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Journal articles on the topic 'Sulfa drugs'

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Published: 10 December 2022
Last updated: 28 January 2023

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1

Jones, Susan. "How sulfa drugs work." Nature Biotechnology 30, no. 4 (April 2012): 333. http://dx.doi.org/10.1038/nbt.2188.

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2

al-Rashida, Mariya, Sajad Hussain, Mehwish Hamayoun, Aisha Altaf, and Jamshed Iqbal. "Sulfa Drugs as Inhibitors of Carbonic Anhydrase: New Targets for the Old Drugs." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/162928.

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Sulfa drugs are well-known antibacterial agents containing N-substituted sulfonamide group on para position of aniline ring (NH2RSO2NHR′). In this study 2,4-dichloro-1,3,5-triazine derivatives of sulfa drugs, sulfamerazine (1b), sulfaquinoxaline (2b), sulfadiazine (3b), sulfadimidine (4b), and sulfachloropyrazine (5b) (1a–5a) were synthesized and characterized. Their carbonic anhydrase inhibition activity was evaluated against bovine cytosolic carbonic anhydrase isozyme II (bCA II). For the sake of comparison the CA inhibition activity of the parent sulfa drugs (1b–5b) was also evaluated. A significant increase in CA inhibition activity of sulfa drugs was observed upon substitution with 2,4-dichloro-1,3,5-triazine moiety. Molecular docking studies were carried out to highlight binding site interactions. ADME properties were calculated to evaluate drug likeness of the compounds.
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3

Jayachandran, Seema, Adriana Lleras-Muney, and Kimberly V. Smith. "Modern Medicine and the Twentieth Century Decline in Mortality: Evidence on the Impact of Sulfa Drugs." American Economic Journal: Applied Economics 2, no. 2 (April 1, 2010): 118–46. http://dx.doi.org/10.1257/app.2.2.118.

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This paper studies the contribution of sulfa drugs, a groundbreaking medical innovation in the 1930s, to declines in US mortality. For several infectious diseases, sulfa drugs represented the first effective treatment. Using time-series and difference-in-differences methods, we find that sulfa drugs led to a 24 to 36 percent decline in maternal mortality, 17 to 32 percent decline in pneumonia mortality, and 52 to 65 percent decline in scarlet fever mortality between 1937 and 1943. Altogether, sulfa drugs reduced mortality by 2 to 3 percent and increased life expectancy by 0.4 to 0.7 years. We also find that sulfa drugs benefited whites more than blacks. (JEL I12, L65, N32, N72)
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4

Laub, George R. "Discovery of the Sulfa Drugs." Southern Medical Journal 79, no. 6 (June 1986): 782. http://dx.doi.org/10.1097/00007611-198606000-00040.

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5

Patel, Onisha G., Eddy K. Mberu, Alexis M. Nzila, and Ian G. Macreadie. "Sulfa drugs strike more than once." Trends in Parasitology 20, no. 1 (January 2004): 1–3. http://dx.doi.org/10.1016/j.pt.2003.10.009.

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6

Ellaithy, M. M., S. Z. El-Khateeb, and M. F. El-Tarras. "Colorimetric microdetermination of some sulfa drugs." Microchemical Journal 33, no. 2 (April 1986): 168–71. http://dx.doi.org/10.1016/0026-265x(86)90050-0.

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7

Caira, Mino R. "Sulfa Drugs as Model Cocrystal Formers." Molecular Pharmaceutics 4, no. 3 (May 4, 2007): 310–16. http://dx.doi.org/10.1021/mp070003j.

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8

Boreen, Anne L., William A. Arnold, and Kristopher McNeill. "Photochemical Fate of Sulfa Drugs in the Aquatic Environment: Sulfa Drugs Containing Five-Membered Heterocyclic Groups." Environmental Science & Technology 38, no. 14 (July 2004): 3933–40. http://dx.doi.org/10.1021/es0353053.

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9

Iliades, Peter, Steven R. Meshnick, and Ian G. Macreadie. "Mutations in the Pneumocystis jirovecii DHPS Gene Confer Cross-Resistance to Sulfa Drugs." Antimicrobial Agents and Chemotherapy 49, no. 2 (February 2005): 741–48. http://dx.doi.org/10.1128/aac.49.2.741-748.2005.

