetically produced homopolymer of the natural metabolite 4-hydroxybutyrate. The suture, called MonoMax, has prolonged strength retention. At 12 weeks, a size 3-0 MonoMax suture retains approximately 50% of its initial tensile strengthin vivoand is substantially degraded in one year with minimal tissue reaction. In contrast, PDS II monofilament suture (Ethicon, Inc., Somerville, NJ) has no residual strengthin vivoafter 12 weeks.In vivo, the MonoMax suture is hydrolyzed primarily by bulk hydrolysis, and is then degraded via the Krebs cycle. MonoMax is substantially more compliant than other monofilament sutures, and incorporates an element of elasticity. Its tensile modulus of 0.48 GPa is approximately one-third of the value of the PDS II fiber providing an exceptionally flexible and pliable fiber with excellent knot strength and security. These features are further enhanced by the fiber's elasticity, which also improves knot security and may help prevent wound dehiscence. Because of its performance advantages, this suture may find clinical utility in applications where prolonged strength retention, and greater flexibility are required, particularly in procedures like abdominal wall closure where wound dehiscence is still a significant post-surgical complication.
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8

Biswas, Arpan, Akhand Pratap Singh, Dipak Rana, Vinod K. Aswal, and Pralay Maiti. "Biodegradable toughened nanohybrid shape memory polymer for smart biomedical applications." Nanoscale 10, no. 21 (2018): 9917–34. http://dx.doi.org/10.1039/c8nr01438h.

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Templated polyurethane is designed which shows superior shape memory behavior at ambient condition suitable for suture and stent application. Biodegradable and toughened nature add extra features of this hybrid material for versatile applications.
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9

Cummings, John F. "A Miniature Suture Tensiometer for Laparoscopic Applications." Journal of Investigative Surgery 13, no. 5 (January 2000): 253–58. http://dx.doi.org/10.1080/08941930050206265.

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10

Golz, Andrew, Jonathan Yun, Nickolas Garbis, and Dane Salazar. "The effect of pulsed lavage irrigation on suture knot security." Journal of Orthopaedic Surgery 28, no. 1 (January 1, 2020): 230949901988812. http://dx.doi.org/10.1177/2309499019888129.

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Purpose: The purpose of this study was to determine the effect of low-pressure and pulsed lavage irrigation on suture knot security. Methods: Ninety-tied suture loops were measured for baseline circumference and then subjected to no irrigation, bulb syringe irrigation, or pulsed lavage irrigation. The sutures were placed under a load and then measured for final circumference. A larger circumference difference indicated poorer knot security. Results: There was a statistically significant difference in the knot security between all three groups ( p < 0.001). Pulsed lavage resulted in the greatest circumference increase (0.52 ± 0.19 mm), followed by bulb syringe (0.24 ± 0.18 mm), and lastly no irrigation (0.08 ± 0.00 mm). None of the groups had any catastrophic failures. No knots met the predetermined criteria for knot failure. Conclusion: Pulsed lavage irrigation resulted in a statistically significant decrease in suture knot security as compared to bulb syringe irrigation and no irrigation. None of the groups met the currently accepted criteria for clinical suture failure, which has a relatively arbitrary value. While the available literature does not discuss increases in loop circumference for specific orthopedic applications, this small difference suggests that pulse lavage is unlikely to have a clinically significant impact on the suture integrity for most orthopedic procedures.
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11

Rojo, Ana, Laura Raya, and Alberto Sanchez. "A Novel Mixed Reality Solution Based on Learning Environment for Sutures in Minor Surgery." Applied Sciences 11, no. 5 (March 6, 2021): 2335. http://dx.doi.org/10.3390/app11052335.

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Minor Surgery Sutures is a fundamental skill for healthcare professionals. However, in the educational field, the practice of suturing is sometimes limited and reduced, with more theoretical than practical study. In order to facilitate learning, our goal is to develop an immersive and interactive educational tool that complements theoretical study, called Suture MR. This application could enhance suture procedural skills in the fields of nursing and medicine. Applying Mixed Reality techniques, we generate a 3D model of an arm with a full-scale wound. Realistically, the user will simulate the suture movements as part of the learning process. The application has surgical clamps and a needle holder that are virtually visualized in the user’s hands, allowing gestures and movements faithful to the real ones. In this article, we want to demonstrate the usability of our environment and the feasibility of using Mixed Reality learning experiences in clinical practical training as a complement to theoretical training. The results of the study reveal a greater perception of learning and the willingness of students to use this methodology.
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12

Khalil, Islam A., Bahram Saleh, Dina M. Ibrahim, Clotilde Jumelle, Ann Yung, Reza Dana, and Nasim Annabi. "Ciprofloxacin-loaded bioadhesive hydrogels for ocular applications." Biomaterials Science 8, no. 18 (2020): 5196–209. http://dx.doi.org/10.1039/d0bm00935k.

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13

Ghafoor, Bakhtawar, Murtaza Najabat Ali, Umar Ansari, Muhammad Faraz Bhatti, Mariam Mir, Hafsah Akhtar, and Fatima Darakhshan. "New Biofunctional Loading of Natural Antimicrobial Agent in Biodegradable Polymeric Films for Biomedical Applications." International Journal of Biomaterials 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/6964938.

