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1

M, Sanders Lynda, and Hendren R. Wayne, eds. Protein delivery: Physical systems. New York: Plenum Press, 1997.

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2

L, Audus Kenneth, and Raub Thomas J, eds. Biological barriers to protein delivery. New York: Plenum Press, 1993.

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3

1961-, McNally Eugene J., ed. Protein formulation and delivery. New York: M. Dekker, 2000.

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4

Peptide and protein delivery. London: Academic Press, 2011.

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5

P, Torchilin V., ed. Delivery of protein and peptide drugs in cancer. London: Imperial College, 2006.

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6

Alfred Benzon Symposium (43rd 1997 Royal Danish Academy of Sciences and Letters). Peptide and protein drug delivery: Proceedings of a symposium held at the Royal Danish Academy of Sciences and Letters, August 17-21, 1997 : Alfred Benzon Symposium 43. Edited by Christrup Lona, Frøkjær Sven 1947-, and Krogsgaard-Larsen Povl. Copenhagen: Munksgaard, 1998.

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7

Müller, Gerhard, and Bert Klebl. Protein kinases as drug targets. Weinheim: Wiley-VCH, 2011.

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8

NATO Advanced Research Workshop on Advanced Drug Delivery Systems for Peptides and Proteins (1986 Copenhagen, Denmark). Delivery systems for peptide drugs. New York: Plenum Press, 1986.

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9

Lee, Vincent H. L., 1951-, Hashida Mitsuru, and Mizushima Yutaka, eds. Trends and future perspectives in peptide and protein drug delivery. Chur, Switzerland: Harwood Academic, 1995.

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10

1958-, Cohen Smadar, and Bernstein Howard 1957-, eds. Microparticulate systems for the delivery of proteins and vaccines. New York: Marcel Dekker, 1996.

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11

Smadar, Cohen, and Bernstein Howard, eds. Microparticulate systems for the delivery of proteins and vaccines. New York: Marcel Dekker, 1996.

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12

Banga, Ajay K. Therapeutic peptides and proteins: Formulation, processing, and delivery systems. 2nd ed. Boca Raton, FL: CRC/Taylor & Francis, 2006.

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13

Banga, Ajay K. Therapeutic peptides and proteins: Formulation, processing, and delivery systems. Lancaster, Pa: Technomic Pub., 1995.

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14

L, Lundstrom Kenneth, and Chiu Mark L, eds. G protein-coupled receptors in drug discovery. Boca Raton: Taylor & Francis, 2005.

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15

G protein-coupled receptors in drug discovery. New York: Humana Press, 2009.

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16

1949-, Adjei Akete Lex, and Gupta Pramod K. 1959-, eds. Inhalation delivery of therapeutic peptides and proteins. New York: M. Dekker, 1997.

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17

G, De Boer A., ed. Drug absorption enhancement: Concepts, possibilities, limitations, and trends. Switzerland: Harwood Academic Publishers, 1994.

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18

Roland, Seifert, and Wieland Thomas, eds. G protein-coupled receptors as drug targets: Analysis of activation and constitutive activity. Weinheim: Wiley-VCH, 2005.

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19

Annette, Gilchrist, ed. GPCR molecular pharmacology and drug targeting: Shifting paradigms and new directions. Hoboken, N.J: Wiley, 2010.

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20

Kim, Sang Geon. AMPK-S6K1 signaling pathway as a target for treating hepatic insulin resistance. New York: Nova Science Publishers, 2010.

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21

Kim, Sang Geon. AMPK-S6K1 signaling pathway as a target for treating hepatic insulin resistance. Hauppauge, N.Y: Nova Science, 2009.

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22

Milligan, Graeme, and Sandra Siehler. G protein-coupled receptors: Structure, signaling, and physiology. Cambridge: Cambridge University Press, 2011.

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23

Dragging the lake: Poems. Pittsburgh: Carnegie Mellon University Press, 2006.

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24

Robert, Thomas. Dragging the lake: Poems. Pittsburgh: Carnegie Mellon University Press, 2006.

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25

Houghton, Peter J., and V. A. Polunovskiĭ. mTOR pathway and mTOR inhibitors in cancer therapy. New York: Humana Press, 2010.

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26

Williams, Sophie I., and Christopher E. Rogers. HER2 and cancer: Mechanism, testing, and targeted therapy. New York: Nova Biomedical Books, 2011.

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27

Hendren, R. Wayne, and Lynda M. Sanders. Protein Delivery: Physical Systems. Springer London, Limited, 2006.

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28

1961-, McNally Eugene J., and Hastedt Jayne E, eds. Protein formulation and delivery. 2nd ed. New York: Informa Healthcare, 2007.

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29

McNally, Eugene, Jayne E. Hastedt, and Eugene J. McNally. Protein Formulation and Delivery. Taylor & Francis Group, 2007.

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30

McNally, Eugene, and Jayne E. Hastedt. Protein Formulation and Delivery. Taylor & Francis Group, 1999.