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ABSTRACT Pneumocystis jirovecii is a major opportunistic pathogen that causes Pneumocystis pneumonia (PCP) and results in a high degree of mortality in immunocompromised individuals. The drug of choice for PCP is typically sulfamethoxazole (SMX) or dapsone in conjunction with trimethoprim. Drug treatment failure and sulfa drug resistance have been implicated epidemiologically with point mutations in dihydropteroate synthase (DHPS) of P. jirovecii. P. jirovecii cannot be cultured in vitro; however, heterologous complementation of the P. jirovecii trifunctional folic acid synthesis (PjFAS) genes with an E. coli DHPS-disrupted strain was recently achieved. This enabled the evaluation of SMX resistance conferred by DHPS mutations. In this study, we sought to determine whether DHPS mutations conferred sulfa drug cross-resistance to 15 commonly available sulfa drugs. It was established that the presence of amino acid substitutions (T517A or P519S) in the DHPS domain of PjFAS led to cross-resistance against most sulfa drugs evaluated. The presence of both mutations led to increased sulfa drug resistance, suggesting cooperativity and the incremental evolution of sulfa drug resistance. Two sulfa drugs (sulfachloropyridazine [SCP] and sulfamethoxypyridazine [SMP]) that had a higher inhibitory potential than SMX were identified. In addition, SCP, SMP, and sulfadiazine (SDZ) were found to be capable of inhibiting the clinically observed drug-resistant mutants. We propose that SCP, SMP, and SDZ should be considered for clinical evaluation against PCP or for future development of novel sulfa drug compounds.
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10

Haller, J. S. "The First Miracle Drugs: How the Sulfa Drugs Transformed Medicine." Journal of the History of Medicine and Allied Sciences 63, no. 1 (August 5, 2007): 119–21. http://dx.doi.org/10.1093/jhmas/jrm035.

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11

Hammoudeh, Dalia I., Ying Zhao, Stephen W. White, and Richard E. Lee. "Replacing sulfa drugs with novel DHPS inhibitors." Future Medicinal Chemistry 5, no. 11 (July 2013): 1331–40. http://dx.doi.org/10.4155/fmc.13.97.

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12

Toler, Steven M., and Ignacio Rodriguez. "Not All Sulfa Drugs Are Created Equal." Annals of Pharmacotherapy 38, no. 12 (October 26, 2004): 2166–67. http://dx.doi.org/10.1345/aph.1e206.

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13

Bettinetti, Giampiero, and Ferdinando Giordano. "Interaction Between Trimethoprim and Some Sulfa Drugs." Drug Development and Industrial Pharmacy 14, no. 4 (January 1988): 431–49. http://dx.doi.org/10.3109/03639048809151875.

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14

Parks, Owen W. "Photodegradation of Sulfa Drugs by Fluorescent Light." Journal of AOAC INTERNATIONAL 68, no. 6 (November 1, 1985): 1232–34. http://dx.doi.org/10.1093/jaoac/68.6.1232.

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Abstract Thin layer chromatographic and liquid chromatographic procedures were used to show that sulfonamides containing a heterocyclic amine moiety and free N1 acidic hydrogen will photodegrade under fluorescent light in model systems containing riboflavin. The photodegradation product was characteristic of the drug. In-depth studies on sulfamethazine showed that the drug also photodegraded in the presence of lumichrome and flavin mononucleotide; the rate of photodegradation depended on the photosensitizer and its concentration. Crude polar liver extracts sensitized the photodegradation of sulfamethazine, but to a degree less than expected on the basis of reported riboflavin content of livers. It is recommended that procedures for quantitating sulfa drugs and their metabolites be performed in subdued lighting and/or that amber or low actinic vessels be used to prevent losses due to photochemical reactions.
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15

Greenberger, P. A. "Allergy to sulfa drugs with postcoital urticaria." JAMA: The Journal of the American Medical Association 265, no. 11 (March 20, 1991): 1458b—1458. http://dx.doi.org/10.1001/jama.265.11.1458b.

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16

Dadfar, Etratsadat, Fatemeh Shafiei, and Tahereh M. Isfahani. "Structural Relationship Study of Octanol-Water Partition Coefficient of Some Sulfa Drugs Using GA-MLR and GA-ANN Methods." Current Computer-Aided Drug Design 16, no. 3 (June 2, 2020): 207–21. http://dx.doi.org/10.2174/1573409915666190301124714.