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The study focuses on the development of novelAloe verabased polymeric composite films and antimicrobial suture coatings. Polyvinyl alcohol (PVA), a synthetic biocompatible and biodegradable polymer, was combined withAloe vera, a natural herb used for soothing burning effects and cosmetic purposes. The properties of these two materials were combined together to get additional benefits such as wound healing and prevention of surgical site infections. PVA andAloe verawere mixed in a fixed quantity to produce polymer based films. The films were screened for antibacterial and antifungal activity against bacterial (E. coli,P. aeruginosa) and fungal strains (Aspergillus flavusandAspergillus tubingensis) screened.Aloe verabased PVA films showed antimicrobial activity against all the strains; the lowestAloe veraconcentration (5%) showed the highest activity against all the strains.In vitrodegradation and release profile of these films was also evaluated. The coating for sutures was prepared,in vitroantibacterial tests of these coated sutures were carried out, and later onin vivostudies of these coated sutures were also performed. The results showed that sutures coated withAloe vera/PVA coating solution have antibacterial effects and thus have the potential to be used in the prevention of surgical site infections andAloe vera/PVA based films have the potential to be used for wound healing purposes.
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14

Gould, Heath P., William R. Rate, Pooyan Abbasi, Katherine L. Mistretta, and Jason W. Hammond. "Adjustable Cortical Fixation Device for Quadriceps Tendon Repair: A Cadaveric Biomechanical Study." Orthopaedic Journal of Sports Medicine 9, no. 1 (January 1, 2021): 232596712097439. http://dx.doi.org/10.1177/2325967120974393.

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Background: Adjustable cortical fixation devices have demonstrated utility in orthopaedic applications, such as ankle syndesmosis repair. Purpose: To assess the cyclic gap formation of a quadriceps tendon repair technique using an adjustable cortical fixation device compared with repair with knotless suture anchors and suture tape, a modification of conventional suture anchor repair. Study Design: Controlled laboratory study. Methods: Eight fresh-frozen matched pairs of cadaveric knees were used. Specimens in each pair were randomized to undergo either modified suture anchor repair (control) or adjustable cortical fixation repair. The control repair was performed as previously described. The experimental repair was performed using 2 No. 2 FiberWire sutures placed into the quadriceps tendon in a running locked Krackow configuration and 2 adjustable loop devices passed through transosseous tunnels. The lagging strands of the devices were tensioned to seat the cortical fixation buttons at the inferior patellar pole and then tied to the free Krackow strands at the superior pole to complete the repair. The mean plastic gap (permanent tendon displacement that did not recover with cyclic extension) and mean maximum gap (peak displacement that occurred with cyclic knee flexion and partially recovered with extension) were evaluated during cyclic loading for 500 cycles of full knee extension to 90° of flexion. Results: At all testing intervals, the mean plastic gap was significantly smaller for the cortical fixation group versus the suture anchor group ( P < .02). Similarly, the mean maximum gap was significantly smaller for the cortical fixation specimens at all testing intervals ( P < .01). After cyclic loading, the mean maximum gap was significantly smaller in the cortical fixation group (4.80 ± 1.56 mm) versus the suture anchor group (8.47 ± 1.47 mm; P = < .001). The mean plastic gap was also significantly smaller in the cortical fixation versus the suture anchor group (3.25 ± 1.10 mm vs 6.57 ± 1.62 mm, respectively; P = < .001). Conclusion: Quadriceps tendon repair using an adjustable cortical fixation device demonstrated superior biomechanical properties in cyclic displacement testing compared with repair using the suture anchor technique. Clinical Relevance: These results suggest that an adjustable cortical fixation device is a biomechanically viable alternative for quadriceps tendon repair.
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McGary, Ryan T., Thomas M. Johnson, Joshua P. Berridge, James P. Wilson, and Dmitry Baron. "The Tissue‐Supported Sling Suture: Technique and Clinical Applications." Clinical Advances in Periodontics 10, no. 3 (November 19, 2019): 107–17. http://dx.doi.org/10.1002/cap.10081.

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Wentzell, Michael J., and Jared Jacob Lund. "The Inverting Horizontal Mattress Suture: Applications in Dermatologic Surgery." Dermatologic Surgery 38, no. 9 (September 2012): 1535–39. http://dx.doi.org/10.1111/j.1524-4725.2012.02484.x.

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17

Mitchell, Ryan T. M., and Bradley P. Bengtson. "Clinical Applications of Barbed Suture in Aesthetic Breast Surgery." Clinics in Plastic Surgery 42, no. 4 (October 2015): 595–604. http://dx.doi.org/10.1016/j.cps.2015.06.003.

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18

Macdonald, CR, and PE Banwell. "Twist-over: stainless steel suture technique for skin graft applications." Annals of The Royal College of Surgeons of England 96, no. 3 (April 2014): 254. http://dx.doi.org/10.1308/003588414x13814021679276.

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19

Zhang, Meng, Ci Li, Li-Ping Zhou, Wei Pi, and Pei-Xun Zhang. "Polymer Scaffolds for Biomedical Applications in Peripheral Nerve Reconstruction." Molecules 26, no. 9 (May 5, 2021): 2712. http://dx.doi.org/10.3390/molecules26092712.

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The nervous system is a significant part of the human body, and peripheral nerve injury caused by trauma can cause various functional disorders. When the broken end defect is large and cannot be repaired by direct suture, small gap sutures of nerve conduits can effectively replace nerve transplantation and avoid the side effect of donor area disorders. There are many choices for nerve conduits, and natural materials and synthetic polymers have their advantages. Among them, the nerve scaffold should meet the requirements of good degradability, biocompatibility, promoting axon growth, supporting axon expansion and regeneration, and higher cell adhesion. Polymer biological scaffolds can change some shortcomings of raw materials by using electrospinning filling technology and surface modification technology to make them more suitable for nerve regeneration. Therefore, polymer scaffolds have a substantial prospect in the field of biomedicine in future. This paper reviews the application of nerve conduits in the field of repairing peripheral nerve injury, and we discuss the latest progress of materials and fabrication techniques of these polymer scaffolds.
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20

Grujicic, M., C. L. Zhao, and E. M. Austin. "Optimization of a piezoelectric bimorph grasper for use in minimally invasive surgical applications." Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture 219, no. 9 (September 1, 2005): 673–83. http://dx.doi.org/10.1243/095440505x32607.