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31

McNally, Eugene, Jayne E. Hastedt, and Eugene J. McNally. Protein Formulation and Delivery. Taylor & Francis Group, 2007.

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32

Sanders, Lynda M. Protein Delivery: Physical Systems. Springer, 2010.

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33

(Editor), Lynda M. Sanders, and R. Wayne Hendren (Editor), eds. Protein Delivery: Physical Systems (Pharmaceutical Biotechnology). Springer, 1997.

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34

Donev, Rossen. Protein and Peptide Nanoparticles for Drug Delivery. Elsevier Science & Technology, 2015.

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35

Donev, Rossen. Protein and Peptide Nanoparticles for Drug Delivery. Elsevier Science & Technology Books, 2015.

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36

Gill, Steven J., and Michael H. Nathanson. Central nervous system pathologies and anaesthesia. Edited by Philip M. Hopkins. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0081.

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Abstract:
Anaesthesia induces changes in many organ systems within the body, though clearly none more so than the central nervous system. The physiology of the normal central nervous system is complex and the addition of chronic pathology and polypharmacy creates a significant challenge for the anaesthetist. This chapter demonstrates a common approach for the anaesthetist and specific considerations for a wide range of neurological conditions. Detailed preoperative assessment is essential to gain understanding of the current symptomatology and neurological deficit, including at times restrictions on movement and position. Some conditions may pose challenges relating to communication, capacity, and consent. As part of the consent process, patients may worry that an anaesthetic may aggravate or worsen their neurological disease. There is little evidence to support this understandable concern; however, the risks and benefits must be considered on an individual patient basis. The conduct of anaesthesia may involve a preference for general or regional anaesthesia and requires careful consideration of the pharmacological and physiological impact on the patient and their disease. Interactions between regular medications and anaesthetic drugs are common. Chronically denervated muscle may induce hyperkalaemia after administration of succinylcholine. Other patients may have an altered response to non-depolarizing agents, such as those suffering from myasthenia gravis. The most common neurological condition encountered is epilepsy. This requires consideration of the patient’s antiepileptic drugs, often relating to hepatic enzyme induction or less commonly inhibition and competition for protein binding, and the effect of the anaesthetic technique and drugs on the patient’s seizure risk. Postoperative care may need to take place in a high dependency unit, especially in those with limited preoperative reserve or markers of frailty, and where the gastrointestinal tract has been compromised, alternative routes of drug delivery need to be considered. Overall, patients with chronic neurological conditions require careful assessment and preparation, a considered technique with attention to detail, and often higher levels of care during their immediate postoperative period.
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37

Torchilin, Vladimir P. Delivery of Protein and Peptide Drugs in Cancer. Imperial College Press, 2006.

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38

(Editor), Eugene J. McNally, and Jayne E. Hastedt (Editor), eds. Protein Formulation and Delivery, Second Edition (Drugs and the Pharmaceutical Sciences). 2nd ed. Informa Healthcare, 2007.

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39

Misra, Ambikanandan. Challenges in Delivery of Therapeutic Genomics and Proteomics. Elsevier, 2010.

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40

Bhatia, Saurabh. Nanotechnology in Drug Delivery. Taylor & Francis Group, 2021.

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41

Mannhold, Raimund, Hugo Kubinyi, Michael Hamacher, Bert Klebl, and Gerhard Müller. Protein Kinases As Drug Targets. Wiley & Sons, Incorporated, John, 2011.

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42

Folkers, Gerd, Raimund Mannhold, Hugo Kubinyi, Michael Hamacher, and Bert Klebl. Protein Kinases As Drug Targets. Wiley & Sons, Incorporated, John, 2011.

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43

Davis, S. S. Delivery Systems for Peptide Drugs. Springer, 2013.

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44

Tomlinson, E., Lisbeth Illum, and S. S. Davis. Delivery Systems for Peptide Drugs. Springer London, Limited, 2013.

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45

Uchegbu, L. F. Synthetic Surfactant Vesicles: Niosomes and Other Non-Phospholipid Vesicular Systems (Drug Targeting and Delivery). CRC, 2000.

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46

Bobone, Sara. Peptide and Protein Interaction with Membrane Systems: Applications to Antimicrobial Therapy and Protein Drug Delivery. Springer, 2016.

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47

Bobone, Sara. Peptide and Protein Interaction with Membrane Systems: Applications to Antimicrobial Therapy and Protein Drug Delivery. Springer London, Limited, 2014.

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48

Peptide and Protein Interaction with Membrane Systems: Applications to Antimicrobial Therapy and Protein Drug Delivery. Springer, 2014.

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49

Cohen, Smadar, and Howard Bernstein. Microparticulate Systems for the Delivery of Proteins and Vaccines. Taylor & Francis Group, 2020.

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50

Cohen, Smadar, and Howard Bernstein. Microparticulate Systems for the Delivery of Proteins and Vaccines. Taylor & Francis Group, 2020.

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