Journal articles on the topic 'Sutton-Smith'

Play is children's work: “… play, games and cognitive development are functionally related” (Sutton-Smith 1971, 258). Children eveywhere, in every time period, from every culture and economic class enjoy playing with toys. Toys are learning tools; whether handmade or commercially produced, they help children prepare for their adult lives. Children's toys are frequently small-scale representations of objects from the adult world.

The focus of this themed section is on identifying gaps in anti-poverty policy towards children and young people. The idea to address this question originated at the conference ‘A Fairer Society? A Review of Policies for Vulnerable Groups’ organised by the Centre for Research in Social Policy (CRSP) at Loughborough University in September 2006. The section offers a combination of papers from the conference (Bradshaw and Richardson; Smith; Sutton) and papers commissioned specifically to deal with gaps in anti-poverty policy towards children and young people (Lloyd; France; Phung). An overview of some useful sources has also been included (Davis and Sandu).

Stratigraphic cross-sections, or horizontally extended representations of strata in profile, were introduced into scientific literature in the year 1719 by John Strachey, of Sutton Court, near Stowey Somersetshire, England. Before that time, English-language stratigraphical geology had been practised chiefly by drillers searching for coal, whose published records of vertical sequences of strata and of lateral correlations among subsurface borehole sections, go back to 1639. Strachey's sections were new in several ways: they were drawings rather than lists of strata, they represented true dips, and most importantly they demonstrated stratigraphic correlation in the subsurface and across landscape gaps, where for structural or topographic reasons the intervening strata were obscured or missing. To achieve such delineations in the form of drawings or “draughts”, Strachey assumed as selfevident that the strata were regular in their order of superposition and that they had lateral continuity through concealed areas. His published observations and measurements were widely copied, and William Smith, generally regarded as one of the fathers of geology, seems to have found significant inspiration among Strachey's writings.

In animal housing ammonia is an aerial pollutant resulting from the microbial conversion of nitrogenous materials excreted in faeces and urine. Ammonia is an irritant to cells lining the respiratory tract and an increased incidence of pneumonia in pigs and humans and atrophic rhinitis in pigs have been correlated with elevated ammonia levels. In a survey of 12 farms and 49 pig buildings concentration of ammonia was identified specifically as a causative agent in the aetiology of atrophic rhinitis (Robertson, Wilson and Smith 1990). Furthermore, high levels of ammonia can delay the onset of puberty in gilts perhaps as a result of the masking of boar odour (Malayer, Brandt, Green, Kelly, Sutton and Diekman 1988).Regulations have been introduced (Control of Substances Hazardous to Health (COSHH)) limiting the exposure of humans to atmospheric ammonia to a mean level of 25 ppm over an 8h work shift and 35 ppm for 10 minute exposure. As part of a study on the effectiveness of a feed additive formulated to control atmospheric ammonia, levels of ammonia in pig housing were monitored.

Employees‘ perceptions of the emotional requirements of their work role are considered a necessary antecedent of emotion work. The impact of these requirements on the emotions employees display, their well-being, and their clients' satisfaction has been explored in previous research. Emotional requirements have been characterized as organizationally-based expectations (e.g., Brotheridge & Lee, 2003), formal and informal organizational rules (e.g., Cropanzano, Weiss & Elias, 2004), occupational norms (e.g., Rafaeli & Sutton, 1987; Smith & Kleinman, 1989) and job-based demands (Brotheridge & Lee, 2002). Although all these definitions assume some kind of shared source for perceptions of emotional requirements, it remains unclear to what extent these different sources contribute and to what extent the requirements are shared by different units, teams and individuals in the organization. The present study analyses the perception of emotional requirements from a survey of ninety-seven Primary Health Care teams composed of general practitioners, nurses and administrative staff (N = 1057). The relative contribution of different sources of variance (team, organizational, and occupational) to perceived emotional requirements and the effects on employees’ job satisfaction and well being are examined. Results confirm the relevance of the source and show the contribution of emotional demands to prediction of emotional exhaustion and job satisfaction levels.

A comparative analysis of the philosophical foundations of the teachings on love by Maximus the Confessor and Vladimir Solovyov is presented utilizing the principles of source analysis, comparative philosophical study, and the historico-genetic method. The case is made for the relevance of this research topic, due to the lack of special studies on the reception of Maximus the Confessor’s doctrine of the love in the works of Vladimir Solovyov. An analysis is given of the extent to which V.V. Vysheslavtseva, K.V. Mochulsky, G.V. Florovsky, A.F. Loseva, S.S. Averintseva, V.M. Lurie, I.B. Benevich, A.I. Sidorova knew of the the problem. The focus is also on the works of foreign authors – H.U. von Balthazar, M.-J. Guillau, D.D. Kornblatt, R.F. Gustafson, E.V. Borisova, J.-K. Larcher, Ts. Angelova, J. Sutton, J. Krasicki, O. Smith – which show a genetic affinity between the teachings of Maximus the Confessor and Vladimir Solovyov. This article also takes up the main sources that reveal the content of the concepts of love in Maximus the Confessor and Vladimir Solovyov. Also taken up here is the extent of the Russian philosopher’s acquaintance with the works and heritage of St. Maximus and Solovyov’s assessment of his place and role in the patristic heritage. We find the focus of attention of modern scholars to be on the epistemological and ethical aspects of love as found in the works of the Byzantine thinker. This article also notes the particular importance of studying the ontological foundations of the concepts of love that are found in Maximus the Confessor and Vladimir Solovyov.

X-Linked Protocadherin 19 Mutations Cause Female-Limited Epilepsy and Cognitive Impairment. Dibbens LM, Tarpey PS, Hynes K, Bayly MA, Scheffer IE, Smith R, Bomar J, Sutton E, Vandeleur L, Shoubridge C, Edkins S, Turner SJ, Stevens C, O'Meara S, Tofts C, Barthorpe S, Buck G, Cole J, Halliday K, Jones D, Lee R, Madison M, Mironenko T, Varian J, West S, Widaa S, Wray P, Teague J, Dicks E, Butler A, Menzies A, Jenkinson A, Shepherd R, Gusella JF, Afawi Z, Mazarib A, Neufeld MY, Kivity S, Lev D, Lerman-Sagie T, Korczyn AD, Derry CP, Sutherland GR, Friend K, Shaw M, Corbett M, Kim HG, Geschwind DH, Thomas P, Haan E, Ryan S, McKee S, Berkovic SF, Futreal PA, Stratton MR, Mulley JC, Gecz J. Nat Genetics 2008;40(6):776–781. Epilepsy and mental retardation limited to females (EFMR) is a disorder with an X-linked mode of inheritance and an unusual expression pattern. Disorders arising from mutations on the X chromosome are typically characterized by affected males and unaffected carrier females. In contrast, EFMR spares transmitting males and affects only carrier females. Aided by systematic resequencing of 737 X chromosome genes, we identified different protocadherin 19 ( PCDH19) gene mutations in seven families with EFMR. Five mutations resulted in the introduction of a premature termination codon. Study of two of these demonstrated nonsense-mediated decay of PCDH19 mRNA. The two missense mutations were predicted to affect adhesiveness of PCDH19 through impaired calcium binding. PCDH19 is expressed in developing brains of human and mouse and is the first member of the cadherin superfamily to be directly implicated in epilepsy or mental retardation.

INTRODUCTION: Numerous issues in mental health benefit from technological innovation. An example involves the mental health challenges of long-duration spaceflight (such as a Mars mission), including prolonged confinement, microgravity, and different sunlight exposure lengths. Persisting on Earth are global mental health challenges stemming from disease burdens, limited interview-based diagnostic systems, trial-and-error treatment approaches, and suboptimal access. There is potential for cross-pollinating solutions between these seemingly disparate challenges using a range of emerging technologies such as sensors, omics, and big data. In this review, we highlight the bidirectional value of mental health technology transfer aimed to address issues both on Earth and in space.METHODS: We prepared a systematic review of studies pertaining to mental health technological innovation and space medicine.RESULTS: For Earth mental health technologies translatable to long-duration space missions, we cite several example technologies, including device-based psychotherapy and social support, conversational agents aka chatbots, and nutritional and physical activity focused mental health. Space technologies translatable to Earth mental health include remote sensing devices, global navigation satellite systems, satellite communications, chronotherapies, and nutritional advances.DISCUSSION: There is a rich history of space technologies informing Earth technological trends, including general health care on Earth, and vice versa. To avoid the traditional happenstance approach that results in delays, missed opportunities, and increased cost, and to improve outcomes for both Earth and space utilization of these technologies, we propose increased dialogue and training opportunities to enhance innovation and outcomes.Chang DD, Storch EA, Black L, Berk M, Pellis N, Lavretsky H, Sutton J, Ternes K, Shepanek M, Smith E, Abbott R, Eyre HA. Promoting tech transfer between space and global mental health. Aerosp Med Hum Perform. 2020; 91(9):737745.

Frederick H. Smith; Caribbean Rum: A Social and Economic History (Franklin W. Knight)Stephan Palmié; Wizards and Scientists: Explorations in Afro-Cuban Modernity and Tradition (Julie Skurski)Miguel A. De la Torre; The Quest for the Cuban Christ: A Historical Search (Fernando Picó)L. Antonio Curet, Shannon Lee Dawdy & Gabino La Rosa Corzo (eds.); Dialogues in Cuban Archaeology (David M. Pendergast)Jill Lane; Blackface Cuba, 1840-1895 (Arthur Knight)Hal Klepak; Cuba’s Military 1990-2005: Revolutionary Soldiers during Counter-Revolutionary Times (Antoni Kapcia)Lydia Chávez (ed.); Capitalism, God, and a Good Cigar: Cuba Enters the Twenty-First Century (Ann Marie Stock)Diane Accaria-Zavala & Rodolfo Popelnik (eds.); Prospero’s Isles: The Presence of the Caribbean in the American Imaginary (Sean X. Goudie)Alexandra Isfahani-Hammond (ed.); The Masters and the Slaves: Plantation Relations and Mestizaje in American Imaginaries (Danielle D. Smith) David J. Weber; Bárbaros: Spaniards and Their Savages in the Age of Enlightenment (Neil L. Whitehead)Larry Gragg; Englishmen Transplanted: The English Colonization of Barbados, 1627-1660 (Richard S. Dunn)Jon F. Sensbach; Rebecca’s Revival: Creating Black Christianity in the Atlantic World (Aaron Spencer Fogleman)Jennifer L. Morgan; Laboring Women: Reproduction and Gender in New World Slavery (Verene A. Shepherd)Jorge Luis Chinea; Race and Labor in the Hispanic Caribbean: The West Indian Immigrant Worker Experience in Nineteenth-Century Puerto Rico, 1800-1850 (Juan José Baldrich)Constance R. Sutton (ed.); Revisiting Caribbean Labour: Essays in Honour of O. Nigel Bolland (Mary Chamberlain)Gert Oostindie; Paradise Overseas: The Dutch Caribbean: Colonialism and its Transatlantic Legacies (Bridget Brereton)Allan Pred; The Past Is Not Dead: Facts, Fictions, and Enduring Racial Stereotypes (Karen Fog Olwig)James C. Riley; Poverty and Life Expectancy: The Jamaica Paradox (Cruz María Nazario)Lucia M. Suárez; The Tears of Hispaniola: Haitian and Dominican Diaspora Memory (J. Michael Dash)Mary Chamberlain; Family Love in the Diaspora: Migration and the Anglo-Caribbean Experience (Kevin Birth)Joseph Palacio (ed.); The Garifuna: A Nation Across Borders (Grant Jewell Rich)Elizabeth M. DeLoughery, Renée K. Goss on & George B. Handley (eds.); Caribbean Literature and the Environment: Between Nature and Culture (Bonham C. Richardson)Mary Gallagher (ed.); Ici-Là: Place and Displacement in Caribbean Writing in French (Christina Kullberg)David V. Moskowitz; Caribbean Popular Music: An Encyclopedia of Reggae, Mento, Ska, Rock Steady, and Dancehall (Kenneth Bilby)John H. McWhorter; Defining Creole (Bettina M. Migge)Ellen M. Schnepel; In Search of a National Identity: Creole and Politics in Guadeloupe (Paul B. Garrett)