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The potential use of piezoelectric bimorph actuators in minimally invasive surgery suture-needle grasper/holder applications is explored computationally. Upon defining the design/functional requirements for such surgical tools, a finite element analysis of the underlying piezoelectric boundary value problem is combined with the genetic algorithm optimization routine to arrive at an optimal morphology of the suture-needle grasper/holder. The results obtained show that, if the actuator is based on several constant-thickness segments, a proper combination of thicknesses of such segments can substantially improve the performance of such surgical tools. Specifically, a good combination of the relatively large grasper-jaws opening and the required level of the holding force when the grasper is closed on a 0.5 mm diameter suture-needle is obtained. The effect of orientation of the poling direction in the piezoelectric layers on the performance of the bimorph actuator is also examined. It is found that, at the same level of the required grasping force, a change in the poling direction by about 2.3° from the through-the-thickness direction can increase the maximum grasper-jaws opening by about 10 per cent.
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21

Bush, Carrie M., John D. Prosser, Michele P. Morrison, Guri Sandhu, Karl H. Wenger, David H. Pashley, Martin A. Birchall, Gregory N. Postma, and Paul M. Weinberger. "New technology applications: Knotless barbed suture for tracheal resection anastomosis." Laryngoscope 122, no. 5 (March 30, 2012): 1062–66. http://dx.doi.org/10.1002/lary.23229.

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TAN, RHH, RJW BELL, BA DOWLING, and AJ DART. "Suture materials: composition and applications in vetern-ary wound repair." Australian Veterinary Journal 81, no. 3 (March 2003): 140–45. http://dx.doi.org/10.1111/j.1751-0813.2003.tb11075.x.

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23

Shokrollahi, K., and S. Sofos. "Twist-over: stainless steel suture technique for skin graft applications." Annals of The Royal College of Surgeons of England 95, no. 6 (September 2013): 437. http://dx.doi.org/10.1308/rcsann.2013.95.6.437.

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24

Barnhart, M. D., A. J. Kazanovicz, S. J. Naber, and K. C. Maritato. "In vitro mechanical evaluation and comparison of two crimping devices for securing monofilament nylon and multifilament polyethylene for use in extracapsular stabilization of the canine stifle." Veterinary and Comparative Orthopaedics and Traumatology 25, no. 06 (2012): 466–71. http://dx.doi.org/10.3415/vcot-11-10-0141.

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SummaryObjective: To compare the tensile strength and stiffness of non-absorbable suture loops created with two types of crimping devices.Methods: Loops of monofilament nylon leader line (MN) of 18 kg, 36 kg, and 45 kg multifilament polyethylene (MP) with a crimp and MP with a crimp and knot were mechanically tested to failure in quasistatic tensile loading after being created with either a wave pattern crimp device or three applications of a single crimp device. Each testing group consisted of five samples. Tensile loading to failure at a rate of 9.5 mm/s was used. Failure was defined as a sudden drop in the recorded force.Results: All suture materials failed by breaking near the crimp tube with both crimp devices, with exception of the MP without knot, which slipped through the crimp tube using both devices. Sutures secured with the wave pattern crimping device were significantly stronger with a higher load yield, maximum load, displacement yield, failure displacement, and maximum displacement than the single crimp device. Loops of MP suture crimped by either device plus the addition of a surgeon's knot resulted in a significantly stronger construct than unknotted crimped MP constructs. Crimped MP combined with knot were significantly stiffer, but not stronger, than crimped 45 kg MN.Clinical significance: Performing extra- capsular repair for ruptured cranial cruciate ligaments with the wave pattern crimp system may result in lower failure rates due to the construct being significantly stronger than the single crimp system.
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Bassini, R., M. C. Cantone, G. Gambarini, M. Malatesta, N. Molho, and L. Pirola. "Method for measuring suture tension in surgery." Medical & Biological Engineering & Computing 26, no. 4 (July 1988): 451–54. http://dx.doi.org/10.1007/bf02442310.

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Vasanthan, Asvin, Keerthana Satheesh, Wyeth Hoopes, Patrick Lucaci, Karen Williams, and John Rapley. "Comparing Suture Strengths for Clinical Applications: A Novel In Vitro Study." Journal of Periodontology 80, no. 4 (April 2009): 618–24. http://dx.doi.org/10.1902/jop.2009.080490.

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27

He, Chuang-Long, Zheng-Ming Huang, and Xiao-Jian Han. "Fabrication of drug-loaded electrospun aligned fibrous threads for suture applications." Journal of Biomedical Materials Research Part A 89A, no. 1 (April 2009): 80–95. http://dx.doi.org/10.1002/jbm.a.32004.

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28

Palmer, Richard M., and Claude F. Burgoyne. "Applications for a Corneal Mattress Suture in Anterior Limbal Wound Repairs." Ophthalmic Surgery, Lasers and Imaging Retina 25, no. 10 (November 1994): 726–29. http://dx.doi.org/10.3928/1542-8877-19941101-14.

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29

Zhang, Xiaorui, Jiali Duan, Jia Liu, and Norman I. Badler. "An Integrated Suture Simulation System with Deformation Constraint Under A Suture Control Strategy." Computers, Materials & Continua 60, no. 3 (2019): 1055–71. http://dx.doi.org/10.32604/cmc.2019.03915.

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Inyutin, A. S., A. V. Fedoseev, O. V. Krymov, S. Yu Muravyov, and V. I. ogly Rustamov. "Application of combined technique for laparotomy wound closure in urgent surgery." Perm Medical Journal 36, no. 2 (June 23, 2019): 36–43. http://dx.doi.org/10.17816/pmj36236-43.

