Academic literature on the topic 'Suspended Microchannel Resonator'
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Journal articles on the topic "Suspended Microchannel Resonator"
Vakilzadeh, Mohsen, Ramin Vatankhah, and Mohammad Eghtesad. "Tracking control of suspended microchannel resonators based on Krylov model order reduction method." Journal of Vibration and Control 25, no. 5 (November 7, 2018): 1019–30. http://dx.doi.org/10.1177/1077546318809609.
Full textMartín-Pérez, Alberto, Daniel Ramos, Javier Tamayo, and Montserrat Calleja. "Nanomechanical Molecular Mass Sensing Using Suspended Microchannel Resonators." Sensors 21, no. 10 (May 11, 2021): 3337. http://dx.doi.org/10.3390/s21103337.
Full textZakeri, Manizhe, and Seyed Mahmoud Seyedi Sahebari. "Modeling and simulation of a suspended microchannel resonator nano-sensor." Microsystem Technologies 24, no. 2 (July 25, 2017): 1153–66. http://dx.doi.org/10.1007/s00542-017-3478-6.
Full textYan, Han, Wen-Ming Zhang, Hui-Ming Jiang, and Kai-Ming Hu. "Pull-In Effect of Suspended Microchannel Resonator Sensor Subjected to Electrostatic Actuation." Sensors 17, no. 12 (January 8, 2017): 114. http://dx.doi.org/10.3390/s17010114.
Full textFolzer, Emilien, Tarik A. Khan, Roland Schmidt, Christof Finkler, Jörg Huwyler, Hanns-Christian Mahler, and Atanas V. Koulov. "Determination of the Density of Protein Particles Using a Suspended Microchannel Resonator." Journal of Pharmaceutical Sciences 104, no. 12 (December 2015): 4034–40. http://dx.doi.org/10.1002/jps.24635.
Full textMartín-Pérez, Ramos, Tamayo, and Calleja. "Coherent Optical Transduction of Suspended Microcapillary Resonators for Multi-Parameter Sensing Applications." Sensors 19, no. 23 (November 20, 2019): 5069. http://dx.doi.org/10.3390/s19235069.
Full textSon, Sungmin, Joon Ho Kang, Seungeun Oh, Marc W. Kirschner, T. J. Mitchison, and Scott Manalis. "Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis." Journal of Cell Biology 211, no. 4 (November 23, 2015): 757–63. http://dx.doi.org/10.1083/jcb.201505058.
Full textGodin, Michel, Andrea K. Bryan, Thomas P. Burg, Ken Babcock, and Scott R. Manalis. "Measuring the mass, density, and size of particles and cells using a suspended microchannel resonator." Applied Physics Letters 91, no. 12 (September 17, 2007): 123121. http://dx.doi.org/10.1063/1.2789694.
Full textKhan, M. F., S. Schmid, P. E. Larsen, Z. J. Davis, W. Yan, E. H. Stenby, and A. Boisen. "Online measurement of mass density and viscosity of pL fluid samples with suspended microchannel resonator." Sensors and Actuators B: Chemical 185 (August 2013): 456–61. http://dx.doi.org/10.1016/j.snb.2013.04.095.
Full textStockslager, Max A., Selim Olcum, Scott M. Knudsen, Robert J. Kimmerling, Nathan Cermak, Kristofor R. Payer, Vincent Agache, and Scott R. Manalis. "Rapid and high-precision sizing of single particles using parallel suspended microchannel resonator arrays and deconvolution." Review of Scientific Instruments 90, no. 8 (August 2019): 085004. http://dx.doi.org/10.1063/1.5100861.
Full textDissertations / Theses on the topic "Suspended Microchannel Resonator"
Levy-Tzedek, Shelly. "Biological detection by means of mass reduction in a suspended microchannel resonator." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28623.
Full textIncludes bibliographical references (p. 33-37).
Label-free detection is the detection of biomolecules and their interactions, without the use of a molecule external to the interaction, used as a reporter to indicate presence and/or location. The suspended microchannel resonator offers the opportunity to perform such label-free measurements. The goal of this work is to open new avenues of possible applications for the suspended channel. I introduce the concept of detecting mass subtraction as a new approach, rather than the conventional detection of mass addition. In a model implementation scenario of this approach, a mass-intensifying tag bound to a small ligand molecule will be equilibrated with surface-immobilized receptors, and later displaced by an identical, but label-free, ligand molecule. This approach offers opportunities to extend the sensitivity range of the device, as well as introduces new functionality for it. It enables researchers to follow, label-free, real-time enzymatic reactions, relative affinities of different ligands to a receptor, and presence of small molecules in a solution.
by Shelly Levy-Tzedek.