Frederick H. Smith; Caribbean Rum: A Social and Economic History (Franklin W. Knight)Stephan Palmié; Wizards and Scientists: Explorations in Afro-Cuban Modernity and Tradition (Julie Skurski)Miguel A. De la Torre; The Quest for the Cuban Christ: A Historical Search (Fernando Picó)L. Antonio Curet, Shannon Lee Dawdy & Gabino La Rosa Corzo (eds.); Dialogues in Cuban Archaeology (David M. Pendergast)Jill Lane; Blackface Cuba, 1840-1895 (Arthur Knight)Hal Klepak; Cuba’s Military 1990-2005: Revolutionary Soldiers during Counter-Revolutionary Times (Antoni Kapcia)Lydia Chávez (ed.); Capitalism, God, and a Good Cigar: Cuba Enters the Twenty-First Century (Ann Marie Stock)Diane Accaria-Zavala & Rodolfo Popelnik (eds.); Prospero’s Isles: The Presence of the Caribbean in the American Imaginary (Sean X. Goudie)Alexandra Isfahani-Hammond (ed.); The Masters and the Slaves: Plantation Relations and Mestizaje in American Imaginaries (Danielle D. Smith) David J. Weber; Bárbaros: Spaniards and Their Savages in the Age of Enlightenment (Neil L. Whitehead)Larry Gragg; Englishmen Transplanted: The English Colonization of Barbados, 1627-1660 (Richard S. Dunn)Jon F. Sensbach; Rebecca’s Revival: Creating Black Christianity in the Atlantic World (Aaron Spencer Fogleman)Jennifer L. Morgan; Laboring Women: Reproduction and Gender in New World Slavery (Verene A. Shepherd)Jorge Luis Chinea; Race and Labor in the Hispanic Caribbean: The West Indian Immigrant Worker Experience in Nineteenth-Century Puerto Rico, 1800-1850 (Juan José Baldrich)Constance R. Sutton (ed.); Revisiting Caribbean Labour: Essays in Honour of O. Nigel Bolland (Mary Chamberlain)Gert Oostindie; Paradise Overseas: The Dutch Caribbean: Colonialism and its Transatlantic Legacies (Bridget Brereton)Allan Pred; The Past Is Not Dead: Facts, Fictions, and Enduring Racial Stereotypes (Karen Fog Olwig)James C. Riley; Poverty and Life Expectancy: The Jamaica Paradox (Cruz María Nazario)Lucia M. Suárez; The Tears of Hispaniola: Haitian and Dominican Diaspora Memory (J. Michael Dash)Mary Chamberlain; Family Love in the Diaspora: Migration and the Anglo-Caribbean Experience (Kevin Birth)Joseph Palacio (ed.); The Garifuna: A Nation Across Borders (Grant Jewell Rich)Elizabeth M. DeLoughery, Renée K. Goss on & George B. Handley (eds.); Caribbean Literature and the Environment: Between Nature and Culture (Bonham C. Richardson)Mary Gallagher (ed.); Ici-Là: Place and Displacement in Caribbean Writing in French (Christina Kullberg)David V. Moskowitz; Caribbean Popular Music: An Encyclopedia of Reggae, Mento, Ska, Rock Steady, and Dancehall (Kenneth Bilby)John H. McWhorter; Defining Creole (Bettina M. Migge)Ellen M. Schnepel; In Search of a National Identity: Creole and Politics in Guadeloupe (Paul B. Garrett)

Cedrus deodara is a highly valued conifer widely grown as an ornamental in the Pacific Northwest and southern United States. C. deodara in the Pacific Northwest is normally problem free but occasionally is damaged by dieback of shoot tips, which has been associated with a fungus resembling Sirococcus conigenus. In February 2002, bleeding cankers were observed on 2- to 4-year-old stems of potted nursery stock of C. deodara cv. Karl Fuchs from Clackamas County, OR. Cankers were dark with indistinct margins, shallow, and up to 30 cm long. Infection appeared to have originated with small twigs that had died. Cultures isolated from discolored bark on streptomycin-amended potato dextrose agar (PDA) produced conidiomata with hyaline, fusiform, two-celled conidia typical of S. conigenus (1,3). Inter-simple sequence repeat-polymerase chain reaction fingerprints of an isolate from one of these trees were consistent with the P group of S. conigenus (mostly from hosts in Picea and Pinus spp.) (2). This isolate (02–04, ATCC MYA-2969) was used to inoculate two shoots on each of 12 3-year-old potted deodar cedars in each of two trials. Removing a needle wounded each shoot, and an agar plug colonized with mycelium was placed over the wound and held in place for 2 weeks with Parafilm. Sterile agar plugs were applied to two wounded control shoots on each tree in each trial. After 10 weeks, 25 of 48 inoculated shoots were blighted and drooped with yellow to brown needles that eventually dropped. The pathogen was reisolated from 24 of 25 symptomatic shoots but not from asymptomatic or control shoots. To our knowledge, this is the first confirmed report of S. conigenus as a pathogen of C. deodara. References: (1) P. F. Cannon and D. W. Minter. Taxon 32:572, 1983. (2) D. R. Smith et al. For. Pathol. 33:141, 2003. (3) B. Sutton. The Coelomycetes. Commonw. Mycol. Inst., Kew, Surrey, England, 1980.

-John Parker, Norman J.W. Thrower, Sir Francis Drake and the famous voyage, 1577-1580. Los Angeles: University of California Press, Contributions of the UCLA Center for Medieval and Renaissance Studies Vol. 11, 1984. xix + 214 pp.-Franklin W. Knight, B.W. Higman, Trade, government and society in Caribbean history 1700-1920. Kingston: Heinemann Educational Books, 1983. xii + 172 pp.-A.J.R. Russel-Wood, Lyle N. McAlister, Spain and Portugal in the New World, 1492-1700. Minneapolis, University of Minnesota Press, Europe and the World in the Age of Expansion Volume III, 1984. xxxi + 585 pp.-Tony Martin, John Gaffar la Guerre, The social and political thought of the colonial intelligentsia. Mona, Jamaica: Institute of Social and Economic Research, University of the West Indies, 1982. 136 pp.-Egenek K. Galbraith, Raymond T. Smith, Kinship ideology and practice in Latin America. Chapel Hill NC: University of North Carolina Press, 1984. 341 pp.-Anthony P. Maingot, James Pack, Nelson's blood: the story of naval rum. Annapolis MD, U.S.A.: Naval Institute Press and Havant Hampshire, U.K.: Kenneth Mason, 1982. 200 pp.-Anthony P. Maingot, Hugh Barty-King ,Rum: yesterday and today. London: William Heineman, 1983. xviii + 264 pp., Anton Massel (eds)-Helen I. Safa, Alejandro Portes ,Latin journey: Cuban and Mexican immigrants in the United States. Berkeley: University of California Press, 1985. xxi + 387 pp., Robert L. Bach (eds)-Wayne S. Smith, Carlos Franqui, Family portrait wth Fidel: a memoir. New York: Random House, 1984. xxiii + 263 pp.-Sergio G. Roca, Claes Brundenius, Revolutionary Cuba: the challenge of economic growth with equity. Boulder CO: Westview Press and London: Heinemann, 1984. xvi + 224 pp.-H. Hoetink, Bernardo Vega, La migración española de 1939 y los inicios del marxismo-leninismo en la República Dominicana. Santo Domingo: Fundación Cultural Dominicana, 1984. 208 pp.-Antonio T. Díaz-Royo, César Andreú-Iglesias, Memoirs of Bernardo Vega: a contribution to the history of the Puerto Rican community in New York. Translated by Juan Flores. New York and London: Monthly Review, 1984. xix + 243 pp.-Mariano Negrón-Portillo, Harold J. Lidin, History of the Puerto Rican independence movement: 20th century. Maplewood NJ; Waterfront Press, 1983. 250 pp.-Roberto DaMatta, Teodore Vidal, Las caretas de cartón del Carnaval de Ponce. San Juan: Ediciones Alba, 1983. 107 pp.-Manuel Alvarez Nazario, Nicolás del Castillo Mathieu, Esclavos negros en Cartagena y sus aportes léxicos. Bogotá: Institute Caro y Cuervo, 1982. xvii + 247 pp.-J.T. Gilmore, P.F. Campbell, The church in Barbados in the seventeenth century. Garrison, Barbados; Barbados Museum and Historical Society, 1982. 188 pp.-Douglas K. Midgett, Neville Duncan ,Women and politics in Barbados 1948-1981. Cave Hill, Barbados: Institute of Social and Economic Research (Eastern Caribbean), Women in the Caribbean Project vol. 3, 1983. x + 68 pp., Kenneth O'Brien (eds)-Ken I. Boodhoo, Maurice Bishop, Forward ever! Three years of the Grenadian Revolution. Speeches of Maurice Bishop. Sydney: Pathfinder Press, 1982. 287 pp.-Michael L. Conniff, Velma Newton, The silver men: West Indian labour migration to Panama, 1850-1914. Kingston: Institute of Social and Economic Research, University of the West Indies, 1984. xx + 218 pp.-Robert Dirks, Frank L. Mills ,Christmas sports in St. Kitts: our neglected cultural tradition. With lessons by Bertram Eugene. Frederiksted VI: Eastern Caribbean Institute, 1984. iv + 66 pp., S.B. Jones-Hendrickson (eds)-Catherine L. Macklin, Virginia Kerns, Woman and the ancestors: Black Carib kinship and ritual. Urbana IL: University of Illinois Press, 1983. xv + 229 pp.-Marian McClure, Brian Weinstein ,Haiti: political failures, cultural successes. New York: Praeger (copublished with Hoover Institution Press, Stanford), 1984. xi + 175 pp., Aaron Segal (eds)-A.J.F. Köbben, W.S.M. Hoogbergen, De Boni-oorlogen, 1757-1860: marronage en guerilla in Oost-Suriname (The Boni wars, 1757-1860; maroons and guerilla warfare in Eastern Suriname). Bronnen voor de studie van Afro-amerikaanse samenlevinen in de Guyana's, deel 11 (Sources for the Study of Afro-American Societies in the Guyanas, no. 11). Dissertation, University of Utrecht, 1985. 527 pp.-Edward M. Dew, Baijah Mhango, Aid and dependence: the case of Suriname, a study in bilateral aid relations. Paramaribo: SWI, Foundation in the Arts and Sciences, 1984. xiv + 171 pp.-Edward M. Dew, Sandew Hira, Balans van een coup: drie jaar 'surinaamse revolutie.' Rotterdam: Futile (Blok & Flohr), 1983. 175 pp.-Ian Robertson, John A. Holm ,Dictionary of Bahamian English. New York: Lexik House Publishers, 1982. xxxix + 228 pp., Alison Watt Shilling (eds)-Erica Williams Connell, Paul Sutton, Commentary: A reply from Williams Connell (to the review by Anthony Maingot in NWIG 57:89-97).