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Aim. To improve the results of patients’ treatment after midline laparotomy by reducing the number of the postoperative ventral hernias and eventrations. Materials and methods.There were examined 111 urgent patients, operated through the median laparotomic approach. The main group included 48 persons, for whom,on completion of intervention,the white line was sutured with a chess-staggered suture(patent of RF № 2644846, 14.02.18). In the control group, for median aponeurosis interrupted sutures were used. Results. In the early postoperative period, in the control group there were 2 (3 %) eventrations, in the main group – no eventrations. After one year of observations, in the main group – 3 (6 %) patients with aponeurosis defects by the postoperative scar USI and 2 (4 %) patients with hernias were found out. In the control, one year after the surgery, there were 6 (9.5 %) aponeurosis defects and 5 (8 %) postoperative hernias. Conclusions. Application of interrupted chess suture in combination with staggered sutures is the way to prevent eventrations and postoperative ventral hernias in urgent surgery.
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Li, Zheng, Azure Wilson, Lea Sayce, Amit Avhad, Bernard Rousseau, and Haoxiang Luo. "Numerical and Experimental Investigations on Vocal Fold Approximation in Healthy and Simulated Unilateral Vocal Fold Paralysis." Applied Sciences 11, no. 4 (February 18, 2021): 1817. http://dx.doi.org/10.3390/app11041817.

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We have developed a novel surgical/computational model for the investigation of unilat-eral vocal fold paralysis (UVFP) which will be used to inform future in silico approaches to improve surgical outcomes in type I thyroplasty. Healthy phonation (HP) was achieved using cricothyroid suture approximation on both sides of the larynx to generate symmetrical vocal fold closure. Following high-speed videoendoscopy (HSV) capture, sutures on the right side of the larynx were removed, partially releasing tension unilaterally and generating asymmetric vocal fold closure characteristic of UVFP (sUVFP condition). HSV revealed symmetric vibration in HP, while in sUVFP the sutured side demonstrated a higher frequency (10–11%). For the computational model, ex vivo magnetic resonance imaging (MRI) scans were captured at three configurations: non-approximated (NA), HP, and sUVFP. A finite-element method (FEM) model was built, in which cartilage displacements from the MRI images were used to prescribe the adduction, and the vocal fold deformation was simulated before the eigenmode calculation. The results showed that the frequency comparison between the two sides was consistent with observations from HSV. This alignment between the surgical and computational models supports the future application of these methods for the investigation of treatment for UVFP.
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32

SKOFF, H. D., A. T. HECKER, W. C. HAYES, R. SEBELL-SKLAR, and N. STRAUGHN. "Bone Suture Anchors in Hand Surgery." Journal of Hand Surgery 20, no. 2 (April 1995): 245–48. http://dx.doi.org/10.1016/s0266-7681(05)80062-2.

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The recent development of small bone suture anchors has created potential applications in reconstructive surgery of the hand and wrist. A combined laboratory and clinical study was devised to evaluate their use. 16 paired fingers (32 in all) from eight cadaveric hands were disarticulated at the MP joint with a 10 cm tail of FDP tendon. The FDP insertion was released in all specimens. In 16 fingers reinsertion was performed with the classic Bunnell technique; in the paired 16 fingers, the repair utilized Acufex 2 mm anchors. There was no significant difference between the two groups regarding load-to-failure at approximately 40 Newtons. The mean stiffness of the anchor repairs was significantly greater than the Bunnell repairs. 19 consecutive patients were prospectively enrolled with a tendon or ligament repair of the hand or wrist using bone anchors. The average age was 41 years and the average length of follow-up was 24 months. All repairs were stable at the time of follow-up. Bone anchors were simple to insert, required less dissection and surgical time than the Bunnell technique and appeared to be reliable in both laboratory and clinical settings.
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Choi, Jae Hyuk, Donghee Son, and Mikyung Shin. "Sundew-Inspired Adhesive Hydrogel Threads through Reversible Complexation of Polyphenol and Boronic Acid." Applied Sciences 11, no. 18 (September 16, 2021): 8591. http://dx.doi.org/10.3390/app11188591.

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Adhesive hydrogels have been utilized as tissue sealants, hemostatic agents, and wound dressings, with the aim of replacing conventional sutures. To prevent immune response and serious inflammation from those hydrogels after sealing, natural biocompatible polysaccharides are widely used as a component of the hydrogels. However, the weak mechanical strength, insufficient adhesiveness, and rapid dissociation of the hydrogels necessitates additional suturing at the wound site. In this study, we report on a solid polysaccharide thread reversibly crosslinked with boronic acid-polyphenol complexation and its adhesive gelation for complete tissue sealing without additional suturing. The polysaccharide adhesive suture threads demonstrated long-term stability, which is useful when used for skin wound suturing. Specifically, their robust adhesion property occurred as soon as the threads were soaked, attaining a swollen hydrogel state, dependent on the presence of body fluids after suturing. Moreover, the pH of the body fluids affects the viscoelasticity and adhesiveness of the hydrogels in order to ensure a tight sealing. Therefore, we expect that these pH-responsive adhesive threads would be promising for the development of on-demand functional suture materials.
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Ermutlu, Celal Şahin, and Vedat Baran. "Comparison of clinical, biomechanical, and histopathological effects of various suture techniques on repair of tendon rupture by using autograft." Journal of Veterinary Research 61, no. 2 (June 1, 2017): 231–37. http://dx.doi.org/10.1515/jvetres-2017-0030.