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Aim and Objective: Sulfonamides (sulfa drugs) are compounds with a wide range of biological activities and they are the basis of several groups of drugs. Quantitative Structure-Property Relationship (QSPR) models are derived to predict the logarithm of water/ 1-octanol partition coefficients (logP) of sulfa drugs. Materials and Methods: A data set of 43 sulfa drugs was randomly divided into 3 groups: training, test and validation sets consisting of 70%, 15% and 15% of data point, respectively. A large number of molecular descriptors were calculated with Dragon software. The Genetic Algorithm - Multiple Linear Regressions (GA-MLR) and genetic algorithm -artificial neural network (GAANN) were employed to design the QSPR models. The possible molecular geometries of sulfa drugs were optimized at B3LYP/6-31G* level with Gaussian 98 software. The molecular descriptors derived from the Dragon software were used to build a predictive model for prediction logP of mentioned compounds. The Genetic Algorithm (GA) method was applied to select the most relevant molecular descriptors. Results: The R2 and MSE values of the MLR model were calculated to be 0.312 and 5.074 respectively. R2 coefficients were 0.9869, 0.9944 and 0.9601for the training, test and validation sets of the ANN model, respectively. Conclusion: Comparison of the results revealed that the application the GA-ANN method gave better results than GA-MLR method.
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17

Johnson, Theresa, Ikhlas A. Khan, Mitchell A. Avery, Juliana Grant, and Steven R. Meshnick. "Quantitative Structure-Activity Relationship Studies of a Series of Sulfa Drugs as Inhibitors of Pneumocystis carinii Dihydropteroate Synthetase." Antimicrobial Agents and Chemotherapy 42, no. 6 (June 1, 1998): 1454–58. http://dx.doi.org/10.1128/aac.42.6.1454.

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ABSTRACT Sulfone and sulfanilamide sulfa drugs have been shown to inhibit dihydropteroate synthetase (DHPS) isolated from Pneumocystis carinii. In order to develop a pharmacophoric model for this inhibition, quantitative structure-activity relationships (QSAR) for sulfa drugs active against DHPS have been studied. Accurate 50% inhibitory concentrations were collected for 44 analogs, and other parameters, such as partition coefficients and molar refractivity, were calculated. Conventional multiple regression analysis of these data did not provide acceptable QSAR. However, three-dimensional QSAR provided by comparative molecular field analysis did give excellent results. Upon removal of poorly correlated analogs, a data set of 36 analogs, all having a common NHSO2 group, provided a cross-validatedr 2 value of 0.699 and conventionalr 2 value of 0.964. The resulting pharmacophore model should be useful for understanding and predicting the binding of DHPS by new sulfa drugs.
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18

Martucci, A., I. Braschi, L. Marchese, and S. Quartieri. "Recent advances in clean-up strategies of waters polluted with sulfonamide antibiotics: a review of sorbents and related properties." Mineralogical Magazine 78, no. 5 (October 2014): 1115–40. http://dx.doi.org/10.1180/minmag.2014.078.5.03.

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AbstractSeveral strategies are available to reduce or eliminate recalcitrant sulfonamide antibiotics (sulfa drugs) from aqueous media. These contaminants are bioactive and ubiquitous pollutants of soils and watercourses and are known to induce bacterial resistance. Here the biological, chemical and physical methods developed over the last 5 years to decontaminate waters polluted with sulfa drugs are reviewed with special attention to procedures that make use of porous adsorbent materials and their applicability to real waters.
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19

Wainwright, Milton. "The First Miracle Drugs: How the Sulfa Drugs Transformed Medicine (review)." Perspectives in Biology and Medicine 50, no. 4 (2007): 639–42. http://dx.doi.org/10.1353/pbm.2007.0057.

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20

Mohammed, Salim, Azzam AL-Hadedi, and Salih Abood. "The Role of Sulfa Drugs in our Life." Rafidain Journal of Science 31, no. 3 (September 1, 2022): 64–74. http://dx.doi.org/10.33899/rjs.2022.175395.

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21

Blinc, Robert, Janez Seliger, Aleksander Zidans˘ek, Veselko Žagar, Fani Milia, and Hector Robert. "14N nuclear quadrupole resonance of some sulfa drugs." Solid State Nuclear Magnetic Resonance 30, no. 2 (September 2006): 61–68. http://dx.doi.org/10.1016/j.ssnmr.2006.02.003.