Phoma black leg or stem canker, caused by Leptosphaeria maculans or L. biglobosa, is an important disease of brassicas, causing significant crop losses in areas such as Europe, Australia, and North America (1). Samples collected in 2011 from canola and forage brassica (swede, kale, and turnip) crops in the main New Zealand growing regions (Southland, Central Otago, Canterbury, Hawkes Bay, and Manawatu) to identify the causal agent(s) of the characteristic stem cankers, found many isolates of L. maculans, which has been reported previously in New Zealand (2), and three isolates identified by colony characteristics as L. biglobosa. Of the latter, two isolates were from canola (Brassica napus) stem cankers from Darfield and Lincoln, Canterbury, and one was from a kale (B. oleracea) stem canker from Lincoln. An isolate (ICMP10665) of similar morphology, from the International Collection of Microorganisms from Plants (ICMP), obtained from a basal rot lesion on a cauliflower (B. oleracea var. botrytis) plant in Levin, New Zealand in 1979, was also evaluated. The initial, incorrect identification of the latter isolate as L. maculans predates the reclassification of L. maculans group B isolates as a new species, L. biglobosa (1). These four isolates produced fluffy white mycelium and a yellow pigment on potato dextrose agar (PDA) after 5 days' growth, and abundant black-brown, globose pycnidia containing cylindrical hyaline conidia after 7 days. In contrast, L. maculans isolates had slower growth and no pigment production (4). Amplification of genomic DNA using species-specific primers LmacR, LmacF, and LbigF (1) generated a PCR product of 444 bp that is typical of L. biglobosa isolates. Sequencing of the PCR product from each of the four isolates showed they were 100% identical to a sequence of L. biglobosa ‘brassicae’ in GenBank (JF740198). To confirm the species identity of the isolates, the rDNA, actin, and β-tubulin gene regions were amplified (1,3). Sequences for the rDNA (568 bp), actin (941 bp), and β-tubulin (410 bp) gene regions were 99% identical to sequences of the same regions of isolates in GenBank for L. biglobosa ‘brassicae’ (AY48997, AY748949.1, and AY748997.1, respectively). The four L. biglobosa isolates were tested for pathogenicity on a canola cultivar commonly grown in New Zealand (Flash). Cotyledons of 10-day-old seedlings (n = 12 seedlings/isolate or control treatment) grown in a potting mix in pots were pricked with a sewing needle, and each wound inoculated with 10 μl of the appropriate conidial suspension (106 conidia/ml) or 10 μl sterilized distilled water for the control treatment. Leaf lesions that developed on the inoculated cotyledons were characteristic of those caused by L. biglobosa, i.e., small and dark with a distinct margin. No pycnidia were produced on the lesions. No lesions developed on the cotyledons of the non-inoculated control plants. The causal agents were confirmed as L. biglobosa by the colony morphology of isolates that grew from surface-sterilized, inoculated leaf lesions plated on PDA amended with 100 μg/ml ampicillin. The fungus was not isolated from control leaf tissue. To our knowledge, this is the first report of L. biglobosa as a pathogen of canola and kale in New Zealand. This finding shows that both causal agents of black leg are present in New Zealand's brassica cropping areas. References: (1) S. Y. Liu et al. Plant Pathol. 55:401, 2006. (2) H. C. Smith and B. C. Sutton. Trans. Brit. Mycol. Soc. 47:159, 1964. (3) L. Vincenot et al. Phytopathology 98:321, 2008. (4) R. H. Williams and B. D. L. Fitt. Plant Pathol. 48:161, 1999.

Italy could be considered the main apple-producing country in the European Union. Italian apple (Malus domestica L. Borkh.) production is estimated at approximately 2.1 million tons and encompasses a wide range of cultivars, harvested from August to November. Colletotrichum acutatum, which causes severe losses to strawberry production, was a regulated organism for all European countries until 2008, when it was removed from the EPPO quarantine pathogen list because of its wide distribution in strawberry-production areas. During the growing season of 2010, fungi were isolated from apple fruits exhibiting bitter rot symptoms after 4 months of storage in several packinghouses in the Emilia Romagna Region. The apples belonged to the Golden Delicious, Granny Smith, Pink Lady and Crisp Pink cultivars. Lesions on the fruit surface were circular and 1 to 3 cm in diameter. When lesions enlarged, they became sunken with relatively firm rotten tissues. The fungal fruiting structures, acervuli, were distributed sparsely or densely on old lesions, and under humid conditions, they discharged an orange conidial mass. Conidia observed with a light microscope appeared hyaline and fusiform, 8 to 16 × 2.5 to 4 μm, with two pointed ends or one rounded end. The fungal isolates were grown on potato dextrose agar (PDA) plates incubated at 25°C. After 7 days, colonies were white, becoming gray to pale orange, and when viewed from the reverse side, the color ranged from pink to reddish orange. Both cultural and morphological characteristics of the pathogen were similar to those described for C. acutatum J.H. Simmonds (3), which is responsible for bitter rot of apple (2). Koch's postulates were performed with one representative isolate from each host by artificial inoculation of 30 healthy apples from the cultivars listed above. Fruit surfaces were disinfected with 70% ethanol, wounded with a sterile needle, and then inoculated with 20 μl of a spore suspension (105 conidia ml–1) prepared from a 15-day-old culture on PDA. Inoculated fruits were sealed in a plastic bag and incubated at 25°C for 10 days. In 92% of fruits, symptoms appeared 10 days later, forming lesions with cream-to-salmon pink fruiting structures. The fungus was reisolated onto PDA from the lesions on the inoculated apples. After 7 days of incubation, the colonies and the morphology of conidia were the same as those of the original isolates. The tests were performed on all four cultivars with similar results. The PCR analysis, carried out using universal primers ITS1 and ITS4 (4) directly from single-spore-derived mycelium (1), resulted in an amplification product with 100% sequence homology with C. acutatum isolate AB626881 from GenBank database. Considering the results obtained, to our knowledge, this is the first report of C. acutatum in Italy causing bitter rot on apple. The disease is common in practically all countries where apples are commercially grown and since the losses could be severe under prolonged warm and wet weather conditions, C. acutatum could represent a serious issue for the Italian apple industry. References: (1) M. Iotti and A. Zambonelli. Mycol. Res. 110:60, 2006. (2) A. L. Jones et al. Plant Dis. 80:1294, 1996. (3) B. C. Sutton. Page 1 in: Colletotrichum: Biology, Pathology and Control. Brit. Soc. Plant Pathol. Oxon. UK 1992. (4) T. J. White et al. Page 315 in: PCR Protocols. A Guide to Methods and Applications. Academic Press, San Diego, CA, 1990.

- R. Anderson Sutton, Wim van Zanten, Ethnomusicology in the Netherlands: present situation and traces of the past. Leiden: Centre of Non-Western Studies, Leiden University, 1995, ix + 330 pp. [Oideion; The performing arts worldwide 2. Special Issue]., Marjolijn van Roon (eds.) - T.E. Behrend, Willem Remmelink, The Chinese War and the collapse of the Javanese state, 1725-1743. Leiden: KITLV Press, 1994, 297 pp. [Verhandelingen 162]. - Erik Brandt, Eric Venbrux, A death in the Tiwi Islands; Conflict, ritual and social life in an Australian Aboriginal Community. Cambridge: Cambridge University Press, 1995, xvii + 269 pp. - Madelon Djajadiningrat-Nieuwenhuis, Tineke Hellwig, In the shadow of change; Images of women in Indonesian literature. Berkeley: University of California, Centers for South and Southeast Asia Studies, 1994, xiii + 259 pp. [Monograph 35]. - M. Estellie Smith, Peter J.M. Nas, Issues in urban development; Case studies from Indonesia. Leiden: Research School CNWS, 1995, 293 pp. [CNWS Publications 33]. - Uta Gärtner, Jan Becka, Historical dictionary of Myanmar. Metuchen, N.J.: Scarecrow Press, xxii + 328 pp. [Asian Historical Dictionaries 15]. - Beatriz van der Goes, H. Slaats, Wilhelm Middendorp over de Karo Batak, 1914-1919. Deel 1. Nijmegen: Katholieke Universiteit, Faculteit der Rechtsgeleerdheid, 1994, xvii + 313 pp. [Reeks Recht en Samenleving 11]., K. Portier (eds.) - Stephen C. Headley, Janet Carsten, About the house, Lévi-Strauss and beyond. Cambridge: Cambridge University Press, 1995, xiv + 300 pp., Stephen Hugh-Jones (eds.) - Stephen C. Headley, James J. Fox, Inside Austronesian houses; Perspectives on domestic designs for living. Canberra: Department of Anthropology, Research School of Pacific Studies, The Australian National University, 1993, x + 237 pp. - M. Hekker, Helmut Buchholt, Continuity, change and aspirations; Social and cultural life in Minahasa, Indonesia. Singapore: Institute of Southeast Asian Studies, 1994, vii + 231 pp., Ulricht Mai (eds.) - Tineke Hellwig, Brigitte Müller, Op de wipstoel; De niet-gewettigde inheemse vrouw van de blanke Europeaan in Nederlands-Indië (1890-1940); Een literatuuronderzoek naar beeldvorming en werkelijkheid. Amsterdam: Vakgroep Culturele Antropologie/Sociologie der Niets-Westerse Samenlevingen, 1995, xii + 131 pp. - Jan van der Putten, Liaw Yock Fang, Standard Malay made simple. Singapore: Times Books International, 1988. - Jan van der Putten, Liaw Yock Fang, Standard Indonesian made simple, written with the assistance of Nini Tiley-Notodisuryo, Singapore: Times Books International, 1990. - Jan van der Putten, Liaw Yock Fang, Speak standard Malay; A beginner’s guide. Singapore: Times Books International, 1993, xxii + 280 pp. - Jan van der Putten, Liaw Yock Fang, Speak Indonesian; A beginner’s guide, written in collaboration with Munadi Padmadiwiria and Abdullah Hassan. Singapore: Times Books International, 1990. - Alle G. Hoekema, Chr.G.F. de Jong, Geschiedenis van de Nederlandse Zending op Zuid-Sulawesi 1852-1966; Een bronnenpublicatie. Oegstgeest: Raad voor de Zending der Nederlands Hervormde Kerk, 1995, xi + 524 pp. - George Hotze, Ronald G. Gill, De Indische stad op Java en Madura; Een morfologische studie van haar ontwikkeling. Delft: Publikatieburo Bouwkunde, Technische Universiteit Delft, 1995, 350 pp. - H.A.J. Klooster, Holk H. Dengel, Neuere Darstellung der Geschichte Indonesiens in Bahasa Inonesia; Entwicklung und Tendenzen der indonesischen Historiographie. Stuttgart: Steiner, 1994, vii + 269 pp. - Harry A. Poeze, Hans Antlöv, Imperial policy and Southeast Asian nationalism 1930-1957. Richmond: Curzon Press, 1995, xiii + 323 pp., Stein Tonnesson (eds.) - P.W. Preston, Michael Hill, The politics of nation building and citizenship in Singapore. London: Routledge, 1995, x + 285 pp., Lian Kwen Fee (eds.) - J.W. (Pim) Schoorl, Michael Southon, The navel of the perahu; Meaning and values in the maritime trading economy of a Butonese village. Canberra: Department of Anthropology, Research School of Pacific and Asian Studies, The Australian National University, 1995, xiv + 150 pp. - Henk Schulte Nordholt, Geoffrey Robinson, The dark side of paradise; Political violence in Bali. Ithaca/London: Cornell University Press, 1995, xxii + 341 pp. - Herman A.O. de Tollenaere, Th. Stevens, Vrijmetselarij en samenleving in Nederlands-Indië en Indonesië 1764-1962. Hilversum: Verloren, 1994, 400 pp. - Donald E. Weatherbee, Mpu Prapañca, Desawarnana (Nagarakrtagama) by Mpu Prapañca, translated and edited by Stuart Robson. Leiden: KITLV Press, 1995, viii + 158 pp. [Verhandelingen 169]. - E.P. Wieringa, Jennifer Lindsay, Kraton Yogyakarta. Diterjemahkan oleh R.M. Soetanto dan T.E. Behrend. Jakarta: Yayasan Obor Indonesia, 1994, xvi + 330 pp. [Seri katalog Induk Naskah-Naskah Nusantara 2]., R.M. Soetanto, Alan Feinstein (eds.) - E.P. Wieringa, Wouter Smit, De islam binnen de horizon; Een missiologische studie over de benadering van de islam door vier Nederlandse zendingscorporaties (1797-1951). Zoetermeer: Boekencentrum, 1995, xix + 312 pp. [MISSION 11].