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AbstractIntroduction: The purpose of this study was to compare the effectiveness of four different suture techniques in the treatment of experimentally modelled tendon injuries with tissue loss with autograft and grafting applications in rabbits.Material and Methods: The study was performed on 30 male mature (2-year-old) New Zealand rabbits with mean body weight of 3.1 kg, divided into three equal groups. A graft measuring 1 cm in length was collected from the m. tibialis cranialis of each rabbit under general anaesthesia. The graft collected from the right tendon was transplanted into the left tendon, and the graft from the left tendon was transplanted into the right tendon. In all groups, a simple interrupted suture was placed on the left tendon as control, a Bunnell-Mayer suture was placed on the right tendon in group I, a Locking-Loop suture in group II, and a Horizontal U suture in group III. Both hindlimbs were bandaged for four weeks. The tendons were assessed biomechanically and histopathologically.Results: According to the results of the tensile testing, the maximum durability of the techniques ranked as follows: Bunnell-Mayer, Horizontal U, Locking-Loop, and control groups.Conclusion: The use of autografts was a good alternative for the treatment of tendon ruptures with tissue loss. Furthermore, even though there were no clinical or histopathological differences, the suture technique can be chosen based on the results of the tensile test.
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Choi, Woonjae, and Bummo Ahn. "A Flexible Sensor for Suture Training." IEEE Robotics and Automation Letters 4, no. 4 (October 2019): 4539–46. http://dx.doi.org/10.1109/lra.2019.2933995.

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36

Komori, Toshihisa. "Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2." International Journal of Molecular Sciences 20, no. 7 (April 4, 2019): 1694. http://dx.doi.org/10.3390/ijms20071694.

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Runx2 is essential for osteoblast differentiation and chondrocyte maturation. During osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells, and its expression is upregulated in preosteoblasts, reaches the maximal level in immature osteoblasts, and is down-regulated in mature osteoblasts. Runx2 enhances the proliferation of osteoblast progenitors by directly regulating Fgfr2 and Fgfr3. Runx2 enhances the proliferation of suture mesenchymal cells and induces their commitment into osteoblast lineage cells through the direct regulation of hedgehog (Ihh, Gli1, and Ptch1), Fgf (Fgfr2 and Fgfr3), Wnt (Tcf7, Wnt10b, and Wnt1), and Pthlh (Pthr1) signaling pathway genes, and Dlx5. Runx2 heterozygous mutation causes open fontanelle and sutures because more than half of the Runx2 gene dosage is required for the induction of these genes in suture mesenchymal cells. Runx2 regulates the proliferation of osteoblast progenitors and their differentiation into osteoblasts via reciprocal regulation with hedgehog, Fgf, Wnt, and Pthlh signaling molecules, and transcription factors, including Dlx5 and Sp7. Runx2 induces the expression of major bone matrix protein genes, including Col1a1, Spp1, Ibsp, Bglap2, and Fn1, in vitro. However, the functions of Runx2 in differentiated osteoblasts in the expression of these genes in vivo require further investigation.
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Oliveira, Emannuella Araújo de, and Lenilda Austrilino. "Método inovador de ensino para a prática de suturas de pele." Revista Pesquisa Qualitativa 7, no. 14 (July 31, 2019): 282. http://dx.doi.org/10.33361/rpq.2019.v.7.n.14.261.

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Resumo: Este trabalho tem como objetivo mostrar potencialidades de um método inovador de ensino, para prática de sutura de pele, usando materiais orgânicos e sintéticos. Trata-se de um estudo de caso com discentes de medicina, participantes de oficina realizada aplicando técnicas básicas de sutura de pele, com treinamento simulado em três consistências de tecidos. Os dados coletados com questionários e observações avaliando desempenho discente e efetividade do método. As suturas realizadas em EVA, berinjela e língua de boi utilizando ponto simples, simples invertido, Donatti, U horizontal, sutura contínua e intradérmica, compuseram seis estações de avaliação. Após a prática na bancada, os discentes vivenciaram situação real em ambiente ambulatorial. Os discentes foram avaliados com conceitos bom e regular, inclusive na prática ambulatorial, mostra que o método de sutura em consistências diferentes favorece a aprendizagem. A estratégia utilizando material com diversas texturas mostrou-se efetivo para desenvolver habilidades e aquisição de competências para prática de sutura de pele. A oficina despertou interesse para especialidade cirúrgica.Palavras-chave: Educação Médica; Materiais de Ensino; Modelos Educacionais; Cirurgia Técnicas de Sutura; Procedimentos Cirúrgicos Ambulatoriais. Innovative teaching model for the practice of skin suturingAbstract: The objective shows the potentialities of a bench model using organic and synthetic materials, designed to development and skill acquisition in skin suturing. Method: Case study with students of the medical school. A workshop was held to practice skin sutures, providing basic suture techniques with simulated training in three tissue consistencies. Data were collected from the application of questionnaires and observation. After practicing in this bench model, the students had the opportunity to experience real situation in an outpatient setting. Results: On the workbench the sutures were made in the following materials EVA, eggplant and ox tongue, using simple point, simple inverted, Donatti, U horizontal, continuous and intradermal suture. The results show that practice in different consistencies favors learning. Conclusion: The teaching strategy proved effective for the development of skills and acquisition of skills necessary for the practice of skin suture. The workshop aroused interest for the surgical specialty.Keywords: Medical Education; Surgery; Suturing Techniques; Outpatient Surgical; Educational Model.
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Wang, Fu-Jun, Abedalwafa Mohammed, Chao-Jing Li, and Lu Wang. "Promising Poly(ε-caprolactone) Composite Reinforced with Weft-Knitted Polyester for Small-Diameter Vascular Graft Application." Advances in Materials Science and Engineering 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/273891.

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The present study was designed to improve the mechanical performance of a small-diameter vascular prosthesis made from a flexible membrane of poly(ε-caprolactone) (PCL). PCL reinforcement was achieved by embedding a tubular fabric knitted from polyethylene terephthalate (PET) yarns within the freeze-dried composite structure. The knitting density of PET fabric influenced the mechanical properties of the new vascular graft. Results showed that the composite prototype has good mechanical properties, water permeability, elastic recovery, and suture retention strength. Increases in loop density increased compressive strength and suture retention strength and decreased elastic recovery. The new composite prototype vascular graft has promising potential applications in clinics because of its excellent mechanical properties.
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Vesentini, S., A. Redaelli, and F. M. Montevecchi. "Skin nanostructural features determine suture biomechanics." IEEE Transactions on Nanobioscience 2, no. 2 (June 2003): 79–88. http://dx.doi.org/10.1109/tnb.2003.813925.