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22

Kornfeld, Olga, and Brian P. Nichols. "Vitamin B3confers resistance to sulfa drugs inSaccharomyces cerevisiae." FEMS Microbiology Letters 251, no. 1 (October 2005): 137–41. http://dx.doi.org/10.1016/j.femsle.2005.07.037.

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23

Castelli, Laura A., Nga P. Nguyen, and Ian G. Macreadie. "Sulfa drug screening in yeast: fifteen sulfa drugs compete with p-aminobenzoate in Saccharomyces cerevisiae." FEMS Microbiology Letters 199, no. 2 (May 2001): 181–84. http://dx.doi.org/10.1111/j.1574-6968.2001.tb10671.x.

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24

Haruki, H., M. G. Pedersen, K. I. Gorska, F. Pojer, and K. Johnsson. "Tetrahydrobiopterin Biosynthesis as an Off-Target of Sulfa Drugs." Science 340, no. 6135 (May 23, 2013): 987–91. http://dx.doi.org/10.1126/science.1232972.

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25

Kumar, Vineet, Ram Thaimattam, Sanjay Dutta, Parthapratim Munshi, and Arunachalam Ramanan. "Structural landscape of multicomponent solids based on sulfa drugs." CrystEngComm 19, no. 21 (2017): 2914–24. http://dx.doi.org/10.1039/c7ce00217c.

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26

Merali, S., Y. Zhang, D. Sloan, and S. Meshnick. "Inhibition of Pneumocystis carinii dihydropteroate synthetase by sulfa drugs." Antimicrobial Agents and Chemotherapy 34, no. 6 (June 1, 1990): 1075–78. http://dx.doi.org/10.1128/aac.34.6.1075.

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27

Guzzo, Marissa B., Hoa T. Nguyen, Thanh H. Pham, Monika Wyszczelska-Rokiel, Hieronim Jakubowski, Kerstin A. Wolff, Sam Ogwang, et al. "Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs." PLOS Pathogens 12, no. 10 (October 19, 2016): e1005949. http://dx.doi.org/10.1371/journal.ppat.1005949.

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28

ASAHI, Yutaka, Masami TANAKA, and Mayumi SUGIMOTO. "Titration of sulfa drugs with perchloric acid in nonaqueoussolution." Bunseki kagaku 40, no. 12 (1991): 889–93. http://dx.doi.org/10.2116/bunsekikagaku.40.12_889.

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29

Jean-Paul Gaudillière. "The First Miracle Drugs: How the Sulfa Drugs Transformed Medicine (review)." Bulletin of the History of Medicine 83, no. 1 (2009): 218–20. http://dx.doi.org/10.1353/bhm.0.0197.

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30

Rajendiran, N., and J. Thulasidhasan. "Binding of Sulfamerazine and Sulfamethazine to Bovine Serum Albumin and Nitrogen Purine Base Adenine: A Comparative Study." International Letters of Chemistry, Physics and Astronomy 59 (September 2015): 170–87. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.59.170.

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Quenching of bovine serum albumin (BSA) and DNA base (adenine) by sulfamerazine (SM) and sulfamethazine (SMT) was studied using UV-visible, fluorescence cyclic voltammetry and molecular docking methods. A strong fluorescence quenching reaction of SM and SMT to BSA/adenine was observed and the quenching mechanism was suggested as static. Both drugs can bind to BSA and adenine with stoichiometric ratio of 1:1 and the protein - drug complexes are stabilized mainly by hydrogen bonds and van der Waals interaction. Compared to SM, SMT contributes substantially higher binding efficiency with BSA/adenine. With addition of drug solution to the adenine/BSA, the oxidation and the reduction peaks shifted towards high and low potentials, respectively. Ro, J, r and E values in the BSA-drugs are higher than that of adenine – drug molecules suggest that binding of the sulfa drugs with BSA is higher than adenine –drug molecules. Docking method specify that bioactive site of sulfa drugs moiety, the aniline group is interacted with the BSA molecules.
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31

Rajendiran, N., and J. Thulasidhasan. "Binding of Sulfamerazine and Sulfamethazine to Bovine Serum Albumin and Nitrogen Purine Base Adenine: A Comparative Study." International Letters of Chemistry, Physics and Astronomy 59 (September 14, 2015): 170–87. http://dx.doi.org/10.56431/p-067rwb.