-Edward L. Cox, Judith A. Carney, Black rice: The African origin of rice cultivation in the Americas. Cambridge MA: Harvard University Press, 2001. xiv + 240 pp.-David Barry Gaspar, Brian Dyde, A history of Antigua: The unsuspected Isle. Oxford: Macmillan Education, 2000. xi + 320 pp.-Carolyn E. Fick, Stewart R. King, Blue coat or powdered wig: Free people of color in pre-revolutionary Saint Domingue. Athens: University of Georgia Press, 2001. xxvi + 328 pp.-César J. Ayala, Birgit Sonesson, Puerto Rico's commerce, 1765-1865: From regional to worldwide market relations. Los Angeles: UCLA Latin American Center Publications, 200. xiii + 338 pp.-Nadine Lefaucheur, Bernard Moitt, Women and slavery in the French Antilles, 1635-1848. Bloomington: Indiana University Press, 2001. xviii + 217 pp.-Edward L. Cox, Roderick A. McDonald, Between slavery and freedom: Special magistrate John Anderson's journal of St. Vincent during the apprenticeship. Jamaica: University of the West Indies Press, 2001. xviii + 309 pp.-Jaap Jacobs, Benjamin Schmidt, Innocence abroad: The Dutch imagination and the new world, 1570-1670. New York: Cambridge University Press, 2001. xxviii + 450 pp.-Wim Klooster, Johanna C. Prins ,The Low countries and the New World(s): Travel, Discovery, Early Relations. Lanham NY: University Press of America, 2000. 226 pp., Bettina Brandt, Timothy Stevens (eds)-Wouter Gortzak, Gert Oostindie ,Knellende koninkrijksbanden: Het Nederlandse dekolonisatiebeleid in de Caraïben, 1940-2000. Volume 1, 1940-1954; Volume 2, 1954-1975; Volume 3, 1975-2000. 668 pp. Amsterdam: Amsterdam University Press, 2001., Inge Klinkers (eds)-Richard Price, Ellen-Rose Kambel, Resource conflicts, gender and indigenous rights in Suriname: Local, national and global perspectives. Leiden, The Netherlands: self-published, 2002, iii + 266.-Peter Redfield, Richard Price ,Les Marrons. Châteauneuf-le-Rouge: Vents d'ailleurs, 2003. 127 pp., Sally Price (eds)-Mary Chamberlain, Glenford D. Howe ,The empowering impulse: The nationalist tradition of Barbados. Kingston: Canoe Press, 2001. xiii + 354 pp., Don D. Marshall (eds)-Jean Stubbs, Alejandro de la Fuente, A Nation for All: Race, Inequality, and Politics in Twentieth-Century Cuba. Chapel Hill: University of North Carolina Press, 2001. xiv + 449 pp.-Sheryl L. Lutjens, Susan Kaufman Purcell ,Cuba: The contours of Change. Boulder CO: Lynne Rienner, 2000. ix + 155 pp., David J. Rothkopf (eds)-Jean-Germain Gros, Robert Fatton Jr., Haiti's predatory republic: The unending transition to democracy. Boulder CO: Lynn Rienner, 2002. xvi + 237 pp.-Elizabeth McAlister, Beverly Bell, Walking on fire: Haitian Women's Stories of Survival and Resistance. Ithaca NY: Cornell University Press, 2001. xx + 253 pp.-Gérard Collomb, Peter Hulme, Remnants of conquest: The island Caribs and their visitors, 1877-1998. Oxford: Oxford University Press, 2000. 371 pp.-Chris Bongie, Jeannie Suk, Postcolonial paradoxes in French Caribbean Writing: Césaire, Glissant, Condé. New York: Oxford University Press, 2001. 216 pp.-Marie-Hélène Laforest, Caroline Rody, The Daughter's return: African-American and Caribbean Women's fictions of history. New York: Oxford University Press, 2001. x + 267 pp.-Marie-Hélène Laforest, Isabel Hoving, In praise of new travelers: Reading Caribbean migrant women's writing. Stanford CA: Stanford University Press, 2001. ix + 374 pp.-Catherine Benoît, Franck Degoul, Le commerce diabolique: Une exploration de l'imaginaire du pacte maléfique en Martinique. Petit-Bourg, Guadeloupe: Ibis Rouge, 2000. 207 pp.-Catherine Benoît, Margarite Fernández Olmos ,Healing cultures: Art and religion as curative practices in the Caribbean and its diaspora. New York: Palgrave, 2001. xxi + 236 pp., Lizabeth Paravisini-Gebert (eds)-Jorge Pérez Rolón, Charley Gerard, Music from Cuba: Mongo Santamaría, Chocolate Armenteros and Cuban musicians in the United States. Westport CT: Praeger, 2001. xi + 155 pp.-Ivelaw L. Griffith, Anthony Payne ,Charting Caribbean Development. Gainesville: University Press of Florida, 2001. xi + 284 pp., Paul Sutton (eds)-Ransford W. Palmer, Irma T. Alonso, Caribbean economies in the twenty-first century. Gainesville: University Press of Florida, 2002. 232 pp.-Glenn R. Smucker, Jennie Marcelle Smith, When the hands are many: Community organization and social change in rural Haiti. Ithaca NY: Cornell University Press, 2001. xii + 229 pp.-Kevin Birth, Nancy Foner, Islands in the city: West Indian migration to New York. Berkeley: University of California Press, 2001. viii + 304 pp.-Joy Mahabir, Viranjini Munasinghe, Callaloo or tossed salad? East Indians and the cultural politics of identity in Trinidad. Ithaca NY: Cornell University Press, 2001. xv + 315 pp.-Stéphane Goyette, Robert Chaudenson, Creolization of language and culture. Revised in collaboration with Salikoko S. Mufwene. London: Routledge, 2001. xxi + 340 pp.

-Jay B. Haviser, Jerald T. Milanich ,First encounters: Spanish explorations in the Caribbean and the United States, 1492-1570. Gainesville FL: Florida Museum of Natural History & University Presses of Florida, 1989. 221 pp., Susan Milbrath (eds)-Marvin Lunenfeld, The Libro de las profecías of Christopher Columbus: an en face edition. Delano C. West & August Kling, translation and commentary. Gainesville FL: University of Florida Press, 1991. x + 274 pp.-Suzannah England, Charles R. Ewen, From Spaniard to Creole: the archaeology of cultural formation at Puerto Real, Haiti. Tuscaloosa AL; University of Alabama Press, 1991. xvi + 155 pp.-Piero Gleijeses, Bruce Palmer Jr., Intervention in the Caribbean: the Dominican crisis of 1965. Lexington KY: University Press of Kentucky, 1989.-Piero Gleijeses, Herbert G. Schoonmaker, Military crisis management: U.S. intervention in the Dominican Republic, 1965. Westport CT: Greenwood Press, 1990. 152 pp.-Jacqueline A. Braveboy-Wagner, Fitzroy André Baptiste, War, cooperation, and conflict: the European possessions in the Caribbean, 1939-1945. Westport CT: Greenwood Press, 1988. xiv + 351 pp.-Peter Meel, Paul Sutton, Europe and the Caribbean. London: Macmillan Caribbean, 1991. xii + 260 pp.-Peter Meel, Betty Secoc-Dahlberg, The Dutch Caribbean: prospects for democracy. New York: Gordon and Breach, 1990. xix + 333 pp.-Michiel Baud, Rosario Espinal, Autoritarismo y democracía en la política dominicana. San José, Costa Rica: Ediciones CAPEL, 1987. 208 pp.-A.J.G. Reinders, J.M.R. Schrils, Een democratie in gevaar: een verslag van de situatie op Curacao tot 1987. Assen, Maastricht: Van Gorcum, 1990. xii + 292 pp.-Andrés Serbin, David W. Dent, Handbook of political science research on Latin America: trends from the 1960s to the 1990s. Westport CT: Greenwood, 1990.-D. Gail Saunders, Dean W. Collinwood, The Bahamas between worlds. Decatur IL: White Sound Press, 1989. vii + 119 pp.-D. Gail Saunders, Dean W. Collinwood ,Modern Bahamian society. Parkersburg IA: Caribbean Books, 1989. 278 pp., Steve Dodge (eds)-Peter Hulme, Pierrette Frickey, Critical perspectives on Jean Rhys. Washington DC: Three Continents Press, 1990. 235 pp.-Alvina Ruprecht, Lloyd W. Brown, El Dorado and Paradise: Canada and the Caribbean in Austin Clarke's fiction. Parkersburg IA: Caribbean Books, 1989. xv + 207 pp.-Ineke Phaf, Michiel van Kempen, De Surinaamse literatuur 1970-1985: een documentatie. Paramaribo: Uitgeverij de Volksboekwinkel, 1987. 406 pp.-Genevieve Escure, Barbara Lalla ,Language in exile: three hundred years of Jamaican Creole. Tuscaloosa AL: University of Alabama Press, 1990. xvii + 253 pp., Jean D'Costa (eds)-Charles V. Carnegie, G. Llewellyn Watson, Jamaican sayings: with notes on folklore, aesthetics, and social control.Tallahassee FL: Florida A & M University Press, 1991. xvi + 292 pp.-Donald R. Hill, Kaiso, calypso music. David Rudder in conversation with John La Rose. London: New Beacon Books, 1990. 33 pp.-Mark Sebba, John Victor Singler, Pidgin and creole tense-mood-aspect systems. Amsterdam and Philadelphia: John Benjamins, 1990. xvi + 240 pp.-Dale Tomich, Pedro San Miguel, El mundo que creó el azúcar: las haciendas en Vega Baja, 1800-873. Río Piedras, Puerto Rico: Ediciones Huracán, 1989. 224 pp.-César J. Ayala, Juan José Baldrich, Sembraron la no siembra: los cosecheros de tabaco puertorriqueños frente a las corporaciones tabacaleras, 1920-1934. Río Piedras, Puerto Rico: Ediciones Huracán, 1988.-Robert Forster, Jean-Michel Deveau, La traite rochelaise. Paris: Kathala, 1990. 334 pp.-Ernst van den Boogaart, Johannes Menne Postma, The Dutch in the Atlantic slave trade, 1600-1815. Cambridge: Cambridge University Press, 1990. xiv + 428 pp.-W.E. Renkema, T. van der Lee, Plantages op Curacao en hun eigenaren (1708-1845): namen en data voornamelijk ontleend aan transportakten. Leiden, the Netherlands: Grafaria, 1989. xii + 87 pp.-Mavis C. Campbell, Wim Hoogbergen, The Boni Maroon wars in Suriname. Leiden, the Netherlands: E.J. Brill, 1990. xvii + 254 pp.-Rafael Duharte Jiménez, Carlos Esteban Dieve, Los guerrilleros negros: esclavos fugitivos y cimarrones en Santo Domingo. Santo Domingo: Fundación Cultural Dominicana, 1989. 307 pp.-Rosemarijn Hoefte, Hans Ramsoedh, Suriname 1933-1944: koloniale politiek en beleid onder Gouverneur Kielstra. Delft, the Netherlands: Eburon, 1990. 255 pp.-Gert Oostindie, Kees Lagerberg, Onvoltooid verleden: de dekolonisatie van Suriname en de Nederlandse Antillen. Tilburg, the Netherlands: Instituut voor Ontwikkelingsvraagstukken, Katholieke Universiteit Brabant, 1989. ii + 265 pp.-Aisha Khan, Anthony de Verteuil, Eight East Indian immigrants. Port of Spain: Paria, 1989. xiv + 318 pp.-John Stiles, Willie L. Baber, The economizing strategy: an application and critique. New York: Peter Lang, 1988. xiii + 232 pp.-Faye V. Harrison, M.G. Smith, Poverty in Jamaica. Kingston: Institute of social and economic research, 1989. xxii + 167 pp.-Sidney W. Mintz, Dorian Powell ,Street foods of Kingston. Mona, Jamaica: Institute of social and economic research, 1990. xii + 125 pp., Erna Brodber, Eleanor Wint (eds)-Yona Jérome, Michel S. Laguerre, Urban poverty in the Caribbean: French Martinique as a social laboratory. New York: St. Martin's Press, 1990. xiv + 181 pp.