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40

Salehi, Sahar, Kim Koeck, and Thomas Scheibel. "Spider Silk for Tissue Engineering Applications." Molecules 25, no. 3 (February 8, 2020): 737. http://dx.doi.org/10.3390/molecules25030737.

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Due to its properties, such as biodegradability, low density, excellent biocompatibility and unique mechanics, spider silk has been used as a natural biomaterial for a myriad of applications. First clinical applications of spider silk as suture material go back to the 18th century. Nowadays, since natural production using spiders is limited due to problems with farming spiders, recombinant production of spider silk proteins seems to be the best way to produce material in sufficient quantities. The availability of recombinantly produced spider silk proteins, as well as their good processability has opened the path towards modern biomedical applications. Here, we highlight the research on spider silk-based materials in the field of tissue engineering and summarize various two-dimensional (2D) and three-dimensional (3D) scaffolds made of spider silk. Finally, different applications of spider silk-based materials are reviewed in the field of tissue engineering in vitro and in vivo.
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41

Barbosa, Natália Maria Vieira, Ana Cláudia de Castro, Ferreira Conti, Leopoldino Capelozza-Filho, Renata Rodrigues de Almeida-Pedrin, and Mauricio de Almeida Cardoso. "Reliability and reproducibility of the method of assessment of midpalatal suture maturation: A tomographic study." Angle Orthodontist 89, no. 1 (September 19, 2018): 71–77. http://dx.doi.org/10.2319/121317-859.1.

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ABSTRACT Objectives: To assess reliability and reproducibility of the individual assessment of midpalatal suture maturation in computed tomography among orthodontists and radiologists for potential diagnosis application. Materials and Methods: Sixty axial slices from cone-beam computed tomography and multi-slice CT scans of patients aged between 11 and 21 years old (33 females and 27 males) were selected. For the investigation of reliability and reproducibility of the method, two groups of examiners were established. The first group consisted of 11 orthodontists and the second consisted of 10 radiologists. Each group examined the images and performed individual assessment of the midpalatal suture maturation method twice within an interval of 21 days. During the first and second analyses, the sequence of images was randomized to reduce potential bias. Weighted Cohen's kappa was performed to assess inter- and intra-examiners' agreement. The percentage of perfect agreement and the number of stages apart for each disagreement were calculated. The significance level was P &lt; .05. Results: The overall inter-examiner agreement was satisfactory in the first (kappaw: 0.37) and the second (kappaw: 0.34) analyses. Intra-examiner agreement outcomes were similar between orthodontists (kappaw: 0.44) and radiologists (kappaw: 0.41). The percentage of perfect agreement was 43.2%. Conclusions: The method for individual assessment of midpalatal suture maturation revealed potential reliability and reproducibility. However, the agreement rate observed in the present study was not high enough for a method designed for routine clinical applications.
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42

Lipatov, Vyacheslav A., Dmitriy A. Severinov, Artem A. Denisov, Sergey V. Lazarenko, and Nikolay N. Grigor’yev. "Research of physical and mechanical characteristics of suture material in experiment in operations on liver." I.P. Pavlov Russian Medical Biological Herald 28, no. 2 (July 3, 2020): 193–99. http://dx.doi.org/10.23888/pavlovj2020282193-199.

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Taking into account the peculiarities of the blood supply to the liver and the structure of its parenchyma, and, as a result, considerable difficulties in providing reliable hemostasis without additional traumatization, a surgeon needs to be careful when performing a surgical manipulation. Despite a large number of modern methods for stopping parenchymal bleeding, many practi-tioners give preference to classic methods of hemostasis, including ligation of bleeding vessels in the bulk of the organ using specialized sutures. One of the most serious complications of the use of suture material is cutting of organ tissue, which leads to enhanced bleeding and expansion of the area of damage. At the moment, the tactics of choosing suture material for surgical procedures is empirical. In this context, the aim of this study was to assess the physico-mechanical properties of suture material regarding its structure, and to develop a criterion for choosing surgical sutures for surgical procedures. For the study, the liver was removed out of corpses of males of 35 to 40 years of age, after which separate sections of 7.574 cm in size were obtained from it. Then a wound 3 cm long and 2 cm deep was made. The wound was sutured with a simple interrupted suture without tightening, but with application of one simple half-node. For suturing, catgut, twisted capron and polyglycolide thread were used. Attention was paid to the maximal force applied at the moment of cutting (Fmax) and the degree of pulling the thread at the moment of cutting (Lu). The analysis of the data was based on comparison of Fmax and Lu parameters. This method permits to refuse from the empirical approach to the choice of suture material for operations on the liver, and to develop a criterion for choosing surgical sutures.
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Malik, Sairish, Subramanian Sundarrajan, Tanveer Hussain, Ahsan Nazir, and Seeram Ramakrishna. "Fabrication of Highly Oriented Cylindrical Polyacrylonitrile, Poly(lactide-co-glycolide), Polycaprolactone and Poly(vinyl acetate) Nanofibers for Vascular Graft Applications." Polymers 13, no. 13 (June 24, 2021): 2075. http://dx.doi.org/10.3390/polym13132075.