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Quenching of bovine serum albumin (BSA) and DNA base (adenine) by sulfamerazine (SM) and sulfamethazine (SMT) was studied using UV-visible, fluorescence cyclic voltammetry and molecular docking methods. A strong fluorescence quenching reaction of SM and SMT to BSA/adenine was observed and the quenching mechanism was suggested as static. Both drugs can bind to BSA and adenine with stoichiometric ratio of 1:1 and the protein - drug complexes are stabilized mainly by hydrogen bonds and van der Waals interaction. Compared to SM, SMT contributes substantially higher binding efficiency with BSA/adenine. With addition of drug solution to the adenine/BSA, the oxidation and the reduction peaks shifted towards high and low potentials, respectively. Ro, J, r and E values in the BSA-drugs are higher than that of adenine – drug molecules suggest that binding of the sulfa drugs with BSA is higher than adenine –drug molecules. Docking method specify that bioactive site of sulfa drugs moiety, the aniline group is interacted with the BSA molecules.
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32

Aziz Alibeg, Ammar Abdul. "Synthesis of Mutual Pro-drugs through coupling of Etodolac And Tolmetin by Sulfa drugs." American Journal of PharmTech Research 8, no. 1 (February 8, 2018): 336–42. http://dx.doi.org/10.46624/ajptr.2018.v8.i1.024.

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33

Rehman, Aziz-Ur, Muhammad Athar Abbasi, Sabahat Zahra Siddiqui, Shahid Rasool, Sadia Jabeen, Amar Masood Joyia, and Asma Salah-Ud-Din Gondal. "Synthesis, spectral evaluation and pharmacological screening of some sulfa drugs." Open Journal of Chemistry 2, no. 1 (June 30, 2019): 1–10. http://dx.doi.org/10.30538/psrp-ojc2019.0007.

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34

Navarro, Abel E., Haebin Lim, Elliot Chang, Yeon Lee, and Angela S. Manrique. "Uptake of Sulfa Drugs from Aqueous Solutions by Marine Algae." Separation Science and Technology 49, no. 14 (September 4, 2014): 2175–81. http://dx.doi.org/10.1080/01496395.2014.926930.

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35

Triglia, Tony, and Alan F. Cowman. "The mechanism of resistance to sulfa drugs in Plasmodium falciparum." Drug Resistance Updates 2, no. 1 (February 1999): 15–19. http://dx.doi.org/10.1054/drup.1998.0060.

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36

Hong, Y. L., P. A. Hossler, D. H. Calhoun, and S. R. Meshnick. "Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs." Antimicrobial Agents and Chemotherapy 39, no. 8 (August 1, 1995): 1756–63. http://dx.doi.org/10.1128/aac.39.8.1756.

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37

Temcharoen, Punya, Suwanna Nerapattanakid, Chaivat Toskulkao, Thirayudh Glinsukon, Chitkawee Paovaro, and Somsak Ruchirawat. "Mutagenic activity of newly synthesized sulfa drugs to Salmonella typhimurium." Mutation Research/Genetic Toxicology 321, no. 4 (June 1994): 187–95. http://dx.doi.org/10.1016/0165-1218(94)90069-8.

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38

Connolly, C., and J. Golden. ""Remarkable Improvement": Sulfa Drugs and Pediatric Meningococcal Meningitis, 1937-1949." PEDIATRICS 127, no. 6 (May 2, 2011): 1011–13. http://dx.doi.org/10.1542/peds.2010-2744.

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39

Mustafa, Seham, Abdulhakeem Alsughayer, Abdelhamid Elgazzar, Abdelzaher Elassar, and Fakhria Al Sagheer. "Effect of sulfa drugs on kidney function and renal scintigraphy." Nephrology 19, no. 4 (March 24, 2014): 210–16. http://dx.doi.org/10.1111/nep.12200.

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40

Agrawal, Y. K., R. Giridhar, and S. K. Menon. "Sulfa Drugs: Thermodynamic Proton—Ligand and Metal—Ligand Stability Constants." Journal of Pharmaceutical Sciences 76, no. 12 (December 1987): 903–6. http://dx.doi.org/10.1002/jps.2600761212.

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41

Boison, Joe O., and Lily J.-Y. Keng. "Determination of Sulfadimethoxine and Sulfamethazine Residues in Animal Tissues by Liquid Chromatography and Thermospray Mass Spectrometry." Journal of AOAC INTERNATIONAL 78, no. 3 (May 1, 1995): 651–58. http://dx.doi.org/10.1093/jaoac/78.3.651.