The world has already experienced several viral attacks in the 21st Century (Christou, 2011) have affected millions of people globally and caused substantial mortality and morbidity (Sutton, 2018). One that caused global pandemic and fear is newly emerged novel coronavirus (COVID-19) (Wilder-Smith et al., 2020). It is highly contagious, large enveloped, single-stranded, non-segmented, positive-sense RNA viruse that belong to coronaviridae family and genus Beta coronavirus (Yan et al., 2020). The viruses of coronaviridae family are further divided into two subfamilies; Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV) (Kindler et al., 2016). COVID-19 show close similarities to SARS-CoV due to phylogenetic relationship and genome structure. Word Health Organisation (WHO) has designated the current pandemic of SARS-CoV-2 infection as COVID-19 (Sohrabi et al., 2020). The virus shows high infectivity and mainly transmitted in the form of droplets with an incubation period of about 4-5 days. The onset of symptoms in patients is usually within 11-12 days (Linton et al., 2020). The most prominent symptoms seen in almost every patient includes dry cough, fever, fatigue, sore throat, lack of smell and taste, and severe patients suffer from breathing difficulties (Guan et al., 2019). We do not have any effective therapeutics or drugs approved by the U.S. Food and Drug Administration (FDA) to prevent or treat COVID-19 infections presently. The only treatment available for patients with COVID-19 is supportive care, including supplement oxygen and mechanical ventilator support. Therefore, there is an urgent need to develop an effective therapy to treat patients infected with COVID-19. The present situation calls much attention on prophylactics and therapeutics approach. This virus contain four structural proteins viz. the spike (S), membrane(M),envelop (E) and nucleocapsid (N).The S protein is considered to be highly immunogenic and contribute protective immunity in contrast to N, M and E proteins(Saha et al., 2020). Many laboratories have confirmed the entry of virus into human cells after its fusion with cell membrane of target tissues. After fusion, the S protein undergoes proteolysis by host proteases and give rise to S1 and S2 fragments. Thus, S1 protein is ready to interact with angiotensin converting 2 (ACE2) receptors present on respiratory and intestine epithelia besides alveolar macrophages present in the lungs(Cheng et al., 2020). Few studies have confirmed that ACE2 receptors are present in other cells too. S1 protein has a domain that interacts specifically with a domain on the ACE2 receptor. This interaction is must to produce the symptoms of disease (Nadeem et al., 2020).One must understand the role of chloroquine analogues works here by inhibiting virus fusion into the cell membrane. Some laboratories have generated both polyclonal and monoclonal antibodies against S1 domain and inhibited the interaction (Ravichandran et al., 2020; Zhao et al., 2020). This is one of the areas of immunotherapy. Some key amino acids present on the S1 domain initiate this interaction with high affinity (Saha et al., 2020). If these amino acids are blocked by monoclonal antibodies or lacked by chance due to mutation, the rate of infection would be reduced and patients may show minimal symptoms. This protective effect can be seen by reduced affinity of viruses to ACE2 receptor that would result in decreased infection. As the virus is getting mutated, some infected persons shown critical symptoms and other escape the disease severity. If the virus continues to mutate to lower its pathogenicity, there is a high possibility that it might coexist with humans. Using computational and bioinformatics, few laboratories have predicted B cells, T cells and cytotoxic T cells epitopes on S protein as well as other structural proteins (Baruah et al., 2020). This will help us to develop virus specific neutralizing antibodies by gene cloning or peptide synthesis-based approach. We personally feel if we have antisera from recovered patients of COVID-19 infection, using panel of peptides from different regions of viral proteins will help us to develop diagnosis kits and peptide-based vaccine. Since immune response is based on individual Human Leukocytes Antigens (HLA), the above approach will help to identify immunodominant regions on viral proteins. In addition, we can identify the polymorphic loci on HLA genes among infected persons showing clinical symptoms and others escape the disease severity to confirm the susceptibility towards infection, immunity and outcomes. COVID-19 infection has led to inflammatory storm due to presence of hyper activated immune cells and over-production of pro-inflammatory cytokines that may determine the outcome (Ye et al., 2020). Several studies have shown the presence of elevated levels of serum pro-inflammatory cytokines (IL-6, IL-1β and TNF-α) and increased immune inflammatory cells leading to cytokine storm, which could be partially responsible for immune mediated problems in the lungs of the patients(Ye et al., 2020; Felsenstein et al., 2020). Immune mediated, acute respiratory distress syndrome (ARDS) are commonly seen in ICU that are associated with poor outcome in patients with COVID-19 (Zhang et al., 2020).Therefore, specific blockade of inflammatory storm associated with hyper-inflammation during COVID-19 is an important therapeutic approach when compared to the systemic immunosuppression. To our knowledge, few clinical trials are ongoing to test the safety and efficacy of targeted therapies associated with IL-6, IL-1 receptor and Janus kinases (JAK) blockade in severe COVID-19 patients (Neurath, 2020; Russell et al., 2020). Like targeted therapies, several clinical trials of anti-viral drugs therapies such as Remdesivir, Lopinavin and Favipiravin are ongoing study (Şimşek and Ünal, 2020; Cao et al., 2020). The safety and efficacy of these trials are still unclear which need furthermore investigations in patients across the globe. Recently, few studies have confirmed blood clots in lungs and heart of patients with COVI-19 (Connors and Levy, 2020). We feel that treatment with blood thinner or low molecular weight heparin can reduce the problems of blood clots. Development of animal models of coronavirus infection are useful for testing vaccines and antiviral drugs. However, currently available animal models do not reproduce the inflammatory storm or pulmonary disease observed in individuals infected with SARS-CoV (Cleary et al., 2020). SARS-CoV viruses has been found to replicate in the lungs of domestic cats, hamsters, and mice. These animal models remain symptomatic (Tiwari et al., 2020). Therefore, we believe that development of animal models that establishes COVID-19 infections can show symptoms require a transgenic animal approach. The knowledge obtained from the study of animal models will help us in developing specific therapies, and vaccine would minimize pulmonary disease and optimise the inflammatory storm. Finally, we conclude that vaccine is the best for protection against COVID-19 infections, but development of antiviral drugs or targeted therapies are urgently required to cure COVID-19 patients.