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Small-diameter vascular grafts fabricated from synthetic polymers have found limited applications so far in vascular surgeries, owing to their poor mechanical properties. In this study, cylindrical nanofibrous structures of highly oriented nanofibers made from polyacrylonitrile, poly (lactide-co-glycolide) (PLGA), polycaprolactone (PCL) and poly(vinyl acetate) (PVAc) were investigated. Cylindrical collectors with alternate conductive and non-conductive segments were used to obtain highly oriented nanofibrous structures at the same time with better mechanical properties. The surface morphology (orientation), mechanical properties and suture retention of the nanofibrous structures were characterized using SEM, mechanical tester and universal testing machine, respectively. The PLGA nanofibrous cylindrical structure exhibited excellent properties (tensile strength of 9.1 ± 0.6 MPa, suture retention strength of 27N and burst pressure of 350 ± 50 mmHg) when compared to other polymers. Moreover, the PLGA grafts showed good porosity and elongation values, that could be potentially used for vascular graft applications. The combination of PLGA nanofibers with extracellular vesicles (EVs) will be explored as a potential vascular graft in future.
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44

Mariappan, N. "Current trends in Nanotechnology applications in surgical specialties and orthopedic surgery." Biomedical & Pharmacology Journal 12, no. 3 (August 7, 2019): 1095–127. http://dx.doi.org/10.13005/bpj/1739.

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Nanotechnology is manipulation of matter on atomic, molecular and supramolecular scale. It has extensive range of applications in various branches of science including molecular biology, Health and medicine, materials, electronics, transportation, drugs and drug delivery, chemical sensing, space exploration, energy, environment, sensors, diagnostics, microfabrication, organic chemistry and biomaterials. Nanotechnology involves innovations in drug delivery,fabric design, reactivity and strength of material and molecular manufacturing. Nanotechnology applications are spread over almost all surgical specialties and have revolutionized treatment of various medical and surgical conditions. Clinically relevant applications of nanotechnology in surgical specialties include development of surgical instruments, suture materials, imaging, targeted drug therapy, visualization methods and wound healing techniques. Management of burn wounds and scar is an important application of nanotechnology.Prevention, diagnosis, and treatment of various orthopedic conditions are crucial aspects of technology for functional recovery of patients. Improvement in standard of patient care,clinical trials, research, and development of medical equipments for safe use are improved with nanotechnology. They have a potential for long-term good results in a variety of surgical specialties including orthopedic surgery in the years to come.
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45

Kim, H. J., D. P. Rice, P. J. Kettunen, and I. Thesleff. "FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development." Development 125, no. 7 (April 1, 1998): 1241–51. http://dx.doi.org/10.1242/dev.125.7.1241.

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The development of calvarial bones is tightly co-ordinated with the growth of the brain and needs harmonious interactions between different tissues within the calvarial sutures. Premature fusion of cranial sutures, known as craniosynostosis, presumably involves disturbance of these interactions. Mutations in the homeobox gene Msx2 as well as the FGF receptors cause human craniosynostosis syndromes. Our histological analysis of mouse calvarial development demonstrated morphological differences in the sagittal suture between embryonic and postnatal stages. In vitro culture of mouse calvaria showed that embryonic, but not postnatal, dura mater regulated suture patency. We next analysed by in situ hybridisation the expression of several genes, which are known to act in conserved signalling pathways, in the sagittal suture during embryonic (E15-E18) and postnatal stages (P1-P6). Msx1 and Msx2 were expressed in the sutural mesenchyme and the dura mater. FGFR2(BEK), as well as Bmp2 and Bmp4, were intensely expressed in the osteogenic fronts and Bmp4 also in the mesenchyme of the sagittal suture and in the dura mater. Fgf9 was expressed throughout the calvarial mesenchyme, the dura mater, the developing bones and the overlying skin, but Fgf4 was not detected in these tissues. Interestingly, Shh and Ptc started to be expressed in patched pattern along the osteogenic fronts at the end of embryonic development and, at this time, the expression of Bmp4 and sequentially those of Msx2 and Bmp2 were reduced, and they also acquired patched expression patterns. The expression of Msx2 in the dura mater disappeared after birth. &lt;P&gt; FGF and BMP signalling pathways were further examined in vitro, in E15 mouse calvarial explants. Interestingly, beads soaked in FGF4 accelerated sutural closure when placed on the osteogenic fronts, but had no such effect when placed on the mid-sutural mesenchyme. BMP4 beads caused an increase in tissue volume both when placed on the osteogenic fronts and on the mid-sutural area, but did not effect suture closure. BMP4 induced the expression of both Msx1 and Msx2 genes in sutural tissue, while FGF4 induced only Msx1. We suggest that the local application of FGF on the osteogenic fronts accelerating suture closure in vitro, mimics the pathogenesis of human craniosynostosis syndromes in which mutations in the FGF receptor genes apparently cause constitutive activation of the receptors. Taken together, our data suggest that conserved signalling pathways regulate tissue interactions during suture morphogenesis and intramembranous bone formation of the calvaria and that morphogenesis of mouse sagittal suture is controlled by different molecular mechanisms during the embryonic and postnatal stages. Signals from the dura mater may regulate the maintenance of sutural patency prenatally, whereas signals in the osteogenic fronts dominate after birth.
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46

Park, Jeongwoo, Byullee Park, Tae Yeong Kim, Sungjin Jung, Woo June Choi, Joongho Ahn, Dong Hee Yoon, et al. "Quadruple ultrasound, photoacoustic, optical coherence, and fluorescence fusion imaging with a transparent ultrasound transducer." Proceedings of the National Academy of Sciences 118, no. 11 (March 8, 2021): e1920879118. http://dx.doi.org/10.1073/pnas.1920879118.