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Abstract A simple, sensitive, and rapid method for simultaneous determination of sulfamethazine and sulfadimethoxine residues in animal tissues by liquid chromatography (LC) with on-line confirmation by thermospray mass spectrometry is reported. Tissue extracts, after cleanup on C18 cartridges, were injected into a reversed-phase C18 column, and the sulfa drugs were determined by ultraviolet (UV) detection at 265 nm. On-line confirmation of sulfamethazine and sulfadimethoxine in the extracts by mass spectrometry was obtained by feeding the sulfa drugs eluting from the chromatographic column after UV detection directly into the ion source of a mass spectrometer with a thermospray ionization LC interface. Analytical results obtained with the LC method, which has detection limits of 2 and 10 ng/g of tissue, for sulfamethazine and sulfadimethoxine, respectively, compared favorably with those obtained with the official thin-layer chromatographic–densitometric method.
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42

Parks, Owen W. "Screening Tests for Sulfa Drugs and/or Dinitrobenzamide Coccidiostats and Their Monoamino Metabolites in Chicken Livers." Journal of AOAC INTERNATIONAL 68, no. 1 (January 1, 1985): 20–23. http://dx.doi.org/10.1093/jaoac/68.1.20.

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Abstract Two procedures were developed for the simultaneous determination of 0.1 ppm sulfaquinoxaline and sulfadimethoxine, 1.0 ppm Zoalene and nitromide, and/or 0.1 ppm of their reduced coccidiostat metabolities from the same sample of chicken liver. Both methods include blender extraction of 5 g liver with chloroform-ethyl acetate (1 + 1), adsorption of the drugs and metabolites on neutral alumina, and subsequent elution with 0.2M carbonate buffer (pH 11.0). In Method A, all parent drugs and coccidiostat metabolites were partitioned into dichloromethane, following the addition of a small amount of tetrabutylammonium hydroxide (TBAH). The presence of the dinitrobenzamides was confirmed by the formation of a color with TBAH, which occurs when the solvent is concentrated (Zoalene = green; nitromide = red). Sulfa drugs and coccidiostat metabolites were detected by the Bratton- Marshall reaction after thin layer chromatographic (TLC) separation. Method B separates the individual classes by selective extraction techniques. The coccidiostats and their metabolites were extracted from the buffer eluate by ethyl acetate-dichloromethane (3 + 1) before ion pairing: sulfa drugs were extracted with dichloromethane after ion pairing with TBAH. The detection techniques were similar to those described for Method A.
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43

Afeltra, Javier, Jacques F. G. M. Meis, Roxana G. Vitale, Johan W. Mouton, and Paul E. Verweij. "In Vitro Activities of Pentamidine, Pyrimethamine, Trimethoprim, and Sulfonamides against Aspergillus Species." Antimicrobial Agents and Chemotherapy 46, no. 6 (June 2002): 2029–31. http://dx.doi.org/10.1128/aac.46.6.2029-2031.2002.

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ABSTRACT The susceptibilities of 70 strains of Aspergillus species were tested against seven different sulfa drugs and pentamidine by a microdilution method with RPMI 1640 and yeast nitrogen base media. Sulfamethoxazole, sulfadiazine, and pentamidine were active in vitro. The MICs obtained with RPMI 1640 were significantly higher than those with yeast nitrogen base. More studies are needed to further elucidate the action of these drugs.
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44

Salgado Guerrero, Maria, Oscar Mena Miranda, Ana B. Arevalo, Nevena Barjaktarovic, and Barbara Mendez. "Bullous Lupus: An Atypical Case of Refractory Disease in a Patient with Sulfa Allergy." Case Reports in Rheumatology 2020 (July 27, 2020): 1–5. http://dx.doi.org/10.1155/2020/8873337.