In recent years, STEAM (Science, Technology, Engineering, Art, and Mathematics) has received wide attention. STEAM complements early childhood learning needs in honing 2nd century skills. This study aims to introduce a loose section in early childhood learning to pre-service teachers and then to explore their perceptions of how to use loose parts in supporting STEAM. The study design uses qualitative phenomenological methods. FGDs (Focus Group Discussions) are used as data collection instruments. The findings point to two main themes that emerged from the discussion: a loose section that supports freedom of creation and problem solving. Freedom clearly supports science, mathematics and arts education while problem solving significantly supports engineering and technology education. Keywords: Early Childhood Educators, Loose-part, STEAM References: Allen, A. (2016). Don’t Fear STEM: You Already Teach It! Exchange, (231), 56–59. Ansberry, B. K., & Morgan, E. (2019). Seven Myths of STEM. 56(6), 64–67. Bagiati, A., & Evangelou, D. (2015). Engineering curriculum in the preschool classroom: the teacher’s experience. European Early Childhood Education Research Journal, 23(1), 112–128. https://doi.org/10.1080/1350293X.2014.991099 Becker, K., & Park, K. (2011). Effects of integrative approaches among science , technology , engineering , and mathematics ( STEM ) subjects on students ’ learning : A preliminary meta-analysis. 12(5), 23–38. Berk, L. E. (2009). Child Development (8th ed.). Boston: Pearson Education. Can, B., Yildiz-Demirtas, V., & Altun, E. (2017). The Effect of Project-based Science Education Programme on Scientific Process Skills and Conception of Kindergargen Students. 16(3), 395–413. Casey, T., Robertson, J., Abel, J., Cairns, M., Caldwell, L., Campbell, K., … Robertson, T. (2016). Loose Parts Play. Edinburgh. Cheung, R. H. P. (2017). Teacher-directed versus child-centred : the challenge of promoting creativity in Chinese preschool classrooms. Pedagogy, Culture & Society, 1366(January), 1–14. https://doi.org/10.1080/14681366.2016.1217253 Clements, D. H., & Sarama, J. (2016). Math, Science, and Technology in the Early Grades. The Future of Children, 26(2), 75–94. Cloward Drown, K. (2014). Dramatic lay affordances of natural and manufactured outdoor settings for preschoolaged children. Dejarnette, N. K. (2018). Early Childhood Steam: Reflections From a Year of Steam Initiatives Implemented in a High-Needs Primary School. Education, 139(2), 96–112. DiGironimo, N. (2011). What is technology? Investigating student conceptions about the nature of technology. International Journal of Science Education, 33(10), 1337–1352. https://doi.org/10.1080/09500693.2010.495400 Dugger, W. E., & Naik, N. (2001). Clarifying Misconceptions between Technology Education and Educational Technology. The Technology Teacher, 61(1), 31–35. Eeuwijk, P. Van, & Zuzana, A. (2017). How to Conduct a Focus Group Discussion ( FGD ) Methodological Manual. Flannigan, C., & Dietze, B. (2018). Children, Outdoor Play, and Loose Parts. Journal of Childhood Studies, 42(4), 53–60. https://doi.org/10.18357/jcs.v42i4.18103 Fleer, M. (1998). The Preparation of Australian Teachers in Technology Education : Developing The Preparation of Australian Teachers in Technology Education : Developing Professionals Not Technicians. Asia-Pacific Journal of Teacher Education & Development, 1(2), 25–31. Freitas, H., Oliveira, M., Jenkins, M., & Popjoy, O. (1998). The focus group, a qualitative research method: Reviewing the theory, and providing guidelines to its planning. In ISRC, Merrick School of Business, University of Baltimore (MD, EUA)(Vol. 1). Gomes, J., & Fleer, M. (2019). The Development of a Scientific Motive : How Preschool Science and Home Play Reciprocally Contribute to Science Learning. Research in Science Education, 49(2), 613–634. https://doi.org/10.1007/s11165-017-9631-5 Goris, T., & Dyrenfurth, M. (n.d.). Students ’ Misconceptions in Science , Technology , and Engineering . Gull, C., Bogunovich, J., Goldstein, S. L., & Rosengarten, T. (2019). Definitions of Loose Parts in Early Childhood Outdoor Classrooms: A Scoping Review. The International Journal of Early Childhood Environmental Education, 6(3), 37. Hui, A. N. N., He, M. W. J., & Ye, S. S. (2015). Arts education and creativity enhancement in young children in Hong Kong. Educational Psychology, 35(3), 315–327. https://doi.org/10.1080/01443410.2013.875518 Jarvis, T., & Rennie, L. J. (1996). Perceptions about Technology Held by Primary Teachers in England. Research in Science & Technological Education, 14(1), 43–54. https://doi.org/10.1080/0263514960140104 Jeffers, O. (2004). How to Catch a Star. New York: Philomel Books. Kiewra, C., & Veselack, E. (2016). Playing with nature: Supporting preschoolers’ creativity in natural outdoor classrooms. International Journal of Early Childhood Environmental Education, 4(1), 70–95. Kuh, L., Ponte, I., & Chau, C. (2013). The impact of a natural playscape installation on young children’s play behaviors. Children, Youth and Environments, 23(2), 49–77. Lachapelle, C. P., Cunningham, C. M., & Oh, Y. (2019). What is technology? Development and evaluation of a simple instrument for measuring children’s conceptions of technology. International Journal of Science Education, 41(2), 188–209. https://doi.org/10.1080/09500693.2018.1545101 Liamputtong. (2010). Focus Group Methodology : Introduction and History. In Focus Group MethodoloGy (pp. 1–14). Liao, C. (2016). From Interdisciplinary to Transdisciplinary: An Arts-Integrated Approach to STEAM Education. 69(6), 44–49. https://doi.org/10.1080/00043125.2016.1224873 Lindeman, K. W., & Anderson, E. M. (2015). Using Blocks to Develop 21st Century Skills. Young Children, 70(1), 36–43. Maxwell, L., Mitchell, M., and Evans, G. (2008). Effects of play equipment and loose parts on preschool children’s outdoor play behavior: An observational study and design intervention. Children, Youth and Environments, 18(2), 36–63. McClure, E., Guernsey, L., Clements, D., Bales, S., Nichols, J., Kendall-Taylor, N., & Levine, M. (2017). How to Integrate STEM Into Early Childhood Education. Science and Children, 055(02), 8–11. https://doi.org/10.2505/4/sc17_055_02_8 McClure, M., Tarr, P., Thompson, C. M., & Eckhoff, A. (2017). Defining quality in visual art education for young children: Building on the position statement of the early childhood art educators. Arts Education Policy Review, 118(3), 154–163. https://doi.org/10.1080/10632913.2016.1245167 Mishra, L. (2016). Focus Group Discussion in Qualitative Research. TechnoLearn: An International Journal of Educational Technology, 6(1), 1. https://doi.org/10.5958/2249-5223.2016.00001.2 Monhardt, L., & Monhardt, R. (2006). Creating a context for the learning of science process skills through picture books. Early Childhood Education Journal, 34(1), 67–71. https://doi.org/10.1007/s10643-006-0108-9 Monsalvatge, L., Long, K., & DiBello, L. (2013). Turning our world of learning inside out! Dimensions of Early Childhood, 41(3), 23–30. Moomaw, S. (2012). STEM begins in the early years. School Science & Mathematics, 112(2), 57–58. Moomaw, S. (2016). Move Back the Clock, Educators: STEM Begins at Birth. School Science & Mathematics, 116(5), 237–238. Moomaw, S., & Davis, J. A. (2010). STEM Comes to Preschool. Young Cihildren, 12–18(September), 12–18. Munawar, M., Roshayanti, F., & Sugiyanti. (2019). Implementation of STEAM (Science, Technology, Engineering, Art, Mathematics)-Based Early Childhood Education Learning in Semarang City. Jurnal CERIA, 2(5), 276–285. National Research Council. (1996). National Science Education Standards. Washington, DC: National Academy of Sciences. Nicholson, S. (1972). The Theory of Loose Parts: An important principle for design methodology. Studies in Design Education Craft & Technology, 4(2), 5–12. O.Nyumba, T., Wilson, K., Derrick, C. J., & Mukherjee, N. (2018). The use of focus group discussion methodology: Insights from two decades of application in conservation. Methods in Ecology and Evolution, 9(1), 20–32. https://doi.org/10.1111/2041-210X.12860 Padilla-Diaz, M. (2015). Phenomenology in Educational Qualitative Research : Philosophy as Science or Philosophical Science ? International Journal of Educational Excellence, 1(2), 101–110. Padilla, M. J. (1990). The Science Process Skills. Research Matters - to the Science Teacher, 1(March), 1–3. Park, D. Y., Park, M. H., & Bates, A. B. (2018). Exploring Young Children’s Understanding About the Concept of Volume Through Engineering Design in a STEM Activity: A Case Study. International Journal of Science and Mathematics Education, 16(2), 275–294. https://doi.org/10.1007/s10763-016-9776-0 Rahardjo, M. M. (2019). Implementasi Pendekatan Saintifik Sebagai Pembentuk Keterampilan Proses Sains Anak Usia Dini. Scholaria: Jurnal Pendidikan Dan Kebudayaan, 9(2), 148–159. https://doi.org/10.24246/j.js.2019.v9.i2.p148-159 Robison, T. (2016). Male Elementary General Music Teachers : A Phenomenological Study. Journal of Music Teacher Education, 26(2), 77–89. https://doi.org/10.1177/1057083715622019 Rocha Fernandes, G. W., Rodrigues, A. M., & Ferreira, C. A. (2018). Conceptions of the Nature of Science and Technology: a Study with Children and Youths in a Non-Formal Science and Technology Education Setting. Research in Science Education, 48(5), 1071–1106. https://doi.org/10.1007/s11165-016-9599-6 Sawyer, R. K. (2006). Educating for innovation. 1(2006), 41–48. https://doi.org/10.1016/j.tsc.2005.08.001 Sharapan, H. (2012). ERIC - From STEM to STEAM: How Early Childhood Educators Can Apply Fred Rogers’ Approach, Young Children, 2012-Jan. Young Children, 67(1), 36–40. Siantayani, Y. (2018). STEAM: Science-Technology-Engineering-Art-Mathematics. Semarang: SINAU Teachers Development Center. Sikder, S., & Fleer, M. (2015). Small Science : Infants and Toddlers Experiencing Science in Everyday Family Life. Research in Science Education, 45(3), 445–464. https://doi.org/10.1007/s11165-014-9431-0 Smith-gilman, S. (2018). The Arts, Loose Parts and Conversations. Journal of the Canadian Association for Curriculum Studies, 16(1), 90–103. Sohn, B. K., Thomas, S. P., Greenberg, K. H., & Pollio, H. R. (2017). Hearing the Voices of Students and Teachers : A Phenomenological Approach to Educational Research. Qualitative Research in Education, 6(2), 121–148. https://doi.org/10.17583/qre.2017.2374 Strong-wilson, T., & Ellis, J. (2002). Children and Place : Reggio Emilia’s Environment as Third Teacher. Theory into Practice, 46(1), 40–47. Sutton, M. J. (2011). In the hand and mind: The intersection of loose parts and imagination in evocative settings for young children. Children, Youth and Environments, 21(2), 408–424. Tippett, C. D., & Milford, T. M. (2017). Findings from a Pre-kindergarten Classroom: Making the Case for STEM in Early Childhood Education. International Journal of Science and Mathematics Education, 15, 67–86. https://doi.org/10.1007/s10763-017-9812-8 Tippett, C., & Milford, T. (2017). STEM Resources and Materials for Engaging Learning Experiences. International Journal of Science & Mathematics Education, 15(March), 67–86. https://doi.org/10.1007/s10763-017-9812-8 Veselack, E., Miller, D., & Cain-Chang, L. (2015). Raindrops on noses and toes in the dirt: infants and toddlers in the outdoor classroom. Dimensions Educational Research Foundation. Yuksel-Arslan, P., Yildirim, S., & Robin, B. R. (2016). A phenomenological study : teachers ’ experiences of using digital storytelling in early childhood education. Educational Studies, 42(5), 427–445. https://doi.org/10.1080/03055698.2016.1195717