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Ultrasound and optical imagers are used widely in a variety of biological and medical applications. In particular, multimodal implementations combining light and sound have been actively investigated to improve imaging quality. However, the integration of optical sensors with opaque ultrasound transducers suffers from low signal-to-noise ratios, high complexity, and bulky form factors, significantly limiting its applications. Here, we demonstrate a quadruple fusion imaging system using a spherically focused transparent ultrasound transducer that enables seamless integration of ultrasound imaging with photoacoustic imaging, optical coherence tomography, and fluorescence imaging. As a first application, we comprehensively monitored multiparametric responses to chemical and suture injuries in rats’ eyes in vivo, such as corneal neovascularization, structural changes, cataracts, and inflammation. As a second application, we successfully performed multimodal imaging of tumors in vivo, visualizing melanomas without using labels and visualizing 4T1 mammary carcinomas using PEGylated gold nanorods. We strongly believe that the seamlessly integrated multimodal system can be used not only in ophthalmology and oncology but also in other healthcare applications with broad impact and interest.
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47

Eppley, Barry L., James M. Platis, and A. Michael Sadove. "Experimental Effects of Bone Plating in Infancy on Craniomaxillofacial Skeletal Growth." Cleft Palate-Craniofacial Journal 30, no. 2 (March 1993): 164–69. http://dx.doi.org/10.1597/1545-1569_1993_030_0164_eeobpi_2.3.co_2.

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The potential effects of mini- and microfixation on craniofacial development was investigated in an animal model. Twenty-four rabbits had amalgam markers placed bilaterally at the lambdoid, coronal, and frontonasal sutures at 28 days of age. In group 1, plating was not done and served as controls. In groups 2 to 4, single 2- and 4-hole microplates and 4-hole miniplates were fixed across the left coronal suture. The right suture was not plated. After 6 months, intermarker distances and craniofacial angles were measured radiographically. Coronal sutures underneath the plates were also histologically evaluated. Plating across the coronal suture resulted in local anteroposterior constriction of marker distances that did not differ with the type of fixation used. More distant markers, however, were increased in all specimens as a compensation and, as a result, the cranionasal length of all groups were similar. No change in craniofacial angles was observed from that of the controls. Sutural morphology on the side of fixation was altered with decreased widths, cellular numbers, and bone deposition. These experimental results demonstrate that early plate application in a normal calvarium results in local growth restriction that can be overcome by regional bone growth compensation.
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48

Rajan, Krishna Prasad, Ahmed Al-Ghamdi, Ramesh Parameswar, and G. B. Nando. "Blends of Thermoplastic Polyurethane and Polydimethylsiloxane Rubber: Assessment of Biocompatibility and Suture Holding Strength of Membranes." International Journal of Biomaterials 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/240631.

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In the present investigation, a compatibilized blend of thermoplastic polyurethane (TPU) and polydimethylsiloxane (PDMS) is prepared by using copolymer of ethylene and methyl acrylate (EMA) as a reactive compatibilizer. Detailedin vitrobiocompatibility studies were carried out for this compatibilized blend and the material was found noncytotoxic towards L929 mouse fibroblast subcutaneous connective tissue cell line. Microporosity was created on the surface of membranes prepared from the blend material by adopting the crazing mechanism. Cell proliferation and growth studies on the membranes surface showed that the microporous surface favoured ingrowth of the cells compared with a nonmicroporous surface. Suture holding strength studies indicate that the microporous membranes have enough strength to withstand the cutting and tearing forces through the suture hole. This blend material could be evaluated further to find its suitability in various implant applications.
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49

Cho, Sung Bum, Hyoung Rae Kim, Eui-Chul Jung, Hwan Hoon Chung, Seung Hwa Lee, Beom Jin Park, and Deuk Jae Sung. "The application of a vascular closure device for closing a gastrostomy opening used for procedural access." British Journal of Radiology 92, no. 1099 (July 2019): 20180837. http://dx.doi.org/10.1259/bjr.20180837.

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Objective: To study the feasibility of applying the Perclose ProGlide vascular closure device (PPVCD) in vitro for closing a gastrostomy opening for procedural access in the swine stomach in order to prevent peritoneal leakage. Methods: The study included four experimental groups: one manual suture (n = 10), two manual sutures (n = 10), one PPVCD suture (n = 10), and two PPVCD sutures (n = 5). In the two PPVCD sutures group, the “pre-close” technique was used. The leak pressure was measured, and statistical analysis was conducted to compare the leak pressures among the experimental groups. Results: The gastrostomy openings were successfully closed in all experimental groups. The median (range) values of leak pressure (mmHg) for each experimental group were as follows: one manual suture, 86.0 (75.0–110.0); two manual sutures, 98.5 (44.0–130.0); one PPVCD suture, 96.5 (56.0–119.0); and two PPVCD sutures, 98.0 (66.0–104.0). The Mann–Whitney U test revealed no statistically significant difference in leak pressure between the manual (n = 20) and PPVCD (n = 15) suture groups. The Kruskal–Wallis test revealed no statistically significant difference in leak pressure among the four experimental groups. The Bonferroni post hoc test also revealed no statistically significant difference in the pairwise comparisons among the groups. Conclusion: Application of PPVCD is feasible for the closure of gastrostomy openings in an animal model and is as effective as a manual suture. Advances in knowledge: In our in vitro study, percutaneous closure of gastrostomy opening using PPVCD was possible; animal survival studies and development of specific devices are needed before clinical application.
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50

Zhang, Shao Qing, Jiang Yuan Hou, and Guo Qiang Wang. "The Application of Absorbable Suture Materials and Tissue Engineering on Renovation of Exercise-Induced Anadesma Injury." Advanced Materials Research 676 (March 2013): 56–59. http://dx.doi.org/10.4028/www.scientific.net/amr.676.56.

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The ligament injury is the common sport injury in the athletic sports training, the progress and development of suture technique provides a good guarantee for the treatment of tear and rupture tendon, ligament tissue units, the use of absorbable suture materials can prevent in partly risk of Treatment induced by no absorbable suture materials. Therefore, the absorbable suture materials are generally favored by both doctors and patients. The absorbable sutures can be degraded into soluble product in the body, thereby it reducing the patients with second operation pain and minimize patient suture in scar formation, it get the more and more favor of both doctors and patients. The different materials of absorbable sutures were appeared, which meet the people's needs to some extend.
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