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1

Enrico, Marani, ed. The subthalamic nucleus: Development, cytology, topography and connections. Berlin: Springer, 2008.

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2

Marani, Enrico, Tjitske Heida, Egbert A. J. F. Lakke, and Kamen G. Usunoff. The Subthalamic Nucleus Part I: Development, Cytology, Topography and Connections. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-79460-8.

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Heida, Tjitske, Enrico Marani, and Kamen G. Usunoff. The Subthalamic Nucleus Part II: Modelling and Simulation of Activity. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-79462-2.

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MacMillan, Meeka. Responses of human thalamic and subthalamic nucleus neurons during sequential movements. Ottawa: National Library of Canada, 2002.

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5

Romas, John. Quantifying decreases in parkinsonian rigidity with surgical intervention in the subthalamic nucleus. Ottawa: National Library of Canada, 2001.

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6

Enrico Marani,Kamen G. Usunoff,Tjitske Heida. The Subthalamic Nucleus. Springer, 2008.

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7

The Subthalamic Nucleus. Springer, 2008.

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8

The Subthalamic Nucleus. Springer, 2008.

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9

Enrico Marani,Tjitske Heida,Egbert A. J. F. Lakke. The Subthalamic Nucleus. Springer, 2008.

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10

Cunic, Danny. Functional assessment of the subthalamic nucleus. 2005.

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11

Montgomery, Erwin B. Approach to DBS in the Vicinity of the Subthalamic Nucleus. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190259600.003.0011.

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The regional anatomy around the DBS lead in the subthalamic nucleus (STN) determines efficacy and adverse effects. Understanding the regional anatomy allows the programmer to adjust the stimulation to provide optimal benefit and the absence of adverse effects.The STN lies near the junction of the diencephalon and mesencephalon. It is just ventral to the thalamus, just lateral to the brachium conjunctivum and red nucleus, and medial and dorsal to the internal capsule. These structures are important because inappropriate stimulation causes side effects. For examples: Electrical fields spreading to ascending sensory medial lemniscus and spinothalamic pathways behind the STN produce paresthesias. Inadvertent stimulation of the brachium conjunctivum can cause ataxia and loss of balance. The red nucleus lies in the brachium conjunctivum, and the exiting axons from the oculomotor nucleus run within the red nucleus. Electrical fields spreading to these structures can result in disconjugate gaze and diplopia. Stimulating the internal capsule laterally or dorsally can cause tonic muscle contractions.
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12

Fawcett, Adrian Paul. The role of human subthalamic nucleus in saccade control. 2006.

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13

Usunoff, Kamen G., Enrico Marani, and Tjitske Heida. Subthalamic Nucleus : Part II: Modelling and Simulation of Activity. Springer London, Limited, 2008.

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14

Levy, Ron. Neuronal activity in the subthalamic nucleus and globus pallidus of patients with Parkinson's disease. 2001.

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15

Mason, Peggy. Basal Ganglia. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190237493.003.0025.

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The core function of the basal ganglia is action selection, the process of choosing between mutually exclusive actions. Under baseline or default conditions, the basal ganglia suppress movement and prevent more than one movement from occurring simultaneously. The importance of chunking and operational learning is explored through exemplary typing tasks. Pathways through the basal ganglia employ the same input and output ports. Inputs far outnumber outputs from the basal ganglia. Subcortical loops through the basal ganglia are more effective than are cortical loops. The functions of the hyperdirect, direct and indirect pathways to motor control in the skeletomotor loop are detailed. Hemiballismus, Parkinson’s disease, and Huntington’s disease are key basal ganglia disorders. The use of deep brain stimulation (DBS) of the subthalamic nucleus as a treatment for Parkinson’s disease is discussed. Finally, additional basal ganglia loops such as the oculomotor loop are introduced.
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