Guest Editors Kathryn Ricketts and Patrick Lewis, University of Regina, Education Johan Huizinga (1944) reminds us that, “Play is older than culture, for culture, however inadequately defined, always presupposes human society, and animals have not waited for man to teach them their playing” (1950, p. 1). In his work Homo Ludens [Man the player or Playing man] he argued that play is a fundamental human function that permeates all cultures from the beginning. Indeed, he argues that “human civilization has added no essential feature to the general idea of play” (p. 1). Play is not a by-product or consequence of culture—rather play exists before culture. More recently, Brian Boyd (2009) in his work, On the Origins of Stories argues that those things we so easily associate with culture and its development, like the arts and stories actually emerge from/through play. Play is often said to be universal--children everywhere are said to engage in some form of play. Nackmanovitch (1990) states, “Play is the free spirit of exploration, doing and being for it’s own pure joy” (p. 43). He goes on to call this state of play as the child-mind: “the most potent muse of all is our own inner child” (p. 44). However, even though play is said to be universal and widely recognizable, play is also very difficult to explicate. That is because play is not an object, an action or a place. Play is abstract, a dynamic and fluid process. Further complicating the idea of play are the plethora of meanings, so together the fluidity of play and the multiplicity of meanings make it impossible to adequately define play: almost any pursuit or act could be play simply by how we frame it (Johnson, Christie & Wardle, 2005, p. 11). The late Brian Sutton-Smith began his life long study of play with Huizinga’s work and at the end of the 20th century pondered “maybe the function of play is quite different from the kinds of things we have been looking at, or perhaps we have been looking at the wrong kinds of function” (Sutton-Smith, 1995, p. 282). Later he would ask, in The ambiguity of play (2001), if a theory of play was even possible. Carl Jung (1990) states that, “the creation of something new is not accomplished by the intellect but by the play instinct acting from inner necessity.” (as cited in Nachmanovitch, p. 42). He furthers this by stating “The inner mind plays with the objects it loves.” Part of this exploration of play is to investigate the interplay between the object, the story and the body. Sherry Turkle states, “We think with the objects we love; we love the objects we think with”(Turkle, 2007, p. 6). As we welcome perspectives from Performative Inquiry (Fels 1998), Performance Studies (Schechner,1977), and Thing Theorists (Turkle, 2007), we gain a broader perspective to the diverse approaches of play as a means for emancipatory processes in performance, therapy, education and philosophy. We are interested in methods that depart from text centricity and embrace transmediated (Siegel, 1995) understandings of self in relation to the world. This departure from the text, invites a playful imagining of stories to be constructed collectively, and calls attention to remembered histories while embracing current realities.Submissions This special issue of Childhood Studies imagines contributors taking up the provocation of the title (or a variation) to explore the ludic form across not only the early childhood landscape but through the myriad human activities that intersect and weave through that landscape and beyond. The Editors will consider works in and through: performing arts, performance studies, the visual arts, the child’s eyes, psychology, teacher education, educational research, teacher practice, play theory, and early learning and care. This list is by no means exhaustive, leaving open a playful approach to imagining play as otherwise. Please submit title and abstract by December 1st 2016. Reviews of abstracts will be completed by January1st, 2017 with authors notified of decisions shortly after that date. Authors of accepted abstracts will be invited to submit completed manuscripts by March 1st, 2017. Manuscripts should be a maximum of 6000 words. Please see the submission guidelines for specific details of preparing your manuscript. However, should your manuscript travel outside the usual format and content conventions we will endeavour to accommodate as best we can, given the parameters of JCS. If you have any questions about the special issue please contact Kathryn Ricketts (kathryn.ricketts@uregina.ca) and Patrick Lewis (patrick.lewis@uregina.ca) ReferencesBoyd, B. (2009). On the Origin of Stories: Evolution, Cognition and Fiction. Cambridge, MA: Harvard University Press.Fels, L. (1998). In the wind clothes dance on a line performative inquiry: A (re)search methodology (Unpublished doctoral dissertation). University of British Columbia, Vancouver, British Columbia, Canada.Huizinga, J. (1950). Homo ludens: A study of the play-element in culture. London: Roy Publishers.Jacobi, J. (Ed.). (1973). C. G. Jung: Psychological reflections: A new anthology of his writings, 1905-1961 (J. Jacobi & R. F. C. Hull, Trans.). Princeton, NJ: Princeton University Press.Schechner, R. (1977). Essays on performance theory 1970-1976. New York, NY: Drama Book Specialists.Siegel, M. (1995). More than words: The power of transmediation for learning. Canadian Journal of Education, Toronto, 20(4) 455 -475.Sutton-Smith, B. (2001). The ambiguity of play. Cambridge, MA: Harvard University Press.Nachmanovitch, S. (1990). Free play, improvisation in life and art. New York, NY: Penguin Putnam Inc.Turkle, S. (2007). Evocative objects: Things we think with. Cambridge, MA: Massachusetts Institute of Technology.

Introducción. El Informe del Defensor del Pueblo sobre violencia escolar –bullying- puso de manifiesto que en la mayoría de los centros educativos surgen situaciones de abuso y violencia entre los escolares (AA.VV., 2000). El contacto con profesionales de la enseñanza general nos revela que, con frecuencia, este fenómeno sólo llega a conocimiento de la comunidad educativa cuando, por desgracia, suele ser demasiado tarde, es decir, cuando las conductas de agresión y de victimización están muy arraigadas y su repercusión es dramática. Numerosos estudios sitúan el bullying como una manifestación de las malas relaciones interpersonales entre los alumnos (Ortega, 1994; Sutton y Smith, 1999). Ahondando en esta cuestión nos planteamos la influencia que puede tener la red de relaciones que se generan en el grupo aula y hasta que punto el víctima lo es no sólo de los ataques de su agresor sino del clima social que vive el grupo, que como un sistema cerrado lo excluye, mientras que el agresor cobra relevancia (Cerezo, Calvo y Sánchez, 2004). Objetivos. Desde las primeras investigaciones buscamos técnicas que permitieran la detección temprana del bullying, y que, a su vez, sirvieran de base para elaborar programas de intervención. Nos planteamos el diseño del test Bull como un instrumento que informara sobre la realidad social y afectiva del grupo aula y la implicación de sus miembros en el bullying, así como sobre características de tipo personal, de interacción social y escolar de los alumnos de cada grupo aula. El Bull-S. Test de evaluación de la agresividad entre escolares (Cerezo 2000), se presenta como una herramienta válida para la detección, medida y valoración de las situaciones de agresividad entre escolares. La prueba persigue tres objetivos fundamentales: Facilitar el análisis de las características socio-afectivas del grupo de iguales, ayudar al profesorado en la detección de situaciones de abuso entre escolares, y a través de sus resultados, avanzar en la elaboración de propuestas de intervención. Método. El instrumento, siguiendo la línea metodológica de la Sociometría y a través de la técnica de peer nomination, analiza de la estructura interna del aula definida bajo los criterios: aceptación-rechazo, agresividad–victimización y la apreciación de determinadas características personales que se pueden asociar a los alumnos directamente implicados.Resultados y conclusiones. El trabajo que aquí se presenta resume las características de este instrumento y su aplicabilidad e incluye una propuesta de intervención para un grupo de alumnos elaborada a partir del análisis del test Bull-S.

Today, more and more efforts are devoted to promoting an open network environment (Libicki 2000). This growing enthusiasm for interoperability is understandable, given the economics of networks. (Shapiro and Varian, 1998; Varian, Shapiro, and Farrell, 2005). To make the most of interconnection today, businesses must enhance their services by adding a variety of functions (Blumenthal and Clark 2000). For these purposes, they are seeking higher-level standards in support of middleware and software applications. While supporting the overall goal of interoperability, this paper sounds a cautionary note. It argues that the value of standards is contextual. Thus, while interoperability may be highly beneficial in a purely economic context, and with respect to the lower levels of the network, it might engender unintended consequences at higher levels where the network is intertwined with political and cultural realms. This paper contends that, as standards efforts become increasingly focused on the upper layers of the Internet, a broader set of evaluative criteria will be required to determine their true costs and benefits. Employing an interdisciplinary approach, this paper takes a first step in exploring these issues. Focusing on the highest–level applications in particular, it examines recent calls to create standards across virtual worlds, using the MPEG-V working group as a case study. Advocates for these standards foresee clear economic benefits for producers and maintainers of virtual worlds, as well as for their inhabitants (Sivan). We argue that such faith in the predictable outcomes of standards betrays a tendency both to think of virtual worlds as the intentional outcome of rational design, as well as to misapprehend the roles of diversity and play in discrete environments. We question this narrow economic perspective. Arguing that a metaverse—like all worlds—is highly complex, we contend that virtual world standards—ranging from EULAs to the software code itself—can only beget unpredictable outcomes, which will not only affect relationships between worlds, but inevitably within communities. Definitions and standards, whether integral to a world or positioned "between" worlds, nonetheless comprise its finite bounds and become part of what Steinkuehler calls "the mangle of play:" Inhabitants of synthetic worlds habitually "amplify, enhance, negate, accommodate, complement, and at times even ignore" even hard-coded rules (200). To identify the costs and benefits of standards in these complex environments, all of these relationships must be considered (Steinkuehler, 2004). As importantly, we argue that virtual diversity, like biological variety, is inherently beneficial to users of synthetic worlds. Inherently arbitrary, virtual worlds are de facto sites of playful activity: This is the source of corporate and individual interest in them as sites of innovation. To realize the benefits of what Sutton-Smith calls “the potentiation of adaptive variability,” we contend that what is needed is not standards across virtual worlds but rather a broad diversity of synthetic, discrete ecosystems. To make our case we briefly identify the economic rationale for network interoperability; next, characterize the metaverse as a complex environment, and describe the role that standards might play within it; and finally, we examine the case of the MPEG-V Working Group to determine the evaluative criteria being used to develop standards, employing a rhetorical analysis of the documents, both formal and informal, associated with this process.

An important objective of research is to create guiding evidences or propose improvements, solutions for practical activities. In order to apply proven research results, all institutions, organizations and individuals should consider appropriate research topics to better understand the issues and select information for the decision-making process and identify solutions for each specific situation. Although research is very important, there is a large gap that makes the widespread application of research evidence into practice difficult. On the basis of synthesizing and evaluating research documents as well as analyzing the real situations of the gap between the research results and the practical applications, the paper examines the origins and causes for the existence of the gap. Some suggestions to narrow down this gap are raised for Vietnam. References 1. Van de Ven, A. H., & Johnson, P. E., “Knowledge for theory and practice”, Academy of Management Review, 31 (2006) 4, 802-821.2. Khurana, R., “From higher aims to hired hands: The social transformation of American business schools and the unfulfilled promise of management as a profession”, Princeton and Oxford: Princeton University Press, 2007.3. Kieser, A., & Leiner, L., “Why the rigour-relevance gap in management research is unbridgeable”, Journal of Management Studies, 46 (2009) 3, 516-533.4. Rousseau, D. M., Manning, J., & Denyer, D., “Evidence in management and organizational science: Assembling the field’s full weight of scientific knowledge through syntheses”, Academy of Management Annals, 2 (2008) 1, 475-515. 5. Pfeffer, J., & Sutton, R. I., “Hard facts, dangerous half-truths and total nonsense: Profiting from evidence-based management”, Cambridge, MA: Harvard Business School, 2006. 6. Van de Ven, A. H., Engaged scholarship: A guide for organizational and social research, London: Oxford University Press, 2007.7. Bartunek, J. M., “Academic-practitioner collaboration need not require joint or relevant research: Toward a relational scholarship of integration”, Academy of Management Journal, 50 (2017) 6, 1323-1333.8. Briner, R. B., & Denyer, D., “Systematic review and evidence synthesis as a practice and scholarship tool”. In D. Rousseau (Ed.), Handbook of evidence-based management: Companies, classrooms, and research, Oxford University Press, 2010, from www.evidencebased-management.com/wp-content/ uploads/2010/01/chapter-8.doc 9. Briner, R. B., Denyer & Rousseau, D. M., “Evidence-based management: Concept cleanup time?”, Academy of Management Perspectives, 23 (2009) 4, 19-32.10. Smith, W. K., & Lewis, M. W., “Toward a theory of paradox: A dynamic equilibrium model of organizing”, Academy of Management Review, 36 (2011) 2, 381-403.11. Phạm Hồng Quất, “Khai thác, ứng dụng kết quả nghiên cứu trong các doanh nghiệp Việt nam: Nút thắt và những nguyên nhân”, Tạp chí Khoa học và Công nghệ Việt Nam, Số 9 (2013), 6-9.12. Mạnh Bôn, “Phần lớn ngân sách chi cho khoa học công nghệ để nuôi bộ máy, thực chi cho đề tài hiệu quả còn ít”, Báo Đầu tư online, 2018, truy cập tại: https://goo.gl/fFh7Pz.13. Đại học Quốc gia Hà Nội, Tọa đàm “Phát triển Khoa học công nghệ thông qua kết nối với doanh nghiệp”, 2018.14. Cục Sở hữu Trí tuệ, Báo cáo thường niên 2016.15. Phạm Xuân Khánh, “Nghiên cứu khoa học và sản xuất sản phẩm công nghệ có khả năng thương mại hóa trong các cơ sở giáo dục nghề nghiệp – Thực trạng và giải pháp”, 2018, truy cập tại: https://goo.gl/wN1NNZ 16. Minh Phong, “Mô hình sàn giao dịch công nghệ quốc gia trong cuộc cách mạng công nghiệp 4.0”, Báo Điện tử Tầm nhìn, 2018, truy cập tại: https://goo.gl/B6Ma8E 17. Vũ Trường Sơn, Lê Vũ Toàn, “Định giá công nghệ và vai trò của Nhà nước trên thị trường công nghệ”, Tin Chiến lược Chính sách, 2015, Bộ Khoa học và Công nghệ, truy cập tại: https://goo.gl/Hp4zvg18. Nguyễn Quang Tuấn, “Thúc đẩy thương mại hóa kết quả nghiên cứu và phát triển ở Việt Nam”, Tạp chí Cộng sản, 2010, truy cập tại: https://goo.gl/CGXef119. Nguyễn Đình Phúc, Nguyễn Trung Thành, Trịnh Minh Tâm, “Thực trạng và giải pháp thúc dẩy dịch vụ chuyển giao công nghệ ở Việt Nam hiện nay”, Tạp chí Khoa học và Công nghệ Việt Nam, Số 6 (2017), 10-12.20. Flodgren G, Parmelli E, Doumit G, Gattellari M, O’Brien MA, Grimshaw JA, “Local opinion leaders: effects on professional practice and health care outcomes”, Cochrane Database Syst Rev, 2011 Aug 10; (8):CD000125.21. ExpandNet, World Health Organization (WHO). “Beginning with the end in mind: planning pilot projects and other programmatic research for successful scaling up”, Geneva (Switzerland): WHO, 2011, view in this link: http://www.expandnet.net/tools.htm.