S.M.
Burg, Thomas P. (Thomas Peter). "Suspended microchannel resonators for biomolecular detection." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/34471.
Full textIncludes bibliographical references (leaves 115-124).
Microfabricated transducers enable the label-free detection of biological molecules in nanoliter sized samples. Integrating microfluidic detection and sample-preparation can greatly leverage experimental efforts in systems biology and pharmaceutical research by increasing analysis throughput while dramatically reducing reagent cost. Microfabricated resonant mass sensors are among the most sensitive devices for chemical detection, but degradation of the sensitivity in liquid has so far hindered their successful application in biology. This thesis introduces a type of resonant transducer that overcomes this limitation by a new device design: Adsorption of molecules to the inside walls of a suspended microfluidic channel is detected by measuring the change in mechanical resonance frequency of the channel. In contrast to resonant mass sensors submersed in water, the sensitivity and frequency resolution of the suspended microchannel resonator is not degraded by the presence of the fluid. Our device differs from a vibrating tube densitometer in that the channel is very thin, and only molecules that bind to the walls can build up enough mass to be detected; this provides a path to specificity via molecular recognition by immobilized receptors.
(cont.) Suspended silicon nitride channels have been fabricated through a sacrificial polysilicon process and bulk micromachining, and the packaging and microfluidic interfacing of the resonant sensors has been addressed. Device characterization at 30 mTorr ambient pressure reveals a quality factor of more than 10,000 for water filled resonators; this is two orders of magnitude higher than previously demonstrated Q-values of resonant mass sensors for biological measurements. Calculation of the noise and the sensitivity of suspended microchannel resonators indicate a physical limit for mass resolution of approximately 0.01 ng/cm2 (1 Hz bandwidth). A resolution of -0.1 ng/cm2 has been experimentally demonstrated in this work. This resolution constitutes a tenfold improvement over commercial quartz crystal microbalance based instruments. The ability to detect adsorbing biomolecules by resonance frequency has been validated through binding experiments with avidin and various biotinylated proteins.
by Thomas P. Burg.
Ph.D.
Son, Sungmin. "Suspended microchannel resonators for ultralow volume universal detection." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/44867.
Full textIncludes bibliographical references (leaves 32-33).
Universal detectors that maintain high sensitivity as the detection volume is reduced to the sub-nanoliter scale can enhance the utility of miniaturized total analysis systems ([mu]-TAS). Here the unique scaling properties of the suspended microchannel resonator (SMR) are exploited to show universal detection in a 10 pL analysis volume with a density detection limit of ~1 ([mu]g/cm³ (10 Hz bandwidth) and a linear dynamic range of six decades. Analytes with low UV extinction coefficients such as polyethylene glycol (PEG) 8 KDa, glucose, and glycine are measured with molar detection limits of 0.66 ([mu]M, 13.5 ([mu]M, and 31.6 ([mu]M, respectively. To demonstrate the potential for real-time monitoring, gel filtration chromatography was used to separate different molecular weights of PEG as the SMR acquired a chromatogram by measuring the eluate density. This work suggests that the SMR could offer a simple and sensitive universal detector for various separation systems from liquid chromatography to capillary electrophoresis. Moreover, since the SMR is itself a microfluidic channel, it can be directly integrated into ([mu]-TAS without compromising overall performance.
by Sungmin Son.
S.M.
Stockslager, Max A. "Measuring single-cell density using serial suspended microchannel resonators." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111934.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (pages 42-43).
Cells adjust their composition during important physiological processes, including cell cycle progression, apoptosis, and disease. Due to differences in the densities of water and the various macromolecules which compose cells, changes in cellular composition are reflected by changes in cell density. Previously, methods have been described for measuring density at the single-cell level using suspended microchannel resonators by weighing the same cell in fluids of different densities. Here we describe a high-throughput version of this approach, in which cells are weighed sequentially in three cantilevers containing fluids of different densities. The system design and operation are described, measurement uncertainty is characterized, and single-cell density measurements are compared to those obtained using existing techniques. As a demonstration, we use the system to characterize the biophysical response of CD8' T cells during activation. We find that single-cell density distinguishes between the phenotypically distinct human CD8' T cells of healthy vs. chronic lymphocytic leukemia donors, suggesting possible utility as a lymphocyte transformation assay. In summary, the system as described is capable of measuring single-cell density with improved throughput, and the approaches used here for on-chip fluid exchange are applicable to other SMR devices where it is desirable to weigh a cell in multiple fluids, e.g., to measure single-cell growth rate before and after drug or media perturbations..
by Max A. Stockslager.