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Bullous systemic lupus erythematosus (BSLE) is a rare cutaneous autoimmune disorder characterized by rapid, widespread vesiculobullous lesions in patients with Systemic Lupus Erythematosus (SLE). BSLE can present as the initial manifestation of SLE and may be a marker of severe disease. In this case report, we present a case of a 22-year-old African American woman with BSLE and impaired renal function with subsequent nephrotic range proteinuria concerning for lupus nephritis and autoimmune hemolytic anemia, refractory to systemic corticosteroids, immunoglobulin, and mycophenolate mofetil, requiring dapsone after careful desensitization due to prior history of angioedema with sulfa drugs. This case highlights the importance of the prompt recognition of BSLE as the initial manifestations of SLE and illustrates the association of BSLE with severe disease and the benefit of concomitant use of dapsone with corticosteroids and other immunosuppressant drugs, even in patients with a history of sulfa allergy.
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45

de la Horra, Carmen, Vicente Friaza, Rubén Morilla, Juan Delgado, Francisco J. Medrano, Robert F. Miller, Yaxsier de Armas, and Enrique J. Calderón. "Update on Dihydropteroate Synthase (DHPS) Mutations in Pneumocystis jirovecii." Journal of Fungi 7, no. 10 (October 13, 2021): 856. http://dx.doi.org/10.3390/jof7100856.

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A Pneumocystis jirovecii is one of the most important microorganisms that cause pneumonia in immunosupressed individuals. The guideline for treatment and prophylaxis of Pneumocystis pneumonia (PcP) is the use of a combination of sulfa drug-containing trimethroprim and sulfamethoxazole. In the absence of a reliable method to culture Pneumocystis, molecular techniques have been developed to detect mutations in the dihydropteroate synthase gene, the target of sulfa drugs, where mutations are related to sulfa resistance in other microorganisms. The presence of dihydropteroate synthase (DHPS) mutations has been described at codon 55 and 57 and found almost around the world. In the current work, we analyzed the most common methods to identify these mutations, their geographical distribution around the world, and their clinical implications. In addition, we describe new emerging DHPS mutations. Other aspects, such as the possibility of transmitting Pneumocystis mutated organisms between susceptible patients is also described, as well as a brief summary of approaches to study these mutations in a heterologous expression system.
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46

Brown, Ashli, Mercedes Fernandez, Shaquan Parker, ZeAndra D. Whitfield, Xiaomei Zheng, and Ghislain R. Mandouma. "Synthesis and Antibacterial Property of An Encapsulated Sulfonamide Nanoparticle in a Multidisciplinary Approach." International Journal for Innovation Education and Research 9, no. 9 (September 1, 2021): 151–57. http://dx.doi.org/10.31686/ijier.vol9.iss9.3322.

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Multigram quantity of a novel Sulfa Drug complex -poly(amido)amine-sulfonamide or PAMAM-Sulfa- was synthesized, from commercially available materials. It was characterized with spectroscopic methods such as nuclear magnetic resonance (NMR). The Kirby-Bauer test was used to test it against gram positive and/or gram negative bacteria using different concentrations of an ethanol solution of the PAMAM-Sulfa complex. The goal of this experiment was to synthesize and study the effect of water soluble encapsulated sulfonamides on common bacteria by undergraduate students engaging in research involving more than one STEM discipline. Students synthesized a dendrimer-sulfonamide complex before evaluating its antibiotic properties. In doing so, students employed research methods that are common to chemistry, biology and nanoscience while also learning about mechanism of infectious diseases, drugs and drug resistance. This project allowed students to combine aspects of scientific research that are usually done separately, and an opportunity to observe the seamlessness of multidisciplinary science.
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47

Issa, Y. M., A. L. El-Ansary, and W. Selim. "Enthalpimetric Determination of Sulfa Drugs in Pure Form and Pharmaceutical Formulations." Analytical Letters 31, no. 1 (January 1998): 131–46. http://dx.doi.org/10.1080/00032719808001838.

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48

Sutherland, W. S., J. J. Laserna, M. J. Angebranndt, and J. D. Winefordner. "Surface-enhanced Raman analysis of sulfa drugs on colloidal silver dispersion." Analytical Chemistry 62, no. 7 (April 1990): 689–93. http://dx.doi.org/10.1021/ac00206a008.

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49

Iskander, Madlene L., H. A. A. Medien, and S. Nashed. "Kinetics and determination of sulfa drugs via interaction with p-benzoquinone." Microchemical Journal 39, no. 1 (February 1989): 43–49. http://dx.doi.org/10.1016/0026-265x(89)90007-6.

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50

KOKUE, Eiichi, Minoru SHIMODA, Kazuko SAKURADA, and Junko WADA. "Pharmacokinetics of oral sulfa drugs and gastric emptying in the pig." Journal of Pharmacobio-Dynamics 11, no. 8 (1988): 549–54. http://dx.doi.org/10.1248/bpb1978.11.549.

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