If love is a many-splendoured thing, then many of its splendours can be seen on toy shelves occupied by recent playthings such as Luv Buds, Love and Kisses, First Love, My Puppy Loves Me and Love-A-Lot Bear. As the meaning of childhood has changed, particularly over the last 150 years (Postman), toys have become a major means of demonstrating and defining love between generations, between genders and between humans and commodities. The widespread availability of commodities, all increasingly finetuned in their prescribed meanings under a regime of rampant advertising, has been a key factor in this development, which reached an apex in the final quarter of the last century. Major toy companies grew dramatically (Stern and Schoenhaus), details of toy-play became more intricately spelt out for children (Kline), and advertising leapt into bold new fronts, not the least being 30-minute toy advertisements masquerading as children’s television programs (Kunkel). Hand in hand with these developments came more sensual elaboration of characters and themes (Kline and Pentecost), in line with general moves towards “commodity aesthetics” (Haug). Selling not just toys but warm fuzzy feelings, toy companies took up slogans such as those surrounding Cabbage Patch Kids: “A special kind of love” and “Come open your arms to a Cabbage Patch Kid” (Blyskal; Jacob, Rodenhauser and Markert). Care Bears made similar claims, each in the set distinguished by heightened sensuality and segmenting the tasks previously performed by the simpler teddy bear. Thus, while semanticists and sociologists grapple with the meaning of the word “love” and the shifting nature of the concept, modern-day toy manufacturers have utilised a number of pertinent notions to underpin their marketing efforts. Such is the importance of marketing that even the basic design of toys can be a marketer’s initiative, giving rise to toys structured specifically around love themes. This is significant because mass marketed toys act as powerful media, transmitting messages, offering interpretations and interacting with other toys and commodities, particularly in terms of communicating the appeals and joys of consumerism on which their existence so heavily relies. Modern toys are not only surrounded by massive advertising and other related texts which leave little to the child’s imagination but, due to their “collaboration” with other commodities in cross-marketing ventures, are prominently positioned to advertise themselves and each other. Messages promoting mass marketed toys are interwoven into the presentation of each toy, its advertising package and other promotional media, including books, films, mall appearances and miniaturisation in children’s packaged fast-food meals. Such schemes highlight the sensuality and appeals of the toys and their themes. Of course children – and their parents – may create oppositional meanings from those intended. The messages are not closed and not always accepted wholesale or unquestioningly, but toys, like other media, often privilege particular readings favourable to the marketplace, as Ann du Cille has pointed out in relation to race and I have noted in relation to gender. Love fits snugly into the repertoire of appeals and joys, taking several different forms, determined mostly by each toy’s target audience and marketing profile. Four of the main variations on the love theme in toys are: Representational love Substitutional love Obligatory love Romantic love I will focus on closely linked representational and substitutional love. A toy that draws on straightforward representational love for its appeal to a parent or carer is typically marketed to suggest that toys are material proof of love, important links in a chain of bonding. At its most crass, the suggestion is that one can prove one’s love for a child by showering her or him with toys, though usually claims are more sophisticated, implying issues of quality and toy genre. In 1993 toy company Mattel was marketing its Disney toys as coming with the special offer of a book. An advertisement in the Australian women’s magazine New Idea spoke of the “magic” of Disney toys and how they would “enchant your child” but made even grander claims of the accompanying book: “It’s valued at $9.95…but you can’t put a price on the bond between you and your child when you read one of these Disney classic tales together.” The pressures of modern-day life are such that parents sometimes feel guilty that they cannot spend enough time with their children or do not know how to play with them or have little interest in doing so, in which case substitutional love can be a strong marketing claim to parents by toys. Among the major features of modern toys and their part in the relationship between parents and children, Brian Sutton-Smith pinpointed a contradiction (115, 127). Parents give their children toys to bond with them but also to simultaneously facilitate separation: “I give you this toy for you to play with…but now go away and play with it by yourself.” Toys not only serve the contradiction but also may offer reconciliation, pitching at a niche seeking substitutional love. Mattel was explicit about this with its promotion of the Heart Family, a set of dolls that on one hand stressed the importance of the traditional nuclear family while, on the other, offered carers a chance to opt out of the burdens of such rigid family organization (Langer). In a booklet entitled “Dear Mum and Dad, will you give me five minutes of your time?” distributed in Australia, Mattel claimed that major research had found that parents did not spend enough time with children and that children felt sad and angry about this. But there was a solution at hand: the purchase of the Heart Family, which incidentally came with an enormous range of accessories, each capable of chipping away at parental guilt though perhaps never quite assuaging it, for there always seemed to be one more accessory on the way. Most notable of these was the large, elegant, two-storeyed dollhouse, Loving Home. The dolls, their dollhouse, musical nursery, playground and umpteen other accessories were, it was insinuated by the Mattel booklet, a way of purchasing “values we all believe in. Sharing. Caring. Loving. Togetherness”. It seemed that the range of commodities could stand in for parents. More recently, Fisher-Price, now part of the Mattel group, has brought out a similar toy line, Loving Family, which hints even more strongly at links between family security and material possessions. Among Loving Family’s accessories are a multi-room family house with attached stable, a beach house, country home, townhouse, beauty salon and much more. While we cannot be sure that these suggested links and parental guilt in the absence of multiple toy gifts take root, toy companies, market analysts, toy advertising agencies and psychiatrists have noted trends that suggest they generally do. They have noted the impact on toy sales thought to be associated with “the high number of children with guilt-ridden working mothers, or from broken homes where parents are trying to buy their offspring’s affections” (McKee). Sometimes parents are keen to ensure the love and affection of playmates for their children. Toy companies also offer this type of substitutional love. Knickerbocker says of its wares: “Toys that love you back,” while among Galoob’s dolls is Mandi, My Favorite Friend. But what a gloomy picture of human companionship is painted by Phebe Bears’ slogan: “When there’s no one else to trust.” Space permits only the briefest comments on either obligatory love or romantic love; the key factor here is that both are strongly gendered. Boys need not concern themselves with either variety but girls’ toys abound which play a socialising role in respect to each. Toys contributing to a concept of love as obligation train girls for a motherhood role that ensures they will be emotionally as well as physically equipped. Kenner doll Baby Needs Me is only one of many such toys. The box of Baby Chris gift set claims the doll “needs your love and care” while Hush Little Baby “responds to your loving care” and “loves to be fed”. Matchbox’s Chubbles is claimed to “live on love”. If the weight of these obligations seems daunting to a girl, the Barbie doll genre offers her a carrot, suggesting that girls grow into women who are the recipients of love from men. A closer look reveals narcissism is surely the strongest type of love promoted by Barbie, but that is not explicit. Barbies such as Dream Date Barbie, Enchanted Evening Barbie and the numerous Barbie brides – even though Barbie is claimed to have never married – promote a straightforward and romanticised view of heterosexual relationships. In conclusion, each toy makes its own grab for attention, often promising love or one of its components, but usually working within a framework of short-term gratification, infatuation, obsession, the yearn to possess and elicitation of guilt – mostly unhealthy ingredients for relationships. While it may be hard to decide what love is, most would agree that, if it ideally has some sense of community responsibility and reciprocity about it, then the definitions offered by these toys fall short of the mark. Works Cited Blyskal, Jeff and Marie. “Media Doll – Born in a Cabbage Patch and Reared by a PR Man” The Quill, 73, November 1985: 32. du Cille, Ann. “Dyes and Dolls: Multicultural Barbie and the Merchandising of Difference” Differences 6(1) Spring 1994: 46-68. Haug, Wolfgang Fritz. Commodity Aesthetics: Ideology and Culture. New York: International General, 1987. Jacob, James E., Paul Rodenhauser and Ronald J. Markert. “The Benign Exploitation of Human Emotions: Adult Women and the Marketing of Cabbage Patch Kids” Journal of American Culture 10, Fall 1987: 61-71. Kline, Stephen, and Debra Pentecost, “The Characterization of Play: Marketing Children’s Toys” Play and Culture, 3(3), 1990: 235-255. Kline, Stephen, Out of the Garden: Toys, TV, and Children’s Culture in the Age of Marketing. London: Verso, 1993. Kunkel, Dale. “From a Raised Eyebrow to a Turned Back: The FCC and Children’s Product-Related Programming” Journal of Communication 38(4) Autumn 1988: 90-108. Langer, Beryl. “Commoditoys: Marketing Childhood” Arena no. 87, 1989: 29-37. McKee, Victoria. “All Stressed Out and Ready to Play” The Times (London), 19 December 1990: 17. Postman, Neil. The Disappearance of Childhood. New York: Dell, 1982. Stern, Sydney Ladensohn and Ted Schoenhaus. Toyland: The High-Stakes Game of the Toy Industry. Chicago: Contemporary Books, 1990. Sutton-Smith, Brian. Toys As Culture. New York: Garden Press, 1986. Varney, Wendy. “The Briar Around the Strawberry Patch: Toys, Women and Food” Women’s Studies International Forum no. 19, June 1996: 267-276. Varney, Wendy. “Of Men and Machines: Images of Masculinity in the Toybox” Feminist Studies 28(1) Spring 2002: 153-174. Citation reference for this article Substitute your date of access for Dn Month Year etc... MLA Style Varney, Wendy. "Love in Toytown" M/C: A Journal of Media and Culture 5.6 (2002). Dn Month Year < http://www.media-culture.org.au/0211/loveintotytown.php>. APA Style Varney, W., (2002, Nov 20). Love in Toytown. M/C: A Journal of Media and Culture, 5,(6). Retrieved Month Dn, Year, from http://www.media-culture.org.au/0211/loveintotytown.html