S.M.
Von, Muhlen Marcio Goldani. "Label-free buoyant mass assays with suspended microchannel resonators." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62389.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (p. 105-112).
Improved methods are needed for routine, inexpensive monitoring of biomarkers that could facilitate earlier detection and characterization of complex diseases like cancer. Development of new assay formats based on microfluidic, label-free platforms enable radical reductions in assay complexity and reagent requirements with the potential for such applications. Suspended microchannel resonators (SMRs) are highly sensitive, batch-fabricated microcantilevers with embedded microchannels that can measure mass with femtogram precision. Biomolecules such as proteins and nucleic acids are denser than water, and their presence can thus be quantified by their buoyant mass, or increase in mass relative to the solution they displace. This thesis presents two approaches to conducting label-free, buoyant-mass immunoassays with SMRs with potential for clinical applications. The sensor surface can be functionalized to bind targets directly, or individually weighed polystyrene beads can be used as mobile supports. As in other label-free detection methods, biomolecular measurements in complex media such as serum are challenging due to high background signals from non-specific binding. We demonstrate that carboxybetaine-derived polymers developed to adsorb directly onto SMR SiO2 surfaces act as ultra-low fouling and functionalizable surface coatings. Coupled with a reference microcantilever, this approach enables detection of activated leukocyte cell adhesion molecule (ALCAM), a model cancer biomarker, in undiluted serum with a limit of detection of 10 ng/mL. Decoupling the complexity of surface modifications from the sensor precludes the need for specialized reagents. Monodisperse, micron-scale polystyrene beads are widely available and can be used as mobile supports, with the mean mass of a bead population quantifying target binding onto bead surfaces. Inherent mass variability in the bead population is masked by matching solution density to bead density. We demonstrate that by weighing hundreds of beads in 30 min, mean mass can be estimated with a resolution of 100 attograms. A proof-of-principle assay is demonstrated that quantifies IgG binding onto functionalized beads at 5.20 femtograms per bead.
by Marcio Goldani von Muhlen.
Ph.D.
Wang, Yu [Verfasser], Thomas [Akademischer Betreuer] Burg, and Christoph F. [Akademischer Betreuer] Schmidt. "Label-Free Measurements of Amyloid Formation by Suspended Microchannel Resonators / Yu Wang. Gutachter: Christoph F. Schmidt ; Thomas Burg. Betreuer: Thomas Burg." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://d-nb.info/1064148190/34.
Full textWang, Yu. "Label-Free Measurements of Amyloid Formation by Suspended Microchannel Resonators." Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0023-995D-E.
Full textConference papers on the topic "Suspended Microchannel Resonator"
Lee, Il, and Jungchul Lee. "Quality factor and vibration amplitude based viscosity measurements using suspended microchannel resonators." In 2012 IEEE Sensors. IEEE, 2012. http://dx.doi.org/10.1109/icsens.2012.6411424.
Full textLee, J., and S. P. Manalis. "SECOND EIGENMODE OPERATION OF SUSPENDED MICROCHANNEL RESONATORS FOR HIGH PRECISION FLOW-THROUGH MASS SENSING." In 2010 Solid-State, Actuators, and Microsystems Workshop. San Diego: Transducer Research Foundation, 2010. http://dx.doi.org/10.31438/trf.hh2010.7.
Full textLovera, Andrea, Roberta Calmo, Alessandro Chiadò, Davide Scaiola, Francesca Bosco, Carlo Ricciardi, Stefano Stassi, and Rosanna Toscano. "3D high-resolution laser printing of monolithic glass suspended microchannel resonators for enhanced biosensing." In Microfluidics, BioMEMS, and Medical Microsystems XIX, edited by Bonnie L. Gray and Holger Becker. SPIE, 2021. http://dx.doi.org/10.1117/12.2578756.
Full textLee, Il, and Jungchul Lee. "Measurement of mixing ratio and volume change of ethanol-water binary mixtures using suspended microchannel resonators." In 2012 IEEE Sensors. IEEE, 2012. http://dx.doi.org/10.1109/icsens.2012.6411272.
Full textTijani, M. E. H., Srinivas Vanapalli, and Simon Spoelstra. "Design of a Mechanical Resonator to Be Coupled to a Thermoacoustic Stirling-Engine." In ASME 2010 3rd Joint US-European Fluids Engineering Summer Meeting collocated with 8th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2010. http://dx.doi.org/10.1115/fedsm-icnmm2010-31151.
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